RAB11FIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.50356229
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28329700
3vocalization behavior (GO:0071625)4.08715963
4synaptic vesicle maturation (GO:0016188)3.97945644
5semaphorin-plexin signaling pathway (GO:0071526)3.96084764
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.93768433
7cellular potassium ion homeostasis (GO:0030007)3.89483917
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.88650974
9phosphate ion transport (GO:0006817)3.87709356
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86404683
11protein carboxylation (GO:0018214)3.80127679
12peptidyl-glutamic acid carboxylation (GO:0017187)3.80127679
13sodium ion export (GO:0071436)3.77958092
14drug transmembrane transport (GO:0006855)3.72503509
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65707432
16aminoglycoside antibiotic metabolic process (GO:0030647)3.59118158
17regulation of glutamate receptor signaling pathway (GO:1900449)3.57982163
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.55782967
19glutamate secretion (GO:0014047)3.47802192
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45011187
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.39082536
22cell-cell junction maintenance (GO:0045217)3.34880720
23regulation of synapse structural plasticity (GO:0051823)3.30993832
24synaptic vesicle exocytosis (GO:0016079)3.30794758
25layer formation in cerebral cortex (GO:0021819)3.28502121
26exploration behavior (GO:0035640)3.26630363
27urate metabolic process (GO:0046415)3.25433409
28phosphate ion transmembrane transport (GO:0035435)3.24727496
29cell communication by electrical coupling (GO:0010644)3.23285628
30organic cation transport (GO:0015695)3.23184559
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22693119
32negative regulation of catenin import into nucleus (GO:0035414)3.21101015
33adenosine receptor signaling pathway (GO:0001973)3.20787805
34neurotransmitter secretion (GO:0007269)3.20417485
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16743641
36regulation of synaptic vesicle exocytosis (GO:2000300)3.15943203
37regulation of skeletal muscle contraction (GO:0014819)3.14224118
38regulation of neuronal synaptic plasticity (GO:0048168)3.13595610
39protein retention in ER lumen (GO:0006621)3.13355530
40dendritic spine morphogenesis (GO:0060997)3.11505815
41neuronal action potential propagation (GO:0019227)3.11058634
42cerebellar granule cell differentiation (GO:0021707)3.10174867
43quaternary ammonium group transport (GO:0015697)3.10110521
44lysine catabolic process (GO:0006554)3.09927380
45lysine metabolic process (GO:0006553)3.09927380
46mannose metabolic process (GO:0006013)3.02289666
47protein localization to synapse (GO:0035418)3.00911396
48regulation of synapse maturation (GO:0090128)3.00894330
49potassium ion import (GO:0010107)3.00327640
50postsynaptic membrane organization (GO:0001941)2.97991198
51regulation of synaptic vesicle transport (GO:1902803)2.97798478
52drug transport (GO:0015893)2.95968879
53synaptic transmission, glutamatergic (GO:0035249)2.95073193
54regulation of dendritic spine morphogenesis (GO:0061001)2.94471740
55gamma-aminobutyric acid transport (GO:0015812)2.92313231
56positive regulation of membrane potential (GO:0045838)2.91919799
57synaptic vesicle endocytosis (GO:0048488)2.91623122
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91378807
59dendrite morphogenesis (GO:0048813)2.90756761
60exogenous drug catabolic process (GO:0042738)2.89538281
61metanephric nephron tubule development (GO:0072234)2.88404526
62metanephric tubule development (GO:0072170)2.88404526
63proline transport (GO:0015824)2.88035412
64glutamate receptor signaling pathway (GO:0007215)2.87891008
65neuron cell-cell adhesion (GO:0007158)2.86032172
66negative regulation of fatty acid transport (GO:2000192)2.82982336
67drug catabolic process (GO:0042737)2.82080791
68cellular response to ATP (GO:0071318)2.81859464
69GDP-mannose metabolic process (GO:0019673)2.81521631
70neurotransmitter transport (GO:0006836)2.77948408
71positive regulation of synapse maturation (GO:0090129)2.77379196
72adherens junction assembly (GO:0034333)2.77156711
73neuromuscular process controlling balance (GO:0050885)2.76385699
74regulation of ARF protein signal transduction (GO:0032012)2.75106207
75membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.75059264
76cellular sodium ion homeostasis (GO:0006883)2.73376644
77positive regulation of protein kinase C signaling (GO:0090037)2.72812720
78glycine transport (GO:0015816)2.70886172
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70743522
80metanephric nephron epithelium development (GO:0072243)2.69716018
81adenine nucleotide transport (GO:0051503)2.69602905
82neuron recognition (GO:0008038)2.69193057
83regulation of ARF GTPase activity (GO:0032312)2.68278321
84neuron-neuron synaptic transmission (GO:0007270)2.67018676
85regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66940037
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.65926673
87cell-substrate adherens junction assembly (GO:0007045)2.65789006
88focal adhesion assembly (GO:0048041)2.65789006
89basement membrane organization (GO:0071711)2.64435447
90regulation of cholesterol biosynthetic process (GO:0045540)2.64205815
91cell junction maintenance (GO:0034331)2.63212117
92long-term memory (GO:0007616)2.62450411
93carnitine transport (GO:0015879)2.60874566
94amino-acid betaine transport (GO:0015838)2.60874566
95neurotransmitter-gated ion channel clustering (GO:0072578)2.57784683
96auditory behavior (GO:0031223)2.57526869
97convergent extension (GO:0060026)2.57313815
98axon ensheathment in central nervous system (GO:0032291)2.56751255
99central nervous system myelination (GO:0022010)2.56751255
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56267387
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55543339
102L-amino acid import (GO:0043092)2.55430104
103endothelial cell chemotaxis (GO:0035767)2.54758707
104plasma membrane repair (GO:0001778)2.53636686
105potassium ion homeostasis (GO:0055075)2.53533687
106regulation of postsynaptic membrane potential (GO:0060078)2.52777946
107urinary tract smooth muscle contraction (GO:0014848)2.52568835
108establishment of nucleus localization (GO:0040023)2.50732962
109membrane repolarization (GO:0086009)2.50654430
110cell communication involved in cardiac conduction (GO:0086065)2.50587933
111activation of protein kinase A activity (GO:0034199)2.50377687
112response to parathyroid hormone (GO:0071107)2.50369525
113metanephric epithelium development (GO:0072207)2.46692567
114axonal fasciculation (GO:0007413)2.46084740
115aspartate family amino acid catabolic process (GO:0009068)2.45983379
116regulation of synaptic plasticity (GO:0048167)2.45716800
117dopamine receptor signaling pathway (GO:0007212)2.45693727
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45356914
119membrane repolarization during action potential (GO:0086011)2.44847661
120dendritic spine organization (GO:0097061)2.44500582
121regulation of glycogen (starch) synthase activity (GO:2000465)2.43736654
122regulation of fatty acid beta-oxidation (GO:0031998)2.42387398
123regulation of neurotransmitter levels (GO:0001505)2.42368152
124membrane depolarization during action potential (GO:0086010)2.41515786
125regulation of dendritic spine development (GO:0060998)2.40744535
126regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40374894
127membrane hyperpolarization (GO:0060081)2.40021033
128proline biosynthetic process (GO:0006561)2.40015962
129response to mercury ion (GO:0046689)2.39989853
130sensory perception of taste (GO:0050909)2.38608746
131regulation of clathrin-mediated endocytosis (GO:2000369)2.37463469
132regulation of early endosome to late endosome transport (GO:2000641)2.36615789
133tricarboxylic acid metabolic process (GO:0072350)2.36080417
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.35528108
135neuronal ion channel clustering (GO:0045161)2.34777633
136cerebellar Purkinje cell differentiation (GO:0021702)2.33648735
137camera-type eye morphogenesis (GO:0048593)2.33451797
138positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.33223851
139positive regulation of axonogenesis (GO:0050772)2.32999711
140cellular response to ammonium ion (GO:0071242)2.32585369
141neuromuscular synaptic transmission (GO:0007274)2.32537922
142cell migration in hindbrain (GO:0021535)2.32492169
143positive regulation of potassium ion transmembrane transport (GO:1901381)2.32086830
144regulation of mammary gland epithelial cell proliferation (GO:0033599)2.30879493
145atrioventricular valve morphogenesis (GO:0003181)2.30311170
146neuromuscular junction development (GO:0007528)2.29938074
147amino acid import (GO:0043090)2.29924483
148negative regulation of cell size (GO:0045792)2.29676609
149purine nucleotide transport (GO:0015865)2.28983236
150lung epithelium development (GO:0060428)2.28424875
151positive regulation of dendrite development (GO:1900006)2.26694469
152regulation of cholesterol metabolic process (GO:0090181)2.25604358
153protein targeting to plasma membrane (GO:0072661)2.20710203
154positive regulation of dendritic spine development (GO:0060999)2.19978663
155proline metabolic process (GO:0006560)2.19411102
156actin filament bundle organization (GO:0061572)2.19285249
157actin filament bundle assembly (GO:0051017)2.19285249
158insulin-like growth factor receptor signaling pathway (GO:0048009)2.17452712
159regulation of cholesterol homeostasis (GO:2000188)2.15919263
160regulation of establishment of planar polarity (GO:0090175)2.15005453
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.13219093
162G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.12826841
163axon extension (GO:0048675)2.11060537
164cochlea morphogenesis (GO:0090103)2.09913827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.08042289
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69489905
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60959461
4VDR_21846776_ChIP-Seq_THP-1_Human2.59248507
5GBX2_23144817_ChIP-Seq_PC3_Human2.57108956
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56255158
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50326434
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49873247
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49873247
10DROSHA_22980978_ChIP-Seq_HELA_Human2.38170868
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34910762
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31114411
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30354453
14RACK7_27058665_Chip-Seq_MCF-7_Human2.28959808
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28851981
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25189065
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23050219
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22132131
19* P68_20966046_ChIP-Seq_HELA_Human2.18477760
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16566811
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.09085330
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09036009
23KDM2B_26808549_Chip-Seq_DND41_Human2.07914958
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07855452
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.06704463
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06321339
27* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04592870
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04428374
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.00610223
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.94785587
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.90246885
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.89587818
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89174074
34SMC4_20622854_ChIP-Seq_HELA_Human1.85642719
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.84252367
36* REST_21632747_ChIP-Seq_MESCs_Mouse1.79647267
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.78801931
38CREB1_26743006_Chip-Seq_LNCaP_Human1.76449684
39TCF7_22412390_ChIP-Seq_EML_Mouse1.72650778
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69289695
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.68289218
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.67407662
43MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.67132078
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66955695
45SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63673378
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.63240183
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57469654
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.54671506
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.51694882
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51624726
51MYC_22102868_ChIP-Seq_BL_Human1.51078619
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.49966769
53AR_21572438_ChIP-Seq_LNCaP_Human1.48608410
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47717650
55TP53_22127205_ChIP-Seq_IMR90_Human1.44812797
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42761160
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41884921
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41451098
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40471872
60* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40357749
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39592100
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37256942
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33691150
64KDM2B_26808549_Chip-Seq_K562_Human1.32932914
65* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32317661
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30845337
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.30842801
68AHR_22903824_ChIP-Seq_MCF-7_Human1.28114735
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27058368
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26118728
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24503789
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.24147752
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.23901063
74SMAD4_21799915_ChIP-Seq_A2780_Human1.23898903
75* BCOR_27268052_Chip-Seq_Bcells_Human1.23777906
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.23325986
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23278567
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23028464
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22832022
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.22638042
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.22190062
82E2F1_20622854_ChIP-Seq_HELA_Human1.21585384
83* RARA_24833708_ChIP-Seq_LIVER_Mouse1.20317807
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19629244
85BCL6_27268052_Chip-Seq_Bcells_Human1.19587797
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19585796
87RARB_24833708_ChIP-Seq_LIVER_Mouse1.19070768
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.18972629
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18708827
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17909285
91MAF_26560356_Chip-Seq_TH2_Human1.17891004
92TP53_23651856_ChIP-Seq_MEFs_Mouse1.17687248
93* AR_19668381_ChIP-Seq_PC3_Human1.15057033
94SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14966315
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14962779
96* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14680118
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.14562586
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14362922
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14339000
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14016607
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13633121
102* PHF8_20622854_ChIP-Seq_HELA_Human1.13562045
103* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13397852
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12945849
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.12215192
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.11951371
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11153055
108SA1_27219007_Chip-Seq_Bcells_Human1.10618091
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10458802
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10050598
111* TP63_22573176_ChIP-Seq_HFKS_Human1.09782647
112STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09754178
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.09423563
114OCT4_19829295_ChIP-Seq_ESCs_Human1.09086828
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08627476
116JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08183408
117ZNF274_21170338_ChIP-Seq_K562_Hela1.07910284
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07868227
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05749500
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04451876
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03783991
122CTCF_27219007_Chip-Seq_Bcells_Human1.03633414
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03428220
124RXR_22108803_ChIP-Seq_LS180_Human1.00787607
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.99782221
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98813873
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98196674
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97481911
129STAT3_23295773_ChIP-Seq_U87_Human0.97377056
130ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96675305
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95330695
132AR_25329375_ChIP-Seq_VCAP_Human0.94815078
133* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94516803
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.93422744
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.93011342
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91837569
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91706776
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.91700769
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91528232
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91243383
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87159922
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86961897
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86576631
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85811617
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.85409980
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85051460
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84256047
148* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84129030
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83944599
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83942973
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.83587254
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83212943
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83179829
154* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83073789
155ISL1_27105846_Chip-Seq_CPCs_Mouse0.82315058
156LXR_22292898_ChIP-Seq_THP-1_Human0.81682572
157TRIM28_21343339_ChIP-Seq_HEK293_Human0.81115717
158SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80769935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.41387956
2MP0003705_abnormal_hypodermis_morpholog3.84180339
3MP0005409_darkened_coat_color3.56501006
4MP0004043_abnormal_pH_regulation3.36355955
5MP0005171_absent_coat_pigmentation3.21060196
6MP0003635_abnormal_synaptic_transmissio3.14546635
7MP0004270_analgesia3.06035501
8MP0003880_abnormal_central_pattern2.81592479
9MP0002063_abnormal_learning/memory/cond2.50083956
10MP0009745_abnormal_behavioral_response2.47956484
11MP0005360_urolithiasis2.41071577
12MP0000751_myopathy2.35605886
13MP0002064_seizures2.35483866
14MP0004885_abnormal_endolymph2.34311113
15MP0009046_muscle_twitch2.33319085
16MP0003136_yellow_coat_color2.17594636
17MP0002249_abnormal_larynx_morphology2.13460564
18MP0001986_abnormal_taste_sensitivity2.10154721
19MP0003123_paternal_imprinting2.06544167
20MP0009780_abnormal_chondrocyte_physiolo2.04202112
21MP0002822_catalepsy2.02521077
22MP0004858_abnormal_nervous_system2.01529370
23MP0001348_abnormal_lacrimal_gland1.96553485
24MP0002572_abnormal_emotion/affect_behav1.95200499
25MP0001765_abnormal_ion_homeostasis1.94013346
26MP0001486_abnormal_startle_reflex1.92761675
27MP0004145_abnormal_muscle_electrophysio1.91374060
28MP0005257_abnormal_intraocular_pressure1.88451613
29MP0001188_hyperpigmentation1.82442535
30MP0005423_abnormal_somatic_nervous1.77713540
31MP0002272_abnormal_nervous_system1.75326067
32MP0008961_abnormal_basal_metabolism1.74279660
33MP0005174_abnormal_tail_pigmentation1.73137719
34MP0001968_abnormal_touch/_nociception1.72187790
35MP0002734_abnormal_mechanical_nocicepti1.71025123
36MP0005076_abnormal_cell_differentiation1.69780683
37MP0001440_abnormal_grooming_behavior1.68448640
38MP0005332_abnormal_amino_acid1.64238961
39MP0003878_abnormal_ear_physiology1.64113467
40MP0005377_hearing/vestibular/ear_phenot1.64113467
41MP0004019_abnormal_vitamin_homeostasis1.63153703
42MP0003879_abnormal_hair_cell1.63147902
43MP0003646_muscle_fatigue1.61875561
44MP0003283_abnormal_digestive_organ1.61176303
45MP0000778_abnormal_nervous_system1.58431205
46MP0002067_abnormal_sensory_capabilities1.54180908
47MP0002735_abnormal_chemical_nociception1.51624907
48MP0003329_amyloid_beta_deposits1.50328814
49MP0000003_abnormal_adipose_tissue1.46971001
50MP0008438_abnormal_cutaneous_collagen1.46346123
51MP0003279_aneurysm1.44870674
52MP0003195_calcinosis1.44314907
53MP0000569_abnormal_digit_pigmentation1.42601574
54MP0009384_cardiac_valve_regurgitation1.40617798
55MP0008569_lethality_at_weaning1.39128973
56MP0001958_emphysema1.35679954
57MP0000747_muscle_weakness1.32600887
58MP0000678_abnormal_parathyroid_gland1.32267488
59MP0001849_ear_inflammation1.30556309
60MP0001501_abnormal_sleep_pattern1.28089020
61MP0000750_abnormal_muscle_regeneration1.26595886
62MP0002736_abnormal_nociception_after1.26093337
63MP0000013_abnormal_adipose_tissue1.25969948
64MP0002909_abnormal_adrenal_gland1.25459990
65MP0004811_abnormal_neuron_physiology1.24884368
66MP0002837_dystrophic_cardiac_calcinosis1.24697793
67MP0002557_abnormal_social/conspecific_i1.21726272
68MP0000566_synostosis1.19813692
69MP0002066_abnormal_motor_capabilities/c1.18655178
70MP0003633_abnormal_nervous_system1.18653861
71MP0004924_abnormal_behavior1.13370913
72MP0005386_behavior/neurological_phenoty1.13370913
73MP0002733_abnormal_thermal_nociception1.12289300
74MP0002184_abnormal_innervation1.11696032
75MP0003122_maternal_imprinting1.11450222
76MP0003091_abnormal_cell_migration1.10441872
77MP0001177_atelectasis1.10048129
78MP0004215_abnormal_myocardial_fiber1.09097686
79MP0001756_abnormal_urination1.08359975
80MP0004484_altered_response_of1.07328340
81MP0004742_abnormal_vestibular_system1.07318943
82MP0003942_abnormal_urinary_system1.06888253
83MP0001970_abnormal_pain_threshold1.06436793
84MP0000955_abnormal_spinal_cord1.06394603
85MP0002089_abnormal_postnatal_growth/wei1.06133518
86MP0005535_abnormal_body_temperature1.06087193
87MP0005330_cardiomyopathy1.05473452
88MP0010030_abnormal_orbit_morphology1.04142322
89MP0004233_abnormal_muscle_weight1.03585049
90MP0005167_abnormal_blood-brain_barrier1.02875168
91MP0005058_abnormal_lysosome_morphology1.02102170
92MP0003453_abnormal_keratinocyte_physiol1.01143885
93MP0002882_abnormal_neuron_morphology1.00621172
94MP0009643_abnormal_urine_homeostasis0.99808277
95MP0005620_abnormal_muscle_contractility0.99433168
96MP0000538_abnormal_urinary_bladder0.98974186
97MP0003172_abnormal_lysosome_physiology0.97312659
98MP0004130_abnormal_muscle_cell0.96494917
99MP0001346_abnormal_lacrimal_gland0.96368993
100MP0000749_muscle_degeneration0.95888499
101MP0001485_abnormal_pinna_reflex0.95377666
102MP0005623_abnormal_meninges_morphology0.95265688
103MP0002138_abnormal_hepatobiliary_system0.94402648
104MP0004036_abnormal_muscle_relaxation0.94178733
105MP0002234_abnormal_pharynx_morphology0.93769917
106MP0004272_abnormal_basement_membrane0.93403342
107MP0001661_extended_life_span0.92232266
108MP0003631_nervous_system_phenotype0.92192864
109MP0000759_abnormal_skeletal_muscle0.92075296
110MP0002069_abnormal_eating/drinking_beha0.91819466
111MP0005375_adipose_tissue_phenotype0.90960400
112MP0003634_abnormal_glial_cell0.89827416
113MP0000534_abnormal_ureter_morphology0.89582699
114MP0003137_abnormal_impulse_conducting0.89258228
115MP0010386_abnormal_urinary_bladder0.87771061
116MP0002139_abnormal_hepatobiliary_system0.87579294
117MP0005636_abnormal_mineral_homeostasis0.86485284
118MP0004085_abnormal_heartbeat0.86387613
119MP0002152_abnormal_brain_morphology0.84999665
120MP0004087_abnormal_muscle_fiber0.84446432
121MP0004185_abnormal_adipocyte_glucose0.83178809
122MP0003075_altered_response_to0.83108746
123MP0001502_abnormal_circadian_rhythm0.82221039
124MP0005503_abnormal_tendon_morphology0.82195694
125MP0005083_abnormal_biliary_tract0.80295591
126MP0002136_abnormal_kidney_physiology0.79699514
127MP0001963_abnormal_hearing_physiology0.79325797
128MP0010368_abnormal_lymphatic_system0.79320448
129MP0000733_abnormal_muscle_development0.78569090
130MP0008874_decreased_physiological_sensi0.76580681
131MP0003690_abnormal_glial_cell0.76357007
132MP0000767_abnormal_smooth_muscle0.76118114
133MP0005646_abnormal_pituitary_gland0.75698021
134MP0002896_abnormal_bone_mineralization0.75585312
135MP0003385_abnormal_body_wall0.75302600
136MP0009840_abnormal_foam_cell0.74892670
137MP0002269_muscular_atrophy0.74586129
138MP0003115_abnormal_respiratory_system0.74581534
139MP0005369_muscle_phenotype0.74438756
140MP0002160_abnormal_reproductive_system0.74412397
141MP0002106_abnormal_muscle_physiology0.73896404
142MP0005666_abnormal_adipose_tissue0.72400917
143MP0010630_abnormal_cardiac_muscle0.72244555
144MP0002108_abnormal_muscle_morphology0.71785201
145MP0001664_abnormal_digestion0.71742365
146MP0000920_abnormal_myelination0.71549277
147MP0002229_neurodegeneration0.70830550
148MP0000230_abnormal_systemic_arterial0.70238763
149MP0002932_abnormal_joint_morphology0.70163542
150MP0002638_abnormal_pupillary_reflex0.69782607
151MP0001299_abnormal_eye_distance/0.68889720
152MP0002116_abnormal_craniofacial_bone0.65647681
153MP0000462_abnormal_digestive_system0.64639083

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)5.81592181
2Metabolic alkalosis (HP:0200114)4.98750476
3Ulnar bowing (HP:0003031)4.74345739
4Gout (HP:0001997)4.67474452
5Turricephaly (HP:0000262)4.66831625
6Hypokalemic alkalosis (HP:0001949)4.61185566
7Hyperactive renin-angiotensin system (HP:0000841)4.38493197
8Focal motor seizures (HP:0011153)4.22612252
9Polyuria (HP:0000103)4.20762668
10Hypomagnesemia (HP:0002917)4.19963503
11Annular pancreas (HP:0001734)4.16086762
12Thin bony cortex (HP:0002753)4.14538271
13Abnormal urine output (HP:0012590)4.01208710
14Myokymia (HP:0002411)4.00556985
15Abnormality of chloride homeostasis (HP:0011422)3.83552995
16Abnormality of renal excretion (HP:0011036)3.81318374
17Polydipsia (HP:0001959)3.76558967
18Abnormal drinking behavior (HP:0030082)3.76558967
19Akinesia (HP:0002304)3.67284645
20Testicular atrophy (HP:0000029)3.60353976
21Protrusio acetabuli (HP:0003179)3.52903205
22Coronal craniosynostosis (HP:0004440)3.51745296
23Abnormality of magnesium homeostasis (HP:0004921)3.51296184
24Rib fusion (HP:0000902)3.46551907
25Abnormality of renin-angiotensin system (HP:0000847)3.29229724
26Focal seizures (HP:0007359)3.23227979
27Hemorrhage of the eye (HP:0011885)3.21615911
28Hyperaldosteronism (HP:0000859)3.17416195
29Hyperuricemia (HP:0002149)3.13011899
30Increased purine levels (HP:0004368)3.13011899
31Hypercalciuria (HP:0002150)3.01047589
32Thin ribs (HP:0000883)2.96210231
33Shallow orbits (HP:0000586)2.88909896
34Tetany (HP:0001281)2.85528272
35Visual hallucinations (HP:0002367)2.83372264
36Hyperacusis (HP:0010780)2.80194929
37Myopathic facies (HP:0002058)2.79176932
38Cerebral aneurysm (HP:0004944)2.78209973
39Hyperventilation (HP:0002883)2.74111472
40Renal salt wasting (HP:0000127)2.72108880
41Intestinal fistula (HP:0100819)2.70169591
42Hypokalemia (HP:0002900)2.66019542
43Bowed forearm bones (HP:0003956)2.64678790
44Bowing of the arm (HP:0006488)2.64678790
45Mesangial abnormality (HP:0001966)2.62363231
46Alkalosis (HP:0001948)2.62229991
47Action tremor (HP:0002345)2.60178632
48Vaginal fistula (HP:0004320)2.58415887
49Abnormality of potassium homeostasis (HP:0011042)2.58192554
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56752785
51Exercise-induced myalgia (HP:0003738)2.56092504
52Proximal tubulopathy (HP:0000114)2.52265764
53Abnormal eating behavior (HP:0100738)2.51864133
54Popliteal pterygium (HP:0009756)2.50344080
55Abnormal social behavior (HP:0012433)2.47071316
56Impaired social interactions (HP:0000735)2.47071316
57Broad-based gait (HP:0002136)2.45085393
58Atrioventricular block (HP:0001678)2.42628630
59Postural instability (HP:0002172)2.39209184
60Ketoacidosis (HP:0001993)2.38604368
61Poor eye contact (HP:0000817)2.37559746
62Choanal stenosis (HP:0000452)2.37325254
63Joint hemorrhage (HP:0005261)2.36422870
64Rectal fistula (HP:0100590)2.34677357
65Rectovaginal fistula (HP:0000143)2.34677357
66Broad metatarsal (HP:0001783)2.33118165
67Ankle clonus (HP:0011448)2.32783198
68Myotonia (HP:0002486)2.30271152
69Progressive cerebellar ataxia (HP:0002073)2.29140506
70Dysmetric saccades (HP:0000641)2.28771799
71Epileptic encephalopathy (HP:0200134)2.28401500
72Abnormality of purine metabolism (HP:0004352)2.27778652
73Abnormality of the lower motor neuron (HP:0002366)2.27523695
74Facial hemangioma (HP:0000329)2.26537379
75Aplasia of the musculature (HP:0100854)2.25574763
76Bronchomalacia (HP:0002780)2.24599979
77Generalized tonic-clonic seizures (HP:0002069)2.24235817
78Hyperglycinuria (HP:0003108)2.22223017
79Arterial tortuosity (HP:0005116)2.19920765
80Joint stiffness (HP:0001387)2.19281883
81Supranuclear gaze palsy (HP:0000605)2.16491300
82Vascular tortuosity (HP:0004948)2.15391106
83Bladder diverticulum (HP:0000015)2.14133338
84Abnormality of the intrinsic pathway (HP:0010989)2.12048958
85Mask-like facies (HP:0000298)2.11994853
86Cervical subluxation (HP:0003308)2.11878569
87Fetal akinesia sequence (HP:0001989)2.11604334
88Dysdiadochokinesis (HP:0002075)2.11566671
89Febrile seizures (HP:0002373)2.11461632
90Urinary urgency (HP:0000012)2.10686275
91Lymphangioma (HP:0100764)2.10185177
92Mitral regurgitation (HP:0001653)2.08316529
93Atonic seizures (HP:0010819)2.07691686
94Insomnia (HP:0100785)2.07681423
95Hyperkalemia (HP:0002153)2.06756295
96Pointed chin (HP:0000307)2.06159879
97Poikiloderma (HP:0001029)2.05798292
98Premature rupture of membranes (HP:0001788)2.04292158
99Absence seizures (HP:0002121)2.04175123
100Anxiety (HP:0000739)2.01761310
101Exercise-induced muscle cramps (HP:0003710)2.01610787
102Anteriorly placed anus (HP:0001545)2.01605524
103Narrow nasal bridge (HP:0000446)2.01412664
104Bundle branch block (HP:0011710)1.99973001
105Confusion (HP:0001289)1.99727225
106Adrenal overactivity (HP:0002717)1.98684217
107Urinary bladder sphincter dysfunction (HP:0002839)1.98315792
108Pterygium (HP:0001059)1.98177607
109Ventricular fibrillation (HP:0001663)1.98150310
110Depression (HP:0000716)1.97846040
111Abnormal atrioventricular conduction (HP:0005150)1.97783146
112Genu recurvatum (HP:0002816)1.97600573
113Hip contracture (HP:0003273)1.97405269
114Impaired vibration sensation in the lower limbs (HP:0002166)1.97396664
115Neonatal onset (HP:0003623)1.96647284
116Gaze-evoked nystagmus (HP:0000640)1.96070620
117Neurofibrillary tangles (HP:0002185)1.95953280
118Nephrocalcinosis (HP:0000121)1.95324037
119Muscle fiber splitting (HP:0003555)1.94436936
120Difficulty running (HP:0009046)1.93882242
121Stridor (HP:0010307)1.91765440
122Heart block (HP:0012722)1.91745392
123Muscle hypertrophy of the lower extremities (HP:0008968)1.91224305
124Elfin facies (HP:0004428)1.90417614
125Prolonged partial thromboplastin time (HP:0003645)1.90024074
126Abnormality of the calf musculature (HP:0001430)1.87755297
127Mildly elevated creatine phosphokinase (HP:0008180)1.87692412
128Broad face (HP:0000283)1.86317954
129Obstructive sleep apnea (HP:0002870)1.86289615
130Abnormality of the aortic arch (HP:0012303)1.86009015
131Calf muscle hypertrophy (HP:0008981)1.85034135
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84794407
133Dysmetria (HP:0001310)1.84237494
134Renal tubular acidosis (HP:0001947)1.83691369
135Rectal prolapse (HP:0002035)1.83387757
136Abnormality of proline metabolism (HP:0010907)1.83227366
137Hydroxyprolinuria (HP:0003080)1.83227366
138Hypoventilation (HP:0002791)1.82759817
139Intention tremor (HP:0002080)1.82516419
140Neonatal short-limb short stature (HP:0008921)1.81531353
141Sudden death (HP:0001699)1.81365353
142Dialeptic seizures (HP:0011146)1.80077621
143Increased variability in muscle fiber diameter (HP:0003557)1.77877448
144Supernumerary nipples (HP:0002558)1.76780914
145Abnormality of glycine metabolism (HP:0010895)1.76669642
146Abnormality of serine family amino acid metabolism (HP:0010894)1.76669642
147Genetic anticipation (HP:0003743)1.76580153
148Nephrolithiasis (HP:0000787)1.76071726
149Ketosis (HP:0001946)1.75233143
150Distal upper limb amyotrophy (HP:0007149)1.74916555
151Upper limb amyotrophy (HP:0009129)1.74916555
152Hemiplegia (HP:0002301)1.74887229
153Deep venous thrombosis (HP:0002625)1.74565123
154Biconcave vertebral bodies (HP:0004586)1.74556319
155Renal duplication (HP:0000075)1.73174101
156Vertebral clefting (HP:0008428)1.72712348
157Congenital hip dislocation (HP:0001374)1.72332105
158Prolonged QT interval (HP:0001657)1.72077388
159Status epilepticus (HP:0002133)1.71551138
160Disproportionate tall stature (HP:0001519)1.71068796
161Atelectasis (HP:0100750)1.70868760
162Germ cell neoplasia (HP:0100728)1.70766667
163Easy fatigability (HP:0003388)1.70168779
164Aortic aneurysm (HP:0004942)1.67972534
165Aplasia involving bones of the upper limbs (HP:0009823)1.67794486
166Aplasia of the phalanges of the hand (HP:0009802)1.67794486
167Aplasia involving bones of the extremities (HP:0009825)1.67794486
168Spina bifida occulta (HP:0003298)1.67715400
169Scanning speech (HP:0002168)1.66971005
170Tibial bowing (HP:0002982)1.66404388
171Hand muscle atrophy (HP:0009130)1.65663319
172Long palpebral fissure (HP:0000637)1.64648293
173Lower limb asymmetry (HP:0100559)1.64530807
174Dislocated radial head (HP:0003083)1.64341663
175Delayed epiphyseal ossification (HP:0002663)1.63840352
176Cerebral inclusion bodies (HP:0100314)1.62023131
177Widely patent fontanelles and sutures (HP:0004492)1.61569874
178Polyphagia (HP:0002591)1.61371607
179Type 1 muscle fiber predominance (HP:0003803)1.61236581
180Asymmetry of the thorax (HP:0001555)1.60096804
181Rapidly progressive (HP:0003678)1.60007775
182Achilles tendon contracture (HP:0001771)1.59992126
183Partial duplication of thumb phalanx (HP:0009944)1.59159037
184Round ear (HP:0100830)1.58665711
185Ulnar deviation of the wrist (HP:0003049)1.58524949
186Bowel diverticulosis (HP:0005222)1.57977534
187Abnormality of the radial head (HP:0003995)1.57775251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.92020255
2EPHA43.52048647
3MAPK153.45389883
4NTRK33.38080590
5WNK33.37145772
6OXSR13.37004011
7SIK12.60830130
8EEF2K2.36400831
9MAP3K42.25363887
10MARK12.20421085
11MAP3K92.17671838
12DAPK22.15403140
13PRKD32.06580281
14STK382.05876690
15STK391.99300674
16PAK61.87079058
17MINK11.82746592
18FGFR41.75418587
19ERN11.74032136
20SMG11.73694788
21PKN21.72350689
22WNK11.66188500
23MAP2K41.64579402
24PINK11.53898657
25NTRK11.50665197
26SGK2231.49116003
27SGK4941.49116003
28CDK121.48175691
29PHKG11.47612548
30PHKG21.47612548
31KSR21.44088422
32TYRO31.42638143
33CAMKK11.39567111
34NTRK21.38011478
35RPS6KA21.33890816
36MAP3K71.23459596
37RIPK11.21832615
38ARAF1.21668082
39DDR21.21643188
40RIPK41.20244928
41CDK51.13272183
42SGK31.11132282
43MAP2K71.10730887
44TRIB31.10522753
45MTOR1.10331549
46KSR11.08037587
47SIK21.07925130
48SGK21.04597133
49PTK2B1.02871352
50PDK31.02643065
51PDK41.02643065
52LATS21.02453773
53TAOK11.00004530
54PAK30.96857618
55STK110.96691352
56PRKCH0.95276996
57DYRK1B0.94935906
58NEK10.94398993
59DAPK10.93261992
60SGK10.93121588
61DMPK0.92797525
62EPHB20.90013362
63ICK0.89190384
64PRPF4B0.88813132
65MARK20.88092219
66CDK11A0.87752012
67MAP3K100.86056413
68CAMK1G0.85781914
69MAP3K120.85230700
70MAP3K20.83729642
71LMTK20.83429919
72PRKCG0.82126886
73TTN0.79109325
74PNCK0.78910915
75PDGFRA0.78798387
76RPS6KC10.78128600
77RPS6KL10.78128600
78OBSCN0.75493526
79MAP2K30.74730543
80TNIK0.71245332
81GRK50.69235931
82UHMK10.67064460
83BMX0.66921831
84BRAF0.66328243
85FGFR20.66195965
86PDK20.64296427
87PTK20.64077386
88RPS6KA60.63519388
89CAMK10.63494446
90CAMK2A0.63478409
91CDK140.62493668
92FER0.61918978
93RET0.61351082
94PLK20.60552143
95PRKD20.60102453
96PRKD10.58727040
97CAMK40.58049492
98CAMK1D0.57971994
99STK38L0.57498704
100HIPK20.56797837
101MAP3K110.56581186
102CDC42BPA0.56281921
103MAPK130.55760796
104PDPK10.54929887
105NEK60.54881338
106MAP2K20.53278854
107MAPK110.53058324
108PRKAA10.51875133
109FGFR30.51567506
110MAPK100.50911013
111MUSK0.50603137
112ROCK10.50530187
113CAMKK20.50067027
114MAPK80.49742260
115RPS6KA30.49313739
116PRKCZ0.49179100
117PDK10.48717265
118CAMK2B0.47669146
119NME10.47564995
120MAP3K10.46966766
121ALK0.46951979
122FES0.46554891
123PDGFRB0.44844774
124INSRR0.43900780
125PTK60.43328183
126EPHA20.43176901
127IRAK20.42763406
128ERBB20.42466601
129MAPK120.39839931
130MAP2K10.39048392
131DAPK30.38530363
132PAK20.38051375
133CAMK2G0.37477531
134MAP3K130.37148610
135AKT20.36824025
136CDK150.36362355
137ROCK20.36059501
138CASK0.35886166
139CDK180.35620913
140FYN0.33662626

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.71567191
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56740647
3Synaptic vesicle cycle_Homo sapiens_hsa047212.25121269
4Nicotine addiction_Homo sapiens_hsa050332.20619027
5Sulfur relay system_Homo sapiens_hsa041222.16425248
6Gastric acid secretion_Homo sapiens_hsa049711.88951109
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81811504
8Butanoate metabolism_Homo sapiens_hsa006501.76849406
9Circadian entrainment_Homo sapiens_hsa047131.75654141
10Glutamatergic synapse_Homo sapiens_hsa047241.74737198
11Long-term potentiation_Homo sapiens_hsa047201.73648031
12GABAergic synapse_Homo sapiens_hsa047271.73294568
13Olfactory transduction_Homo sapiens_hsa047401.67275328
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.64953899
15Salivary secretion_Homo sapiens_hsa049701.62935213
16Nitrogen metabolism_Homo sapiens_hsa009101.62181398
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58627261
18Collecting duct acid secretion_Homo sapiens_hsa049661.56648908
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56485936
20Notch signaling pathway_Homo sapiens_hsa043301.54806546
21Amphetamine addiction_Homo sapiens_hsa050311.50984881
22Morphine addiction_Homo sapiens_hsa050321.48468879
23Insulin secretion_Homo sapiens_hsa049111.47942302
24Fructose and mannose metabolism_Homo sapiens_hsa000511.47383799
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46072589
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45659698
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42500836
28Bile secretion_Homo sapiens_hsa049761.38251248
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33028258
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.31026029
31Dopaminergic synapse_Homo sapiens_hsa047281.28827064
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27989069
33mTOR signaling pathway_Homo sapiens_hsa041501.24468073
34Oxytocin signaling pathway_Homo sapiens_hsa049211.23206812
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22632647
36Cholinergic synapse_Homo sapiens_hsa047251.22317751
37Renin secretion_Homo sapiens_hsa049241.21206770
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18437157
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17514449
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16546381
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.15364482
42Taste transduction_Homo sapiens_hsa047421.13720486
43Calcium signaling pathway_Homo sapiens_hsa040201.11188328
44Prion diseases_Homo sapiens_hsa050201.10493671
45Propanoate metabolism_Homo sapiens_hsa006401.08329531
46GnRH signaling pathway_Homo sapiens_hsa049121.06811582
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05111518
48ECM-receptor interaction_Homo sapiens_hsa045121.04569201
49Long-term depression_Homo sapiens_hsa047301.04130057
50Cocaine addiction_Homo sapiens_hsa050301.02759396
51Other glycan degradation_Homo sapiens_hsa005111.01989993
52Protein digestion and absorption_Homo sapiens_hsa049741.01348897
53Hippo signaling pathway_Homo sapiens_hsa043901.00858946
54Dilated cardiomyopathy_Homo sapiens_hsa054141.00847606
55Type II diabetes mellitus_Homo sapiens_hsa049301.00829109
56Mineral absorption_Homo sapiens_hsa049781.00754122
57Cardiac muscle contraction_Homo sapiens_hsa042600.98824639
58Focal adhesion_Homo sapiens_hsa045100.98272196
59AMPK signaling pathway_Homo sapiens_hsa041520.96474260
60cAMP signaling pathway_Homo sapiens_hsa040240.95616211
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95466222
62Axon guidance_Homo sapiens_hsa043600.93089786
63Thyroid hormone synthesis_Homo sapiens_hsa049180.92953987
64Gap junction_Homo sapiens_hsa045400.92904120
65Basal cell carcinoma_Homo sapiens_hsa052170.91253642
66Glioma_Homo sapiens_hsa052140.89453825
67Bladder cancer_Homo sapiens_hsa052190.89427883
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89005554
69Non-small cell lung cancer_Homo sapiens_hsa052230.88499340
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88180001
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87595784
72Serotonergic synapse_Homo sapiens_hsa047260.87514181
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.87023700
74Chronic myeloid leukemia_Homo sapiens_hsa052200.86828347
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85759201
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84013331
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83217674
78Arginine biosynthesis_Homo sapiens_hsa002200.82868950
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78496543
80Choline metabolism in cancer_Homo sapiens_hsa052310.78303464
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77869135
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76173114
83Sphingolipid metabolism_Homo sapiens_hsa006000.75456416
84Melanogenesis_Homo sapiens_hsa049160.74315039
85ErbB signaling pathway_Homo sapiens_hsa040120.74208563
86Lysine degradation_Homo sapiens_hsa003100.73566594
87Pancreatic secretion_Homo sapiens_hsa049720.73164408
88Estrogen signaling pathway_Homo sapiens_hsa049150.72125746
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71773804
90Pyruvate metabolism_Homo sapiens_hsa006200.71763806
91Insulin resistance_Homo sapiens_hsa049310.71620528
92Dorso-ventral axis formation_Homo sapiens_hsa043200.70839612
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70510835
94Ovarian steroidogenesis_Homo sapiens_hsa049130.70285247
95Renal cell carcinoma_Homo sapiens_hsa052110.69359740
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.68675534
97Vitamin digestion and absorption_Homo sapiens_hsa049770.67819895
98Glucagon signaling pathway_Homo sapiens_hsa049220.66345941
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.66211062
100Fatty acid metabolism_Homo sapiens_hsa012120.63580210
101Proteoglycans in cancer_Homo sapiens_hsa052050.63024129
102Circadian rhythm_Homo sapiens_hsa047100.62309848
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.62065423
104Arginine and proline metabolism_Homo sapiens_hsa003300.61913781
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60811026
106* Endocytosis_Homo sapiens_hsa041440.60611516
107Fatty acid degradation_Homo sapiens_hsa000710.60549466
108Vitamin B6 metabolism_Homo sapiens_hsa007500.59364549
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59277787
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58507971
111Wnt signaling pathway_Homo sapiens_hsa043100.57253362
112Tryptophan metabolism_Homo sapiens_hsa003800.54833870
113Inositol phosphate metabolism_Homo sapiens_hsa005620.54210104
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53991040
115Rap1 signaling pathway_Homo sapiens_hsa040150.51617923
116Glycerolipid metabolism_Homo sapiens_hsa005610.51614075
117Histidine metabolism_Homo sapiens_hsa003400.51037629
118Tight junction_Homo sapiens_hsa045300.50101103
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50058572
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49325482
121beta-Alanine metabolism_Homo sapiens_hsa004100.49221527
122Endometrial cancer_Homo sapiens_hsa052130.49106104
123MAPK signaling pathway_Homo sapiens_hsa040100.47082047
124Vibrio cholerae infection_Homo sapiens_hsa051100.45895515
125Peroxisome_Homo sapiens_hsa041460.45060728
126VEGF signaling pathway_Homo sapiens_hsa043700.44809541
127Starch and sucrose metabolism_Homo sapiens_hsa005000.44552975
128PPAR signaling pathway_Homo sapiens_hsa033200.43642550
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43126042
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43025730
131Insulin signaling pathway_Homo sapiens_hsa049100.42326727
132Hedgehog signaling pathway_Homo sapiens_hsa043400.42069834
133Carbon metabolism_Homo sapiens_hsa012000.40990431

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