RAB11FIP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.46491780
2acrosome reaction (GO:0007340)5.37261291
3sperm motility (GO:0030317)5.33429500
4cell wall macromolecule catabolic process (GO:0016998)5.04990571
5cell wall macromolecule metabolic process (GO:0044036)5.04990571
6acrosome assembly (GO:0001675)4.79456790
7plasma membrane repair (GO:0001778)4.77892051
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.69689212
9skin morphogenesis (GO:0043589)4.64459464
10plasma membrane fusion (GO:0045026)4.61315113
11hemidesmosome assembly (GO:0031581)4.51913164
12negative regulation of potassium ion transmembrane transport (GO:1901380)4.27341003
13sperm-egg recognition (GO:0035036)4.23689138
14multicellular organism reproduction (GO:0032504)3.96789239
15cell-substrate junction assembly (GO:0007044)3.96732995
16cell adhesion mediated by integrin (GO:0033627)3.93649584
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.91515176
18endodermal cell differentiation (GO:0035987)3.86620652
19cell-cell recognition (GO:0009988)3.83499632
20negative regulation of inclusion body assembly (GO:0090084)3.81090303
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.77137990
22binding of sperm to zona pellucida (GO:0007339)3.75595967
23regulation of cilium movement (GO:0003352)3.75592280
24spermatid development (GO:0007286)3.69854420
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.68651855
26protein heterotrimerization (GO:0070208)3.65519639
27protein retention in ER lumen (GO:0006621)3.64302642
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.61161770
29axonemal dynein complex assembly (GO:0070286)3.59331756
30reproduction (GO:0000003)3.58121056
31cilium or flagellum-dependent cell motility (GO:0001539)3.56832435
32collagen fibril organization (GO:0030199)3.54240516
33epithelial cilium movement (GO:0003351)3.52443896
34synaptonemal complex organization (GO:0070193)3.50615309
35motile cilium assembly (GO:0044458)3.49945820
36Golgi transport vesicle coating (GO:0048200)3.48654915
37COPI coating of Golgi vesicle (GO:0048205)3.48654915
38sodium ion export (GO:0071436)3.45847184
39peptidyl-proline hydroxylation (GO:0019511)3.42666123
40synaptonemal complex assembly (GO:0007130)3.42295738
41adherens junction assembly (GO:0034333)3.38846605
42chondrocyte proliferation (GO:0035988)3.33340409
43kidney mesenchyme development (GO:0072074)3.30236055
44carnitine transport (GO:0015879)3.29870669
45amino-acid betaine transport (GO:0015838)3.29870669
46cell communication by electrical coupling (GO:0010644)3.29755517
47synaptic vesicle maturation (GO:0016188)3.29005310
48cardiac myofibril assembly (GO:0055003)3.28647455
49carnitine transmembrane transport (GO:1902603)3.28306153
50calcium ion-dependent exocytosis (GO:0017156)3.27365362
51positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.26322669
52cell-substrate adherens junction assembly (GO:0007045)3.25823396
53focal adhesion assembly (GO:0048041)3.25823396
54cytoskeletal anchoring at plasma membrane (GO:0007016)3.24568299
55left/right pattern formation (GO:0060972)3.22397645
56basement membrane organization (GO:0071711)3.20624230
57desmosome organization (GO:0002934)3.19977148
58sarcomere organization (GO:0045214)3.18771804
59regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.15076870
60extracellular matrix assembly (GO:0085029)3.14295007
61piRNA metabolic process (GO:0034587)3.11797910
62protein hydroxylation (GO:0018126)3.11691153
63regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.07897050
64protein localization to endosome (GO:0036010)3.06484025
65organic cation transport (GO:0015695)3.03974550
66planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03096245
67positive regulation of blood vessel endothelial cell migration (GO:0043536)3.00959100
68substrate-dependent cell migration (GO:0006929)3.00367451
69regulation of microtubule-based movement (GO:0060632)3.00257781
70regulation of inclusion body assembly (GO:0090083)3.00200161
71glutamate secretion (GO:0014047)2.99189263
72sperm capacitation (GO:0048240)2.96266923
73cell communication involved in cardiac conduction (GO:0086065)2.94894120
74type B pancreatic cell proliferation (GO:0044342)2.94862918
75cilium movement (GO:0003341)2.91250337
76regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.87724249
77negative regulation of cell size (GO:0045792)2.87545533
78vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.85986840
79membrane depolarization during action potential (GO:0086010)2.85465371
80stress fiber assembly (GO:0043149)2.84345549
81regulation of synapse structural plasticity (GO:0051823)2.82540052
82microtubule severing (GO:0051013)2.82441059
83collagen metabolic process (GO:0032963)2.82213111
84metanephric mesenchyme development (GO:0072075)2.81347659
85apoptotic cell clearance (GO:0043277)2.81308213
86bone trabecula formation (GO:0060346)2.80921281
87regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80789095
88cell migration involved in heart development (GO:0060973)2.79586815
89barbed-end actin filament capping (GO:0051016)2.78768137
90endothelial cell morphogenesis (GO:0001886)2.77211382
91negative regulation of fatty acid transport (GO:2000192)2.76377729
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76144971
93vascular endothelial growth factor signaling pathway (GO:0038084)2.75115571
94regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.74994877
95carnitine shuttle (GO:0006853)2.74043312
96cardiac muscle contraction (GO:0060048)2.73870124
97cell migration involved in sprouting angiogenesis (GO:0002042)2.72843269
98sequestering of extracellular ligand from receptor (GO:0035581)2.72710088
99endocardial cushion development (GO:0003197)2.72234998
100wound healing, spreading of epidermal cells (GO:0035313)2.71654914
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71629529
102activation of protein kinase A activity (GO:0034199)2.69871003
103myofibril assembly (GO:0030239)2.69046001
104extracellular fibril organization (GO:0043206)2.68808780
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.67751972
106regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.67453476
107negative regulation of chondrocyte differentiation (GO:0032331)2.66985477
108proline transport (GO:0015824)2.65860187
109endothelial cell chemotaxis (GO:0035767)2.65808244
110actin filament depolymerization (GO:0030042)2.65804525
111cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.64918573
112positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64645699
113cellular potassium ion homeostasis (GO:0030007)2.64267554
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63468007
115multicellular organismal macromolecule metabolic process (GO:0044259)2.63301945
116collagen catabolic process (GO:0030574)2.62270220
117male meiosis (GO:0007140)2.61175537
118spermatogenesis (GO:0007283)2.60928072
119extracellular matrix disassembly (GO:0022617)2.60456255
120negative regulation of organelle assembly (GO:1902116)2.60224525
121endocytic recycling (GO:0032456)2.59592420
122single fertilization (GO:0007338)2.59128910
123male gamete generation (GO:0048232)2.59051846
124locomotory exploration behavior (GO:0035641)2.58386318
125positive regulation of fibroblast migration (GO:0010763)2.55149390
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.54025775
127regulation of membrane repolarization (GO:0060306)2.53681482
128regulation of clathrin-mediated endocytosis (GO:2000369)2.53651650
129ventricular system development (GO:0021591)2.53369151
130positive regulation of osteoblast proliferation (GO:0033690)2.53003264
131regulation of p38MAPK cascade (GO:1900744)2.52905466
132tricarboxylic acid cycle (GO:0006099)2.52438087
133hyaluronan catabolic process (GO:0030214)2.51864039
134mesodermal cell differentiation (GO:0048333)2.51561958
135layer formation in cerebral cortex (GO:0021819)2.50691254
136heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.48815580
137negative regulation of potassium ion transport (GO:0043267)2.48636782
138adhesion of symbiont to host (GO:0044406)2.48586822
139multicellular organismal metabolic process (GO:0044236)2.48330345
140virion attachment to host cell (GO:0019062)2.48274732
141adhesion of symbiont to host cell (GO:0044650)2.48274732
142hypotonic response (GO:0006971)2.48257246
143cellular response to vitamin (GO:0071295)2.47962419
144positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.47799600
145regulation of early endosome to late endosome transport (GO:2000641)2.47048218
146regulation of plasminogen activation (GO:0010755)2.46946124
147ventricular cardiac muscle cell action potential (GO:0086005)2.46244572
148atrioventricular valve morphogenesis (GO:0003181)2.46133996
149glycolytic process (GO:0006096)2.45209104
150cortical actin cytoskeleton organization (GO:0030866)2.44422051
151blood vessel endothelial cell migration (GO:0043534)2.44397649
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44183581
153potassium ion import (GO:0010107)2.43811383
154protein targeting to plasma membrane (GO:0072661)2.43805647
155positive regulation of axon extension (GO:0045773)2.43300980
156positive regulation of endothelial cell apoptotic process (GO:2000353)2.41203300
157regulation of transforming growth factor beta1 production (GO:0032908)2.40770120
158regulation of extracellular matrix disassembly (GO:0010715)2.40259578
159multicellular organismal catabolic process (GO:0044243)2.40142603
160retina vasculature morphogenesis in camera-type eye (GO:0061299)2.39811089
161regulation of calcium ion transmembrane transporter activity (GO:1901019)2.39808234
162regulation of calcium ion transmembrane transport (GO:1903169)2.39808234
163fertilization (GO:0009566)2.39793574
164positive regulation of receptor recycling (GO:0001921)2.39717577
165negative regulation of catenin import into nucleus (GO:0035414)2.39331975
166regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39271892
167semaphorin-plexin signaling pathway (GO:0071526)2.38727335
168quaternary ammonium group transport (GO:0015697)2.38046277
169dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37657674
170positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.37572779
171cochlea morphogenesis (GO:0090103)2.37300104
172regulation of integrin activation (GO:0033623)2.36046312
173gamete generation (GO:0007276)2.35681714
174regulation of NFAT protein import into nucleus (GO:0051532)2.35338662
175glomerular visceral epithelial cell development (GO:0072015)2.34680460
176cardiac muscle cell development (GO:0055013)2.34537057
177regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.34136598
178seminiferous tubule development (GO:0072520)2.33890691
179cellular process involved in reproduction in multicellular organism (GO:0022412)2.33657590
180epithelial cell-cell adhesion (GO:0090136)2.33022594
181vesicle coating (GO:0006901)2.31674903
182extracellular matrix organization (GO:0030198)2.30776989
183extracellular structure organization (GO:0043062)2.30084206
184cell volume homeostasis (GO:0006884)2.28483690
185wound healing, spreading of cells (GO:0044319)2.28068805
186actin filament bundle organization (GO:0061572)2.27256962
187actin filament bundle assembly (GO:0051017)2.27256962
188COPII vesicle coating (GO:0048208)2.26413446
189peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.26343534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.60717927
2EZH2_22144423_ChIP-Seq_EOC_Human3.55307126
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.05699323
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49731744
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22954628
6CLOCK_20551151_ChIP-Seq_293T_Human2.06057413
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05154852
8STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92629269
9HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87579435
10UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.82436175
11DROSHA_22980978_ChIP-Seq_HELA_Human1.78816163
12RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78050191
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72745665
14KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69228752
15LXR_22292898_ChIP-Seq_THP-1_Human1.64929696
16* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63243158
17ZNF263_19887448_ChIP-Seq_K562_Human1.63137615
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61132278
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60332783
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.58168788
21* KDM2B_26808549_Chip-Seq_K562_Human1.58065982
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56897257
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.55227107
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54093261
25UBF1/2_26484160_Chip-Seq_HMECs_Human1.53171087
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.52945939
27BRD4_25478319_ChIP-Seq_HGPS_Human1.49671019
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48857520
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48559221
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48559221
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47887672
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.47510280
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47279663
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.45834236
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.45834236
36* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44765984
37CJUN_26792858_Chip-Seq_BT549_Human1.41953019
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.41035647
39ATF3_27146783_Chip-Seq_COLON_Human1.40667045
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39327773
41KDM2B_26808549_Chip-Seq_DND41_Human1.37394773
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36515621
43REST_21632747_ChIP-Seq_MESCs_Mouse1.34858516
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34493055
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33681753
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33448215
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.33096283
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32768205
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32362419
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31982008
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.31187705
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28909101
53ZNF274_21170338_ChIP-Seq_K562_Hela1.27635470
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27219469
55SMC4_20622854_ChIP-Seq_HELA_Human1.26676773
56SMC1_22415368_ChIP-Seq_MEFs_Mouse1.26050588
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25757445
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25748754
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25496577
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24354374
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24035163
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23742766
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23375988
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21532062
65TET1_21490601_ChIP-Seq_MESCs_Mouse1.21271360
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18338467
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18261894
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17692753
69CTCF_27219007_Chip-Seq_Bcells_Human1.17570545
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.16780132
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16581365
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.15930058
73* TP63_22573176_ChIP-Seq_HFKS_Human1.15743875
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15550888
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13542836
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13387455
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.12473714
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11104205
79* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10691616
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10594517
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10187871
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09484421
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.09409603
84TP53_22127205_ChIP-Seq_IMR90_Human1.09294755
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08913815
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08739190
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08424293
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07916688
89* TCF7_22412390_ChIP-Seq_EML_Mouse1.07666822
90* KLF4_19829295_ChIP-Seq_ESCs_Human1.06861785
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.06522451
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05728234
93EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04879911
94RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04879911
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.04345324
96RACK7_27058665_Chip-Seq_MCF-7_Human1.03168051
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.03156319
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02989398
99TP53_18474530_ChIP-ChIP_U2OS_Human1.02150651
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.01919523
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.01574437
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01466726
103* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01334898
104FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00493435
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00413630
106* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99710371
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99581249
108TP53_23651856_ChIP-Seq_MEFs_Mouse0.99460869
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.98745529
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98655544
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98593172
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98363049
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98304314
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.97343937
115* ELK3_25401928_ChIP-Seq_HUVEC_Human0.96813509
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96766102
117* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96405077
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96044692
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95433861
120* OCT4_19829295_ChIP-Seq_ESCs_Human0.95375803
121AHR_22903824_ChIP-Seq_MCF-7_Human0.93380325
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92441251
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92379729
124* P68_20966046_ChIP-Seq_HELA_Human0.92076002
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91840482
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91443602
127BCOR_27268052_Chip-Seq_Bcells_Human0.91220281
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90550420
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.90345667
130KDM2B_26808549_Chip-Seq_JURKAT_Human0.88452025
131RING1B_27294783_Chip-Seq_ESCs_Mouse0.87946305
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87581894
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87029440
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86734607
135NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86699968
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.85205963
137* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84473751
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.83225331
139SPI1_23127762_ChIP-Seq_K562_Human0.82277946
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81721010
141SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81542014
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81412919
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80829445
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79697430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.02554625
2MP0000751_myopathy3.60650053
3MP0002837_dystrophic_cardiac_calcinosis3.23969878
4MP0004084_abnormal_cardiac_muscle3.10757382
5MP0003646_muscle_fatigue3.06806566
6MP0004859_abnormal_synaptic_plasticity2.97245528
7MP0005503_abnormal_tendon_morphology2.94856849
8MP0005257_abnormal_intraocular_pressure2.81743769
9MP0005623_abnormal_meninges_morphology2.79448505
10MP0010368_abnormal_lymphatic_system2.76649350
11MP0003705_abnormal_hypodermis_morpholog2.52424524
12MP0004233_abnormal_muscle_weight2.29138755
13MP0004036_abnormal_muscle_relaxation2.28195332
14MP0004858_abnormal_nervous_system2.21615154
15MP0008438_abnormal_cutaneous_collagen2.18155199
16MP0000749_muscle_degeneration2.14127067
17MP0004215_abnormal_myocardial_fiber2.10339317
18MP0003950_abnormal_plasma_membrane2.10248900
19MP0005023_abnormal_wound_healing2.05816659
20MP0004087_abnormal_muscle_fiber2.02733607
21MP0004130_abnormal_muscle_cell1.96475411
22MP0005670_abnormal_white_adipose1.93509201
23MP0002060_abnormal_skin_morphology1.92833112
24MP0009384_cardiac_valve_regurgitation1.87825782
25MP0003698_abnormal_male_reproductive1.83488128
26MP0000750_abnormal_muscle_regeneration1.83135347
27MP0005330_cardiomyopathy1.81828001
28MP0009046_muscle_twitch1.74459864
29MP0002269_muscular_atrophy1.73201172
30MP0002909_abnormal_adrenal_gland1.71092188
31MP0000767_abnormal_smooth_muscle1.64476720
32MP0003279_aneurysm1.62886848
33MP0002877_abnormal_melanocyte_morpholog1.62183355
34MP0005409_darkened_coat_color1.62117247
35MP0003045_fibrosis1.60027391
36MP0010030_abnormal_orbit_morphology1.59370215
37MP0003329_amyloid_beta_deposits1.58359868
38MP0004145_abnormal_muscle_electrophysio1.58132383
39MP0002896_abnormal_bone_mineralization1.55591783
40MP0003941_abnormal_skin_development1.54958912
41MP0002972_abnormal_cardiac_muscle1.54648334
42MP0003566_abnormal_cell_adhesion1.54331781
43MP0003635_abnormal_synaptic_transmissio1.54030706
44MP0005275_abnormal_skin_tensile1.52815016
45MP0010630_abnormal_cardiac_muscle1.52428715
46MP0005508_abnormal_skeleton_morphology1.52396632
47MP0010352_gastrointestinal_tract_polyps1.51681038
48MP0005620_abnormal_muscle_contractility1.50446344
49MP0005058_abnormal_lysosome_morphology1.50235225
50MP0000747_muscle_weakness1.47786958
51MP0004510_myositis1.46952554
52MP0000762_abnormal_tongue_morphology1.46806117
53MP0001299_abnormal_eye_distance/1.46498696
54MP0004270_analgesia1.46243261
55MP0000678_abnormal_parathyroid_gland1.45863489
56MP0003137_abnormal_impulse_conducting1.45272714
57MP0002106_abnormal_muscle_physiology1.44737785
58MP0001542_abnormal_bone_strength1.44270662
59MP0004484_altered_response_of1.42439367
60MP0003172_abnormal_lysosome_physiology1.42095485
61MP0008775_abnormal_heart_ventricle1.38255443
62MP0000759_abnormal_skeletal_muscle1.35777702
63MP0008961_abnormal_basal_metabolism1.34989121
64MP0001929_abnormal_gametogenesis1.33582464
65MP0006138_congestive_heart_failure1.28027305
66MP0001958_emphysema1.26550270
67MP0005666_abnormal_adipose_tissue1.26478166
68MP0003828_pulmonary_edema1.22795773
69MP0000013_abnormal_adipose_tissue1.22642603
70MP0009840_abnormal_foam_cell1.22363560
71MP0005385_cardiovascular_system_phenoty1.22329622
72MP0001544_abnormal_cardiovascular_syste1.22329622
73MP0009053_abnormal_anal_canal1.21810785
74MP0004085_abnormal_heartbeat1.21532544
75MP0005369_muscle_phenotype1.19675036
76MP0002653_abnormal_ependyma_morphology1.19015914
77MP0005595_abnormal_vascular_smooth1.16135244
78MP0001879_abnormal_lymphatic_vessel1.15863463
79MP0010234_abnormal_vibrissa_follicle1.14536287
80MP0009278_abnormal_bone_marrow1.14069052
81MP0000569_abnormal_digit_pigmentation1.13724337
82MP0004272_abnormal_basement_membrane1.11402277
83MP0002064_seizures1.09788924
84MP0003283_abnormal_digestive_organ1.08373725
85MP0009250_abnormal_appendicular_skeleto1.08177859
86MP0002063_abnormal_learning/memory/cond1.05444939
87MP0001243_abnormal_dermal_layer1.05337688
88MP0000467_abnormal_esophagus_morphology1.05283404
89MP0001849_ear_inflammation1.04543032
90MP0000579_abnormal_nail_morphology1.04531439
91MP0005167_abnormal_blood-brain_barrier1.04519715
92MP0002796_impaired_skin_barrier1.03551236
93MP0005375_adipose_tissue_phenotype1.03404877
94MP0003075_altered_response_to1.03400407
95MP0003091_abnormal_cell_migration1.03242647
96MP0003385_abnormal_body_wall1.01825164
97MP0004811_abnormal_neuron_physiology0.99572745
98MP0006054_spinal_hemorrhage0.99171836
99MP0009780_abnormal_chondrocyte_physiolo0.98523457
100MP0000604_amyloidosis0.98213267
101MP0002161_abnormal_fertility/fecundity0.97490611
102MP0003942_abnormal_urinary_system0.96824167
103MP0003633_abnormal_nervous_system0.95671867
104MP0008569_lethality_at_weaning0.91013361
105MP0003453_abnormal_keratinocyte_physiol0.90474454
106MP0002234_abnormal_pharynx_morphology0.90417343
107MP0002332_abnormal_exercise_endurance0.90166992
108MP0000343_altered_response_to0.90066369
109MP0004185_abnormal_adipocyte_glucose0.89693963
110MP0002108_abnormal_muscle_morphology0.88294849
111MP0002089_abnormal_postnatal_growth/wei0.87257965
112MP0003191_abnormal_cellular_cholesterol0.86775375
113MP0002249_abnormal_larynx_morphology0.86751043
114MP0000733_abnormal_muscle_development0.85722727
115MP0002572_abnormal_emotion/affect_behav0.81611932
116MP0003634_abnormal_glial_cell0.80788501
117MP0000163_abnormal_cartilage_morphology0.80014749
118MP0003303_peritoneal_inflammation0.79572445
119MP0001614_abnormal_blood_vessel0.77408384
120MP0009745_abnormal_behavioral_response0.77119794
121MP0001968_abnormal_touch/_nociception0.76113326
122MP0005451_abnormal_body_composition0.74507628
123MP0005501_abnormal_skin_physiology0.72368204
124MP0000534_abnormal_ureter_morphology0.71698690
125MP0010386_abnormal_urinary_bladder0.71196388
126MP0003115_abnormal_respiratory_system0.70863844
127MP0010771_integument_phenotype0.70717767
128MP0000003_abnormal_adipose_tissue0.70600524
129MP0001765_abnormal_ion_homeostasis0.70114425
130MP0000428_abnormal_craniofacial_morphol0.69950058
131MP0002128_abnormal_blood_circulation0.69891261
132MP0002295_abnormal_pulmonary_circulatio0.69378141
133MP0001440_abnormal_grooming_behavior0.69251013
134MP0000266_abnormal_heart_morphology0.69075705
135MP0003690_abnormal_glial_cell0.69062370
136MP0001915_intracranial_hemorrhage0.68912824
137MP0005076_abnormal_cell_differentiation0.68280682
138MP0002733_abnormal_thermal_nociception0.68120367
139MP0005390_skeleton_phenotype0.67627380
140MP0002734_abnormal_mechanical_nocicepti0.67427528
141MP0000462_abnormal_digestive_system0.66622301
142MP0003221_abnormal_cardiomyocyte_apopto0.66125476
143MP0005197_abnormal_uvea_morphology0.65281707
144MP0003879_abnormal_hair_cell0.64982728
145MP0001348_abnormal_lacrimal_gland0.64773368
146MP0002168_other_aberrant_phenotype0.64635160
147MP0002925_abnormal_cardiovascular_devel0.64402292
148MP0001970_abnormal_pain_threshold0.63610261
149MP0005165_increased_susceptibility_to0.63567324
150MP0003631_nervous_system_phenotype0.63247605
151MP0002932_abnormal_joint_morphology0.61744197
152MP0000537_abnormal_urethra_morphology0.61133380
153MP0005621_abnormal_cell_physiology0.60265280
154MP0002115_abnormal_skeleton_extremities0.60195210
155MP0002113_abnormal_skeleton_development0.59771793

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.74666117
2Absent/shortened dynein arms (HP:0200106)4.62729465
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.62729465
4Sudden death (HP:0001699)3.95029967
5Asymmetric septal hypertrophy (HP:0001670)3.93084592
6Vascular tortuosity (HP:0004948)3.88915990
7Aortic dissection (HP:0002647)3.86722954
8Aortic aneurysm (HP:0004942)3.79596544
9Hyporeflexia of lower limbs (HP:0002600)3.70859316
10Bundle branch block (HP:0011710)3.70791717
11Arterial tortuosity (HP:0005116)3.60406309
12Muscle fiber splitting (HP:0003555)3.55044402
13Cerebral aneurysm (HP:0004944)3.44343626
14Difficulty climbing stairs (HP:0003551)3.40010846
15Exercise-induced myalgia (HP:0003738)3.38961843
16Exercise-induced muscle cramps (HP:0003710)3.31399860
17Follicular hyperkeratosis (HP:0007502)3.26642502
18Difficulty running (HP:0009046)3.25403323
19Wormian bones (HP:0002645)3.24805540
20Increased connective tissue (HP:0009025)3.21972550
21Vertebral compression fractures (HP:0002953)3.21303926
22Abnormality of the lower motor neuron (HP:0002366)3.19916796
23Bladder diverticulum (HP:0000015)3.18400518
24Infertility (HP:0000789)3.15172012
25Nasal polyposis (HP:0100582)3.11202372
26Abnormal respiratory motile cilium physiology (HP:0012261)3.04618744
27Soft skin (HP:0000977)3.02536409
28Abnormality of dentin (HP:0010299)2.98855813
29Upper limb amyotrophy (HP:0009129)2.95135836
30Distal upper limb amyotrophy (HP:0007149)2.95135836
31Ventricular tachycardia (HP:0004756)2.93634021
32Abnormality of the nasal mucosa (HP:0000433)2.93357502
33Ventricular fibrillation (HP:0001663)2.89285679
34Neonatal short-limb short stature (HP:0008921)2.85073711
35Abnormal respiratory motile cilium morphology (HP:0005938)2.82301676
36Abnormal respiratory epithelium morphology (HP:0012253)2.82301676
37Genu recurvatum (HP:0002816)2.78450981
38Hand muscle atrophy (HP:0009130)2.74099659
39Male infertility (HP:0003251)2.72889356
40Ulnar bowing (HP:0003031)2.69542395
41Atrial fibrillation (HP:0005110)2.69090803
42Blue sclerae (HP:0000592)2.66527677
43Abnormality of the calf musculature (HP:0001430)2.62600019
44Rhinitis (HP:0012384)2.61591067
45Dilatation of the ascending aorta (HP:0005111)2.58480173
46Primary atrial arrhythmia (HP:0001692)2.57517970
47Increased variability in muscle fiber diameter (HP:0003557)2.54206313
48Right ventricular cardiomyopathy (HP:0011663)2.49157609
49Mitral regurgitation (HP:0001653)2.47241294
50Slender build (HP:0001533)2.45161233
51Dysmetric saccades (HP:0000641)2.43770672
52Supranuclear gaze palsy (HP:0000605)2.43202268
53EMG: neuropathic changes (HP:0003445)2.42879769
54Mitral valve prolapse (HP:0001634)2.42800081
55Hyperextensible skin (HP:0000974)2.42653781
56Chronic bronchitis (HP:0004469)2.40840379
57Rapidly progressive (HP:0003678)2.39857733
58Supraventricular arrhythmia (HP:0005115)2.39679454
59Supraventricular tachycardia (HP:0004755)2.37773818
60Protrusio acetabuli (HP:0003179)2.37549448
61Calf muscle hypertrophy (HP:0008981)2.34909835
62Syncope (HP:0001279)2.34511975
63EMG: myopathic abnormalities (HP:0003458)2.34141262
64Ventricular arrhythmia (HP:0004308)2.33710449
65Joint laxity (HP:0001388)2.33282348
66Premature rupture of membranes (HP:0001788)2.30140046
67Osteolytic defects of the hand bones (HP:0009699)2.30110769
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.30110769
69Mitral stenosis (HP:0001718)2.28220419
70Abnormal atrioventricular conduction (HP:0005150)2.27842394
71Myoglobinuria (HP:0002913)2.27502518
72Obstructive sleep apnea (HP:0002870)2.26753880
73Elbow flexion contracture (HP:0002987)2.26526125
74Overgrowth (HP:0001548)2.26131573
75Heart block (HP:0012722)2.25104336
76Shallow orbits (HP:0000586)2.24850356
77Type 1 muscle fiber predominance (HP:0003803)2.24482028
78Myotonia (HP:0002486)2.23444989
79Spondylolisthesis (HP:0003302)2.23150361
80Bowel diverticulosis (HP:0005222)2.22458378
81Broad face (HP:0000283)2.20509673
82Abnormality of skeletal muscle fiber size (HP:0012084)2.18765691
83Hyperacusis (HP:0010780)2.17110880
84Abnormality of the acetabulum (HP:0003170)2.16191796
85Distal lower limb muscle weakness (HP:0009053)2.15361060
86Natal tooth (HP:0000695)2.13941183
87Biconcave vertebral bodies (HP:0004586)2.13897289
88Mutism (HP:0002300)2.10149241
89Lower limb amyotrophy (HP:0007210)2.09057118
90Muscle hypertrophy of the lower extremities (HP:0008968)2.07672741
91Peritonitis (HP:0002586)2.07296172
92Broad metatarsal (HP:0001783)2.06289780
93Mildly elevated creatine phosphokinase (HP:0008180)2.05116756
94Visual hallucinations (HP:0002367)2.04813984
95Achilles tendon contracture (HP:0001771)2.03630689
96Increased cerebral lipofuscin (HP:0011813)2.03519511
97Cardiovascular calcification (HP:0011915)2.01870502
98Disproportionate tall stature (HP:0001519)2.01659637
99Neuronal loss in central nervous system (HP:0002529)2.01309748
100Lipoatrophy (HP:0100578)2.01177845
101Myokymia (HP:0002411)2.00794019
102Subaortic stenosis (HP:0001682)2.00710870
103Abnormality of the left ventricular outflow tract (HP:0011103)2.00710870
104Wrist flexion contracture (HP:0001239)1.99720248
105Abnormal ossification of hand bones (HP:0005921)1.98572124
106Generalized amyotrophy (HP:0003700)1.98397976
107Prolonged QT interval (HP:0001657)1.98320856
108Hypoventilation (HP:0002791)1.98171190
109Cerebral inclusion bodies (HP:0100314)1.96886123
110Abnormal ciliary motility (HP:0012262)1.95004970
111Abnormal delivery (HP:0001787)1.94984818
112Abnormality of carpal bone ossification (HP:0006257)1.94537739
113Postural instability (HP:0002172)1.93605418
114Atrioventricular block (HP:0001678)1.92931370
115Aortic regurgitation (HP:0001659)1.92837182
116Spinal rigidity (HP:0003306)1.89535966
117Coxa vara (HP:0002812)1.89235793
118Coronal craniosynostosis (HP:0004440)1.87712506
119Round ear (HP:0100830)1.87296057
120Ectopia lentis (HP:0001083)1.86474964
121Advanced eruption of teeth (HP:0006288)1.85303899
122Abnormal EKG (HP:0003115)1.83771903
123Frequent falls (HP:0002359)1.82119388
124Spastic tetraparesis (HP:0001285)1.81366841
125Neurofibrillary tangles (HP:0002185)1.80166757
126Spinal cord compression (HP:0002176)1.79900829
127Focal seizures (HP:0007359)1.79160707
128Distal lower limb amyotrophy (HP:0008944)1.78358615
129Insomnia (HP:0100785)1.78307312
130Ankle contracture (HP:0006466)1.77841457
131Bowing of the arm (HP:0006488)1.77144364
132Bowed forearm bones (HP:0003956)1.77144364
133Loss of speech (HP:0002371)1.77047652
134Wide anterior fontanel (HP:0000260)1.75982659
135Mild short stature (HP:0003502)1.74512261
136Dysostosis multiplex (HP:0000943)1.74314683
137Scapular winging (HP:0003691)1.74122752
138Joint stiffness (HP:0001387)1.74063183
139Systemic lupus erythematosus (HP:0002725)1.73427543
140Long toe (HP:0010511)1.72166588
141Aortic valve stenosis (HP:0001650)1.71917153
142Generalized muscle weakness (HP:0003324)1.71657865
143Abnormality of the Achilles tendon (HP:0005109)1.70299297
144Hypercortisolism (HP:0001578)1.70179852
145Atrophic scars (HP:0001075)1.69935600
146Bradycardia (HP:0001662)1.69901110
147Axonal loss (HP:0003447)1.69335004
148Short nail (HP:0001799)1.68887581
149Action tremor (HP:0002345)1.68551515
150Global brain atrophy (HP:0002283)1.67834296
151J-shaped sella turcica (HP:0002680)1.67758385
152Congenital glaucoma (HP:0001087)1.67426501
153Fragile skin (HP:0001030)1.67059902
154Aneurysm (HP:0002617)1.66979341
155Amyotrophic lateral sclerosis (HP:0007354)1.66744782
156Cervical subluxation (HP:0003308)1.66441205
157Hypoplasia of the iris (HP:0007676)1.65883799
158Protruding ear (HP:0000411)1.65709068
159Buphthalmos (HP:0000557)1.65098037
160Lymphangioma (HP:0100764)1.64876994
161Renal duplication (HP:0000075)1.63579559
162Thin bony cortex (HP:0002753)1.63543155
163Absent frontal sinuses (HP:0002688)1.63531170
164Gowers sign (HP:0003391)1.63517469
165Osteoarthritis (HP:0002758)1.61202809
166Ankyloglossia (HP:0010296)1.60786007
167Camptodactyly of toe (HP:0001836)1.59304471
168Limb-girdle muscle weakness (HP:0003325)1.55639890
169Abnormality of oral frenula (HP:0000190)1.55249967
170Arnold-Chiari malformation (HP:0002308)1.55135185
171Reduced subcutaneous adipose tissue (HP:0003758)1.55121629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.43089816
2PDK44.43089816
3PRKD34.00163994
4ICK3.31817424
5TESK13.18877577
6TRIB33.08564770
7PDK22.82156873
8TTN2.74412246
9MAP3K92.28289096
10SIK12.09835982
11MET1.98632400
12LMTK21.98259811
13RIPK11.96649769
14PKN21.89499615
15PTK2B1.86417849
16ARAF1.79152196
17PHKG21.73156937
18PHKG11.73156937
19LATS21.69135759
20PRPF4B1.67086150
21TYRO31.67039780
22WNK41.63106874
23LATS11.55145943
24PAK61.52095552
25CAMKK11.51642106
26LIMK11.48712495
27DDR21.43370563
28PDGFRA1.41701955
29IRAK31.41237859
30CDK121.38036912
31WNK11.33324012
32NTRK11.32869907
33DMPK1.30799207
34PINK11.30235160
35PRKD21.29204580
36CAMK1G1.26648544
37SMG11.18864945
38TGFBR21.17561355
39KSR21.14359647
40MAP3K31.10140761
41AKT31.06100243
42TAOK11.05454726
43NEK91.05392878
44MAP3K41.04808856
45MINK11.03690150
46NTRK30.99900481
47NEK10.99200195
48MAP3K130.97701834
49BMX0.96541128
50ROCK20.95453868
51EEF2K0.94362824
52GRK50.94335927
53PDK10.94166797
54ERN10.93904324
55TAOK20.93872447
56DAPK20.93818692
57RIPK40.93088745
58CAMK1D0.91858815
59* STK380.91216862
60ERBB40.90240141
61TRPM70.88887029
62FGFR40.88844148
63MAPKAPK30.87738554
64PDPK10.86817053
65MARK10.82157699
66NTRK20.81564619
67RET0.79557395
68BRAF0.78299436
69PAK30.76839545
70PAK40.74959620
71ABL20.74675670
72DYRK1B0.72473608
73MAP2K40.71388494
74STK390.71202769
75TIE10.70369258
76PTK20.66599033
77EPHA20.66127237
78FER0.63940168
79MATK0.63288686
80FLT30.62389334
81OBSCN0.62327420
82EPHA40.61181452
83CDC42BPA0.59235031
84PAK20.59210421
85CAMKK20.59178306
86MTOR0.59072018
87PNCK0.58395935
88MARK20.57882939
89PRKCH0.57604383
90PIM20.57101876
91PTK60.56960899
92MYLK0.55858863
93EPHB10.54910328
94CAMK2G0.54787991
95STK110.54770719
96MAP2K30.54691503
97MAP3K80.54553623
98STK38L0.53390222
99PRKD10.53100122
100PRKAA10.52163581
101ALK0.50067278
102CDK50.49967595
103PAK10.49907802
104SIK20.49762484
105PDGFRB0.49374233
106GRK70.48455283
107SCYL20.48408774
108DAPK30.47801646
109MAP2K10.46142767
110GSK3A0.43931864
111CAMK10.43734681
112DAPK10.40548496
113CAMK2B0.39887146
114MAP3K70.39645333
115ROCK10.38679270
116MAP3K20.38329710
117CDK150.37556130
118MAP3K10.37398889
119RPS6KA20.37381218
120MAPK120.37320302
121CDK11A0.36540863
122PLK20.36086707
123MAP3K60.35998418
124CAMK40.35487472
125CDK140.34903526
126MOS0.34796140
127PRKG20.34243263
128CAMK2A0.34234413
129PRKCG0.34021893
130MAP3K110.33644437
131SGK4940.33489834
132SGK2230.33489834
133CDK80.33126643
134CDK180.32814281
135MST1R0.31315126
136FGR0.30840052
137ILK0.29084315
138EPHB20.28260681
139SGK30.28200628
140CAMK2D0.27221437

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.42962538
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42827063
3Dilated cardiomyopathy_Homo sapiens_hsa054141.96518746
4Synaptic vesicle cycle_Homo sapiens_hsa047211.89767245
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85953465
6Cardiac muscle contraction_Homo sapiens_hsa042601.78271050
7Fatty acid biosynthesis_Homo sapiens_hsa000611.78024934
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72009896
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71850773
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60693744
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.53417581
12Dorso-ventral axis formation_Homo sapiens_hsa043201.43335805
13Gastric acid secretion_Homo sapiens_hsa049711.43124160
14Long-term potentiation_Homo sapiens_hsa047201.43064746
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42925673
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40066990
17Bladder cancer_Homo sapiens_hsa052191.38902935
18Olfactory transduction_Homo sapiens_hsa047401.38690283
19Prion diseases_Homo sapiens_hsa050201.38502071
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36761183
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35335221
22Renin secretion_Homo sapiens_hsa049241.30063174
23Salivary secretion_Homo sapiens_hsa049701.29767673
24Circadian entrainment_Homo sapiens_hsa047131.25533775
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24765340
26Glucagon signaling pathway_Homo sapiens_hsa049221.23702474
27Estrogen signaling pathway_Homo sapiens_hsa049151.23519044
28Amphetamine addiction_Homo sapiens_hsa050311.23204651
29Small cell lung cancer_Homo sapiens_hsa052221.20386776
30Oxytocin signaling pathway_Homo sapiens_hsa049211.19637506
31Hippo signaling pathway_Homo sapiens_hsa043901.18032559
32Chronic myeloid leukemia_Homo sapiens_hsa052201.15167150
33Focal adhesion_Homo sapiens_hsa045101.12380893
34VEGF signaling pathway_Homo sapiens_hsa043701.12372855
35Vitamin B6 metabolism_Homo sapiens_hsa007501.12148597
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12033713
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10572377
38Insulin secretion_Homo sapiens_hsa049111.10176049
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09683332
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09060165
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07242411
42mTOR signaling pathway_Homo sapiens_hsa041501.04932981
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04380231
44Calcium signaling pathway_Homo sapiens_hsa040201.03661779
45Vibrio cholerae infection_Homo sapiens_hsa051101.01803972
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00228987
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00117589
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00071062
49Axon guidance_Homo sapiens_hsa043600.99718049
50GnRH signaling pathway_Homo sapiens_hsa049120.99216139
51Collecting duct acid secretion_Homo sapiens_hsa049660.98987423
52Glutamatergic synapse_Homo sapiens_hsa047240.98478073
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97864841
54Lysosome_Homo sapiens_hsa041420.97539003
55Dopaminergic synapse_Homo sapiens_hsa047280.95412538
56Glioma_Homo sapiens_hsa052140.94585782
57MicroRNAs in cancer_Homo sapiens_hsa052060.93739825
58cAMP signaling pathway_Homo sapiens_hsa040240.93698549
59ECM-receptor interaction_Homo sapiens_hsa045120.92996415
60* Endocytosis_Homo sapiens_hsa041440.92628685
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92097760
62Type II diabetes mellitus_Homo sapiens_hsa049300.91594389
63Gap junction_Homo sapiens_hsa045400.91398191
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.90797463
65GABAergic synapse_Homo sapiens_hsa047270.89879769
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87587224
67Amoebiasis_Homo sapiens_hsa051460.87461452
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87003441
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.86915989
70Insulin signaling pathway_Homo sapiens_hsa049100.85078284
71Nicotine addiction_Homo sapiens_hsa050330.82915657
72Proteoglycans in cancer_Homo sapiens_hsa052050.82868412
73Galactose metabolism_Homo sapiens_hsa000520.82751464
74Morphine addiction_Homo sapiens_hsa050320.82737769
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82619947
76Cholinergic synapse_Homo sapiens_hsa047250.82409037
77Hedgehog signaling pathway_Homo sapiens_hsa043400.82255121
78Melanoma_Homo sapiens_hsa052180.82213973
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.81567012
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81167950
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80970989
82Thyroid cancer_Homo sapiens_hsa052160.80459067
83Endometrial cancer_Homo sapiens_hsa052130.80116908
84Other glycan degradation_Homo sapiens_hsa005110.79711900
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.79104014
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79023183
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78106482
88AMPK signaling pathway_Homo sapiens_hsa041520.77613291
89HIF-1 signaling pathway_Homo sapiens_hsa040660.76563993
90Insulin resistance_Homo sapiens_hsa049310.75053587
91Taste transduction_Homo sapiens_hsa047420.74609098
92Pyruvate metabolism_Homo sapiens_hsa006200.74320798
93Pancreatic cancer_Homo sapiens_hsa052120.74170308
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.73147197
95TGF-beta signaling pathway_Homo sapiens_hsa043500.72647794
96Pathways in cancer_Homo sapiens_hsa052000.72046739
97Oocyte meiosis_Homo sapiens_hsa041140.71866710
98Salmonella infection_Homo sapiens_hsa051320.70861507
99Tight junction_Homo sapiens_hsa045300.69973831
100Rap1 signaling pathway_Homo sapiens_hsa040150.69330735
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.69188720
102Adherens junction_Homo sapiens_hsa045200.68808220
103Fructose and mannose metabolism_Homo sapiens_hsa000510.68039804
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67357342
105Viral myocarditis_Homo sapiens_hsa054160.66301765
106Notch signaling pathway_Homo sapiens_hsa043300.66020128
107Non-small cell lung cancer_Homo sapiens_hsa052230.64697456
108Cocaine addiction_Homo sapiens_hsa050300.64112751
109MAPK signaling pathway_Homo sapiens_hsa040100.64040305
110Wnt signaling pathway_Homo sapiens_hsa043100.63770840
111Basal cell carcinoma_Homo sapiens_hsa052170.63294057
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63172866
113Renal cell carcinoma_Homo sapiens_hsa052110.63160623
114N-Glycan biosynthesis_Homo sapiens_hsa005100.62851699
115Prostate cancer_Homo sapiens_hsa052150.62211385
116Bile secretion_Homo sapiens_hsa049760.61384117
117Carbon metabolism_Homo sapiens_hsa012000.61042375
118Arginine biosynthesis_Homo sapiens_hsa002200.60939650
119ErbB signaling pathway_Homo sapiens_hsa040120.60715995
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60183181
121Circadian rhythm_Homo sapiens_hsa047100.59666001
122Melanogenesis_Homo sapiens_hsa049160.59337883
123Pancreatic secretion_Homo sapiens_hsa049720.59144300
124Thyroid hormone synthesis_Homo sapiens_hsa049180.59131975
125Mineral absorption_Homo sapiens_hsa049780.58775428
126Inositol phosphate metabolism_Homo sapiens_hsa005620.58623673
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58219256
128Propanoate metabolism_Homo sapiens_hsa006400.58130722
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.57839429
130Ras signaling pathway_Homo sapiens_hsa040140.57785359
131Choline metabolism in cancer_Homo sapiens_hsa052310.55801440
132Protein digestion and absorption_Homo sapiens_hsa049740.55039954
133Long-term depression_Homo sapiens_hsa047300.54949550
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53571169
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52724066

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