ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K4 trimethylation (GO:0080182)	3.80193872
2	positive regulation of gamma-delta T cell activation (GO:0046645)	3.78072361
3	cellular response to ethanol (GO:0071361)	3.75944437
4	interkinetic nuclear migration (GO:0022027)	3.68222207
5	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.67055981
6	histone H3-K36 demethylation (GO:0070544)	3.54136986
7	cellular extravasation (GO:0045123)	3.22287555
8	lipid translocation (GO:0034204)	3.17818077
9	phospholipid translocation (GO:0045332)	3.17818077
10	peptidyl-lysine trimethylation (GO:0018023)	3.13525811
11	detection of molecule of bacterial origin (GO:0032490)	3.11047237
12	regulation of gamma-delta T cell activation (GO:0046643)	3.07164861
13	regulation of gamma-delta T cell differentiation (GO:0045586)	3.01155034
14	positive regulation of developmental pigmentation (GO:0048087)	2.98346216
15	positive regulation of granulocyte differentiation (GO:0030854)	2.95539203
16	cytoplasmic mRNA processing body assembly (GO:0033962)	2.93138652
17	negative regulation of cell killing (GO:0031342)	2.91432617
18	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.91432617
19	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.89478467
20	interleukin-6-mediated signaling pathway (GO:0070102)	2.88557611
21	pericardium development (GO:0060039)	2.87376544
22	nucleus localization (GO:0051647)	2.83306835
23	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.81185319
24	regulation of translation, ncRNA-mediated (GO:0045974)	2.81185319
25	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.81185319
26	early endosome to late endosome transport (GO:0045022)	2.80134379
27	regulation of B cell receptor signaling pathway (GO:0050855)	2.76016883
28	germinal center formation (GO:0002467)	2.74463364
29	regulation of pigment cell differentiation (GO:0050932)	2.73362182
30	B cell receptor signaling pathway (GO:0050853)	2.66555715
31	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.63878752
32	response to interleukin-15 (GO:0070672)	2.59939719
33	establishment of protein localization to Golgi (GO:0072600)	2.58492026
34	embryonic process involved in female pregnancy (GO:0060136)	2.57019874
35	regulation of MHC class I biosynthetic process (GO:0045343)	2.53337524
36	fibroblast migration (GO:0010761)	2.53128352
37	detection of external biotic stimulus (GO:0098581)	2.50907069
38	monoubiquitinated protein deubiquitination (GO:0035520)	2.45046065
39	peptidyl-lysine methylation (GO:0018022)	2.44156363
40	detection of other organism (GO:0098543)	2.42352066
41	centrosome localization (GO:0051642)	2.41207711
42	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	2.40259027
43	histone H3-K4 methylation (GO:0051568)	2.37750204
44	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.37382748
45	histone lysine demethylation (GO:0070076)	2.36319922
46	activated T cell proliferation (GO:0050798)	2.36143364
47	corticosteroid receptor signaling pathway (GO:0031958)	2.35704896
48	peptidyl-threonine phosphorylation (GO:0018107)	2.34043155
49	positive regulation of mast cell activation (GO:0033005)	2.32843781
50	histone H3-K9 modification (GO:0061647)	2.32090339
51	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.31788558
52	macrophage activation involved in immune response (GO:0002281)	2.30498034
53	negative thymic T cell selection (GO:0045060)	2.29892348
54	phospholipid homeostasis (GO:0055091)	2.29168103
55	response to muramyl dipeptide (GO:0032495)	2.28788920
56	neutrophil activation involved in immune response (GO:0002283)	2.27362708
57	histone mRNA catabolic process (GO:0071044)	2.26401384
58	positive regulation of mast cell degranulation (GO:0043306)	2.25663926
59	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.25663926
60	negative regulation of Rho protein signal transduction (GO:0035024)	2.25024578
61	peptidyl-threonine modification (GO:0018210)	2.18759013
62	Golgi to endosome transport (GO:0006895)	2.18728395
63	protein targeting to Golgi (GO:0000042)	2.16760053
64	negative T cell selection (GO:0043383)	2.16035896
65	histone demethylation (GO:0016577)	2.15930729
66	histone H3-K9 methylation (GO:0051567)	2.15879284
67	detection of bacterium (GO:0016045)	2.15137736
68	establishment of nucleus localization (GO:0040023)	2.14008979
69	regulation of membrane lipid distribution (GO:0097035)	2.13369515
70	detection of biotic stimulus (GO:0009595)	2.12579286
71	negative regulation of T cell mediated immunity (GO:0002710)	2.12495052
72	production of molecular mediator involved in inflammatory response (GO:0002532)	2.10420114
73	neural tube formation (GO:0001841)	2.09960710
74	histone H3-K9 demethylation (GO:0033169)	2.09135455
75	CD4-positive, alpha-beta T cell differentiation (GO:0043367)	2.07890274
76	neutrophil mediated immunity (GO:0002446)	2.07437625
77	regulation of granulocyte differentiation (GO:0030852)	2.07087362
78	negative regulation of lymphocyte mediated immunity (GO:0002707)	2.05676211
79	regulation of histone H3-K27 methylation (GO:0061085)	2.05559302
80	auditory receptor cell differentiation (GO:0042491)	2.05546389
81	histone lysine methylation (GO:0034968)	2.05506941
82	regulation of hippo signaling (GO:0035330)	2.04513955
83	interferon-gamma production (GO:0032609)	2.04113840
84	negative regulation of complement activation (GO:0045916)	2.03857185
85	mannose metabolic process (GO:0006013)	2.03706870
86	regulation of hypersensitivity (GO:0002883)	2.03367833
87	myeloid leukocyte mediated immunity (GO:0002444)	2.02921416
88	cellular response to interleukin-15 (GO:0071350)	2.02801271
89	modulation by symbiont of host defense response (GO:0052031)	2.02414403
90	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.02414403
91	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.02414403
92	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.02414403
93	modulation by symbiont of host immune response (GO:0052553)	2.02414403
94	positive regulation by symbiont of host defense response (GO:0052509)	2.02414403
95	regulation of necroptotic process (GO:0060544)	2.02279669
96	pre-miRNA processing (GO:0031054)	2.02141710
97	peptidyl-serine phosphorylation (GO:0018105)	2.02114960
98	regulation of mast cell activation (GO:0033003)	2.01944239
99	regulation of alkaline phosphatase activity (GO:0010692)	2.01840570
100	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.00771968

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.15657610
2	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.08169531
3	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.94516023
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.78219325
5	GATA1_22025678_ChIP-Seq_K562_Human	2.61919899
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.54022946
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.45263568
8	RUNX_20019798_ChIP-Seq_JUKART_Human	2.02022076
9	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.99311086
10	GBX2_23144817_ChIP-Seq_PC3_Human	1.94818449
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.94552115
12	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.92321830
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.88078529
14	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.87204509
15	SCL_19346495_ChIP-Seq_HPC-7_Human	1.83886681
16	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.83008798
17	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.79710740
18	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.75115325
19	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.74334653
20	TP53_16413492_ChIP-PET_HCT116_Human	1.72850605
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71084242
22	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.67299937
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.65103933
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.64707632
25	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.62763018
26	AHR_22903824_ChIP-Seq_MCF-7_Human	1.60966037
27	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.60378208
28	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.60104324
29	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.60009700
30	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.55250413
31	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.52228526
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.51008870
33	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.49052430
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47066610
35	VDR_24787735_ChIP-Seq_THP-1_Human	1.43599439
36	SPI1_23127762_ChIP-Seq_K562_Human	1.40874074
37	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38184090
38	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.38088619
39	STAT3_23295773_ChIP-Seq_U87_Human	1.35925518
40	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.29258806
41	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.29258806
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28907010
43	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.28879738
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27674115
45	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.27371425
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25979976
47	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.25563876
48	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.23685246
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23221469
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.21680352
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21370582
52	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.20175408
53	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.17690017
54	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.17590880
55	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.17356862
56	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.16318536
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16280678
58	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.16186585
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.14899380
60	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.13217315
61	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.13093463
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12625184
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12625184
64	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.11927692
65	TCF4_23295773_ChIP-Seq_U87_Human	1.10751938
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09364774
67	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09329576
68	DROSHA_22980978_ChIP-Seq_HELA_Human	1.08867767
69	RXR_22108803_ChIP-Seq_LS180_Human	1.08786862
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08344762
71	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07974448
72	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.07295110
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06276209
74	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.04522211
75	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.02347271
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01364834
77	MYB_26560356_Chip-Seq_TH2_Human	1.00188409
78	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.99819604
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97406918
80	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96967829
81	GATA3_27048872_Chip-Seq_THYMUS_Human	0.96735641
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96689739
83	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.95509511
84	TP63_23658742_ChIP-Seq_EP156T_Human	0.95023384
85	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.94969555
86	BRD4_25478319_ChIP-Seq_HGPS_Human	0.94601454
87	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.94398521
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93844290
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.93831127
90	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.93817850
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93578247
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93309238
93	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92896068
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92696959
95	PU_27001747_Chip-Seq_BMDM_Mouse	0.91769541
96	KDM2B_26808549_Chip-Seq_REH_Human	0.91339867
97	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.90326557
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.89125661
99	P300_19829295_ChIP-Seq_ESCs_Human	0.88897406
100	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.88888233

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.11343694
2	MP0008057_abnormal_DNA_replication	3.73298445
3	MP0003724_increased_susceptibility_to	2.52484713
4	MP0003172_abnormal_lysosome_physiology	2.51965389
5	MP0001835_abnormal_antigen_presentation	2.48492943
6	MP0003191_abnormal_cellular_cholesterol	2.31308021
7	MP0002254_reproductive_system_inflammat	2.22611049
8	MP0004264_abnormal_extraembryonic_tissu	2.17620072
9	MP0003763_abnormal_thymus_physiology	1.97364424
10	MP0003045_fibrosis	1.97017500
11	MP0005275_abnormal_skin_tensile	1.92244666
12	MP0005174_abnormal_tail_pigmentation	1.91890068
13	MP0000383_abnormal_hair_follicle	1.87044525
14	MP0005409_darkened_coat_color	1.81730223
15	MP0003436_decreased_susceptibility_to	1.77976977
16	MP0000465_gastrointestinal_hemorrhage	1.76600651
17	MP0004084_abnormal_cardiac_muscle	1.76145417
18	MP0003221_abnormal_cardiomyocyte_apopto	1.74421749
19	MP0003303_peritoneal_inflammation	1.74384182
20	MP0003828_pulmonary_edema	1.73146002
21	MP0008961_abnormal_basal_metabolism	1.71603966
22	MP0004381_abnormal_hair_follicle	1.65832970
23	MP0003091_abnormal_cell_migration	1.64473271
24	MP0003566_abnormal_cell_adhesion	1.64194891
25	MP0001800_abnormal_humoral_immune	1.64034069
26	MP0001986_abnormal_taste_sensitivity	1.61355637
27	MP0002396_abnormal_hematopoietic_system	1.57234413
28	MP0004484_altered_response_of	1.49578157
29	MP0001790_abnormal_immune_system	1.49438945
30	MP0005387_immune_system_phenotype	1.49438945
31	MP0005076_abnormal_cell_differentiation	1.49355423
32	MP0004130_abnormal_muscle_cell	1.48619921
33	MP0003300_gastrointestinal_ulcer	1.47679243
34	MP0002419_abnormal_innate_immunity	1.46699438
35	MP0000015_abnormal_ear_pigmentation	1.39870905
36	MP0001958_emphysema	1.39772328
37	MP0000371_diluted_coat_color	1.38212999
38	MP0003656_abnormal_erythrocyte_physiolo	1.37550837
39	MP0004947_skin_inflammation	1.26862348
40	MP0005464_abnormal_platelet_physiology	1.26677141
41	MP0000427_abnormal_hair_cycle	1.25720200
42	MP0002405_respiratory_system_inflammati	1.24942065
43	MP0004036_abnormal_muscle_relaxation	1.24701914
44	MP0003690_abnormal_glial_cell	1.22877937
45	MP0002127_abnormal_cardiovascular_syste	1.22860106
46	MP0003890_abnormal_embryonic-extraembry	1.22737425
47	MP0001915_intracranial_hemorrhage	1.22086064
48	MP0002168_other_aberrant_phenotype	1.21292934
49	MP0000685_abnormal_immune_system	1.20044316
50	MP0002723_abnormal_immune_serum	1.19074267
51	MP0005310_abnormal_salivary_gland	1.16595341
52	MP0008004_abnormal_stomach_pH	1.14181528
53	MP0010368_abnormal_lymphatic_system	1.13966261
54	MP0002420_abnormal_adaptive_immunity	1.13156876
55	MP0008260_abnormal_autophagy	1.12028896
56	MP0001819_abnormal_immune_cell	1.11834765
57	MP0004883_abnormal_blood_vessel	1.11611076
58	MP0002452_abnormal_antigen_presenting	1.09779299
59	MP0000733_abnormal_muscle_development	1.09518372
60	MP0002009_preneoplasia	1.09039496
61	MP0002998_abnormal_bone_remodeling	1.07370138
62	MP0004134_abnormal_chest_morphology	1.07359435
63	MP0005000_abnormal_immune_tolerance	1.07307087
64	MP0002398_abnormal_bone_marrow	1.07259003
65	MP0006138_congestive_heart_failure	1.05214711
66	MP0010678_abnormal_skin_adnexa	1.03913631
67	MP0009115_abnormal_fat_cell	1.03891474
68	MP0003279_aneurysm	1.02443646
69	MP0000716_abnormal_immune_system	1.00365941
70	MP0005025_abnormal_response_to	0.99772399
71	MP0000767_abnormal_smooth_muscle	0.99034457
72	MP0004510_myositis	0.98895434
73	MP0006082_CNS_inflammation	0.98110244
74	MP0010352_gastrointestinal_tract_polyps	0.97271913
75	MP0002925_abnormal_cardiovascular_devel	0.97204515
76	MP0003868_abnormal_feces_composition	0.94486046
77	MP0004808_abnormal_hematopoietic_stem	0.93333428
78	MP0003115_abnormal_respiratory_system	0.92634958
79	MP0001533_abnormal_skeleton_physiology	0.92560668
80	MP0005451_abnormal_body_composition	0.90931949
81	MP0006054_spinal_hemorrhage	0.89615644
82	MP0002166_altered_tumor_susceptibility	0.89580836
83	MP0002332_abnormal_exercise_endurance	0.87262615
84	MP0003705_abnormal_hypodermis_morpholog	0.85602008
85	MP0000639_abnormal_adrenal_gland	0.85319998
86	MP0005621_abnormal_cell_physiology	0.83109427
87	MP0003183_abnormal_peptide_metabolism	0.81720248
88	MP0000703_abnormal_thymus_morphology	0.81387330
89	MP0002108_abnormal_muscle_morphology	0.80802823
90	MP0002133_abnormal_respiratory_system	0.79897763
91	MP0005388_respiratory_system_phenotype	0.79897763
92	MP0000689_abnormal_spleen_morphology	0.79278678
93	MP0000013_abnormal_adipose_tissue	0.79023980
94	MP0008438_abnormal_cutaneous_collagen	0.76369365
95	MP0001175_abnormal_lung_morphology	0.76042322
96	MP0002722_abnormal_immune_system	0.75814530
97	MP0002128_abnormal_blood_circulation	0.74247363
98	MP0001545_abnormal_hematopoietic_system	0.74201766
99	MP0005397_hematopoietic_system_phenotyp	0.74201766
100	MP0003252_abnormal_bile_duct	0.74033518

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the fingertips (HP:0001211)	3.51647433
2	Genetic anticipation (HP:0003743)	3.40512950
3	Papillary thyroid carcinoma (HP:0002895)	3.01997563
4	Amyotrophic lateral sclerosis (HP:0007354)	2.78802782
5	Gingival bleeding (HP:0000225)	2.78082441
6	Aortic aneurysm (HP:0004942)	2.65821749
7	Spondylolisthesis (HP:0003302)	2.63015119
8	Facial diplegia (HP:0001349)	2.60797660
9	T lymphocytopenia (HP:0005403)	2.55164157
10	Widely spaced teeth (HP:0000687)	2.52632547
11	Gaze-evoked nystagmus (HP:0000640)	2.52505928
12	Narrow palate (HP:0000189)	2.51151424
13	Spontaneous hematomas (HP:0007420)	2.43588053
14	Fair hair (HP:0002286)	2.40480869
15	Abnormality of T cell number (HP:0011839)	2.40241902
16	Tented upper lip vermilion (HP:0010804)	2.36497764
17	Abnormality of the columella (HP:0009929)	2.35955595
18	Hyperventilation (HP:0002883)	2.35341117
19	Abnormality of the lower motor neuron (HP:0002366)	2.34306765
20	Absent speech (HP:0001344)	2.33026965
21	Eczematoid dermatitis (HP:0000976)	2.31805351
22	Arterial tortuosity (HP:0005116)	2.31201074
23	Heterotopia (HP:0002282)	2.26484005
24	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.26197665
25	Hepatoblastoma (HP:0002884)	2.24146138
26	Abnormal hair whorl (HP:0010721)	2.24138817
27	Conjunctival telangiectasia (HP:0000524)	2.23550777
28	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.22207710
29	Prolonged bleeding time (HP:0003010)	2.20216581
30	Recurrent bacterial skin infections (HP:0005406)	2.18781885
31	Protruding tongue (HP:0010808)	2.17564011
32	Hematochezia (HP:0002573)	2.17173815
33	Abnormality of the pubic bones (HP:0003172)	2.16057853
34	Recurrent cutaneous fungal infections (HP:0011370)	2.14890807
35	Chronic mucocutaneous candidiasis (HP:0002728)	2.14890807
36	Tapered finger (HP:0001182)	2.14805701
37	Upper motor neuron abnormality (HP:0002127)	2.12168388
38	Myositis (HP:0100614)	2.11879790
39	Aortic dissection (HP:0002647)	2.07035974
40	Colitis (HP:0002583)	2.05925529
41	Submucous cleft hard palate (HP:0000176)	2.05086546
42	Truncal obesity (HP:0001956)	2.02045300
43	Broad face (HP:0000283)	2.01411332
44	Vascular tortuosity (HP:0004948)	2.00324055
45	Progressive cerebellar ataxia (HP:0002073)	1.97948916
46	Gingivitis (HP:0000230)	1.97512885
47	Anteriorly placed anus (HP:0001545)	1.97478457
48	Neoplasm of the heart (HP:0100544)	1.96231619
49	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.94532866
50	Abnormality of incisor morphology (HP:0011063)	1.93354348
51	Coarse hair (HP:0002208)	1.93255024
52	Stomach cancer (HP:0012126)	1.93171834
53	Peritonitis (HP:0002586)	1.92577172
54	Abnormality of the axillary hair (HP:0100134)	1.91436551
55	Abnormality of secondary sexual hair (HP:0009888)	1.91436551
56	Macroorchidism (HP:0000053)	1.89863562
57	Laryngomalacia (HP:0001601)	1.89013520
58	Recurrent abscess formation (HP:0002722)	1.88830399
59	Ectropion (HP:0000656)	1.88315605
60	Generalized hypopigmentation of hair (HP:0011358)	1.88228043
61	Long eyelashes (HP:0000527)	1.84189706
62	Thick eyebrow (HP:0000574)	1.83727305
63	Epistaxis (HP:0000421)	1.82707808
64	Recurrent fungal infections (HP:0002841)	1.82551607
65	Papilledema (HP:0001085)	1.82195351
66	Abnormality of the nasal septum (HP:0000419)	1.81112616
67	Optic neuritis (HP:0100653)	1.78897555
68	Retrobulbar optic neuritis (HP:0100654)	1.78897555
69	Subacute progressive viral hepatitis (HP:0006572)	1.77747420
70	Menorrhagia (HP:0000132)	1.76005516
71	Orchitis (HP:0100796)	1.75577292
72	Impaired vibratory sensation (HP:0002495)	1.73195116
73	Supernumerary ribs (HP:0005815)	1.72897258
74	Gastrointestinal infarctions (HP:0005244)	1.71582282
75	Inflammation of the large intestine (HP:0002037)	1.71333322
76	Cerebral aneurysm (HP:0004944)	1.70837037
77	Recurrent skin infections (HP:0001581)	1.70359764
78	Decreased lacrimation (HP:0000633)	1.69779285
79	Overgrowth (HP:0001548)	1.69525431
80	Prominent nose (HP:0000448)	1.68510596
81	Pustule (HP:0200039)	1.68417849
82	Stomatitis (HP:0010280)	1.67878483
83	Increased IgE level (HP:0003212)	1.65193641
84	Broad ribs (HP:0000885)	1.64622407
85	Viral hepatitis (HP:0006562)	1.64373873
86	Low anterior hairline (HP:0000294)	1.64130632
87	Clonus (HP:0002169)	1.64017362
88	Aneurysm (HP:0002617)	1.62921502
89	Acute myeloid leukemia (HP:0004808)	1.62729057
90	Thyroid carcinoma (HP:0002890)	1.61671031
91	Lower limb muscle weakness (HP:0007340)	1.61630949
92	Dislocated radial head (HP:0003083)	1.61098400
93	Blue irides (HP:0000635)	1.60958601
94	Excessive salivation (HP:0003781)	1.60051974
95	Cupped ear (HP:0000378)	1.59621245
96	Pulmonary artery stenosis (HP:0004415)	1.59027843
97	Hypoplasia of the maxilla (HP:0000327)	1.59023102
98	Absent frontal sinuses (HP:0002688)	1.58954023
99	Hypoplastic labia majora (HP:0000059)	1.58524151
100	Clumsiness (HP:0002312)	1.57938459

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	2.66020741
2	MAP3K6	2.30905201
3	FRK	2.18303781
4	MAP4K2	2.15348072
5	AKT3	2.08096141
6	BLK	1.95218260
7	SGK2	1.91429902
8	FGFR3	1.83835390
9	TYK2	1.77766285
10	CAMK1D	1.72418029
11	WNK1	1.68673543
12	MAP3K7	1.67530066
13	MARK2	1.64565886
14	CAMK1G	1.62304694
15	MAP3K4	1.60828684
16	JAK1	1.53280469
17	FGFR4	1.51873841
18	MAP2K4	1.47239883
19	SGK3	1.45892118
20	PKN2	1.37837470
21	RIPK4	1.37272430
22	MAP4K1	1.36636429
23	MAP2K3	1.33775109
24	FGFR2	1.33548341
25	CDK6	1.33492029
26	CDC42BPA	1.32800973
27	BRD4	1.31265545
28	CDK12	1.29892131
29	PINK1	1.29059610
30	ZAP70	1.27972891
31	EPHA3	1.25046264
32	SGK223	1.22957212
33	SGK494	1.22957212
34	BTK	1.21787524
35	TNK2	1.17033154
36	OBSCN	1.15569454
37	RET	1.14745447
38	PDGFRA	1.13859233
39	JAK3	1.11065656
40	HCK	1.10904689
41	CAMK4	1.04578804
42	STK38	1.03932631
43	TRPM7	1.03612893
44	PIK3CG	1.02506520
45	IKBKE	1.02329657
46	YES1	1.01572868
47	EPHB1	1.01361235
48	ERN1	1.00574043
49	PTK2B	0.98461353
50	NEK9	0.96396629
51	NLK	0.96223306
52	ITK	0.92797851
53	TEC	0.90770902
54	TRIB3	0.90541967
55	SYK	0.90005524
56	ACVR1B	0.89361348
57	TTN	0.88153846
58	FGR	0.86706535
59	JAK2	0.86575753
60	CSK	0.86149379
61	MAP2K7	0.86072525
62	CHUK	0.85718516
63	PDGFRB	0.84177066
64	MAP3K2	0.83261445
65	ICK	0.82580477
66	SIK3	0.81145442
67	PRKD2	0.79488869
68	MAP3K14	0.79046418
69	PIK3CA	0.77894465
70	MAP3K5	0.76840630
71	KIT	0.76043678
72	MELK	0.75693968
73	DAPK2	0.74002255
74	SIK2	0.72981443
75	PRKAA2	0.71991765
76	MAPK7	0.71587660
77	LCK	0.70865673
78	NTRK2	0.68340269
79	DYRK3	0.67518092
80	NEK6	0.67013757
81	MAP3K10	0.66712563
82	MET	0.66710869
83	CDK4	0.66365962
84	BCR	0.64001799
85	GRK6	0.63944951
86	FLT3	0.62832544
87	FES	0.59914511
88	PDK1	0.58480790
89	TNIK	0.53890805
90	TXK	0.53563646
91	LYN	0.53087980
92	EGFR	0.51827283
93	MARK1	0.50036742
94	DYRK1A	0.50003614
95	STK11	0.49359020
96	SGK1	0.49290562
97	MARK3	0.48461274
98	CSNK1A1L	0.48188103
99	MAPK12	0.48176176
100	LATS1	0.47589471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.61247738
2	Osteoclast differentiation_Homo sapiens_hsa04380	1.57201439
3	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.50976966
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.45838498
5	Acute myeloid leukemia_Homo sapiens_hsa05221	1.45264619
6	Platelet activation_Homo sapiens_hsa04611	1.37901051
7	Prolactin signaling pathway_Homo sapiens_hsa04917	1.32887874
8	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.31780108
9	Choline metabolism in cancer_Homo sapiens_hsa05231	1.28611872
10	Non-small cell lung cancer_Homo sapiens_hsa05223	1.28301968
11	ABC transporters_Homo sapiens_hsa02010	1.24946034
12	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.24583371
13	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.23753694
14	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.23701760
15	Notch signaling pathway_Homo sapiens_hsa04330	1.23074539
16	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.20280151
17	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.19767019
18	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.16171359
19	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.16106329
20	Tuberculosis_Homo sapiens_hsa05152	1.16044307
21	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.15646346
22	FoxO signaling pathway_Homo sapiens_hsa04068	1.11488889
23	TNF signaling pathway_Homo sapiens_hsa04668	1.10041882
24	mTOR signaling pathway_Homo sapiens_hsa04150	1.09513545
25	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.09481635
26	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.08260134
27	Toxoplasmosis_Homo sapiens_hsa05145	1.07815810
28	Endometrial cancer_Homo sapiens_hsa05213	1.06295335
29	Leishmaniasis_Homo sapiens_hsa05140	1.06050800
30	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.05449847
31	Lysine degradation_Homo sapiens_hsa00310	1.05191003
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.04117962
33	Circadian rhythm_Homo sapiens_hsa04710	1.04077190
34	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.03845584
35	Pancreatic cancer_Homo sapiens_hsa05212	1.03052165
36	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.01976333
37	GnRH signaling pathway_Homo sapiens_hsa04912	1.01926712
38	Renal cell carcinoma_Homo sapiens_hsa05211	1.01104128
39	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.00793614
40	Malaria_Homo sapiens_hsa05144	1.00459193
41	Insulin resistance_Homo sapiens_hsa04931	1.00313149
42	ErbB signaling pathway_Homo sapiens_hsa04012	0.98798415
43	Hepatitis C_Homo sapiens_hsa05160	0.98247036
44	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.97915089
45	Colorectal cancer_Homo sapiens_hsa05210	0.95969850
46	Hepatitis B_Homo sapiens_hsa05161	0.95583658
47	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.94225756
48	Glioma_Homo sapiens_hsa05214	0.93499060
49	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.91778909
50	Adherens junction_Homo sapiens_hsa04520	0.91012139
51	Influenza A_Homo sapiens_hsa05164	0.90956440
52	Chemokine signaling pathway_Homo sapiens_hsa04062	0.90120593
53	Measles_Homo sapiens_hsa05162	0.88689342
54	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.88467689
55	Focal adhesion_Homo sapiens_hsa04510	0.87615791
56	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.87581284
57	Prostate cancer_Homo sapiens_hsa05215	0.86298875
58	Complement and coagulation cascades_Homo sapiens_hsa04610	0.84785148
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83023023
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.80176100
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.79435213
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.79112657
63	Type II diabetes mellitus_Homo sapiens_hsa04930	0.75123922
64	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.74972098
65	Amoebiasis_Homo sapiens_hsa05146	0.74614466
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.73090422
67	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.72903230
68	Proteoglycans in cancer_Homo sapiens_hsa05205	0.72607424
69	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70105307
70	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.69953999
71	Small cell lung cancer_Homo sapiens_hsa05222	0.69811807
72	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.69147735
73	Insulin signaling pathway_Homo sapiens_hsa04910	0.68688864
74	Estrogen signaling pathway_Homo sapiens_hsa04915	0.67549334
75	MAPK signaling pathway_Homo sapiens_hsa04010	0.66579349
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.65913066
77	Ras signaling pathway_Homo sapiens_hsa04014	0.65572131
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.65113194
79	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.65067275
80	Taste transduction_Homo sapiens_hsa04742	0.65029324
81	Other glycan degradation_Homo sapiens_hsa00511	0.62866123
82	Rap1 signaling pathway_Homo sapiens_hsa04015	0.61500760
83	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.61225750
84	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.61156827
85	ECM-receptor interaction_Homo sapiens_hsa04512	0.60539299
86	Pertussis_Homo sapiens_hsa05133	0.60416561
87	Long-term potentiation_Homo sapiens_hsa04720	0.60189995
88	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59768537
89	Herpes simplex infection_Homo sapiens_hsa05168	0.59286916
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.58811349
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58696605
92	VEGF signaling pathway_Homo sapiens_hsa04370	0.58666983
93	Renin secretion_Homo sapiens_hsa04924	0.58360114
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.58341921
95	Axon guidance_Homo sapiens_hsa04360	0.58031463
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.57670301
97	Long-term depression_Homo sapiens_hsa04730	0.57104132
98	African trypanosomiasis_Homo sapiens_hsa05143	0.56184933
99	Viral myocarditis_Homo sapiens_hsa05416	0.54970145
100	Pathways in cancer_Homo sapiens_hsa05200	0.54831523

RAB11FIP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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