RAB17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.87859643
2L-phenylalanine catabolic process (GO:0006559)6.87859643
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.86647219
4L-phenylalanine metabolic process (GO:0006558)6.86647219
5aromatic amino acid family catabolic process (GO:0009074)6.29133074
6tryptophan catabolic process (GO:0006569)5.82565889
7indole-containing compound catabolic process (GO:0042436)5.82565889
8indolalkylamine catabolic process (GO:0046218)5.82565889
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.79004223
10glyoxylate metabolic process (GO:0046487)5.71440546
11cysteine metabolic process (GO:0006534)5.66406188
12kynurenine metabolic process (GO:0070189)5.54871421
13tryptophan metabolic process (GO:0006568)5.47041420
14sulfur amino acid catabolic process (GO:0000098)5.34481935
15protein-lipid complex assembly (GO:0065005)5.28050428
16urea metabolic process (GO:0019627)5.26199981
17urea cycle (GO:0000050)5.26199981
18bile acid biosynthetic process (GO:0006699)5.19604148
19serine family amino acid catabolic process (GO:0009071)5.08040443
20high-density lipoprotein particle remodeling (GO:0034375)5.00326279
21epoxygenase P450 pathway (GO:0019373)5.00019690
22homocysteine metabolic process (GO:0050667)4.98520834
23alpha-linolenic acid metabolic process (GO:0036109)4.97942791
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90199602
25lysine catabolic process (GO:0006554)4.88789937
26lysine metabolic process (GO:0006553)4.88789937
27nitrogen cycle metabolic process (GO:0071941)4.86775903
28intestinal absorption (GO:0050892)4.86080597
29aromatic amino acid family metabolic process (GO:0009072)4.85874956
30amino-acid betaine metabolic process (GO:0006577)4.69215801
31regulation of triglyceride catabolic process (GO:0010896)4.63194199
32negative regulation of fibrinolysis (GO:0051918)4.63181871
33regulation of cholesterol esterification (GO:0010872)4.58172303
34plasma lipoprotein particle organization (GO:0071827)4.56298754
35bile acid metabolic process (GO:0008206)4.54171504
36proline metabolic process (GO:0006560)4.51389185
37negative regulation of sterol transport (GO:0032372)4.48635836
38negative regulation of cholesterol transport (GO:0032375)4.48635836
39low-density lipoprotein particle remodeling (GO:0034374)4.45796102
40drug catabolic process (GO:0042737)4.45327714
41regulation of protein activation cascade (GO:2000257)4.44453655
42peptidyl-glutamic acid carboxylation (GO:0017187)4.42122927
43protein carboxylation (GO:0018214)4.42122927
44alpha-amino acid catabolic process (GO:1901606)4.40075510
45regulation of fibrinolysis (GO:0051917)4.39981693
46glycine metabolic process (GO:0006544)4.39528020
47serine family amino acid metabolic process (GO:0009069)4.39152808
48reverse cholesterol transport (GO:0043691)4.37775079
49complement activation, alternative pathway (GO:0006957)4.37317413
50serine family amino acid biosynthetic process (GO:0009070)4.34230236
51tyrosine metabolic process (GO:0006570)4.34147696
52drug transmembrane transport (GO:0006855)4.33647553
53regulation of apoptotic cell clearance (GO:2000425)4.32755505
54regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.32544252
55cellular ketone body metabolic process (GO:0046950)4.32460651
56blood coagulation, intrinsic pathway (GO:0007597)4.28613795
57urate metabolic process (GO:0046415)4.27112102
58plasma lipoprotein particle remodeling (GO:0034369)4.24690956
59protein-lipid complex remodeling (GO:0034368)4.24690956
60macromolecular complex remodeling (GO:0034367)4.24690956
61phospholipid efflux (GO:0033700)4.23915978
62protein-lipid complex subunit organization (GO:0071825)4.22303270
63bile acid and bile salt transport (GO:0015721)4.21498763
64triglyceride homeostasis (GO:0070328)4.19795371
65acylglycerol homeostasis (GO:0055090)4.19795371
66regulation of complement activation (GO:0030449)4.15198049
67cellular amino acid catabolic process (GO:0009063)4.14092848
68indolalkylamine metabolic process (GO:0006586)4.09105111
69regulation of plasminogen activation (GO:0010755)4.08409651
70ethanol oxidation (GO:0006069)4.06820028
71cellular modified amino acid catabolic process (GO:0042219)4.05633123
72drug transport (GO:0015893)3.99836882
73cellular biogenic amine catabolic process (GO:0042402)3.98752299
74amine catabolic process (GO:0009310)3.98752299
75glutamate metabolic process (GO:0006536)3.98010005
76proline biosynthetic process (GO:0006561)3.97458281
77cellular glucuronidation (GO:0052695)3.92517443
78arginine metabolic process (GO:0006525)3.90492096
79ketone body metabolic process (GO:1902224)3.87943554
80benzene-containing compound metabolic process (GO:0042537)3.87015764
81short-chain fatty acid metabolic process (GO:0046459)3.83887054
82plasma lipoprotein particle clearance (GO:0034381)3.82967252
83positive regulation of lipoprotein lipase activity (GO:0051006)3.80427817
84positive regulation of triglyceride lipase activity (GO:0061365)3.80427817
85cholesterol efflux (GO:0033344)3.80320257
86coenzyme catabolic process (GO:0009109)3.79727158
87heme transport (GO:0015886)3.79688889
88flavonoid metabolic process (GO:0009812)3.76915487
89plasma lipoprotein particle assembly (GO:0034377)3.75588908
90intestinal cholesterol absorption (GO:0030299)3.74651867
91regulation of bile acid biosynthetic process (GO:0070857)3.73505299
92imidazole-containing compound metabolic process (GO:0052803)3.73427522
93exogenous drug catabolic process (GO:0042738)3.73232435
94organic acid catabolic process (GO:0016054)3.70905053
95carboxylic acid catabolic process (GO:0046395)3.70905053
96cholesterol homeostasis (GO:0042632)3.70662533
97aldehyde catabolic process (GO:0046185)3.70567681
98lipoprotein metabolic process (GO:0042157)3.67504768
99sterol homeostasis (GO:0055092)3.66354121
100L-ascorbic acid metabolic process (GO:0019852)3.63097175
101regulation of cholesterol homeostasis (GO:2000188)3.62567525
102fibrinolysis (GO:0042730)3.62302801
103fructose metabolic process (GO:0006000)3.58980360
104carnitine metabolic process (GO:0009437)3.58817770
105phospholipid homeostasis (GO:0055091)3.57631625
106uronic acid metabolic process (GO:0006063)3.56289782
107glucuronate metabolic process (GO:0019585)3.56289782
108acetyl-CoA metabolic process (GO:0006084)3.55751249
109fatty acid beta-oxidation (GO:0006635)3.53931608
110fatty acid oxidation (GO:0019395)3.52361777
111ethanol metabolic process (GO:0006067)3.49156434
112fat-soluble vitamin biosynthetic process (GO:0042362)3.48206770
1132-oxoglutarate metabolic process (GO:0006103)3.46913585
114very-low-density lipoprotein particle assembly (GO:0034379)3.46788120
115negative regulation of protein activation cascade (GO:2000258)3.45448832
116aspartate family amino acid catabolic process (GO:0009068)3.44883434
117lipid oxidation (GO:0034440)3.44388762
118regulation of cholesterol biosynthetic process (GO:0045540)3.44279658
119drug metabolic process (GO:0017144)3.43767067
120vitamin transmembrane transport (GO:0035461)3.42986090
121negative regulation of hemostasis (GO:1900047)3.40641408
122negative regulation of blood coagulation (GO:0030195)3.40641408
123diacylglycerol metabolic process (GO:0046339)3.38970458
124omega-hydroxylase P450 pathway (GO:0097267)3.36848234
125negative regulation of lipase activity (GO:0060192)3.33936205
126NADH metabolic process (GO:0006734)3.33451919
127glutamine family amino acid biosynthetic process (GO:0009084)3.33367584
128regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.29588373
129renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.29306462
130positive regulation of fatty acid biosynthetic process (GO:0045723)3.28501017
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.28088182
132L-alpha-amino acid transmembrane transport (GO:1902475)3.27750373
133angiotensin maturation (GO:0002003)3.19365745
134phosphate ion homeostasis (GO:0055062)3.19097604
135trivalent inorganic anion homeostasis (GO:0072506)3.19097604
136regulation of cholesterol metabolic process (GO:0090181)3.18161929
137negative regulation of coagulation (GO:0050819)3.16203624
138positive regulation of cellular amine metabolic process (GO:0033240)3.16063109
139acute-phase response (GO:0006953)3.15604202
140protein activation cascade (GO:0072376)3.07847373
141positive regulation of steroid metabolic process (GO:0045940)3.06613342
142negative regulation of wound healing (GO:0061045)3.04264411
143sterol transport (GO:0015918)3.03477401
144cholesterol transport (GO:0030301)3.03477401
145positive regulation of hormone metabolic process (GO:0032352)3.00658142
146lipid homeostasis (GO:0055088)3.00481448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.47124145
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.64190488
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.10108188
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.65712145
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95788295
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.71389492
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.54055246
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.62816678
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.21848217
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.67399891
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10613736
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.10230191
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05868626
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00263602
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00263602
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00263602
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6618440
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90962602
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89200132
20* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83805088
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80570953
22GATA1_22025678_ChIP-Seq_K562_Human1.66344199
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57992863
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56920622
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.55304717
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53558040
27ZNF263_19887448_ChIP-Seq_K562_Human1.48955068
28CLOCK_20551151_ChIP-Seq_293T_Human1.45580631
29* GATA4_25053715_ChIP-Seq_YYC3_Human1.43084679
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42947959
31* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42563235
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41358015
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38332429
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.37159012
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36836483
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.31093198
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28429830
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.26667252
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25864435
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21036054
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20504004
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.19807317
43POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19118193
44TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17179097
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16811579
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16727227
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.15897931
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.11324179
49RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10449596
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08142625
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07060490
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03266301
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03153909
54FOXA1_25552417_ChIP-Seq_VCAP_Human1.03133933
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.02966223
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.01152012
57GATA6_25053715_ChIP-Seq_YYC3_Human1.00012647
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99241447
59TCF4_18268006_ChIP-ChIP_LS174T_Human0.98735973
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98192663
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98119374
62HTT_18923047_ChIP-ChIP_STHdh_Human0.97356842
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96266095
64EOMES_21245162_ChIP-Seq_HESCs_Human0.95806515
65* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94241512
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94173888
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93904647
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93235019
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92365619
70IRF8_22096565_ChIP-ChIP_GC-B_Human0.92096548
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91650683
72ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91627239
73SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91221313
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89584464
75AR_21909140_ChIP-Seq_LNCAP_Human0.89436749
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89263388
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89014950
78* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88931302
79KAP1_27257070_Chip-Seq_ESCs_Mouse0.88555794
80NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88254824
81KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86179477
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85256375
83RARA_24833708_ChIP-Seq_LIVER_Mouse0.84825251
84* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84605674
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84305029
86* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82194834
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81529707
88ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78831392
89RACK7_27058665_Chip-Seq_MCF-7_Human0.77374603
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76992887
91* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76903188
92LXR_22292898_ChIP-Seq_THP-1_Human0.73261685
93RARB_24833708_ChIP-Seq_LIVER_Mouse0.71849847
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70880870
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69969215
96SOX2_20726797_ChIP-Seq_SW620_Human0.69850261
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69312096
98* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67244965
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66261930
100* ATF3_27146783_Chip-Seq_COLON_Human0.66225052
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.65883391
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.65644294
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64636482
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64578284
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.64562613
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63459406
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.62997225
108CEBPB_22108803_ChIP-Seq_LS180_Human0.62656917
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62569358
110ELF1_17652178_ChIP-ChIP_JURKAT_Human0.62405632
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.62214487
112AR_20517297_ChIP-Seq_VCAP_Human0.61401293
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61145939
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.61115184
115* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61052607
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60854051
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.59164520
118BCOR_27268052_Chip-Seq_Bcells_Human0.58116982
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.57846224
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57721808
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.56475324
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.56423657
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.56135501
124* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.55690909
125EGR1_19032775_ChIP-ChIP_M12_Human0.55296299
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.54849749
127* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.53802134
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.53712018
129CREB1_15753290_ChIP-ChIP_HEK293T_Human0.52862266
130* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.52771850
131TAF2_19829295_ChIP-Seq_ESCs_Human0.51990831
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.51819753
133* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51041604
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.51000373
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50468387
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49981002
137BCL6_27268052_Chip-Seq_Bcells_Human0.49609093
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48228870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.99468340
2MP0002139_abnormal_hepatobiliary_system7.66432619
3MP0005085_abnormal_gallbladder_physiolo5.76161673
4MP0005365_abnormal_bile_salt5.41713515
5MP0008875_abnormal_xenobiotic_pharmacok4.83273440
6MP0003806_abnormal_nucleotide_metabolis4.06999434
7MP0009840_abnormal_foam_cell3.92044207
8MP0003252_abnormal_bile_duct3.52751050
9MP0010329_abnormal_lipoprotein_level3.29638014
10MP0005332_abnormal_amino_acid3.10975604
11MP0003195_calcinosis3.05320307
12MP0001666_abnormal_nutrient_absorption2.94576732
13MP0004019_abnormal_vitamin_homeostasis2.89592252
14MP0003122_maternal_imprinting2.78753148
15MP0005083_abnormal_biliary_tract2.44837968
16MP0000566_synostosis2.29123176
17MP0003283_abnormal_digestive_organ2.19398688
18MP0003191_abnormal_cellular_cholesterol2.19240435
19MP0003941_abnormal_skin_development1.97998530
20MP0000609_abnormal_liver_physiology1.96532435
21MP0002138_abnormal_hepatobiliary_system1.94448231
22MP0002118_abnormal_lipid_homeostasis1.92855414
23MP0005319_abnormal_enzyme/_coenzyme1.87034653
24MP0003123_paternal_imprinting1.81824431
25MP0009643_abnormal_urine_homeostasis1.81735801
26MP0001764_abnormal_homeostasis1.78267663
27MP0005451_abnormal_body_composition1.60157119
28MP0000678_abnormal_parathyroid_gland1.53861334
29MP0003186_abnormal_redox_activity1.53302947
30MP0004133_heterotaxia1.51890012
31MP0005584_abnormal_enzyme/coenzyme_acti1.51095452
32MP0003868_abnormal_feces_composition1.46750790
33MP0003878_abnormal_ear_physiology1.45291244
34MP0005377_hearing/vestibular/ear_phenot1.45291244
35MP0009697_abnormal_copulation1.34464332
36MP0005636_abnormal_mineral_homeostasis1.33748931
37MP0005257_abnormal_intraocular_pressure1.31498837
38MP0003890_abnormal_embryonic-extraembry1.30319475
39MP0004272_abnormal_basement_membrane1.27679293
40MP0002909_abnormal_adrenal_gland1.25933767
41MP0003136_yellow_coat_color1.24210178
42MP0005409_darkened_coat_color1.22425311
43MP0001756_abnormal_urination1.17148221
44MP0003183_abnormal_peptide_metabolism1.17036439
45MP0000598_abnormal_liver_morphology1.16987809
46MP0009672_abnormal_birth_weight1.12270896
47MP0003011_delayed_dark_adaptation1.10514384
48MP0004043_abnormal_pH_regulation1.10009085
49MP0003705_abnormal_hypodermis_morpholog1.07183101
50MP0002876_abnormal_thyroid_physiology1.06758771
51MP0006036_abnormal_mitochondrial_physio1.06688589
52MP0009780_abnormal_chondrocyte_physiolo1.06594034
53MP0005408_hypopigmentation1.06059997
54MP0004264_abnormal_extraembryonic_tissu1.05046434
55MP0003119_abnormal_digestive_system1.01447608
56MP0003567_abnormal_fetal_cardiomyocyte0.96980059
57MP0002938_white_spotting0.96870454
58MP0005084_abnormal_gallbladder_morpholo0.96407695
59MP0003656_abnormal_erythrocyte_physiolo0.95833968
60MP0001915_intracranial_hemorrhage0.92817081
61MP0009764_decreased_sensitivity_to0.91084059
62MP0010234_abnormal_vibrissa_follicle0.91003593
63MP0008469_abnormal_protein_level0.90698239
64MP0009642_abnormal_blood_homeostasis0.90537180
65MP0002136_abnormal_kidney_physiology0.89927762
66MP0000462_abnormal_digestive_system0.88372368
67MP0009763_increased_sensitivity_to0.85963960
68MP0009384_cardiac_valve_regurgitation0.83240252
69MP0003718_maternal_effect0.81611931
70MP0010030_abnormal_orbit_morphology0.79087050
71MP0001765_abnormal_ion_homeostasis0.79057540
72MP0002254_reproductive_system_inflammat0.78716689
73MP0005647_abnormal_sex_gland0.78174145
74MP0004782_abnormal_surfactant_physiolog0.76619240
75MP0005376_homeostasis/metabolism_phenot0.76549123
76MP0000604_amyloidosis0.76172901
77MP0005670_abnormal_white_adipose0.75720396
78MP0009765_abnormal_xenobiotic_induced0.74852827
79MP0001730_embryonic_growth_arrest0.74461601
80MP0003121_genomic_imprinting0.73596046
81MP0004858_abnormal_nervous_system0.72959673
82MP0002796_impaired_skin_barrier0.70639440
83MP0002697_abnormal_eye_size0.69740293
84MP0005220_abnormal_exocrine_pancreas0.67253062
85MP0002078_abnormal_glucose_homeostasis0.66750990
86MP0006035_abnormal_mitochondrial_morpho0.65471942
87MP0003693_abnormal_embryo_hatching0.65223857
88MP0003172_abnormal_lysosome_physiology0.64614810
89MP0003566_abnormal_cell_adhesion0.64319069
90MP0005395_other_phenotype0.63029046
91MP0005266_abnormal_metabolism0.62179270
92MP0000537_abnormal_urethra_morphology0.61633718
93MP0010368_abnormal_lymphatic_system0.61593768
94MP0003115_abnormal_respiratory_system0.59006253
95MP0005058_abnormal_lysosome_morphology0.57932856
96MP0003315_abnormal_perineum_morphology0.57643814
97MP0003937_abnormal_limbs/digits/tail_de0.57427255
98MP0005076_abnormal_cell_differentiation0.57182872
99MP0005379_endocrine/exocrine_gland_phen0.56274471
100MP0005334_abnormal_fat_pad0.55325984
101MP0003638_abnormal_response/metabolism_0.54859148
102MP0002086_abnormal_extraembryonic_tissu0.54833292
103MP0004270_analgesia0.54414795
104MP0002971_abnormal_brown_adipose0.53579598
105MP0005464_abnormal_platelet_physiology0.52992704
106MP0001849_ear_inflammation0.52351319
107MP0004957_abnormal_blastocyst_morpholog0.51923217
108MP0004381_abnormal_hair_follicle0.51918090
109MP0009053_abnormal_anal_canal0.51409310
110MP0005535_abnormal_body_temperature0.51386715
111MP0001672_abnormal_embryogenesis/_devel0.51262582
112MP0005380_embryogenesis_phenotype0.51262582
113MP0009379_abnormal_foot_pigmentation0.51181901
114MP0010352_gastrointestinal_tract_polyps0.50323801
115MP0002111_abnormal_tail_morphology0.49809051
116MP0004147_increased_porphyrin_level0.49416335
117MP0005166_decreased_susceptibility_to0.45333908
118MP0001661_extended_life_span0.45121445
119MP0008872_abnormal_physiological_respon0.43792793
120MP0005448_abnormal_energy_balance0.43409112
121MP0003329_amyloid_beta_deposits0.42873426
122MP0005666_abnormal_adipose_tissue0.42434080
123MP0003953_abnormal_hormone_level0.42166908
124MP0004130_abnormal_muscle_cell0.41826655
125MP0001881_abnormal_mammary_gland0.41755546
126MP0008873_increased_physiological_sensi0.41683981
127MP0003300_gastrointestinal_ulcer0.41168592
128MP0005075_abnormal_melanosome_morpholog0.40094657
129MP0002135_abnormal_kidney_morphology0.38929352
130MP0002098_abnormal_vibrissa_morphology0.38020536
131MP0000538_abnormal_urinary_bladder0.36537313
132MP0000477_abnormal_intestine_morphology0.36385244
133MP0010155_abnormal_intestine_physiology0.36033464
134MP0005501_abnormal_skin_physiology0.35347808
135MP0001845_abnormal_inflammatory_respons0.34960705
136MP0000230_abnormal_systemic_arterial0.34681172
137MP0002168_other_aberrant_phenotype0.33316791
138MP0000639_abnormal_adrenal_gland0.33003631
139MP0003724_increased_susceptibility_to0.30614448
140MP0001663_abnormal_digestive_system0.29502136
141MP0000377_abnormal_hair_follicle0.28951060
142MP0002132_abnormal_respiratory_system0.28365758
143MP0002060_abnormal_skin_morphology0.28205745
144MP0000249_abnormal_blood_vessel0.27681855
145MP0002970_abnormal_white_adipose0.27529266
146MP0002089_abnormal_postnatal_growth/wei0.26907900

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.69409064
2Intrahepatic cholestasis (HP:0001406)6.32413961
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.09310344
4Deep venous thrombosis (HP:0002625)5.85080062
5Hypobetalipoproteinemia (HP:0003563)5.78549798
6Xanthomatosis (HP:0000991)5.67702895
7Prolonged partial thromboplastin time (HP:0003645)5.04493487
8Hyperlipoproteinemia (HP:0010980)4.96026180
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.82391832
10Hyperglycinuria (HP:0003108)4.73965290
11Hyperammonemia (HP:0001987)4.66964167
12Hyperglycinemia (HP:0002154)4.46565183
13Abnormality of serine family amino acid metabolism (HP:0010894)4.41005509
14Abnormality of glycine metabolism (HP:0010895)4.41005509
15Hypolipoproteinemia (HP:0010981)4.37920394
16Glomerulonephritis (HP:0000099)4.32235067
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12457407
18Ketosis (HP:0001946)4.11989651
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.06909603
20Complement deficiency (HP:0004431)4.02121483
21Abnormality of fatty-acid metabolism (HP:0004359)4.00045229
22Hypoglycemic coma (HP:0001325)3.98227190
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.92081728
24Fat malabsorption (HP:0002630)3.91154060
25Joint hemorrhage (HP:0005261)3.78391773
26Hypoalphalipoproteinemia (HP:0003233)3.73602627
27Conjugated hyperbilirubinemia (HP:0002908)3.63944200
28Abnormality of pyrimidine metabolism (HP:0004353)3.61226021
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.56025973
30Abnormality of methionine metabolism (HP:0010901)3.55221267
31Gout (HP:0001997)3.54938120
32Epidermoid cyst (HP:0200040)3.48068025
33Abnormality of the common coagulation pathway (HP:0010990)3.43296953
34Hemorrhage of the eye (HP:0011885)3.41216043
35Abnormality of nucleobase metabolism (HP:0010932)3.34277793
36Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23575078
37Dicarboxylic aciduria (HP:0003215)3.23575078
38Abnormality of purine metabolism (HP:0004352)3.20803679
39Ketoacidosis (HP:0001993)3.16862682
40Abnormality of serum amino acid levels (HP:0003112)3.15931561
41Abnormality of the intrinsic pathway (HP:0010989)3.12875406
42Delayed CNS myelination (HP:0002188)3.04196302
43Proximal tubulopathy (HP:0000114)3.01708787
44Hypercholesterolemia (HP:0003124)3.01391995
45Hyperbilirubinemia (HP:0002904)3.01217194
46Generalized aminoaciduria (HP:0002909)2.99223256
47Lethargy (HP:0001254)2.98792039
48Metabolic acidosis (HP:0001942)2.95790862
49Malnutrition (HP:0004395)2.91313751
50Abnormality of complement system (HP:0005339)2.90320032
51Hepatoblastoma (HP:0002884)2.89427432
52Steatorrhea (HP:0002570)2.83586780
53Flat acetabular roof (HP:0003180)2.81717888
54Glycosuria (HP:0003076)2.70961982
55Abnormality of urine glucose concentration (HP:0011016)2.70961982
56Hepatocellular carcinoma (HP:0001402)2.67776952
57Spontaneous abortion (HP:0005268)2.64100835
58Ileus (HP:0002595)2.63210701
59Vaginal fistula (HP:0004320)2.61565723
60Vascular calcification (HP:0004934)2.59873486
61Alkalosis (HP:0001948)2.54316997
62Nephritis (HP:0000123)2.53318117
63Irritability (HP:0000737)2.47083355
64Widely patent fontanelles and sutures (HP:0004492)2.45326053
65Vomiting (HP:0002013)2.45137686
66Increased purine levels (HP:0004368)2.40539374
67Hyperuricemia (HP:0002149)2.40539374
68Hydroxyprolinuria (HP:0003080)2.39669331
69Abnormality of proline metabolism (HP:0010907)2.39669331
70Cerebral edema (HP:0002181)2.38632503
71Spastic diplegia (HP:0001264)2.34382578
72Acanthocytosis (HP:0001927)2.34352225
73Abnormal tarsal ossification (HP:0008369)2.33672303
74Esophageal varix (HP:0002040)2.33106880
75Hypophosphatemic rickets (HP:0004912)2.30605519
76Abnormality of carpal bone ossification (HP:0006257)2.30526297
77Myocardial infarction (HP:0001658)2.25892821
78Bifid scrotum (HP:0000048)2.25807931
79Cardiovascular calcification (HP:0011915)2.25593555
80Pancreatitis (HP:0001733)2.23044709
81Nausea (HP:0002018)2.22909772
82Asymmetry of the thorax (HP:0001555)2.21787986
83Neonatal onset (HP:0003623)2.21147691
84Late onset (HP:0003584)2.20327795
85Alacrima (HP:0000522)2.20252857
86Pancreatic islet-cell hyperplasia (HP:0004510)2.19179365
87Hypoglycemic seizures (HP:0002173)2.18306124
88Facial shape deformation (HP:0011334)2.17705419
89Potter facies (HP:0002009)2.17705419
90Osteomalacia (HP:0002749)2.16496535
91Bronchomalacia (HP:0002780)2.16198122
92Systemic lupus erythematosus (HP:0002725)2.15336113
93Small epiphyses (HP:0010585)2.14478776
94Skin nodule (HP:0200036)2.11687867
95Hypochromic microcytic anemia (HP:0004840)2.11223698
96Rickets (HP:0002748)2.10938374
97Abnormality of vitamin metabolism (HP:0100508)2.10197851
98Broad alveolar ridges (HP:0000187)2.09691697
99Brushfield spots (HP:0001088)2.09027102
100Pigmentary retinal degeneration (HP:0001146)2.08034736
101Right ventricular cardiomyopathy (HP:0011663)2.03219493
102Gingival bleeding (HP:0000225)1.99478617
103Hyperphosphaturia (HP:0003109)1.99365921
104Anal stenosis (HP:0002025)1.98867209
105Confusion (HP:0001289)1.98737875
106Abnormal enzyme/coenzyme activity (HP:0012379)1.98087263
107Megaloblastic anemia (HP:0001889)1.98050623
108Sensorimotor neuropathy (HP:0007141)1.97729469
109Nephrolithiasis (HP:0000787)1.97379455
110Menorrhagia (HP:0000132)1.96727920
111Abnormality of the nasal septum (HP:0000419)1.96276686
112Abnormal cartilage morphology (HP:0002763)1.94313088
113Amyloidosis (HP:0011034)1.94283266
114Renal cortical cysts (HP:0000803)1.94208339
115Opisthotonus (HP:0002179)1.93473019
116Abnormal urine phosphate concentration (HP:0012599)1.92551773
117Abnormality of transition element cation homeostasis (HP:0011030)1.92199638
118Abnormality of the lacrimal duct (HP:0011481)1.91809590
119Hepatic necrosis (HP:0002605)1.91214149
120Choanal stenosis (HP:0000452)1.90143714
121Cholelithiasis (HP:0001081)1.89697329
122Enlarged kidneys (HP:0000105)1.89473995
123Abnormal gallbladder morphology (HP:0012437)1.88921101
124Wide cranial sutures (HP:0010537)1.86281634
125Poikilocytosis (HP:0004447)1.82756322
126Abnormality of iron homeostasis (HP:0011031)1.79101386
127Abnormality of alkaline phosphatase activity (HP:0004379)1.78396362
128Abnormal gallbladder physiology (HP:0012438)1.77194986
129Mitral stenosis (HP:0001718)1.75937576
130Absent eyebrow (HP:0002223)1.73845225
131Hypotension (HP:0002615)1.70655609
132Symptomatic seizures (HP:0011145)1.70525402
133Hypophosphatemia (HP:0002148)1.69540559
134Hyperinsulinemic hypoglycemia (HP:0000825)1.67814666
135Increased serum pyruvate (HP:0003542)1.63665998
136Abnormality of endocrine pancreas physiology (HP:0012093)1.63083435
137Abnormality of the pancreatic islet cells (HP:0006476)1.63083435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.64747662
2EPHA24.87738838
3ERN13.46070307
4FGFR43.38633874
5MST1R2.86378429
6FGFR32.67430710
7ICK2.66531384
8SIK12.62226695
9FGFR22.54324354
10EEF2K2.45377569
11MAP3K32.15639649
12PKN22.15436256
13TAOK32.12170392
14STK38L2.01406087
15FGFR11.95362085
16SMG11.95157748
17TRIB31.95044439
18MAP2K31.83274488
19CDK121.81732892
20TYRO31.79778780
21NEK91.78314081
22FRK1.70755525
23INSRR1.67209266
24NME21.61894423
25PIK3CA1.58589130
26GRK61.58322893
27FLT31.55625320
28PDGFRA1.55093101
29WEE11.51971507
30MAPK111.47701346
31IRAK31.45987528
32STK161.45359224
33MAP2K21.43894563
34MAP2K61.38295755
35WNK41.36674438
36PBK1.36093912
37ERBB41.32472463
38PTK61.32292815
39KDR1.29004553
40MAP3K111.28269386
41WNK31.25525153
42RPS6KB21.19644522
43ABL21.16662478
44TTK1.12827213
45MET1.10636381
46OXSR11.07966836
47BRSK21.05624077
48CDK71.04177917
49RIPK10.99891211
50TYK20.99571766
51TBK10.98264052
52PIK3CG0.94673588
53FER0.94495381
54TIE10.93056220
55ACVR1B0.88908484
56LATS20.88397904
57PDK30.86607463
58PDK40.86607463
59PRKG20.85285571
60MAP3K120.84065076
61BCR0.81712150
62NEK10.81350390
63PTK20.81146579
64TNIK0.80063078
65LATS10.79259187
66STK390.77510814
67LMTK20.75845938
68RET0.74912833
69NEK60.74282004
70EPHA30.74107074
71CSNK1E0.73312828
72MAP2K40.72425673
73ERBB20.71366539
74DAPK20.70933270
75PRKAA20.70493875
76PINK10.69952510
77MAP3K90.69559473
78LRRK20.69342002
79CDK40.68959049
80MYLK0.67921231
81SCYL20.67550643
82MTOR0.66896064
83NME10.65463139
84SGK30.65046352
85EPHB10.64788400
86CAMK2G0.63662212
87NLK0.63416917
88PIM20.62832282
89GSK3A0.59912467
90MAP3K70.59897134
91PRKCZ0.58280914
92RPS6KB10.57210236
93JAK20.55680788
94MAP3K100.55043368
95CDK60.51577468
96TSSK60.51162134
97MAPK40.50938667
98VRK20.49909604
99SGK20.49785799
100DAPK10.48323610
101CDC42BPA0.47784031
102MAPK150.47516444
103STK240.47435301
104TAOK20.46943486
105BMX0.46926918
106TGFBR20.46280601
107ZAP700.46159272
108MST40.46130339
109MAP2K10.43557128
110CAMK1D0.43035839
111PAK40.42599824
112NUAK10.42553982
113SGK2230.42270303
114SGK4940.42270303
115DDR20.42169756
116PDPK10.41744671
117ALK0.41635704
118PRKAA10.41495872
119CSNK1G10.41481006
120BRD40.41271676
121PDK20.40551228
122DYRK1B0.39503661
123YES10.39338279
124NEK20.38311141
125BUB10.38166934
126AKT30.37741717
127STK30.37512989
128PLK30.37480735
129PRKCI0.37050419
130AKT20.36293842
131PDK10.35794815
132MAP3K80.35455654
133PRKACG0.35408696
134MATK0.34334754
135CSNK1A10.34332592
136SRPK10.33756457
137CSNK1D0.32813882
138MAPKAPK30.32403549
139EIF2AK10.32370905
140TAOK10.31369978
141CSNK2A20.31243184
142PIM10.30839291
143CSNK2A10.30787880
144MAP3K20.30573424
145MAP4K10.30527106
146BTK0.30384212
147SRC0.29645260
148MUSK0.26719765

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.84089981
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34611508
3Nitrogen metabolism_Homo sapiens_hsa009103.01861896
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84424968
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80398275
6Arginine biosynthesis_Homo sapiens_hsa002202.79115343
7Tryptophan metabolism_Homo sapiens_hsa003802.61405327
8Fatty acid degradation_Homo sapiens_hsa000712.55011377
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49698961
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49045309
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49028540
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31176533
13Complement and coagulation cascades_Homo sapiens_hsa046102.19240455
14Peroxisome_Homo sapiens_hsa041462.15288454
15Butanoate metabolism_Homo sapiens_hsa006502.14228825
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08906580
17Propanoate metabolism_Homo sapiens_hsa006402.05010620
18Histidine metabolism_Homo sapiens_hsa003402.02792759
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93563988
20Chemical carcinogenesis_Homo sapiens_hsa052041.87818036
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84178781
22Caffeine metabolism_Homo sapiens_hsa002321.84003407
23beta-Alanine metabolism_Homo sapiens_hsa004101.83875637
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.82772550
25PPAR signaling pathway_Homo sapiens_hsa033201.77350688
26Fatty acid metabolism_Homo sapiens_hsa012121.71950796
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71581467
28Folate biosynthesis_Homo sapiens_hsa007901.69616386
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66073622
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.64117490
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.63142746
32Sulfur metabolism_Homo sapiens_hsa009201.60613170
33Selenocompound metabolism_Homo sapiens_hsa004501.59724661
34Retinol metabolism_Homo sapiens_hsa008301.57931708
35Fat digestion and absorption_Homo sapiens_hsa049751.53518786
36Bile secretion_Homo sapiens_hsa049761.49484456
37Vitamin digestion and absorption_Homo sapiens_hsa049771.48246243
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45980213
39Pyruvate metabolism_Homo sapiens_hsa006201.45428587
40Phenylalanine metabolism_Homo sapiens_hsa003601.40391702
41Carbon metabolism_Homo sapiens_hsa012001.37568240
42Starch and sucrose metabolism_Homo sapiens_hsa005001.34625402
43Tyrosine metabolism_Homo sapiens_hsa003501.32837579
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.31528294
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30430711
46Biosynthesis of amino acids_Homo sapiens_hsa012301.26323777
47Staphylococcus aureus infection_Homo sapiens_hsa051501.23929484
48Fatty acid elongation_Homo sapiens_hsa000621.19439909
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.17590572
50Arginine and proline metabolism_Homo sapiens_hsa003301.13923350
51Glutathione metabolism_Homo sapiens_hsa004801.13076808
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08469734
53ABC transporters_Homo sapiens_hsa020101.05384947
54Sulfur relay system_Homo sapiens_hsa041221.03827318
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01376093
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99064830
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97268724
58Steroid biosynthesis_Homo sapiens_hsa001000.96299606
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94400486
60Pentose phosphate pathway_Homo sapiens_hsa000300.92284792
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88482223
62One carbon pool by folate_Homo sapiens_hsa006700.88237612
63Vitamin B6 metabolism_Homo sapiens_hsa007500.86982312
64Fructose and mannose metabolism_Homo sapiens_hsa000510.78453239
65Glycerolipid metabolism_Homo sapiens_hsa005610.75480582
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74800067
67Galactose metabolism_Homo sapiens_hsa000520.69666456
68Lysine degradation_Homo sapiens_hsa003100.69094519
69Metabolic pathways_Homo sapiens_hsa011000.60612483
70N-Glycan biosynthesis_Homo sapiens_hsa005100.56040846
71Sphingolipid metabolism_Homo sapiens_hsa006000.54668220
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40600455
73Tight junction_Homo sapiens_hsa045300.38225241
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33256655
75Renin-angiotensin system_Homo sapiens_hsa046140.30082832
76Linoleic acid metabolism_Homo sapiens_hsa005910.26153226
77Fatty acid biosynthesis_Homo sapiens_hsa000610.25171393
78Mineral absorption_Homo sapiens_hsa049780.24265053
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23728901
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.21818085
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.21619390
82Ether lipid metabolism_Homo sapiens_hsa005650.19175938
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18078757
84Adherens junction_Homo sapiens_hsa045200.17460221
85Insulin resistance_Homo sapiens_hsa049310.16339205
86Arachidonic acid metabolism_Homo sapiens_hsa005900.15346378
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15240855
88Thyroid cancer_Homo sapiens_hsa052160.15237074
89TGF-beta signaling pathway_Homo sapiens_hsa043500.13159694
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.11374985
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10911582
92Regulation of autophagy_Homo sapiens_hsa041400.10531089
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.06785007
94Pyrimidine metabolism_Homo sapiens_hsa002400.04610298
95Prion diseases_Homo sapiens_hsa050200.03347108
96Proteasome_Homo sapiens_hsa030500.01626623
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00553123
98AMPK signaling pathway_Homo sapiens_hsa041520.00361044
99Insulin signaling pathway_Homo sapiens_hsa04910-0.1740242
100Parkinsons disease_Homo sapiens_hsa05012-0.1627190
101Lysosome_Homo sapiens_hsa04142-0.1506805
102Bladder cancer_Homo sapiens_hsa05219-0.1348731
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1282339
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1225031
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1140519
106Oxidative phosphorylation_Homo sapiens_hsa00190-0.1139872
107Hepatitis C_Homo sapiens_hsa05160-0.0991707
108Ribosome_Homo sapiens_hsa03010-0.0981610
109Other glycan degradation_Homo sapiens_hsa00511-0.0744028
110Glucagon signaling pathway_Homo sapiens_hsa04922-0.0645986
111Protein digestion and absorption_Homo sapiens_hsa04974-0.0027347

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