RAB13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.62986210
2ribosomal small subunit assembly (GO:0000028)6.18124731
3establishment of protein localization to endoplasmic reticulum (GO:0072599)5.96773638
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.81082027
5protein localization to endoplasmic reticulum (GO:0070972)5.79591512
6viral life cycle (GO:0019058)5.38783626
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.28711921
8cellular protein complex disassembly (GO:0043624)5.23259269
9ATP synthesis coupled proton transport (GO:0015986)5.11804268
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.11804268
11lymph vessel development (GO:0001945)5.00120954
12translational initiation (GO:0006413)4.91262661
13ribosomal large subunit biogenesis (GO:0042273)4.73016903
14omega-hydroxylase P450 pathway (GO:0097267)4.52101563
15protein complex disassembly (GO:0043241)4.44797881
16epoxygenase P450 pathway (GO:0019373)4.39056056
17G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.36879436
18protein targeting to membrane (GO:0006612)4.32733198
19epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.28260346
20basement membrane organization (GO:0071711)4.22581986
21macromolecular complex disassembly (GO:0032984)4.16131505
22retina vasculature morphogenesis in camera-type eye (GO:0061299)4.15193964
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.11414335
24chaperone-mediated protein transport (GO:0072321)4.00076725
25respiratory electron transport chain (GO:0022904)3.93009864
26regulation of heart morphogenesis (GO:2000826)3.92187135
27translation (GO:0006412)3.90273617
28electron transport chain (GO:0022900)3.84455763
29collagen fibril organization (GO:0030199)3.83252155
30chondrocyte proliferation (GO:0035988)3.79107190
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.76689767
32protein heterotrimerization (GO:0070208)3.70764032
33glomerular basement membrane development (GO:0032836)3.65695128
34mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.61875846
35paraxial mesoderm development (GO:0048339)3.57102394
36embryonic skeletal joint morphogenesis (GO:0060272)3.56724031
37axon extension involved in axon guidance (GO:0048846)3.53026350
38neuron projection extension involved in neuron projection guidance (GO:1902284)3.53026350
39mesenchymal cell proliferation (GO:0010463)3.49771612
40ribonucleoprotein complex biogenesis (GO:0022613)3.45957359
41metanephric mesenchyme development (GO:0072075)3.44079622
42lymphangiogenesis (GO:0001946)3.43126086
43hippo signaling (GO:0035329)3.42496274
44nuclear-transcribed mRNA catabolic process (GO:0000956)3.41176899
45gap junction assembly (GO:0016264)3.38861688
46regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.37129487
47pattern specification involved in kidney development (GO:0061004)3.36017949
48cell migration involved in heart development (GO:0060973)3.35010062
49kidney mesenchyme development (GO:0072074)3.32823072
50mesenchyme morphogenesis (GO:0072132)3.30695888
51mRNA catabolic process (GO:0006402)3.26673528
52viral transcription (GO:0019083)3.23173285
53cochlea morphogenesis (GO:0090103)3.21557199
54cartilage morphogenesis (GO:0060536)3.19399199
55outer ear morphogenesis (GO:0042473)3.18953780
56phagocytosis, recognition (GO:0006910)3.17902584
57negative regulation of chondrocyte differentiation (GO:0032331)3.17303766
58cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.16738253
59neural crest cell development (GO:0014032)3.16045855
60organ induction (GO:0001759)3.15842259
61translational termination (GO:0006415)3.14323674
62positive regulation of extracellular matrix organization (GO:1903055)3.12630976
63* establishment of protein localization to membrane (GO:0090150)3.12258797
64endocardial cushion morphogenesis (GO:0003203)3.12167844
65positive regulation of protein kinase C signaling (GO:0090037)3.11655886
66positive regulation of epithelial to mesenchymal transition (GO:0010718)3.09643044
67regulation of mitochondrial translation (GO:0070129)3.07368790
68establishment of integrated proviral latency (GO:0075713)3.06294286
69establishment of planar polarity (GO:0001736)3.05861631
70establishment of tissue polarity (GO:0007164)3.05861631
71planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01166721
72respiratory tube development (GO:0030323)2.96013977
73middle ear morphogenesis (GO:0042474)2.94750587
74vascular endothelial growth factor signaling pathway (GO:0038084)2.94129211
75RNA catabolic process (GO:0006401)2.94051354
76protein neddylation (GO:0045116)2.93020975
77cellular component biogenesis (GO:0044085)2.91795842
78notochord development (GO:0030903)2.91086370
79collagen metabolic process (GO:0032963)2.90740956
80cell adhesion mediated by integrin (GO:0033627)2.90464725
81wound healing, spreading of epidermal cells (GO:0035313)2.87548223
82maternal placenta development (GO:0001893)2.87224677
83mesenchymal cell development (GO:0014031)2.86876816
84negative regulation of cartilage development (GO:0061037)2.86639794
85protein maturation by protein folding (GO:0022417)2.86605261
86cardiac epithelial to mesenchymal transition (GO:0060317)2.86293523
87endodermal cell differentiation (GO:0035987)2.85646464
88regulation of organ formation (GO:0003156)2.83929180
89protein targeting (GO:0006605)2.83899257
90epithelial cell-cell adhesion (GO:0090136)2.82992576
91regulation of mesenchymal cell apoptotic process (GO:2001053)2.82627333
92regulation of endothelial cell differentiation (GO:0045601)2.82580439
93positive regulation of cartilage development (GO:0061036)2.81526924
94formation of translation preinitiation complex (GO:0001731)2.78853999
95glomerular visceral epithelial cell development (GO:0072015)2.78843826
96endothelial cell morphogenesis (GO:0001886)2.77970588
97wound healing, spreading of cells (GO:0044319)2.77274012
98epithelial to mesenchymal transition (GO:0001837)2.77199535
99cell proliferation involved in metanephros development (GO:0072203)2.76567674
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74736315
101mesenchyme development (GO:0060485)2.73604244
102cell surface receptor signaling pathway involved in heart development (GO:0061311)2.73034712
103branching involved in salivary gland morphogenesis (GO:0060445)2.72968811
104collagen catabolic process (GO:0030574)2.72873091
105cell proliferation involved in kidney development (GO:0072111)2.72106606
106midgut development (GO:0007494)2.71127706
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.70429492
108termination of RNA polymerase III transcription (GO:0006386)2.70429492
109mesenchymal cell differentiation involved in kidney development (GO:0072161)2.69594649
110mesenchymal cell differentiation involved in renal system development (GO:2001012)2.69594649
111negative regulation of catenin import into nucleus (GO:0035414)2.69522303
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69519867
113ATP biosynthetic process (GO:0006754)2.68109811
114regulation of SMAD protein import into nucleus (GO:0060390)2.67795876
115multicellular organismal macromolecule metabolic process (GO:0044259)2.67160244
116SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66883498
117morphogenesis of an endothelium (GO:0003159)2.66762412
118endothelial tube morphogenesis (GO:0061154)2.66762412
119Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66658333
120glomerular epithelial cell development (GO:0072310)2.66575246
121convergent extension (GO:0060026)2.65156630
122polarized epithelial cell differentiation (GO:0030859)2.64839489
123translational elongation (GO:0006414)2.64692673
124positive regulation of BMP signaling pathway (GO:0030513)2.64120122
125maturation of SSU-rRNA (GO:0030490)2.61801506
126regulation of mesenchymal cell proliferation (GO:0010464)2.61783342
127protein targeting to ER (GO:0045047)2.61257361
128lung-associated mesenchyme development (GO:0060484)2.58769609
129short-term memory (GO:0007614)2.58479452
130cotranslational protein targeting to membrane (GO:0006613)2.57367180
131purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56566989
132establishment of protein localization to organelle (GO:0072594)2.56430522
133purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.56137049
134positive regulation of mesenchymal cell proliferation (GO:0002053)2.55942467
135regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.55591976
136skin morphogenesis (GO:0043589)2.55032087
137craniofacial suture morphogenesis (GO:0097094)2.54951597
138proteasome assembly (GO:0043248)2.54937720
139vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.53782248
140regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.53656038
141regulation of transforming growth factor beta2 production (GO:0032909)2.53487586
142multicellular organismal metabolic process (GO:0044236)2.53378872
143positive regulation of endothelial cell differentiation (GO:0045603)2.52892246
144endothelial cell proliferation (GO:0001935)2.52373222
145mesenchymal to epithelial transition (GO:0060231)2.51760150
146virion attachment to host cell (GO:0019062)2.50923484
147adhesion of symbiont to host cell (GO:0044650)2.50923484
148protein localization to membrane (GO:0072657)2.49882450
149establishment of viral latency (GO:0019043)2.49759770
150regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.49404140
151nucleobase-containing small molecule interconversion (GO:0015949)2.49206003
152hydrogen ion transmembrane transport (GO:1902600)2.48779639
153non-canonical Wnt signaling pathway (GO:0035567)2.46914555
154regulation of integrin-mediated signaling pathway (GO:2001044)2.46189611
155regulation of establishment of planar polarity (GO:0090175)2.45606809
156inner mitochondrial membrane organization (GO:0007007)2.44724004
157regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.42836958
158protein complex biogenesis (GO:0070271)2.40829291
159muscle cell migration (GO:0014812)2.40781837
160lateral sprouting from an epithelium (GO:0060601)2.40310227
161ribonucleoside triphosphate biosynthetic process (GO:0009201)2.36933948
162bone trabecula formation (GO:0060346)2.36418430
163L-serine metabolic process (GO:0006563)2.36234090
164protein targeting to mitochondrion (GO:0006626)2.35613925
165rRNA modification (GO:0000154)2.34380719
166nuclear envelope reassembly (GO:0031468)2.31998806
167mitotic nuclear envelope reassembly (GO:0007084)2.31998806
168cellular component disassembly (GO:0022411)2.28021118
169CENP-A containing nucleosome assembly (GO:0034080)2.27807744
170chromatin remodeling at centromere (GO:0031055)2.26859105
171establishment of protein localization to mitochondrion (GO:0072655)2.26285280
172heterochromatin organization (GO:0070828)2.26161203
173negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.21297897
174negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.20695757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.87753135
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.44622186
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.10236776
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.77923360
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36527242
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19672080
7CLOCK_20551151_ChIP-Seq_293T_Human3.19425120
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.13235959
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94202325
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.66949478
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.57875888
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.55091009
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46310191
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.45894357
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42539821
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.36133628
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30273041
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.28316533
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.28316533
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.28316533
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.13863881
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07941948
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03048420
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.02139985
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.99154375
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98678781
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97215014
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.92634841
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.86716819
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81194438
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80232995
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.77235680
33ELK1_19687146_ChIP-ChIP_HELA_Human1.75396138
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75332117
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74394331
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74121684
37KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.73295503
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70949743
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.69944980
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68143412
41AR_21909140_ChIP-Seq_LNCAP_Human1.66273634
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65933399
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64896145
44* TP63_19390658_ChIP-ChIP_HaCaT_Human1.64156934
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64138566
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.61281196
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56501000
48* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.56142647
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51399808
50ZNF263_19887448_ChIP-Seq_K562_Human1.51319286
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.51020826
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50090800
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49870468
54XRN2_22483619_ChIP-Seq_HELA_Human1.49784933
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49249523
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48361826
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.47666694
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.43445411
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.42885225
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41275953
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40984225
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39134589
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34683031
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34217743
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34144927
66BRD4_25478319_ChIP-Seq_HGPS_Human1.33861739
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31500162
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30488545
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30036496
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29956801
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29837692
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29223889
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.29020408
74* SRF_21415370_ChIP-Seq_HL-1_Mouse1.28953870
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28624472
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28173486
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27654681
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27535467
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24549665
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24394866
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24363130
82* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23559415
83CJUN_26792858_Chip-Seq_BT549_Human1.22194132
84* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22172275
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21268465
86SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19800972
87ATF3_27146783_Chip-Seq_COLON_Human1.19478782
88OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19217992
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17897748
90DCP1A_22483619_ChIP-Seq_HELA_Human1.17197950
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15715817
92* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15602955
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14893905
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14812117
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14341404
96* RACK7_27058665_Chip-Seq_MCF-7_Human1.14324172
97RXR_22158963_ChIP-Seq_LIVER_Mouse1.14258173
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14254717
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14254717
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13627869
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13578936
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12741206
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12658466
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12576085
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12573472
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.12208187
107TTF2_22483619_ChIP-Seq_HELA_Human1.12163488
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.11828775
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10604921
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10495886
111NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10395865
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09738156
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07803185
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.07727502
115ETS1_20019798_ChIP-Seq_JURKAT_Human1.07557729
116GABP_19822575_ChIP-Seq_HepG2_Human1.07423820
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07250926
118NANOG_16153702_ChIP-ChIP_HESCs_Human1.07165711
119SOX17_20123909_ChIP-Seq_XEN_Mouse1.06618583
120SOX2_16153702_ChIP-ChIP_HESCs_Human1.06203062
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05744276
122PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05394556
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05003284
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04212279
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03384046
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02984052
127SOX2_20726797_ChIP-Seq_SW620_Human1.02708013
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00906709
129* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00241065
130* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99493973
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98904514
132YY1_21170310_ChIP-Seq_MESCs_Mouse0.96978068
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96074557
134* SA1_22415368_ChIP-Seq_MEFs_Mouse0.93435306
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93393518
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.93191842
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90254214
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89496800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.51053185
2MP0005503_abnormal_tendon_morphology3.58056743
3MP0004272_abnormal_basement_membrane3.52480493
4MP0003705_abnormal_hypodermis_morpholog3.29608862
5MP0010030_abnormal_orbit_morphology3.25631505
6MP0005275_abnormal_skin_tensile2.86299394
7MP0003279_aneurysm2.76340290
8MP0001879_abnormal_lymphatic_vessel2.70919941
9MP0003385_abnormal_body_wall2.65362707
10MP0005623_abnormal_meninges_morphology2.57537747
11MP0003186_abnormal_redox_activity2.47462237
12MP0009250_abnormal_appendicular_skeleto2.20785122
13MP0010368_abnormal_lymphatic_system2.20721346
14MP0006292_abnormal_olfactory_placode2.18023212
15MP0002249_abnormal_larynx_morphology2.12994571
16MP0005257_abnormal_intraocular_pressure2.12800872
17MP0002282_abnormal_trachea_morphology2.05891935
18MP0009053_abnormal_anal_canal2.02528936
19MP0001958_emphysema2.01191620
20MP0002254_reproductive_system_inflammat1.97462536
21MP0003942_abnormal_urinary_system1.96557571
22MP0005508_abnormal_skeleton_morphology1.94473839
23MP0009384_cardiac_valve_regurgitation1.90866552
24MP0000049_abnormal_middle_ear1.87046189
25MP0003941_abnormal_skin_development1.75724451
26MP0000534_abnormal_ureter_morphology1.69680198
27MP0002932_abnormal_joint_morphology1.65920958
28MP0003566_abnormal_cell_adhesion1.63423975
29MP0002938_white_spotting1.55471488
30MP0003806_abnormal_nucleotide_metabolis1.53288169
31MP0000767_abnormal_smooth_muscle1.52063392
32MP0003123_paternal_imprinting1.43532472
33MP0003115_abnormal_respiratory_system1.42632955
34MP0002295_abnormal_pulmonary_circulatio1.41106983
35MP0000428_abnormal_craniofacial_morphol1.40206607
36MP0005023_abnormal_wound_healing1.38299817
37MP0009379_abnormal_foot_pigmentation1.37064373
38MP0000163_abnormal_cartilage_morphology1.33608943
39MP0000516_abnormal_urinary_system1.32463431
40MP0005367_renal/urinary_system_phenotyp1.32463431
41MP0000343_altered_response_to1.31139532
42MP0000749_muscle_degeneration1.30517785
43MP0000762_abnormal_tongue_morphology1.30291964
44MP0000750_abnormal_muscle_regeneration1.28788071
45MP0002060_abnormal_skin_morphology1.25980826
46MP0000537_abnormal_urethra_morphology1.25815426
47MP0000733_abnormal_muscle_development1.25546592
48MP0003828_pulmonary_edema1.24560110
49MP0004957_abnormal_blastocyst_morpholog1.22712785
50MP0001849_ear_inflammation1.21579227
51MP0005058_abnormal_lysosome_morphology1.18074489
52MP0003567_abnormal_fetal_cardiomyocyte1.17474276
53MP0003755_abnormal_palate_morphology1.16871573
54MP0009697_abnormal_copulation1.13191344
55MP0006054_spinal_hemorrhage1.11683700
56MP0002111_abnormal_tail_morphology1.11366131
57MP0002115_abnormal_skeleton_extremities1.09953737
58MP0002108_abnormal_muscle_morphology1.07592174
59MP0001293_anophthalmia1.07485013
60MP0009840_abnormal_foam_cell1.07234686
61MP0004858_abnormal_nervous_system1.06623916
62MP0000432_abnormal_head_morphology1.05838857
63MP0003950_abnormal_plasma_membrane1.01725750
64MP0003937_abnormal_limbs/digits/tail_de1.01535506
65MP0002102_abnormal_ear_morphology1.01102173
66MP0000566_synostosis1.00900819
67MP0003122_maternal_imprinting1.00562223
68MP0003935_abnormal_craniofacial_develop1.00046585
69MP0002116_abnormal_craniofacial_bone0.99612029
70MP0005390_skeleton_phenotype0.99212564
71MP0005248_abnormal_Harderian_gland0.98015292
72MP0003091_abnormal_cell_migration0.97253264
73MP0000579_abnormal_nail_morphology0.97252717
74MP0002233_abnormal_nose_morphology0.96340037
75MP0004084_abnormal_cardiac_muscle0.95658308
76MP0004510_myositis0.95148642
77MP0005197_abnormal_uvea_morphology0.95127750
78MP0002139_abnormal_hepatobiliary_system0.92842433
79MP0001881_abnormal_mammary_gland0.92375593
80MP0002697_abnormal_eye_size0.92163739
81MP0008789_abnormal_olfactory_epithelium0.91688992
82MP0001614_abnormal_blood_vessel0.91526811
83MP0006138_congestive_heart_failure0.91253791
84MP0002128_abnormal_blood_circulation0.91185530
85MP0002109_abnormal_limb_morphology0.91074235
86MP0002113_abnormal_skeleton_development0.90275656
87MP0003283_abnormal_digestive_organ0.90220301
88MP0002085_abnormal_embryonic_tissue0.89775357
89MP0008932_abnormal_embryonic_tissue0.89723730
90MP0001542_abnormal_bone_strength0.88881027
91MP0003938_abnormal_ear_development0.88590873
92MP0001286_abnormal_eye_development0.88016000
93MP0008775_abnormal_heart_ventricle0.87737405
94MP0005171_absent_coat_pigmentation0.87205784
95MP0002177_abnormal_outer_ear0.86552060
96MP0005193_abnormal_anterior_eye0.84370281
97MP0002896_abnormal_bone_mineralization0.83567442
98MP0003011_delayed_dark_adaptation0.83463033
99MP0002127_abnormal_cardiovascular_syste0.83165062
100MP0005408_hypopigmentation0.82407832
101MP0002877_abnormal_melanocyte_morpholog0.82305110
102MP0000678_abnormal_parathyroid_gland0.82000092
103MP0005076_abnormal_cell_differentiation0.81894009
104MP0005595_abnormal_vascular_smooth0.81105997
105MP0001243_abnormal_dermal_layer0.80962151
106MP0002796_impaired_skin_barrier0.80649262
107MP0002234_abnormal_pharynx_morphology0.80292660
108MP0001175_abnormal_lung_morphology0.78772657
109MP0002092_abnormal_eye_morphology0.77979354
110MP0001346_abnormal_lacrimal_gland0.77586397
111MP0005164_abnormal_response_to0.77531113
112MP0003119_abnormal_digestive_system0.76802585
113MP0002114_abnormal_axial_skeleton0.75893287
114MP0001915_intracranial_hemorrhage0.74527148
115MP0001299_abnormal_eye_distance/0.74240360
116MP0003453_abnormal_keratinocyte_physiol0.74209889
117MP0002925_abnormal_cardiovascular_devel0.73863822
118MP0005501_abnormal_skin_physiology0.73468618
119MP0002933_joint_inflammation0.73371769
120MP0003724_increased_susceptibility_to0.73285468
121MP0003136_yellow_coat_color0.71814560
122MP0008007_abnormal_cellular_replicative0.71511478
123MP0004197_abnormal_fetal_growth/weight/0.71258368
124MP0002837_dystrophic_cardiac_calcinosis0.70374114
125MP0004133_heterotaxia0.69300494
126MP0003693_abnormal_embryo_hatching0.68488619
127MP0000003_abnormal_adipose_tissue0.68356836
128MP0003878_abnormal_ear_physiology0.64676448
129MP0005377_hearing/vestibular/ear_phenot0.64676448
130MP0002089_abnormal_postnatal_growth/wei0.63648486
131MP0002084_abnormal_developmental_patter0.63572712
132MP0004019_abnormal_vitamin_homeostasis0.63485473
133MP0009780_abnormal_chondrocyte_physiolo0.61473844

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.95143165
2Premature rupture of membranes (HP:0001788)5.38077124
3Reticulocytopenia (HP:0001896)4.81363855
4Abnormality of cells of the erythroid lineage (HP:0012130)4.63893849
5Soft skin (HP:0000977)4.20334110
6Abnormal number of erythroid precursors (HP:0012131)4.05235943
7Macrocytic anemia (HP:0001972)4.00008333
8Bladder diverticulum (HP:0000015)3.73779233
9Follicular hyperkeratosis (HP:0007502)3.73338027
10Shallow orbits (HP:0000586)3.57084485
11Acute necrotizing encephalopathy (HP:0006965)3.48022005
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.44909275
13Neonatal short-limb short stature (HP:0008921)3.35288624
14Partial duplication of the phalanx of hand (HP:0009999)3.33542976
15Septo-optic dysplasia (HP:0100842)3.31566847
16Aortic dissection (HP:0002647)3.29059141
17Cerebral aneurysm (HP:0004944)3.21282941
18Partial duplication of thumb phalanx (HP:0009944)3.20380569
19Asymmetry of the thorax (HP:0001555)3.16644100
20Overgrowth (HP:0001548)3.04939819
21Biconcave vertebral bodies (HP:0004586)3.03585701
22Abnormal mitochondria in muscle tissue (HP:0008316)2.98654355
23Aortic aneurysm (HP:0004942)2.98150824
24Broad metatarsal (HP:0001783)2.90110373
25Vertebral compression fractures (HP:0002953)2.88948633
26Acute encephalopathy (HP:0006846)2.88217377
27Renal Fanconi syndrome (HP:0001994)2.85941761
28Congenital, generalized hypertrichosis (HP:0004540)2.83386195
29Mitochondrial inheritance (HP:0001427)2.77104515
30Concave nail (HP:0001598)2.72024090
31Increased hepatocellular lipid droplets (HP:0006565)2.70477214
32Abnormality of dentin (HP:0010299)2.68173332
33Progressive macrocephaly (HP:0004481)2.63233658
34Blue sclerae (HP:0000592)2.54886498
35Pallor (HP:0000980)2.49009045
36Poor head control (HP:0002421)2.49005746
37Coronal craniosynostosis (HP:0004440)2.48350609
38Type 1 muscle fiber predominance (HP:0003803)2.45137138
39Atrophic scars (HP:0001075)2.44593309
40Spinal rigidity (HP:0003306)2.43742962
41Nuclear cataract (HP:0100018)2.41919813
42Mitral valve prolapse (HP:0001634)2.37289350
43Increased connective tissue (HP:0009025)2.35289327
44Lipid accumulation in hepatocytes (HP:0006561)2.34672933
45Peritonitis (HP:0002586)2.30017937
46Ankle contracture (HP:0006466)2.29333295
47Limb-girdle muscle atrophy (HP:0003797)2.29220325
48Vascular tortuosity (HP:0004948)2.28693631
49Maternal diabetes (HP:0009800)2.28351706
50Buphthalmos (HP:0000557)2.27420159
51Hyperextensible skin (HP:0000974)2.26779224
52Wide anterior fontanel (HP:0000260)2.26331517
53Wormian bones (HP:0002645)2.24905020
54Delayed cranial suture closure (HP:0000270)2.22430911
55Exertional dyspnea (HP:0002875)2.21844268
56Elbow flexion contracture (HP:0002987)2.20334382
57Hypoplasia of the iris (HP:0007676)2.17157053
58Abnormal hemoglobin (HP:0011902)2.16923084
59Increased CSF lactate (HP:0002490)2.13945180
60Broad toe (HP:0001837)2.13340311
61Cerebral edema (HP:0002181)2.12970462
62Abnormality of liposaccharide metabolism (HP:0010968)2.09678321
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.09678321
64Abnormality of glycolipid metabolism (HP:0010969)2.09678321
65Lymphangioma (HP:0100764)2.07324800
66Hepatocellular necrosis (HP:0001404)2.05864226
67Arterial tortuosity (HP:0005116)2.02720276
68Cervical subluxation (HP:0003308)2.02351002
69Trismus (HP:0000211)2.01346495
70Absent septum pellucidum (HP:0001331)1.98980984
71Myocardial infarction (HP:0001658)1.98364078
72Stenosis of the external auditory canal (HP:0000402)1.97920326
73Short nail (HP:0001799)1.97796865
74Broad hallux (HP:0010055)1.97008646
75Rough bone trabeculation (HP:0100670)1.95177387
76Mesangial abnormality (HP:0001966)1.95075728
77Increased variability in muscle fiber diameter (HP:0003557)1.94381818
78Scapular winging (HP:0003691)1.93811292
79Porencephaly (HP:0002132)1.93222133
80Aneurysm (HP:0002617)1.92951203
81Knee flexion contracture (HP:0006380)1.92333846
82Abnormal delivery (HP:0001787)1.91330144
83Turricephaly (HP:0000262)1.90539211
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90106209
85Fragile skin (HP:0001030)1.86672150
86Abnormality of the hip-girdle musculature (HP:0001445)1.86427673
87Abnormality of the musculature of the pelvis (HP:0001469)1.86427673
88Osteopenia (HP:0000938)1.85818305
89Hepatic necrosis (HP:0002605)1.85799274
90Venous abnormality (HP:0002624)1.85213499
91Overriding aorta (HP:0002623)1.85117509
92Renal duplication (HP:0000075)1.84245538
93Exostoses (HP:0100777)1.82393728
94Abnormality of the parietal bone (HP:0002696)1.81779732
95Genu recurvatum (HP:0002816)1.81734217
96Dilatation of the ascending aorta (HP:0005111)1.81598621
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80737285
98Bronchomalacia (HP:0002780)1.80109054
99Nonimmune hydrops fetalis (HP:0001790)1.79839646
100Microglossia (HP:0000171)1.79533772
101Short hallux (HP:0010109)1.79494221
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79022704
103Rectal prolapse (HP:0002035)1.78846723
104Sparse eyelashes (HP:0000653)1.78844983
105Nasolacrimal duct obstruction (HP:0000579)1.78830538
106Abnormal number of incisors (HP:0011064)1.78273757
107Carpal synostosis (HP:0009702)1.78189769
108Nephritis (HP:0000123)1.77795595
109Selective tooth agenesis (HP:0001592)1.77228007
110Generalized amyotrophy (HP:0003700)1.77112975
111Joint stiffness (HP:0001387)1.76990495
112Venous insufficiency (HP:0005293)1.76200722
113Camptodactyly of toe (HP:0001836)1.76070242
114Achilles tendon contracture (HP:0001771)1.75583640
115Abnormality of skeletal muscle fiber size (HP:0012084)1.75374149
116Preaxial foot polydactyly (HP:0001841)1.74974637
117Hypophosphatemic rickets (HP:0004912)1.74759403
118Myelomeningocele (HP:0002475)1.74261097
119Absent eyelashes (HP:0000561)1.74122866
120Hip contracture (HP:0003273)1.73492641
121Congenital glaucoma (HP:0001087)1.73161850
122Ridged nail (HP:0001807)1.72799899
123Round ear (HP:0100830)1.72028876
124Hypoplastic ischia (HP:0003175)1.70642461
125Respiratory failure (HP:0002878)1.70296859
126Multiple enchondromatosis (HP:0005701)1.70033844
127Slender build (HP:0001533)1.69358565
128Duplication of thumb phalanx (HP:0009942)1.67717154
129Hypoplastic toenails (HP:0001800)1.66601375
130Abnormality of the Achilles tendon (HP:0005109)1.66355957
131Axonal loss (HP:0003447)1.66347676
132Abnormality of the acetabulum (HP:0003170)1.66039803
133Tarsal synostosis (HP:0008368)1.65812153
134Vertebral hypoplasia (HP:0008417)1.65494270
135Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.65494270
136Abnormality of renal resorption (HP:0011038)1.63352453
137Abnormality of the ischium (HP:0003174)1.63106795
138Wrist flexion contracture (HP:0001239)1.60165425
139Redundant skin (HP:0001582)1.60158931
140Deviation of the hallux (HP:0010051)1.59024116
141Abnormality of the calf musculature (HP:0001430)1.58960669
142Chondrocalcinosis (HP:0000934)1.57748690
143Abnormal trabecular bone morphology (HP:0100671)1.57619357
144Platyspondyly (HP:0000926)1.56851620
145Patent foramen ovale (HP:0001655)1.56715624
146Bowel diverticulosis (HP:0005222)1.56565928
147Natal tooth (HP:0000695)1.56534602
148Ectopia lentis (HP:0001083)1.56056773
149Hypoplastic left heart (HP:0004383)1.56035888
150Abnormality of the diencephalon (HP:0010662)1.55770452
151Megalencephaly (HP:0001355)1.55408305
152Testicular atrophy (HP:0000029)1.55335792
153Infantile muscular hypotonia (HP:0008947)1.55271661
154Synostosis of carpal bones (HP:0005048)1.55187647
155Hallux valgus (HP:0001822)1.55120564
156Deep venous thrombosis (HP:0002625)1.54667529
157Synostosis involving bones of the lower limbs (HP:0009138)1.54655929
158Synostosis involving bones of the feet (HP:0009140)1.54655929
159Thoracolumbar scoliosis (HP:0002944)1.54594430
160Calcaneovalgus deformity (HP:0001848)1.54395466
161Spondylolisthesis (HP:0003302)1.54249078
162Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.53074707
163Decreased activity of mitochondrial respiratory chain (HP:0008972)1.53074707
164Spinal cord compression (HP:0002176)1.52107373
165Deformed tarsal bones (HP:0008119)1.51933400
166Osteolytic defects of the hand bones (HP:0009699)1.50433001
167Osteolytic defects of the phalanges of the hand (HP:0009771)1.50433001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.84609653
2TLK14.76156897
3EPHB23.31511597
4TRIB33.15112715
5LATS23.13633934
6BUB12.47154296
7KDR2.26206519
8PKN22.25252473
9CDC72.21679800
10DDR22.14399235
11NME22.11317732
12MKNK22.06872738
13NEK92.05227281
14IRAK32.00054692
15ILK1.99965559
16RPS6KA41.98310341
17NEK11.97680739
18PIM21.93602905
19LRRK21.92582492
20PBK1.87972521
21BRSK21.87701406
22TAF11.86705203
23TESK11.80953314
24EIF2AK11.80397875
25PAK41.67744141
26PDGFRA1.67010762
27NTRK11.65184866
28MYLK1.57532949
29ERN11.57380205
30PTK2B1.53202531
31TTN1.51464408
32ERBB41.49999748
33PAK21.48916794
34MKNK11.45034549
35TIE11.44180285
36NME11.43927265
37CAMK1G1.43023657
38LIMK11.41481292
39TTK1.40725138
40TESK21.37436241
41FER1.36531023
42BMX1.35076891
43LATS11.31384213
44STK38L1.27438551
45DAPK31.25513080
46MAP3K121.22370902
47NEK21.19623096
48TNIK1.18329576
49PTK61.14513049
50DYRK31.13232344
51MAP2K21.08569184
52CDK71.08253610
53SRPK11.07098322
54FLT31.06755654
55PLK31.06732326
56TGFBR11.04535598
57AKT31.04306661
58VRK11.03859084
59TGFBR21.02937899
60PNCK1.02777447
61CDK81.02361776
62ROCK10.99773987
63SIK10.98622990
64MAP3K80.95995848
65BCKDK0.95139659
66DMPK0.89577981
67STK240.88230514
68PTK20.85944274
69PAK10.84512790
70MET0.83347334
71RPS6KA20.81371250
72MAPKAPK30.80458346
73MAP3K110.80047273
74MAP3K100.79348702
75RIPK10.78666992
76ADRBK20.78382412
77DYRK1B0.77171591
78RPS6KC10.76894645
79RPS6KL10.76894645
80CHEK20.75509890
81CAMKK20.74901293
82PLK10.74421751
83DYRK20.73723335
84TAOK20.72754243
85BRSK10.71526613
86ABL20.71472256
87RPS6KB20.71288673
88STK30.70757355
89BRAF0.69526224
90SMG10.69255662
91GRK10.69009678
92PRKG20.68553172
93MST40.68487563
94ARAF0.65335794
95RPS6KA60.64582421
96ROCK20.64341194
97PAK30.61713291
98FGFR10.60417650
99GRK70.57968502
100STK40.57887280
101LMTK20.56702024
102PRKD20.56667101
103AURKA0.54669671
104CSNK2A20.54453377
105CAMK1D0.53585203
106EPHA20.53551436
107AURKB0.52333396
108MST1R0.52196852
109PRKD10.52170719
110MUSK0.50696378
111MAP3K30.49102386
112EPHB10.47345921
113MTOR0.47250763
114CDC42BPA0.46162043
115IKBKB0.46061464
116CDK60.45279311
117MAP2K10.43103264
118ADRBK10.42992785
119PRKCE0.42977012
120OBSCN0.42372981
121PASK0.42293516
122PIK3CA0.41629238
123CSNK2A10.41591527
124EPHA30.40312614
125GSK3A0.40188851
126PIK3CG0.40061357
127ERBB20.39750531
128PRKCG0.38479010
129CDK90.38068888
130PRKCI0.37964269
131ALK0.37651468
132MOS0.36772015
133CSNK1E0.36738267
134CAMK2G0.35419698
135PRKAA20.34813883
136STK160.33839695
137PDK20.33136886
138STK100.32786453
139TBK10.32005768
140WEE10.31275376
141PRKD30.30878199
142PDGFRB0.30165898
143AKT20.29442542

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.19928688
2Ribosome_Homo sapiens_hsa030103.61167390
3ECM-receptor interaction_Homo sapiens_hsa045122.82049960
4Basal cell carcinoma_Homo sapiens_hsa052172.59947080
5Alzheimers disease_Homo sapiens_hsa050102.47022612
6Hedgehog signaling pathway_Homo sapiens_hsa043402.40374454
7Nitrogen metabolism_Homo sapiens_hsa009102.32960318
8Hippo signaling pathway_Homo sapiens_hsa043902.17723806
9Focal adhesion_Homo sapiens_hsa045102.02519466
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96548784
11Adherens junction_Homo sapiens_hsa045201.94946766
12Bladder cancer_Homo sapiens_hsa052191.94488648
13Proteoglycans in cancer_Homo sapiens_hsa052051.94263511
14Cardiac muscle contraction_Homo sapiens_hsa042601.87235223
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.83021864
16Sulfur relay system_Homo sapiens_hsa041221.77172269
17TGF-beta signaling pathway_Homo sapiens_hsa043501.76594911
18Small cell lung cancer_Homo sapiens_hsa052221.72646366
19Mismatch repair_Homo sapiens_hsa034301.70903993
20Proteasome_Homo sapiens_hsa030501.69878917
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61541384
22Malaria_Homo sapiens_hsa051441.60841676
23Amoebiasis_Homo sapiens_hsa051461.46369313
24MicroRNAs in cancer_Homo sapiens_hsa052061.43401450
25Thyroid cancer_Homo sapiens_hsa052161.38061940
26Protein digestion and absorption_Homo sapiens_hsa049741.37327565
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37051256
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36933867
29Complement and coagulation cascades_Homo sapiens_hsa046101.35589731
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35235509
31One carbon pool by folate_Homo sapiens_hsa006701.26217379
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.25589679
33RNA polymerase_Homo sapiens_hsa030201.23821671
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22546988
35RNA transport_Homo sapiens_hsa030131.19143287
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19018233
37HTLV-I infection_Homo sapiens_hsa051661.18112279
38Cell cycle_Homo sapiens_hsa041101.15122692
39Pyruvate metabolism_Homo sapiens_hsa006201.13999796
40Notch signaling pathway_Homo sapiens_hsa043301.13321284
41Spliceosome_Homo sapiens_hsa030401.13183674
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11010810
43Nucleotide excision repair_Homo sapiens_hsa034201.10081328
44Dilated cardiomyopathy_Homo sapiens_hsa054141.08203801
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.06397821
46Melanogenesis_Homo sapiens_hsa049161.05893097
47Melanoma_Homo sapiens_hsa052181.04449286
48* Tight junction_Homo sapiens_hsa045301.03298510
49Pathways in cancer_Homo sapiens_hsa052001.03157364
50Basal transcription factors_Homo sapiens_hsa030220.99923552
51Tryptophan metabolism_Homo sapiens_hsa003800.99561136
52Prostate cancer_Homo sapiens_hsa052150.99558343
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98394871
54Fatty acid elongation_Homo sapiens_hsa000620.96457349
55Mineral absorption_Homo sapiens_hsa049780.95930611
56p53 signaling pathway_Homo sapiens_hsa041150.94116714
57Viral myocarditis_Homo sapiens_hsa054160.94051894
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91101227
59Glutathione metabolism_Homo sapiens_hsa004800.89748969
60Chemical carcinogenesis_Homo sapiens_hsa052040.89705368
61Lysosome_Homo sapiens_hsa041420.89553656
62Other glycan degradation_Homo sapiens_hsa005110.89389173
63Chronic myeloid leukemia_Homo sapiens_hsa052200.89201972
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85919314
65Fatty acid degradation_Homo sapiens_hsa000710.85001411
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.84647463
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81146305
68Arginine biosynthesis_Homo sapiens_hsa002200.81113799
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77507227
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.76151741
71Wnt signaling pathway_Homo sapiens_hsa043100.75946621
72PPAR signaling pathway_Homo sapiens_hsa033200.75921877
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75625973
74Vibrio cholerae infection_Homo sapiens_hsa051100.74993035
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74200415
76HIF-1 signaling pathway_Homo sapiens_hsa040660.73363782
77Purine metabolism_Homo sapiens_hsa002300.73187076
78Metabolic pathways_Homo sapiens_hsa011000.73177390
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.72546464
80Selenocompound metabolism_Homo sapiens_hsa004500.72520695
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71436871
82Tyrosine metabolism_Homo sapiens_hsa003500.70925002
83Protein export_Homo sapiens_hsa030600.70583163
84Homologous recombination_Homo sapiens_hsa034400.68163916
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67868422
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66962854
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66590076
88Prion diseases_Homo sapiens_hsa050200.66389440
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65976384
90Folate biosynthesis_Homo sapiens_hsa007900.65380259
91Arginine and proline metabolism_Homo sapiens_hsa003300.64335949
92RNA degradation_Homo sapiens_hsa030180.63866022
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.63175439
94Vitamin B6 metabolism_Homo sapiens_hsa007500.62283247
95Galactose metabolism_Homo sapiens_hsa000520.61975674
96Pentose phosphate pathway_Homo sapiens_hsa000300.61793889
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.60838351
98Renal cell carcinoma_Homo sapiens_hsa052110.60326417
99N-Glycan biosynthesis_Homo sapiens_hsa005100.59741125
100Carbon metabolism_Homo sapiens_hsa012000.59261531
101Biosynthesis of amino acids_Homo sapiens_hsa012300.58884024
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56061314
103Huntingtons disease_Homo sapiens_hsa050160.56000047
104Retinol metabolism_Homo sapiens_hsa008300.55294576
105DNA replication_Homo sapiens_hsa030300.54619672
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52475009
107Fructose and mannose metabolism_Homo sapiens_hsa000510.51171673
108Parkinsons disease_Homo sapiens_hsa050120.50511410
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49673441
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49560863
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48704676
112Staphylococcus aureus infection_Homo sapiens_hsa051500.48318491
113Apoptosis_Homo sapiens_hsa042100.47962997
114TNF signaling pathway_Homo sapiens_hsa046680.47748828
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46933516
116mRNA surveillance pathway_Homo sapiens_hsa030150.46190271
117Base excision repair_Homo sapiens_hsa034100.45920706
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45825978
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44114503
120African trypanosomiasis_Homo sapiens_hsa051430.44069394
121Sulfur metabolism_Homo sapiens_hsa009200.43752962
122Rap1 signaling pathway_Homo sapiens_hsa040150.43029713
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42977209
124beta-Alanine metabolism_Homo sapiens_hsa004100.41790838
125Lysine degradation_Homo sapiens_hsa003100.41588342
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41575663
127Collecting duct acid secretion_Homo sapiens_hsa049660.41359742
128Glioma_Homo sapiens_hsa052140.39083287
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38689373
130Acute myeloid leukemia_Homo sapiens_hsa052210.38554492
131Pyrimidine metabolism_Homo sapiens_hsa002400.38428139
132Starch and sucrose metabolism_Homo sapiens_hsa005000.37778646
133Viral carcinogenesis_Homo sapiens_hsa052030.37465140
134Vitamin digestion and absorption_Homo sapiens_hsa049770.37355483
135Hepatitis B_Homo sapiens_hsa051610.37148403
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36272655

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