RAB11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.84705095
2synaptic vesicle docking involved in exocytosis (GO:0016081)4.66329613
3regulation of synaptic vesicle exocytosis (GO:2000300)4.23367975
4vocalization behavior (GO:0071625)4.11774767
5synaptic vesicle maturation (GO:0016188)3.96917086
6postsynaptic membrane organization (GO:0001941)3.90151326
7regulation of synapse structural plasticity (GO:0051823)3.80831696
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80047202
9regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.78711332
10regulation of synaptic vesicle transport (GO:1902803)3.75943273
11positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.75295662
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66574871
13neurotransmitter-gated ion channel clustering (GO:0072578)3.63624440
14glutamate secretion (GO:0014047)3.63098320
15neuron cell-cell adhesion (GO:0007158)3.59407015
16negative regulation of erythrocyte differentiation (GO:0045647)3.52143985
17regulation of glutamate receptor signaling pathway (GO:1900449)3.47578180
18cerebral cortex radially oriented cell migration (GO:0021799)3.46595696
19protein localization to synapse (GO:0035418)3.43649897
20negative regulation of microtubule polymerization (GO:0031115)3.31864695
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26037530
22barbed-end actin filament capping (GO:0051016)3.25333623
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24930438
24cell-cell junction maintenance (GO:0045217)3.20619244
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19388808
26establishment of mitochondrion localization (GO:0051654)3.18982745
27sodium ion export (GO:0071436)3.18698624
28positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11746755
29cullin deneddylation (GO:0010388)3.09008913
30G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08884225
31negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03871205
32neurotransmitter secretion (GO:0007269)3.03500870
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.00099526
34regulation of relaxation of muscle (GO:1901077)2.95313445
35urinary tract smooth muscle contraction (GO:0014848)2.94424961
36negative regulation of dendrite morphogenesis (GO:0050774)2.93142828
37neuronal action potential propagation (GO:0019227)2.91736457
38cellular potassium ion homeostasis (GO:0030007)2.90029982
39presynaptic membrane assembly (GO:0097105)2.89750244
40response to pheromone (GO:0019236)2.89692790
41neuronal ion channel clustering (GO:0045161)2.87939440
42establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85589225
43mitochondrion transport along microtubule (GO:0047497)2.85589225
44NADH metabolic process (GO:0006734)2.83744416
45negative regulation of dendrite development (GO:2000171)2.83245236
46ATP hydrolysis coupled proton transport (GO:0015991)2.82641782
47energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82641782
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81790620
49regulation of defense response to virus by virus (GO:0050690)2.80608457
50long-term synaptic potentiation (GO:0060291)2.77405652
51dopamine receptor signaling pathway (GO:0007212)2.76300586
52presynaptic membrane organization (GO:0097090)2.75385604
53protein retention in ER lumen (GO:0006621)2.73706058
54regulation of synaptic transmission, GABAergic (GO:0032228)2.71001024
55viral protein processing (GO:0019082)2.69527313
56regulation of ARF protein signal transduction (GO:0032012)2.68584447
57stress fiber assembly (GO:0043149)2.67756648
58cell junction maintenance (GO:0034331)2.66009689
59protein targeting to plasma membrane (GO:0072661)2.65999932
60protein deneddylation (GO:0000338)2.65967124
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65931668
62mechanosensory behavior (GO:0007638)2.64902176
63positive regulation of synapse assembly (GO:0051965)2.64730970
64positive regulation of membrane potential (GO:0045838)2.64629778
65regulation of respiratory system process (GO:0044065)2.64578981
66regulation of early endosome to late endosome transport (GO:2000641)2.63952635
67adenosine receptor signaling pathway (GO:0001973)2.62627512
68regulation of voltage-gated calcium channel activity (GO:1901385)2.62166108
69cell communication by electrical coupling (GO:0010644)2.61060116
70positive regulation of synapse maturation (GO:0090129)2.60645678
71regulation of neurotransmitter secretion (GO:0046928)2.59814746
72protein localization to endosome (GO:0036010)2.59660592
73tricarboxylic acid cycle (GO:0006099)2.58416652
74locomotory exploration behavior (GO:0035641)2.58357442
75positive regulation of neurotransmitter transport (GO:0051590)2.58153373
76regulation of synapse maturation (GO:0090128)2.57404319
77neuron recognition (GO:0008038)2.56996953
78oxygen transport (GO:0015671)2.56374820
79layer formation in cerebral cortex (GO:0021819)2.55111939
80activation of MAPKKK activity (GO:0000185)2.54128807
81neuron-neuron synaptic transmission (GO:0007270)2.53918943
82* transferrin transport (GO:0033572)2.53649131
83synaptic transmission, glutamatergic (GO:0035249)2.53545859
84positive regulation of amino acid transport (GO:0051957)2.52678604
85peptidyl-tyrosine autophosphorylation (GO:0038083)2.51157528
86synaptic vesicle endocytosis (GO:0048488)2.50855465
87regulation of ARF GTPase activity (GO:0032312)2.50256339
88modulation by virus of host process (GO:0019054)2.50117485
89synaptic vesicle transport (GO:0048489)2.48772792
90establishment of synaptic vesicle localization (GO:0097480)2.48772792
91chaperone-mediated protein transport (GO:0072321)2.48419753
92regulation of neurotransmitter transport (GO:0051588)2.47542810
93regulation of cell communication by electrical coupling (GO:0010649)2.46837041
94adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.46834219
95cellular response to monoamine stimulus (GO:0071868)2.46068459
96cellular response to catecholamine stimulus (GO:0071870)2.46068459
97axonal fasciculation (GO:0007413)2.45274720
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.44628322
99response to dietary excess (GO:0002021)2.44513294
100exploration behavior (GO:0035640)2.44468151
101regulation of neuronal synaptic plasticity (GO:0048168)2.44031076
102activation of protein kinase A activity (GO:0034199)2.44001981
103negative regulation of cation channel activity (GO:2001258)2.43042039
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43002392
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.42885230
106cell migration in hindbrain (GO:0021535)2.42275068
107signal complex assembly (GO:0007172)2.41844631
108regulation of extracellular matrix disassembly (GO:0010715)2.40448156
109regulation of glycogen (starch) synthase activity (GO:2000465)2.40277059
110cerebellar granule cell differentiation (GO:0021707)2.40066425
111auditory behavior (GO:0031223)2.37279964
112maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36581256
113positive regulation of synaptic transmission (GO:0050806)2.35903734
114hippocampus development (GO:0021766)2.35655335
115response to auditory stimulus (GO:0010996)2.35634584
116dendritic spine organization (GO:0097061)2.35501843
117protein complex biogenesis (GO:0070271)2.34336252
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.34288127
119semaphorin-plexin signaling pathway (GO:0071526)2.32786318
120positive regulation of protein dephosphorylation (GO:0035307)2.32420158
121regulation of protein targeting to membrane (GO:0090313)2.31450695
122striatum development (GO:0021756)2.31423102
123modulation by symbiont of host cellular process (GO:0044068)2.31319317
124negative regulation of cell size (GO:0045792)2.30452013
125regulation of synaptic transmission, glutamatergic (GO:0051966)2.29251991
126regulation of synapse assembly (GO:0051963)2.28843008
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.28825776
128positive regulation of amine transport (GO:0051954)2.27879309
129actin filament polymerization (GO:0030041)2.27639084
130* ferric iron transport (GO:0015682)2.27428431
131* trivalent inorganic cation transport (GO:0072512)2.27428431
132substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.26174144
133substrate-independent telencephalic tangential migration (GO:0021826)2.26174144
134regulation of action potential (GO:0098900)2.26102324
135regulation of membrane repolarization (GO:0060306)2.25938432
136positive regulation of action potential (GO:0045760)2.25602403
137regulation of synaptic transmission, dopaminergic (GO:0032225)2.25544559
138intracellular estrogen receptor signaling pathway (GO:0030520)2.25444001
139phagosome maturation (GO:0090382)2.25411899
140detection of calcium ion (GO:0005513)2.24927493
141positive regulation of neurotransmitter secretion (GO:0001956)2.24731626
142regulation of vesicle fusion (GO:0031338)2.24691843
143dendritic spine morphogenesis (GO:0060997)2.24576423
144neuromuscular process controlling balance (GO:0050885)2.24107658
145protein insertion into membrane (GO:0051205)2.23355595
146ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.22745392
147regulation of autophagic vacuole assembly (GO:2000785)2.22067858
148negative regulation of catenin import into nucleus (GO:0035414)2.21051799
149positive regulation of receptor recycling (GO:0001921)2.19188959
150detection of temperature stimulus involved in sensory perception (GO:0050961)2.18627963
151detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.18627963
152response to parathyroid hormone (GO:0071107)2.16909779
153modulation by virus of host morphology or physiology (GO:0019048)2.16756138
154regulation of hydrogen peroxide metabolic process (GO:0010310)2.15826047
155cerebellar Purkinje cell layer development (GO:0021680)2.15632275
156regulation of synaptic plasticity (GO:0048167)2.15111937
157positive regulation of histone deacetylation (GO:0031065)2.14013192
158regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.13923502
159neuron projection regeneration (GO:0031102)2.13813018
160positive regulation of pseudopodium assembly (GO:0031274)2.13469526
161retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.13197709
162negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.12846235
163positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.10912983
164negative regulation of cell killing (GO:0031342)2.10415833
165negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.10415833
166positive regulation of axon extension (GO:0045773)2.09820243
167positive regulation of Rap GTPase activity (GO:0032854)2.09488133
168respiratory system process (GO:0003016)2.07995831
169regulation of amyloid precursor protein catabolic process (GO:1902991)2.06745967
170negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.05577509
171regulation of protein dephosphorylation (GO:0035304)2.05376744
172potassium ion homeostasis (GO:0055075)2.05188080
173response to monoamine (GO:0071867)2.04014709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58851795
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.32327840
3GBX2_23144817_ChIP-Seq_PC3_Human3.21569397
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16728468
5* LXR_22292898_ChIP-Seq_THP-1_Human3.02036251
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97279920
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95893228
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79320390
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79147574
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.77815558
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.67065640
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66916838
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62900120
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62900120
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61852280
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56524206
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.56476943
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.39844429
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39840184
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32569770
21VDR_21846776_ChIP-Seq_THP-1_Human2.30732729
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.27801172
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27602949
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26534388
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.22584547
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.21707365
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.21508556
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19672387
29REST_21632747_ChIP-Seq_MESCs_Mouse2.16989514
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15762411
31KDM2B_26808549_Chip-Seq_DND41_Human2.14445341
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.08532522
33KDM2B_26808549_Chip-Seq_K562_Human2.06861681
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01884460
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96726606
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96157676
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.95800412
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91506084
39DROSHA_22980978_ChIP-Seq_HELA_Human1.88440264
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84834442
41P68_20966046_ChIP-Seq_HELA_Human1.83848665
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81668775
43RACK7_27058665_Chip-Seq_MCF-7_Human1.79646119
44TCF7_22412390_ChIP-Seq_EML_Mouse1.75538001
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.75181677
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.70070401
47CTCF_27219007_Chip-Seq_Bcells_Human1.64298613
48MYC_22102868_ChIP-Seq_BL_Human1.63229001
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60633352
50SMC4_20622854_ChIP-Seq_HELA_Human1.60292914
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58506678
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.57519364
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57202058
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55447713
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54672487
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50740582
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47978095
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.47455868
59BCL6_27268052_Chip-Seq_Bcells_Human1.45041257
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44014129
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.43539611
62CREB1_26743006_Chip-Seq_LNCaP_Human1.43050044
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41298537
64TAF15_26573619_Chip-Seq_HEK293_Human1.40652317
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.38617388
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38536688
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36357656
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33807229
69BCOR_27268052_Chip-Seq_Bcells_Human1.32767600
70VDR_24763502_ChIP-Seq_THP-1_Human1.30887583
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29566862
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28886022
73* GATA1_19941827_ChIP-Seq_MEL_Mouse1.28042912
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27585695
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26965473
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26608192
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26562089
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25595323
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24181911
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23697308
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23596338
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22612802
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.21575613
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20829394
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20674847
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19797349
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19761861
88SA1_27219007_Chip-Seq_Bcells_Human1.19583966
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17972457
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.17497555
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17148079
92RNF2_27304074_Chip-Seq_NSC_Mouse1.16685494
93UTX_26944678_Chip-Seq_JUKART_Human1.12616360
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11970255
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11776220
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10595129
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10427491
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10423275
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10307452
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09116506
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08718963
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.08693996
103P300_19829295_ChIP-Seq_ESCs_Human1.08061543
104TP63_22573176_ChIP-Seq_HFKS_Human1.07959589
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07936588
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.07845310
107OCT4_19829295_ChIP-Seq_ESCs_Human1.07604499
108MAF_26560356_Chip-Seq_TH2_Human1.07420132
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06683157
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06651505
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06633657
112CTCF_20526341_ChIP-Seq_ESCs_Human1.06306207
113AR_21572438_ChIP-Seq_LNCaP_Human1.06239856
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05954679
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04887656
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04114096
117PHF8_20622854_ChIP-Seq_HELA_Human1.04081562
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03980367
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03812845
120MAF_26560356_Chip-Seq_TH1_Human1.01914653
121* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01321009
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99054862
123* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98338600
124SMAD4_21799915_ChIP-Seq_A2780_Human0.97941412
125SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97617161
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.93166529
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92210587
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92058328
129AR_25329375_ChIP-Seq_VCAP_Human0.91860459
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.90785327
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90529911
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89850922
133* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89606872
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88620906
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88607627
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85189056
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85157501
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85146943
139* PRDM14_20953172_ChIP-Seq_ESCs_Human0.84898790
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.84213672
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83723475
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83435798
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.81976728
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80474421
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80413526
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80262042
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80072634
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.79294003
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78701229
150EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78477966
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.77356561
152IGF1R_20145208_ChIP-Seq_DFB_Human0.77283129
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.77105664
154CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76509242
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75951814
156TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75690395
157SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74836681
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73984718
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73577801
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.73249121
161YY1_21170310_ChIP-Seq_MESCs_Mouse0.72930299
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72899105
163CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72452691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.68869666
2MP0004859_abnormal_synaptic_plasticity3.65264806
3MP0003329_amyloid_beta_deposits3.22356740
4MP0003122_maternal_imprinting3.21279675
5MP0003635_abnormal_synaptic_transmissio2.76414960
6MP0009278_abnormal_bone_marrow2.69818864
7MP0001968_abnormal_touch/_nociception2.65510313
8MP0005058_abnormal_lysosome_morphology2.55768255
9MP0003303_peritoneal_inflammation2.52637272
10MP0000751_myopathy2.35363826
11MP0009745_abnormal_behavioral_response2.31242218
12MP0002736_abnormal_nociception_after2.30995771
13MP0002064_seizures2.28604108
14MP0002063_abnormal_learning/memory/cond2.27276303
15MP0001984_abnormal_olfaction2.25684997
16MP0005646_abnormal_pituitary_gland2.12283226
17MP0002837_dystrophic_cardiac_calcinosis2.09891505
18MP0002572_abnormal_emotion/affect_behav2.04112465
19MP0002735_abnormal_chemical_nociception2.00598965
20MP0008569_lethality_at_weaning2.00092292
21MP0009046_muscle_twitch1.97701816
22MP0005423_abnormal_somatic_nervous1.97691029
23MP0003705_abnormal_hypodermis_morpholog1.96151565
24MP0004270_analgesia1.94536926
25MP0003436_decreased_susceptibility_to1.92557405
26MP0006276_abnormal_autonomic_nervous1.91842437
27MP0001188_hyperpigmentation1.88988873
28MP0003172_abnormal_lysosome_physiology1.88745930
29MP0002272_abnormal_nervous_system1.85473287
30MP0002822_catalepsy1.83978558
31MP0009840_abnormal_foam_cell1.82609055
32MP0002734_abnormal_mechanical_nocicepti1.82508616
33MP0000604_amyloidosis1.79664852
34MP0003787_abnormal_imprinting1.77010939
35MP0001529_abnormal_vocalization1.73600992
36MP0002638_abnormal_pupillary_reflex1.71983265
37MP0004858_abnormal_nervous_system1.71699763
38MP0010386_abnormal_urinary_bladder1.69909090
39MP0003075_altered_response_to1.68928936
40MP0005645_abnormal_hypothalamus_physiol1.67967843
41MP0001986_abnormal_taste_sensitivity1.65715382
42MP0001970_abnormal_pain_threshold1.64165331
43MP0002067_abnormal_sensory_capabilities1.57861964
44MP0002249_abnormal_larynx_morphology1.56735941
45MP0000013_abnormal_adipose_tissue1.56402052
46MP0003690_abnormal_glial_cell1.54992040
47MP0003879_abnormal_hair_cell1.54646890
48MP0002184_abnormal_innervation1.53306161
49MP0003183_abnormal_peptide_metabolism1.52953836
50MP0006292_abnormal_olfactory_placode1.51903546
51MP0001905_abnormal_dopamine_level1.51032403
52MP0002557_abnormal_social/conspecific_i1.50728861
53MP0004811_abnormal_neuron_physiology1.48830722
54MP0002733_abnormal_thermal_nociception1.47888240
55MP0005394_taste/olfaction_phenotype1.46275567
56MP0005499_abnormal_olfactory_system1.46275567
57MP0000749_muscle_degeneration1.41884814
58MP0001501_abnormal_sleep_pattern1.41126583
59MP0001486_abnormal_startle_reflex1.39294150
60MP0002909_abnormal_adrenal_gland1.38018586
61MP0000778_abnormal_nervous_system1.36470301
62MP0003279_aneurysm1.36360261
63MP0008789_abnormal_olfactory_epithelium1.34453186
64MP0008874_decreased_physiological_sensi1.33538984
65MP0001849_ear_inflammation1.28609079
66MP0000920_abnormal_myelination1.28246748
67MP0003634_abnormal_glial_cell1.27451200
68MP0003191_abnormal_cellular_cholesterol1.26720668
69MP0004215_abnormal_myocardial_fiber1.26574045
70MP0003646_muscle_fatigue1.25198186
71MP0005464_abnormal_platelet_physiology1.24269250
72MP0001348_abnormal_lacrimal_gland1.21914188
73MP0002653_abnormal_ependyma_morphology1.21306975
74MP0001502_abnormal_circadian_rhythm1.18013713
75MP0004084_abnormal_cardiac_muscle1.17313533
76MP0001958_emphysema1.15657075
77MP0005670_abnormal_white_adipose1.15571735
78MP0000631_abnormal_neuroendocrine_gland1.14733486
79MP0004085_abnormal_heartbeat1.13845620
80MP0004510_myositis1.13093640
81MP0003123_paternal_imprinting1.12845796
82MP0005397_hematopoietic_system_phenotyp1.12794587
83MP0001545_abnormal_hematopoietic_system1.12794587
84MP0010030_abnormal_orbit_morphology1.09051222
85MP0001533_abnormal_skeleton_physiology1.08681627
86MP0004142_abnormal_muscle_tone1.07847660
87MP0003300_gastrointestinal_ulcer1.06332213
88MP0005409_darkened_coat_color1.05271633
89MP0004130_abnormal_muscle_cell1.04957043
90MP0005386_behavior/neurological_phenoty1.04790421
91MP0004924_abnormal_behavior1.04790421
92MP0002882_abnormal_neuron_morphology1.04129271
93MP0000015_abnormal_ear_pigmentation1.03825686
94MP0000049_abnormal_middle_ear1.02845663
95MP0002089_abnormal_postnatal_growth/wei1.01771365
96MP0004036_abnormal_muscle_relaxation0.99898206
97MP0002972_abnormal_cardiac_muscle0.98680633
98MP0000343_altered_response_to0.98600751
99MP0005375_adipose_tissue_phenotype0.97471512
100MP0002751_abnormal_autonomic_nervous0.97090762
101MP0003121_genomic_imprinting0.97032935
102MP0005025_abnormal_response_to0.96538127
103MP0003137_abnormal_impulse_conducting0.96423186
104MP0002066_abnormal_motor_capabilities/c0.95646771
105MP0002876_abnormal_thyroid_physiology0.94543384
106MP0005166_decreased_susceptibility_to0.93395253
107MP0005666_abnormal_adipose_tissue0.92743688
108MP0001440_abnormal_grooming_behavior0.91100690
109MP0002127_abnormal_cardiovascular_syste0.90642406
110MP0001270_distended_abdomen0.89765996
111MP0000955_abnormal_spinal_cord0.89246860
112MP0001879_abnormal_lymphatic_vessel0.88499660
113MP0004947_skin_inflammation0.86550604
114MP0002998_abnormal_bone_remodeling0.84997480
115MP0004147_increased_porphyrin_level0.84475259
116MP0005390_skeleton_phenotype0.84376403
117MP0008260_abnormal_autophagy0.82087809
118MP0000003_abnormal_adipose_tissue0.81765889
119MP0002419_abnormal_innate_immunity0.81602077
120MP0005535_abnormal_body_temperature0.80801173
121MP0000681_abnormal_thyroid_gland0.80621452
122MP0003385_abnormal_body_wall0.79715210
123MP0000750_abnormal_muscle_regeneration0.77381754
124MP0003566_abnormal_cell_adhesion0.76635526
125MP0000747_muscle_weakness0.75796900
126MP0005167_abnormal_blood-brain_barrier0.74671131
127MP0008961_abnormal_basal_metabolism0.74418836
128MP0002069_abnormal_eating/drinking_beha0.74389114
129MP0001664_abnormal_digestion0.73095636
130MP0000566_synostosis0.72672845
131MP0002152_abnormal_brain_morphology0.72515549
132MP0005623_abnormal_meninges_morphology0.70717086
133MP0003453_abnormal_keratinocyte_physiol0.70228455
134MP0005671_abnormal_response_to0.69403104
135MP0005000_abnormal_immune_tolerance0.69039084
136MP0002933_joint_inflammation0.68695487
137MP0003091_abnormal_cell_migration0.68108376
138MP0005620_abnormal_muscle_contractility0.68077648
139MP0001790_abnormal_immune_system0.67590574
140MP0005387_immune_system_phenotype0.67590574
141MP0005551_abnormal_eye_electrophysiolog0.67508209
142MP0008004_abnormal_stomach_pH0.67328892
143MP0005451_abnormal_body_composition0.67256804
144MP0001663_abnormal_digestive_system0.67186760
145MP0003633_abnormal_nervous_system0.64991984
146MP0004484_altered_response_of0.64570680
147MP0000858_altered_metastatic_potential0.64540940
148MP0000685_abnormal_immune_system0.63836657
149MP0005257_abnormal_intraocular_pressure0.63458424
150MP0003631_nervous_system_phenotype0.62659558
151MP0003724_increased_susceptibility_to0.61817236
152MP0009780_abnormal_chondrocyte_physiolo0.60377295
153MP0001544_abnormal_cardiovascular_syste0.59879308
154MP0005385_cardiovascular_system_phenoty0.59879308
155MP0000678_abnormal_parathyroid_gland0.58021995
156MP0002752_abnormal_somatic_nervous0.58011744
157MP0000534_abnormal_ureter_morphology0.56940902
158MP0002163_abnormal_gland_morphology0.56559870

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.76077753
2Focal motor seizures (HP:0011153)4.75998454
3Failure to thrive in infancy (HP:0001531)4.24071464
4Obstructive sleep apnea (HP:0002870)4.15801131
5Myokymia (HP:0002411)4.06596955
6Supranuclear gaze palsy (HP:0000605)3.95635271
7Pheochromocytoma (HP:0002666)3.87630112
8Epileptic encephalopathy (HP:0200134)3.84493684
9Neuroendocrine neoplasm (HP:0100634)3.80358124
10Febrile seizures (HP:0002373)3.75350830
11Atonic seizures (HP:0010819)3.74615389
12Neurofibrillary tangles (HP:0002185)3.57429342
13Limb dystonia (HP:0002451)3.11670832
14Polyphagia (HP:0002591)3.11670693
15Cerebral inclusion bodies (HP:0100314)3.01246585
16Progressive cerebellar ataxia (HP:0002073)3.00883709
17Abnormal mitochondria in muscle tissue (HP:0008316)2.97081556
18Hyperventilation (HP:0002883)2.94215394
19Hepatocellular necrosis (HP:0001404)2.92191843
20Acute necrotizing encephalopathy (HP:0006965)2.88613996
21Abnormality of binocular vision (HP:0011514)2.88076015
22Diplopia (HP:0000651)2.88076015
23Oligomenorrhea (HP:0000876)2.84039785
24Peripheral hypomyelination (HP:0007182)2.80222751
25Abnormality of the aortic arch (HP:0012303)2.71871120
26Sleep apnea (HP:0010535)2.67111140
27Mitochondrial inheritance (HP:0001427)2.65495062
28Purpura (HP:0000979)2.65020638
29Focal seizures (HP:0007359)2.64926610
30Abnormal eating behavior (HP:0100738)2.63454373
31Poor suck (HP:0002033)2.60731400
32Anxiety (HP:0000739)2.58973091
33Spinal canal stenosis (HP:0003416)2.58393792
34Distal upper limb amyotrophy (HP:0007149)2.58301956
35Upper limb amyotrophy (HP:0009129)2.58301956
36Hypothermia (HP:0002045)2.57313451
37Hyperacusis (HP:0010780)2.52501013
38Neoplasm of the peripheral nervous system (HP:0100007)2.52429214
39Abnormality of the labia minora (HP:0012880)2.52362620
40Abnormality of the nasal mucosa (HP:0000433)2.51364481
41Neuronal loss in central nervous system (HP:0002529)2.51117420
42Nephrogenic diabetes insipidus (HP:0009806)2.50753689
43Gait imbalance (HP:0002141)2.48963180
44Systemic lupus erythematosus (HP:0002725)2.48017919
45Torticollis (HP:0000473)2.45127352
46Narrow nasal bridge (HP:0000446)2.43390123
47Increased variability in muscle fiber diameter (HP:0003557)2.40870974
48Menstrual irregularities (HP:0000858)2.39218771
49Lissencephaly (HP:0001339)2.36464700
50Generalized hypotonia (HP:0001290)2.36452458
51Depression (HP:0000716)2.34436812
52Hepatic necrosis (HP:0002605)2.33137639
53Hypoventilation (HP:0002791)2.32640298
54Annular pancreas (HP:0001734)2.32196055
55Distal lower limb muscle weakness (HP:0009053)2.31956104
56Dysostosis multiplex (HP:0000943)2.30429378
57Congenital primary aphakia (HP:0007707)2.29863620
58Medial flaring of the eyebrow (HP:0010747)2.29785163
59Nasal polyposis (HP:0100582)2.29043422
60Progressive macrocephaly (HP:0004481)2.28077274
61Axonal loss (HP:0003447)2.26413854
62Absence seizures (HP:0002121)2.26199211
63Increased CSF lactate (HP:0002490)2.25172078
64Eczematoid dermatitis (HP:0000976)2.24747407
65Atelectasis (HP:0100750)2.24542067
66Broad-based gait (HP:0002136)2.23542677
67Insomnia (HP:0100785)2.20979017
68Achilles tendon contracture (HP:0001771)2.19609570
69Distal lower limb amyotrophy (HP:0008944)2.18900824
70Hand muscle atrophy (HP:0009130)2.14800670
71Craniofacial dystonia (HP:0012179)2.13556278
72Stridor (HP:0010307)2.13156501
73Growth hormone excess (HP:0000845)2.11965354
74Sudden death (HP:0001699)2.11921478
75Myotonia (HP:0002486)2.11328274
76Focal dystonia (HP:0004373)2.11165866
77Abnormal EKG (HP:0003115)2.10745049
78Mutism (HP:0002300)2.10187078
79Protrusio acetabuli (HP:0003179)2.10006270
80Prolonged QT interval (HP:0001657)2.09197925
81Amyloidosis (HP:0011034)2.09066603
82Hyperthyroidism (HP:0000836)2.08861732
83Atrial fibrillation (HP:0005110)2.08452995
84Cerebral aneurysm (HP:0004944)2.08180190
85Papilledema (HP:0001085)2.07268976
86Neoplasm of the adrenal gland (HP:0100631)2.06916115
87Primary atrial arrhythmia (HP:0001692)2.06307109
88Hemorrhage of the eye (HP:0011885)2.05650920
89Rapidly progressive (HP:0003678)2.05337924
90Visual hallucinations (HP:0002367)2.05263113
91Heterochromia iridis (HP:0001100)2.04764835
92Supraventricular tachycardia (HP:0004755)2.04694738
93Abnormal gallbladder physiology (HP:0012438)2.04561222
94Cholecystitis (HP:0001082)2.04561222
95Abnormality of skeletal muscle fiber size (HP:0012084)2.04399568
96Abnormality of the metopic suture (HP:0005556)2.03906954
97Neoplasm of head and neck (HP:0012288)2.03070950
98Esophageal neoplasm (HP:0100751)2.03070950
99Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02896135
100Hypoplasia of the brainstem (HP:0002365)2.02896135
101Agitation (HP:0000713)2.02605422
102Abnormality of the Achilles tendon (HP:0005109)2.02515950
103Palpebral edema (HP:0100540)2.02124177
104Impaired pain sensation (HP:0007328)2.00566163
105Abnormality of pain sensation (HP:0010832)2.00566163
106Turricephaly (HP:0000262)2.00083352
107Increased IgE level (HP:0003212)1.99604101
108Increased connective tissue (HP:0009025)1.99283823
109Abnormality of glycolysis (HP:0004366)1.99160403
110Increased serum pyruvate (HP:0003542)1.99160403
111Left ventricular hypertrophy (HP:0001712)1.99084218
112Foot dorsiflexor weakness (HP:0009027)1.98494785
113Nuclear cataract (HP:0100018)1.98203435
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97921099
115Lower limb amyotrophy (HP:0007210)1.96631699
116Difficulty climbing stairs (HP:0003551)1.95815267
117Supraventricular arrhythmia (HP:0005115)1.95491315
118Shallow orbits (HP:0000586)1.94845386
119Hip dysplasia (HP:0001385)1.94790884
120Progressive inability to walk (HP:0002505)1.94298901
121Apathy (HP:0000741)1.93997898
122Diminished motivation (HP:0000745)1.93829336
123Ankle clonus (HP:0011448)1.93442253
124Prolonged bleeding time (HP:0003010)1.92724841
125Myopathic facies (HP:0002058)1.92707145
126Exercise-induced myalgia (HP:0003738)1.92681411
127Nasal speech (HP:0001611)1.92481214
128Specific learning disability (HP:0001328)1.90961069
129Muscle fiber splitting (HP:0003555)1.90380914
130Cellulitis (HP:0100658)1.90328118
131Hyperparathyroidism (HP:0000843)1.90213270
132Calf muscle hypertrophy (HP:0008981)1.90200436
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89637538
134Abnormality of polysaccharide metabolism (HP:0011012)1.89637538
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89637538
136Vertebral compression fractures (HP:0002953)1.89231999
137Mitral regurgitation (HP:0001653)1.89056853
138Abnormality of the calf musculature (HP:0001430)1.86566193
139Emphysema (HP:0002097)1.84728618
140Gaze-evoked nystagmus (HP:0000640)1.83826142
141Dialeptic seizures (HP:0011146)1.83709034
142Long palpebral fissure (HP:0000637)1.83207498
143Poor speech (HP:0002465)1.82689729
144Poor coordination (HP:0002370)1.81963037
145Meningioma (HP:0002858)1.81867699
146Postural instability (HP:0002172)1.81825465
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81464894
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.81395395
149Esotropia (HP:0000565)1.81029643
150Bulbar palsy (HP:0001283)1.81013695
151Abnormality of liposaccharide metabolism (HP:0010968)1.80730823
152Abnormality of glycosphingolipid metabolism (HP:0004343)1.80730823
153Abnormality of glycolipid metabolism (HP:0010969)1.80730823
154Petechiae (HP:0000967)1.80434674
155Palpitations (HP:0001962)1.79840635
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79832535
157Vaginal atresia (HP:0000148)1.79018759
158Bronchomalacia (HP:0002780)1.78646078
159Increased cerebral lipofuscin (HP:0011813)1.78389828
160Dementia (HP:0000726)1.77553776
161Polygenic inheritance (HP:0010982)1.77472789
162Amblyopia (HP:0000646)1.76995916
163Abnormality of the foot musculature (HP:0001436)1.76658824
164Elevated erythrocyte sedimentation rate (HP:0003565)1.76026715
165Acute encephalopathy (HP:0006846)1.75715686
166Ventricular fibrillation (HP:0001663)1.75634048
167Broad face (HP:0000283)1.75586019
168Spastic gait (HP:0002064)1.75423509
169Hypercortisolism (HP:0001578)1.74805309
170Rigidity (HP:0002063)1.74287936
171Abnormality of the vocal cords (HP:0008777)1.73811110
172Genital tract atresia (HP:0001827)1.73573997
173Joint stiffness (HP:0001387)1.73449423
174Asymmetric septal hypertrophy (HP:0001670)1.73140549
175Abnormality of complement system (HP:0005339)1.73002049
176Generalized tonic-clonic seizures (HP:0002069)1.72785078
177Pointed chin (HP:0000307)1.72324484
178Obstructive lung disease (HP:0006536)1.72262023
179Chronic obstructive pulmonary disease (HP:0006510)1.72262023
180Mucopolysacchariduria (HP:0008155)1.72013563
181Large eyes (HP:0001090)1.71737621
182Megalencephaly (HP:0001355)1.69663667
183Protruding tongue (HP:0010808)1.69248197
184Truncal ataxia (HP:0002078)1.68585690
185Optic disc pallor (HP:0000543)1.67489072
186Hypoplastic left heart (HP:0004383)1.65618620
187Neoplasm of the heart (HP:0100544)1.64933449
188Stereotypic behavior (HP:0000733)1.64819026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.81090289
2SIK34.12152625
3MAP3K123.82732600
4ERN13.35516265
5TRIB32.97314544
6PRPF4B2.76503276
7MAP3K112.58170943
8MAP2K72.52454167
9CCNB12.52190700
10MYLK2.38764723
11CDK192.23061986
12MINK12.22272422
13RIPK12.21329937
14DAPK22.04585185
15SIK12.01310695
16DAPK11.92501333
17MARK11.88414034
18ICK1.88148829
19SMG11.85936212
20MARK21.79973494
21MAPK131.79130693
22AKT31.76638883
23EPHB11.75002085
24RIPK41.72306240
25MAP3K41.68868922
26UHMK11.67644795
27NTRK31.65824798
28SGK21.61911056
29LIMK11.55423643
30SGK2231.54591555
31SGK4941.54591555
32EPHA41.51859942
33NTRK21.47786983
34PAK61.47005529
35PRKD21.43581300
36TAOK11.43395112
37PLK21.43130417
38TSSK61.39757576
39BCR1.39147320
40TAOK21.36013382
41MAP4K11.34318085
42PHKG11.26618354
43PHKG21.26618354
44GRK51.23918627
45YES11.20692582
46MAP2K31.14641369
47TXK1.13722722
48NTRK11.13505691
49LMTK21.12112605
50TESK11.11646581
51CAMKK21.10084083
52ADRBK21.07151622
53DYRK1B1.00829611
54HIPK21.00437043
55BMPR1B1.00160831
56MAPK120.99802045
57EIF2AK10.99615799
58PRKD30.99397514
59STK240.99020752
60GRK70.98423396
61TNIK0.97707054
62SGK30.96941458
63EPHB20.95943396
64KDR0.94519346
65PRKCH0.92825951
66DYRK20.92289192
67CDC42BPA0.92051274
68CAMK40.91393531
69EPHA30.91169455
70PKN20.91063369
71NME10.90961167
72CDK50.90185874
73KSR20.89460033
74MAP3K130.88469310
75TYRO30.86246201
76ZAP700.85308418
77MAP2K40.85290842
78PTK60.85226112
79MAP3K60.84710269
80RPS6KA20.83837631
81PDPK10.81994639
82DAPK30.81749816
83MAP3K30.81326542
84TIE10.81075385
85PRKCG0.79166785
86BRAF0.77631330
87FGFR40.77470984
88PIM20.76448803
89PINK10.76136246
90BMX0.75679005
91MAP3K70.74721641
92CDK180.74668927
93CAMK10.74118350
94TESK20.74044191
95ADRBK10.74023972
96FES0.73551809
97ARAF0.73348689
98GRK60.72714686
99MAPK150.71058235
100PKN10.70562007
101CAMKK10.70485729
102DDR20.70162347
103IRAK30.69167595
104STK380.67725526
105CDK140.67561619
106DYRK1A0.66459146
107TTN0.65548825
108PRKCE0.65407298
109PRKD10.65367893
110PTK2B0.62559703
111INSRR0.62222460
112SYK0.62044371
113MAP2K20.61975897
114CAMK2B0.61306851
115CAMK2A0.60733132
116PTK20.59529282
117ERBB30.58238287
118PDK10.57897151
119CDK150.55303963
120ABL20.54734852
121MAPK70.54263626
122FYN0.52610970
123TYK20.52480054
124IRAK20.51965406
125EPHA20.51941839
126CSK0.51852442
127IRAK10.51370237
128CDK11A0.50710053
129CDK80.49770828
130PRKCZ0.49653232
131NME20.49156596
132KSR10.48140597
133PRKG20.48105412
134IRAK40.47954442
135ROCK10.47684534
136BRSK10.47301531
137NLK0.45952817
138OBSCN0.45933737
139RPS6KA60.44833059
140ILK0.44501539
141TBK10.44108905
142RPS6KC10.43583258
143RPS6KL10.43583258
144CLK10.42536255
145ROCK20.40632758
146CAMK2D0.40377050
147DMPK0.39051460
148MAPK40.36770399
149BUB10.35183524
150STK160.34593532
151SIK20.33887241
152MAP3K10.33204367
153CAMK2G0.31548068
154TNK20.31015829

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.58127245
2Collecting duct acid secretion_Homo sapiens_hsa049662.61425763
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43194474
4Olfactory transduction_Homo sapiens_hsa047402.42373065
5Nicotine addiction_Homo sapiens_hsa050332.33267218
6Oxidative phosphorylation_Homo sapiens_hsa001902.16640442
7Circadian entrainment_Homo sapiens_hsa047132.12941225
8Morphine addiction_Homo sapiens_hsa050322.07797828
9Parkinsons disease_Homo sapiens_hsa050122.07235165
10Vibrio cholerae infection_Homo sapiens_hsa051102.01596303
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98038055
12GABAergic synapse_Homo sapiens_hsa047271.97242713
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.81888421
14Dopaminergic synapse_Homo sapiens_hsa047281.79189769
15Notch signaling pathway_Homo sapiens_hsa043301.69927189
16Prion diseases_Homo sapiens_hsa050201.63443018
17* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56129862
18Insulin secretion_Homo sapiens_hsa049111.55078497
19Cardiac muscle contraction_Homo sapiens_hsa042601.53303050
20Amphetamine addiction_Homo sapiens_hsa050311.47261160
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46965455
22Long-term potentiation_Homo sapiens_hsa047201.46896023
23Glutamatergic synapse_Homo sapiens_hsa047241.46335174
24Other glycan degradation_Homo sapiens_hsa005111.46241773
25Cholinergic synapse_Homo sapiens_hsa047251.46170166
26Taste transduction_Homo sapiens_hsa047421.43123872
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41022922
28VEGF signaling pathway_Homo sapiens_hsa043701.40300812
29Alzheimers disease_Homo sapiens_hsa050101.39057121
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38470367
31Serotonergic synapse_Homo sapiens_hsa047261.37892810
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34423472
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34357303
34Phototransduction_Homo sapiens_hsa047441.32906629
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.31796168
36Cocaine addiction_Homo sapiens_hsa050301.25399338
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22736167
38Acute myeloid leukemia_Homo sapiens_hsa052211.20780492
39Osteoclast differentiation_Homo sapiens_hsa043801.19228771
40Huntingtons disease_Homo sapiens_hsa050161.16207932
41Gastric acid secretion_Homo sapiens_hsa049711.15480120
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.14353225
43Proteasome_Homo sapiens_hsa030501.13738632
44Dilated cardiomyopathy_Homo sapiens_hsa054141.13349702
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10887067
46Rheumatoid arthritis_Homo sapiens_hsa053231.09240943
47Calcium signaling pathway_Homo sapiens_hsa040201.07818515
48Salivary secretion_Homo sapiens_hsa049701.06493321
49Gap junction_Homo sapiens_hsa045401.05300654
50Renin secretion_Homo sapiens_hsa049241.01889647
51Oxytocin signaling pathway_Homo sapiens_hsa049211.01471507
52Sulfur relay system_Homo sapiens_hsa041221.00868667
53Long-term depression_Homo sapiens_hsa047300.98782832
54Axon guidance_Homo sapiens_hsa043600.98603108
55B cell receptor signaling pathway_Homo sapiens_hsa046620.96482309
56Phagosome_Homo sapiens_hsa041450.95441561
57Type I diabetes mellitus_Homo sapiens_hsa049400.95207319
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94627058
59cAMP signaling pathway_Homo sapiens_hsa040240.92792001
60Lysosome_Homo sapiens_hsa041420.92018628
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.90729805
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90495366
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89748292
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88930488
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88173351
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86699476
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.84972583
68Chronic myeloid leukemia_Homo sapiens_hsa052200.82828720
69Fructose and mannose metabolism_Homo sapiens_hsa000510.81647011
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80021733
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77955547
72Choline metabolism in cancer_Homo sapiens_hsa052310.76944290
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76821104
74Melanogenesis_Homo sapiens_hsa049160.76760084
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76489844
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75552472
77Phenylalanine metabolism_Homo sapiens_hsa003600.74453598
78Colorectal cancer_Homo sapiens_hsa052100.74079433
79Shigellosis_Homo sapiens_hsa051310.73493594
80Amoebiasis_Homo sapiens_hsa051460.72763814
81Renal cell carcinoma_Homo sapiens_hsa052110.70756417
82Salmonella infection_Homo sapiens_hsa051320.70682418
83Primary immunodeficiency_Homo sapiens_hsa053400.69880984
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69742614
85Tuberculosis_Homo sapiens_hsa051520.69634654
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69474661
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.68940653
88Pertussis_Homo sapiens_hsa051330.68912046
89Non-small cell lung cancer_Homo sapiens_hsa052230.67294641
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67116656
91* AMPK signaling pathway_Homo sapiens_hsa041520.65976497
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65440920
93Hepatitis C_Homo sapiens_hsa051600.65401650
94ErbB signaling pathway_Homo sapiens_hsa040120.64981808
95Galactose metabolism_Homo sapiens_hsa000520.64715994
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64416560
97GnRH signaling pathway_Homo sapiens_hsa049120.64278155
98Pentose phosphate pathway_Homo sapiens_hsa000300.64269232
99Malaria_Homo sapiens_hsa051440.61661309
100Leishmaniasis_Homo sapiens_hsa051400.61405465
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.60516806
102MAPK signaling pathway_Homo sapiens_hsa040100.60215975
103Chemokine signaling pathway_Homo sapiens_hsa040620.59955308
104Regulation of autophagy_Homo sapiens_hsa041400.59767358
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.59615434
106Pancreatic cancer_Homo sapiens_hsa052120.59440346
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57756277
108Endometrial cancer_Homo sapiens_hsa052130.57455593
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56420221
110Bile secretion_Homo sapiens_hsa049760.55709204
111Platelet activation_Homo sapiens_hsa046110.55111422
112Glioma_Homo sapiens_hsa052140.53928010
113Type II diabetes mellitus_Homo sapiens_hsa049300.53344759
114Rap1 signaling pathway_Homo sapiens_hsa040150.52433056
115Asthma_Homo sapiens_hsa053100.51889792
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51673594
117T cell receptor signaling pathway_Homo sapiens_hsa046600.51583506
118Ras signaling pathway_Homo sapiens_hsa040140.51504846
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51453320
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48847392
121* Endocytosis_Homo sapiens_hsa041440.48801448
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45395391
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44427715
124Oocyte meiosis_Homo sapiens_hsa041140.43906681
125Insulin signaling pathway_Homo sapiens_hsa049100.43652817
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43528004
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43408964
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43002848
129Thyroid cancer_Homo sapiens_hsa052160.42848081
130Wnt signaling pathway_Homo sapiens_hsa043100.42647018
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42303563
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41844066
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41471450
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39507507
135Estrogen signaling pathway_Homo sapiens_hsa049150.38186234
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.37946689
137Circadian rhythm_Homo sapiens_hsa047100.37355960
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36261647
139Prolactin signaling pathway_Homo sapiens_hsa049170.35742110

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