RAB14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.26453313
2desmosome organization (GO:0002934)4.10153031
3neuron cell-cell adhesion (GO:0007158)3.94480366
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.79665517
5regulation of synaptic vesicle exocytosis (GO:2000300)3.77707129
6synaptic vesicle maturation (GO:0016188)3.65364874
7protein localization to endosome (GO:0036010)3.63385698
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61411640
9vocalization behavior (GO:0071625)3.58949996
10protein localization to synapse (GO:0035418)3.55850931
11neuronal action potential propagation (GO:0019227)3.55639477
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.47360000
13glutamate secretion (GO:0014047)3.44909608
14pyrimidine nucleobase catabolic process (GO:0006208)3.44605403
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43127732
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.41910961
17neuron recognition (GO:0008038)3.40275410
18regulation of synaptic vesicle transport (GO:1902803)3.31259628
19localization within membrane (GO:0051668)3.26840087
20glutamate receptor signaling pathway (GO:0007215)3.23049686
21sodium ion export (GO:0071436)3.21932294
22regulation of vesicle fusion (GO:0031338)3.20510265
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20288697
24COPII vesicle coating (GO:0048208)3.20252130
25regulation of glutamate receptor signaling pathway (GO:1900449)3.16447972
26presynaptic membrane assembly (GO:0097105)3.13245618
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.12042153
28COPI coating of Golgi vesicle (GO:0048205)3.06685121
29Golgi transport vesicle coating (GO:0048200)3.06685121
30negative regulation of neurotransmitter transport (GO:0051589)3.03058330
31regulation of neuronal synaptic plasticity (GO:0048168)3.01269492
32vesicle transport along microtubule (GO:0047496)2.98120930
33synaptic vesicle endocytosis (GO:0048488)2.97763590
34neurotransmitter secretion (GO:0007269)2.97629183
35exploration behavior (GO:0035640)2.95355304
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93689282
37axonal fasciculation (GO:0007413)2.92998333
38layer formation in cerebral cortex (GO:0021819)2.92142589
39righting reflex (GO:0060013)2.91676824
40locomotory exploration behavior (GO:0035641)2.87344143
41positive regulation of vesicle fusion (GO:0031340)2.86896529
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86188778
43ether lipid metabolic process (GO:0046485)2.85538065
44dendritic spine morphogenesis (GO:0060997)2.83537224
45presynaptic membrane organization (GO:0097090)2.81261533
46keratinocyte development (GO:0003334)2.81156484
47cell communication by electrical coupling (GO:0010644)2.76055074
48postsynaptic membrane organization (GO:0001941)2.75489915
49regulation of synapse structural plasticity (GO:0051823)2.74879754
50dendrite morphogenesis (GO:0048813)2.74166463
51neuron-neuron synaptic transmission (GO:0007270)2.71414892
52transmission of nerve impulse (GO:0019226)2.69688481
53vesicle coating (GO:0006901)2.69677522
54synaptic transmission, glutamatergic (GO:0035249)2.69306840
55regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69206915
56organelle transport along microtubule (GO:0072384)2.68543908
57synaptic vesicle transport (GO:0048489)2.68248720
58establishment of synaptic vesicle localization (GO:0097480)2.68248720
59regulation of dendritic spine morphogenesis (GO:0061001)2.68094224
60cellular potassium ion homeostasis (GO:0030007)2.66593392
61regulation of early endosome to late endosome transport (GO:2000641)2.64683673
62proline transport (GO:0015824)2.64625780
63negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63490121
64neuron remodeling (GO:0016322)2.61844736
65gamma-aminobutyric acid transport (GO:0015812)2.56013173
66regulation of postsynaptic membrane potential (GO:0060078)2.55297142
67establishment of vesicle localization (GO:0051650)2.55110100
68regulation of dendritic spine development (GO:0060998)2.54083572
69mating behavior (GO:0007617)2.54032323
70endothelium development (GO:0003158)2.51784755
71neurotransmitter transport (GO:0006836)2.51775249
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51264853
73negative regulation of neurotransmitter secretion (GO:0046929)2.50781574
74import into cell (GO:0098657)2.50183713
75regulation of glomerular filtration (GO:0003093)2.49981663
76detection of calcium ion (GO:0005513)2.47172022
77neurotransmitter-gated ion channel clustering (GO:0072578)2.46996136
78long-term synaptic potentiation (GO:0060291)2.46902575
79L-serine transport (GO:0015825)2.45523463
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.44490572
81cerebellar granule cell differentiation (GO:0021707)2.42470922
82keratinocyte proliferation (GO:0043616)2.42175062
83synapse assembly (GO:0007416)2.41910008
84regulation of synaptic transmission, glutamatergic (GO:0051966)2.41517084
85regulation of synaptic plasticity (GO:0048167)2.41153309
86cerebral cortex radially oriented cell migration (GO:0021799)2.40393828
87membrane budding (GO:0006900)2.40221088
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39062817
89long-term memory (GO:0007616)2.38106274
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38042099
91regulation of water loss via skin (GO:0033561)2.37790635
92innervation (GO:0060384)2.36997938
93calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.36752642
94positive regulation of membrane potential (GO:0045838)2.36557839
95regulation of neurotransmitter secretion (GO:0046928)2.36018659
96regulation of neurotransmitter levels (GO:0001505)2.34992118
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.34360965
98peptidyl-cysteine modification (GO:0018198)2.33758879
99renal system process involved in regulation of blood volume (GO:0001977)2.32817557
100nerve growth factor signaling pathway (GO:0038180)2.32146681
101regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.31796269
102mechanosensory behavior (GO:0007638)2.31243668
103response to nerve growth factor (GO:1990089)2.30892103
104cellular response to nerve growth factor stimulus (GO:1990090)2.30892103
105adult walking behavior (GO:0007628)2.30772140
106long-chain fatty acid biosynthetic process (GO:0042759)2.30527316
107cellular sodium ion homeostasis (GO:0006883)2.29953470
108establishment of skin barrier (GO:0061436)2.29782260
109regulation of amyloid precursor protein catabolic process (GO:1902991)2.29690621
110dopamine biosynthetic process (GO:0042416)2.29012166
111regulation of protein glycosylation (GO:0060049)2.28427458
112positive regulation of exocytosis (GO:0045921)2.28174380
113cellular response to glucagon stimulus (GO:0071377)2.28040939
114regulation of clathrin-mediated endocytosis (GO:2000369)2.27785661
115endoplasmic reticulum organization (GO:0007029)2.27330148
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26852097
117dendritic spine organization (GO:0097061)2.26821229
118behavioral response to cocaine (GO:0048148)2.26499990
119regulation of glutamate secretion (GO:0014048)2.26146557
120dendrite development (GO:0016358)2.26075353
121auditory behavior (GO:0031223)2.25649034
122positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.25543449
123mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.25543449
124learning (GO:0007612)2.25194785
125activation of protein kinase A activity (GO:0034199)2.24551236
126startle response (GO:0001964)2.24495917
127synaptic vesicle docking involved in exocytosis (GO:0016081)2.24360887
128positive regulation of amino acid transport (GO:0051957)2.23940029
129response to auditory stimulus (GO:0010996)2.23796737
130clathrin coat assembly (GO:0048268)2.23548425
131negative regulation of protein localization to plasma membrane (GO:1903077)2.23518513
132regulation of exocytosis (GO:0017157)2.23042134
133Golgi to plasma membrane protein transport (GO:0043001)2.22583218
134behavioral defense response (GO:0002209)2.21066853
135behavioral fear response (GO:0001662)2.21066853
136cerebral cortex cell migration (GO:0021795)2.20833905
137nucleobase catabolic process (GO:0046113)2.20209757
138response to histamine (GO:0034776)2.19905897
139synapse organization (GO:0050808)2.19571730
140regulation of ARF protein signal transduction (GO:0032012)2.19378147
141protein localization to microtubule (GO:0035372)2.19086327
142intestinal epithelial cell development (GO:0060576)2.19041383
143photoreceptor cell differentiation (GO:0046530)2.18670489
144eye photoreceptor cell differentiation (GO:0001754)2.18670489
145transferrin transport (GO:0033572)2.17521138
146cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.17419810
147Rap protein signal transduction (GO:0032486)2.16868098
148adenine nucleotide transport (GO:0051503)2.15897111
149skin morphogenesis (GO:0043589)2.15331459
150serine transport (GO:0032329)2.15018586
151cell migration in hindbrain (GO:0021535)2.14286332
152response to dietary excess (GO:0002021)2.14060195
153suckling behavior (GO:0001967)2.12347539
154regulation of cholesterol homeostasis (GO:2000188)2.11607979
155negative regulation of dendrite morphogenesis (GO:0050774)2.11603498
156regulation of transforming growth factor beta1 production (GO:0032908)2.11284516
157potassium ion homeostasis (GO:0055075)2.09942489
158retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.09487041
159trivalent inorganic cation transport (GO:0072512)2.09162756
160ferric iron transport (GO:0015682)2.09162756
161positive regulation of transforming growth factor beta production (GO:0071636)2.07455632
162polyol transport (GO:0015791)2.07311306
163purine nucleotide transport (GO:0015865)2.06620365
164cell communication involved in cardiac conduction (GO:0086065)2.05719031
165epoxygenase P450 pathway (GO:0019373)2.05039296
166negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.04115663
167regulation of Rac protein signal transduction (GO:0035020)2.03905094
168positive regulation of insulin receptor signaling pathway (GO:0046628)2.02338811
169cellular copper ion homeostasis (GO:0006878)2.01504988
170glutamate metabolic process (GO:0006536)2.00368766
171central nervous system projection neuron axonogenesis (GO:0021952)2.00280948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.57860135
2GBX2_23144817_ChIP-Seq_PC3_Human3.30228277
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59461109
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.56894811
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51456746
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49225769
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29373902
8TAF15_26573619_Chip-Seq_HEK293_Human2.27966037
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21754310
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20449931
11CLOCK_20551151_ChIP-Seq_293T_Human2.20022704
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17336317
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16730666
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16730666
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12401747
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11229732
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09045116
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04754496
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.01825049
20IGF1R_20145208_ChIP-Seq_DFB_Human1.96083940
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93472580
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92486457
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.92115476
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90487574
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90346650
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89763458
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87967891
28AR_21572438_ChIP-Seq_LNCaP_Human1.87764642
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85204250
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83865734
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.82277411
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81081127
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.77895351
34P300_19829295_ChIP-Seq_ESCs_Human1.76232624
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76084791
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.75028588
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71587552
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71108135
39REST_21632747_ChIP-Seq_MESCs_Mouse1.70636132
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.70466513
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.70299076
42SMAD4_21799915_ChIP-Seq_A2780_Human1.67458963
43VDR_22108803_ChIP-Seq_LS180_Human1.66803409
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63845525
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60198283
46SOX2_20726797_ChIP-Seq_SW620_Human1.58910144
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57874169
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53544406
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.51303559
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47302267
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45741385
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45690252
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45196376
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45180969
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.44327692
56DROSHA_22980978_ChIP-Seq_HELA_Human1.44167231
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43505202
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43428155
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43364740
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43364740
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42684072
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.41986458
63AR_25329375_ChIP-Seq_VCAP_Human1.40806449
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40643867
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39194559
66FUS_26573619_Chip-Seq_HEK293_Human1.38858552
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.37989412
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36042139
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36011412
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34949201
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34410393
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31042152
73TP53_18474530_ChIP-ChIP_U2OS_Human1.30543418
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28355240
75ER_23166858_ChIP-Seq_MCF-7_Human1.28257208
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28008992
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27760382
78STAT3_23295773_ChIP-Seq_U87_Human1.26428324
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25919799
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.25321830
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.25282440
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24502975
83TP53_16413492_ChIP-PET_HCT116_Human1.23876947
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.23871971
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.23106626
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.21101743
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20906211
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19879833
89* TP63_23658742_ChIP-Seq_EP156T_Human1.18864121
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18793940
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.18231477
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15250418
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15222111
94* NANOG_18555785_Chip-Seq_ESCs_Mouse1.14555902
95* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13783133
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13353546
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12845303
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12145018
99RUNX2_22187159_ChIP-Seq_PCA_Human1.11165773
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11095513
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10624169
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10624169
103AHR_22903824_ChIP-Seq_MCF-7_Human1.09547073
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09486218
105RNF2_27304074_Chip-Seq_NSC_Mouse1.09257305
106BCAT_22108803_ChIP-Seq_LS180_Human1.09043820
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08741138
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.08343194
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08032073
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07244924
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.07199154
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06649800
113TCF4_23295773_ChIP-Seq_U87_Human1.05457979
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.04963610
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03935918
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03896115
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03464238
118ESR1_21235772_ChIP-Seq_MCF-7_Human1.02780139
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.02197218
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00234095
121FOXA1_25552417_ChIP-Seq_VCAP_Human1.00062213
122CJUN_26792858_Chip-Seq_BT549_Human0.99837743
123* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99737039
124BP1_19119308_ChIP-ChIP_Hs578T_Human0.98811306
125JUN_21703547_ChIP-Seq_K562_Human0.98686986
126* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98249023
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98181394
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97923788
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97235106
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97220773
131KDM2B_26808549_Chip-Seq_REH_Human0.96620414
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95165919
133* P53_22387025_ChIP-Seq_ESCs_Mouse0.94793739
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94344582
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94169224
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.94126235
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93235412
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.93168715
139* CMYC_18555785_Chip-Seq_ESCs_Mouse0.93136919
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93115718
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92521162
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.92492983
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.92202846
144SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91895365
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91751841
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.91526665
147ZNF274_21170338_ChIP-Seq_K562_Hela0.91302450
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90437531
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90132037
150* AR_19668381_ChIP-Seq_PC3_Human0.89989466
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87955217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.81572572
2MP0003880_abnormal_central_pattern4.63553461
3MP0002796_impaired_skin_barrier3.54721376
4MP0004270_analgesia3.48971829
5MP0003635_abnormal_synaptic_transmissio3.44824656
6MP0009745_abnormal_behavioral_response2.83486535
7MP0002063_abnormal_learning/memory/cond2.82216684
8MP0002064_seizures2.74895596
9MP0003329_amyloid_beta_deposits2.45321131
10MP0002572_abnormal_emotion/affect_behav2.42208216
11MP0010678_abnormal_skin_adnexa2.37546293
12MP0009780_abnormal_chondrocyte_physiolo2.36357300
13MP0001968_abnormal_touch/_nociception2.31745501
14MP0009046_muscle_twitch2.30676997
15MP0001486_abnormal_startle_reflex2.28742411
16MP0006276_abnormal_autonomic_nervous2.25309801
17MP0002734_abnormal_mechanical_nocicepti2.24423105
18MP0002272_abnormal_nervous_system2.24040883
19MP0001501_abnormal_sleep_pattern2.09030271
20MP0002733_abnormal_thermal_nociception2.00091355
21MP0005275_abnormal_skin_tensile1.99211663
22MP0000778_abnormal_nervous_system1.97451193
23MP0000920_abnormal_myelination1.96702109
24MP0005501_abnormal_skin_physiology1.85784639
25MP0005423_abnormal_somatic_nervous1.81195597
26MP0001984_abnormal_olfaction1.78465298
27MP0002735_abnormal_chemical_nociception1.76889233
28MP0001970_abnormal_pain_threshold1.76302084
29MP0002736_abnormal_nociception_after1.75183753
30MP0002067_abnormal_sensory_capabilities1.75132674
31MP0001529_abnormal_vocalization1.71296348
32MP0001440_abnormal_grooming_behavior1.71088929
33MP0000604_amyloidosis1.68802225
34MP0004924_abnormal_behavior1.66273917
35MP0005386_behavior/neurological_phenoty1.66273917
36MP0004782_abnormal_surfactant_physiolog1.63839067
37MP0002184_abnormal_innervation1.61498690
38MP0001905_abnormal_dopamine_level1.61031023
39MP0003453_abnormal_keratinocyte_physiol1.56270277
40MP0003300_gastrointestinal_ulcer1.56023884
41MP0010386_abnormal_urinary_bladder1.53991927
42MP0008569_lethality_at_weaning1.53319666
43MP0005248_abnormal_Harderian_gland1.52054792
44MP0002909_abnormal_adrenal_gland1.50025049
45MP0002557_abnormal_social/conspecific_i1.49366683
46MP0003183_abnormal_peptide_metabolism1.49095615
47MP0002009_preneoplasia1.48467228
48MP0000462_abnormal_digestive_system1.44799994
49MP0004885_abnormal_endolymph1.44331922
50MP0003191_abnormal_cellular_cholesterol1.42699345
51MP0001216_abnormal_epidermal_layer1.39490378
52MP0000383_abnormal_hair_follicle1.35836666
53MP0002139_abnormal_hepatobiliary_system1.34962807
54MP0003690_abnormal_glial_cell1.34427046
55MP0000955_abnormal_spinal_cord1.32947595
56MP0003633_abnormal_nervous_system1.30618297
57MP0005645_abnormal_hypothalamus_physiol1.29739948
58MP0002896_abnormal_bone_mineralization1.29730826
59MP0003879_abnormal_hair_cell1.28041113
60MP0001502_abnormal_circadian_rhythm1.27948877
61MP0002837_dystrophic_cardiac_calcinosis1.27134531
62MP0002882_abnormal_neuron_morphology1.22983693
63MP0005409_darkened_coat_color1.21876311
64MP0005379_endocrine/exocrine_gland_phen1.21411433
65MP0001188_hyperpigmentation1.20711276
66MP0002066_abnormal_motor_capabilities/c1.20197385
67MP0004811_abnormal_neuron_physiology1.17594041
68MP0003634_abnormal_glial_cell1.17005208
69MP0003868_abnormal_feces_composition1.14136417
70MP0003279_aneurysm1.12251516
71MP0003631_nervous_system_phenotype1.11761489
72MP0005646_abnormal_pituitary_gland1.09729624
73MP0002877_abnormal_melanocyte_morpholog1.09675529
74MP0001542_abnormal_bone_strength1.09387043
75MP0005535_abnormal_body_temperature1.08984698
76MP0002822_catalepsy1.07423518
77MP0003787_abnormal_imprinting1.06955823
78MP0001177_atelectasis1.06055418
79MP0002229_neurodegeneration1.05922670
80MP0010771_integument_phenotype1.05314019
81MP0000427_abnormal_hair_cycle1.04189163
82MP0004142_abnormal_muscle_tone1.03916671
83MP0003091_abnormal_cell_migration1.00911049
84MP0002098_abnormal_vibrissa_morphology1.00907313
85MP0004264_abnormal_extraembryonic_tissu1.00103952
86MP0010234_abnormal_vibrissa_follicle0.99481281
87MP0008260_abnormal_autophagy0.97436307
88MP0005084_abnormal_gallbladder_morpholo0.97279715
89MP0004742_abnormal_vestibular_system0.96607664
90MP0005623_abnormal_meninges_morphology0.96381951
91MP0000631_abnormal_neuroendocrine_gland0.96185195
92MP0002090_abnormal_vision0.95658568
93MP0000647_abnormal_sebaceous_gland0.95650043
94MP0000013_abnormal_adipose_tissue0.95203948
95MP0004858_abnormal_nervous_system0.94766331
96MP0008438_abnormal_cutaneous_collagen0.94137567
97MP0000569_abnormal_digit_pigmentation0.93732824
98MP0000377_abnormal_hair_follicle0.92721891
99MP0005551_abnormal_eye_electrophysiolog0.92418553
100MP0001191_abnormal_skin_condition0.91793651
101MP0003075_altered_response_to0.91142280
102MP0002876_abnormal_thyroid_physiology0.89760255
103MP0003172_abnormal_lysosome_physiology0.88854265
104MP0004510_myositis0.88226425
105MP0005174_abnormal_tail_pigmentation0.88122233
106MP0003632_abnormal_nervous_system0.87897673
107MP0000465_gastrointestinal_hemorrhage0.87880768
108MP0002060_abnormal_skin_morphology0.87049683
109MP0005171_absent_coat_pigmentation0.87005070
110MP0003283_abnormal_digestive_organ0.85155951
111MP0005388_respiratory_system_phenotype0.84515292
112MP0002133_abnormal_respiratory_system0.84515292
113MP0000566_synostosis0.84444842
114MP0010329_abnormal_lipoprotein_level0.84262943
115MP0001879_abnormal_lymphatic_vessel0.82353206
116MP0004883_abnormal_blood_vessel0.81964671
117MP0000015_abnormal_ear_pigmentation0.81922052
118MP0001270_distended_abdomen0.81648569
119MP0003123_paternal_imprinting0.80929685
120MP0004130_abnormal_muscle_cell0.80606843
121MP0003828_pulmonary_edema0.79520360
122MP0003195_calcinosis0.79232984
123MP0002069_abnormal_eating/drinking_beha0.79178272
124MP0005365_abnormal_bile_salt0.78796715
125MP0002152_abnormal_brain_morphology0.78109481
126MP0003566_abnormal_cell_adhesion0.77813922
127MP0001963_abnormal_hearing_physiology0.76732077
128MP0004484_altered_response_of0.76697285
129MP0010352_gastrointestinal_tract_polyps0.76287390
130MP0005085_abnormal_gallbladder_physiolo0.76050498
131MP0003122_maternal_imprinting0.75430191
132MP0000639_abnormal_adrenal_gland0.74776687
133MP0004043_abnormal_pH_regulation0.74525830
134MP0001485_abnormal_pinna_reflex0.71752273
135MP0006054_spinal_hemorrhage0.70223488
136MP0008874_decreased_physiological_sensi0.69985424
137MP0010368_abnormal_lymphatic_system0.68819272
138MP0000681_abnormal_thyroid_gland0.68341399
139MP0002163_abnormal_gland_morphology0.66287979
140MP0002971_abnormal_brown_adipose0.64835023
141MP0005058_abnormal_lysosome_morphology0.63671923
142MP0005595_abnormal_vascular_smooth0.63464716
143MP0004085_abnormal_heartbeat0.63006647
144MP0000230_abnormal_systemic_arterial0.62604992
145MP0005408_hypopigmentation0.60298043
146MP0002752_abnormal_somatic_nervous0.59995670
147MP0001851_eye_inflammation0.59133135
148MP0004215_abnormal_myocardial_fiber0.57260160
149MP0002295_abnormal_pulmonary_circulatio0.53856944
150MP0002693_abnormal_pancreas_physiology0.53407377
151MP0008875_abnormal_xenobiotic_pharmacok0.53381253

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.53879722
2Neurofibrillary tangles (HP:0002185)5.02803816
3Visual hallucinations (HP:0002367)4.26362442
4Cerebral inclusion bodies (HP:0100314)4.23574162
5Supranuclear gaze palsy (HP:0000605)4.15755064
6Focal seizures (HP:0007359)3.91060773
7Atonic seizures (HP:0010819)3.82749093
8Epileptic encephalopathy (HP:0200134)3.79509537
9Myokymia (HP:0002411)3.72190429
10Progressive inability to walk (HP:0002505)3.49396874
11Action tremor (HP:0002345)3.39803103
12Absence seizures (HP:0002121)3.37713015
13Curly hair (HP:0002212)3.30761189
14Generalized tonic-clonic seizures (HP:0002069)3.27778339
15Hyperventilation (HP:0002883)3.27487399
16Aplasia involving bones of the upper limbs (HP:0009823)3.21194800
17Aplasia of the phalanges of the hand (HP:0009802)3.21194800
18Aplasia involving bones of the extremities (HP:0009825)3.21194800
19Tetraparesis (HP:0002273)3.17485398
20Progressive cerebellar ataxia (HP:0002073)3.13993394
21Papillary thyroid carcinoma (HP:0002895)3.08132076
22Dialeptic seizures (HP:0011146)3.08055322
23Excessive salivation (HP:0003781)2.99372048
24Drooling (HP:0002307)2.99372048
25Ankle clonus (HP:0011448)2.98826878
26Febrile seizures (HP:0002373)2.95245545
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.92134694
28Mutism (HP:0002300)2.87378280
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.86435128
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.86435128
31Papilledema (HP:0001085)2.82892101
32Truncal ataxia (HP:0002078)2.76938948
33Termporal pattern (HP:0011008)2.74431377
34Insidious onset (HP:0003587)2.74431377
35Generalized hypopigmentation of hair (HP:0011358)2.72023754
36Agitation (HP:0000713)2.71908330
37Anxiety (HP:0000739)2.70499969
38Broad-based gait (HP:0002136)2.67909809
39Dysmetria (HP:0001310)2.67853562
40Generalized myoclonic seizures (HP:0002123)2.66419023
41Abnormality of the corticospinal tract (HP:0002492)2.65640338
42Scanning speech (HP:0002168)2.61284027
43Increased cerebral lipofuscin (HP:0011813)2.59188240
44Poor eye contact (HP:0000817)2.58900430
45Absent speech (HP:0001344)2.56950777
46Intention tremor (HP:0002080)2.55949142
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.54974935
48Arterial tortuosity (HP:0005116)2.52737521
49Cerebral hemorrhage (HP:0001342)2.52406103
50Growth hormone excess (HP:0000845)2.50038509
51Inappropriate behavior (HP:0000719)2.46020124
52Retinal dysplasia (HP:0007973)2.41911983
53Spastic gait (HP:0002064)2.41348656
54Limb dystonia (HP:0002451)2.39077854
55Exotropia (HP:0000577)2.34079913
56Protruding tongue (HP:0010808)2.33749654
57Impaired social interactions (HP:0000735)2.31632208
58Abnormal social behavior (HP:0012433)2.31632208
59Thyroid carcinoma (HP:0002890)2.30311775
60Blue irides (HP:0000635)2.29847654
61Hypothermia (HP:0002045)2.28038840
62Pheochromocytoma (HP:0002666)2.27122509
63Alopecia of scalp (HP:0002293)2.26190521
64Atrioventricular block (HP:0001678)2.24936298
65Depression (HP:0000716)2.24210520
66Widely spaced teeth (HP:0000687)2.24062049
67Epileptiform EEG discharges (HP:0011182)2.23988206
68Dysdiadochokinesis (HP:0002075)2.22659842
69Polyphagia (HP:0002591)2.22616434
70Inability to walk (HP:0002540)2.22230608
71Vascular tortuosity (HP:0004948)2.21677061
72Mitral stenosis (HP:0001718)2.21176383
73Akinesia (HP:0002304)2.19936460
74Abnormality of salivation (HP:0100755)2.18785251
75Spinal cord lesions (HP:0100561)2.17603767
76Syringomyelia (HP:0003396)2.17603767
77Lower limb muscle weakness (HP:0007340)2.16998637
78EEG with generalized epileptiform discharges (HP:0011198)2.16462092
79Abnormality of calcium-phosphate metabolism (HP:0100530)2.12764476
80Torticollis (HP:0000473)2.12119906
81Neuroendocrine neoplasm (HP:0100634)2.11311264
82Palmoplantar hyperkeratosis (HP:0000972)2.06717787
83Clumsiness (HP:0002312)2.06196069
84Diplopia (HP:0000651)2.06063931
85Abnormality of binocular vision (HP:0011514)2.06063931
86Neoplasm of the heart (HP:0100544)2.04998773
87Urinary bladder sphincter dysfunction (HP:0002839)2.04878346
88Fair hair (HP:0002286)2.03712688
89Disinhibition (HP:0000734)2.01834561
90Menstrual irregularities (HP:0000858)2.01713068
91Impaired vibration sensation in the lower limbs (HP:0002166)2.01468961
92Hypsarrhythmia (HP:0002521)2.00598823
93Palmar hyperkeratosis (HP:0010765)2.00582569
94Abnormal eating behavior (HP:0100738)2.00417368
95Thickened helices (HP:0000391)1.99726875
96Postural tremor (HP:0002174)1.99362509
97Generalized hypopigmentation (HP:0007513)1.98155844
98Psychosis (HP:0000709)1.97660833
99Neuronal loss in central nervous system (HP:0002529)1.96697545
100Conjunctival hamartoma (HP:0100780)1.95446350
101Open mouth (HP:0000194)1.94580613
102Gaze-evoked nystagmus (HP:0000640)1.94310667
103Metaphyseal dysplasia (HP:0100255)1.94013976
104Amblyopia (HP:0000646)1.90666287
105Apathy (HP:0000741)1.89894029
106Onion bulb formation (HP:0003383)1.89156001
107Cubitus valgus (HP:0002967)1.88490709
108Plantar hyperkeratosis (HP:0007556)1.88273388
109Focal dystonia (HP:0004373)1.86824683
110Megalencephaly (HP:0001355)1.86795924
111Striae distensae (HP:0001065)1.86666807
112Fetal akinesia sequence (HP:0001989)1.86482771
113Axonal loss (HP:0003447)1.86320539
114White forelock (HP:0002211)1.84808591
115Urinary urgency (HP:0000012)1.84753290
116Split foot (HP:0001839)1.84339698
117Abnormality of the dental root (HP:0006486)1.84063003
118Taurodontia (HP:0000679)1.84063003
119Abnormality of permanent molar morphology (HP:0011071)1.84063003
120Hemiparesis (HP:0001269)1.83847761
121Stereotypic behavior (HP:0000733)1.83284492
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82970790
123Abnormality of molar (HP:0011077)1.80172123
124Abnormality of molar morphology (HP:0011070)1.80172123
125Patchy hypopigmentation of hair (HP:0011365)1.80076428
126Abnormal hair whorl (HP:0010721)1.80003218
127Hypotrichosis (HP:0001006)1.76946927
128Hypoplasia of dental enamel (HP:0006297)1.76764895
129Abnormal atrioventricular conduction (HP:0005150)1.76744065
130Parakeratosis (HP:0001036)1.76401240
131Thick nail (HP:0001805)1.75095022
132Heart block (HP:0012722)1.74461807
133Dysostosis multiplex (HP:0000943)1.74282319
134Diminished motivation (HP:0000745)1.74217302
135Rapidly progressive (HP:0003678)1.73896967
136Postural instability (HP:0002172)1.72593108
137Sleep apnea (HP:0010535)1.72465724
138Abnormality of secondary sexual hair (HP:0009888)1.72408712
139Abnormality of the axillary hair (HP:0100134)1.72408712
140Heterochromia iridis (HP:0001100)1.72248388
141Amyloidosis (HP:0011034)1.72198912
142Type II lissencephaly (HP:0007260)1.72058301
143Bundle branch block (HP:0011710)1.71571096
144Hyperparathyroidism (HP:0000843)1.70081786
145Abnormality of glycolipid metabolism (HP:0010969)1.70042466
146Abnormality of liposaccharide metabolism (HP:0010968)1.70042466
147Abnormality of glycosphingolipid metabolism (HP:0004343)1.70042466
148Neonatal death (HP:0003811)1.69739765
149Multiple lipomas (HP:0001012)1.68368149
150Melanocytic nevus (HP:0000995)1.66393271
151Atrioventricular canal defect (HP:0006695)1.64884862
152Erythema (HP:0010783)1.64392453
153Amyotrophic lateral sclerosis (HP:0007354)1.64254115
154Testicular neoplasm (HP:0010788)1.63294986
155Increased CSF protein (HP:0002922)1.63109859
156Buphthalmos (HP:0000557)1.62125834
157Neoplasm of the thyroid gland (HP:0100031)1.62027989
158Hypercortisolism (HP:0001578)1.60303386
159Vertebral arch anomaly (HP:0008438)1.59896280
160Increased circulating renin level (HP:0000848)1.56764393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.51837682
2NTRK33.38193072
3EPHA43.24213097
4MAP3K92.75492151
5KSR22.63205251
6MARK12.52962800
7MAP2K72.40387338
8STK242.36533142
9MINK12.13355128
10MAP3K42.12146189
11MAP3K122.11470149
12PAK62.07127760
13MAP3K22.05584437
14IRAK22.04652830
15TNIK1.89783685
16TESK11.78890508
17NTRK11.76754212
18MAP3K131.69945204
19CASK1.69841180
20BMPR21.67279900
21PLK21.62503138
22KSR11.62447357
23MAP2K41.58557324
24RIPK11.52798298
25OXSR11.49680204
26TRIM281.47204082
27STK391.45983577
28PAK31.40973262
29INSRR1.40027322
30IRAK11.38371621
31EPHA31.37345522
32ERBB31.33263209
33ARAF1.26821226
34DAPK21.23978540
35MAPK131.23571256
36CDK51.16367774
37CAMK2A1.16263932
38LIMK11.14961013
39FES1.13476484
40BMPR1B1.11877838
41CSNK1G21.10955537
42WNK41.10443352
43RAF11.06379288
44SGK2231.02690851
45SGK4941.02690851
46CAMKK21.00853773
47PNCK1.00784997
48NTRK21.00741502
49FRK1.00478288
50CAMK2B0.99220911
51MAPK70.97266063
52NEK90.96300671
53FGR0.96149737
54TAOK30.95122098
55UHMK10.95065679
56GRK50.94993644
57MAP3K60.94324429
58MAP3K10.94017451
59CDK190.93507305
60FGFR30.92971753
61STK380.92962551
62BCR0.92770435
63DMPK0.92484511
64DYRK1A0.91791553
65PKN10.91017039
66PRKCE0.90404316
67MAPKAPK50.89431150
68SCYL20.88108170
69RET0.86817412
70CAMK2D0.83483548
71MAP3K140.82924769
72SIK20.82215842
73RPS6KB10.81479379
74MOS0.80622526
75GRK70.80130711
76MAPK120.78978393
77BRD40.76842336
78FGFR20.75276651
79MAP4K20.74925658
80MAP2K10.74478179
81CDK60.74312056
82LMTK20.73805818
83CSNK1G30.73658748
84CSNK1A1L0.73185946
85EPHB10.73052936
86PTK2B0.72724861
87PIK3CA0.72086503
88STK30.71398147
89DYRK20.71366538
90PINK10.70861875
91PDGFRA0.70350405
92SGK20.68936140
93MUSK0.68325949
94FER0.68266455
95ERBB40.66167208
96CDK140.65175003
97CAMKK10.63568640
98PRKCG0.62978055
99SGK10.62625230
100CDK11A0.62307290
101MST40.61425494
102MKNK20.61154559
103PHKG10.60746280
104PHKG20.60746280
105CSNK1G10.60390555
106MAPK150.59750504
107CAMK1G0.59640422
108WNK10.59468261
109HIPK20.59295787
110GSK3A0.57996377
111PDPK10.57120064
112TRPM70.55065352
113LATS20.53023775
114TYRO30.50936629
115EPHB20.50713333
116TGFBR10.50068536
117CAMK2G0.49933882
118CDK180.49760244
119MAP3K30.48946938
120PRKCZ0.48878324
121JAK10.48773565
122PRKD30.48740100
123PRPF4B0.48439441
124DYRK1B0.48354610
125FYN0.47630431
126MAPK100.46399787
127CDK150.46024358
128YES10.46004315
129DAPK10.45965919
130TAOK10.45731719
131TGFBR20.45550164
132PRKCQ0.44942272
133SIK30.44732994
134SGK30.44223413
135ROCK20.43517782
136MARK20.41757467
137ABL10.41683060
138PTK20.41468084
139RPS6KA40.40786536
140PTK60.39127892

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.67009639
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26687330
3GABAergic synapse_Homo sapiens_hsa047272.22775595
4Synaptic vesicle cycle_Homo sapiens_hsa047212.21801022
5Long-term potentiation_Homo sapiens_hsa047202.09872576
6Glutamatergic synapse_Homo sapiens_hsa047242.09314794
7Circadian entrainment_Homo sapiens_hsa047131.96624649
8Morphine addiction_Homo sapiens_hsa050321.96616249
9Serotonergic synapse_Homo sapiens_hsa047261.87749548
10Amphetamine addiction_Homo sapiens_hsa050311.84518437
11Dopaminergic synapse_Homo sapiens_hsa047281.83343038
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81640435
13Long-term depression_Homo sapiens_hsa047301.73459428
14Renin secretion_Homo sapiens_hsa049241.71982373
15Olfactory transduction_Homo sapiens_hsa047401.70359655
16Salivary secretion_Homo sapiens_hsa049701.58200629
17Cholinergic synapse_Homo sapiens_hsa047251.56808280
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53119880
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53109752
20Collecting duct acid secretion_Homo sapiens_hsa049661.50887303
21Cocaine addiction_Homo sapiens_hsa050301.48753530
22Insulin secretion_Homo sapiens_hsa049111.48152190
23Taste transduction_Homo sapiens_hsa047421.44372422
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38293184
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34319304
26GnRH signaling pathway_Homo sapiens_hsa049121.33824676
27Gastric acid secretion_Homo sapiens_hsa049711.33225531
28Oxytocin signaling pathway_Homo sapiens_hsa049211.25279196
29Vibrio cholerae infection_Homo sapiens_hsa051101.24194803
30Histidine metabolism_Homo sapiens_hsa003401.24092999
31Axon guidance_Homo sapiens_hsa043601.18646060
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11607422
33cAMP signaling pathway_Homo sapiens_hsa040241.07522018
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07212637
35Calcium signaling pathway_Homo sapiens_hsa040201.06293355
36Gap junction_Homo sapiens_hsa045401.03834544
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03637482
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02721835
39Endometrial cancer_Homo sapiens_hsa052131.01306309
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99688152
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99660723
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97193537
43Caffeine metabolism_Homo sapiens_hsa002320.97043652
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96308027
45Prolactin signaling pathway_Homo sapiens_hsa049170.95033117
46Butanoate metabolism_Homo sapiens_hsa006500.94148797
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92059161
48Estrogen signaling pathway_Homo sapiens_hsa049150.90463717
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.89662915
50Ovarian steroidogenesis_Homo sapiens_hsa049130.87984552
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87805421
52Steroid biosynthesis_Homo sapiens_hsa001000.86918906
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84534447
54Inositol phosphate metabolism_Homo sapiens_hsa005620.84001500
55Bile secretion_Homo sapiens_hsa049760.83530036
56Type II diabetes mellitus_Homo sapiens_hsa049300.82377066
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.82216223
58Glioma_Homo sapiens_hsa052140.80732573
59Insulin signaling pathway_Homo sapiens_hsa049100.80500417
60ErbB signaling pathway_Homo sapiens_hsa040120.80271954
61Melanogenesis_Homo sapiens_hsa049160.79961762
62Pancreatic secretion_Homo sapiens_hsa049720.77142092
63Nitrogen metabolism_Homo sapiens_hsa009100.76906965
64PPAR signaling pathway_Homo sapiens_hsa033200.75875767
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74222895
66Choline metabolism in cancer_Homo sapiens_hsa052310.74023125
67Renal cell carcinoma_Homo sapiens_hsa052110.73959350
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72843818
69* AMPK signaling pathway_Homo sapiens_hsa041520.72766765
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72639834
71Dorso-ventral axis formation_Homo sapiens_hsa043200.71101922
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.71075050
73Alzheimers disease_Homo sapiens_hsa050100.68860965
74Prion diseases_Homo sapiens_hsa050200.68848716
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68133919
76Thyroid hormone synthesis_Homo sapiens_hsa049180.68132971
77mTOR signaling pathway_Homo sapiens_hsa041500.67462321
78VEGF signaling pathway_Homo sapiens_hsa043700.67424674
79Sulfur metabolism_Homo sapiens_hsa009200.67320905
80Lysosome_Homo sapiens_hsa041420.67207205
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66938222
82Ras signaling pathway_Homo sapiens_hsa040140.66627574
83Mineral absorption_Homo sapiens_hsa049780.66506205
84Hepatitis C_Homo sapiens_hsa051600.65965823
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65872900
86Rheumatoid arthritis_Homo sapiens_hsa053230.65849116
87Ether lipid metabolism_Homo sapiens_hsa005650.64254791
88Phagosome_Homo sapiens_hsa041450.64251337
89Amoebiasis_Homo sapiens_hsa051460.62772784
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57888000
91Sphingolipid metabolism_Homo sapiens_hsa006000.57867258
92Complement and coagulation cascades_Homo sapiens_hsa046100.57502566
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57354255
94Phenylalanine metabolism_Homo sapiens_hsa003600.57135430
95beta-Alanine metabolism_Homo sapiens_hsa004100.56055959
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.55864461
97MAPK signaling pathway_Homo sapiens_hsa040100.55569155
98Endocytosis_Homo sapiens_hsa041440.54596549
99African trypanosomiasis_Homo sapiens_hsa051430.53915985
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53826342
101Chronic myeloid leukemia_Homo sapiens_hsa052200.52797109
102Platelet activation_Homo sapiens_hsa046110.52027487
103Regulation of autophagy_Homo sapiens_hsa041400.51774196
104Phototransduction_Homo sapiens_hsa047440.51547198
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50537362
106Chemokine signaling pathway_Homo sapiens_hsa040620.50268342
107Thyroid cancer_Homo sapiens_hsa052160.50231089
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49949082
109Cardiac muscle contraction_Homo sapiens_hsa042600.49714024
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49706227
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.49518212
112Salmonella infection_Homo sapiens_hsa051320.49167313
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49021934
114Shigellosis_Homo sapiens_hsa051310.48683101
115Oxidative phosphorylation_Homo sapiens_hsa001900.47970514
116Focal adhesion_Homo sapiens_hsa045100.46465817
117Glucagon signaling pathway_Homo sapiens_hsa049220.46434747
118Arginine biosynthesis_Homo sapiens_hsa002200.46222211
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.45714678
120Type I diabetes mellitus_Homo sapiens_hsa049400.45666216
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45604215
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45262882
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.44610307
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44398608
125Rap1 signaling pathway_Homo sapiens_hsa040150.43521841
126Dilated cardiomyopathy_Homo sapiens_hsa054140.42151327
127Oocyte meiosis_Homo sapiens_hsa041140.39201656
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38993440
129Tuberculosis_Homo sapiens_hsa051520.38695852
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38028067
131Circadian rhythm_Homo sapiens_hsa047100.37813402
132Fatty acid elongation_Homo sapiens_hsa000620.37611737
133Pancreatic cancer_Homo sapiens_hsa052120.37105699
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36791938

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