RAB11FIP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.24689191
2synaptic vesicle maturation (GO:0016188)6.22296635
3locomotory exploration behavior (GO:0035641)6.07442205
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78834637
5synaptic vesicle exocytosis (GO:0016079)5.50607250
6vocalization behavior (GO:0071625)5.47696849
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45649771
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.38884101
9glutamate secretion (GO:0014047)5.33864455
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.25858144
11regulation of synaptic vesicle exocytosis (GO:2000300)5.12395549
12regulation of glutamate receptor signaling pathway (GO:1900449)4.91664622
13layer formation in cerebral cortex (GO:0021819)4.72639581
14regulation of neuronal synaptic plasticity (GO:0048168)4.62201369
15neurotransmitter secretion (GO:0007269)4.57605827
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55149835
17protein localization to synapse (GO:0035418)4.52084902
18exploration behavior (GO:0035640)4.52004013
19regulation of synaptic vesicle transport (GO:1902803)4.49589512
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.43361884
21regulation of synapse structural plasticity (GO:0051823)4.27984218
22amino acid import (GO:0043090)4.24655585
23gamma-aminobutyric acid transport (GO:0015812)4.21585509
24dendritic spine morphogenesis (GO:0060997)4.21014342
25neuron cell-cell adhesion (GO:0007158)4.20602097
26neurotransmitter-gated ion channel clustering (GO:0072578)4.16496811
27neuronal action potential propagation (GO:0019227)4.14884336
28neuromuscular process controlling balance (GO:0050885)4.10162136
29synaptic transmission, glutamatergic (GO:0035249)4.04522890
30negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.98277752
31synaptic vesicle endocytosis (GO:0048488)3.95813003
32proline transport (GO:0015824)3.94815387
33cellular potassium ion homeostasis (GO:0030007)3.93473114
34long-term memory (GO:0007616)3.89682553
35glutamate receptor signaling pathway (GO:0007215)3.88714299
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87829928
37positive regulation of synapse maturation (GO:0090129)3.87721051
38central nervous system myelination (GO:0022010)3.84099622
39axon ensheathment in central nervous system (GO:0032291)3.84099622
40sodium ion export (GO:0071436)3.83154159
41neuron-neuron synaptic transmission (GO:0007270)3.80916229
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79386656
43positive regulation of membrane potential (GO:0045838)3.75994388
44regulation of dendritic spine morphogenesis (GO:0061001)3.75271810
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74802876
46regulation of voltage-gated calcium channel activity (GO:1901385)3.68898552
47neuromuscular process controlling posture (GO:0050884)3.67370931
48regulation of synaptic plasticity (GO:0048167)3.65784840
49neurotransmitter transport (GO:0006836)3.60663998
50regulation of postsynaptic membrane potential (GO:0060078)3.59667673
51cell migration in hindbrain (GO:0021535)3.59431365
52negative regulation of dendrite morphogenesis (GO:0050774)3.58851543
53activation of protein kinase A activity (GO:0034199)3.58489410
54auditory behavior (GO:0031223)3.55696768
55positive regulation of Rap GTPase activity (GO:0032854)3.53557751
56cerebellar Purkinje cell differentiation (GO:0021702)3.52533013
57regulation of synapse maturation (GO:0090128)3.51981870
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.49055274
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.46792426
60potassium ion import (GO:0010107)3.46203725
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43277248
62glycine transport (GO:0015816)3.42752257
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.40206933
64regulation of neurotransmitter secretion (GO:0046928)3.37799039
65positive regulation of dendritic spine morphogenesis (GO:0061003)3.37026347
66neuromuscular process (GO:0050905)3.35598023
67regulation of neurotransmitter levels (GO:0001505)3.33913655
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33310859
69dendrite morphogenesis (GO:0048813)3.32143218
70potassium ion homeostasis (GO:0055075)3.31832240
71response to auditory stimulus (GO:0010996)3.30316491
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28165439
73prepulse inhibition (GO:0060134)3.27096389
74neuron recognition (GO:0008038)3.26654434
75long-term synaptic potentiation (GO:0060291)3.26429285
76transmission of nerve impulse (GO:0019226)3.25449260
77regulation of Rap GTPase activity (GO:0032317)3.22696278
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.17807562
79axonal fasciculation (GO:0007413)3.15172555
80positive regulation of dendritic spine development (GO:0060999)3.14777039
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14382227
82cerebellar granule cell differentiation (GO:0021707)3.13857378
83positive regulation of neurotransmitter transport (GO:0051590)3.13327306
84cellular sodium ion homeostasis (GO:0006883)3.13100907
85cell differentiation in hindbrain (GO:0021533)3.12758781
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.12120202
87regulation of exocytosis (GO:0017157)3.11446725
88regulation of neurotransmitter transport (GO:0051588)3.11378659
89peptidyl-tyrosine autophosphorylation (GO:0038083)3.09786378
90positive regulation of neurotransmitter secretion (GO:0001956)3.09216973
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09130517
92postsynaptic membrane organization (GO:0001941)3.09039537
93regulation of dendritic spine development (GO:0060998)3.06373815
94L-amino acid import (GO:0043092)3.05256860
95dendritic spine organization (GO:0097061)3.03987594
96cell communication by electrical coupling (GO:0010644)3.03098361
97signal complex assembly (GO:0007172)3.02671306
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02477169
99vesicle transport along microtubule (GO:0047496)3.01690864
100learning (GO:0007612)3.01614802
101adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.00208329
102membrane hyperpolarization (GO:0060081)3.00171421
103membrane depolarization (GO:0051899)2.99130924
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.98290753
105neuronal ion channel clustering (GO:0045161)2.97724833
106regulation of clathrin-mediated endocytosis (GO:2000369)2.97153288
107regulation of vesicle fusion (GO:0031338)2.95993857
108regulation of cAMP-dependent protein kinase activity (GO:2000479)2.95879430
109regulation of ARF protein signal transduction (GO:0032012)2.95768287
110regulation of synaptic transmission (GO:0050804)2.93542337
111positive regulation of synaptic transmission (GO:0050806)2.92320762
112response to histamine (GO:0034776)2.91102952
113regulation of respiratory system process (GO:0044065)2.90895037
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90611225
115membrane depolarization during action potential (GO:0086010)2.89782230
116mechanosensory behavior (GO:0007638)2.88410498
117innervation (GO:0060384)2.87919982
118establishment of nucleus localization (GO:0040023)2.87244757
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86795321
120acidic amino acid transport (GO:0015800)2.82070830
121negative regulation of cell killing (GO:0031342)2.81951999
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81951999
123neurotransmitter uptake (GO:0001504)2.80810113
124positive regulation of exocytosis (GO:0045921)2.79934262
125establishment of synaptic vesicle localization (GO:0097480)2.78134922
126synaptic vesicle transport (GO:0048489)2.78134922
127synaptic transmission (GO:0007268)2.76595970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38517424
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.04755760
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.91022513
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.90465486
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79771809
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71776633
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71468309
8DROSHA_22980978_ChIP-Seq_HELA_Human2.70057335
9GBX2_23144817_ChIP-Seq_PC3_Human2.62224488
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53179936
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53179936
12* REST_18959480_ChIP-ChIP_MESCs_Mouse2.46802286
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40517809
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33758055
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32733458
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32513732
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22835403
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.21745363
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19137522
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.19037193
21* ERG_21242973_ChIP-ChIP_JURKAT_Human2.18120455
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14544764
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14459512
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09796293
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05600162
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04184924
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.03446380
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01409583
29AR_21572438_ChIP-Seq_LNCaP_Human1.88948890
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.82589348
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80024625
32* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.77783527
33KDM2B_26808549_Chip-Seq_K562_Human1.69750620
34* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64748172
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58871838
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57505906
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55698473
38* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49822715
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.47606379
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.44067669
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44021690
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43926618
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.42715154
44* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36293798
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35609770
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32715522
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30003130
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28680612
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26972691
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26222765
51AR_19668381_ChIP-Seq_PC3_Human1.25332205
52TCF7_22412390_ChIP-Seq_EML_Mouse1.22770449
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21818148
54SMAD4_21799915_ChIP-Seq_A2780_Human1.21734981
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19753300
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18372866
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.18066311
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.16937438
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16007950
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15302590
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12806882
62P68_20966046_ChIP-Seq_HELA_Human1.12763192
63CTCF_27219007_Chip-Seq_Bcells_Human1.10334185
64* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09975353
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09592714
66* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07641706
67DPY_21335234_ChIP-Seq_ESCs_Mouse1.06248572
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.05713082
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04420320
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03964584
71ZNF274_21170338_ChIP-Seq_K562_Hela1.03957165
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03727782
73LXR_22292898_ChIP-Seq_THP-1_Human1.03490155
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01934433
75STAT3_23295773_ChIP-Seq_U87_Human1.00872100
76* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98510392
77KDM2B_26808549_Chip-Seq_JURKAT_Human0.96279061
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96111220
79* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95944252
80KDM2B_26808549_Chip-Seq_DND41_Human0.95787612
81AHR_22903824_ChIP-Seq_MCF-7_Human0.94877086
82RNF2_27304074_Chip-Seq_NSC_Mouse0.94492497
83* GATA1_19941827_ChIP-Seq_MEL_Mouse0.93420458
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93203596
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92869187
86* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92030489
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92015042
88SMC4_20622854_ChIP-Seq_HELA_Human0.91807964
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.91189835
90SMAD3_21741376_ChIP-Seq_EPCs_Human0.91088897
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.90545758
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90377421
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.90286114
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89575610
95* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89482134
96OCT4_19829295_ChIP-Seq_ESCs_Human0.89344292
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89031588
98* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88791816
99AR_25329375_ChIP-Seq_VCAP_Human0.88399869
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87695654
101SA1_27219007_Chip-Seq_Bcells_Human0.87265033
102* TCF4_23295773_ChIP-Seq_U87_Human0.87125969
103RUNX_20019798_ChIP-Seq_JUKART_Human0.87046457
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.87009656
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86779943
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86779943
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86375900
108KLF4_19829295_ChIP-Seq_ESCs_Human0.85792768
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85042165
110* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84199477
111TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83641673
112* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83380509
113FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81745715
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81675901
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81604578
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.80802411
117CREB1_26743006_Chip-Seq_LNCaP_Human0.80610281
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80356660
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80007049
120SMAD4_21741376_ChIP-Seq_ESCs_Human0.79779040
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.79685649
122SA1_27219007_Chip-Seq_ERYTHROID_Human0.78648225
123RXR_22108803_ChIP-Seq_LS180_Human0.78049318
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77236485
125POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75470859
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.74802241
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74555300
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71800015
129JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71594399
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.71391808
131* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.71248297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.95166760
2MP0003880_abnormal_central_pattern4.45295032
3MP0003635_abnormal_synaptic_transmissio4.25193718
4MP0004270_analgesia3.75286264
5MP0002063_abnormal_learning/memory/cond3.51826239
6MP0009745_abnormal_behavioral_response3.33088118
7MP0009046_muscle_twitch3.32879835
8MP0002064_seizures3.22311896
9MP0002822_catalepsy3.04148981
10MP0002572_abnormal_emotion/affect_behav2.88768763
11MP0005423_abnormal_somatic_nervous2.82276722
12MP0001968_abnormal_touch/_nociception2.69472001
13MP0002734_abnormal_mechanical_nocicepti2.52477429
14MP0001486_abnormal_startle_reflex2.52031019
15MP0002272_abnormal_nervous_system2.45899773
16MP0008569_lethality_at_weaning2.09369858
17MP0002733_abnormal_thermal_nociception2.08632897
18MP0001970_abnormal_pain_threshold2.00770552
19MP0001440_abnormal_grooming_behavior1.99493190
20MP0009780_abnormal_chondrocyte_physiolo1.99003102
21MP0000778_abnormal_nervous_system1.98816557
22MP0004811_abnormal_neuron_physiology1.96994771
23MP0001501_abnormal_sleep_pattern1.96148632
24MP0004858_abnormal_nervous_system1.93334672
25MP0002736_abnormal_nociception_after1.90563847
26MP0002067_abnormal_sensory_capabilities1.87824617
27MP0002735_abnormal_chemical_nociception1.84377250
28MP0002184_abnormal_innervation1.81034089
29MP0004885_abnormal_endolymph1.79088947
30MP0003329_amyloid_beta_deposits1.79065956
31MP0000955_abnormal_spinal_cord1.76669783
32MP0003123_paternal_imprinting1.75920648
33MP0005386_behavior/neurological_phenoty1.72359599
34MP0004924_abnormal_behavior1.72359599
35MP0002557_abnormal_social/conspecific_i1.71755819
36MP0005377_hearing/vestibular/ear_phenot1.70351801
37MP0003878_abnormal_ear_physiology1.70351801
38MP0002909_abnormal_adrenal_gland1.63528018
39MP0003879_abnormal_hair_cell1.57203308
40MP0005646_abnormal_pituitary_gland1.56109834
41MP0003183_abnormal_peptide_metabolism1.55996041
42MP0001984_abnormal_olfaction1.54983312
43MP0003633_abnormal_nervous_system1.50622872
44MP0002882_abnormal_neuron_morphology1.48588769
45MP0002066_abnormal_motor_capabilities/c1.48566615
46MP0003787_abnormal_imprinting1.46244707
47MP0005645_abnormal_hypothalamus_physiol1.46116707
48MP0003283_abnormal_digestive_organ1.43241059
49MP0002653_abnormal_ependyma_morphology1.29133369
50MP0002152_abnormal_brain_morphology1.27879491
51MP0004233_abnormal_muscle_weight1.26290784
52MP0003631_nervous_system_phenotype1.25331140
53MP0004142_abnormal_muscle_tone1.23930683
54MP0001502_abnormal_circadian_rhythm1.20340043
55MP0008872_abnormal_physiological_respon1.06404235
56MP0001986_abnormal_taste_sensitivity1.01824873
57MP0006276_abnormal_autonomic_nervous0.99270223
58MP0005394_taste/olfaction_phenotype0.98615071
59MP0005499_abnormal_olfactory_system0.98615071
60MP0003075_altered_response_to0.97372796
61MP0004264_abnormal_extraembryonic_tissu0.97158382
62MP0008874_decreased_physiological_sensi0.96868465
63MP0008961_abnormal_basal_metabolism0.95358967
64MP0000569_abnormal_digit_pigmentation0.92563401
65MP0001529_abnormal_vocalization0.92176779
66MP0010234_abnormal_vibrissa_follicle0.92001732
67MP0002229_neurodegeneration0.90471188
68MP0002069_abnormal_eating/drinking_beha0.90261535
69MP0003634_abnormal_glial_cell0.89416423
70MP0005171_absent_coat_pigmentation0.89286944
71MP0001346_abnormal_lacrimal_gland0.89086981
72MP0000566_synostosis0.88184403
73MP0003866_abnormal_defecation0.86566557
74MP0003632_abnormal_nervous_system0.86112095
75MP0001348_abnormal_lacrimal_gland0.85238908
76MP0005310_abnormal_salivary_gland0.84423451
77MP0003121_genomic_imprinting0.83965271
78MP0001485_abnormal_pinna_reflex0.83281258
79MP0003122_maternal_imprinting0.82924446
80MP0001177_atelectasis0.81309376
81MP0003861_abnormal_nervous_system0.80505265
82MP0003690_abnormal_glial_cell0.79811978
83MP0000751_myopathy0.79297614
84MP0001765_abnormal_ion_homeostasis0.79087994
85MP0008877_abnormal_DNA_methylation0.78450246
86MP0001905_abnormal_dopamine_level0.77016692
87MP0004742_abnormal_vestibular_system0.76380353
88MP0001963_abnormal_hearing_physiology0.75840370
89MP0005409_darkened_coat_color0.75752575
90MP0000631_abnormal_neuroendocrine_gland0.74739721
91MP0002752_abnormal_somatic_nervous0.73711665
92MP0008260_abnormal_autophagy0.73204517
93MP0003137_abnormal_impulse_conducting0.69926890
94MP0005167_abnormal_blood-brain_barrier0.69679532
95MP0003172_abnormal_lysosome_physiology0.69497748
96MP0003303_peritoneal_inflammation0.68627409
97MP0006072_abnormal_retinal_apoptosis0.68199297
98MP0003119_abnormal_digestive_system0.67856709
99MP0004130_abnormal_muscle_cell0.67365293
100MP0010769_abnormal_survival0.67245650
101MP0000604_amyloidosis0.65250356
102MP0010768_mortality/aging0.64674081
103MP0005551_abnormal_eye_electrophysiolog0.64484456
104MP0001943_abnormal_respiration0.64114172
105MP0005623_abnormal_meninges_morphology0.63900597
106MP0010770_preweaning_lethality0.62249940
107MP0002082_postnatal_lethality0.62249940
108MP0004145_abnormal_muscle_electrophysio0.62234916
109MP0003890_abnormal_embryonic-extraembry0.62022365
110MP0003938_abnormal_ear_development0.61792146
111MP0000920_abnormal_myelination0.61119161
112MP0001666_abnormal_nutrient_absorption0.60024427
113MP0005535_abnormal_body_temperature0.57990170
114MP0003956_abnormal_body_size0.56965135
115MP0000013_abnormal_adipose_tissue0.56741956
116MP0004085_abnormal_heartbeat0.54344212
117MP0004147_increased_porphyrin_level0.53587360
118MP0002089_abnormal_postnatal_growth/wei0.52725681
119MP0005166_decreased_susceptibility_to0.52572311
120MP0002873_normal_phenotype0.52088355
121MP0001664_abnormal_digestion0.51715210
122MP0001188_hyperpigmentation0.51662883
123MP0005671_abnormal_response_to0.51294901
124MP0005187_abnormal_penis_morphology0.51201594
125MP0002169_no_abnormal_phenotype0.50904176
126MP0010329_abnormal_lipoprotein_level0.50836919
127MP0002876_abnormal_thyroid_physiology0.49565406

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.01436310
2Focal motor seizures (HP:0011153)6.63900284
3Focal seizures (HP:0007359)5.23425749
4Visual hallucinations (HP:0002367)4.81478070
5Epileptic encephalopathy (HP:0200134)4.47433648
6Atonic seizures (HP:0010819)4.26196999
7Febrile seizures (HP:0002373)4.16361674
8Action tremor (HP:0002345)4.00994573
9Progressive cerebellar ataxia (HP:0002073)3.95022686
10Absence seizures (HP:0002121)3.80572128
11Annular pancreas (HP:0001734)3.80009897
12Abnormality of the lower motor neuron (HP:0002366)3.63820324
13Ankle clonus (HP:0011448)3.63235579
14Dysdiadochokinesis (HP:0002075)3.42481020
15Dialeptic seizures (HP:0011146)3.40844160
16Generalized tonic-clonic seizures (HP:0002069)3.36917492
17Supranuclear gaze palsy (HP:0000605)3.35240998
18Broad-based gait (HP:0002136)3.25729976
19Impaired vibration sensation in the lower limbs (HP:0002166)3.19983483
20Gaze-evoked nystagmus (HP:0000640)3.16755726
21Urinary bladder sphincter dysfunction (HP:0002839)3.11307306
22Poor eye contact (HP:0000817)3.08529853
23Depression (HP:0000716)3.01659173
24Dysmetria (HP:0001310)2.97795076
25Abnormal social behavior (HP:0012433)2.93611214
26Impaired social interactions (HP:0000735)2.93611214
27Tetraplegia (HP:0002445)2.87138320
28Postural instability (HP:0002172)2.86921629
29Intention tremor (HP:0002080)2.86753092
30Impaired smooth pursuit (HP:0007772)2.86480952
31Genetic anticipation (HP:0003743)2.83315637
32Abnormal eating behavior (HP:0100738)2.81382474
33Truncal ataxia (HP:0002078)2.81377525
34Urinary urgency (HP:0000012)2.80681239
35Dysmetric saccades (HP:0000641)2.76783898
36Mutism (HP:0002300)2.75058906
37Papilledema (HP:0001085)2.61522764
38Sleep apnea (HP:0010535)2.58598893
39Megalencephaly (HP:0001355)2.55159892
40Peripheral hypomyelination (HP:0007182)2.54297133
41Hemiplegia (HP:0002301)2.52621096
42Spastic gait (HP:0002064)2.49543778
43Anxiety (HP:0000739)2.49213237
44Abnormality of ocular smooth pursuit (HP:0000617)2.49202915
45Amblyopia (HP:0000646)2.48628955
46Torticollis (HP:0000473)2.46826602
47Scanning speech (HP:0002168)2.45686968
48Obstructive sleep apnea (HP:0002870)2.44243328
49Hemiparesis (HP:0001269)2.44146992
50Fetal akinesia sequence (HP:0001989)2.41887588
51Insomnia (HP:0100785)2.41644576
52Abnormality of binocular vision (HP:0011514)2.40383423
53Diplopia (HP:0000651)2.40383423
54Hyperventilation (HP:0002883)2.39082333
55Pointed chin (HP:0000307)2.38823631
56Stereotypic behavior (HP:0000733)2.33880889
57Termporal pattern (HP:0011008)2.32979975
58Insidious onset (HP:0003587)2.32979975
59Cerebral hypomyelination (HP:0006808)2.31640703
60Impaired vibratory sensation (HP:0002495)2.31425910
61Bradykinesia (HP:0002067)2.30700151
62Slow saccadic eye movements (HP:0000514)2.28976143
63Amyotrophic lateral sclerosis (HP:0007354)2.27864833
64Increased circulating renin level (HP:0000848)2.27626972
65Status epilepticus (HP:0002133)2.27261320
66Drooling (HP:0002307)2.26036159
67Excessive salivation (HP:0003781)2.26036159
68Focal dystonia (HP:0004373)2.24555538
69Bronchomalacia (HP:0002780)2.23702792
70Ventricular fibrillation (HP:0001663)2.22045293
71Spastic tetraparesis (HP:0001285)2.16318902
72Clonus (HP:0002169)2.15951777
73Cerebral inclusion bodies (HP:0100314)2.15429764
74Abnormality of the corticospinal tract (HP:0002492)2.14979799
75Rigidity (HP:0002063)2.13349203
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13173495
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.13173495
78Epileptiform EEG discharges (HP:0011182)2.12633808
79Lower limb muscle weakness (HP:0007340)2.11262003
80Eczematoid dermatitis (HP:0000976)2.09198605
81Memory impairment (HP:0002354)2.08913135
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06277458
83EEG with generalized epileptiform discharges (HP:0011198)2.04779201
84Ankyloglossia (HP:0010296)2.04320475
85Neurofibrillary tangles (HP:0002185)2.02192736
86Delusions (HP:0000746)2.01800494
87Progressive inability to walk (HP:0002505)2.00985186
88Resting tremor (HP:0002322)1.99644277
89Pheochromocytoma (HP:0002666)1.99611817
90Hypsarrhythmia (HP:0002521)1.99510589
91Turricephaly (HP:0000262)1.98522033
92Craniofacial dystonia (HP:0012179)1.98144026
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96869404
94Aqueductal stenosis (HP:0002410)1.94185775
95Limb dystonia (HP:0002451)1.93440513
96Diminished motivation (HP:0000745)1.89400600
97Morphological abnormality of the pyramidal tract (HP:0002062)1.88775773
98Generalized myoclonic seizures (HP:0002123)1.87098842
99Abnormality of the periventricular white matter (HP:0002518)1.86458183
100Clumsiness (HP:0002312)1.82752038
101Incomplete penetrance (HP:0003829)1.82217871
102Abnormality of the astrocytes (HP:0100707)1.82161316
103Astrocytoma (HP:0009592)1.82161316
104Polyphagia (HP:0002591)1.80676916
105Specific learning disability (HP:0001328)1.76872985
106Thickened helices (HP:0000391)1.76396026
107Gait ataxia (HP:0002066)1.74296466
108Retrobulbar optic neuritis (HP:0100654)1.72801999
109Optic neuritis (HP:0100653)1.72801999
110Short chin (HP:0000331)1.72448104
111Abnormality of saccadic eye movements (HP:0000570)1.72206136
112Neuronal loss in central nervous system (HP:0002529)1.71037917
113Hyperacusis (HP:0010780)1.70667180
114Hypercortisolism (HP:0001578)1.70211578
115Rapidly progressive (HP:0003678)1.69506205
116Akinesia (HP:0002304)1.68855872
117Apathy (HP:0000741)1.68568412
118Absent speech (HP:0001344)1.68143911
119Lower limb asymmetry (HP:0100559)1.66768567
120CNS hypomyelination (HP:0003429)1.66415300
121Narrow nasal bridge (HP:0000446)1.66347166
122Intellectual disability, profound (HP:0002187)1.64751536
123Neoplasm of the peripheral nervous system (HP:0100007)1.64151799
124Choreoathetosis (HP:0001266)1.63964313
125Dementia (HP:0000726)1.62645766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.09369912
2EPHA44.01370477
3NTRK33.65170301
4MARK13.25075514
5MAP3K42.77372401
6DAPK22.63414777
7MINK12.40871854
8NTRK22.37296773
9TYRO32.32517350
10PAK62.29705923
11DAPK12.18029900
12PRKD32.16816032
13KSR21.96264588
14MAP2K71.94232857
15ICK1.83233725
16CAMKK11.82451175
17NTRK11.65907054
18UHMK11.62318383
19DDR21.62101900
20PRPF4B1.56070960
21PINK11.55758322
22MAP2K41.55673604
23STK381.50244917
24CDK51.47986710
25KSR11.47544277
26FGFR21.47376196
27LATS21.41995868
28TAOK11.39809927
29MAP3K61.39723033
30MAP4K11.34016235
31CDK191.33904428
32PHKG11.31060942
33PHKG21.31060942
34SIK21.28531986
35MAP3K121.21048593
36CASK1.11791550
37RIPK41.11292163
38NEK61.09487052
39MAP3K21.05722372
40CAMK1D1.05193986
41PLK21.04724354
42ALK1.03913461
43FGR1.00658709
44GRK51.00331993
45PRKCG0.99419157
46STK110.99356435
47MAPK130.99278818
48RIPK10.97213316
49CDK150.92021559
50CDK180.91088849
51SGK4940.89698373
52SGK2230.89698373
53FGFR30.88508551
54AKT30.85410873
55RAF10.83689599
56CDK140.82353181
57SGK30.81612713
58CDK11A0.80596083
59PRKCH0.80363999
60ARAF0.80246515
61FGFR40.79124804
62CAMK2A0.78839298
63PNCK0.75544310
64MARK20.75478956
65MAPK120.75135536
66CDC42BPA0.75081094
67SGK10.75053009
68SGK20.74733808
69CAMKK20.74087232
70RET0.73215107
71CAMK2B0.73020280
72FES0.70225427
73NEK10.70082875
74BMX0.69372403
75TNIK0.69247011
76CAMK10.67692195
77PRKD20.67591799
78OXSR10.67406073
79TNK20.66920986
80LMTK20.66338327
81GRK60.65065351
82PDGFRA0.63296708
83SCYL20.62943665
84STK390.61796130
85JAK20.59363583
86CSNK1G20.58805181
87PDK10.58606096
88TXK0.58504392
89IRAK20.57803590
90PRKCZ0.55174237
91MAP3K110.55037100
92MAP3K130.54715610
93RPS6KA30.54494976
94ERBB20.53982188
95MAPK100.53209488
96MATK0.52954637
97MAP2K60.52214012
98DYRK1A0.51504783
99PAK30.51282561
100BMPR20.51236315
101PRKG20.50705580
102PDPK10.50592892
103SMG10.47970519
104SYK0.46356183
105EEF2K0.46137720
106CAMK40.43416719
107CSK0.42845134
108WNK40.42428487
109BRSK10.42234716
110CAMK2G0.41781948
111ITK0.41405096
112TRIB30.40695089
113JAK10.40007678
114TAOK30.39225068
115WNK30.39173605
116FYN0.38074862
117PRKCQ0.37196774
118DMPK0.36700467
119CAMK1G0.36535387
120DYRK1B0.35176853
121MAP3K10.34490294
122WNK10.34433740
123MAPK150.34326907
124MAP3K70.33977452
125DAPK30.31713730
126PTK2B0.30836008

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.33550792
2Synaptic vesicle cycle_Homo sapiens_hsa047213.23642855
3Olfactory transduction_Homo sapiens_hsa047402.94140093
4GABAergic synapse_Homo sapiens_hsa047272.59760501
5Long-term potentiation_Homo sapiens_hsa047202.57520577
6Circadian entrainment_Homo sapiens_hsa047132.51025304
7Glutamatergic synapse_Homo sapiens_hsa047242.46713199
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37388221
9Morphine addiction_Homo sapiens_hsa050322.35338943
10Amphetamine addiction_Homo sapiens_hsa050312.31744457
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26353865
12Dopaminergic synapse_Homo sapiens_hsa047282.09449054
13Salivary secretion_Homo sapiens_hsa049702.07542269
14Gastric acid secretion_Homo sapiens_hsa049711.91638449
15Insulin secretion_Homo sapiens_hsa049111.80597153
16Cholinergic synapse_Homo sapiens_hsa047251.78235424
17Nitrogen metabolism_Homo sapiens_hsa009101.74507913
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71448424
19Long-term depression_Homo sapiens_hsa047301.65654422
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60612714
21Oxytocin signaling pathway_Homo sapiens_hsa049211.56955844
22Renin secretion_Homo sapiens_hsa049241.54313139
23GnRH signaling pathway_Homo sapiens_hsa049121.49617109
24Taste transduction_Homo sapiens_hsa047421.48383285
25Cocaine addiction_Homo sapiens_hsa050301.48263832
26Gap junction_Homo sapiens_hsa045401.47522593
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45407786
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44691304
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38694012
30Calcium signaling pathway_Homo sapiens_hsa040201.36789995
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34582397
32Serotonergic synapse_Homo sapiens_hsa047261.32735157
33Estrogen signaling pathway_Homo sapiens_hsa049151.28090103
34ErbB signaling pathway_Homo sapiens_hsa040121.27521963
35Vitamin B6 metabolism_Homo sapiens_hsa007501.25831687
36Fatty acid biosynthesis_Homo sapiens_hsa000611.23752791
37cAMP signaling pathway_Homo sapiens_hsa040241.22557006
38Glioma_Homo sapiens_hsa052141.22278848
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20685799
40Oocyte meiosis_Homo sapiens_hsa041141.15644549
41Dorso-ventral axis formation_Homo sapiens_hsa043201.14056288
42Type II diabetes mellitus_Homo sapiens_hsa049301.10079327
43Axon guidance_Homo sapiens_hsa043601.09786881
44Collecting duct acid secretion_Homo sapiens_hsa049661.09135344
45Melanogenesis_Homo sapiens_hsa049161.08800674
46mTOR signaling pathway_Homo sapiens_hsa041501.07809493
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02674094
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97888136
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92427966
50Choline metabolism in cancer_Homo sapiens_hsa052310.88757318
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88365634
52B cell receptor signaling pathway_Homo sapiens_hsa046620.88264900
53VEGF signaling pathway_Homo sapiens_hsa043700.88025456
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.86223529
55T cell receptor signaling pathway_Homo sapiens_hsa046600.84831193
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83983903
57Circadian rhythm_Homo sapiens_hsa047100.79366158
58MAPK signaling pathway_Homo sapiens_hsa040100.79220119
59Endometrial cancer_Homo sapiens_hsa052130.77506794
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.76586997
61Histidine metabolism_Homo sapiens_hsa003400.75744779
62Thyroid hormone synthesis_Homo sapiens_hsa049180.75585360
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75081220
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.73710120
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72634354
66Pancreatic secretion_Homo sapiens_hsa049720.72633504
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72231464
68Wnt signaling pathway_Homo sapiens_hsa043100.68292300
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67577022
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67242876
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.66385751
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65272957
73Rap1 signaling pathway_Homo sapiens_hsa040150.65174885
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62458878
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62303537
76Phototransduction_Homo sapiens_hsa047440.60020758
77Colorectal cancer_Homo sapiens_hsa052100.59997049
78Ras signaling pathway_Homo sapiens_hsa040140.59986711
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.59483281
80Hedgehog signaling pathway_Homo sapiens_hsa043400.59386772
81Vibrio cholerae infection_Homo sapiens_hsa051100.58884560
82* Endocytosis_Homo sapiens_hsa041440.58676025
83Non-small cell lung cancer_Homo sapiens_hsa052230.58652657
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58514611
85Hippo signaling pathway_Homo sapiens_hsa043900.57642278
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57346844
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57004125
88Insulin signaling pathway_Homo sapiens_hsa049100.56726115
89Glucagon signaling pathway_Homo sapiens_hsa049220.55850116
90Alcoholism_Homo sapiens_hsa050340.55298263
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54588059
92Bile secretion_Homo sapiens_hsa049760.53838598
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51366017
94Inositol phosphate metabolism_Homo sapiens_hsa005620.50555048
95Renal cell carcinoma_Homo sapiens_hsa052110.49955969
96Cardiac muscle contraction_Homo sapiens_hsa042600.49050795
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.48547785
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48316065
99Dilated cardiomyopathy_Homo sapiens_hsa054140.46350306
100Tight junction_Homo sapiens_hsa045300.46051710
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43761483
102Tuberculosis_Homo sapiens_hsa051520.43427414
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43246839
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.41696383
105Osteoclast differentiation_Homo sapiens_hsa043800.41322656
106ABC transporters_Homo sapiens_hsa020100.39529389
107Chemokine signaling pathway_Homo sapiens_hsa040620.38054429
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37022448
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36678110
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36376917
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36235396
112Mineral absorption_Homo sapiens_hsa049780.35543172
113AMPK signaling pathway_Homo sapiens_hsa041520.33652310
114Arginine biosynthesis_Homo sapiens_hsa002200.33587591
115Prolactin signaling pathway_Homo sapiens_hsa049170.33078030
116Ether lipid metabolism_Homo sapiens_hsa005650.33035668
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32601265
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.32392328

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