RAB19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.56439562
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.56439562
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.33292540
4antigen processing and presentation of endogenous antigen (GO:0019883)6.32057324
5leukocyte aggregation (GO:0070486)6.21302103
6negative thymic T cell selection (GO:0045060)6.01612851
7negative T cell selection (GO:0043383)5.96284516
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.79331590
9positive thymic T cell selection (GO:0045059)5.77864369
10regulation of B cell receptor signaling pathway (GO:0050855)5.69021337
11positive regulation of gamma-delta T cell activation (GO:0046645)5.36218589
12T cell migration (GO:0072678)5.21910007
13thymic T cell selection (GO:0045061)4.96287490
14response to type I interferon (GO:0034340)4.92533095
15cellular response to interleukin-15 (GO:0071350)4.86840656
16type I interferon signaling pathway (GO:0060337)4.86741109
17cellular response to type I interferon (GO:0071357)4.86741109
18sequestering of actin monomers (GO:0042989)4.84040097
19interferon-gamma production (GO:0032609)4.76639115
20positive T cell selection (GO:0043368)4.73562034
21protein maturation by protein folding (GO:0022417)4.55440717
22regulation of isotype switching to IgG isotypes (GO:0048302)4.52860706
23protein complex localization (GO:0031503)4.41178863
24T cell selection (GO:0045058)4.31386575
25L-serine metabolic process (GO:0006563)4.29488211
26regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.28004771
27response to interleukin-15 (GO:0070672)4.26025308
28regulation of gamma-delta T cell differentiation (GO:0045586)4.20058129
29cellular protein complex localization (GO:0034629)4.15730483
30antigen processing and presentation via MHC class Ib (GO:0002475)4.08368833
31T cell receptor signaling pathway (GO:0050852)4.08337543
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.01477102
33cellular response to interferon-beta (GO:0035458)4.00963155
34T cell costimulation (GO:0031295)3.99898297
35positive regulation of alpha-beta T cell proliferation (GO:0046641)3.99729578
36mast cell activation (GO:0045576)3.97980410
37intestinal cholesterol absorption (GO:0030299)3.97026333
38regulation of alpha-beta T cell proliferation (GO:0046640)3.95908808
39lymphocyte costimulation (GO:0031294)3.94541279
40negative regulation of execution phase of apoptosis (GO:1900118)3.92570409
41regulation of T cell receptor signaling pathway (GO:0050856)3.91873285
42NADH metabolic process (GO:0006734)3.91726000
43regulation of T cell tolerance induction (GO:0002664)3.90324363
44COPI coating of Golgi vesicle (GO:0048205)3.89355574
45Golgi transport vesicle coating (GO:0048200)3.89355574
46regulation of gamma-delta T cell activation (GO:0046643)3.85504093
47intestinal epithelial cell development (GO:0060576)3.83720513
48antigen receptor-mediated signaling pathway (GO:0050851)3.82379930
49positive regulation of lamellipodium assembly (GO:0010592)3.81340093
50regulation of response to interferon-gamma (GO:0060330)3.81229275
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.80103377
52Arp2/3 complex-mediated actin nucleation (GO:0034314)3.79121292
53negative regulation of cell killing (GO:0031342)3.75625796
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75625796
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.75175681
56immunoglobulin mediated immune response (GO:0016064)3.70043907
57regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.69302489
58regulation of type I interferon-mediated signaling pathway (GO:0060338)3.68493463
59interferon-gamma-mediated signaling pathway (GO:0060333)3.68250605
60positive regulation of interferon-alpha production (GO:0032727)3.66900439
61cellular response to zinc ion (GO:0071294)3.63226930
62regulation of interferon-alpha production (GO:0032647)3.50840864
63signal peptide processing (GO:0006465)3.47801876
64positive regulation of macrophage differentiation (GO:0045651)3.45916577
65regulation of respiratory burst (GO:0060263)3.41625614
66cellular response to interleukin-4 (GO:0071353)3.40766790
67leukocyte cell-cell adhesion (GO:0007159)3.39590137
68positive regulation of lamellipodium organization (GO:1902745)3.36922290
69B cell mediated immunity (GO:0019724)3.33066470
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.32002207
71regulation of B cell differentiation (GO:0045577)3.30920930
72B cell receptor signaling pathway (GO:0050853)3.28603927
73negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.28593182
74transcription from mitochondrial promoter (GO:0006390)3.27164488
75nucleoside diphosphate catabolic process (GO:0009134)3.26976680
76positive regulation of isotype switching (GO:0045830)3.26077730
77tolerance induction (GO:0002507)3.25840353
78L-alpha-amino acid transmembrane transport (GO:1902475)3.24271255
79proline biosynthetic process (GO:0006561)3.22636064
80histone H3-K36 demethylation (GO:0070544)3.21218012
81regulation of natural killer cell mediated immunity (GO:0002715)3.20728513
82regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.20728513
83positive regulation of natural killer cell mediated immunity (GO:0002717)3.17078545
84positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.17078545
85response to interferon-beta (GO:0035456)3.16779139
86ribosome assembly (GO:0042255)3.16438218
87cellular response to interferon-alpha (GO:0035457)3.15700826
88regulation of interferon-beta biosynthetic process (GO:0045357)3.13557520
89receptor recycling (GO:0001881)3.11229004
90regulation of translational fidelity (GO:0006450)3.09592939
91biotin metabolic process (GO:0006768)3.09021363
92dendritic cell chemotaxis (GO:0002407)3.07043647
93regulation of isotype switching (GO:0045191)3.04954128
94cellular extravasation (GO:0045123)3.04080581
95positive regulation of immunoglobulin mediated immune response (GO:0002891)3.03322045
96positive regulation of B cell mediated immunity (GO:0002714)3.03322045
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.02687677
98DNA deamination (GO:0045006)3.00648050
99lymphocyte migration (GO:0072676)2.99983155
100regulation of interleukin-2 biosynthetic process (GO:0045076)2.99726201
101regulation of immunoglobulin production (GO:0002637)2.99669766
102defense response to protozoan (GO:0042832)2.98135590
103regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97968775
104positive regulation of DNA recombination (GO:0045911)2.96837823
105positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.96526293
106regulation of immunoglobulin mediated immune response (GO:0002889)2.95597378
107response to protozoan (GO:0001562)2.95450524
108nuclear pore complex assembly (GO:0051292)2.95440834
109lymphocyte chemotaxis (GO:0048247)2.94932113
110positive regulation of interferon-gamma production (GO:0032729)2.94718317
111regulation of B cell mediated immunity (GO:0002712)2.93174913
112actin nucleation (GO:0045010)2.88052068
113regulation of T cell chemotaxis (GO:0010819)2.87471688
114positive regulation of T cell chemotaxis (GO:0010820)2.87471688
115positive regulation of interleukin-2 production (GO:0032743)2.87402016
116natural killer cell activation (GO:0030101)2.87079434
117immune response-activating cell surface receptor signaling pathway (GO:0002429)2.86410645
118hepatocyte apoptotic process (GO:0097284)2.85433745
119cellular defense response (GO:0006968)2.84702137
120respiratory burst (GO:0045730)2.82345392
121T cell activation (GO:0042110)2.80709987
122regulation of interleukin-12 biosynthetic process (GO:0045075)2.80548947
123branched-chain amino acid catabolic process (GO:0009083)2.80307641
124positive regulation of tolerance induction (GO:0002645)2.80243488
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80242351
126response to interleukin-4 (GO:0070670)2.78877421
127response to interferon-alpha (GO:0035455)2.78796462
128regulation of tolerance induction (GO:0002643)2.78641757
129regulation of water loss via skin (GO:0033561)2.73685476
130regulation of gene silencing by RNA (GO:0060966)2.69776421
131regulation of posttranscriptional gene silencing (GO:0060147)2.69776421
132regulation of gene silencing by miRNA (GO:0060964)2.69776421
133positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.66547090
134muscle atrophy (GO:0014889)2.65080374
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62684631
136COPII vesicle coating (GO:0048208)2.62448171
137determination of adult lifespan (GO:0008340)2.62429213
138regulation of cellular amino acid metabolic process (GO:0006521)2.62322613
139NADPH regeneration (GO:0006740)2.59816434
140serine family amino acid biosynthetic process (GO:0009070)2.59272425
141mitotic sister chromatid cohesion (GO:0007064)2.58441376
142cellular zinc ion homeostasis (GO:0006882)2.56268834
143intestinal absorption (GO:0050892)2.55815835
144protein K6-linked ubiquitination (GO:0085020)2.55502406
145proteasome assembly (GO:0043248)2.54223250
146very-low-density lipoprotein particle assembly (GO:0034379)2.53892690
147alpha-linolenic acid metabolic process (GO:0036109)2.52900895
148establishment of integrated proviral latency (GO:0075713)2.52076832
149positive regulation of epidermal cell differentiation (GO:0045606)2.50610279
150production of molecular mediator involved in inflammatory response (GO:0002532)2.50563725
151pre-miRNA processing (GO:0031054)2.50024857
152negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49335024
153maternal placenta development (GO:0001893)2.49292200
154ribosome biogenesis (GO:0042254)2.48338730
155pantothenate metabolic process (GO:0015939)2.48225773
156positive regulation of keratinocyte differentiation (GO:0045618)2.47905688
157deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.47790074
158positive regulation of uterine smooth muscle contraction (GO:0070474)2.47121837
159trophectodermal cell differentiation (GO:0001829)2.46295339
160lysine catabolic process (GO:0006554)2.46044673
161lysine metabolic process (GO:0006553)2.46044673
162nuclear pore organization (GO:0006999)2.45405874
163positive regulation of chromosome segregation (GO:0051984)2.44958711
164positive regulation of monocyte chemotaxis (GO:0090026)2.44836817
165regulation of translational termination (GO:0006449)2.43923040
166antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42899206
167fatty acid homeostasis (GO:0055089)2.40867385
168regulation of defense response to virus by virus (GO:0050690)2.40770700
169rRNA transcription (GO:0009303)2.39389277
170GMP metabolic process (GO:0046037)2.37891982
171folic acid-containing compound biosynthetic process (GO:0009396)2.36001016
172mitochondrial DNA metabolic process (GO:0032042)2.35586075
173regulation of helicase activity (GO:0051095)2.35077212
174mitochondrial DNA replication (GO:0006264)2.34678078
175oocyte development (GO:0048599)2.34413473
176sphingomyelin metabolic process (GO:0006684)2.33664604
177deoxyribonucleotide biosynthetic process (GO:0009263)2.33480864
178pentose-phosphate shunt (GO:0006098)2.31916604
179dendritic cell migration (GO:0036336)2.31378716
180IMP biosynthetic process (GO:0006188)2.30584124
181negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.29710189
182negative regulation of ligase activity (GO:0051352)2.29710189
183regulation of cellular extravasation (GO:0002691)2.28678789
184long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.28610474
185oxaloacetate metabolic process (GO:0006107)2.28377585
186endosome organization (GO:0007032)2.28322591
187DNA replication initiation (GO:0006270)2.26882354
188regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.26724599
189negative regulation of type 2 immune response (GO:0002829)2.26377003
190signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.26159217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.47477278
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.99932650
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.92805919
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.68700444
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.54459310
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.01067501
7* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.44306766
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.31738661
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.29784699
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.27747691
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15701398
12* MYB_26560356_Chip-Seq_TH2_Human2.93197598
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.65685579
14RUNX_20019798_ChIP-Seq_JUKART_Human2.63972409
15MAF_26560356_Chip-Seq_TH1_Human2.57205271
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55070639
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51149698
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46686379
19MYB_26560356_Chip-Seq_TH1_Human2.39238813
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.38459844
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38422860
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.36822065
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36342068
24AR_21909140_ChIP-Seq_LNCAP_Human2.33774108
25MYC_22102868_ChIP-Seq_BL_Human2.26349720
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25610309
27UTX_26944678_Chip-Seq_JUKART_Human2.24155905
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23950119
29SPI1_23547873_ChIP-Seq_NB4_Human2.23799559
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.20493099
31E2F7_22180533_ChIP-Seq_HELA_Human2.05234133
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98055410
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.97293861
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97061488
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90753978
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86148616
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84818197
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81791468
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81791468
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81791468
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77649963
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73637299
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73480467
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73013723
45GATA3_27048872_Chip-Seq_THYMUS_Human1.70108363
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69886090
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68367576
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.68018400
49* MAF_26560356_Chip-Seq_TH2_Human1.66379796
50VDR_21846776_ChIP-Seq_THP-1_Human1.65597269
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65058847
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64446336
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61696171
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60888941
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58165435
56VDR_24763502_ChIP-Seq_THP-1_Human1.57553336
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57041877
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56580075
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55286430
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54204678
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54081238
62CHD1_26751641_Chip-Seq_LNCaP_Human1.54057287
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53684460
64RACK7_27058665_Chip-Seq_MCF-7_Human1.52973380
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52755429
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52626188
67KDM5A_27292631_Chip-Seq_BREAST_Human1.51211531
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.49831505
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49526272
70SCL_19346495_ChIP-Seq_HPC-7_Human1.45490877
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44837140
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44619662
73SPI1_23127762_ChIP-Seq_K562_Human1.44342482
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41917631
75GATA6_25053715_ChIP-Seq_YYC3_Human1.41470336
76VDR_23849224_ChIP-Seq_CD4+_Human1.40702561
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39942659
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39899717
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38632246
80* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38175269
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.36825678
82DCP1A_22483619_ChIP-Seq_HELA_Human1.35892678
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35682575
84FOXP3_21729870_ChIP-Seq_TREG_Human1.35076127
85* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32952319
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32579360
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32539705
88PU_27001747_Chip-Seq_BMDM_Mouse1.32029110
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.31240964
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30925404
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29923312
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.29132270
93* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28200690
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26794133
95GATA3_26560356_Chip-Seq_TH2_Human1.25388404
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24760143
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23811171
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22691185
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21480833
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.20976927
101ELF5_23300383_ChIP-Seq_T47D_Human1.20969255
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20165162
103XRN2_22483619_ChIP-Seq_HELA_Human1.19609975
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17604740
105GABP_19822575_ChIP-Seq_HepG2_Human1.16440721
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16435252
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16300612
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15858367
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14859557
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13967519
111KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13709389
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12204553
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11795712
114TCF7_22412390_ChIP-Seq_EML_Mouse1.11590715
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10807597
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10272245
117TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09676707
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09193360
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08841253
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07296616
121GATA3_24758297_ChIP-Seq_MCF-7_Human1.07138279
122EST1_17652178_ChIP-ChIP_JURKAT_Human1.06176295
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05762865
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05700266
125ZNF263_19887448_ChIP-Seq_K562_Human1.04226843
126THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03103262
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02815226
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02060706
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01769789
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.01547007
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00320677
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99028855
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98859155
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98814442
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.98701431
136CIITA_25753668_ChIP-Seq_RAJI_Human0.98669141
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98647996
138PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98024697
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98016828
140* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97343326
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94628443
142EGR1_19032775_ChIP-ChIP_M12_Human0.94023624
143GATA1_22025678_ChIP-Seq_K562_Human0.93490690
144ELK1_19687146_ChIP-ChIP_HELA_Human0.88802723
145KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88325729
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87753902
147ELK3_25401928_ChIP-Seq_HUVEC_Human0.83656329
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82598747
149KDM2B_26808549_Chip-Seq_DND41_Human0.80523208
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78955970
151FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78922052
152FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.78391982
153PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78155385
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74125387
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72767835
156TFEB_21752829_ChIP-Seq_HELA_Human0.71727439
157FOXM1_23109430_ChIP-Seq_U2OS_Human0.71605551
158SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71029396
159ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70828037
160KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.70500478
161SRF_21415370_ChIP-Seq_HL-1_Mouse0.69380527
162PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68871532
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68730674
164RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68401490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.02958380
2MP0010234_abnormal_vibrissa_follicle4.86415621
3MP0005671_abnormal_response_to4.79463434
4MP0003763_abnormal_thymus_physiology3.75552853
5MP0000685_abnormal_immune_system3.53613804
6MP0009785_altered_susceptibility_to3.53493172
7MP0002166_altered_tumor_susceptibility3.41935452
8MP0002254_reproductive_system_inflammat3.28051971
9MP0001790_abnormal_immune_system3.22058780
10MP0005387_immune_system_phenotype3.22058780
11MP0001800_abnormal_humoral_immune3.14742574
12MP0006082_CNS_inflammation3.13809332
13MP0003724_increased_susceptibility_to3.12935073
14MP0005000_abnormal_immune_tolerance3.04082074
15MP0005025_abnormal_response_to2.99163539
16MP0002006_tumorigenesis2.97137360
17MP0002723_abnormal_immune_serum2.86298423
18MP0004264_abnormal_extraembryonic_tissu2.80418354
19MP0002420_abnormal_adaptive_immunity2.79435467
20MP0001819_abnormal_immune_cell2.78751576
21MP0002452_abnormal_antigen_presenting2.77468227
22MP0002796_impaired_skin_barrier2.64422866
23MP0002405_respiratory_system_inflammati2.59710866
24MP0004957_abnormal_blastocyst_morpholog2.53801866
25MP0003436_decreased_susceptibility_to2.48796852
26MP0002398_abnormal_bone_marrow2.45464460
27MP0002148_abnormal_hypersensitivity_rea2.42919542
28MP0009333_abnormal_splenocyte_physiolog2.36454542
29MP0000678_abnormal_parathyroid_gland2.31101556
30MP0000716_abnormal_immune_system2.29442645
31MP0002419_abnormal_innate_immunity2.24921872
32MP0004947_skin_inflammation2.24661465
33MP0001666_abnormal_nutrient_absorption2.10683707
34MP0010155_abnormal_intestine_physiology2.02031257
35MP0002722_abnormal_immune_system1.96755634
36MP0000689_abnormal_spleen_morphology1.94575471
37MP0009672_abnormal_birth_weight1.92801937
38MP0003866_abnormal_defecation1.90874711
39MP0004510_myositis1.87791402
40MP0002429_abnormal_blood_cell1.83215801
41MP0003123_paternal_imprinting1.82314404
42MP0005310_abnormal_salivary_gland1.81542398
43MP0010094_abnormal_chromosome_stability1.81058129
44MP0001845_abnormal_inflammatory_respons1.76974356
45MP0000703_abnormal_thymus_morphology1.75932422
46MP0001853_heart_inflammation1.71771440
47MP0003941_abnormal_skin_development1.67965753
48MP0002933_joint_inflammation1.66871411
49MP0003111_abnormal_nucleus_morphology1.65946524
50MP0005464_abnormal_platelet_physiology1.61814368
51MP0003300_gastrointestinal_ulcer1.61660144
52MP0001730_embryonic_growth_arrest1.56276313
53MP0002396_abnormal_hematopoietic_system1.53633079
54MP0008469_abnormal_protein_level1.48634570
55MP0000858_altered_metastatic_potential1.47201930
56MP0005501_abnormal_skin_physiology1.46317467
57MP0008877_abnormal_DNA_methylation1.45740822
58MP0005379_endocrine/exocrine_gland_phen1.43995841
59MP0005367_renal/urinary_system_phenotyp1.40088476
60MP0000516_abnormal_urinary_system1.40088476
61MP0008260_abnormal_autophagy1.40072312
62MP0001873_stomach_inflammation1.38766479
63MP0002163_abnormal_gland_morphology1.37484370
64MP0001881_abnormal_mammary_gland1.37410090
65MP0001533_abnormal_skeleton_physiology1.33677617
66MP0003448_altered_tumor_morphology1.28466180
67MP0003303_peritoneal_inflammation1.28041216
68MP0000537_abnormal_urethra_morphology1.27465586
69MP0001851_eye_inflammation1.26535895
70MP0005365_abnormal_bile_salt1.26447401
71MP0004185_abnormal_adipocyte_glucose1.26336307
72MP0000627_abnormal_mammary_gland1.21888715
73MP0010678_abnormal_skin_adnexa1.19804846
74MP0003011_delayed_dark_adaptation1.17795234
75MP0002132_abnormal_respiratory_system1.16125283
76MP0003787_abnormal_imprinting1.13871181
77MP0005058_abnormal_lysosome_morphology1.13555463
78MP0002998_abnormal_bone_remodeling1.13481768
79MP0006035_abnormal_mitochondrial_morpho1.09136388
80MP0003221_abnormal_cardiomyocyte_apopto1.08844160
81MP0004233_abnormal_muscle_weight1.07620412
82MP0003566_abnormal_cell_adhesion1.05098248
83MP0003806_abnormal_nucleotide_metabolis1.03164958
84MP0005319_abnormal_enzyme/_coenzyme1.02793326
85MP0000350_abnormal_cell_proliferation1.02787662
86MP0008932_abnormal_embryonic_tissue0.98371262
87MP0009764_decreased_sensitivity_to0.97959357
88MP0002019_abnormal_tumor_incidence0.97916836
89MP0003172_abnormal_lysosome_physiology0.96627760
90MP0000343_altered_response_to0.95044125
91MP0001765_abnormal_ion_homeostasis0.92961090
92MP0002098_abnormal_vibrissa_morphology0.92367854
93MP0000490_abnormal_crypts_of0.91420948
94MP0005075_abnormal_melanosome_morpholog0.91080857
95MP0002080_prenatal_lethality0.90996882
96MP0001346_abnormal_lacrimal_gland0.90811187
97MP0005380_embryogenesis_phenotype0.89228281
98MP0001672_abnormal_embryogenesis/_devel0.89228281
99MP0000377_abnormal_hair_follicle0.89197837
100MP0002009_preneoplasia0.87921422
101MP0002928_abnormal_bile_duct0.87721662
102MP0009763_increased_sensitivity_to0.87105984
103MP0003075_altered_response_to0.86461918
104MP0008057_abnormal_DNA_replication0.85618718
105MP0000465_gastrointestinal_hemorrhage0.85285838
106MP0005636_abnormal_mineral_homeostasis0.84427800
107MP0004808_abnormal_hematopoietic_stem0.84277309
108MP0003984_embryonic_growth_retardation0.83162545
109MP0008007_abnormal_cellular_replicative0.81735686
110MP0003718_maternal_effect0.81716465
111MP0002088_abnormal_embryonic_growth/wei0.81012411
112MP0004782_abnormal_surfactant_physiolog0.80758311
113MP0009703_decreased_birth_body0.80689661
114MP0005332_abnormal_amino_acid0.80041371
115MP0002693_abnormal_pancreas_physiology0.78600036
116MP0010307_abnormal_tumor_latency0.77931380
117MP0005395_other_phenotype0.77704369
118MP0005174_abnormal_tail_pigmentation0.76982407
119MP0003186_abnormal_redox_activity0.76786041
120MP0003656_abnormal_erythrocyte_physiolo0.76485647
121MP0002909_abnormal_adrenal_gland0.76232340
122MP0001727_abnormal_embryo_implantation0.74710252
123MP0002086_abnormal_extraembryonic_tissu0.72899643
124MP0001545_abnormal_hematopoietic_system0.71594670
125MP0005397_hematopoietic_system_phenotyp0.71594670
126MP0003045_fibrosis0.70764387
127MP0005023_abnormal_wound_healing0.70495616
128MP0005076_abnormal_cell_differentiation0.67589470
129MP0003077_abnormal_cell_cycle0.67552807
130MP0003795_abnormal_bone_structure0.66209605
131MP0002136_abnormal_kidney_physiology0.65359972
132MP0010352_gastrointestinal_tract_polyps0.64954651
133MP0003453_abnormal_keratinocyte_physiol0.63617094
134MP0003828_pulmonary_edema0.62314920
135MP0003693_abnormal_embryo_hatching0.62119288
136MP0000477_abnormal_intestine_morphology0.61770124
137MP0002138_abnormal_hepatobiliary_system0.60581637
138MP0009765_abnormal_xenobiotic_induced0.60076601
139MP0001191_abnormal_skin_condition0.56808203
140MP0000383_abnormal_hair_follicle0.55756847
141MP0002877_abnormal_melanocyte_morpholog0.55374806
142MP0004381_abnormal_hair_follicle0.55113543
143MP0003183_abnormal_peptide_metabolism0.55015039
144MP0009643_abnormal_urine_homeostasis0.53987922
145MP0001216_abnormal_epidermal_layer0.53026887
146MP0000609_abnormal_liver_physiology0.52851043
147MP0000604_amyloidosis0.52632293
148MP0003191_abnormal_cellular_cholesterol0.52545646
149MP0000313_abnormal_cell_death0.51067464
150MP0005166_decreased_susceptibility_to0.50944108
151MP0009840_abnormal_foam_cell0.49740922
152MP0008058_abnormal_DNA_repair0.49580253
153MP0000613_abnormal_salivary_gland0.48729421
154MP0005390_skeleton_phenotype0.48072039
155MP0002277_abnormal_respiratory_mucosa0.47805541
156MP0003943_abnormal_hepatobiliary_system0.47077054

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)6.03715086
2Elevated erythrocyte sedimentation rate (HP:0003565)5.74543035
3Recurrent cutaneous fungal infections (HP:0011370)5.49565512
4Chronic mucocutaneous candidiasis (HP:0002728)5.49565512
5Combined immunodeficiency (HP:0005387)5.45309087
6Eczematoid dermatitis (HP:0000976)5.42172584
7Increased IgM level (HP:0003496)5.38038045
8T lymphocytopenia (HP:0005403)5.26282149
9Abnormality of T cell number (HP:0011839)5.25296908
10Hyperphosphatemia (HP:0002905)5.08496548
11Recurrent bronchitis (HP:0002837)5.05666839
12IgG deficiency (HP:0004315)4.89193198
13Symptomatic seizures (HP:0011145)4.71197293
14Stomatitis (HP:0010280)4.71177752
15Recurrent fungal infections (HP:0002841)4.67972844
16Abnormality of T cells (HP:0002843)4.43272930
17Thyroiditis (HP:0100646)4.35254889
18IgM deficiency (HP:0002850)4.22928698
19Recurrent abscess formation (HP:0002722)4.15222992
20Tetany (HP:0001281)4.01888177
21Myositis (HP:0100614)3.97357065
22Chronic diarrhea (HP:0002028)3.95960680
23Chronic otitis media (HP:0000389)3.89050036
24Hypoplasia of the thymus (HP:0000778)3.73293240
25Recurrent skin infections (HP:0001581)3.69097156
26Panhypogammaglobulinemia (HP:0003139)3.64151856
27Abnormality of T cell physiology (HP:0011840)3.62725664
28Agammaglobulinemia (HP:0004432)3.61132634
29Recurrent viral infections (HP:0004429)3.58276061
30Autoimmune hemolytic anemia (HP:0001890)3.57376366
31Birth length less than 3rd percentile (HP:0003561)3.53601029
32Optic neuritis (HP:0100653)3.53561845
33Retrobulbar optic neuritis (HP:0100654)3.53561845
34Neoplasm of the adrenal cortex (HP:0100641)3.43603279
35Bronchitis (HP:0012387)3.42955884
36IgA deficiency (HP:0002720)3.29538080
37Orchitis (HP:0100796)3.28983082
38Abnormality of eosinophils (HP:0001879)3.26199095
39Lymphopenia (HP:0001888)3.24974569
40Hypoglycemic seizures (HP:0002173)3.23426750
41Testicular atrophy (HP:0000029)3.17552832
42Hypoglycemic coma (HP:0001325)3.16626641
43Abnormality of cells of the lymphoid lineage (HP:0012140)3.15799774
44Vasculitis (HP:0002633)3.15169631
45Hypergammaglobulinemia (HP:0010702)3.13544081
46Nasal polyposis (HP:0100582)3.13212366
47Leukocytosis (HP:0001974)3.09159819
48Meningitis (HP:0001287)3.08529213
49Recurrent bacterial skin infections (HP:0005406)3.08256853
50Hemoptysis (HP:0002105)3.02794913
51Hypoparathyroidism (HP:0000829)3.02080239
52Cheilitis (HP:0100825)3.01068983
53Neoplasm of the adrenal gland (HP:0100631)2.99598268
54Pustule (HP:0200039)2.99142032
55Gingivitis (HP:0000230)2.97249204
56Neonatal hypoglycemia (HP:0001998)2.93714790
57Obstructive lung disease (HP:0006536)2.92546521
58Chronic obstructive pulmonary disease (HP:0006510)2.92546521
59Multiple enchondromatosis (HP:0005701)2.90700012
60Spastic diplegia (HP:0001264)2.88296927
61Aplastic anemia (HP:0001915)2.86612135
62Vacuolated lymphocytes (HP:0001922)2.79004183
63Recurrent sinusitis (HP:0011108)2.75147308
64B lymphocytopenia (HP:0010976)2.73781634
65Abnormality of B cell number (HP:0010975)2.73781634
66Septate vagina (HP:0001153)2.72947915
67Encephalitis (HP:0002383)2.71947468
68Gastrointestinal infarctions (HP:0005244)2.68585723
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.68426042
70Hypokinesia (HP:0002375)2.64579473
71Recurrent gram-negative bacterial infections (HP:0005420)2.64172592
72Mediastinal lymphadenopathy (HP:0100721)2.64047603
73Chronic bronchitis (HP:0004469)2.63987536
74Autoimmune thrombocytopenia (HP:0001973)2.63436092
75Villous atrophy (HP:0011473)2.62757612
76Abnormality of small intestinal villus morphology (HP:0011472)2.62757612
77Abnormality of macrophages (HP:0004311)2.61725585
78Abnormality of the fingertips (HP:0001211)2.59794256
79Abnormality of the nasal mucosa (HP:0000433)2.59390561
80Right ventricular cardiomyopathy (HP:0011663)2.56995731
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.53394448
82Pili torti (HP:0003777)2.49079333
83Lymphoma (HP:0002665)2.48708567
84Keratoconjunctivitis sicca (HP:0001097)2.39418769
85Hypomagnesemia (HP:0002917)2.35742375
86Increased cerebral lipofuscin (HP:0011813)2.35527512
87Basal ganglia calcification (HP:0002135)2.35210459
88Inflammation of the large intestine (HP:0002037)2.35013514
89Sparse lateral eyebrow (HP:0005338)2.31722018
90Progressive hearing impairment (HP:0001730)2.30101865
91Eosinophilia (HP:0001880)2.28973513
92Pulmonary infiltrates (HP:0002113)2.28910600
93Joint swelling (HP:0001386)2.27109325
94Megaloblastic anemia (HP:0001889)2.26060476
95Microretrognathia (HP:0000308)2.25544055
96Hyperinsulinemic hypoglycemia (HP:0000825)2.24721445
97Gastrointestinal inflammation (HP:0004386)2.24543779
98Chronic sinusitis (HP:0011109)2.24012880
99Gastrointestinal stroma tumor (HP:0100723)2.23218711
100Reduced subcutaneous adipose tissue (HP:0003758)2.22961965
101Abnormality of the prostate (HP:0008775)2.19449977
102Thrombocytosis (HP:0001894)2.17958327
103Keratoconjunctivitis (HP:0001096)2.17865164
104Ketoacidosis (HP:0001993)2.16752452
105Curly hair (HP:0002212)2.16405310
106Skin rash (HP:0000988)2.16404578
107Premature ovarian failure (HP:0008209)2.14792795
108Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13677384
109Progressive sensorineural hearing impairment (HP:0000408)2.13347837
110J-shaped sella turcica (HP:0002680)2.12253082
111Recurrent pneumonia (HP:0006532)2.12038084
112Petechiae (HP:0000967)2.11162167
113Granulocytopenia (HP:0001913)2.08634197
114Abnormality of magnesium homeostasis (HP:0004921)2.05025892
115Hyponatremia (HP:0002902)2.04298216
116Sepsis (HP:0100806)2.04120814
117Malnutrition (HP:0004395)2.02993895
118Periodontitis (HP:0000704)2.02385944
119Poikiloderma (HP:0001029)2.01864329
120Polyneuropathy (HP:0001271)2.01763947
121Breast carcinoma (HP:0003002)1.99465360
122Anorexia (HP:0002039)1.98767458
123Abnormality of oral frenula (HP:0000190)1.96894700
124Amaurosis fugax (HP:0100576)1.95680937
125Colitis (HP:0002583)1.95363828
126Recurrent otitis media (HP:0000403)1.94762742
127Asymmetry of the thorax (HP:0001555)1.94580395
128Arterial thrombosis (HP:0004420)1.93738466
129Abnormality of the pancreatic islet cells (HP:0006476)1.93329952
130Abnormality of endocrine pancreas physiology (HP:0012093)1.93329952
131Prolonged partial thromboplastin time (HP:0003645)1.91502624
132Aplasia/Hypoplasia of the thymus (HP:0010515)1.90504289
133Skin ulcer (HP:0200042)1.90330916
134Gonadotropin excess (HP:0000837)1.89587493
135Abnormality of methionine metabolism (HP:0010901)1.89527122
136Trismus (HP:0000211)1.89319435
137Abnormality of the endocardium (HP:0004306)1.89119851
138Dysostosis multiplex (HP:0000943)1.88386328
139Cellulitis (HP:0100658)1.88183591
140Interstitial pulmonary disease (HP:0006530)1.87941210
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.87745710
142Emphysema (HP:0002097)1.87107144
143Long clavicles (HP:0000890)1.86780129
144Keratitis (HP:0000491)1.86075982
145Hypoproteinemia (HP:0003075)1.84399114
146Gangrene (HP:0100758)1.83922761
147Hyperactive renin-angiotensin system (HP:0000841)1.83702784
148Abnormality of saccadic eye movements (HP:0000570)1.83657179
149Recurrent lower respiratory tract infections (HP:0002783)1.83293241
150Slow saccadic eye movements (HP:0000514)1.83201473
151Homocystinuria (HP:0002156)1.82140104
152Abnormality of homocysteine metabolism (HP:0010919)1.82140104
153Spontaneous hematomas (HP:0007420)1.80056252
154Prominent metopic ridge (HP:0005487)1.77881266
155Ketosis (HP:0001946)1.76072825
156Clitoromegaly (HP:0000057)1.73971564
157Pancytopenia (HP:0001876)1.73107480
158Micronodular cirrhosis (HP:0001413)1.72840491
159Abnormal biliary tract physiology (HP:0012439)1.71080588
160Bile duct proliferation (HP:0001408)1.71080588
161Ependymoma (HP:0002888)1.70404884
162Muscle fibrillation (HP:0010546)1.69127566
163Reduced antithrombin III activity (HP:0001976)1.67930884
164Cellular immunodeficiency (HP:0005374)1.66492254
165Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66340897
166Persistence of primary teeth (HP:0006335)1.66155019
167Limb hypertonia (HP:0002509)1.64478741
168Nephroblastoma (Wilms tumor) (HP:0002667)1.62780038
169Abnormality of the salivary glands (HP:0010286)1.62115266
170Resting tremor (HP:0002322)1.60983431
171Unilateral renal agenesis (HP:0000122)1.60138823
172Oligomenorrhea (HP:0000876)1.60033967
173Abnormal hair whorl (HP:0010721)1.59951875
174Abnormal protein glycosylation (HP:0012346)1.59937464
175Abnormal glycosylation (HP:0012345)1.59937464
176Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59937464
177Abnormal protein N-linked glycosylation (HP:0012347)1.59937464
178Deep philtrum (HP:0002002)1.59174149
179Prostate neoplasm (HP:0100787)1.57270215
180Abnormality of the intrinsic pathway (HP:0010989)1.55591479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.06289219
2MAP4K15.74658770
3SMG14.55777993
4STK243.87185977
5FGFR43.77706002
6TSSK63.56795318
7IKBKE3.43548352
8ZAP703.24980328
9KIT3.14357857
10TYK23.05334043
11JAK32.91690388
12KDR2.76109926
13TESK22.71549018
14EPHA22.64393537
15TAF12.44764326
16VRK22.43829968
17TBK12.39014044
18TRIB32.22753516
19BLK2.19745466
20JAK12.03691580
21MAP3K122.03120996
22FGFR32.01748091
23MST41.94455637
24ITK1.93824077
25CDK121.92340732
26TTK1.85484900
27TAOK11.76360021
28STK101.72155241
29CAMK1D1.70984437
30SIK11.68498085
31TEC1.66109566
32SYK1.61700235
33LCK1.60225296
34ALK1.59383377
35BTK1.58740976
36TESK11.57565751
37EEF2K1.57383124
38IRAK41.55718096
39MAP3K141.55485322
40MAP3K31.40804118
41NME21.26370434
42CSF1R1.25746399
43BRSK21.23373738
44LYN1.23236527
45CSK1.21983787
46IKBKB1.21587138
47PLK31.19811697
48MST1R1.17123634
49CAMK1G1.16918606
50GRK61.12677555
51NEK61.07553393
52LRRK21.06630510
53SCYL21.05694713
54TNK21.01930201
55HCK0.97932580
56CDC70.96852898
57CDK70.96747784
58SRPK10.96378710
59PASK0.96290622
60PRKCH0.95674030
61NLK0.94339512
62TAOK30.93454640
63PRPF4B0.93303515
64MAPK110.91883398
65TLK10.90828269
66CDK90.90195764
67MAP3K20.87898143
68PRKCQ0.83448267
69ERN10.82522346
70FER0.82327698
71FGFR20.82324695
72MAP3K80.78160642
73YES10.77805756
74JAK20.76005541
75BUB10.74987547
76PRKD30.69995911
77MAP3K130.66215535
78PTK60.65528133
79EIF2AK30.65025439
80IRAK10.63170338
81PIM20.61354713
82CHUK0.60588402
83LIMK10.59906986
84LMTK20.59756855
85MYLK0.59519137
86TGFBR20.59206265
87NUAK10.58549068
88NEK10.57153850
89IRAK30.56513457
90MAP2K20.56368746
91ATR0.55552735
92EIF2AK10.55037714
93RIPK40.54401494
94CLK10.52945338
95TRIM280.52861193
96HIPK20.52155815
97STK40.52124531
98PLK10.51791824
99SIK30.51112438
100RPS6KA50.50656350
101MAP2K30.48860115
102AURKA0.48754501
103MARK30.47767586
104CHEK20.46641837
105FLT30.46334285
106CHEK10.46019548
107PRKCD0.45067528
108PIM10.43599638
109FES0.43036006
110BRSK10.42786776
111ACVR1B0.42223810
112RPS6KA40.41606048
113MARK20.40592970
114NME10.40083877
115MAP3K100.39176515
116STK390.38595730
117FYN0.38292083
118VRK10.37628317
119ADRBK20.36176031
120MTOR0.34967407
121STK38L0.33542145
122PBK0.32791670
123PLK40.32580155
124SIK20.28853176
125MAPKAPK20.27822650
126MAPK150.27391418
127ABL10.27253220
128PDK10.26342058
129INSR0.25239557
130IGF1R0.24926242
131ZAK0.23570977
132PIK3CG0.20549740
133ILK0.20439915
134EPHA30.20215749
135TGFBR10.20134822
136PAK40.19839356
137PRKG20.18926675
138DAPK30.18326896
139RPS6KB20.18279471
140EPHB10.16885386
141BMPR1B0.16699173
142MAPK30.16434776
143STK160.15816602
144MAPKAPK30.15042000
145EIF2AK20.14527943
146PRKCI0.14227566
147DAPK10.14054346
148NEK90.13940920
149AURKB0.13632717

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.78147767
2Vitamin B6 metabolism_Homo sapiens_hsa007503.86148890
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.05428331
4Allograft rejection_Homo sapiens_hsa053303.03455434
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.89226057
6Antigen processing and presentation_Homo sapiens_hsa046122.88827903
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.88284648
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.80956290
9Graft-versus-host disease_Homo sapiens_hsa053322.79164699
10Measles_Homo sapiens_hsa051622.57760020
11T cell receptor signaling pathway_Homo sapiens_hsa046602.47207378
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.45508007
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22356646
14Leishmaniasis_Homo sapiens_hsa051402.22075364
15Asthma_Homo sapiens_hsa053102.20126645
16Caffeine metabolism_Homo sapiens_hsa002322.20067581
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15507544
18Autoimmune thyroid disease_Homo sapiens_hsa053202.09921247
19Hematopoietic cell lineage_Homo sapiens_hsa046402.09879471
20Viral myocarditis_Homo sapiens_hsa054161.98885428
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97639095
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83159187
23Propanoate metabolism_Homo sapiens_hsa006401.75947050
24Other glycan degradation_Homo sapiens_hsa005111.73887045
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72850476
26Herpes simplex infection_Homo sapiens_hsa051681.71676920
27Osteoclast differentiation_Homo sapiens_hsa043801.67766707
28B cell receptor signaling pathway_Homo sapiens_hsa046621.67643720
29Fatty acid biosynthesis_Homo sapiens_hsa000611.65186226
30Biosynthesis of amino acids_Homo sapiens_hsa012301.61516566
31Thyroid cancer_Homo sapiens_hsa052161.60456090
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59868145
33Galactose metabolism_Homo sapiens_hsa000521.58538117
34Arginine biosynthesis_Homo sapiens_hsa002201.57830024
35Carbon metabolism_Homo sapiens_hsa012001.53998523
36Steroid biosynthesis_Homo sapiens_hsa001001.53459259
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49647744
38Pyruvate metabolism_Homo sapiens_hsa006201.46048539
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45287110
40Vitamin digestion and absorption_Homo sapiens_hsa049771.43937431
41Fatty acid metabolism_Homo sapiens_hsa012121.37304404
42Endometrial cancer_Homo sapiens_hsa052131.35870324
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.35358813
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32496944
45Protein export_Homo sapiens_hsa030601.31617145
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26236735
47RNA transport_Homo sapiens_hsa030131.24762488
48Toxoplasmosis_Homo sapiens_hsa051451.23630975
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.23458137
50Influenza A_Homo sapiens_hsa051641.23152806
51Prostate cancer_Homo sapiens_hsa052151.18768391
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.18467429
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17131118
54Type I diabetes mellitus_Homo sapiens_hsa049401.16137805
55Shigellosis_Homo sapiens_hsa051311.13750364
56One carbon pool by folate_Homo sapiens_hsa006701.13540560
57Proteasome_Homo sapiens_hsa030501.12709925
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12444114
59Lysosome_Homo sapiens_hsa041421.12396792
60Legionellosis_Homo sapiens_hsa051341.09860130
61Staphylococcus aureus infection_Homo sapiens_hsa051501.09752100
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08929697
63Malaria_Homo sapiens_hsa051441.08302080
64Ribosome_Homo sapiens_hsa030101.07835483
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.07202107
66Chemokine signaling pathway_Homo sapiens_hsa040621.07198521
67Tuberculosis_Homo sapiens_hsa051521.07004066
68Selenocompound metabolism_Homo sapiens_hsa004501.06974795
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06912835
70Fatty acid elongation_Homo sapiens_hsa000621.05113900
71Cell cycle_Homo sapiens_hsa041101.04857401
72Pertussis_Homo sapiens_hsa051331.03725415
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02394118
74Apoptosis_Homo sapiens_hsa042101.02276710
75RNA polymerase_Homo sapiens_hsa030201.01074357
76NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00860099
77Hepatitis B_Homo sapiens_hsa051610.95795458
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.95135863
79Glutathione metabolism_Homo sapiens_hsa004800.90299531
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90036393
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86664259
82Adherens junction_Homo sapiens_hsa045200.86172790
83Salmonella infection_Homo sapiens_hsa051320.84869293
84Vibrio cholerae infection_Homo sapiens_hsa051100.84721948
85DNA replication_Homo sapiens_hsa030300.83497279
86Hepatitis C_Homo sapiens_hsa051600.82767820
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82436774
88mRNA surveillance pathway_Homo sapiens_hsa030150.81425985
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80385967
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79994109
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78438097
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76600446
93Fat digestion and absorption_Homo sapiens_hsa049750.75407149
94Base excision repair_Homo sapiens_hsa034100.75157682
95Inositol phosphate metabolism_Homo sapiens_hsa005620.74904300
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73640763
97TNF signaling pathway_Homo sapiens_hsa046680.73525293
98Insulin resistance_Homo sapiens_hsa049310.72177714
99Fatty acid degradation_Homo sapiens_hsa000710.71694507
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71162923
101Non-small cell lung cancer_Homo sapiens_hsa052230.70678657
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.70374982
103Insulin signaling pathway_Homo sapiens_hsa049100.70247746
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.69593630
105Non-homologous end-joining_Homo sapiens_hsa034500.68648272
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67757410
107Nucleotide excision repair_Homo sapiens_hsa034200.67351212
108beta-Alanine metabolism_Homo sapiens_hsa004100.66036964
109Glucagon signaling pathway_Homo sapiens_hsa049220.65964202
110HTLV-I infection_Homo sapiens_hsa051660.65865796
111Mismatch repair_Homo sapiens_hsa034300.65852223
112Pancreatic cancer_Homo sapiens_hsa052120.65121803
113Rheumatoid arthritis_Homo sapiens_hsa053230.65032972
114p53 signaling pathway_Homo sapiens_hsa041150.63199689
115Arginine and proline metabolism_Homo sapiens_hsa003300.62214418
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60136867
117Sphingolipid metabolism_Homo sapiens_hsa006000.58226533
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57662197
119Lysine degradation_Homo sapiens_hsa003100.57593007
120Platelet activation_Homo sapiens_hsa046110.56528031
121Viral carcinogenesis_Homo sapiens_hsa052030.55557199
122AMPK signaling pathway_Homo sapiens_hsa041520.55183607
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53391214
124Prolactin signaling pathway_Homo sapiens_hsa049170.52919779
125Chronic myeloid leukemia_Homo sapiens_hsa052200.52299484
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51139364
127Epstein-Barr virus infection_Homo sapiens_hsa051690.50561223
128Fructose and mannose metabolism_Homo sapiens_hsa000510.50457949
129Homologous recombination_Homo sapiens_hsa034400.50267826
130Starch and sucrose metabolism_Homo sapiens_hsa005000.49964467
131Spliceosome_Homo sapiens_hsa030400.48452168
132FoxO signaling pathway_Homo sapiens_hsa040680.47058618
133Pentose phosphate pathway_Homo sapiens_hsa000300.46603193
134RNA degradation_Homo sapiens_hsa030180.45237811
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.44489839
136Peroxisome_Homo sapiens_hsa041460.42462881
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42438731
138Pyrimidine metabolism_Homo sapiens_hsa002400.41609388
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40600944
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40088671
141Acute myeloid leukemia_Homo sapiens_hsa052210.36737663
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36176789
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34511006
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34383453
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31580597
146VEGF signaling pathway_Homo sapiens_hsa043700.30995027
147Phagosome_Homo sapiens_hsa041450.30916799
148Sulfur metabolism_Homo sapiens_hsa009200.28201805
149Endocytosis_Homo sapiens_hsa041440.25748877
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25322257
151Systemic lupus erythematosus_Homo sapiens_hsa053220.25201039
152Basal transcription factors_Homo sapiens_hsa030220.23861517
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23358336
154Renin-angiotensin system_Homo sapiens_hsa046140.22903067
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.20745927
156African trypanosomiasis_Homo sapiens_hsa051430.20422457
157ABC transporters_Homo sapiens_hsa020100.20397945
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18384729
159Notch signaling pathway_Homo sapiens_hsa043300.16937723
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15360651
161Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14605676
162Colorectal cancer_Homo sapiens_hsa052100.13876602

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