RAB22A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.81016997
2regulation of type B pancreatic cell apoptotic process (GO:2000674)4.73418805
3positive regulation of protein autophosphorylation (GO:0031954)4.35902826
4water-soluble vitamin biosynthetic process (GO:0042364)4.02790905
5negative regulation of hormone biosynthetic process (GO:0032353)3.89957284
6inositol phosphate catabolic process (GO:0071545)3.73715637
7protein localization to endosome (GO:0036010)3.73577083
8regulation of hexokinase activity (GO:1903299)3.66941504
9regulation of glucokinase activity (GO:0033131)3.66941504
10Golgi transport vesicle coating (GO:0048200)3.64355039
11COPI coating of Golgi vesicle (GO:0048205)3.64355039
12plasma membrane repair (GO:0001778)3.59156949
13negative regulation of fatty acid transport (GO:2000192)3.42682148
14insulin secretion (GO:0030073)3.41163647
15positive regulation of receptor recycling (GO:0001921)3.34758301
16positive regulation of histone deacetylation (GO:0031065)3.33686522
17positive regulation of fatty acid beta-oxidation (GO:0032000)3.33364303
18negative regulation of hormone metabolic process (GO:0032351)3.26758850
19growth hormone receptor signaling pathway (GO:0060396)3.22139202
20Leydig cell differentiation (GO:0033327)3.19636784
21cellular ketone body metabolic process (GO:0046950)3.16165489
22polyol catabolic process (GO:0046174)3.15673412
23positive regulation of p38MAPK cascade (GO:1900745)3.13593522
24protein localization to cilium (GO:0061512)3.11215731
25phosphorylated carbohydrate dephosphorylation (GO:0046838)3.11029654
26inositol phosphate dephosphorylation (GO:0046855)3.11029654
27positive regulation of glycogen biosynthetic process (GO:0045725)3.09124765
28cell adhesion mediated by integrin (GO:0033627)3.07748753
29positive regulation of meiosis (GO:0045836)3.01145572
30protein prenylation (GO:0018342)2.99210844
31prenylation (GO:0097354)2.99210844
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.99073793
33regulation of fatty acid beta-oxidation (GO:0031998)2.97557470
34insulin-like growth factor receptor signaling pathway (GO:0048009)2.97460597
35positive regulation of glycolytic process (GO:0045821)2.97181924
36hemidesmosome assembly (GO:0031581)2.96996497
37keratinocyte development (GO:0003334)2.95544988
38desmosome organization (GO:0002934)2.94819487
39righting reflex (GO:0060013)2.94134997
40magnesium ion transport (GO:0015693)2.93239618
41regulation of p38MAPK cascade (GO:1900744)2.91890955
42negative regulation of neurological system process (GO:0031645)2.90706036
43skin morphogenesis (GO:0043589)2.90003058
44regulation of protein autophosphorylation (GO:0031952)2.89305732
45endocrine pancreas development (GO:0031018)2.89128048
46early endosome to late endosome transport (GO:0045022)2.89029286
47macroautophagy (GO:0016236)2.88953587
48relaxation of cardiac muscle (GO:0055119)2.88626547
49apoptotic cell clearance (GO:0043277)2.88163922
50positive regulation of macroautophagy (GO:0016239)2.87991698
51positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86401039
52cytoplasmic mRNA processing body assembly (GO:0033962)2.86255687
53ketone body metabolic process (GO:1902224)2.85515752
54regulation of protein glycosylation (GO:0060049)2.84932163
55negative regulation of dendrite development (GO:2000171)2.84571551
56positive regulation of meiotic cell cycle (GO:0051446)2.84454332
57plasma membrane fusion (GO:0045026)2.82810228
58positive regulation of fatty acid oxidation (GO:0046321)2.80971082
59nitric oxide mediated signal transduction (GO:0007263)2.80818425
60regulation of Rac protein signal transduction (GO:0035020)2.80411965
61parental behavior (GO:0060746)2.80407010
62vascular endothelial growth factor signaling pathway (GO:0038084)2.80205966
63dendritic spine morphogenesis (GO:0060997)2.80160809
64response to lipoprotein particle (GO:0055094)2.80100681
65fibroblast migration (GO:0010761)2.79837429
66negative regulation of axon extension involved in axon guidance (GO:0048843)2.79453176
67positive regulation of nuclease activity (GO:0032075)2.79142244
68cellular response to growth hormone stimulus (GO:0071378)2.76009857
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74963190
70regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.74387358
71signal peptide processing (GO:0006465)2.73989866
72lactate metabolic process (GO:0006089)2.73759110
73low-density lipoprotein particle clearance (GO:0034383)2.71993276
74lipid particle organization (GO:0034389)2.70075682
75brain morphogenesis (GO:0048854)2.67917163
76negative regulation of potassium ion transmembrane transport (GO:1901380)2.67560577
77epithelial cell fate commitment (GO:0072148)2.66410212
78negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65169071
79positive regulation of glycogen metabolic process (GO:0070875)2.63870509
80prostate gland growth (GO:0060736)2.63345370
81regulation of membrane protein ectodomain proteolysis (GO:0051043)2.61252270
82regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59383284
83protein heterotrimerization (GO:0070208)2.58882721
84stress fiber assembly (GO:0043149)2.58288598
85localization within membrane (GO:0051668)2.57944307
86regulation of non-canonical Wnt signaling pathway (GO:2000050)2.57816284
87lysine metabolic process (GO:0006553)2.57332696
88lysine catabolic process (GO:0006554)2.57332696
89COPII vesicle coating (GO:0048208)2.56570135
90melanosome transport (GO:0032402)2.56521224
91toxin metabolic process (GO:0009404)2.56264129
92positive regulation of cellular response to insulin stimulus (GO:1900078)2.55888251
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.55813843
94endoplasmic reticulum unfolded protein response (GO:0030968)2.54560053
95intraciliary transport (GO:0042073)2.51607945
964-hydroxyproline metabolic process (GO:0019471)2.50297781
97negative regulation of cell size (GO:0045792)2.50178631
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49712113
99detection of calcium ion (GO:0005513)2.48402215
100retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47707934
101regulation of nuclease activity (GO:0032069)2.47268334
102hippo signaling (GO:0035329)2.47124646
103positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.45918217
104cell-substrate junction assembly (GO:0007044)2.45874008
105establishment of melanosome localization (GO:0032401)2.45830479
106positive regulation of insulin secretion (GO:0032024)2.45545421
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.45488114
108pigment granule transport (GO:0051904)2.45372123
109cellular response to vitamin (GO:0071295)2.45176145
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.45044643
111cellular response to unfolded protein (GO:0034620)2.44884167
112positive regulation of actin filament depolymerization (GO:0030836)2.44543097
113regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.43990587
114cardiac myofibril assembly (GO:0055003)2.42923330
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.42353745
116zinc ion transport (GO:0006829)2.42163512
117negative regulation of dendrite morphogenesis (GO:0050774)2.41807129
118auditory receptor cell differentiation (GO:0042491)2.41071777
119dentate gyrus development (GO:0021542)2.40952382
120cellular response to vitamin D (GO:0071305)2.38085706
121ER-nucleus signaling pathway (GO:0006984)2.37780608
122regulation of acrosome reaction (GO:0060046)2.36302933
123regulation of fatty acid oxidation (GO:0046320)2.35953202
124establishment of pigment granule localization (GO:0051905)2.35630936
125startle response (GO:0001964)2.35180905
126embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35123044
127presynaptic membrane assembly (GO:0097105)2.34469673
128cellular response to ATP (GO:0071318)2.33910799
129regulation of steroid hormone biosynthetic process (GO:0090030)2.32443789
130protein localization to Golgi apparatus (GO:0034067)2.32292295
131regulation of cholesterol homeostasis (GO:2000188)2.32133952
132negative regulation of neurotransmitter transport (GO:0051589)2.30753452
133positive regulation of response to nutrient levels (GO:0032109)2.30226346
134positive regulation of response to extracellular stimulus (GO:0032106)2.30226346
135positive regulation of peptide hormone secretion (GO:0090277)2.29963036
136endodermal cell differentiation (GO:0035987)2.29942189
137glycosphingolipid biosynthetic process (GO:0006688)2.29603106
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29502415
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29362625
140cellular response to nutrient (GO:0031670)2.28751304
141regulation of glucose import in response to insulin stimulus (GO:2001273)2.28661426
142collagen fibril organization (GO:0030199)2.28526872
143melanosome localization (GO:0032400)2.28344990
144positive regulation of glycoprotein biosynthetic process (GO:0010560)2.27608081
145regulation of axon extension involved in axon guidance (GO:0048841)2.25463037
146negative regulation of acute inflammatory response (GO:0002674)2.25111717
147negative regulation of protein oligomerization (GO:0032460)2.24456668
148dopamine transport (GO:0015872)2.24270892
149regulation of polysaccharide biosynthetic process (GO:0032885)2.23893929
150peptide hormone processing (GO:0016486)2.23461735
151positive regulation of peptide secretion (GO:0002793)2.22531025
152cellular response to topologically incorrect protein (GO:0035967)2.22151644
153vesicle coating (GO:0006901)2.21968279
154intestinal epithelial cell development (GO:0060576)2.21569961
155regulation of dendritic spine development (GO:0060998)2.20879336
156cell migration involved in sprouting angiogenesis (GO:0002042)2.20737764
157protein targeting to Golgi (GO:0000042)2.20604328
158type B pancreatic cell development (GO:0003323)2.20217533
159pigment granule localization (GO:0051875)2.19660830
160fatty acid transmembrane transport (GO:1902001)2.19630460
161negative regulation of axon guidance (GO:1902668)2.18800207
162sarcomere organization (GO:0045214)2.18628987
163regulation of meiosis I (GO:0060631)2.18227753
164regulation of cholesterol storage (GO:0010885)2.18016019
165cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.17766677
166regulation of early endosome to late endosome transport (GO:2000641)2.17165975
167protein hydroxylation (GO:0018126)2.16550279
168protein retention in ER lumen (GO:0006621)2.15464834
169carnitine shuttle (GO:0006853)2.15257652
170cortical actin cytoskeleton organization (GO:0030866)2.14245932
171peptidyl-proline hydroxylation (GO:0019511)2.13996919
172membrane budding (GO:0006900)2.13407491
173positive regulation of adherens junction organization (GO:1903393)2.12721048
174tricarboxylic acid metabolic process (GO:0072350)2.12585115
175establishment of protein localization to Golgi (GO:0072600)2.11535279
176alpha-linolenic acid metabolic process (GO:0036109)2.09146629
177epithelial cell-cell adhesion (GO:0090136)2.09017728
178negative regulation of lipid transport (GO:0032369)2.08794012
179positive regulation of protein deacetylation (GO:0090312)2.07981794
180positive regulation of hormone biosynthetic process (GO:0046886)2.07486837
181adherens junction assembly (GO:0034333)2.06507160
182positive regulation of lipid catabolic process (GO:0050996)2.05720585
183Golgi organization (GO:0007030)2.05655787
184coronary vasculature morphogenesis (GO:0060977)2.05517272
185intracellular lipid transport (GO:0032365)2.05443662
186regulation of glycogen biosynthetic process (GO:0005979)2.05157948
187regulation of glucan biosynthetic process (GO:0010962)2.05157948
188regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.03907488
189retrograde transport, vesicle recycling within Golgi (GO:0000301)2.03700386
190regulation of sequestering of triglyceride (GO:0010889)2.02747184
191positive regulation of blood vessel endothelial cell migration (GO:0043536)2.01709255
192response to endoplasmic reticulum stress (GO:0034976)2.00393810
193negative regulation of cardiac muscle tissue growth (GO:0055022)1.99315121
194negative regulation of heart growth (GO:0061117)1.99315121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.34170685
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16009023
3GBX2_23144817_ChIP-Seq_PC3_Human2.94515869
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.88215973
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70776973
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.67454282
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55768809
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.49298554
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46205120
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40958245
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35452477
12CLOCK_20551151_ChIP-Seq_293T_Human2.31734498
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26238607
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.23649891
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.17227555
16FOXO3_23340844_ChIP-Seq_DLD1_Human2.12200722
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10221391
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.08446914
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.05518846
20PIAS1_25552417_ChIP-Seq_VCAP_Human2.03503928
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89224520
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88718997
23SMAD4_21799915_ChIP-Seq_A2780_Human1.86664349
24ER_23166858_ChIP-Seq_MCF-7_Human1.85099990
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84205660
26ZNF274_21170338_ChIP-Seq_K562_Hela1.83937465
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81464593
28AHR_22903824_ChIP-Seq_MCF-7_Human1.80960631
29P300_19829295_ChIP-Seq_ESCs_Human1.76285210
30TAF15_26573619_Chip-Seq_HEK293_Human1.75726913
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75460060
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74215399
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.73810358
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.72893153
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.72828197
36* TBX20_22080862_ChIP-Seq_HEART_Mouse1.72230252
37* TBX20_22328084_ChIP-Seq_HEART_Mouse1.72230252
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71982496
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.71938573
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70295356
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68346103
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67953354
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67662270
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62533118
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62449274
46AR_25329375_ChIP-Seq_VCAP_Human1.61737864
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60464409
48KDM2B_26808549_Chip-Seq_DND41_Human1.59817739
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58147134
50* STAT3_23295773_ChIP-Seq_U87_Human1.57933814
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56933370
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56629963
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56596973
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56215056
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55916087
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55484046
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55247942
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53469487
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52910830
60BCAT_22108803_ChIP-Seq_LS180_Human1.51959327
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.51856194
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.51632601
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51533258
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49914479
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49895187
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.49088691
67FUS_26573619_Chip-Seq_HEK293_Human1.48634112
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.47799190
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47765270
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.46861181
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45384041
72TP53_16413492_ChIP-PET_HCT116_Human1.44809672
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44207405
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43347877
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.43078522
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.42565768
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.41727523
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41538769
79EWS_26573619_Chip-Seq_HEK293_Human1.41410969
80* TCF4_23295773_ChIP-Seq_U87_Human1.39362694
81* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38950407
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38753422
83VDR_22108803_ChIP-Seq_LS180_Human1.38481543
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38421148
85KDM2B_26808549_Chip-Seq_K562_Human1.38284255
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38034352
87* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37372506
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.37178313
89CDX2_22108803_ChIP-Seq_LS180_Human1.37043925
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36913613
91ZNF263_19887448_ChIP-Seq_K562_Human1.36717407
92TCF7_22412390_ChIP-Seq_EML_Mouse1.36672830
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35905863
94CBP_20019798_ChIP-Seq_JUKART_Human1.34477634
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34477634
96CJUN_26792858_Chip-Seq_BT549_Human1.34474116
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34364021
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34184000
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34057100
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.33756253
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33726385
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33215188
103* TP53_18474530_ChIP-ChIP_U2OS_Human1.33211925
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32906350
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32763727
106P53_22387025_ChIP-Seq_ESCs_Mouse1.32637174
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31166524
108RACK7_27058665_Chip-Seq_MCF-7_Human1.30957031
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30830035
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30547194
111* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27521188
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.27255790
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.25899366
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.25040383
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.24378179
116GATA1_19941826_ChIP-Seq_K562_Human1.24364386
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.24347095
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24046087
119* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23916601
120HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23884764
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22641579
122TCF4_22108803_ChIP-Seq_LS180_Human1.22410292
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20844861
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19808711
125STAT3_18555785_Chip-Seq_ESCs_Mouse1.19060590
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18623376
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.16036572
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.15979061
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15480449
130IGF1R_20145208_ChIP-Seq_DFB_Human1.14486537
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14029525
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13985922
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.13818101
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13443615
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13278024
136P300_18555785_Chip-Seq_ESCs_Mouse1.12659259
137LXR_22292898_ChIP-Seq_THP-1_Human1.12166260
138ATF3_27146783_Chip-Seq_COLON_Human1.11122775
139SOX2_20726797_ChIP-Seq_SW620_Human1.09201543
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09148643
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08994547
142BRD4_25478319_ChIP-Seq_HGPS_Human1.08335792
143SOX2_18555785_Chip-Seq_ESCs_Mouse1.08183323
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08062437
145SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07786738
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07786738
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07385865
148WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07359566
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07270729
150NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07270729
151SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07182773
152GATA1_22025678_ChIP-Seq_K562_Human1.06420008
153LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05933066
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04717325
155WT1_19549856_ChIP-ChIP_CCG9911_Human1.04021953
156RUNX2_22187159_ChIP-Seq_PCA_Human1.03856773
157SOX2_21211035_ChIP-Seq_LN229_Gbm1.03838082
158SMAD4_21741376_ChIP-Seq_EPCs_Human1.03356589
159* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02566633
160RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02490600
161FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01924007
162GATA6_25053715_ChIP-Seq_YYC3_Human1.00572461
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99865704
164NMYC_18555785_Chip-Seq_ESCs_Mouse0.99383291
165STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98826283
166GATA2_19941826_ChIP-Seq_K562_Human0.98663896
167JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97443047
168SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97033664
169* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96827913
170JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96783579
171FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96777054
172SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96656752
173SPI1_23127762_ChIP-Seq_K562_Human0.96652281
174RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96189493
175CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95330748
176CREB1_26743006_Chip-Seq_LNCaP_Human0.94330854
177ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92910936
178VDR_24787735_ChIP-Seq_THP-1_Human0.92416889
179* TP63_23658742_ChIP-Seq_EP156T_Human0.92240291
180SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90852161
181AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90836504
182THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90584071
183FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90493313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.11044210
2MP0008438_abnormal_cutaneous_collagen3.09893333
3MP0005379_endocrine/exocrine_gland_phen3.07889330
4MP0003300_gastrointestinal_ulcer3.01649186
5MP0002877_abnormal_melanocyte_morpholog2.95053798
6MP0003122_maternal_imprinting2.88185975
7MP0004185_abnormal_adipocyte_glucose2.51929339
8MP0005275_abnormal_skin_tensile2.40265775
9MP0005367_renal/urinary_system_phenotyp2.30837551
10MP0000516_abnormal_urinary_system2.30837551
11MP0002876_abnormal_thyroid_physiology2.30714966
12MP0000427_abnormal_hair_cycle2.30060031
13MP0005646_abnormal_pituitary_gland2.21767889
14MP0002163_abnormal_gland_morphology2.20229002
15MP0009780_abnormal_chondrocyte_physiolo2.18896522
16MP0010234_abnormal_vibrissa_follicle2.18709650
17MP0006054_spinal_hemorrhage2.18134159
18MP0003566_abnormal_cell_adhesion2.14991874
19MP0005623_abnormal_meninges_morphology2.14657254
20MP0004130_abnormal_muscle_cell2.11690740
21MP0005076_abnormal_cell_differentiation2.06637953
22MP0010386_abnormal_urinary_bladder2.05721439
23MP0003950_abnormal_plasma_membrane2.04498213
24MP0009046_muscle_twitch2.02949192
25MP0004885_abnormal_endolymph2.02356500
26MP0003787_abnormal_imprinting2.01739844
27MP0000013_abnormal_adipose_tissue1.98963274
28MP0003252_abnormal_bile_duct1.93900580
29MP0010352_gastrointestinal_tract_polyps1.92145973
30MP0002928_abnormal_bile_duct1.82672510
31MP0004272_abnormal_basement_membrane1.80849746
32MP0002837_dystrophic_cardiac_calcinosis1.80316755
33MP0001984_abnormal_olfaction1.79843065
34MP0005666_abnormal_adipose_tissue1.79730752
35MP0003303_peritoneal_inflammation1.77952800
36MP0005257_abnormal_intraocular_pressure1.71252294
37MP0008877_abnormal_DNA_methylation1.70712795
38MP0005375_adipose_tissue_phenotype1.70223072
39MP0003121_genomic_imprinting1.69351933
40MP0006072_abnormal_retinal_apoptosis1.69178148
41MP0000003_abnormal_adipose_tissue1.65195091
42MP0002896_abnormal_bone_mineralization1.61325904
43MP0004270_analgesia1.59932806
44MP0002102_abnormal_ear_morphology1.59177894
45MP0003091_abnormal_cell_migration1.56088189
46MP0000639_abnormal_adrenal_gland1.53672543
47MP0002139_abnormal_hepatobiliary_system1.53595374
48MP0005220_abnormal_exocrine_pancreas1.52867398
49MP0003045_fibrosis1.52712180
50MP0000383_abnormal_hair_follicle1.51893423
51MP0004084_abnormal_cardiac_muscle1.51589823
52MP0009384_cardiac_valve_regurgitation1.51311268
53MP0004087_abnormal_muscle_fiber1.51175185
54MP0005360_urolithiasis1.50310880
55MP0002693_abnormal_pancreas_physiology1.49845809
56MP0003279_aneurysm1.37662323
57MP0000733_abnormal_muscle_development1.37437482
58MP0005551_abnormal_eye_electrophysiolog1.35238675
59MP0000751_myopathy1.34626052
60MP0002060_abnormal_skin_morphology1.33384950
61MP0000538_abnormal_urinary_bladder1.31328491
62MP0001756_abnormal_urination1.30698840
63MP0008961_abnormal_basal_metabolism1.30358277
64MP0010368_abnormal_lymphatic_system1.28354465
65MP0000747_muscle_weakness1.25676984
66MP0003453_abnormal_keratinocyte_physiol1.25133671
67MP0005253_abnormal_eye_physiology1.24004427
68MP0001958_emphysema1.23399044
69MP0008872_abnormal_physiological_respon1.23395663
70MP0002796_impaired_skin_barrier1.22932342
71MP0005645_abnormal_hypothalamus_physiol1.22366985
72MP0003123_paternal_imprinting1.21495020
73MP0001501_abnormal_sleep_pattern1.21459024
74MP0009745_abnormal_behavioral_response1.20450859
75MP0004134_abnormal_chest_morphology1.20260242
76MP0010630_abnormal_cardiac_muscle1.19141205
77MP0005058_abnormal_lysosome_morphology1.18802403
78MP0004036_abnormal_muscle_relaxation1.18397964
79MP0002160_abnormal_reproductive_system1.16341602
80MP0005330_cardiomyopathy1.15750768
81MP0005084_abnormal_gallbladder_morpholo1.14934327
82MP0005248_abnormal_Harderian_gland1.14657986
83MP0001299_abnormal_eye_distance/1.13836249
84MP0004924_abnormal_behavior1.13398875
85MP0005386_behavior/neurological_phenoty1.13398875
86MP0003195_calcinosis1.12833066
87MP0000750_abnormal_muscle_regeneration1.12562971
88MP0000569_abnormal_digit_pigmentation1.12292822
89MP0002734_abnormal_mechanical_nocicepti1.12245464
90MP0001879_abnormal_lymphatic_vessel1.11386920
91MP0005023_abnormal_wound_healing1.09503265
92MP0003283_abnormal_digestive_organ1.09348190
93MP0005503_abnormal_tendon_morphology1.09297511
94MP0005389_reproductive_system_phenotype1.08328988
95MP0004947_skin_inflammation1.08215575
96MP0002909_abnormal_adrenal_gland1.06271425
97MP0001440_abnormal_grooming_behavior1.03907625
98MP0001542_abnormal_bone_strength1.03520077
99MP0002272_abnormal_nervous_system1.03458288
100MP0002064_seizures1.03237008
101MP0000749_muscle_degeneration1.02878855
102MP0002090_abnormal_vision1.02450621
103MP0008775_abnormal_heart_ventricle1.02397285
104MP0002138_abnormal_hepatobiliary_system1.02056474
105MP0004043_abnormal_pH_regulation1.01681703
106MP0002971_abnormal_brown_adipose1.00140781
107MP0002269_muscular_atrophy0.99386792
108MP0003880_abnormal_central_pattern0.99290527
109MP0002972_abnormal_cardiac_muscle0.99094805
110MP0003633_abnormal_nervous_system0.98532451
111MP0002078_abnormal_glucose_homeostasis0.98452344
112MP0002166_altered_tumor_susceptibility0.97054939
113MP0001849_ear_inflammation0.96381183
114MP0001544_abnormal_cardiovascular_syste0.95712211
115MP0005385_cardiovascular_system_phenoty0.95712211
116MP0004510_myositis0.94760467
117MP0001944_abnormal_pancreas_morphology0.94192915
118MP0000767_abnormal_smooth_muscle0.93757184
119MP0002168_other_aberrant_phenotype0.93294926
120MP0005408_hypopigmentation0.92759773
121MP0005365_abnormal_bile_salt0.91938695
122MP0006138_congestive_heart_failure0.91510833
123MP0010678_abnormal_skin_adnexa0.90489640
124MP0000230_abnormal_systemic_arterial0.90092372
125MP0002998_abnormal_bone_remodeling0.89823400
126MP0005620_abnormal_muscle_contractility0.89230991
127MP0004145_abnormal_muscle_electrophysio0.88893631
128MP0005332_abnormal_amino_acid0.88887054
129MP0000759_abnormal_skeletal_muscle0.88054037
130MP0000428_abnormal_craniofacial_morphol0.88030980
131MP0005448_abnormal_energy_balance0.87742799
132MP0002572_abnormal_emotion/affect_behav0.87551190
133MP0003828_pulmonary_edema0.86863100
134MP0001905_abnormal_dopamine_level0.86249488
135MP0005187_abnormal_penis_morphology0.85385599
136MP0001486_abnormal_startle_reflex0.84754041
137MP0002234_abnormal_pharynx_morphology0.83714565
138MP0002106_abnormal_muscle_physiology0.83303178
139MP0003953_abnormal_hormone_level0.83057798
140MP0001666_abnormal_nutrient_absorption0.82542857
141MP0002184_abnormal_innervation0.82341788
142MP0002557_abnormal_social/conspecific_i0.82182642
143MP0004858_abnormal_nervous_system0.81998373
144MP0002295_abnormal_pulmonary_circulatio0.81701006
145MP0001919_abnormal_reproductive_system0.80330469
146MP0000462_abnormal_digestive_system0.80192709
147MP0009643_abnormal_urine_homeostasis0.79647863
148MP0010329_abnormal_lipoprotein_level0.78995225
149MP0003646_muscle_fatigue0.78448487
150MP0002006_tumorigenesis0.78402770
151MP0005167_abnormal_blood-brain_barrier0.78278840
152MP0000631_abnormal_neuroendocrine_gland0.76576748
153MP0004264_abnormal_extraembryonic_tissu0.76511926
154MP0002229_neurodegeneration0.76324023
155MP0001533_abnormal_skeleton_physiology0.75625411
156MP0000647_abnormal_sebaceous_gland0.75011058
157MP0001915_intracranial_hemorrhage0.74946660
158MP0004233_abnormal_muscle_weight0.74934708
159MP0000609_abnormal_liver_physiology0.74761197
160MP0000377_abnormal_hair_follicle0.74553801
161MP0001216_abnormal_epidermal_layer0.74440058
162MP0009840_abnormal_foam_cell0.74048549
163MP0002128_abnormal_blood_circulation0.72711514
164MP0004215_abnormal_myocardial_fiber0.72271336
165MP0002118_abnormal_lipid_homeostasis0.72167305
166MP0000579_abnormal_nail_morphology0.72092322
167MP0003936_abnormal_reproductive_system0.71528510
168MP0001970_abnormal_pain_threshold0.71495418
169MP0002063_abnormal_learning/memory/cond0.70515279
170MP0003635_abnormal_synaptic_transmissio0.69934991
171MP0005409_darkened_coat_color0.69729161
172MP0000613_abnormal_salivary_gland0.68078699
173MP0005595_abnormal_vascular_smooth0.67838686
174MP0005164_abnormal_response_to0.66596096
175MP0004883_abnormal_blood_vessel0.66077205

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)3.59618104
2Protrusio acetabuli (HP:0003179)3.49067756
3Enlarged penis (HP:0000040)3.46120772
4Large for gestational age (HP:0001520)3.44318455
5Abnormal sex determination (HP:0012244)3.38923420
6Sex reversal (HP:0012245)3.38923420
7Premature rupture of membranes (HP:0001788)3.37480551
8Hyporeflexia of lower limbs (HP:0002600)3.19838917
9Arthropathy (HP:0003040)3.19727611
10Testicular neoplasm (HP:0010788)3.13642163
11Hypoglycemic seizures (HP:0002173)3.08929466
12Cerebral aneurysm (HP:0004944)3.06951107
13Papillary thyroid carcinoma (HP:0002895)2.92669069
14Metaphyseal dysplasia (HP:0100255)2.91410539
15Increased connective tissue (HP:0009025)2.90565918
16Shallow orbits (HP:0000586)2.89772944
17Tongue fasciculations (HP:0001308)2.89082695
18Hyperventilation (HP:0002883)2.86109873
19Type 1 muscle fiber predominance (HP:0003803)2.84239657
20Mesomelia (HP:0003027)2.84117791
21Hemiparesis (HP:0001269)2.83602596
22Thyroid carcinoma (HP:0002890)2.80919625
23Mitral valve prolapse (HP:0001634)2.69823642
24Adrenal hypoplasia (HP:0000835)2.68220359
25Broad metatarsal (HP:0001783)2.57155800
26Medial flaring of the eyebrow (HP:0010747)2.56700697
27Delayed gross motor development (HP:0002194)2.55272534
28Abnormality of the renal cortex (HP:0011035)2.55248538
29Right ventricular cardiomyopathy (HP:0011663)2.54796395
30Neoplasm of the adrenal cortex (HP:0100641)2.54744010
31Median cleft lip (HP:0000161)2.53414965
32Epileptiform EEG discharges (HP:0011182)2.50035872
33Aortic aneurysm (HP:0004942)2.49518153
34Dilatation of the ascending aorta (HP:0005111)2.48619653
35Abnormality of the astrocytes (HP:0100707)2.47809454
36Astrocytoma (HP:0009592)2.47809454
37Conjunctival hamartoma (HP:0100780)2.47771797
38EEG with generalized epileptiform discharges (HP:0011198)2.45918048
39Macroorchidism (HP:0000053)2.45644104
40Aneurysm (HP:0002617)2.45380756
41Atrophic scars (HP:0001075)2.44509191
42Furrowed tongue (HP:0000221)2.44174940
43Hypokinesia (HP:0002375)2.40384663
44Lymphangioma (HP:0100764)2.40016857
45Thin bony cortex (HP:0002753)2.39434464
46Exercise-induced muscle cramps (HP:0003710)2.38010369
47Asymmetric septal hypertrophy (HP:0001670)2.37157422
48Mildly elevated creatine phosphokinase (HP:0008180)2.35517721
49Sudden death (HP:0001699)2.34852691
50Ankle contracture (HP:0006466)2.33195089
51Hamartoma of the eye (HP:0010568)2.32553648
52Peritonitis (HP:0002586)2.32366860
53Hypsarrhythmia (HP:0002521)2.30754558
54Exercise-induced myalgia (HP:0003738)2.29877826
55Muscle fibrillation (HP:0010546)2.29797927
56Aortic dissection (HP:0002647)2.29515277
57Difficulty running (HP:0009046)2.29193371
58Asymmetry of the thorax (HP:0001555)2.27855212
59Achilles tendon contracture (HP:0001771)2.26570989
60Hypoplastic ischia (HP:0003175)2.25180249
61Myocardial infarction (HP:0001658)2.24870482
62Hematochezia (HP:0002573)2.24555097
63Pancreatic cysts (HP:0001737)2.23221446
64Spinal rigidity (HP:0003306)2.22970746
65Symptomatic seizures (HP:0011145)2.21846191
66Aqueductal stenosis (HP:0002410)2.21093682
67Abnormality of the Achilles tendon (HP:0005109)2.20987181
68Ketoacidosis (HP:0001993)2.20972946
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18915942
70Gait imbalance (HP:0002141)2.18894303
71Widely spaced teeth (HP:0000687)2.18867461
72Increased circulating renin level (HP:0000848)2.14539449
73Congenital primary aphakia (HP:0007707)2.14477671
74Sensory axonal neuropathy (HP:0003390)2.12999026
75Difficulty climbing stairs (HP:0003551)2.12688509
76Neoplasm of the thyroid gland (HP:0100031)2.12604260
77Subacute progressive viral hepatitis (HP:0006572)2.11046120
78Hypoglycemic coma (HP:0001325)2.10930793
79Ventricular tachycardia (HP:0004756)2.10598487
80Hyperglycemia (HP:0003074)2.10141047
81Muscle fiber splitting (HP:0003555)2.09617114
82Long toe (HP:0010511)2.09191679
83Myoglobinuria (HP:0002913)2.08804099
84Increased variability in muscle fiber diameter (HP:0003557)2.07026187
85Ependymoma (HP:0002888)2.06938175
86Increased cerebral lipofuscin (HP:0011813)2.06671612
87Pancreatic fibrosis (HP:0100732)2.06336614
88Genu recurvatum (HP:0002816)2.05150420
89Buphthalmos (HP:0000557)2.04086622
90Curly hair (HP:0002212)2.03047790
91Focal seizures (HP:0007359)2.02118371
92Abnormality of the frontal sinuses (HP:0002687)2.01891978
93Bronchomalacia (HP:0002780)2.01384331
94Abnormality of the nasal septum (HP:0000419)2.00239910
95Abnormal biliary tract morphology (HP:0012440)1.99956848
96Frequent falls (HP:0002359)1.98957749
97Tubular atrophy (HP:0000092)1.97577403
98Gaze-evoked nystagmus (HP:0000640)1.97172817
99Febrile seizures (HP:0002373)1.97021396
100Diminished movement (HP:0002374)1.96944818
101Rectal prolapse (HP:0002035)1.96112189
102Abnormality of the ischium (HP:0003174)1.96072748
103Cervical subluxation (HP:0003308)1.95744448
104Hyperinsulinemic hypoglycemia (HP:0000825)1.95174355
105Deep venous thrombosis (HP:0002625)1.94914981
106Congenital sensorineural hearing impairment (HP:0008527)1.94774361
107Exostoses (HP:0100777)1.94773969
108Meningioma (HP:0002858)1.93712034
109Turricephaly (HP:0000262)1.93631539
110Skin nodule (HP:0200036)1.93546752
111Volvulus (HP:0002580)1.93440144
112Tubulointerstitial nephritis (HP:0001970)1.93348215
113Menstrual irregularities (HP:0000858)1.93311245
114Thyroiditis (HP:0100646)1.93047415
115Biliary tract neoplasm (HP:0100574)1.92834059
116Aplasia/hypoplasia of the uterus (HP:0008684)1.92078298
117Genital tract atresia (HP:0001827)1.91769763
118Glioma (HP:0009733)1.90746605
119Nephrogenic diabetes insipidus (HP:0009806)1.89870266
120Renal cortical cysts (HP:0000803)1.88235574
121Vacuolated lymphocytes (HP:0001922)1.87824061
122Bladder diverticulum (HP:0000015)1.87619757
123Scapular winging (HP:0003691)1.87119690
124Hypomagnesemia (HP:0002917)1.86940700
125Abnormality of the left ventricular outflow tract (HP:0011103)1.86902183
126Subaortic stenosis (HP:0001682)1.86902183
127EMG: myopathic abnormalities (HP:0003458)1.85240582
128Hyperextensible skin (HP:0000974)1.84359972
129Abnormality of skeletal muscle fiber size (HP:0012084)1.84264962
130Abnormality of the renal medulla (HP:0100957)1.82855032
131Fragile skin (HP:0001030)1.82691748
132Bone cyst (HP:0012062)1.82671700
133Protuberant abdomen (HP:0001538)1.82525522
134Distal upper limb amyotrophy (HP:0007149)1.81085170
135Upper limb amyotrophy (HP:0009129)1.81085170
136Mucopolysacchariduria (HP:0008155)1.80869520
137Urinary glycosaminoglycan excretion (HP:0003541)1.80869520
138Breast carcinoma (HP:0003002)1.80607057
139Absent speech (HP:0001344)1.79310882
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79049783
141Goiter (HP:0000853)1.78420416
142Striae distensae (HP:0001065)1.78318833
143Abnormal drinking behavior (HP:0030082)1.78269184
144Polydipsia (HP:0001959)1.78269184
145Angiofibromas (HP:0010615)1.78098259
146Adenoma sebaceum (HP:0009720)1.78098259
147Overgrowth (HP:0001548)1.77686670
148Congenital hepatic fibrosis (HP:0002612)1.77679279
149True hermaphroditism (HP:0010459)1.76772987
150Bundle branch block (HP:0011710)1.76324767
151Mitral stenosis (HP:0001718)1.75239125
152Osteolytic defects of the hand bones (HP:0009699)1.75099357
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.75099357
154Xanthomatosis (HP:0000991)1.74965167
155Back pain (HP:0003418)1.74326075
156Muscular hypotonia of the trunk (HP:0008936)1.74210586
157Dysostosis multiplex (HP:0000943)1.73556606
158Calf muscle hypertrophy (HP:0008981)1.73494442
159Short foot (HP:0001773)1.73211092
160Keratoconus (HP:0000563)1.73187848
161Increased corneal curvature (HP:0100692)1.73187848
162Rhabdomyosarcoma (HP:0002859)1.73182384
163Postaxial hand polydactyly (HP:0001162)1.73133125
164Wide anterior fontanel (HP:0000260)1.71494055
165Abnormality of the calf musculature (HP:0001430)1.70968237
166Downturned corners of mouth (HP:0002714)1.70934378
167Postural tremor (HP:0002174)1.70784315
168Decreased central vision (HP:0007663)1.69671125
169Azoospermia (HP:0000027)1.69635295
170Poor coordination (HP:0002370)1.68732705
171Anxiety (HP:0000739)1.68547708
172Congenital glaucoma (HP:0001087)1.67712289
173Insulin-resistant diabetes mellitus (HP:0000831)1.67641474
174Round ear (HP:0100830)1.67092924
175Abnormality of vitamin B metabolism (HP:0004340)1.66404650
176Blue sclerae (HP:0000592)1.66352460
177Nephronophthisis (HP:0000090)1.65113711
178Flat acetabular roof (HP:0003180)1.63617868
179Spondylolisthesis (HP:0003302)1.62992583
180Limb-girdle muscle atrophy (HP:0003797)1.61254620
181Milia (HP:0001056)1.61180205
182Vascular tortuosity (HP:0004948)1.61000627
183Increased neuronal autofluorescent lipopigment (HP:0002074)1.58945433
184Ketosis (HP:0001946)1.58397533
185Visceral angiomatosis (HP:0100761)1.58118840
186Disproportionate tall stature (HP:0001519)1.57962225
187Hypoalphalipoproteinemia (HP:0003233)1.57425699
188Abnormality of mucopolysaccharide metabolism (HP:0011020)1.56938606
189Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56938606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.17601355
2PKN23.22150693
3MST42.79257384
4TTN2.74750375
5RIPK12.56338828
6AKT32.35596854
7LATS12.35467354
8ERN12.33576068
9PDGFRA2.23990017
10CASK2.23731858
11BMPR1B2.14376160
12PTK62.13560668
13ACVR1B2.09348508
14ERBB32.04951568
15DMPK2.01290645
16FES1.94094724
17MAP3K101.93161991
18PLK21.85261999
19SIK11.85201575
20MAP3K21.82530647
21MAP3K121.75858017
22EPHB11.72639167
23TRIM281.71962659
24LRRK21.69718259
25MAP4K21.67154775
26PRKCE1.61177182
27PRKD31.59982973
28WNK31.59785180
29STK38L1.59321341
30RET1.53432925
31EIF2AK31.52096888
32FLT31.51120833
33FGFR41.48930079
34STK391.48865039
35KSR21.44551921
36MAP3K41.43682651
37EPHA31.41000694
38DDR21.34804595
39WNK41.34579171
40PTK21.31631997
41FRK1.30392204
42GRK11.29665411
43PDGFRB1.28921749
44HIPK21.25140678
45NTRK31.24148419
46CAMK1G1.22286010
47STK31.21660135
48STK101.21154479
49FGFR31.21056157
50TAOK31.19785262
51JAK11.18972694
52NTRK11.16351880
53FER1.15738409
54BMPR21.13450761
55PAK31.09417150
56TRPM71.07087988
57NUAK11.04441075
58NEK91.03786126
59CSNK1G21.03411683
60CAMK1D1.01907651
61PRKD11.01638412
62LATS21.01127351
63PRKCH1.00525136
64SGK21.00013015
65WNK10.98023982
66TNIK0.97952266
67MET0.97872515
68MARK10.97688390
69TAOK10.96233191
70TBK10.92426482
71IRAK10.92067778
72MAP3K10.90900305
73MAP3K70.90701089
74TYRO30.88558725
75FGFR20.87878126
76TYK20.87511543
77BMX0.87507356
78CDK60.86793896
79CSNK1G10.86363336
80EEF2K0.85619679
81DYRK1B0.84204376
82ADRBK20.83955352
83PAK20.83185565
84MAPK130.83007638
85MTOR0.82202128
86PNCK0.82152889
87PDK40.80739369
88PDK30.80739369
89CSNK1G30.79737547
90JAK30.79700943
91ILK0.78057223
92EIF2AK10.77699516
93YES10.76917312
94CAMKK10.76191046
95MAP3K30.75595739
96BCR0.74640232
97NLK0.73553087
98JAK20.73358929
99ROCK10.72962725
100MAP3K50.72556157
101INSRR0.72187805
102EPHA20.70219133
103CAMK2D0.68373025
104PHKG10.68273731
105PHKG20.68273731
106LMTK20.67721310
107TAF10.67562097
108PAK60.67357078
109PRKD20.66421234
110RPS6KA40.65586599
111MKNK20.64507473
112TGFBR20.63087278
113STK380.63048443
114OXSR10.62354700
115MARK20.61061536
116MYLK0.60990492
117STK240.60666827
118ALK0.60256138
119EPHB20.60187536
120MAP2K10.58452214
121PDPK10.58112233
122TGFBR10.57584495
123EPHA40.57369490
124SGK30.56892168
125GSK3A0.55156416
126TESK10.54847151
127PRKCG0.54785622
128MAP2K70.54645154
129MUSK0.53546104
130SCYL20.52647644
131IRAK20.51615396
132ADRBK10.51268064
133CAMK10.50410602
134PIK3CA0.48938276
135CSNK1A1L0.48664162
136PLK30.47950583
137DAPK20.47917862
138PDK10.47681763
139PTK2B0.47573793
140PIK3CG0.46665189
141CAMK2A0.46661581
142FGFR10.46623475
143BRD40.46102039
144PRKCI0.45827970
145MAP2K30.45674216
146CAMKK20.45300735
147SGK4940.44678867
148SGK2230.44678867
149NEK60.44128288
150MINK10.43515503
151CHUK0.43154947
152CDK120.43061160
153MELK0.42961447
154PINK10.42935521
155SIK30.42839145
156CSK0.42456503
157PRKAA10.42032124
158MAPKAPK30.41989232
159PRKCQ0.41683746
160ROCK20.41644371
161CSNK1A10.38964927
162MAP3K90.38292959
163MST1R0.37562445
164PRKAA20.37359654
165EGFR0.36985275
166PRKCZ0.35514121
167PRKG20.35247391
168LIMK10.35015183
169STK110.33812175
170GRK50.33620689
171EIF2AK20.33339038

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.80673304
2Protein export_Homo sapiens_hsa030602.79787062
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61213869
4Nitrogen metabolism_Homo sapiens_hsa009102.48630802
5Butanoate metabolism_Homo sapiens_hsa006502.02675969
6Circadian rhythm_Homo sapiens_hsa047102.02169218
7Collecting duct acid secretion_Homo sapiens_hsa049662.00728394
8Synaptic vesicle cycle_Homo sapiens_hsa047211.82588632
9Focal adhesion_Homo sapiens_hsa045101.50232338
10Insulin resistance_Homo sapiens_hsa049311.50147403
11Fatty acid degradation_Homo sapiens_hsa000711.46773166
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45916695
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36251530
14Vibrio cholerae infection_Homo sapiens_hsa051101.35875366
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34886610
16Proteoglycans in cancer_Homo sapiens_hsa052051.33987445
17ECM-receptor interaction_Homo sapiens_hsa045121.33782940
18Type II diabetes mellitus_Homo sapiens_hsa049301.31037746
19Chronic myeloid leukemia_Homo sapiens_hsa052201.30632119
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.30021542
21Sphingolipid metabolism_Homo sapiens_hsa006001.29990983
22Regulation of autophagy_Homo sapiens_hsa041401.29615125
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.27874370
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26424406
25Phototransduction_Homo sapiens_hsa047441.24737167
26Dopaminergic synapse_Homo sapiens_hsa047281.24329809
27Lysine degradation_Homo sapiens_hsa003101.21398455
28Amphetamine addiction_Homo sapiens_hsa050311.20526038
29Dilated cardiomyopathy_Homo sapiens_hsa054141.20315960
30Dorso-ventral axis formation_Homo sapiens_hsa043201.20307503
31Circadian entrainment_Homo sapiens_hsa047131.19920493
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18877521
33Adherens junction_Homo sapiens_hsa045201.18761911
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16192831
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15656013
36Cocaine addiction_Homo sapiens_hsa050301.15473012
37GABAergic synapse_Homo sapiens_hsa047271.15146010
38Amoebiasis_Homo sapiens_hsa051461.13260007
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13220293
40PPAR signaling pathway_Homo sapiens_hsa033201.11580064
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11043124
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10769535
43mTOR signaling pathway_Homo sapiens_hsa041501.09288719
44Arginine biosynthesis_Homo sapiens_hsa002201.06848532
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06222515
46Glioma_Homo sapiens_hsa052141.05644830
47Renal cell carcinoma_Homo sapiens_hsa052111.05597458
48Pancreatic cancer_Homo sapiens_hsa052121.05594950
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04190218
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03507388
51Protein digestion and absorption_Homo sapiens_hsa049741.02830370
52VEGF signaling pathway_Homo sapiens_hsa043701.02503151
53Bladder cancer_Homo sapiens_hsa052191.01241647
54Ether lipid metabolism_Homo sapiens_hsa005651.01219306
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00641258
56Endometrial cancer_Homo sapiens_hsa052131.00450726
57Viral myocarditis_Homo sapiens_hsa054160.99129397
58Long-term depression_Homo sapiens_hsa047300.98960465
59Insulin signaling pathway_Homo sapiens_hsa049100.97779002
60Toxoplasmosis_Homo sapiens_hsa051450.97712554
61Small cell lung cancer_Homo sapiens_hsa052220.96036621
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95724326
63Sulfur metabolism_Homo sapiens_hsa009200.94819116
64Glutamatergic synapse_Homo sapiens_hsa047240.92860902
65AMPK signaling pathway_Homo sapiens_hsa041520.92534212
66Fatty acid metabolism_Homo sapiens_hsa012120.91324043
67Ovarian steroidogenesis_Homo sapiens_hsa049130.90810878
68Mineral absorption_Homo sapiens_hsa049780.90750351
69Estrogen signaling pathway_Homo sapiens_hsa049150.90531338
70Prolactin signaling pathway_Homo sapiens_hsa049170.90065266
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.87682594
72Caffeine metabolism_Homo sapiens_hsa002320.86798384
73Salivary secretion_Homo sapiens_hsa049700.86546334
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86438689
75Bile secretion_Homo sapiens_hsa049760.86326694
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86228233
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85507952
78Gastric acid secretion_Homo sapiens_hsa049710.85149834
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.85139178
80ABC transporters_Homo sapiens_hsa020100.85099239
81Platelet activation_Homo sapiens_hsa046110.84965518
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84170450
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84030671
84Fatty acid elongation_Homo sapiens_hsa000620.83992475
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82269452
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81526379
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80847786
88Osteoclast differentiation_Homo sapiens_hsa043800.80845339
89Melanoma_Homo sapiens_hsa052180.80777717
90Propanoate metabolism_Homo sapiens_hsa006400.80680819
91Inositol phosphate metabolism_Homo sapiens_hsa005620.80517328
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80180407
93Serotonergic synapse_Homo sapiens_hsa047260.78807886
94Fat digestion and absorption_Homo sapiens_hsa049750.78165620
95Glucagon signaling pathway_Homo sapiens_hsa049220.78150291
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.76418190
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75605440
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74490545
99Nicotine addiction_Homo sapiens_hsa050330.74431759
100Acute myeloid leukemia_Homo sapiens_hsa052210.73578949
101Lysosome_Homo sapiens_hsa041420.73510086
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73409786
103Non-small cell lung cancer_Homo sapiens_hsa052230.73137523
104Tryptophan metabolism_Homo sapiens_hsa003800.73015012
105Selenocompound metabolism_Homo sapiens_hsa004500.72943750
106Prostate cancer_Homo sapiens_hsa052150.72741545
107TGF-beta signaling pathway_Homo sapiens_hsa043500.71396344
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70686418
109Hedgehog signaling pathway_Homo sapiens_hsa043400.70521888
110beta-Alanine metabolism_Homo sapiens_hsa004100.70483579
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.69973390
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68978793
113Starch and sucrose metabolism_Homo sapiens_hsa005000.68363137
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.68273907
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67958517
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67487878
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67126778
118MicroRNAs in cancer_Homo sapiens_hsa052060.67111347
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.65928321
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65415016
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63309583
122Steroid biosynthesis_Homo sapiens_hsa001000.62569205
123Renin secretion_Homo sapiens_hsa049240.62329382
124Insulin secretion_Homo sapiens_hsa049110.61284554
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60667707
126Basal transcription factors_Homo sapiens_hsa030220.60394121
127Tight junction_Homo sapiens_hsa045300.60385048
128GnRH signaling pathway_Homo sapiens_hsa049120.59788957
129* Endocytosis_Homo sapiens_hsa041440.59742294
130Retinol metabolism_Homo sapiens_hsa008300.59564165
131Oxytocin signaling pathway_Homo sapiens_hsa049210.58922649
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.58735867
133Peroxisome_Homo sapiens_hsa041460.58587029
134Morphine addiction_Homo sapiens_hsa050320.58529063
135Thyroid hormone synthesis_Homo sapiens_hsa049180.57911727
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.57735717
137TNF signaling pathway_Homo sapiens_hsa046680.57579267
138Chemical carcinogenesis_Homo sapiens_hsa052040.57446602
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56871647
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.56555705
141cAMP signaling pathway_Homo sapiens_hsa040240.56065604
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56003809
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55718736
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53140192
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53033395
146N-Glycan biosynthesis_Homo sapiens_hsa005100.52968852
147Pancreatic secretion_Homo sapiens_hsa049720.52442773
148Hippo signaling pathway_Homo sapiens_hsa043900.52295291
149Hepatitis C_Homo sapiens_hsa051600.52270521
150FoxO signaling pathway_Homo sapiens_hsa040680.51920441
151B cell receptor signaling pathway_Homo sapiens_hsa046620.51733733
152Fatty acid biosynthesis_Homo sapiens_hsa000610.50721243
153Cholinergic synapse_Homo sapiens_hsa047250.50402611
154Colorectal cancer_Homo sapiens_hsa052100.49283120
155Rap1 signaling pathway_Homo sapiens_hsa040150.48713032
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45440510
157Ras signaling pathway_Homo sapiens_hsa040140.45292135
158Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42215466
159Linoleic acid metabolism_Homo sapiens_hsa005910.42160576
160Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41615579
161Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41501123
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40722946

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