RAB12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.24522238
2membrane repolarization during action potential (GO:0086011)5.52705811
3sulfation (GO:0051923)4.54559177
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.52827926
5behavioral response to nicotine (GO:0035095)4.43505844
6sarcoplasmic reticulum calcium ion transport (GO:0070296)4.40862990
7magnesium ion transport (GO:0015693)4.20588741
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.15602134
9plasma membrane repair (GO:0001778)4.09410054
10regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.07384744
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.06743334
12membrane repolarization (GO:0086009)3.98736087
13negative regulation of systemic arterial blood pressure (GO:0003085)3.92520957
14regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.89685647
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.87777763
16regulation of glomerulus development (GO:0090192)3.86719202
17positive regulation of synapse maturation (GO:0090129)3.84656332
18actin-myosin filament sliding (GO:0033275)3.83398878
19muscle filament sliding (GO:0030049)3.83398878
20positive regulation of fatty acid oxidation (GO:0046321)3.78416759
21regulation of germinal center formation (GO:0002634)3.75220221
22interferon-gamma secretion (GO:0072643)3.68354886
23regulation of cell communication by electrical coupling (GO:0010649)3.68329343
24membrane depolarization during action potential (GO:0086010)3.65261606
25regulation of heart rate by cardiac conduction (GO:0086091)3.58493137
26cellular response to ATP (GO:0071318)3.58302223
27positive regulation of cardiac muscle cell differentiation (GO:2000727)3.58192689
28cardiac myofibril assembly (GO:0055003)3.57217508
29sarcomere organization (GO:0045214)3.53832318
30cell proliferation in forebrain (GO:0021846)3.52929499
31myofibril assembly (GO:0030239)3.52039949
32regulation of DNA endoreduplication (GO:0032875)3.51239955
33pharyngeal system development (GO:0060037)3.50336001
34regulation of skeletal muscle contraction (GO:0014819)3.50053912
35regulation of sequestering of triglyceride (GO:0010889)3.47455950
36regulation of phospholipid biosynthetic process (GO:0071071)3.46398459
37regulation of cell proliferation involved in kidney development (GO:1901722)3.46019131
38negative regulation of potassium ion transmembrane transport (GO:1901380)3.45107776
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.43422066
40regulation of synapse maturation (GO:0090128)3.39720114
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.38065625
42cellular response to exogenous dsRNA (GO:0071360)3.35639840
43cardiac muscle cell action potential (GO:0086001)3.35277274
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33075463
45cardiac muscle cell action potential involved in contraction (GO:0086002)3.32936262
46positive regulation of cAMP-mediated signaling (GO:0043950)3.31321507
47DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.27343557
48regulation of mesoderm development (GO:2000380)3.26929588
49positive regulation of fatty acid beta-oxidation (GO:0032000)3.25664169
50negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.25131931
51actin-mediated cell contraction (GO:0070252)3.25112687
52response to inactivity (GO:0014854)3.22683032
53regulation of synapse structural plasticity (GO:0051823)3.18008679
54detection of calcium ion (GO:0005513)3.17285527
55cell communication by electrical coupling (GO:0010644)3.15179078
56vocalization behavior (GO:0071625)3.14088585
57presynaptic membrane organization (GO:0097090)3.11630244
58positive regulation of potassium ion transport (GO:0043268)3.10879594
59positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.08250124
60cardiac muscle contraction (GO:0060048)3.07896540
61response to electrical stimulus (GO:0051602)3.07517421
62cellular response to electrical stimulus (GO:0071257)3.06938883
63parturition (GO:0007567)3.05896468
64prostate gland growth (GO:0060736)3.05068146
65regulation of female receptivity (GO:0045924)3.02361988
66regulation of calcium ion transmembrane transporter activity (GO:1901019)2.99586355
67regulation of calcium ion transmembrane transport (GO:1903169)2.99586355
68multicellular organismal signaling (GO:0035637)2.99294172
69regulation of actin filament-based movement (GO:1903115)2.95928068
70somite development (GO:0061053)2.95271124
71serotonin metabolic process (GO:0042428)2.94752785
72regulation of membrane repolarization (GO:0060306)2.92636295
73negative regulation of platelet activation (GO:0010544)2.88871802
74striated muscle contraction (GO:0006941)2.88455478
75layer formation in cerebral cortex (GO:0021819)2.87559351
76regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.86737360
77gamma-aminobutyric acid transport (GO:0015812)2.86097895
78regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85312832
79cell communication involved in cardiac conduction (GO:0086065)2.85270062
80ovulation cycle (GO:0042698)2.85106889
81positive regulation of glomerulus development (GO:0090193)2.84157562
82positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.83645731
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.82837495
84negative regulation of appetite (GO:0032099)2.81501825
85negative regulation of response to food (GO:0032096)2.81501825
86locomotory exploration behavior (GO:0035641)2.81481116
87regulation of relaxation of muscle (GO:1901077)2.80493629
88regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.79513120
89skeletal muscle contraction (GO:0003009)2.79336873
90neuronal action potential propagation (GO:0019227)2.77604609
91relaxation of cardiac muscle (GO:0055119)2.76365058
92presynaptic membrane assembly (GO:0097105)2.76237239
93regulation of secondary heart field cardioblast proliferation (GO:0003266)2.76161020
94regulation of cardioblast proliferation (GO:0003264)2.76161020
95response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.75631876
96DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72542306
97regulation of sarcomere organization (GO:0060297)2.72254095
98synaptic vesicle maturation (GO:0016188)2.72143788
99opsonization (GO:0008228)2.71681115
100regulation of tight junction assembly (GO:2000810)2.71287080
101cellular anion homeostasis (GO:0030002)2.70202079
102regulation of glutamate receptor signaling pathway (GO:1900449)2.70106805
103epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.69594309
104potassium ion homeostasis (GO:0055075)2.69463553
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69359633
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67761121
107action potential (GO:0001508)2.65832034
108activation of protein kinase A activity (GO:0034199)2.64367567
109synaptic vesicle exocytosis (GO:0016079)2.63670876
110flavonoid metabolic process (GO:0009812)2.63337690
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.63211203
112actin filament-based movement (GO:0030048)2.62999766
113otic vesicle formation (GO:0030916)2.62727430
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62105778
115regulation of striated muscle contraction (GO:0006942)2.61951985
116glutamate secretion (GO:0014047)2.61699070
117skeletal muscle adaptation (GO:0043501)2.61059177
118dentate gyrus development (GO:0021542)2.60763569
119actomyosin structure organization (GO:0031032)2.60641841
120regulation of potassium ion transport (GO:0043266)2.60409958
121positive regulation of cation channel activity (GO:2001259)2.60234791
122primary amino compound metabolic process (GO:1901160)2.59845724
123interkinetic nuclear migration (GO:0022027)2.59647454
1243-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58309156
125purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58309156
126potassium ion import (GO:0010107)2.53772700
127glutamate receptor signaling pathway (GO:0007215)2.53645519
128regulation of dendritic spine morphogenesis (GO:0061001)2.53209764
129cellular potassium ion homeostasis (GO:0030007)2.52931749
130regulation of long-term neuronal synaptic plasticity (GO:0048169)2.52803308
131branching involved in labyrinthine layer morphogenesis (GO:0060670)2.51941855
132positive regulation of metanephros development (GO:0072216)2.49962825
133cardiac muscle hypertrophy (GO:0003300)2.46848244
134regulation of cation channel activity (GO:2001257)2.45536493
135neuron recognition (GO:0008038)2.44869927
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.44614509
137NADH dehydrogenase complex assembly (GO:0010257)2.44614509
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44614509
139kynurenine metabolic process (GO:0070189)2.44597600
140negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.44180441
141lymphangiogenesis (GO:0001946)2.43311953
142muscle cell cellular homeostasis (GO:0046716)2.42543093
143negative regulation of calcium ion transmembrane transport (GO:1903170)2.42007097
144negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.42007097
145protein localization to synapse (GO:0035418)2.41585188
146striated muscle hypertrophy (GO:0014897)2.39300357
147membrane assembly (GO:0071709)2.38093525
148female mating behavior (GO:0060180)2.37252547
149aorta morphogenesis (GO:0035909)2.36463939
150tooth mineralization (GO:0034505)2.36261164
151regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.35869365
152regulation of acyl-CoA biosynthetic process (GO:0050812)2.34615624
153positive regulation of potassium ion transmembrane transport (GO:1901381)2.33197938
154regulation of potassium ion transmembrane transport (GO:1901379)2.32845097
155regulation of cardiac muscle contraction (GO:0055117)2.32051250
156synaptic vesicle docking involved in exocytosis (GO:0016081)2.30373254
157exploration behavior (GO:0035640)2.30057693
158cardiac conduction (GO:0061337)2.29123515
159negative regulation of potassium ion transport (GO:0043267)2.27387148
160neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.27121136
161regulation of synaptic vesicle exocytosis (GO:2000300)2.27055661
162ventricular cardiac muscle cell action potential (GO:0086005)2.26892612
163muscle contraction (GO:0006936)2.26824374
164regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26613917
165muscle hypertrophy (GO:0014896)2.26128412
166negative regulation of protein localization to cell surface (GO:2000009)2.25772978
167axon extension (GO:0048675)2.25378836
168regulation of potassium ion transmembrane transporter activity (GO:1901016)2.25056806
169dendrite morphogenesis (GO:0048813)2.24934021
170regulation of cardiac muscle cell contraction (GO:0086004)2.24832392
171adrenergic receptor signaling pathway (GO:0071875)2.24747009
172proline transport (GO:0015824)2.23625495
173dendritic spine morphogenesis (GO:0060997)2.23407372
174relaxation of muscle (GO:0090075)2.22943771
175regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.22551282
176striated muscle adaptation (GO:0014888)2.22292988
177axonal fasciculation (GO:0007413)2.21924788
178carnitine shuttle (GO:0006853)2.20905878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97628913
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.67800554
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.58395274
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29030848
5GBX2_23144817_ChIP-Seq_PC3_Human2.79907480
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61269629
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46228133
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33968564
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33674156
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33674156
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.32942662
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27531630
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23016556
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13619590
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13541969
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99313149
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.98877077
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.98862476
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95757339
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.94149221
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88659186
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.77411032
23DROSHA_22980978_ChIP-Seq_HELA_Human1.74087018
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.74066089
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.71098984
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69671367
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.69263534
28VDR_22108803_ChIP-Seq_LS180_Human1.60671717
29AR_21572438_ChIP-Seq_LNCaP_Human1.60431590
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59442119
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56203396
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55816761
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49056194
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45052682
35RNF2_27304074_Chip-Seq_NSC_Mouse1.44902111
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.44379062
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44319111
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.42706871
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.42685041
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.42453532
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41203755
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35396236
43* REST_21632747_ChIP-Seq_MESCs_Mouse1.33391008
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32806418
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31519829
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31519829
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31241180
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29421087
49ZNF274_21170338_ChIP-Seq_K562_Hela1.28964936
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28781075
51TP53_18474530_ChIP-ChIP_U2OS_Human1.28723483
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27951646
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26950015
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25545508
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25397314
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24901083
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24410021
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21454916
59EWS_26573619_Chip-Seq_HEK293_Human1.20796576
60P300_19829295_ChIP-Seq_ESCs_Human1.20604507
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.20581346
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.20300390
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17847545
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16977030
65TP53_16413492_ChIP-PET_HCT116_Human1.16921519
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16776281
67AHR_22903824_ChIP-Seq_MCF-7_Human1.16771405
68AR_25329375_ChIP-Seq_VCAP_Human1.16440792
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16168074
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.14738299
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13749718
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.13429274
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.12941766
74* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12758262
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12717711
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12266534
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12221324
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07886881
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07776897
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07578680
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07271485
82FUS_26573619_Chip-Seq_HEK293_Human1.07238884
83BCAT_22108803_ChIP-Seq_LS180_Human1.07017061
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06097643
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.05974931
86IRF1_19129219_ChIP-ChIP_H3396_Human1.05429173
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05376611
88* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05138650
89KDM2B_26808549_Chip-Seq_REH_Human1.04325425
90AR_19668381_ChIP-Seq_PC3_Human1.04029889
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.03411509
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02890975
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.02593786
94IGF1R_20145208_ChIP-Seq_DFB_Human1.02474741
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.02256751
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.02256751
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01584082
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00459090
99RXR_22108803_ChIP-Seq_LS180_Human1.00306047
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99453351
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.99244979
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.99069860
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98715715
104FLI1_21867929_ChIP-Seq_TH2_Mouse0.97552166
105TAF15_26573619_Chip-Seq_HEK293_Human0.97546373
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.97438421
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97430708
108* CJUN_26792858_Chip-Seq_BT549_Human0.96567522
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96128922
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95595541
111STAT3_23295773_ChIP-Seq_U87_Human0.95491264
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94946077
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93863226
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92170578
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91908321
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90186301
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.90118606
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89846125
119CBP_20019798_ChIP-Seq_JUKART_Human0.89846125
120KDM2B_26808549_Chip-Seq_K562_Human0.89678166
121TCF4_23295773_ChIP-Seq_U87_Human0.89281767
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.89035283
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88974007
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.87798239
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.87558618
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.87307635
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.86873755
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86844731
129ER_23166858_ChIP-Seq_MCF-7_Human0.86731671
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86583913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.14029391
2MP0004859_abnormal_synaptic_plasticity3.85713441
3MP0000751_myopathy3.76803036
4MP0003646_muscle_fatigue3.62771924
5MP0004145_abnormal_muscle_electrophysio3.24071698
6MP0004130_abnormal_muscle_cell2.87725166
7MP0004084_abnormal_cardiac_muscle2.78583877
8MP0005646_abnormal_pituitary_gland2.76075514
9MP0004036_abnormal_muscle_relaxation2.74333908
10MP0004215_abnormal_myocardial_fiber2.64254276
11MP0004885_abnormal_endolymph2.63516636
12MP0000749_muscle_degeneration2.60892737
13MP0003635_abnormal_synaptic_transmissio2.37286360
14MP0003879_abnormal_hair_cell2.32625147
15MP0004270_analgesia2.30942387
16MP0001485_abnormal_pinna_reflex2.23940242
17MP0005620_abnormal_muscle_contractility2.20305782
18MP0009780_abnormal_chondrocyte_physiolo2.19878112
19MP0004484_altered_response_of2.18630211
20MP0000569_abnormal_digit_pigmentation2.18440802
21MP0004087_abnormal_muscle_fiber2.12883377
22MP0005330_cardiomyopathy2.07357067
23MP0002106_abnormal_muscle_physiology2.06664238
24MP0002972_abnormal_cardiac_muscle2.03649621
25MP0004510_myositis1.97564032
26MP0003880_abnormal_central_pattern1.93720102
27MP0002160_abnormal_reproductive_system1.87991380
28MP0002063_abnormal_learning/memory/cond1.87558293
29MP0002138_abnormal_hepatobiliary_system1.86217952
30MP0000747_muscle_weakness1.80376860
31MP0009745_abnormal_behavioral_response1.78665517
32MP0005369_muscle_phenotype1.76527981
33MP0000049_abnormal_middle_ear1.72314603
34MP0000750_abnormal_muscle_regeneration1.71220442
35MP0003303_peritoneal_inflammation1.69142354
36MP0009250_abnormal_appendicular_skeleto1.66361875
37MP0000759_abnormal_skeletal_muscle1.63394877
38MP0004134_abnormal_chest_morphology1.62012869
39MP0003137_abnormal_impulse_conducting1.60134149
40MP0002064_seizures1.58901167
41MP0005623_abnormal_meninges_morphology1.56819980
42MP0003724_increased_susceptibility_to1.54182852
43MP0005670_abnormal_white_adipose1.52883613
44MP0001440_abnormal_grooming_behavior1.51636179
45MP0004085_abnormal_heartbeat1.51182153
46MP0002909_abnormal_adrenal_gland1.50378516
47MP0005385_cardiovascular_system_phenoty1.49672795
48MP0001544_abnormal_cardiovascular_syste1.49672795
49MP0000631_abnormal_neuroendocrine_gland1.48584198
50MP0008775_abnormal_heart_ventricle1.48479583
51MP0006138_congestive_heart_failure1.46191872
52MP0004858_abnormal_nervous_system1.46011094
53MP0002638_abnormal_pupillary_reflex1.45953023
54MP0002876_abnormal_thyroid_physiology1.45106222
55MP0004142_abnormal_muscle_tone1.43608541
56MP0000013_abnormal_adipose_tissue1.42471470
57MP0008872_abnormal_physiological_respon1.41620541
58MP0002332_abnormal_exercise_endurance1.40524603
59MP0009046_muscle_twitch1.38991961
60MP0000678_abnormal_parathyroid_gland1.38056667
61MP0005167_abnormal_blood-brain_barrier1.37933383
62MP0004233_abnormal_muscle_weight1.37931518
63MP0001501_abnormal_sleep_pattern1.37597418
64MP0002572_abnormal_emotion/affect_behav1.37234938
65MP0001968_abnormal_touch/_nociception1.34984765
66MP0002269_muscular_atrophy1.32098669
67MP0009053_abnormal_anal_canal1.30840420
68MP0005389_reproductive_system_phenotype1.29901906
69MP0002734_abnormal_mechanical_nocicepti1.27166487
70MP0004185_abnormal_adipocyte_glucose1.25065792
71MP0004272_abnormal_basement_membrane1.25011387
72MP0006072_abnormal_retinal_apoptosis1.23783878
73MP0010630_abnormal_cardiac_muscle1.23401115
74MP0002736_abnormal_nociception_after1.20775950
75MP0005171_absent_coat_pigmentation1.18651984
76MP0001879_abnormal_lymphatic_vessel1.18061019
77MP0003195_calcinosis1.17541339
78MP0006292_abnormal_olfactory_placode1.12807771
79MP0001486_abnormal_startle_reflex1.12408424
80MP0001542_abnormal_bone_strength1.10383640
81MP0002089_abnormal_postnatal_growth/wei1.10122902
82MP0003828_pulmonary_edema1.09579630
83MP0002272_abnormal_nervous_system1.08014219
84MP0002108_abnormal_muscle_morphology1.07316315
85MP0008438_abnormal_cutaneous_collagen1.06763343
86MP0008569_lethality_at_weaning1.03406303
87MP0002067_abnormal_sensory_capabilities1.03003141
88MP0005187_abnormal_penis_morphology1.00180431
89MP0005423_abnormal_somatic_nervous0.99310360
90MP0001502_abnormal_circadian_rhythm0.98727519
91MP0002234_abnormal_pharynx_morphology0.98690435
92MP0000026_abnormal_inner_ear0.97786773
93MP0005248_abnormal_Harderian_gland0.97766511
94MP0001765_abnormal_ion_homeostasis0.96936244
95MP0010368_abnormal_lymphatic_system0.96643646
96MP0003329_amyloid_beta_deposits0.96542232
97MP0004924_abnormal_behavior0.93972754
98MP0005386_behavior/neurological_phenoty0.93972754
99MP0000778_abnormal_nervous_system0.93844213
100MP0002733_abnormal_thermal_nociception0.93266584
101MP0005535_abnormal_body_temperature0.93233300
102MP0003638_abnormal_response/metabolism_0.92802508
103MP0005595_abnormal_vascular_smooth0.92713323
104MP0000383_abnormal_hair_follicle0.92533768
105MP0002735_abnormal_chemical_nociception0.91621624
106MP0001958_emphysema0.91069375
107MP0002184_abnormal_innervation0.89654022
108MP0005551_abnormal_eye_electrophysiolog0.89600598
109MP0008877_abnormal_DNA_methylation0.89469712
110MP0001905_abnormal_dopamine_level0.89222203
111MP0001963_abnormal_hearing_physiology0.88449116
112MP0003942_abnormal_urinary_system0.85994053
113MP0003221_abnormal_cardiomyocyte_apopto0.85926137
114MP0009384_cardiac_valve_regurgitation0.83675158
115MP0003075_altered_response_to0.83333777
116MP0003633_abnormal_nervous_system0.82740097
117MP0003938_abnormal_ear_development0.81723928
118MP0002127_abnormal_cardiovascular_syste0.81217085
119MP0001970_abnormal_pain_threshold0.80334257
120MP0002557_abnormal_social/conspecific_i0.80174705
121MP0002163_abnormal_gland_morphology0.79506268
122MP0010386_abnormal_urinary_bladder0.78594781
123MP0003937_abnormal_limbs/digits/tail_de0.77720008
124MP0000733_abnormal_muscle_development0.77483004
125MP0004133_heterotaxia0.77180048
126MP0004811_abnormal_neuron_physiology0.76730680
127MP0001299_abnormal_eye_distance/0.75517242
128MP0002066_abnormal_motor_capabilities/c0.75065967
129MP0003045_fibrosis0.74776285
130MP0003690_abnormal_glial_cell0.74140656
131MP0000343_altered_response_to0.73981434
132MP0002971_abnormal_brown_adipose0.73794726
133MP0006276_abnormal_autonomic_nervous0.72684208
134MP0000230_abnormal_systemic_arterial0.70267025
135MP0002896_abnormal_bone_mineralization0.69902456
136MP0003705_abnormal_hypodermis_morpholog0.68421651
137MP0002295_abnormal_pulmonary_circulatio0.68094998
138MP0005165_increased_susceptibility_to0.67924304
139MP0003091_abnormal_cell_migration0.66374164
140MP0002090_abnormal_vision0.66169385
141MP0005275_abnormal_skin_tensile0.65791994
142MP0003385_abnormal_body_wall0.64415190
143MP0002877_abnormal_melanocyte_morpholog0.64378296

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.37130181
2Exercise-induced muscle cramps (HP:0003710)4.95307473
3Muscle hypertrophy of the lower extremities (HP:0008968)4.94508505
4Calf muscle hypertrophy (HP:0008981)4.88889609
5Sudden death (HP:0001699)4.72839470
6Muscle fiber inclusion bodies (HP:0100299)4.37986078
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.32534844
8Type 1 muscle fiber predominance (HP:0003803)4.23446822
9Abnormality of the calf musculature (HP:0001430)4.10171356
10Genetic anticipation (HP:0003743)4.01142623
11Muscle fiber splitting (HP:0003555)4.00142965
12Nemaline bodies (HP:0003798)3.92277661
13Focal motor seizures (HP:0011153)3.73295919
14Short 1st metacarpal (HP:0010034)3.70559316
15Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.70559316
16Abnormality of the proximal phalanges of the hand (HP:0009834)3.66761898
17EMG: myopathic abnormalities (HP:0003458)3.64832119
18Difficulty running (HP:0009046)3.58470623
19Decreased circulating renin level (HP:0003351)3.53741017
20Conjunctival hamartoma (HP:0100780)3.51536026
21Short hallux (HP:0010109)3.46055810
22Progressive cerebellar ataxia (HP:0002073)3.44297100
23Morphological abnormality of the middle ear (HP:0008609)3.41985181
24Hyporeflexia of lower limbs (HP:0002600)3.41048594
25Atrial fibrillation (HP:0005110)3.34814413
26Abnormality of the left ventricular outflow tract (HP:0011103)3.31014780
27Subaortic stenosis (HP:0001682)3.31014780
28Persistence of primary teeth (HP:0006335)3.28732791
29Difficulty climbing stairs (HP:0003551)3.24761891
30Aplasia/Hypoplasia of the hallux (HP:0008362)3.22144371
31Primary atrial arrhythmia (HP:0001692)3.21817067
32Abnormality of the 1st metacarpal (HP:0010009)3.18221728
33Myoglobinuria (HP:0002913)3.16569804
34Abolished electroretinogram (ERG) (HP:0000550)3.16394232
35Short femoral neck (HP:0100864)3.11018173
36Ventricular tachycardia (HP:0004756)3.10994974
37Increased connective tissue (HP:0009025)3.09733824
38Myotonia (HP:0002486)3.08648879
39Abnormality of the middle phalanges of the toes (HP:0010183)3.05924770
40Abnormality of the renal collecting system (HP:0004742)3.05892747
41Periauricular skin pits (HP:0100277)2.98761094
42Preauricular pit (HP:0004467)2.98761094
43Supraventricular tachycardia (HP:0004755)2.98189174
44Bundle branch block (HP:0011710)2.96896097
45Supraventricular arrhythmia (HP:0005115)2.96563378
46Fibular aplasia (HP:0002990)2.96447434
47Hemiplegia (HP:0002301)2.96431153
48Stenosis of the external auditory canal (HP:0000402)2.92267877
49Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.90352515
50Paralysis (HP:0003470)2.85922723
51Absent phalangeal crease (HP:0006109)2.84988785
52Syncope (HP:0001279)2.82497624
53Short phalanx of the thumb (HP:0009660)2.81314352
54Symphalangism affecting the phalanges of the hand (HP:0009773)2.76465196
55Visual hallucinations (HP:0002367)2.75318533
56Spinal rigidity (HP:0003306)2.74254984
57Agitation (HP:0000713)2.73905654
58Increased variability in muscle fiber diameter (HP:0003557)2.73433207
59Clumsiness (HP:0002312)2.72863777
60Hamartoma of the eye (HP:0010568)2.71980550
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.70958632
62Myopathic facies (HP:0002058)2.70325431
63Prolonged QT interval (HP:0001657)2.70133423
64Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.69317396
65Asymmetric septal hypertrophy (HP:0001670)2.68012875
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65374782
67Short 4th metacarpal (HP:0010044)2.65374782
68Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.65286571
69Oligodontia (HP:0000677)2.64765854
70Focal seizures (HP:0007359)2.64135956
71Abnormality of the phalanges of the 5th finger (HP:0004213)2.62000339
72Lipoatrophy (HP:0100578)2.56772658
73Abnormality of skeletal muscle fiber size (HP:0012084)2.52867820
74Abnormality of the nasal septum (HP:0000419)2.51592999
75Pendular nystagmus (HP:0012043)2.48073262
76Abnormality of binocular vision (HP:0011514)2.46726960
77Diplopia (HP:0000651)2.46726960
78Muscle stiffness (HP:0003552)2.44219094
79Congenital, generalized hypertrichosis (HP:0004540)2.44102338
80Fused cervical vertebrae (HP:0002949)2.44078497
81Frequent falls (HP:0002359)2.42095222
82Buphthalmos (HP:0000557)2.41233424
83Abnormal finger flexion creases (HP:0006143)2.40690249
84Distal arthrogryposis (HP:0005684)2.39134292
85Bone cyst (HP:0012062)2.38246251
86Right ventricular cardiomyopathy (HP:0011663)2.37752780
87Round ear (HP:0100830)2.34703513
88Congenital sensorineural hearing impairment (HP:0008527)2.31955656
89Generalized tonic-clonic seizures (HP:0002069)2.31691789
90Goiter (HP:0000853)2.30848769
91Synostosis of carpal bones (HP:0005048)2.30564629
92Adactyly (HP:0009776)2.30017748
93Skin pits (HP:0100276)2.29550782
94Mildly elevated creatine phosphokinase (HP:0008180)2.26342233
95Atonic seizures (HP:0010819)2.25131727
96Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.24883236
97Radial bowing (HP:0002986)2.24633761
98Furrowed tongue (HP:0000221)2.23946119
99Hyperkalemia (HP:0002153)2.22267651
100Meningioma (HP:0002858)2.21090948
101Abnormality of the frontal sinuses (HP:0002687)2.20731767
102Absence seizures (HP:0002121)2.19948213
103Ventricular arrhythmia (HP:0004308)2.19158610
104Aplasia/Hypoplasia of the fibula (HP:0006492)2.16466717
105Lower limb amyotrophy (HP:0007210)2.16266953
106Abnormality of the shoulder girdle musculature (HP:0001435)2.16026920
107Neck muscle weakness (HP:0000467)2.15583760
108Abnormal EKG (HP:0003115)2.14731098
109Osteomalacia (HP:0002749)2.13869878
110Lip pit (HP:0100267)2.12474651
111Anomalous pulmonary venous return (HP:0010772)2.12163901
112Porencephaly (HP:0002132)2.11585484
113Pancreatic cysts (HP:0001737)2.10032385
114Small hand (HP:0200055)2.09483676
115Asplenia (HP:0001746)2.09345505
116Limb-girdle muscle weakness (HP:0003325)2.08015079
117Broad metatarsal (HP:0001783)2.07885336
118Muscular dystrophy (HP:0003560)2.06609129
119Keratoconus (HP:0000563)2.05901646
120Increased corneal curvature (HP:0100692)2.05901646
121Heart block (HP:0012722)2.05397280
122Ventricular fibrillation (HP:0001663)2.05091498
123Hypoplasia of the uterus (HP:0000013)2.04528697
124Congenital stationary night blindness (HP:0007642)2.04265917
125Nephronophthisis (HP:0000090)2.03971608
126Aplasia/Hypoplasia of the tibia (HP:0005772)2.03885179
127Aplasia/hypoplasia of the femur (HP:0005613)2.03675850
128Mesomelia (HP:0003027)2.03476164
129Slender build (HP:0001533)2.02549060
130Decreased central vision (HP:0007663)2.02141777
131Broad-based gait (HP:0002136)2.01781062
132Gaze-evoked nystagmus (HP:0000640)2.01532378
133Hypoplasia of the ulna (HP:0003022)1.99144144
134Pancreatic fibrosis (HP:0100732)1.98900398
135Scapular winging (HP:0003691)1.98784789
136Incomplete penetrance (HP:0003829)1.97968527
137Megalencephaly (HP:0001355)1.97963886
138Impaired smooth pursuit (HP:0007772)1.96893634
139Dialeptic seizures (HP:0011146)1.96112160
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95746109
141Abnormal atrioventricular conduction (HP:0005150)1.95571423
142Dilated cardiomyopathy (HP:0001644)1.95385831
143Left ventricular hypertrophy (HP:0001712)1.91803476
144Rimmed vacuoles (HP:0003805)1.91005978
145Myokymia (HP:0002411)1.90836110
146Pheochromocytoma (HP:0002666)1.88757682
147Absent speech (HP:0001344)1.88103600
148Distal lower limb amyotrophy (HP:0008944)1.87638175
149Dysmetric saccades (HP:0000641)1.86503661
150Central scotoma (HP:0000603)1.83745859
151Gowers sign (HP:0003391)1.83389447
152Rapidly progressive (HP:0003678)1.83048843
153Action tremor (HP:0002345)1.81594247
154Epileptic encephalopathy (HP:0200134)1.78651222
155Febrile seizures (HP:0002373)1.78274481
156Poor eye contact (HP:0000817)1.77500007
157Palpitations (HP:0001962)1.77074213
158Anxiety (HP:0000739)1.76316213
159Rhabdomyolysis (HP:0003201)1.75016391
160Supranuclear gaze palsy (HP:0000605)1.73740046
161Retinal atrophy (HP:0001105)1.73480210
162Hypoplastic ischia (HP:0003175)1.72773181
163Shoulder girdle muscle weakness (HP:0003547)1.72651620
164Cerebral inclusion bodies (HP:0100314)1.70824976
165Ulnar deviation of the wrist (HP:0003049)1.70211549
166Limb-girdle muscle atrophy (HP:0003797)1.69769046
167Hyperventilation (HP:0002883)1.69757377
168Urinary bladder sphincter dysfunction (HP:0002839)1.66997637
169Retinal dysplasia (HP:0007973)1.65969710
170Depression (HP:0000716)1.65080590
171Distal lower limb muscle weakness (HP:0009053)1.64460973
172Type II lissencephaly (HP:0007260)1.63983088
173Abnormality of the musculature of the pelvis (HP:0001469)1.63973402
174Abnormality of the hip-girdle musculature (HP:0001445)1.63973402
175Atrioventricular block (HP:0001678)1.63223364
176Neoplasm of the adrenal gland (HP:0100631)1.60480858
177Ankle clonus (HP:0011448)1.59400355
178Impaired social interactions (HP:0000735)1.59309044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.31435410
2PHKG23.15263833
3PHKG13.15263833
4GRK12.85014387
5ADRBK22.75778933
6BLK2.59056439
7TLK12.58049155
8OBSCN2.54437285
9MARK12.39929378
10EPHA42.34643912
11RIPK42.33999449
12DMPK2.25311851
13NTRK32.25069967
14MAP3K42.00420554
15TRIB31.80647253
16PRKD31.77401480
17TAOK31.72257089
18BMPR1B1.67259348
19MAP3K91.66334925
20NEK91.63721902
21MAP2K41.56613252
22KSR21.53968129
23SGK4941.53884090
24SGK2231.53884090
25MINK11.50272097
26DAPK21.45721779
27LMTK21.45139940
28TNIK1.41000332
29PLK21.40781818
30PTK2B1.40575511
31ACVR1B1.39988548
32PAK61.38606785
33MAP2K71.37580067
34TIE11.36244861
35RIPK11.35313622
36PAK31.30361069
37LATS21.24811619
38PIK3CA1.21289296
39PRKD21.20932536
40MUSK1.20550492
41PINK11.18607765
42FER1.17754035
43ARAF1.16748581
44MYLK1.16475211
45PNCK1.15104048
46ERBB31.12077496
47AKT31.11992465
48PDK41.11234001
49PDK31.11234001
50PKN21.07820593
51NTRK21.07264384
52RPS6KA61.04464065
53CAMK1G1.04458782
54PDGFRA1.02693394
55CAMKK11.01775599
56MAPKAPK31.01112046
57KSR10.99636096
58SIK20.99585801
59MAPK120.96142291
60CAMK2A0.93223689
61TXK0.92285062
62RET0.92135741
63TAF10.91041466
64STK240.90848481
65IKBKB0.89101295
66ZAK0.88396340
67FES0.88081640
68ADRBK10.87880889
69GRK70.87849726
70WNK40.87833578
71TGFBR20.84577519
72BMPR20.84258075
73CDK50.84042847
74PDK20.83549471
75MOS0.82208133
76GRK50.81827413
77PRKCE0.81496071
78CAMK2D0.81209070
79RPS6KL10.80506341
80RPS6KC10.80506341
81MAP3K70.79908913
82CAMKK20.79625847
83MAPKAPK50.78686972
84NTRK10.78308136
85DDR20.77877274
86TRPM70.77746206
87MAPK130.77629894
88STK380.76969849
89NME10.75946480
90SGK10.75525292
91PRKCH0.75156106
92PRKACA0.73767931
93PRKD10.70730999
94MAP3K120.70511519
95ROCK10.70286607
96BMX0.69889532
97MAP3K10.69105258
98EPHB10.68805533
99MAP3K20.66410463
100INSRR0.66220771
101STK390.65030886
102MAPK40.63980054
103HIPK20.63225983
104CASK0.63137062
105PRKCG0.62783528
106CAMK2G0.62612641
107SYK0.62507870
108EPHA30.62247110
109FRK0.61027050
110ERBB20.60707956
111FGR0.60177117
112PDPK10.60094435
113LATS10.58777185
114SGK30.58058982
115CAMK10.57003728
116PKN10.56586172
117FGFR30.56533086
118SGK20.55913196
119EPHB20.55876111
120MAPK70.55205637
121ILK0.54977434
122TEC0.54883095
123CDK90.54157987
124CSNK1G20.53405040
125PRKAA20.53170048
126STK110.52945559
127MAP2K10.52096763
128PRKACG0.52083574
129PIK3CG0.51898328
130PTK60.51787233
131CDC42BPA0.50869139
132PRKAA10.50782708
133MAP3K130.49088795
134CAMK2B0.48608855
135MAP3K50.48403888
136WNK10.47811843
137RPS6KA20.47446078
138RPS6KA50.47210483
139TYRO30.47204119
140STK30.46473014
141PDGFRB0.46165797
142RAF10.45805023
143MAP2K60.45588464
144CAMK40.44920787
145CHUK0.44370503
146CSK0.43083377
147RPS6KA30.41434243
148PRKG10.41338361

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.68821658
2Dilated cardiomyopathy_Homo sapiens_hsa054142.27605029
3Sulfur metabolism_Homo sapiens_hsa009202.05208998
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04778347
5Cardiac muscle contraction_Homo sapiens_hsa042602.02922234
6Nicotine addiction_Homo sapiens_hsa050332.02047741
7Circadian entrainment_Homo sapiens_hsa047131.89322638
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77499274
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76174250
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74258824
11Long-term potentiation_Homo sapiens_hsa047201.72108624
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69895727
13GABAergic synapse_Homo sapiens_hsa047271.69034182
14Renin secretion_Homo sapiens_hsa049241.64889368
15Oxytocin signaling pathway_Homo sapiens_hsa049211.63940855
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63173775
17Glutamatergic synapse_Homo sapiens_hsa047241.62678912
18Systemic lupus erythematosus_Homo sapiens_hsa053221.61065879
19Morphine addiction_Homo sapiens_hsa050321.56239869
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.54997659
21Synaptic vesicle cycle_Homo sapiens_hsa047211.52713910
22Olfactory transduction_Homo sapiens_hsa047401.51873397
23Gastric acid secretion_Homo sapiens_hsa049711.49296430
24Salivary secretion_Homo sapiens_hsa049701.47673361
25Phototransduction_Homo sapiens_hsa047441.47283020
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.46155729
27Insulin secretion_Homo sapiens_hsa049111.41696432
28Calcium signaling pathway_Homo sapiens_hsa040201.41339593
29Amphetamine addiction_Homo sapiens_hsa050311.40749104
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37663503
31Dopaminergic synapse_Homo sapiens_hsa047281.36408811
32Cholinergic synapse_Homo sapiens_hsa047251.33548272
33Long-term depression_Homo sapiens_hsa047301.28793488
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28149755
35Melanoma_Homo sapiens_hsa052181.27298277
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23834252
37Type II diabetes mellitus_Homo sapiens_hsa049301.19635905
38GnRH signaling pathway_Homo sapiens_hsa049121.19076398
39Dorso-ventral axis formation_Homo sapiens_hsa043201.11190595
40cAMP signaling pathway_Homo sapiens_hsa040241.11098216
41Serotonergic synapse_Homo sapiens_hsa047261.10811261
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.10090300
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09861444
44Gap junction_Homo sapiens_hsa045401.08136389
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04525228
46Taste transduction_Homo sapiens_hsa047421.04056267
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03564547
48Alcoholism_Homo sapiens_hsa050341.01332668
49Alzheimers disease_Homo sapiens_hsa050101.00344421
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96539223
51Asthma_Homo sapiens_hsa053100.96138981
52Nitrogen metabolism_Homo sapiens_hsa009100.96096742
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93172076
54Viral myocarditis_Homo sapiens_hsa054160.91196008
55Cocaine addiction_Homo sapiens_hsa050300.90867437
56Linoleic acid metabolism_Homo sapiens_hsa005910.90477826
57Focal adhesion_Homo sapiens_hsa045100.90215197
58Estrogen signaling pathway_Homo sapiens_hsa049150.89958577
59Glioma_Homo sapiens_hsa052140.89565729
60Axon guidance_Homo sapiens_hsa043600.86807307
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85981722
62Glucagon signaling pathway_Homo sapiens_hsa049220.85465041
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85078226
64Tryptophan metabolism_Homo sapiens_hsa003800.84021250
65Amoebiasis_Homo sapiens_hsa051460.80605748
66Melanogenesis_Homo sapiens_hsa049160.79995169
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.79945583
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79211630
69Oxidative phosphorylation_Homo sapiens_hsa001900.78314861
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77801371
71Insulin resistance_Homo sapiens_hsa049310.77037336
72VEGF signaling pathway_Homo sapiens_hsa043700.76979868
73Insulin signaling pathway_Homo sapiens_hsa049100.76626794
74Collecting duct acid secretion_Homo sapiens_hsa049660.76089005
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75704389
76Parkinsons disease_Homo sapiens_hsa050120.73916550
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73803837
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73541108
79Chemical carcinogenesis_Homo sapiens_hsa052040.71792636
80MAPK signaling pathway_Homo sapiens_hsa040100.71189565
81Retinol metabolism_Homo sapiens_hsa008300.69657210
82Prion diseases_Homo sapiens_hsa050200.69154032
83Renal cell carcinoma_Homo sapiens_hsa052110.68250066
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64543675
85ErbB signaling pathway_Homo sapiens_hsa040120.64038951
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63648417
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.63616236
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62794507
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62780557
90Rap1 signaling pathway_Homo sapiens_hsa040150.58894286
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58791644
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58288694
93Salmonella infection_Homo sapiens_hsa051320.57972301
94Vitamin digestion and absorption_Homo sapiens_hsa049770.57686949
95African trypanosomiasis_Homo sapiens_hsa051430.56725126
96Platelet activation_Homo sapiens_hsa046110.56498906
97Rheumatoid arthritis_Homo sapiens_hsa053230.56304299
98mTOR signaling pathway_Homo sapiens_hsa041500.55834274
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.55793438
100Adherens junction_Homo sapiens_hsa045200.55617698
101Proteoglycans in cancer_Homo sapiens_hsa052050.55606484
102Hedgehog signaling pathway_Homo sapiens_hsa043400.55501054
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.55321246
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55286009
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53999949
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53927260
107ECM-receptor interaction_Homo sapiens_hsa045120.53819096
108Ras signaling pathway_Homo sapiens_hsa040140.53524540
109PPAR signaling pathway_Homo sapiens_hsa033200.52866059
110Choline metabolism in cancer_Homo sapiens_hsa052310.52370046
111Basal cell carcinoma_Homo sapiens_hsa052170.51101754
112Tight junction_Homo sapiens_hsa045300.51076026
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50826793
114Propanoate metabolism_Homo sapiens_hsa006400.50569505
115Endometrial cancer_Homo sapiens_hsa052130.50295776
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49847563
117Type I diabetes mellitus_Homo sapiens_hsa049400.49835288
118Vibrio cholerae infection_Homo sapiens_hsa051100.49821697
119Selenocompound metabolism_Homo sapiens_hsa004500.49727365
120Circadian rhythm_Homo sapiens_hsa047100.49468438
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49464301
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.49462932
123Tuberculosis_Homo sapiens_hsa051520.49310274
124Pancreatic secretion_Homo sapiens_hsa049720.47432760
125Thyroid hormone synthesis_Homo sapiens_hsa049180.47232915
126Ovarian steroidogenesis_Homo sapiens_hsa049130.46638874
127Chemokine signaling pathway_Homo sapiens_hsa040620.46393784
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46141622
129Phagosome_Homo sapiens_hsa041450.45736192
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45435358
131Renin-angiotensin system_Homo sapiens_hsa046140.45227303
132Glycerolipid metabolism_Homo sapiens_hsa005610.45184047
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44248278
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38337580
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38153637
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.35963698
137ABC transporters_Homo sapiens_hsa020100.35844603
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35639402
139Prolactin signaling pathway_Homo sapiens_hsa049170.32597372
140TGF-beta signaling pathway_Homo sapiens_hsa043500.32202665

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