RAB1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)7.25245277
2cytidine metabolic process (GO:0046087)7.25245277
3cytidine catabolic process (GO:0006216)7.25245277
4pyrimidine ribonucleoside catabolic process (GO:0046133)6.47530000
5DNA deamination (GO:0045006)6.43200883
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.26889938
7negative regulation of T cell apoptotic process (GO:0070233)5.90809169
8regulation of activation of Janus kinase activity (GO:0010533)5.36704788
9Arp2/3 complex-mediated actin nucleation (GO:0034314)5.14979221
10negative regulation by host of viral transcription (GO:0043922)5.09059830
11regulation of T cell chemotaxis (GO:0010819)4.94865946
12positive regulation of T cell chemotaxis (GO:0010820)4.94865946
13positive regulation of interleukin-8 secretion (GO:2000484)4.70934666
14T cell migration (GO:0072678)4.70721425
15positive regulation of natural killer cell mediated immunity (GO:0002717)4.69920680
16negative regulation of lymphocyte apoptotic process (GO:0070229)4.62075570
17actin nucleation (GO:0045010)4.58471603
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.58009415
19positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.48506786
20regulation of T cell mediated cytotoxicity (GO:0001914)4.47831558
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.47257577
22regulation of leukocyte mediated cytotoxicity (GO:0001910)4.34028047
23eosinophil chemotaxis (GO:0048245)4.30639079
24positive regulation of monocyte chemotaxis (GO:0090026)4.29985581
25positive regulation of T cell mediated cytotoxicity (GO:0001916)4.22034714
26negative regulation of stress fiber assembly (GO:0051497)4.19575532
27glycine transport (GO:0015816)4.18247100
28regulation of regulatory T cell differentiation (GO:0045589)4.16711197
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.08192871
30regulation of lymphocyte chemotaxis (GO:1901623)4.05019459
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02545398
32negative regulation of cell killing (GO:0031342)4.02545398
33positive regulation of defense response to virus by host (GO:0002230)4.00067830
34regulation of natural killer cell mediated immunity (GO:0002715)3.99311752
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.99311752
36cellular response to interleukin-15 (GO:0071350)3.96869306
37macrophage chemotaxis (GO:0048246)3.94932762
38positive thymic T cell selection (GO:0045059)3.92888069
39positive regulation of cell killing (GO:0031343)3.92497816
40regulation of T cell apoptotic process (GO:0070232)3.92114403
41regulation of chronic inflammatory response (GO:0002676)3.89085583
42eosinophil migration (GO:0072677)3.87203665
43regulation of cell killing (GO:0031341)3.81089118
44positive regulation of calcium-mediated signaling (GO:0050850)3.78625449
45negative T cell selection (GO:0043383)3.72796584
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.69327085
47positive regulation of translational initiation (GO:0045948)3.68502777
48regulation of interleukin-8 secretion (GO:2000482)3.62846931
49negative regulation of actin filament bundle assembly (GO:0032232)3.62659885
50monocyte chemotaxis (GO:0002548)3.60888328
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57556107
52lymphocyte chemotaxis (GO:0048247)3.56051121
53regulation of T cell migration (GO:2000404)3.54104066
54positive regulation of gamma-delta T cell activation (GO:0046645)3.51521035
55positive regulation of lymphocyte migration (GO:2000403)3.50679502
56negative thymic T cell selection (GO:0045060)3.50555737
57chemokine-mediated signaling pathway (GO:0070098)3.42538635
58negative regulation of leukocyte apoptotic process (GO:2000107)3.41231444
59regulation of T cell receptor signaling pathway (GO:0050856)3.41119740
60regulation of interleukin-2 biosynthetic process (GO:0045076)3.40988375
61negative regulation of viral genome replication (GO:0045071)3.33779179
62positive regulation of T cell migration (GO:2000406)3.33446488
63thymic T cell selection (GO:0045061)3.32827309
64response to gravity (GO:0009629)3.32076519
65sequestering of actin monomers (GO:0042989)3.30780522
66positive T cell selection (GO:0043368)3.29927853
67cellular defense response (GO:0006968)3.26297032
68positive regulation of interleukin-4 production (GO:0032753)3.23993984
69negative regulation of viral transcription (GO:0032897)3.18058556
70dendritic cell chemotaxis (GO:0002407)3.16448003
71regulation of macrophage chemotaxis (GO:0010758)3.14073733
72regulation of lymphocyte migration (GO:2000401)3.14005842
73positive regulation of T cell mediated immunity (GO:0002711)3.13767987
74response to interleukin-15 (GO:0070672)3.12152425
75regulation of B cell receptor signaling pathway (GO:0050855)3.11895512
76T cell costimulation (GO:0031295)3.08652770
77metallo-sulfur cluster assembly (GO:0031163)3.06313518
78iron-sulfur cluster assembly (GO:0016226)3.06313518
79T cell receptor signaling pathway (GO:0050852)3.05590835
80regulation of T cell tolerance induction (GO:0002664)3.05469479
81lymphocyte costimulation (GO:0031294)3.04750153
82negative regulation of telomere maintenance (GO:0032205)3.04272239
83regulation of T cell mediated immunity (GO:0002709)3.02395892
84negative regulation of B cell apoptotic process (GO:0002903)3.02110919
85lymphocyte migration (GO:0072676)3.02107506
86regulation of lymphocyte apoptotic process (GO:0070228)3.01959187
87regulation of gamma-delta T cell differentiation (GO:0045586)3.01491327
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.99713088
89neutrophil activation (GO:0042119)2.96977691
90mast cell activation involved in immune response (GO:0002279)2.95131737
91mast cell degranulation (GO:0043303)2.95131737
92cellular response to exogenous dsRNA (GO:0071360)2.94808099
93regulation of chemokine-mediated signaling pathway (GO:0070099)2.93572227
94modulation by host of symbiont transcription (GO:0052472)2.92278254
95modulation by host of viral transcription (GO:0043921)2.92278254
96cytolysis (GO:0019835)2.90919969
97positive regulation of tolerance induction (GO:0002645)2.90108225
98interferon-gamma production (GO:0032609)2.88108470
99regulation of calcium-mediated signaling (GO:0050848)2.86561990
100regulation of mononuclear cell migration (GO:0071675)2.86476459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.71135568
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.28767636
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.71246436
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.43887982
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.04541492
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.78131458
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32871322
8RUNX_20019798_ChIP-Seq_JUKART_Human3.05327476
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03225110
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.96437509
11MYB_26560356_Chip-Seq_TH2_Human2.82989634
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74748795
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54119835
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40022662
15GATA3_27048872_Chip-Seq_THYMUS_Human2.37885738
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.32258496
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.23766105
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.13660099
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12134386
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.02570988
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00108239
22UTX_26944678_Chip-Seq_JUKART_Human1.92251886
23MYB_26560356_Chip-Seq_TH1_Human1.85798227
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81771500
25GATA3_26560356_Chip-Seq_TH2_Human1.79480634
26VDR_23849224_ChIP-Seq_CD4+_Human1.78712189
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78595218
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78162642
29BCL6_27268052_Chip-Seq_Bcells_Human1.77149844
30CIITA_25753668_ChIP-Seq_RAJI_Human1.75911372
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73130716
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69426389
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65140992
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62099057
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60263657
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59881909
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59844327
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57330399
39MAF_26560356_Chip-Seq_TH1_Human1.52158110
40P300_27268052_Chip-Seq_Bcells_Human1.51015614
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50593727
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42816863
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42786489
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39555915
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38354582
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37934450
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37855332
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35825785
49MYC_18940864_ChIP-ChIP_HL60_Human1.34945096
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.33490603
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32361152
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25530141
53TP53_22573176_ChIP-Seq_HFKS_Human1.24507791
54SPI1_23547873_ChIP-Seq_NB4_Human1.24497459
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23137697
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20165379
57TAF2_19829295_ChIP-Seq_ESCs_Human1.18166335
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.17017459
59CTCF_20526341_ChIP-Seq_ESCs_Human1.16586185
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16491291
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15007265
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14014150
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.10145151
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10018494
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.08759226
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07970860
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07368844
68MAF_26560356_Chip-Seq_TH2_Human1.07011275
69GATA3_26560356_Chip-Seq_TH1_Human1.06905128
70FOXP3_21729870_ChIP-Seq_TREG_Human1.05338618
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.05299070
72VDR_22108803_ChIP-Seq_LS180_Human1.05271943
73NANOG_20526341_ChIP-Seq_ESCs_Human1.03516300
74BCOR_27268052_Chip-Seq_Bcells_Human1.03266464
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.01841093
76SCL_19346495_ChIP-Seq_HPC-7_Human0.99575181
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99348981
78AR_20517297_ChIP-Seq_VCAP_Human0.98892161
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96577012
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.95942779
81CTCF_26484167_Chip-Seq_Bcells_Mouse0.94541478
82RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93367553
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92760883
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92730973
85ETS1_20019798_ChIP-Seq_JURKAT_Human0.92517511
86FLI1_21867929_ChIP-Seq_CD8_Mouse0.90457889
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.89561858
88ERG_20517297_ChIP-Seq_VCAP_Human0.88046963
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86263563
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85784127
91SA1_27219007_Chip-Seq_Bcells_Human0.85168552
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84803565
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83296606
94RXR_22108803_ChIP-Seq_LS180_Human0.83282172
95E2F1_20622854_ChIP-Seq_HELA_Human0.82611764
96RAC3_21632823_ChIP-Seq_H3396_Human0.82224121
97ERA_21632823_ChIP-Seq_H3396_Human0.81555181
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.81348145
99EST1_17652178_ChIP-ChIP_JURKAT_Human0.81274496
100CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78442912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.40490022
2MP0004147_increased_porphyrin_level3.33913741
3MP0009785_altered_susceptibility_to3.05422304
4MP0001835_abnormal_antigen_presentation3.02492767
5MP0005083_abnormal_biliary_tract2.99580566
6MP0005000_abnormal_immune_tolerance2.86000770
7MP0003763_abnormal_thymus_physiology2.83202839
8MP0002148_abnormal_hypersensitivity_rea2.80002633
9MP0002723_abnormal_immune_serum2.53124826
10MP0002420_abnormal_adaptive_immunity2.50012767
11MP0001819_abnormal_immune_cell2.42982572
12MP0001800_abnormal_humoral_immune2.42176767
13MP0005025_abnormal_response_to2.36060458
14MP0009333_abnormal_splenocyte_physiolog2.32024762
15MP0005387_immune_system_phenotype2.31705905
16MP0001790_abnormal_immune_system2.31705905
17MP0002452_abnormal_antigen_presenting2.09676419
18MP0002138_abnormal_hepatobiliary_system2.09632800
19MP0000465_gastrointestinal_hemorrhage2.02552792
20MP0003436_decreased_susceptibility_to1.99038596
21MP0006082_CNS_inflammation1.95643795
22MP0002398_abnormal_bone_marrow1.92024424
23MP0003866_abnormal_defecation1.89160184
24MP0001905_abnormal_dopamine_level1.83903888
25MP0003045_fibrosis1.83836379
26MP0000685_abnormal_immune_system1.81586975
27MP0003950_abnormal_plasma_membrane1.79545074
28MP0000716_abnormal_immune_system1.78780826
29MP0005645_abnormal_hypothalamus_physiol1.70066633
30MP0000689_abnormal_spleen_morphology1.68401248
31MP0004134_abnormal_chest_morphology1.65239641
32MP0002166_altered_tumor_susceptibility1.61199438
33MP0002722_abnormal_immune_system1.60696077
34MP0002876_abnormal_thyroid_physiology1.56942073
35MP0000703_abnormal_thymus_morphology1.50436571
36MP0003011_delayed_dark_adaptation1.47554952
37MP0002419_abnormal_innate_immunity1.42697391
38MP0002653_abnormal_ependyma_morphology1.39850431
39MP0002429_abnormal_blood_cell1.39570594
40MP0004142_abnormal_muscle_tone1.38891644
41MP0001968_abnormal_touch/_nociception1.35741922
42MP0002102_abnormal_ear_morphology1.33909994
43MP0002006_tumorigenesis1.33907388
44MP0005646_abnormal_pituitary_gland1.33049743
45MP0004145_abnormal_muscle_electrophysio1.32118084
46MP0005075_abnormal_melanosome_morpholog1.23513918
47MP0001542_abnormal_bone_strength1.22914875
48MP0001853_heart_inflammation1.22866550
49MP0002405_respiratory_system_inflammati1.22073665
50MP0003880_abnormal_central_pattern1.21700725
51MP0003878_abnormal_ear_physiology1.20585002
52MP0005377_hearing/vestibular/ear_phenot1.20585002
53MP0005464_abnormal_platelet_physiology1.14823476
54MP0001845_abnormal_inflammatory_respons1.13869227
55MP0003448_altered_tumor_morphology1.12420283
56MP0008469_abnormal_protein_level1.11573886
57MP0010155_abnormal_intestine_physiology1.10564164
58MP0009763_increased_sensitivity_to1.09415179
59MP0001919_abnormal_reproductive_system1.09414296
60MP0001984_abnormal_olfaction1.08844270
61MP0003693_abnormal_embryo_hatching1.05989109
62MP0008872_abnormal_physiological_respon1.05100388
63MP0003137_abnormal_impulse_conducting1.03610537
64MP0000372_irregular_coat_pigmentation1.02255645
65MP0002019_abnormal_tumor_incidence1.01775929
66MP0008875_abnormal_xenobiotic_pharmacok0.98297599
67MP0001661_extended_life_span0.98025211
68MP0001188_hyperpigmentation0.96780201
69MP0001533_abnormal_skeleton_physiology0.96580572
70MP0004947_skin_inflammation0.90789549
71MP0002736_abnormal_nociception_after0.90480298
72MP0001764_abnormal_homeostasis0.90194269
73MP0005166_decreased_susceptibility_to0.89611385
74MP0005389_reproductive_system_phenotype0.88599218
75MP0004043_abnormal_pH_regulation0.86959296
76MP0005551_abnormal_eye_electrophysiolog0.85045623
77MP0003724_increased_susceptibility_to0.83251701
78MP0009745_abnormal_behavioral_response0.82344485
79MP0003252_abnormal_bile_duct0.81830573
80MP0005084_abnormal_gallbladder_morpholo0.81456354
81MP0010386_abnormal_urinary_bladder0.80347621
82MP0003786_premature_aging0.80245648
83MP0009764_decreased_sensitivity_to0.79509156
84MP0006054_spinal_hemorrhage0.78953052
85MP0005165_increased_susceptibility_to0.78702106
86MP0006072_abnormal_retinal_apoptosis0.76622582
87MP0001765_abnormal_ion_homeostasis0.76421445
88MP0005253_abnormal_eye_physiology0.74860950
89MP0008877_abnormal_DNA_methylation0.71856613
90MP0003191_abnormal_cellular_cholesterol0.70636340
91MP0003075_altered_response_to0.70088783
92MP0004185_abnormal_adipocyte_glucose0.69232628
93MP0005584_abnormal_enzyme/coenzyme_acti0.68074520
94MP0002933_joint_inflammation0.67783069
95MP0005503_abnormal_tendon_morphology0.67117737
96MP0002733_abnormal_thermal_nociception0.67054685
97MP0006036_abnormal_mitochondrial_physio0.64067641
98MP0009765_abnormal_xenobiotic_induced0.63590609
99MP0003195_calcinosis0.63562358
100MP0001348_abnormal_lacrimal_gland0.63293068

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.88294064
2IgG deficiency (HP:0004315)5.71311332
3Agammaglobulinemia (HP:0004432)5.36531347
4Abnormality of T cell number (HP:0011839)5.10582239
5Aplastic anemia (HP:0001915)5.03402548
6Severe combined immunodeficiency (HP:0004430)4.49654010
7Hypoproteinemia (HP:0003075)3.89710306
8Thyroiditis (HP:0100646)3.86500671
9Recurrent bronchitis (HP:0002837)3.82392072
10Abnormality of T cells (HP:0002843)3.74576426
11Cerebral palsy (HP:0100021)3.56451047
12Elevated erythrocyte sedimentation rate (HP:0003565)3.51440730
13Abnormality of eosinophils (HP:0001879)3.50558194
14Recurrent cutaneous fungal infections (HP:0011370)3.46831563
15Chronic mucocutaneous candidiasis (HP:0002728)3.46831563
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.45814827
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.42967083
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.42967083
19Combined immunodeficiency (HP:0005387)3.36736305
20Increased intramyocellular lipid droplets (HP:0012240)3.31166905
21Hemiplegia (HP:0002301)3.26500144
22Meningitis (HP:0001287)3.23602996
23Hypoplasia of the thymus (HP:0000778)3.18054808
24Recurrent fungal infections (HP:0002841)3.09486676
25Abnormality of macrophages (HP:0004311)3.06665497
26Encephalitis (HP:0002383)2.98804080
27B lymphocytopenia (HP:0010976)2.95397696
28Generalized aminoaciduria (HP:0002909)2.90613583
29Increased IgM level (HP:0003496)2.89839730
30Eosinophilia (HP:0001880)2.89636747
31Hepatocellular necrosis (HP:0001404)2.82235422
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.80147924
33Increased muscle lipid content (HP:0009058)2.72132919
34Recurrent viral infections (HP:0004429)2.69610835
35Abolished electroretinogram (ERG) (HP:0000550)2.64032142
36Hepatic necrosis (HP:0002605)2.58538303
37Abnormality of B cell number (HP:0010975)2.57282388
38Increased serum ferritin (HP:0003281)2.54321260
39Methylmalonic acidemia (HP:0002912)2.51419794
40Leukocytosis (HP:0001974)2.45400280
41Abnormal mitochondria in muscle tissue (HP:0008316)2.44600402
42Recurrent bacterial skin infections (HP:0005406)2.44584746
43Lymphopenia (HP:0001888)2.41437018
44Autoimmune hemolytic anemia (HP:0001890)2.35285019
45Methylmalonic aciduria (HP:0012120)2.33751654
46IgM deficiency (HP:0002850)2.32317952
47Recurrent skin infections (HP:0001581)2.31943692
48Panhypogammaglobulinemia (HP:0003139)2.31335682
49Decreased central vision (HP:0007663)2.31165923
50Increased IgE level (HP:0003212)2.30952204
51Granulocytopenia (HP:0001913)2.27713747
52Abnormality of the prostate (HP:0008775)2.27081839
53Tetraplegia (HP:0002445)2.26338421
54Chronic diarrhea (HP:0002028)2.25951637
55Bronchitis (HP:0012387)2.25468010
56Mediastinal lymphadenopathy (HP:0100721)2.24059773
573-Methylglutaconic aciduria (HP:0003535)2.23999749
58Pancytopenia (HP:0001876)2.22712064
59Stomatitis (HP:0010280)2.20559866
60Abnormal rod and cone electroretinograms (HP:0008323)2.19637116
61Mitochondrial inheritance (HP:0001427)2.17010925
62Abnormality of T cell physiology (HP:0011840)2.14886115
63Recurrent abscess formation (HP:0002722)2.12791139
64Lymphoma (HP:0002665)2.10868837
65Attenuation of retinal blood vessels (HP:0007843)2.09957490
66Spastic paraparesis (HP:0002313)2.09832430
67Chronic sinusitis (HP:0011109)2.08468505
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.08350832
69Acute hepatic failure (HP:0006554)2.08150168
70Conical tooth (HP:0000698)2.07303344
71Obstructive lung disease (HP:0006536)2.06057974
72Chronic obstructive pulmonary disease (HP:0006510)2.06057974
73Renal cortical cysts (HP:0000803)2.05760432
74Papilloma (HP:0012740)2.04952790
75Verrucae (HP:0200043)2.04952790
76Sepsis (HP:0100806)2.04476107
77Abnormality of transition element cation homeostasis (HP:0011030)2.03355135
78Dicarboxylic aciduria (HP:0003215)2.02406112
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02406112
80Abnormality of iron homeostasis (HP:0011031)1.99377792
81Failure to thrive in infancy (HP:0001531)1.99277002
82Rhabdomyolysis (HP:0003201)1.95295916
83Abnormal albumin level (HP:0012116)1.95110620
84Hypoalbuminemia (HP:0003073)1.95110620
85Alveolar cell carcinoma (HP:0006519)1.94099816
86Pustule (HP:0200039)1.94073559
87Amyotrophic lateral sclerosis (HP:0007354)1.93314644
88Mesangial abnormality (HP:0001966)1.92971547
89Exercise-induced myalgia (HP:0003738)1.87888915
90Palpebral edema (HP:0100540)1.87681529
91Cerebral edema (HP:0002181)1.86983880
92Periorbital edema (HP:0100539)1.86215615
93Pancreatitis (HP:0001733)1.86111648
94Radial bowing (HP:0002986)1.85909218
95Skin rash (HP:0000988)1.85500721
96Inflammation of the large intestine (HP:0002037)1.85368647
97Abnormality of the pleura (HP:0002103)1.85022173
98Progressive microcephaly (HP:0000253)1.84961014
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83683723
100Cerebral hypomyelination (HP:0006808)1.83661640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.00067552
2TESK24.93668814
3KDR4.56539072
4TXK4.20648074
5VRK22.98454222
6MAP3K112.94626885
7FES2.88878926
8LIMK12.81132358
9MAP4K12.37728395
10GRK62.35213951
11TESK12.30791188
12SCYL22.23347330
13MAP3K121.87997933
14TNK21.84320176
15MAPKAPK31.73752938
16ITK1.58946583
17KIT1.51752889
18NME21.38861292
19PINK11.37974941
20TYRO31.35223525
21TBK11.31991454
22LCK1.31021529
23SYK1.28572456
24ADRBK21.26988986
25PRKCQ1.26852510
26TLK11.22036539
27IKBKE1.18106509
28NUAK11.13375902
29IKBKB1.12914795
30BMPR21.11419055
31PIM21.09775813
32NME11.04713677
33DAPK21.01679138
34PIM11.00726587
35CSNK1G31.00514461
36VRK10.98807055
37ARAF0.98328212
38CSF1R0.98222325
39CSK0.98170154
40GRK10.97972662
41DAPK10.94906752
42BUB10.93741115
43MAPK110.90984278
44WNK40.90103948
45LYN0.88948193
46CCNB10.88469630
47GRK70.84862426
48BLK0.84595560
49PHKG20.76802988
50PHKG10.76802988
51CSNK1A1L0.76246171
52CSNK1G10.73226398
53CSNK1G20.71027970
54MAP2K70.67813165
55TAOK30.67018253
56RPS6KA40.66150952
57TEC0.65782868
58MAPKAPK20.63754808
59MAPK130.61344822
60AURKA0.61212775
61BTK0.60615192
62CSNK1A10.60543616
63FYN0.55841844
64CAMK2A0.53043194
65PIK3CG0.52402588
66TIE10.51258105
67JAK30.50018033
68RPS6KA50.49778636
69ILK0.48159644
70ZAP700.48038200
71MAP2K20.47636339
72CAMK2G0.47419263
73DAPK30.47068470
74TAOK20.45651909
75MYLK0.45630009
76LMTK20.45538802
77MAP3K10.45210324
78OBSCN0.43893698
79MINK10.43754138
80MAP4K20.43407972
81CHUK0.41448812
82ABL10.41244977
83IGF1R0.40771098
84MAP3K140.39694389
85PRKCA0.32749369
86MAP3K50.30606994
87ABL20.30394225
88JAK10.30210880
89INSR0.29981945
90CAMKK20.28287022
91INSRR0.27905146
92PRKACA0.27763989
93MAPK70.26845576
94CSNK1D0.26707720
95PIK3CA0.24591886
96NTRK20.24154610
97PTK2B0.23934266
98MST40.23356304
99MAP2K30.23323530
100LATS10.23014203

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.47598845
2Graft-versus-host disease_Homo sapiens_hsa053323.80163817
3Antigen processing and presentation_Homo sapiens_hsa046123.67222660
4Allograft rejection_Homo sapiens_hsa053303.50337976
5Autoimmune thyroid disease_Homo sapiens_hsa053203.46420176
6Proteasome_Homo sapiens_hsa030503.12878619
7Type I diabetes mellitus_Homo sapiens_hsa049402.79491974
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.76840468
9T cell receptor signaling pathway_Homo sapiens_hsa046602.48624514
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.46656641
11Hematopoietic cell lineage_Homo sapiens_hsa046402.16220174
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.15949537
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.12375767
14Oxidative phosphorylation_Homo sapiens_hsa001902.02368757
15Rheumatoid arthritis_Homo sapiens_hsa053231.95713245
16Viral myocarditis_Homo sapiens_hsa054161.79934325
17Asthma_Homo sapiens_hsa053101.77364161
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63690292
19Parkinsons disease_Homo sapiens_hsa050121.61308701
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46143230
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40157092
22Measles_Homo sapiens_hsa051621.36994131
23Sulfur relay system_Homo sapiens_hsa041221.35232618
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32889471
25RNA polymerase_Homo sapiens_hsa030201.23428765
26Shigellosis_Homo sapiens_hsa051311.21656582
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19005581
28Alzheimers disease_Homo sapiens_hsa050101.17588777
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11427566
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.10421722
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98573271
32Caffeine metabolism_Homo sapiens_hsa002320.94389319
33Systemic lupus erythematosus_Homo sapiens_hsa053220.86904667
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83570580
35B cell receptor signaling pathway_Homo sapiens_hsa046620.82597480
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81760318
37Staphylococcus aureus infection_Homo sapiens_hsa051500.81557800
38Sulfur metabolism_Homo sapiens_hsa009200.76752732
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75913101
40Nicotine addiction_Homo sapiens_hsa050330.73885007
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72114405
42Huntingtons disease_Homo sapiens_hsa050160.71020398
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70386380
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69395776
45Fatty acid biosynthesis_Homo sapiens_hsa000610.68248524
46Leishmaniasis_Homo sapiens_hsa051400.66653687
47Fanconi anemia pathway_Homo sapiens_hsa034600.65556663
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64285950
49Arachidonic acid metabolism_Homo sapiens_hsa005900.62518003
50Herpes simplex infection_Homo sapiens_hsa051680.62264460
51Phototransduction_Homo sapiens_hsa047440.61975135
52Prion diseases_Homo sapiens_hsa050200.61764525
53Salmonella infection_Homo sapiens_hsa051320.60061468
54Epstein-Barr virus infection_Homo sapiens_hsa051690.58983610
55Cardiac muscle contraction_Homo sapiens_hsa042600.58926021
56Synaptic vesicle cycle_Homo sapiens_hsa047210.58366394
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58347033
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57668525
59Osteoclast differentiation_Homo sapiens_hsa043800.57464547
60Protein export_Homo sapiens_hsa030600.57131481
61Nitrogen metabolism_Homo sapiens_hsa009100.53944989
62Linoleic acid metabolism_Homo sapiens_hsa005910.51403646
63TNF signaling pathway_Homo sapiens_hsa046680.51254381
64Chemokine signaling pathway_Homo sapiens_hsa040620.51105710
65Taste transduction_Homo sapiens_hsa047420.50468310
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49029504
67Purine metabolism_Homo sapiens_hsa002300.48675978
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48298190
69Homologous recombination_Homo sapiens_hsa034400.48250587
70Morphine addiction_Homo sapiens_hsa050320.47536769
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45175807
72Malaria_Homo sapiens_hsa051440.44640509
73Peroxisome_Homo sapiens_hsa041460.44532279
74Tuberculosis_Homo sapiens_hsa051520.43337164
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41184204
76Collecting duct acid secretion_Homo sapiens_hsa049660.40723143
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39118336
78Endocytosis_Homo sapiens_hsa041440.38950764
79Apoptosis_Homo sapiens_hsa042100.37594536
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36037806
81Amphetamine addiction_Homo sapiens_hsa050310.34292865
82Ribosome_Homo sapiens_hsa030100.33620390
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32688413
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.32596908
85Pertussis_Homo sapiens_hsa051330.31458855
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31077750
87Phagosome_Homo sapiens_hsa041450.30158127
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29261727
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29129848
90Pyrimidine metabolism_Homo sapiens_hsa002400.29050898
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.28851650
92Lysosome_Homo sapiens_hsa041420.27507687
93GABAergic synapse_Homo sapiens_hsa047270.27227899
94Propanoate metabolism_Homo sapiens_hsa006400.24531133
95HTLV-I infection_Homo sapiens_hsa051660.23788905
96Chemical carcinogenesis_Homo sapiens_hsa052040.23177274
97Salivary secretion_Homo sapiens_hsa049700.23159688
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.19092837
99ABC transporters_Homo sapiens_hsa020100.17784635
100Legionellosis_Homo sapiens_hsa051340.16951566

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