

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.28120789 |
| 2 | synaptic vesicle maturation (GO:0016188) | 6.19595436 |
| 3 | locomotory exploration behavior (GO:0035641) | 5.83791777 |
| 4 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.62713532 |
| 5 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.47734831 |
| 6 | synaptic vesicle exocytosis (GO:0016079) | 5.42403352 |
| 7 | glutamate secretion (GO:0014047) | 5.36205335 |
| 8 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.35747345 |
| 9 | vocalization behavior (GO:0071625) | 5.35113606 |
| 10 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.12755245 |
| 11 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.09820483 |
| 12 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.82701497 |
| 13 | protein localization to synapse (GO:0035418) | 4.56397282 |
| 14 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.54336091 |
| 15 | neuronal action potential propagation (GO:0019227) | 4.51854053 |
| 16 | regulation of synaptic vesicle transport (GO:1902803) | 4.51636171 |
| 17 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.51027073 |
| 18 | regulation of synapse structural plasticity (GO:0051823) | 4.50036156 |
| 19 | neurotransmitter secretion (GO:0007269) | 4.46115548 |
| 20 | exploration behavior (GO:0035640) | 4.41191714 |
| 21 | layer formation in cerebral cortex (GO:0021819) | 4.40575612 |
| 22 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.35128755 |
| 23 | dendritic spine morphogenesis (GO:0060997) | 4.13375446 |
| 24 | proline transport (GO:0015824) | 4.12820441 |
| 25 | synaptic transmission, glutamatergic (GO:0035249) | 4.02078617 |
| 26 | cerebellar granule cell differentiation (GO:0021707) | 4.01198526 |
| 27 | cellular potassium ion homeostasis (GO:0030007) | 3.90622862 |
| 28 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.89342438 |
| 29 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.87235835 |
| 30 | neuron cell-cell adhesion (GO:0007158) | 3.85999039 |
| 31 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.84515586 |
| 32 | neuron-neuron synaptic transmission (GO:0007270) | 3.83821099 |
| 33 | long-term memory (GO:0007616) | 3.83108761 |
| 34 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.79912259 |
| 35 | glutamate receptor signaling pathway (GO:0007215) | 3.78351953 |
| 36 | negative regulation of microtubule polymerization (GO:0031115) | 3.75077964 |
| 37 | neuromuscular process controlling balance (GO:0050885) | 3.74381916 |
| 38 | sodium ion export (GO:0071436) | 3.71090861 |
| 39 | positive regulation of membrane potential (GO:0045838) | 3.70568428 |
| 40 | activation of protein kinase A activity (GO:0034199) | 3.68963031 |
| 41 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.65981368 |
| 42 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.65391609 |
| 43 | regulation of synaptic plasticity (GO:0048167) | 3.63114329 |
| 44 | regulation of postsynaptic membrane potential (GO:0060078) | 3.59616840 |
| 45 | gamma-aminobutyric acid transport (GO:0015812) | 3.55851589 |
| 46 | neurotransmitter transport (GO:0006836) | 3.53844103 |
| 47 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.51161813 |
| 48 | prepulse inhibition (GO:0060134) | 3.49455853 |
| 49 | positive regulation of neurotransmitter transport (GO:0051590) | 3.47138261 |
| 50 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.44442821 |
| 51 | regulation of neurotransmitter secretion (GO:0046928) | 3.44263517 |
| 52 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.43816688 |
| 53 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.43159572 |
| 54 | positive regulation of synapse maturation (GO:0090129) | 3.41220717 |
| 55 | auditory behavior (GO:0031223) | 3.40711127 |
| 56 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.39817561 |
| 57 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.38957307 |
| 58 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.38382182 |
| 59 | long-term synaptic potentiation (GO:0060291) | 3.33779326 |
| 60 | regulation of neurotransmitter levels (GO:0001505) | 3.31978593 |
| 61 | response to auditory stimulus (GO:0010996) | 3.31461181 |
| 62 | transmission of nerve impulse (GO:0019226) | 3.28005802 |
| 63 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.26378027 |
| 64 | synaptic vesicle endocytosis (GO:0048488) | 3.23471016 |
| 65 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.23125921 |
| 66 | regulation of neurotransmitter transport (GO:0051588) | 3.21652806 |
| 67 | vesicle transport along microtubule (GO:0047496) | 3.20778393 |
| 68 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.20757908 |
| 69 | regulation of vesicle fusion (GO:0031338) | 3.20372063 |
| 70 | postsynaptic membrane organization (GO:0001941) | 3.20070310 |
| 71 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.19780430 |
| 72 | dendritic spine organization (GO:0097061) | 3.19361631 |
| 73 | neuron recognition (GO:0008038) | 3.17563689 |
| 74 | glycine transport (GO:0015816) | 3.16424637 |
| 75 | neuronal ion channel clustering (GO:0045161) | 3.14885304 |
| 76 | membrane hyperpolarization (GO:0060081) | 3.14319738 |
| 77 | membrane depolarization during action potential (GO:0086010) | 3.13212671 |
| 78 | membrane depolarization (GO:0051899) | 3.12173696 |
| 79 | cell communication involved in cardiac conduction (GO:0086065) | 3.12172382 |
| 80 | neuromuscular process controlling posture (GO:0050884) | 3.10760799 |
| 81 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.10677920 |
| 82 | cell communication by electrical coupling (GO:0010644) | 3.08019845 |
| 83 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.05636392 |
| 84 | amino acid import (GO:0043090) | 3.04269691 |
| 85 | potassium ion homeostasis (GO:0055075) | 3.03874373 |
| 86 | regulation of dendritic spine development (GO:0060998) | 3.03683918 |
| 87 | mating behavior (GO:0007617) | 3.03624702 |
| 88 | establishment of mitochondrion localization (GO:0051654) | 3.02561953 |
| 89 | dendrite morphogenesis (GO:0048813) | 3.01641236 |
| 90 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.00901014 |
| 91 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.00388780 |
| 92 | positive regulation of synaptic transmission (GO:0050806) | 2.99812017 |
| 93 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.99529734 |
| 94 | neuromuscular process (GO:0050905) | 2.99492112 |
| 95 | regulation of ARF protein signal transduction (GO:0032012) | 2.99175219 |
| 96 | innervation (GO:0060384) | 2.98432239 |
| 97 | response to histamine (GO:0034776) | 2.97933372 |
| 98 | axonal fasciculation (GO:0007413) | 2.96691979 |
| 99 | behavioral fear response (GO:0001662) | 2.95048555 |
| 100 | behavioral defense response (GO:0002209) | 2.95048555 |
| 101 | learning (GO:0007612) | 2.94938326 |
| 102 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.94820855 |
| 103 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.94590313 |
| 104 | mitochondrion transport along microtubule (GO:0047497) | 2.94590313 |
| 105 | regulation of synaptic transmission (GO:0050804) | 2.93952177 |
| 106 | neurofilament cytoskeleton organization (GO:0060052) | 2.93586424 |
| 107 | behavioral response to cocaine (GO:0048148) | 2.92575275 |
| 108 | regulation of synapse maturation (GO:0090128) | 2.91704378 |
| 109 | dopamine receptor signaling pathway (GO:0007212) | 2.90181820 |
| 110 | synaptic transmission (GO:0007268) | 2.89801813 |
| 111 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.89685152 |
| 112 | cell migration in hindbrain (GO:0021535) | 2.89004296 |
| 113 | social behavior (GO:0035176) | 2.85638786 |
| 114 | intraspecies interaction between organisms (GO:0051703) | 2.85638786 |
| 115 | synapse assembly (GO:0007416) | 2.85106494 |
| 116 | positive regulation of dendritic spine development (GO:0060999) | 2.85034591 |
| 117 | L-amino acid import (GO:0043092) | 2.83596017 |
| 118 | cochlea development (GO:0090102) | 2.81747305 |
| 119 | apical protein localization (GO:0045176) | 2.77869317 |
| 120 | presynaptic membrane organization (GO:0097090) | 2.76452503 |
| 121 | cerebellar Purkinje cell layer development (GO:0021680) | 2.74856623 |
| 122 | chemosensory behavior (GO:0007635) | 2.71732494 |
| 123 | response to parathyroid hormone (GO:0071107) | 2.68668425 |
| 124 | cell-cell junction maintenance (GO:0045217) | 2.67563734 |
| 125 | cell differentiation in hindbrain (GO:0021533) | 2.65309987 |
| 126 | central nervous system myelination (GO:0022010) | 2.61604785 |
| 127 | axon ensheathment in central nervous system (GO:0032291) | 2.61604785 |
| 128 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.56315759 |
| 129 | receptor recycling (GO:0001881) | 2.45312970 |
| 130 | cellular sodium ion homeostasis (GO:0006883) | 2.43796496 |
| 131 | cerebellum development (GO:0021549) | 2.43725164 |
| 132 | axon extension (GO:0048675) | 2.43186822 |
| 133 | regulation of heart rate by cardiac conduction (GO:0086091) | 2.42415740 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.38483466 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.51614970 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.13321881 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.10122497 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.99800830 |
| 6 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.90202410 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.80594614 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.80594614 |
| 9 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.79876573 |
| 10 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.73592020 |
| 11 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.64283366 |
| 12 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.61701792 |
| 13 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.61686555 |
| 14 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.57849660 |
| 15 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.57796291 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.49822487 |
| 17 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.44691757 |
| 18 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.39849923 |
| 19 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.28742526 |
| 20 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.26413875 |
| 21 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.22919626 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.22167118 |
| 23 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.20698928 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.20192014 |
| 25 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.16932685 |
| 26 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.14702973 |
| 27 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.00468832 |
| 28 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.92853358 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.90288259 |
| 30 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.86818543 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.84427461 |
| 32 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.78058783 |
| 33 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.67727300 |
| 34 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.60933885 |
| 35 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.54884256 |
| 36 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.50523875 |
| 37 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.44922465 |
| 38 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.42512885 |
| 39 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.41564390 |
| 40 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.40247787 |
| 41 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.39855408 |
| 42 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.39422790 |
| 43 | KDM2B_26808549_Chip-Seq_K562_Human | 1.38960369 |
| 44 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.37416074 |
| 45 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.35341995 |
| 46 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.35056669 |
| 47 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.34984006 |
| 48 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.34655976 |
| 49 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.34481087 |
| 50 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.33859302 |
| 51 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.32814263 |
| 52 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.32065935 |
| 53 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.32036967 |
| 54 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.30851555 |
| 55 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.30388594 |
| 56 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.29902862 |
| 57 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.29425968 |
| 58 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.28038022 |
| 59 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.27842477 |
| 60 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.26092199 |
| 61 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.24971679 |
| 62 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.24901640 |
| 63 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.24791462 |
| 64 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.24358064 |
| 65 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.23326754 |
| 66 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.21450016 |
| 67 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.20947680 |
| 68 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.20079551 |
| 69 | AR_19668381_ChIP-Seq_PC3_Human | 1.19997846 |
| 70 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.18057114 |
| 71 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.18021497 |
| 72 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.17776934 |
| 73 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.16345653 |
| 74 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.16251744 |
| 75 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.16237305 |
| 76 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.14869090 |
| 77 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 1.12996110 |
| 78 | AR_25329375_ChIP-Seq_VCAP_Human | 1.12986519 |
| 79 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.12685065 |
| 80 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.12258735 |
| 81 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.09504541 |
| 82 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.09292523 |
| 83 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.09063406 |
| 84 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.08654696 |
| 85 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.08088127 |
| 86 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.08026768 |
| 87 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.07391472 |
| 88 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.06631779 |
| 89 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.05840917 |
| 90 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.05618068 |
| 91 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.04457797 |
| 92 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.03812860 |
| 93 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.03443590 |
| 94 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.03206209 |
| 95 | STAT3_23295773_ChIP-Seq_U87_Human | 1.02541368 |
| 96 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.02313226 |
| 97 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.01825744 |
| 98 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.00311885 |
| 99 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.00290203 |
| 100 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.99954466 |
| 101 | P300_19829295_ChIP-Seq_ESCs_Human | 0.99357134 |
| 102 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.99202666 |
| 103 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.99136974 |
| 104 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.99088585 |
| 105 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.98797473 |
| 106 | P68_20966046_ChIP-Seq_HELA_Human | 0.98147298 |
| 107 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.97637503 |
| 108 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.97137099 |
| 109 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.96346738 |
| 110 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.94877411 |
| 111 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.94523584 |
| 112 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.94423760 |
| 113 | KAP1_27257070_Chip-Seq_ESCs_Mouse | 0.94416406 |
| 114 | RXR_22108803_ChIP-Seq_LS180_Human | 0.94037931 |
| 115 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.93747952 |
| 116 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.93574865 |
| 117 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.93470436 |
| 118 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.93332874 |
| 119 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.92976813 |
| 120 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.91852365 |
| 121 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.90930962 |
| 122 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.90688200 |
| 123 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.90662360 |
| 124 | TCF4_23295773_ChIP-Seq_U87_Human | 0.90602983 |
| 125 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.90508009 |
| 126 | * ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.90446336 |
| 127 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.90386134 |
| 128 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.89995496 |
| 129 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.89219323 |
| 130 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.88167074 |
| 131 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 0.87898161 |
| 132 | TP53_16413492_ChIP-PET_HCT116_Human | 0.87003568 |
| 133 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.86525576 |
| 134 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.86410910 |
| 135 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.85870793 |
| 136 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.85748065 |
| 137 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.85676715 |
| 138 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.85613728 |
| 139 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.85208209 |
| 140 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.83141870 |
| 141 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.83121226 |
| 142 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.83031976 |
| 143 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.82903137 |
| 144 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.82828334 |
| 145 | TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 0.82807606 |
| 146 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.82532168 |
| 147 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.81541984 |
| 148 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81429857 |
| 149 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.81282854 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.95857902 |
| 2 | MP0003880_abnormal_central_pattern | 4.37526065 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.21164248 |
| 4 | MP0004270_analgesia | 3.93077082 |
| 5 | MP0002822_catalepsy | 3.85113716 |
| 6 | MP0003123_paternal_imprinting | 3.71668897 |
| 7 | MP0009745_abnormal_behavioral_response | 3.40425523 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.37810094 |
| 9 | MP0001968_abnormal_touch/_nociception | 3.23568764 |
| 10 | MP0002064_seizures | 3.07794783 |
| 11 | MP0009046_muscle_twitch | 2.88909807 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.77323716 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.73122421 |
| 14 | MP0002272_abnormal_nervous_system | 2.53601928 |
| 15 | MP0005423_abnormal_somatic_nervous | 2.50762357 |
| 16 | MP0002736_abnormal_nociception_after | 2.46017384 |
| 17 | MP0001486_abnormal_startle_reflex | 2.43736221 |
| 18 | MP0002735_abnormal_chemical_nociception | 2.33341024 |
| 19 | MP0001501_abnormal_sleep_pattern | 2.29476181 |
| 20 | MP0004858_abnormal_nervous_system | 2.24115672 |
| 21 | MP0002733_abnormal_thermal_nociception | 2.17541767 |
| 22 | MP0009780_abnormal_chondrocyte_physiolo | 2.15078342 |
| 23 | MP0001970_abnormal_pain_threshold | 2.07364048 |
| 24 | MP0002909_abnormal_adrenal_gland | 2.02902230 |
| 25 | MP0001440_abnormal_grooming_behavior | 2.02681676 |
| 26 | MP0003329_amyloid_beta_deposits | 1.92093365 |
| 27 | MP0010234_abnormal_vibrissa_follicle | 1.90983503 |
| 28 | MP0008569_lethality_at_weaning | 1.88684783 |
| 29 | MP0003890_abnormal_embryonic-extraembry | 1.86939214 |
| 30 | MP0004811_abnormal_neuron_physiology | 1.84400774 |
| 31 | MP0002067_abnormal_sensory_capabilities | 1.80406981 |
| 32 | MP0002184_abnormal_innervation | 1.74211449 |
| 33 | MP0003879_abnormal_hair_cell | 1.71592630 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.70154844 |
| 35 | MP0004924_abnormal_behavior | 1.66560684 |
| 36 | MP0005386_behavior/neurological_phenoty | 1.66560684 |
| 37 | MP0000778_abnormal_nervous_system | 1.60438704 |
| 38 | MP0003121_genomic_imprinting | 1.58867925 |
| 39 | MP0000955_abnormal_spinal_cord | 1.51885502 |
| 40 | MP0004885_abnormal_endolymph | 1.49314361 |
| 41 | MP0000566_synostosis | 1.44902195 |
| 42 | MP0005646_abnormal_pituitary_gland | 1.43226917 |
| 43 | MP0008877_abnormal_DNA_methylation | 1.40233940 |
| 44 | MP0006276_abnormal_autonomic_nervous | 1.37972933 |
| 45 | MP0003633_abnormal_nervous_system | 1.35611167 |
| 46 | MP0002066_abnormal_motor_capabilities/c | 1.35144521 |
| 47 | MP0002882_abnormal_neuron_morphology | 1.34779590 |
| 48 | MP0009672_abnormal_birth_weight | 1.32099301 |
| 49 | MP0000462_abnormal_digestive_system | 1.28330669 |
| 50 | MP0001984_abnormal_olfaction | 1.25535811 |
| 51 | MP0001348_abnormal_lacrimal_gland | 1.20053416 |
| 52 | MP0003787_abnormal_imprinting | 1.19239570 |
| 53 | MP0002089_abnormal_postnatal_growth/wei | 1.17821089 |
| 54 | MP0001529_abnormal_vocalization | 1.16734523 |
| 55 | MP0000537_abnormal_urethra_morphology | 1.16669563 |
| 56 | MP0008872_abnormal_physiological_respon | 1.16575899 |
| 57 | MP0003119_abnormal_digestive_system | 1.15037949 |
| 58 | MP0003631_nervous_system_phenotype | 1.13430926 |
| 59 | MP0004133_heterotaxia | 1.12218935 |
| 60 | MP0003075_altered_response_to | 1.09971497 |
| 61 | MP0001346_abnormal_lacrimal_gland | 1.08391142 |
| 62 | MP0001905_abnormal_dopamine_level | 1.08340774 |
| 63 | MP0001502_abnormal_circadian_rhythm | 1.07326417 |
| 64 | MP0005645_abnormal_hypothalamus_physiol | 1.03520059 |
| 65 | MP0002152_abnormal_brain_morphology | 1.03474501 |
| 66 | MP0001177_atelectasis | 1.02212286 |
| 67 | MP0010386_abnormal_urinary_bladder | 0.99669108 |
| 68 | MP0008961_abnormal_basal_metabolism | 0.99063541 |
| 69 | MP0000751_myopathy | 0.98379246 |
| 70 | MP0008874_decreased_physiological_sensi | 0.96810209 |
| 71 | MP0003283_abnormal_digestive_organ | 0.94755253 |
| 72 | MP0000569_abnormal_digit_pigmentation | 0.94098180 |
| 73 | MP0003122_maternal_imprinting | 0.93802678 |
| 74 | MP0002069_abnormal_eating/drinking_beha | 0.91479166 |
| 75 | MP0003705_abnormal_hypodermis_morpholog | 0.86601365 |
| 76 | MP0003942_abnormal_urinary_system | 0.86597954 |
| 77 | MP0000604_amyloidosis | 0.86026469 |
| 78 | MP0004264_abnormal_extraembryonic_tissu | 0.85436924 |
| 79 | MP0002796_impaired_skin_barrier | 0.85283945 |
| 80 | MP0000678_abnormal_parathyroid_gland | 0.83646768 |
| 81 | MP0000013_abnormal_adipose_tissue | 0.83066330 |
| 82 | MP0002229_neurodegeneration | 0.82887945 |
| 83 | MP0000579_abnormal_nail_morphology | 0.82024950 |
| 84 | MP0003632_abnormal_nervous_system | 0.81257757 |
| 85 | MP0004142_abnormal_muscle_tone | 0.80438778 |
| 86 | MP0001664_abnormal_digestion | 0.79264447 |
| 87 | MP0005499_abnormal_olfactory_system | 0.78978176 |
| 88 | MP0005394_taste/olfaction_phenotype | 0.78978176 |
| 89 | MP0004085_abnormal_heartbeat | 0.77762786 |
| 90 | MP0005167_abnormal_blood-brain_barrier | 0.77540461 |
| 91 | MP0005623_abnormal_meninges_morphology | 0.77005872 |
| 92 | MP0004145_abnormal_muscle_electrophysio | 0.76714059 |
| 93 | MP0005535_abnormal_body_temperature | 0.75327569 |
| 94 | MP0002254_reproductive_system_inflammat | 0.73760834 |
| 95 | MP0003634_abnormal_glial_cell | 0.73041720 |
| 96 | MP0001188_hyperpigmentation | 0.72254173 |
| 97 | MP0002081_perinatal_lethality | 0.71797118 |
| 98 | MP0003690_abnormal_glial_cell | 0.70950476 |
| 99 | MP0002090_abnormal_vision | 0.70174766 |
| 100 | MP0009379_abnormal_foot_pigmentation | 0.69774164 |
| 101 | MP0004742_abnormal_vestibular_system | 0.68572203 |
| 102 | MP0001963_abnormal_hearing_physiology | 0.67653348 |
| 103 | MP0003938_abnormal_ear_development | 0.67388505 |
| 104 | MP0001485_abnormal_pinna_reflex | 0.66532326 |
| 105 | MP0000920_abnormal_myelination | 0.65924387 |
| 106 | MP0001849_ear_inflammation | 0.64152245 |
| 107 | MP0003941_abnormal_skin_development | 0.63465335 |
| 108 | MP0001299_abnormal_eye_distance/ | 0.63050646 |
| 109 | MP0002752_abnormal_somatic_nervous | 0.61170019 |
| 110 | MP0000631_abnormal_neuroendocrine_gland | 0.60900938 |
| 111 | MP0002249_abnormal_larynx_morphology | 0.60860595 |
| 112 | MP0005187_abnormal_penis_morphology | 0.60529320 |
| 113 | MP0004484_altered_response_of | 0.60321823 |
| 114 | MP0010770_preweaning_lethality | 0.60147525 |
| 115 | MP0002082_postnatal_lethality | 0.60147525 |
| 116 | MP0004185_abnormal_adipocyte_glucose | 0.59987143 |
| 117 | MP0001943_abnormal_respiration | 0.59079159 |
| 118 | MP0000534_abnormal_ureter_morphology | 0.58670808 |
| 119 | MP0004043_abnormal_pH_regulation | 0.54931556 |
| 120 | MP0005166_decreased_susceptibility_to | 0.54628128 |
| 121 | MP0003183_abnormal_peptide_metabolism | 0.54534744 |
| 122 | MP0005551_abnormal_eye_electrophysiolog | 0.52263800 |
| 123 | MP0004233_abnormal_muscle_weight | 0.52064560 |
| 124 | MP0003861_abnormal_nervous_system | 0.51384884 |
| 125 | MP0003137_abnormal_impulse_conducting | 0.51036303 |
| 126 | MP0010769_abnormal_survival | 0.49788451 |
| 127 | MP0005409_darkened_coat_color | 0.48262290 |
| 128 | MP0004130_abnormal_muscle_cell | 0.48066104 |
| 129 | MP0003956_abnormal_body_size | 0.47561245 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 7.77605966 |
| 2 | Focal motor seizures (HP:0011153) | 7.21717935 |
| 3 | Focal seizures (HP:0007359) | 5.64768869 |
| 4 | Visual hallucinations (HP:0002367) | 5.19234101 |
| 5 | Action tremor (HP:0002345) | 4.33980119 |
| 6 | Atonic seizures (HP:0010819) | 4.28769967 |
| 7 | Epileptic encephalopathy (HP:0200134) | 4.27132913 |
| 8 | Febrile seizures (HP:0002373) | 3.98243495 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 3.95250039 |
| 10 | Absence seizures (HP:0002121) | 3.87107776 |
| 11 | Ankle clonus (HP:0011448) | 3.81490022 |
| 12 | Generalized tonic-clonic seizures (HP:0002069) | 3.63069792 |
| 13 | Supranuclear gaze palsy (HP:0000605) | 3.54551793 |
| 14 | Dialeptic seizures (HP:0011146) | 3.48612759 |
| 15 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.43916077 |
| 16 | Hepatoblastoma (HP:0002884) | 3.43106552 |
| 17 | Poor eye contact (HP:0000817) | 3.41086443 |
| 18 | Depression (HP:0000716) | 3.25102769 |
| 19 | Broad-based gait (HP:0002136) | 3.24080532 |
| 20 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.17925722 |
| 21 | Abnormal pancreas size (HP:0012094) | 3.17317219 |
| 22 | Gaze-evoked nystagmus (HP:0000640) | 3.15717314 |
| 23 | Papilledema (HP:0001085) | 3.13393332 |
| 24 | Impaired social interactions (HP:0000735) | 3.11343094 |
| 25 | Abnormal social behavior (HP:0012433) | 3.11343094 |
| 26 | Anxiety (HP:0000739) | 3.00317927 |
| 27 | Dysdiadochokinesis (HP:0002075) | 2.99070008 |
| 28 | Urinary urgency (HP:0000012) | 2.96868951 |
| 29 | Annular pancreas (HP:0001734) | 2.93881907 |
| 30 | Torticollis (HP:0000473) | 2.93339726 |
| 31 | Dysmetria (HP:0001310) | 2.92793670 |
| 32 | Akinesia (HP:0002304) | 2.91987259 |
| 33 | Abnormality of the lower motor neuron (HP:0002366) | 2.91673911 |
| 34 | Amblyopia (HP:0000646) | 2.91151462 |
| 35 | Postural instability (HP:0002172) | 2.86458649 |
| 36 | Truncal ataxia (HP:0002078) | 2.84948043 |
| 37 | Mutism (HP:0002300) | 2.82071889 |
| 38 | Ventricular fibrillation (HP:0001663) | 2.73935829 |
| 39 | Insidious onset (HP:0003587) | 2.73439614 |
| 40 | Termporal pattern (HP:0011008) | 2.73439614 |
| 41 | Abnormal eating behavior (HP:0100738) | 2.72426914 |
| 42 | Scanning speech (HP:0002168) | 2.66747689 |
| 43 | Focal dystonia (HP:0004373) | 2.65785496 |
| 44 | Impaired smooth pursuit (HP:0007772) | 2.61131356 |
| 45 | Stereotypic behavior (HP:0000733) | 2.58870340 |
| 46 | Genetic anticipation (HP:0003743) | 2.54371407 |
| 47 | Cerebral inclusion bodies (HP:0100314) | 2.51936085 |
| 48 | Spastic gait (HP:0002064) | 2.51059728 |
| 49 | Intention tremor (HP:0002080) | 2.50047770 |
| 50 | Resting tremor (HP:0002322) | 2.48491063 |
| 51 | Hyperacusis (HP:0010780) | 2.48201803 |
| 52 | Dysmetric saccades (HP:0000641) | 2.47500997 |
| 53 | Megalencephaly (HP:0001355) | 2.44060023 |
| 54 | Craniofacial dystonia (HP:0012179) | 2.42119521 |
| 55 | Hemiplegia (HP:0002301) | 2.40261233 |
| 56 | Neurofibrillary tangles (HP:0002185) | 2.37477346 |
| 57 | Bradykinesia (HP:0002067) | 2.35490490 |
| 58 | Pointed chin (HP:0000307) | 2.35209391 |
| 59 | Hyperventilation (HP:0002883) | 2.31950761 |
| 60 | Ankyloglossia (HP:0010296) | 2.27552350 |
| 61 | Impaired vibratory sensation (HP:0002495) | 2.26945481 |
| 62 | Drooling (HP:0002307) | 2.24648700 |
| 63 | Excessive salivation (HP:0003781) | 2.24648700 |
| 64 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.23800590 |
| 65 | Hyperphosphatemia (HP:0002905) | 2.23429198 |
| 66 | Overriding aorta (HP:0002623) | 2.21212401 |
| 67 | Hemiparesis (HP:0001269) | 2.20967055 |
| 68 | Lower limb muscle weakness (HP:0007340) | 2.18487406 |
| 69 | Turricephaly (HP:0000262) | 2.16843171 |
| 70 | Bundle branch block (HP:0011710) | 2.16323044 |
| 71 | Status epilepticus (HP:0002133) | 2.15112926 |
| 72 | Progressive inability to walk (HP:0002505) | 2.14060097 |
| 73 | Insomnia (HP:0100785) | 2.13669027 |
| 74 | Limb dystonia (HP:0002451) | 2.13548367 |
| 75 | Cerebral hypomyelination (HP:0006808) | 2.12676542 |
| 76 | Abnormality of the corticospinal tract (HP:0002492) | 2.11567772 |
| 77 | Abnormality of binocular vision (HP:0011514) | 2.08178004 |
| 78 | Diplopia (HP:0000651) | 2.08178004 |
| 79 | Upper limb amyotrophy (HP:0009129) | 2.07718134 |
| 80 | Distal upper limb amyotrophy (HP:0007149) | 2.07718134 |
| 81 | Pheochromocytoma (HP:0002666) | 2.07368187 |
| 82 | Hand muscle atrophy (HP:0009130) | 2.06417412 |
| 83 | Fetal akinesia sequence (HP:0001989) | 2.04019256 |
| 84 | Sleep apnea (HP:0010535) | 2.03666142 |
| 85 | Obstructive sleep apnea (HP:0002870) | 2.03286489 |
| 86 | Hypercalciuria (HP:0002150) | 2.03182078 |
| 87 | Epileptiform EEG discharges (HP:0011182) | 2.00693487 |
| 88 | Tetraplegia (HP:0002445) | 1.99310556 |
| 89 | Clonus (HP:0002169) | 1.98749790 |
| 90 | Poor suck (HP:0002033) | 1.97963172 |
| 91 | Incomplete penetrance (HP:0003829) | 1.97790949 |
| 92 | Lower limb asymmetry (HP:0100559) | 1.95830019 |
| 93 | Germ cell neoplasia (HP:0100728) | 1.94046429 |
| 94 | EEG with generalized epileptiform discharges (HP:0011198) | 1.93911493 |
| 95 | Abnormality of the labia minora (HP:0012880) | 1.93512986 |
| 96 | Rapidly progressive (HP:0003678) | 1.92532883 |
| 97 | Lower limb amyotrophy (HP:0007210) | 1.91587065 |
| 98 | Gait ataxia (HP:0002066) | 1.89671955 |
| 99 | Spastic tetraparesis (HP:0001285) | 1.88326811 |
| 100 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.88297382 |
| 101 | Aplasia of the phalanges of the hand (HP:0009802) | 1.88297382 |
| 102 | Aplasia involving bones of the extremities (HP:0009825) | 1.88297382 |
| 103 | Enlarged penis (HP:0000040) | 1.87629993 |
| 104 | Neuronal loss in central nervous system (HP:0002529) | 1.87437554 |
| 105 | Abnormality of the aortic arch (HP:0012303) | 1.86886132 |
| 106 | Agitation (HP:0000713) | 1.86426929 |
| 107 | Hypsarrhythmia (HP:0002521) | 1.85821174 |
| 108 | Hypoventilation (HP:0002791) | 1.84584705 |
| 109 | Abnormality of magnesium homeostasis (HP:0004921) | 1.82445285 |
| 110 | Elfin facies (HP:0004428) | 1.79177169 |
| 111 | Rigidity (HP:0002063) | 1.79100217 |
| 112 | Postural tremor (HP:0002174) | 1.79011607 |
| 113 | Absent speech (HP:0001344) | 1.77864750 |
| 114 | Bronchomalacia (HP:0002780) | 1.76874786 |
| 115 | Abnormal EKG (HP:0003115) | 1.76321938 |
| 116 | Generalized hypotonia (HP:0001290) | 1.76103712 |
| 117 | Amyotrophic lateral sclerosis (HP:0007354) | 1.75343412 |
| 118 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.75044965 |
| 119 | Dysphonia (HP:0001618) | 1.74016901 |
| 120 | Apathy (HP:0000741) | 1.73352240 |
| 121 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 1.72489027 |
| 122 | Inability to walk (HP:0002540) | 1.72293674 |
| 123 | Abnormality of saccadic eye movements (HP:0000570) | 1.70588496 |
| 124 | Choanal stenosis (HP:0000452) | 1.70210429 |
| 125 | Neuroendocrine neoplasm (HP:0100634) | 1.69867663 |
| 126 | Generalized myoclonic seizures (HP:0002123) | 1.69852089 |
| 127 | Neoplasm of the adrenal cortex (HP:0100641) | 1.69365620 |
| 128 | Hypercalcemia (HP:0003072) | 1.68370560 |
| 129 | Hyperparathyroidism (HP:0000843) | 1.67461068 |
| 130 | Partial duplication of thumb phalanx (HP:0009944) | 1.67300788 |
| 131 | Shawl scrotum (HP:0000049) | 1.66321720 |
| 132 | Neonatal hypoglycemia (HP:0001998) | 1.66079182 |
| 133 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.65180752 |
| 134 | Osteomalacia (HP:0002749) | 1.64371024 |
| 135 | Anosmia (HP:0000458) | 1.58291698 |
| 136 | Hypercortisolism (HP:0001578) | 1.58047124 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.65444837 |
| 2 | MAP3K9 | 4.35379809 |
| 3 | NTRK3 | 4.12561739 |
| 4 | DAPK2 | 3.27105574 |
| 5 | KSR2 | 2.71498316 |
| 6 | MINK1 | 2.69517167 |
| 7 | MAP3K4 | 2.67002029 |
| 8 | MARK1 | 2.47596114 |
| 9 | PRKD3 | 2.34662710 |
| 10 | PAK6 | 2.21695822 |
| 11 | NTRK1 | 2.16128643 |
| 12 | CAMKK1 | 2.08844628 |
| 13 | MAP2K7 | 1.99333017 |
| 14 | RIPK4 | 1.99070232 |
| 15 | MAP3K2 | 1.86281857 |
| 16 | MAP3K12 | 1.80470447 |
| 17 | SMG1 | 1.78993311 |
| 18 | DAPK1 | 1.78129363 |
| 19 | NTRK2 | 1.74263744 |
| 20 | MAP2K4 | 1.73308825 |
| 21 | KSR1 | 1.66998551 |
| 22 | ARAF | 1.60723524 |
| 23 | CDK5 | 1.54832510 |
| 24 | ICK | 1.52151961 |
| 25 | STK38 | 1.48181918 |
| 26 | GRK5 | 1.41913482 |
| 27 | SIK1 | 1.41868511 |
| 28 | EEF2K | 1.38284508 |
| 29 | CDK19 | 1.32591362 |
| 30 | TYRO3 | 1.32498556 |
| 31 | TAOK1 | 1.28309537 |
| 32 | LMTK2 | 1.27865786 |
| 33 | LATS2 | 1.27419352 |
| 34 | PLK2 | 1.20948075 |
| 35 | MAP3K13 | 1.20213453 |
| 36 | CAMKK2 | 1.13815250 |
| 37 | RET | 1.13538872 |
| 38 | SIK2 | 1.08517095 |
| 39 | BRAF | 1.06494741 |
| 40 | PRKCG | 1.03700770 |
| 41 | TESK1 | 1.00343394 |
| 42 | LIMK1 | 0.98593138 |
| 43 | PNCK | 0.97225026 |
| 44 | UHMK1 | 0.95705422 |
| 45 | PRPF4B | 0.94903930 |
| 46 | MAPK13 | 0.94359582 |
| 47 | FES | 0.93944665 |
| 48 | CAMK1 | 0.93337880 |
| 49 | EPHA2 | 0.92399415 |
| 50 | RAF1 | 0.90551188 |
| 51 | CASK | 0.90525381 |
| 52 | CDK18 | 0.87180193 |
| 53 | CDK15 | 0.86445801 |
| 54 | STK11 | 0.86212179 |
| 55 | PHKG1 | 0.85932425 |
| 56 | PHKG2 | 0.85932425 |
| 57 | CDK14 | 0.84695716 |
| 58 | RIPK1 | 0.83251998 |
| 59 | ALK | 0.83227596 |
| 60 | TNIK | 0.83061994 |
| 61 | WNK4 | 0.82188039 |
| 62 | DYRK2 | 0.81930741 |
| 63 | CAMK2A | 0.81577837 |
| 64 | PTK2 | 0.81180497 |
| 65 | SGK223 | 0.80374375 |
| 66 | SGK494 | 0.80374375 |
| 67 | MUSK | 0.77751368 |
| 68 | FER | 0.77536627 |
| 69 | PRKCH | 0.77047933 |
| 70 | OXSR1 | 0.77043302 |
| 71 | PBK | 0.77035283 |
| 72 | PTK2B | 0.76604506 |
| 73 | FGFR4 | 0.75187508 |
| 74 | CDK11A | 0.74567549 |
| 75 | MAP3K1 | 0.72961560 |
| 76 | PDPK1 | 0.71773731 |
| 77 | PDK1 | 0.70496951 |
| 78 | PAK3 | 0.69999282 |
| 79 | AKT3 | 0.67246954 |
| 80 | PRKG2 | 0.66697279 |
| 81 | CDK12 | 0.66634828 |
| 82 | PINK1 | 0.66605449 |
| 83 | CSNK1E | 0.65806245 |
| 84 | NEK1 | 0.65525027 |
| 85 | CAMK2B | 0.64845598 |
| 86 | MAP2K1 | 0.64732326 |
| 87 | SGK3 | 0.64540348 |
| 88 | SGK1 | 0.62706384 |
| 89 | SGK2 | 0.61050606 |
| 90 | DAPK3 | 0.60175851 |
| 91 | SCYL2 | 0.60166176 |
| 92 | TNK2 | 0.58670990 |
| 93 | MARK2 | 0.57524507 |
| 94 | CSNK1G2 | 0.54697940 |
| 95 | DDR2 | 0.54086941 |
| 96 | MTOR | 0.52459825 |
| 97 | BMX | 0.50407337 |
| 98 | CDC42BPA | 0.49918820 |
| 99 | PRKCZ | 0.49727028 |
| 100 | TAF1 | 0.49149762 |
| 101 | CAMK1G | 0.48234833 |
| 102 | RPS6KB2 | 0.48229312 |
| 103 | BMPR2 | 0.48144042 |
| 104 | FYN | 0.46619325 |
| 105 | PDGFRA | 0.46038140 |
| 106 | MAP3K7 | 0.45863826 |
| 107 | PRKCI | 0.45680536 |
| 108 | RPS6KA3 | 0.44226741 |
| 109 | ROCK2 | 0.44217919 |
| 110 | NME1 | 0.44183151 |
| 111 | RPS6KA2 | 0.44162344 |
| 112 | MAP2K2 | 0.42833113 |
| 113 | STK39 | 0.42572262 |
| 114 | DYRK1A | 0.42285975 |
| 115 | CAMK4 | 0.42258294 |
| 116 | GSK3B | 0.42022093 |
| 117 | DMPK | 0.41879716 |
| 118 | WNK1 | 0.41615086 |
| 119 | PRKCE | 0.41206433 |
| 120 | CAMK2G | 0.40706707 |
| 121 | BRSK1 | 0.39186583 |
| 122 | CAMK2D | 0.38030882 |
| 123 | ERBB2 | 0.37279333 |
| 124 | MAPK10 | 0.36226156 |
| 125 | FGFR2 | 0.35687677 |
| 126 | NEK6 | 0.30291068 |
| 127 | TRIB3 | 0.29956531 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.30595749 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.13981221 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.82923200 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 2.63508779 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.52702494 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.43413253 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.39811774 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.38428607 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.37701649 |
| 10 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.31782330 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 2.27589314 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.20804217 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.13724314 |
| 14 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.99674670 |
| 15 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.92116669 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 1.91856426 |
| 17 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.91684525 |
| 18 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.78737701 |
| 19 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.69813923 |
| 20 | Cocaine addiction_Homo sapiens_hsa05030 | 1.68426116 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.66294061 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.65358219 |
| 23 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.60861492 |
| 24 | Long-term depression_Homo sapiens_hsa04730 | 1.60326948 |
| 25 | Taste transduction_Homo sapiens_hsa04742 | 1.60311565 |
| 26 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.53770053 |
| 27 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.52430731 |
| 28 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.48324636 |
| 29 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.45485242 |
| 30 | Gap junction_Homo sapiens_hsa04540 | 1.39550954 |
| 31 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.37809559 |
| 32 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.34801597 |
| 33 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.32637411 |
| 34 | Glioma_Homo sapiens_hsa05214 | 1.26156724 |
| 35 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.24798831 |
| 36 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.23642577 |
| 37 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.20623406 |
| 38 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.19240152 |
| 39 | Melanogenesis_Homo sapiens_hsa04916 | 1.11536749 |
| 40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.11531721 |
| 41 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.11438231 |
| 42 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.10758167 |
| 43 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.08401197 |
| 44 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.01312799 |
| 45 | Axon guidance_Homo sapiens_hsa04360 | 1.00324231 |
| 46 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.99795716 |
| 47 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.99643959 |
| 48 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.96902442 |
| 49 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.93836832 |
| 50 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.93269641 |
| 51 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.92824167 |
| 52 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.91378632 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.91113177 |
| 54 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.88982180 |
| 55 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.85630826 |
| 56 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.84844036 |
| 57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.82183787 |
| 58 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.80672774 |
| 59 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.76243331 |
| 60 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.76205852 |
| 61 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.75493272 |
| 62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.75354025 |
| 63 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.75046583 |
| 64 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.72217094 |
| 65 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.71757824 |
| 66 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.71075564 |
| 67 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.71020524 |
| 68 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.70341329 |
| 69 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.69436790 |
| 70 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.69425648 |
| 71 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.69329728 |
| 72 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.68289990 |
| 73 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67256453 |
| 74 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.66157536 |
| 75 | Endometrial cancer_Homo sapiens_hsa05213 | 0.65805260 |
| 76 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.62779059 |
| 77 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.61526781 |
| 78 | Endocytosis_Homo sapiens_hsa04144 | 0.60618669 |
| 79 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.59898393 |
| 80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.57267905 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.56877819 |
| 82 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.56155160 |
| 83 | Thyroid cancer_Homo sapiens_hsa05216 | 0.56068452 |
| 84 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.55272073 |
| 85 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.53795034 |
| 86 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.52991365 |
| 87 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.52598012 |
| 88 | Bile secretion_Homo sapiens_hsa04976 | 0.52372592 |
| 89 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.51895004 |
| 90 | Adherens junction_Homo sapiens_hsa04520 | 0.51289500 |
| 91 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.51211283 |
| 92 | Phototransduction_Homo sapiens_hsa04744 | 0.50628816 |
| 93 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.49266604 |
| 94 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.49178382 |
| 95 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.48660823 |
| 96 | Alcoholism_Homo sapiens_hsa05034 | 0.48609071 |
| 97 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.48076921 |
| 98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.45332764 |
| 99 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.45258895 |
| 100 | Tight junction_Homo sapiens_hsa04530 | 0.45218375 |
| 101 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.44615972 |
| 102 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.44155673 |
| 103 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.42744791 |
| 104 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.42425687 |
| 105 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.41934995 |
| 106 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.41199557 |
| 107 | Prion diseases_Homo sapiens_hsa05020 | 0.41153977 |
| 108 | Circadian rhythm_Homo sapiens_hsa04710 | 0.37513582 |
| 109 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.37155644 |
| 110 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.36740551 |
| 111 | Histidine metabolism_Homo sapiens_hsa00340 | 0.36102444 |
| 112 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.33851480 |
| 113 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.33577704 |
| 114 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.32749747 |
| 115 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32533883 |
| 116 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.31996770 |
| 117 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.31825024 |
| 118 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.31059421 |
| 119 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.30817791 |
| 120 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.30488385 |
| 121 | Colorectal cancer_Homo sapiens_hsa05210 | 0.30165303 |

