RAB21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)4.60235164
2regulation of glucokinase activity (GO:0033131)4.49056274
3regulation of hexokinase activity (GO:1903299)4.49056274
4protein localization to endosome (GO:0036010)4.19251776
5signal peptide processing (GO:0006465)4.15667505
6positive regulation of protein autophosphorylation (GO:0031954)3.76852386
7L-fucose catabolic process (GO:0042355)3.67253545
8fucose catabolic process (GO:0019317)3.67253545
9L-fucose metabolic process (GO:0042354)3.67253545
10establishment of protein localization to Golgi (GO:0072600)3.64692001
11growth hormone receptor signaling pathway (GO:0060396)3.59776401
12keratinocyte development (GO:0003334)3.49620129
13regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.43008119
14polyol catabolic process (GO:0046174)3.32743627
15cytoplasmic mRNA processing body assembly (GO:0033962)3.29306229
16regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.27026335
17cellular ketone body metabolic process (GO:0046950)3.25536440
18water-soluble vitamin biosynthetic process (GO:0042364)3.15027736
19negative regulation of execution phase of apoptosis (GO:1900118)3.13978356
20regulation of type B pancreatic cell apoptotic process (GO:2000674)3.13872912
21inositol phosphate catabolic process (GO:0071545)3.10347830
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.05731018
23indole-containing compound catabolic process (GO:0042436)3.03137999
24indolalkylamine catabolic process (GO:0046218)3.03137999
25tryptophan catabolic process (GO:0006569)3.03137999
26ketone body metabolic process (GO:1902224)3.02991382
27inositol phosphate-mediated signaling (GO:0048016)3.02476133
28UDP-N-acetylglucosamine metabolic process (GO:0006047)2.98913171
29cellular response to growth hormone stimulus (GO:0071378)2.98469795
30insulin secretion (GO:0030073)2.93918353
31proline transport (GO:0015824)2.91219856
32Golgi to endosome transport (GO:0006895)2.91092954
33inositol phosphate dephosphorylation (GO:0046855)2.85076952
34phosphorylated carbohydrate dephosphorylation (GO:0046838)2.85076952
35lactate metabolic process (GO:0006089)2.84275298
36prostate gland growth (GO:0060736)2.83919877
37protein K63-linked deubiquitination (GO:0070536)2.83350665
38protein localization to Golgi apparatus (GO:0034067)2.82285167
39response to pheromone (GO:0019236)2.81430620
40detection of light stimulus involved in visual perception (GO:0050908)2.81139651
41detection of light stimulus involved in sensory perception (GO:0050962)2.81139651
42antigen processing and presentation of endogenous antigen (GO:0019883)2.80450372
43kynurenine metabolic process (GO:0070189)2.77272557
44regulation of T-helper 1 cell differentiation (GO:0045625)2.73858245
45indolalkylamine metabolic process (GO:0006586)2.73826292
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73154873
47respiratory chain complex IV assembly (GO:0008535)2.73048392
48negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.72019584
49protein prenylation (GO:0018342)2.68007994
50prenylation (GO:0097354)2.68007994
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66462556
52negative regulation of cell killing (GO:0031342)2.66462556
53establishment of endothelial barrier (GO:0061028)2.65321524
54macroautophagy (GO:0016236)2.64101034
55cell adhesion mediated by integrin (GO:0033627)2.64080821
56nerve growth factor signaling pathway (GO:0038180)2.62021176
57interleukin-6-mediated signaling pathway (GO:0070102)2.60392067
58DNA deamination (GO:0045006)2.59177578
59kidney morphogenesis (GO:0060993)2.59124605
60adaptation of signaling pathway (GO:0023058)2.57234212
61positive regulation of p38MAPK cascade (GO:1900745)2.57108218
62magnesium ion transport (GO:0015693)2.56017260
63glycerophospholipid catabolic process (GO:0046475)2.55627794
64dopamine transport (GO:0015872)2.55008529
65tryptophan metabolic process (GO:0006568)2.54116294
66skin morphogenesis (GO:0043589)2.53750075
67reflex (GO:0060004)2.53692790
68negative regulation of systemic arterial blood pressure (GO:0003085)2.53541614
69regulation of protein autophosphorylation (GO:0031952)2.52381361
70regulation of MHC class II biosynthetic process (GO:0045346)2.51623012
71sodium ion export (GO:0071436)2.50519452
72early endosome to late endosome transport (GO:0045022)2.49917892
73positive regulation of glycolytic process (GO:0045821)2.49395595
74antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48837178
75antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48837178
76JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.48486920
77cyclic nucleotide catabolic process (GO:0009214)2.46763001
78plasma membrane repair (GO:0001778)2.46380953
79negative regulation of mast cell activation (GO:0033004)2.44482766
80DNA double-strand break processing (GO:0000729)2.43550118
81regulation of neurotransmitter uptake (GO:0051580)2.42303007
82photoreceptor cell maintenance (GO:0045494)2.42147695
83regulation of translation, ncRNA-mediated (GO:0045974)2.42144309
84negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42144309
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.42144309
86phasic smooth muscle contraction (GO:0014821)2.40789181
87regulation of protein glycosylation (GO:0060049)2.40268615
88positive regulation of macroautophagy (GO:0016239)2.39390968
89phosphatidylinositol acyl-chain remodeling (GO:0036149)2.39297579
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.39249422
91negative regulation of smooth muscle cell differentiation (GO:0051151)2.38572865
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38335234
93endocrine pancreas development (GO:0031018)2.37381707
94cAMP catabolic process (GO:0006198)2.37328505
95regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.36151807
96positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.36151807
97negative regulation of neurological system process (GO:0031645)2.34983179
98response to nerve growth factor (GO:1990089)2.34871994
99cellular response to nerve growth factor stimulus (GO:1990090)2.34871994
100positive regulation of natural killer cell differentiation (GO:0032825)2.34756900
101detection of calcium ion (GO:0005513)2.34247652
102negative regulation of neurotransmitter transport (GO:0051589)2.34113012
103positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.33355938
104cellular response to zinc ion (GO:0071294)2.32769883
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.32113983
106intestinal epithelial cell development (GO:0060576)2.31442651
107cellular response to ATP (GO:0071318)2.31192181
108parental behavior (GO:0060746)2.30721174
109positive regulation of histone deacetylation (GO:0031065)2.30507565
110thyroid hormone metabolic process (GO:0042403)2.28954954
111positive regulation of glycoprotein biosynthetic process (GO:0010560)2.28757456
112regulation of energy homeostasis (GO:2000505)2.28587937
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28442911
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.28242656
115granulocyte activation (GO:0036230)2.26348872
116intra-Golgi vesicle-mediated transport (GO:0006891)2.25163347
117positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.24339092
118neutrophil activation (GO:0042119)2.24036519
119negative regulation of JUN kinase activity (GO:0043508)2.23893258
120platelet dense granule organization (GO:0060155)2.23281415
121positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.22560187
122regulation of memory T cell differentiation (GO:0043380)2.21842514
123snRNA transcription (GO:0009301)2.21250225
124regulation of macrophage cytokine production (GO:0010935)2.20897474
125piRNA metabolic process (GO:0034587)2.20440384
126nitric oxide mediated signal transduction (GO:0007263)2.20323872
127zinc ion transport (GO:0006829)2.20249335
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.19382963
129negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.18681259
130cellular response to ethanol (GO:0071361)2.18304053
131hepatocyte apoptotic process (GO:0097284)2.18134679
132regulation of p38MAPK cascade (GO:1900744)2.17646050
133neutrophil activation involved in immune response (GO:0002283)2.17185435
134peristalsis (GO:0030432)2.16885474
135stress fiber assembly (GO:0043149)2.15340274
136cortical actin cytoskeleton organization (GO:0030866)2.13412016
137positive regulation of macrophage cytokine production (GO:0060907)2.12836146
138negative regulation of potassium ion transmembrane transport (GO:1901380)2.12552986
139regulation of clathrin-mediated endocytosis (GO:2000369)2.12383896
140Rap protein signal transduction (GO:0032486)2.12064248
141positive regulation of Rap GTPase activity (GO:0032854)2.11632729
142positive regulation of T-helper cell differentiation (GO:0045624)2.11605081
143endocytic recycling (GO:0032456)2.11562640
144hypotonic response (GO:0006971)2.11011256
145regulation of ARF protein signal transduction (GO:0032012)2.09668545
146myeloid dendritic cell differentiation (GO:0043011)2.08804538
147regulation of T-helper 2 cell differentiation (GO:0045628)2.08745879
148regulation of membrane protein ectodomain proteolysis (GO:0051043)2.08282646
149desmosome organization (GO:0002934)2.06597880
150regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.05727414
151cellular response to interferon-alpha (GO:0035457)2.05131051
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.03489213
153positive regulation by organism of defense response of other organism involved in symbiotic interact2.03489213
154modulation by symbiont of host immune response (GO:0052553)2.03489213
155positive regulation by symbiont of host defense response (GO:0052509)2.03489213
156modulation by symbiont of host defense response (GO:0052031)2.03489213
157modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.03489213
158regulation of T-helper cell differentiation (GO:0045622)2.01667548
159creatine metabolic process (GO:0006600)1.97609288
160negative regulation of fatty acid transport (GO:2000192)1.96763251
161regulation of macrophage chemotaxis (GO:0010758)1.96293589
162positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)1.95843474
163signal complex assembly (GO:0007172)1.93405393
164NIK/NF-kappaB signaling (GO:0038061)1.92277763
165negative regulation of cardiac muscle tissue growth (GO:0055022)1.91932459
166negative regulation of heart growth (GO:0061117)1.91932459
167regulation of hypersensitivity (GO:0002883)1.91537633
168regulation of interferon-beta biosynthetic process (GO:0045357)1.90122047
169T-helper 1 type immune response (GO:0042088)1.89111628
170protein targeting to Golgi (GO:0000042)1.88965984
171response to laminar fluid shear stress (GO:0034616)1.88962263
172positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.88002595
173localization within membrane (GO:0051668)1.86660715
174regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)1.85386792
175cortical cytoskeleton organization (GO:0030865)1.85083044
176response to muramyl dipeptide (GO:0032495)1.84760397
177dendritic cell differentiation (GO:0097028)1.84752980
178thymic T cell selection (GO:0045061)1.83173757
179cytoskeletal anchoring at plasma membrane (GO:0007016)1.83044046
180negative regulation of T-helper cell differentiation (GO:0045623)1.82837346
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)1.82837346
182potassium ion import (GO:0010107)1.82129351
183adhesion of symbiont to host cell (GO:0044650)1.81817961
184virion attachment to host cell (GO:0019062)1.81817961
185regulation of tight junction assembly (GO:2000810)1.81466384
186respiratory burst (GO:0045730)1.80945376
187relaxation of cardiac muscle (GO:0055119)1.79929362
188positive regulation of lamellipodium assembly (GO:0010592)1.79892687
189cellular potassium ion homeostasis (GO:0030007)1.79772612
190positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.79176113
191activation of JUN kinase activity (GO:0007257)1.78282845
192cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.78020951
193regulation of activation of Janus kinase activity (GO:0010533)1.77910679
194endothelial cell development (GO:0001885)1.77285036
195membrane raft organization (GO:0031579)1.77135518
196ruffle organization (GO:0031529)1.74910823
197positive regulation of T cell cytokine production (GO:0002726)1.74600431
198platelet-derived growth factor receptor signaling pathway (GO:0048008)1.74381956
199positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)1.74128791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13017724
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03831258
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.98299404
4GBX2_23144817_ChIP-Seq_PC3_Human2.86272691
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82652844
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77948267
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75052606
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68483646
9VDR_22108803_ChIP-Seq_LS180_Human2.56181761
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53546245
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.44428470
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.37627291
13ZNF274_21170338_ChIP-Seq_K562_Hela2.30800896
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28370473
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.26068091
16TAF15_26573619_Chip-Seq_HEK293_Human2.22575305
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.17021006
18* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.15767382
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.13080100
20P300_19829295_ChIP-Seq_ESCs_Human2.10065354
21EWS_26573619_Chip-Seq_HEK293_Human2.09599615
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02070803
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97449545
24FUS_26573619_Chip-Seq_HEK293_Human1.91528912
25ER_23166858_ChIP-Seq_MCF-7_Human1.88487206
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.83214479
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82419827
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80629693
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78113337
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.77372379
31* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75932220
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74750871
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73949053
34SMAD4_21799915_ChIP-Seq_A2780_Human1.72775345
35RUNX_20019798_ChIP-Seq_JUKART_Human1.72607987
36* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71425846
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69922719
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.69688254
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66732244
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66282362
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65956628
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65827537
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64499188
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63191105
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.62283550
46IGF1R_20145208_ChIP-Seq_DFB_Human1.58019426
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57630062
48STAT3_23295773_ChIP-Seq_U87_Human1.57375162
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57220692
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.56422221
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55564218
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53774600
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.52482086
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.52122773
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51610572
56* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50411202
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50287974
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49244540
59BCAT_22108803_ChIP-Seq_LS180_Human1.49161848
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49149363
61VDR_24787735_ChIP-Seq_THP-1_Human1.47968541
62AR_25329375_ChIP-Seq_VCAP_Human1.47830621
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47531749
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46430895
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46430895
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46375236
67CDX2_22108803_ChIP-Seq_LS180_Human1.45668192
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45514530
69TCF4_23295773_ChIP-Seq_U87_Human1.44809498
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44725952
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.43794585
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43785525
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42648746
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41936001
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40847578
76* CRX_20693478_ChIP-Seq_RETINA_Mouse1.40621122
77CBP_20019798_ChIP-Seq_JUKART_Human1.39819794
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39819794
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.39113058
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38050932
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37587951
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37303961
83* CJUN_26792858_Chip-Seq_BT549_Human1.36925269
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.36893400
85P53_22387025_ChIP-Seq_ESCs_Mouse1.35866001
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.33004562
87CLOCK_20551151_ChIP-Seq_293T_Human1.30800404
88* FLI1_21867929_ChIP-Seq_TH2_Mouse1.29896612
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29497875
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29225230
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28635953
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27639418
93KDM2B_26808549_Chip-Seq_DND41_Human1.27011521
94AR_21572438_ChIP-Seq_LNCaP_Human1.26462588
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.26070763
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26039010
97RXR_22108803_ChIP-Seq_LS180_Human1.24534881
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24433313
99SOX2_19829295_ChIP-Seq_ESCs_Human1.23791787
100NANOG_19829295_ChIP-Seq_ESCs_Human1.23791787
101TCF4_22108803_ChIP-Seq_LS180_Human1.23543911
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.23249542
103* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23068054
104TP53_16413492_ChIP-PET_HCT116_Human1.22988898
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.21521676
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.21483396
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21198401
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20759408
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19843833
110* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19406873
111TP53_18474530_ChIP-ChIP_U2OS_Human1.18767397
112EGR1_19374776_ChIP-ChIP_THP-1_Human1.18616006
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.18091215
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.18091215
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17427499
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.17330739
117KDM2B_26808549_Chip-Seq_K562_Human1.17089671
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.16733350
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16729270
120* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16339234
121P300_18555785_Chip-Seq_ESCs_Mouse1.16001150
122* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15760365
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15538018
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.14931195
125TP63_23658742_ChIP-Seq_EP156T_Human1.14327644
126SOX2_20726797_ChIP-Seq_SW620_Human1.13694250
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12669667
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.12599317
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11717365
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11247017
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10918575
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10834041
133SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10559951
134* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10385518
135TCF7_22412390_ChIP-Seq_EML_Mouse1.09447956
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09293158
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09293158
138RUNX2_22187159_ChIP-Seq_PCA_Human1.08886362
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.08505310
140FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08209811
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07035025
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06952238
143KDM2B_26808549_Chip-Seq_JURKAT_Human1.06841305
144NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06639820
145OCT4_18555785_Chip-Seq_ESCs_Mouse1.06424446
146NMYC_18555785_Chip-Seq_ESCs_Mouse1.05768116
147EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04689175
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04526267
149BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03948472
150P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03491218
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01663011
152MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01459274
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00841935
154AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99681303
155* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99571582
156TP53_22573176_ChIP-Seq_HFKS_Human0.99314895
157LXR_22158963_ChIP-Seq_LIVER_Mouse0.98107268
158KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97907556
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97726859
160AHR_22903824_ChIP-Seq_MCF-7_Human0.97268034
161MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96385791
162JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96251037
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95285223
164SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94523765
165SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94523765
166TCF4_18268006_ChIP-ChIP_LS174T_Human0.94290345
167PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93771081
168MAF_26560356_Chip-Seq_TH1_Human0.92016721
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.91914326
170JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91339660
171ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91028654
172MYB_26560356_Chip-Seq_TH2_Human0.90933973
173SPI1_23127762_ChIP-Seq_K562_Human0.90644794
174VDR_24763502_ChIP-Seq_THP-1_Human0.90597928
175ELK3_25401928_ChIP-Seq_HUVEC_Human0.90220359
176PU_27001747_Chip-Seq_BMDM_Mouse0.89757433
177* GATA2_19941826_ChIP-Seq_K562_Human0.89697824
178FOXA2_19822575_ChIP-Seq_HepG2_Human0.89247778
179ZNF263_19887448_ChIP-Seq_K562_Human0.89070522
180EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88390789
181WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87875783
182SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86626294
183ARNT_22903824_ChIP-Seq_MCF-7_Human0.86430784
184THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86100953
185GATA3_27048872_Chip-Seq_THYMUS_Human0.86092429
186NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85131350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.78335096
2MP0000569_abnormal_digit_pigmentation3.91457556
3MP0003303_peritoneal_inflammation3.53418200
4MP0004510_myositis3.01386402
5MP0008057_abnormal_DNA_replication2.85675449
6MP0002877_abnormal_melanocyte_morpholog2.85586720
7MP0003300_gastrointestinal_ulcer2.85129276
8MP0010234_abnormal_vibrissa_follicle2.69771421
9MP0008877_abnormal_DNA_methylation2.61146678
10MP0003705_abnormal_hypodermis_morpholog2.31864438
11MP0006072_abnormal_retinal_apoptosis2.29475503
12MP0001348_abnormal_lacrimal_gland2.27159505
13MP0000427_abnormal_hair_cycle2.27097557
14MP0004215_abnormal_myocardial_fiber2.25134473
15MP0003787_abnormal_imprinting2.21707297
16MP0000685_abnormal_immune_system2.19495895
17MP0005387_immune_system_phenotype2.18980716
18MP0001790_abnormal_immune_system2.18980716
19MP0002254_reproductive_system_inflammat2.07596421
20MP0005275_abnormal_skin_tensile2.06892987
21MP0006054_spinal_hemorrhage2.01656209
22MP0001835_abnormal_antigen_presentation1.96516741
23MP0004043_abnormal_pH_regulation1.95401902
24MP0002837_dystrophic_cardiac_calcinosis1.93880109
25MP0003436_decreased_susceptibility_to1.91425304
26MP0005551_abnormal_eye_electrophysiolog1.88413407
27MP0002102_abnormal_ear_morphology1.87091290
28MP0001501_abnormal_sleep_pattern1.85176918
29MP0003566_abnormal_cell_adhesion1.84776479
30MP0009046_muscle_twitch1.83987213
31MP0003091_abnormal_cell_migration1.82178761
32MP0005379_endocrine/exocrine_gland_phen1.81234524
33MP0005646_abnormal_pituitary_gland1.80274909
34MP0006082_CNS_inflammation1.76869367
35MP0002166_altered_tumor_susceptibility1.73651246
36MP0002909_abnormal_adrenal_gland1.71552754
37MP0002693_abnormal_pancreas_physiology1.71397587
38MP0003453_abnormal_keratinocyte_physiol1.68929450
39MP0002163_abnormal_gland_morphology1.68255729
40MP0008438_abnormal_cutaneous_collagen1.66649719
41MP0002876_abnormal_thyroid_physiology1.66380995
42MP0005174_abnormal_tail_pigmentation1.66377661
43MP0001346_abnormal_lacrimal_gland1.65788338
44MP0004947_skin_inflammation1.64995560
45MP0005000_abnormal_immune_tolerance1.62650835
46MP0005623_abnormal_meninges_morphology1.60550042
47MP0010352_gastrointestinal_tract_polyps1.59553887
48MP0003950_abnormal_plasma_membrane1.58388942
49MP0000383_abnormal_hair_follicle1.56537070
50MP0009384_cardiac_valve_regurgitation1.56438163
51MP0005253_abnormal_eye_physiology1.56321329
52MP0004185_abnormal_adipocyte_glucose1.55826232
53MP0005645_abnormal_hypothalamus_physiol1.54077946
54MP0003045_fibrosis1.53556477
55MP0005076_abnormal_cell_differentiation1.51375288
56MP0004130_abnormal_muscle_cell1.48777579
57MP0002006_tumorigenesis1.48694555
58MP0000372_irregular_coat_pigmentation1.45081524
59MP0003646_muscle_fatigue1.44882958
60MP0001533_abnormal_skeleton_physiology1.43627276
61MP0003075_altered_response_to1.43499941
62MP0003828_pulmonary_edema1.42766927
63MP0000579_abnormal_nail_morphology1.41338921
64MP0001944_abnormal_pancreas_morphology1.40106700
65MP0001800_abnormal_humoral_immune1.39451988
66MP0002090_abnormal_vision1.36005581
67MP0002796_impaired_skin_barrier1.34300491
68MP0002009_preneoplasia1.32895609
69MP0002928_abnormal_bile_duct1.29450121
70MP0000733_abnormal_muscle_development1.28568159
71MP0004087_abnormal_muscle_fiber1.27039298
72MP0009745_abnormal_behavioral_response1.26883903
73MP0002419_abnormal_innate_immunity1.26001938
74MP0009785_altered_susceptibility_to1.24844987
75MP0001485_abnormal_pinna_reflex1.24794453
76MP0002148_abnormal_hypersensitivity_rea1.23332648
77MP0000604_amyloidosis1.23212061
78MP0003448_altered_tumor_morphology1.23140214
79MP0005310_abnormal_salivary_gland1.22998543
80MP0009780_abnormal_chondrocyte_physiolo1.22672343
81MP0002452_abnormal_antigen_presenting1.22392828
82MP0003724_increased_susceptibility_to1.22213487
83MP0005220_abnormal_exocrine_pancreas1.19046256
84MP0000015_abnormal_ear_pigmentation1.18605283
85MP0003279_aneurysm1.18468793
86MP0002138_abnormal_hepatobiliary_system1.18253061
87MP0001851_eye_inflammation1.16462629
88MP0008872_abnormal_physiological_respon1.16009734
89MP0001958_emphysema1.15640738
90MP0002723_abnormal_immune_serum1.15278350
91MP0004885_abnormal_endolymph1.14496539
92MP0005058_abnormal_lysosome_morphology1.14472072
93MP0005025_abnormal_response_to1.13434227
94MP0000516_abnormal_urinary_system1.13258333
95MP0005367_renal/urinary_system_phenotyp1.13258333
96MP0004142_abnormal_muscle_tone1.12913832
97MP0005386_behavior/neurological_phenoty1.12376426
98MP0004924_abnormal_behavior1.12376426
99MP0002972_abnormal_cardiac_muscle1.12328543
100MP0002998_abnormal_bone_remodeling1.11069537
101MP0000920_abnormal_myelination1.10730952
102MP0005084_abnormal_gallbladder_morpholo1.09178616
103MP0002638_abnormal_pupillary_reflex1.08251971
104MP0008775_abnormal_heart_ventricle1.07674168
105MP0004084_abnormal_cardiac_muscle1.06890948
106MP0010678_abnormal_skin_adnexa1.06788973
107MP0002971_abnormal_brown_adipose1.06780577
108MP0008875_abnormal_xenobiotic_pharmacok1.04708503
109MP0004036_abnormal_muscle_relaxation1.02537466
110MP0001984_abnormal_olfaction1.01989335
111MP0003633_abnormal_nervous_system1.01479504
112MP0001756_abnormal_urination1.01017028
113MP0001819_abnormal_immune_cell1.00955865
114MP0002168_other_aberrant_phenotype1.00889207
115MP0002420_abnormal_adaptive_immunity1.00664595
116MP0010386_abnormal_urinary_bladder1.00578071
117MP0004484_altered_response_of1.00568214
118MP0003329_amyloid_beta_deposits0.99663911
119MP0005330_cardiomyopathy0.99248074
120MP0000750_abnormal_muscle_regeneration0.98886889
121MP0010630_abnormal_cardiac_muscle0.98472103
122MP0003690_abnormal_glial_cell0.96536356
123MP0002078_abnormal_glucose_homeostasis0.96493109
124MP0005023_abnormal_wound_healing0.95868031
125MP0005332_abnormal_amino_acid0.95322038
126MP0005167_abnormal_blood-brain_barrier0.94782744
127MP0001544_abnormal_cardiovascular_syste0.92526678
128MP0005385_cardiovascular_system_phenoty0.92526678
129MP0005266_abnormal_metabolism0.92131821
130MP0002933_joint_inflammation0.92018402
131MP0004085_abnormal_heartbeat0.90865507
132MP0010368_abnormal_lymphatic_system0.90466053
133MP0005165_increased_susceptibility_to0.90197548
134MP0009764_decreased_sensitivity_to0.89034290
135MP0002060_abnormal_skin_morphology0.88883781
136MP0000003_abnormal_adipose_tissue0.88314242
137MP0002405_respiratory_system_inflammati0.88251460
138MP0000230_abnormal_systemic_arterial0.87885024
139MP0001216_abnormal_epidermal_layer0.87778335
140MP0001845_abnormal_inflammatory_respons0.87700691
141MP0005671_abnormal_response_to0.87637759
142MP0005375_adipose_tissue_phenotype0.87277943
143MP0003011_delayed_dark_adaptation0.86274579
144MP0000751_myopathy0.85609318
145MP0002332_abnormal_exercise_endurance0.84327413
146MP0001853_heart_inflammation0.82733512
147MP0002272_abnormal_nervous_system0.82462944
148MP0006138_congestive_heart_failure0.81564165
149MP0005620_abnormal_muscle_contractility0.81192468
150MP0003283_abnormal_digestive_organ0.80439758
151MP0001881_abnormal_mammary_gland0.79637680
152MP0005166_decreased_susceptibility_to0.79566956
153MP0001299_abnormal_eye_distance/0.79244819
154MP0000343_altered_response_to0.79113370
155MP0005666_abnormal_adipose_tissue0.78844009
156MP0000013_abnormal_adipose_tissue0.78252897
157MP0000249_abnormal_blood_vessel0.77777974
158MP0002938_white_spotting0.77198603
159MP0003943_abnormal_hepatobiliary_system0.77032456
160MP0000538_abnormal_urinary_bladder0.75737374
161MP0003252_abnormal_bile_duct0.75367407
162MP0005389_reproductive_system_phenotype0.75117604
163MP0002277_abnormal_respiratory_mucosa0.74862198
164MP0005187_abnormal_penis_morphology0.74551866
165MP0001324_abnormal_eye_pigmentation0.72599484
166MP0003121_genomic_imprinting0.72119685
167MP0002229_neurodegeneration0.72080430
168MP0003137_abnormal_impulse_conducting0.70821217
169MP0002064_seizures0.70455392
170MP0004145_abnormal_muscle_electrophysio0.69634245
171MP0001919_abnormal_reproductive_system0.69064174
172MP0005647_abnormal_sex_gland0.68725105
173MP0000371_diluted_coat_color0.68328300
174MP0001486_abnormal_startle_reflex0.68148921
175MP0000647_abnormal_sebaceous_gland0.65605834
176MP0005448_abnormal_energy_balance0.65184769

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.81767307
2Congenital stationary night blindness (HP:0007642)3.55278730
3Pancreatic cysts (HP:0001737)3.55075764
4Hamartoma of the eye (HP:0010568)3.22756983
5Large for gestational age (HP:0001520)3.20241638
6Increased IgE level (HP:0003212)3.19617120
7Molar tooth sign on MRI (HP:0002419)3.16894389
8Abnormality of midbrain morphology (HP:0002418)3.16894389
9Hypothermia (HP:0002045)3.10291123
10Hyporeflexia of lower limbs (HP:0002600)3.08082149
11Gaze-evoked nystagmus (HP:0000640)3.07867344
12Pancreatic fibrosis (HP:0100732)2.93943279
13Right ventricular cardiomyopathy (HP:0011663)2.93747039
14Abnormality of the renal cortex (HP:0011035)2.91473928
15Ketoacidosis (HP:0001993)2.82477238
16Peritonitis (HP:0002586)2.79345008
17True hermaphroditism (HP:0010459)2.78979386
18Nephronophthisis (HP:0000090)2.77570945
19Fair hair (HP:0002286)2.76435832
20Furrowed tongue (HP:0000221)2.71137610
21Myocardial infarction (HP:0001658)2.68371231
22Febrile seizures (HP:0002373)2.67587784
23Hemiparesis (HP:0001269)2.64660442
24Tubular atrophy (HP:0000092)2.63013501
25Cerebral aneurysm (HP:0004944)2.62532884
26Abnormality of the renal medulla (HP:0100957)2.60280629
27Conjunctival hamartoma (HP:0100780)2.58728047
28Sudden death (HP:0001699)2.57966316
29Exercise-induced muscle cramps (HP:0003710)2.57057061
30Hyperinsulinemic hypoglycemia (HP:0000825)2.57026228
31Osteolytic defects of the hand bones (HP:0009699)2.56508123
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.56508123
33Premature rupture of membranes (HP:0001788)2.55706912
34Generalized hypopigmentation of hair (HP:0011358)2.49243721
35Recurrent bacterial skin infections (HP:0005406)2.47303227
36Progressive inability to walk (HP:0002505)2.47279813
37Hyperventilation (HP:0002883)2.47177383
38Attenuation of retinal blood vessels (HP:0007843)2.45993196
39Tetraparesis (HP:0002273)2.45663099
40Type II lissencephaly (HP:0007260)2.42773596
41Interstitial pulmonary disease (HP:0006530)2.41813005
42Papilledema (HP:0001085)2.41782068
43Polydipsia (HP:0001959)2.40323257
44Abnormal drinking behavior (HP:0030082)2.40323257
45Hypercortisolism (HP:0001578)2.37681658
46Hyperglycemia (HP:0003074)2.36124359
47Cellulitis (HP:0100658)2.33222592
48Recurrent abscess formation (HP:0002722)2.32387281
49Pheochromocytoma (HP:0002666)2.31542213
50Vascular tortuosity (HP:0004948)2.29791950
51Thyroiditis (HP:0100646)2.29615111
52Neurofibrillary tangles (HP:0002185)2.28867183
53Hypomagnesemia (HP:0002917)2.27915141
54Arterial tortuosity (HP:0005116)2.27709057
55Abnormality of vitamin B metabolism (HP:0004340)2.27061433
56Stomatitis (HP:0010280)2.26560741
57Gastrointestinal infarctions (HP:0005244)2.26092474
58Congenital sensorineural hearing impairment (HP:0008527)2.25382786
59Neuroendocrine neoplasm (HP:0100634)2.24588093
60Decreased circulating renin level (HP:0003351)2.24266349
61Recurrent fungal infections (HP:0002841)2.23817855
62Abnormal rod and cone electroretinograms (HP:0008323)2.23158153
63Medial flaring of the eyebrow (HP:0010747)2.22108197
64Chronic hepatic failure (HP:0100626)2.22032960
65Albinism (HP:0001022)2.22024798
66Hypoplasia of the fovea (HP:0007750)2.21422963
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.21422963
68Muscle fiber splitting (HP:0003555)2.20819539
69Aqueductal stenosis (HP:0002410)2.19394402
70Abnormality of alanine metabolism (HP:0010916)2.18581518
71Hyperalaninemia (HP:0003348)2.18581518
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18581518
73Renal cortical cysts (HP:0000803)2.15660096
74Hematochezia (HP:0002573)2.15161321
75Abnormality of macular pigmentation (HP:0008002)2.11862547
76Ventricular tachycardia (HP:0004756)2.11050953
77Cerebral inclusion bodies (HP:0100314)2.10504097
78Widely spaced teeth (HP:0000687)2.10463782
79Axonal loss (HP:0003447)2.10384768
80Autoimmune thrombocytopenia (HP:0001973)2.08357838
81Methylmalonic acidemia (HP:0002912)2.08313137
82Broad-based gait (HP:0002136)2.04992347
83Hypoglycemic seizures (HP:0002173)2.04940305
84Hypoglycemic coma (HP:0001325)2.02398954
85Tongue fasciculations (HP:0001308)2.02159678
86Difficulty running (HP:0009046)2.01492654
87Cortical dysplasia (HP:0002539)2.01337601
88Abnormality of macrophages (HP:0004311)2.01122640
89Asymmetric septal hypertrophy (HP:0001670)2.00708122
90Neoplasm of the adrenal cortex (HP:0100641)2.00092870
91Abnormal albumin level (HP:0012116)1.99746495
92Hypoalbuminemia (HP:0003073)1.99746495
93Urinary glycosaminoglycan excretion (HP:0003541)1.99641784
94Mucopolysacchariduria (HP:0008155)1.99641784
95Hypergammaglobulinemia (HP:0010702)1.98804007
96Intestinal atresia (HP:0011100)1.98574620
97Protrusio acetabuli (HP:0003179)1.98086634
98Abolished electroretinogram (ERG) (HP:0000550)1.97839688
99Recurrent skin infections (HP:0001581)1.96544243
100Exercise-induced myalgia (HP:0003738)1.95666193
101Inability to walk (HP:0002540)1.95239608
102Abnormality of the pons (HP:0007361)1.95066380
103Aortic dissection (HP:0002647)1.94084304
104Mitral valve prolapse (HP:0001634)1.93145183
105Abnormality of the fovea (HP:0000493)1.92732568
106Meningioma (HP:0002858)1.92539261
107Azoospermia (HP:0000027)1.92511787
108Chronic otitis media (HP:0000389)1.91522483
109Hypoplastic ischia (HP:0003175)1.90990181
110Verrucae (HP:0200043)1.90298945
111Papilloma (HP:0012740)1.90298945
112Macroorchidism (HP:0000053)1.89530362
113Ketosis (HP:0001946)1.88644685
114Dysostosis multiplex (HP:0000943)1.88615960
115Progressive cerebellar ataxia (HP:0002073)1.88394893
116Vasculitis (HP:0002633)1.88209179
117Supranuclear gaze palsy (HP:0000605)1.88192207
118Cerebral hemorrhage (HP:0001342)1.87223703
119Increased density of long bones (HP:0006392)1.86019173
120Increased cerebral lipofuscin (HP:0011813)1.85205613
121Enlarged penis (HP:0000040)1.85039872
122Termporal pattern (HP:0011008)1.83602329
123Insidious onset (HP:0003587)1.83602329
124Distal lower limb amyotrophy (HP:0008944)1.83042163
125Dilatation of the ascending aorta (HP:0005111)1.82934485
126Polycythemia (HP:0001901)1.82501552
127Breast carcinoma (HP:0003002)1.82453000
128Progressive macrocephaly (HP:0004481)1.81452269
129Hypoplasia of the pons (HP:0012110)1.81378388
130Abnormality of the left ventricular outflow tract (HP:0011103)1.81232234
131Subaortic stenosis (HP:0001682)1.81232234
132Recurrent viral infections (HP:0004429)1.81089419
133Aortic aneurysm (HP:0004942)1.80995608
134Colitis (HP:0002583)1.80941614
135Polyuria (HP:0000103)1.79861595
136Lower limb amyotrophy (HP:0007210)1.79837860
137Persistence of primary teeth (HP:0006335)1.79679271
138Recurrent gram-negative bacterial infections (HP:0005420)1.79241150
139Limb dystonia (HP:0002451)1.78866184
140Emphysema (HP:0002097)1.78848153
141Increased connective tissue (HP:0009025)1.78523693
142Genetic anticipation (HP:0003743)1.77965123
143Myositis (HP:0100614)1.77963776
144Protruding tongue (HP:0010808)1.77746389
145Osteomyelitis (HP:0002754)1.76895281
146Disinhibition (HP:0000734)1.76444219
147Achilles tendon contracture (HP:0001771)1.75592930
148EMG: myopathic abnormalities (HP:0003458)1.74797709
149Aneurysm (HP:0002617)1.73748224
150Shallow orbits (HP:0000586)1.72662998
151Arterial thrombosis (HP:0004420)1.71254483
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.70513505
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70291235
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70291235
155Abnormality of polysaccharide metabolism (HP:0011012)1.70291235
156Muscle fibrillation (HP:0010546)1.69642481
157Recurrent cutaneous fungal infections (HP:0011370)1.69620536
158Chronic mucocutaneous candidiasis (HP:0002728)1.69620536
159Atrophic scars (HP:0001075)1.69522402
160Scapular winging (HP:0003691)1.69240700
161Orchitis (HP:0100796)1.68288760
162Hypoproteinemia (HP:0003075)1.68186689
163Increased CSF protein (HP:0002922)1.67181198
164Abnormality of the Achilles tendon (HP:0005109)1.66657250
165Abnormal pancreas size (HP:0012094)1.66297442
166Absent speech (HP:0001344)1.65926723
167Volvulus (HP:0002580)1.65601766
168Stomach cancer (HP:0012126)1.65394645
169Ulnar bowing (HP:0003031)1.65102213
170Muscle hypertrophy of the lower extremities (HP:0008968)1.64576654
171Downturned corners of mouth (HP:0002714)1.64569425
172Keratoconus (HP:0000563)1.64293901
173Increased corneal curvature (HP:0100692)1.64293901
174Syncope (HP:0001279)1.63614791
175Hyperextensible skin (HP:0000974)1.63153010
176Calf muscle hypertrophy (HP:0008981)1.62983584
177Frequent falls (HP:0002359)1.62915689
178Cerebellar dysplasia (HP:0007033)1.62781324
179Abnormality of proline metabolism (HP:0010907)1.62447624
180Hydroxyprolinuria (HP:0003080)1.62447624
181Abnormality of the ischium (HP:0003174)1.61998842
182Hyperkalemia (HP:0002153)1.61892783
183Aplasia involving bones of the upper limbs (HP:0009823)1.61877222
184Aplasia of the phalanges of the hand (HP:0009802)1.61877222
185Aplasia involving bones of the extremities (HP:0009825)1.61877222
186Abnormal biliary tract morphology (HP:0012440)1.59503157
187Bundle branch block (HP:0011710)1.59387335
188Atrial fibrillation (HP:0005110)1.59380758
189Disproportionate tall stature (HP:0001519)1.59325572
190Abnormality of the vitamin B12 metabolism (HP:0004341)1.59288009
191Disproportionate short-trunk short stature (HP:0003521)1.59199484
192Striae distensae (HP:0001065)1.59059233
193Mitral stenosis (HP:0001718)1.58151632
194Thick nail (HP:0001805)1.58039356
195Rapidly progressive (HP:0003678)1.57585606
196Gastrointestinal stroma tumor (HP:0100723)1.57331383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.03641027
2EPHB13.01450210
3ACVR1B2.97198726
4MAP3K22.52348977
5DMPK2.43523518
6TRIB32.41793502
7BMPR1B2.40756652
8MKNK22.37707696
9EIF2AK32.36273376
10WNK32.08224611
11TTN2.04768668
12MAP3K142.03253247
13ADRBK22.00394798
14LATS11.99285965
15GRK11.90690609
16TAOK31.84319616
17SIK31.81952829
18EPHA31.80966501
19JAK11.79943028
20CASK1.73895905
21TNIK1.73589558
22MAP3K131.64089364
23MAP3K91.60977786
24MAP4K21.54163441
25NTRK31.51384542
26KSR21.51328323
27ERBB31.48212821
28RIPK41.46308724
29AKT31.44782816
30BMX1.43371531
31PAK31.43078126
32OXSR11.42928633
33LRRK21.41352699
34FGFR31.40999649
35PINK11.40158587
36STK38L1.40152180
37MAP3K31.39852318
38OBSCN1.38515788
39RIPK11.37985729
40FRK1.37761368
41TBK11.37308158
42TRPM71.35855799
43RET1.27336132
44STK101.26283552
45PTK61.25654832
46NUAK11.24802467
47TYK21.21319790
48FGFR41.18679081
49JAK31.18475345
50ERN11.16700353
51PLK21.15667495
52STK241.11001701
53STK31.10022053
54WNK11.09884941
55MAP3K11.09212990
56HIPK21.09007368
57BRSK21.08985884
58CSK1.07480862
59PKN21.06487117
60IRAK11.04525887
61MST41.03985594
62BCR1.01132532
63DAPK20.98879100
64MKNK10.98820899
65LATS20.95895570
66PRKD10.93099106
67PRKCQ0.92212226
68GRK60.92163147
69MAP3K60.92111993
70PRKCH0.91755143
71FER0.90822811
72JAK20.90709680
73PAK60.90412772
74TAOK10.89039720
75ZAK0.88436346
76MOS0.88051690
77MAPK130.88047853
78FGR0.87909532
79MAP3K40.87172403
80PDGFRA0.85555841
81NEK90.84999987
82ADRBK10.84876122
83CDK60.84074828
84PDPK10.83670455
85PTK20.83109424
86ITK0.82428455
87ALK0.81628130
88STK390.79654241
89SGK20.79357339
90IKBKB0.78433933
91PDGFRB0.78229269
92MAP4K10.78209724
93DDR20.77939112
94NTRK10.75470648
95IKBKE0.75155710
96HCK0.74321231
97ILK0.73999176
98TAF10.73200553
99ERBB40.72427819
100CAMKK20.72356943
101CHUK0.71884714
102FGFR20.71508866
103STK110.70869733
104EIF2AK10.70461955
105MAP3K70.69010135
106KSR10.68695318
107PDK10.68692318
108ROCK20.68455837
109MUSK0.68301219
110PRKD20.68088418
111PKN10.67784577
112BMPR20.67222565
113BLK0.63891845
114TGFBR10.62672186
115DYRK1B0.62312304
116FES0.62177808
117EGFR0.61552558
118SGK30.61435645
119PLK30.61319414
120TYRO30.61301766
121MAP3K50.61065120
122GRK70.60662783
123NLK0.57350726
124ABL10.57049886
125WNK40.55998342
126PIK3CA0.55896302
127EIF2AK20.55559698
128ROCK10.55037658
129INSRR0.53784595
130TXK0.53717920
131TGFBR20.53711322
132SYK0.53353160
133PRKAA20.53196649
134PHKG10.50513763
135PHKG20.50513763
136CAMK2D0.49949954
137MAP3K100.49739418
138YES10.48165151
139MAPK120.47872602
140LMTK20.47546905
141PTK2B0.46703800
142MAP3K120.46618081
143PRKCG0.45245183
144ABL20.44484770
145MARK30.44185419
146PIK3CG0.43838784
147CAMK2A0.43774274
148PRKCE0.43389697
149EEF2K0.42918689
150FYN0.42651694
151MELK0.42335558
152GSK3A0.41977817
153PNCK0.39658065
154PRKG10.37687979
155MAP2K60.37135358
156PRKCI0.35673815
157TEC0.34952755
158WEE10.34746121
159PRKAA10.33186590
160MYLK0.32899737
161BRD40.31995821
162MAPKAPK30.31480640
163TSSK60.30293448
164TLK10.30222587
165TNK20.28629313
166MAP2K10.27596834

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.60389116
2Protein export_Homo sapiens_hsa030602.56248110
3Butanoate metabolism_Homo sapiens_hsa006502.36465479
4Selenocompound metabolism_Homo sapiens_hsa004502.24672140
5Circadian rhythm_Homo sapiens_hsa047102.16839097
6Phototransduction_Homo sapiens_hsa047442.12695417
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07821754
8Propanoate metabolism_Homo sapiens_hsa006402.01587636
9Linoleic acid metabolism_Homo sapiens_hsa005911.99301978
10Insulin secretion_Homo sapiens_hsa049111.98682705
11Regulation of autophagy_Homo sapiens_hsa041401.92120602
12Nitrogen metabolism_Homo sapiens_hsa009101.91549235
13Ether lipid metabolism_Homo sapiens_hsa005651.89278780
14Vitamin B6 metabolism_Homo sapiens_hsa007501.88793738
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78124017
16Sulfur metabolism_Homo sapiens_hsa009201.74455038
17Tryptophan metabolism_Homo sapiens_hsa003801.74331247
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73914571
19Basal transcription factors_Homo sapiens_hsa030221.72135701
20Leishmaniasis_Homo sapiens_hsa051401.64326853
21Dorso-ventral axis formation_Homo sapiens_hsa043201.59868773
22Caffeine metabolism_Homo sapiens_hsa002321.57928305
23Osteoclast differentiation_Homo sapiens_hsa043801.56177981
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50618977
25Mineral absorption_Homo sapiens_hsa049781.49233717
26B cell receptor signaling pathway_Homo sapiens_hsa046621.44384920
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39269120
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38711127
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31821657
30Toxoplasmosis_Homo sapiens_hsa051451.31722309
31Renal cell carcinoma_Homo sapiens_hsa052111.22083621
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21810518
33Dilated cardiomyopathy_Homo sapiens_hsa054141.21208666
34TNF signaling pathway_Homo sapiens_hsa046681.20402660
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20263630
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.18011835
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17989342
38Chemokine signaling pathway_Homo sapiens_hsa040621.16454801
39Amoebiasis_Homo sapiens_hsa051461.16085418
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15790584
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.13954195
42Pancreatic cancer_Homo sapiens_hsa052121.13858954
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13542825
44Proteoglycans in cancer_Homo sapiens_hsa052051.13518095
45Viral myocarditis_Homo sapiens_hsa054161.13104223
46Collecting duct acid secretion_Homo sapiens_hsa049661.11674677
47Serotonergic synapse_Homo sapiens_hsa047261.10512255
48Focal adhesion_Homo sapiens_hsa045101.09059266
49VEGF signaling pathway_Homo sapiens_hsa043701.07691287
50Chronic myeloid leukemia_Homo sapiens_hsa052201.07456813
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07417299
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05979905
53Malaria_Homo sapiens_hsa051441.05433064
54ABC transporters_Homo sapiens_hsa020101.04541240
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04445602
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03380367
57Circadian entrainment_Homo sapiens_hsa047131.03008514
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.02445387
59Sphingolipid metabolism_Homo sapiens_hsa006001.02423539
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01806494
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.00797488
62Tuberculosis_Homo sapiens_hsa051521.00581997
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.99802002
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99418440
65RNA degradation_Homo sapiens_hsa030180.97546434
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97209584
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96496657
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95473915
69Ovarian steroidogenesis_Homo sapiens_hsa049130.95380255
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94432978
71Insulin resistance_Homo sapiens_hsa049310.93484658
72Platelet activation_Homo sapiens_hsa046110.92685690
73Glioma_Homo sapiens_hsa052140.92464419
74Prolactin signaling pathway_Homo sapiens_hsa049170.92096321
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.91427868
76Graft-versus-host disease_Homo sapiens_hsa053320.90856978
77T cell receptor signaling pathway_Homo sapiens_hsa046600.90459573
78Allograft rejection_Homo sapiens_hsa053300.88933292
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88712895
80MAPK signaling pathway_Homo sapiens_hsa040100.88336656
81mTOR signaling pathway_Homo sapiens_hsa041500.88066741
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87844362
83GnRH signaling pathway_Homo sapiens_hsa049120.87590169
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.87366585
85Amphetamine addiction_Homo sapiens_hsa050310.85437410
86Pertussis_Homo sapiens_hsa051330.85400178
87Salmonella infection_Homo sapiens_hsa051320.84816085
88Renin secretion_Homo sapiens_hsa049240.84498958
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84054059
90Endocytosis_Homo sapiens_hsa041440.83352487
91Taste transduction_Homo sapiens_hsa047420.82953386
92Shigellosis_Homo sapiens_hsa051310.82154640
93beta-Alanine metabolism_Homo sapiens_hsa004100.82141299
94Glutamatergic synapse_Homo sapiens_hsa047240.81400955
95Estrogen signaling pathway_Homo sapiens_hsa049150.81382457
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.80119326
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79831762
98Adherens junction_Homo sapiens_hsa045200.79767050
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79414231
100ErbB signaling pathway_Homo sapiens_hsa040120.79142910
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.79003056
102Dopaminergic synapse_Homo sapiens_hsa047280.78589875
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78446255
104Rheumatoid arthritis_Homo sapiens_hsa053230.78426839
105Morphine addiction_Homo sapiens_hsa050320.78401981
106Gastric acid secretion_Homo sapiens_hsa049710.78278141
107Fatty acid degradation_Homo sapiens_hsa000710.77913138
108Small cell lung cancer_Homo sapiens_hsa052220.77003104
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75633582
110Calcium signaling pathway_Homo sapiens_hsa040200.75092001
111Type II diabetes mellitus_Homo sapiens_hsa049300.74455514
112Acute myeloid leukemia_Homo sapiens_hsa052210.74066419
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.72458500
114Legionellosis_Homo sapiens_hsa051340.72136960
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72064933
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71408570
117ECM-receptor interaction_Homo sapiens_hsa045120.68883656
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68772982
119Non-small cell lung cancer_Homo sapiens_hsa052230.68236978
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67534879
121FoxO signaling pathway_Homo sapiens_hsa040680.67420061
122Lysosome_Homo sapiens_hsa041420.66425844
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66018317
124GABAergic synapse_Homo sapiens_hsa047270.65023350
125Long-term depression_Homo sapiens_hsa047300.64515509
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64250605
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64187198
128Ras signaling pathway_Homo sapiens_hsa040140.64110820
129Long-term potentiation_Homo sapiens_hsa047200.64011588
130Measles_Homo sapiens_hsa051620.63890156
131Choline metabolism in cancer_Homo sapiens_hsa052310.63285018
132Pancreatic secretion_Homo sapiens_hsa049720.63045634
133Hepatitis B_Homo sapiens_hsa051610.62845826
134Oxytocin signaling pathway_Homo sapiens_hsa049210.62227436
135Apoptosis_Homo sapiens_hsa042100.61285259
136African trypanosomiasis_Homo sapiens_hsa051430.60833421
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60823662
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60250474
139Salivary secretion_Homo sapiens_hsa049700.59926610
140Phagosome_Homo sapiens_hsa041450.59686162
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.59626792
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58504925
143Type I diabetes mellitus_Homo sapiens_hsa049400.58499563
144Arginine biosynthesis_Homo sapiens_hsa002200.57890237
145Peroxisome_Homo sapiens_hsa041460.57745859
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57296179
147One carbon pool by folate_Homo sapiens_hsa006700.56783495
148Glucagon signaling pathway_Homo sapiens_hsa049220.56287060
149Primary immunodeficiency_Homo sapiens_hsa053400.56090889
150cAMP signaling pathway_Homo sapiens_hsa040240.55988657
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55832444
152MicroRNAs in cancer_Homo sapiens_hsa052060.55736601
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55383987
154Olfactory transduction_Homo sapiens_hsa047400.55268681
155Endometrial cancer_Homo sapiens_hsa052130.55258225
156Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54970844
157Prostate cancer_Homo sapiens_hsa052150.54650645
158Lysine degradation_Homo sapiens_hsa003100.50621111
159Nicotine addiction_Homo sapiens_hsa050330.49323941
160Arachidonic acid metabolism_Homo sapiens_hsa005900.46751439
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46310208
162Retinol metabolism_Homo sapiens_hsa008300.46202381
163Non-homologous end-joining_Homo sapiens_hsa034500.45467103
164Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45282661
165Histidine metabolism_Homo sapiens_hsa003400.45253038
166Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39403869
167Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38556745
168TGF-beta signaling pathway_Homo sapiens_hsa043500.36879835
169Cholinergic synapse_Homo sapiens_hsa047250.34670798
170Glycerolipid metabolism_Homo sapiens_hsa005610.34508832
171Chemical carcinogenesis_Homo sapiens_hsa052040.33610659
172Inositol phosphate metabolism_Homo sapiens_hsa005620.32078707

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