RAB23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)4.02320816
2chondrocyte proliferation (GO:0035988)3.97721713
3cell adhesion mediated by integrin (GO:0033627)3.94483171
4bone trabecula formation (GO:0060346)3.80474721
5paraxial mesoderm development (GO:0048339)3.68668636
6extracellular matrix assembly (GO:0085029)3.52992335
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.51590711
8polarized epithelial cell differentiation (GO:0030859)3.48594883
9protein heterotrimerization (GO:0070208)3.46677563
10cell migration involved in sprouting angiogenesis (GO:0002042)3.39399620
11cell migration involved in heart development (GO:0060973)3.34669462
12sequestering of extracellular ligand from receptor (GO:0035581)3.30496474
13collagen fibril organization (GO:0030199)3.29296341
14retina vasculature morphogenesis in camera-type eye (GO:0061299)3.28124197
15substrate-dependent cell migration (GO:0006929)3.26160336
16regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.19868784
17dermatan sulfate biosynthetic process (GO:0030208)3.18529031
18type B pancreatic cell proliferation (GO:0044342)3.17059919
19hippo signaling (GO:0035329)3.16777794
20anterior/posterior axis specification, embryo (GO:0008595)3.16163516
21regulation of centriole replication (GO:0046599)3.12283857
22collagen metabolic process (GO:0032963)3.11476014
23mesenchymal-epithelial cell signaling (GO:0060638)3.10286384
24protein retention in ER lumen (GO:0006621)3.06268504
25lateral sprouting from an epithelium (GO:0060601)3.03539353
26COPI coating of Golgi vesicle (GO:0048205)3.02779617
27Golgi transport vesicle coating (GO:0048200)3.02779617
28planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98992756
29substrate adhesion-dependent cell spreading (GO:0034446)2.98587605
30* craniofacial suture morphogenesis (GO:0097094)2.95829222
31collagen catabolic process (GO:0030574)2.94417691
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.93624713
33multicellular organismal macromolecule metabolic process (GO:0044259)2.90571528
34endothelial cell morphogenesis (GO:0001886)2.90563507
35COPII vesicle coating (GO:0048208)2.88496125
36cell-substrate junction assembly (GO:0007044)2.86675457
37outer ear morphogenesis (GO:0042473)2.86112707
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83785015
39central nervous system myelination (GO:0022010)2.78764739
40axon ensheathment in central nervous system (GO:0032291)2.78764739
41dermatan sulfate metabolic process (GO:0030205)2.77042829
42negative regulation of BMP signaling pathway (GO:0030514)2.76773381
43embryonic body morphogenesis (GO:0010172)2.74507083
44body morphogenesis (GO:0010171)2.74256901
45multicellular organismal metabolic process (GO:0044236)2.72379939
46protein localization to cell surface (GO:0034394)2.72167162
47fibril organization (GO:0097435)2.69872706
48negative regulation of catenin import into nucleus (GO:0035414)2.68327203
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67998563
50mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.67896402
51cochlea morphogenesis (GO:0090103)2.66162647
52extracellular matrix disassembly (GO:0022617)2.65582605
53regulation of hippo signaling (GO:0035330)2.65219966
54synaptic vesicle maturation (GO:0016188)2.64923587
55negative regulation of axon extension involved in axon guidance (GO:0048843)2.64576523
56smooth muscle tissue development (GO:0048745)2.63515872
57multicellular organismal catabolic process (GO:0044243)2.63210449
58keratan sulfate catabolic process (GO:0042340)2.62098391
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61805486
60G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.61440476
61extracellular regulation of signal transduction (GO:1900115)2.61161394
62extracellular negative regulation of signal transduction (GO:1900116)2.61161394
63heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.60151112
64regulation of mitotic spindle organization (GO:0060236)2.60056461
65cranial suture morphogenesis (GO:0060363)2.59838332
66regulation of transforming growth factor beta2 production (GO:0032909)2.58031251
67histone arginine methylation (GO:0034969)2.57847572
68negative regulation of DNA repair (GO:0045738)2.57841869
69heterochromatin organization (GO:0070828)2.56696334
70negative regulation of chondrocyte differentiation (GO:0032331)2.55887251
71notochord development (GO:0030903)2.55764718
72hemidesmosome assembly (GO:0031581)2.54719807
73mesodermal cell differentiation (GO:0048333)2.53838829
74adherens junction assembly (GO:0034333)2.53815760
75Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.53698251
76vascular endothelial growth factor signaling pathway (GO:0038084)2.53500772
77cellular response to vitamin (GO:0071295)2.52463967
78regulation of gene silencing by RNA (GO:0060966)2.51951875
79regulation of posttranscriptional gene silencing (GO:0060147)2.51951875
80regulation of gene silencing by miRNA (GO:0060964)2.51951875
81extracellular matrix organization (GO:0030198)2.51887094
82extracellular structure organization (GO:0043062)2.51028789
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50062077
84regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50051387
85muscle cell migration (GO:0014812)2.49871021
86cell-substrate adherens junction assembly (GO:0007045)2.48938262
87focal adhesion assembly (GO:0048041)2.48938262
88nuclear pore complex assembly (GO:0051292)2.48474416
89establishment of tissue polarity (GO:0007164)2.48197298
90establishment of planar polarity (GO:0001736)2.48197298
91positive regulation of blood vessel endothelial cell migration (GO:0043536)2.46675200
92regulation of establishment of planar polarity (GO:0090175)2.46410692
93ventricular cardiac muscle cell development (GO:0055015)2.45739862
94embryonic cranial skeleton morphogenesis (GO:0048701)2.45358304
95artery development (GO:0060840)2.44861704
96regulation of chondrocyte differentiation (GO:0032330)2.44656929
97nuclear pore organization (GO:0006999)2.44496460
98mitotic cytokinesis (GO:0000281)2.44227008
99metanephric mesenchyme development (GO:0072075)2.42979764
100positive regulation of SMAD protein import into nucleus (GO:0060391)2.42208437
101positive regulation of fibroblast migration (GO:0010763)2.41819726
102cellular response to vitamin D (GO:0071305)2.41052427
103dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.40434142
104glomerular basement membrane development (GO:0032836)2.40368279
105mitotic metaphase plate congression (GO:0007080)2.39436458
106positive regulation of osteoblast proliferation (GO:0033690)2.39164633
107axonal fasciculation (GO:0007413)2.38969418
108regulation of osteoblast proliferation (GO:0033688)2.38625973
109negative regulation of osteoblast proliferation (GO:0033689)2.37295414
110protein hydroxylation (GO:0018126)2.36990114
111negative regulation of cartilage development (GO:0061037)2.36967231
112peptidyl-arginine omega-N-methylation (GO:0035247)2.36451039
113UDP-N-acetylglucosamine metabolic process (GO:0006047)2.36265275
114camera-type eye morphogenesis (GO:0048593)2.35790415
115peptidyl-arginine N-methylation (GO:0035246)2.35029274
116peptidyl-arginine methylation (GO:0018216)2.35029274
117regulation of plasminogen activation (GO:0010755)2.34907466
118basement membrane organization (GO:0071711)2.34212250
119chondrocyte development (GO:0002063)2.33957060
120regulation of integrin-mediated signaling pathway (GO:2001044)2.33592896
121cerebellar granule cell differentiation (GO:0021707)2.32913437
122cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.32699978
123regulation of SMAD protein import into nucleus (GO:0060390)2.32306006
124regulation of axon extension involved in axon guidance (GO:0048841)2.31919084
125vesicle coating (GO:0006901)2.31075798
126neuron projection extension involved in neuron projection guidance (GO:1902284)2.30544214
127axon extension involved in axon guidance (GO:0048846)2.30544214
128negative regulation of embryonic development (GO:0045992)2.30236102
129endodermal cell differentiation (GO:0035987)2.29119846
130pre-miRNA processing (GO:0031054)2.26802127
131lung-associated mesenchyme development (GO:0060484)2.25670810
132apical protein localization (GO:0045176)2.25345552
133inner ear receptor cell development (GO:0060119)2.23787411
134positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.23444113
135kidney mesenchyme development (GO:0072074)2.22940569
136regulation of short-term neuronal synaptic plasticity (GO:0048172)2.22451236
137cytoskeleton-dependent cytokinesis (GO:0061640)2.21305162
138mesenchyme development (GO:0060485)2.21085885
139regulation of spindle organization (GO:0090224)2.20891958
140regulation of catenin import into nucleus (GO:0035412)2.20146260
141wound healing, spreading of epidermal cells (GO:0035313)2.19690096
142convergent extension (GO:0060026)2.18882044
143neuron recognition (GO:0008038)2.18142143
144regulation of centrosome cycle (GO:0046605)2.17281875
145peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.15926190
146pituitary gland development (GO:0021983)2.15917633
147establishment of apical/basal cell polarity (GO:0035089)2.14631710
148non-canonical Wnt signaling pathway (GO:0035567)2.14509446
149lymphangiogenesis (GO:0001946)2.13988116
150endocardial cushion development (GO:0003197)2.13212139
151ectodermal placode formation (GO:0060788)2.12239210
152extracellular fibril organization (GO:0043206)2.11440945
153negative regulation of organelle assembly (GO:1902116)2.10897123
154establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.09943833
155proximal/distal pattern formation (GO:0009954)2.08909802
156positive regulation of synapse maturation (GO:0090129)2.08779376
157mesenchymal cell proliferation (GO:0010463)2.07273720
158mesenchymal to epithelial transition (GO:0060231)2.06863059
159short-term memory (GO:0007614)2.06038336
160synaptic vesicle docking involved in exocytosis (GO:0016081)2.05358808
161regulation of centrosome duplication (GO:0010824)2.04820194
162protein polyglutamylation (GO:0018095)2.04727955
163sensory perception of smell (GO:0007608)2.04727803
164spindle assembly involved in mitosis (GO:0090307)2.04542630
165regulation of cellular senescence (GO:2000772)2.04163189
166regulation of activin receptor signaling pathway (GO:0032925)2.03777548
167epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.03202221
168DNA replication-dependent nucleosome assembly (GO:0006335)2.01160264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.97069851
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.71248360
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.60735813
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53816105
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39801063
6E2F7_22180533_ChIP-Seq_HELA_Human2.37607752
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.36671979
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30380404
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29728099
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24521324
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24521324
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24521324
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21293041
14* CJUN_26792858_Chip-Seq_BT549_Human2.19744507
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07864010
16SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.06479478
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03126816
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96124754
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94790813
20CLOCK_20551151_ChIP-Seq_293T_Human1.93875993
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.93041773
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92915509
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91359875
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.87285514
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.86754633
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86349016
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.86221186
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.86221186
29GBX2_23144817_ChIP-Seq_PC3_Human1.83553325
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.76210646
31* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72191164
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71465647
33* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70601729
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70207802
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68104366
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68104366
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66449864
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65158374
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63326578
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.62160713
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61086906
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60532728
43ZNF274_21170338_ChIP-Seq_K562_Hela1.59729947
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.59715630
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.57890581
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54966304
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54832905
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54828611
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.54545150
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49767422
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47724785
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47483152
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47107147
54FUS_26573619_Chip-Seq_HEK293_Human1.46178440
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44505863
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43220298
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42444327
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42090779
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.42083940
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.41685946
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41477955
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41367355
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40397249
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39042212
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36717503
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36717503
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36421086
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.35964377
69* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34288201
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.32918453
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32914243
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31100273
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31029678
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27822673
75* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22971298
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22913378
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22530769
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22008280
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21927798
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20797821
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20751626
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20695716
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20544299
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.20328307
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20011229
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19879428
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17875374
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16954784
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16788826
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16079512
91BRD4_25478319_ChIP-Seq_HGPS_Human1.16024022
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15448534
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15032273
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15008657
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14442137
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.13296233
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13127107
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12928909
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12153770
100* RING1B_27294783_Chip-Seq_ESCs_Mouse1.11694608
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.11173349
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11011855
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10890023
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10488677
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.10186224
106MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08213641
107* RNF2_27304074_Chip-Seq_NSC_Mouse1.08032632
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07859799
109SOX17_20123909_ChIP-Seq_XEN_Mouse1.07064686
110* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06686422
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06466143
112EWS_26573619_Chip-Seq_HEK293_Human1.05862060
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04206017
114TP53_16413492_ChIP-PET_HCT116_Human1.03110019
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02691016
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02679148
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02196011
118* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01799162
119SOX9_26525672_Chip-Seq_HEART_Mouse1.01694294
120* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01635037
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01212853
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00508077
123TP53_18474530_ChIP-ChIP_U2OS_Human1.00488441
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00387408
125AR_21572438_ChIP-Seq_LNCaP_Human1.00277295
126SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99850817
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.99613237
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99458878
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99086737
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98968235
131POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98400236
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98393297
133SMAD4_21799915_ChIP-Seq_A2780_Human0.96315840
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95938110
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95668953
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95368977
137AR_21909140_ChIP-Seq_LNCAP_Human0.94624349
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93517301
139NANOG_16153702_ChIP-ChIP_HESCs_Human0.93090103
140GATA1_26923725_Chip-Seq_HPCs_Mouse0.92683811
141E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92658435
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92518212
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90618384
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90607981
145GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88970164
146SA1_22415368_ChIP-Seq_MEFs_Mouse0.88796480
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88186326
148EOMES_21245162_ChIP-Seq_HESCs_Human0.87943691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.20178158
2MP0005503_abnormal_tendon_morphology3.35787282
3MP0005623_abnormal_meninges_morphology3.20502088
4MP0010030_abnormal_orbit_morphology2.40643542
5MP0003566_abnormal_cell_adhesion2.37576401
6MP0005275_abnormal_skin_tensile2.21485635
7MP0009250_abnormal_appendicular_skeleto2.13525114
8MP0002653_abnormal_ependyma_morphology2.13300256
9MP0003705_abnormal_hypodermis_morpholog2.09818498
10MP0003123_paternal_imprinting2.08250086
11MP0006054_spinal_hemorrhage2.07144420
12MP0003385_abnormal_body_wall2.06191863
13MP0004272_abnormal_basement_membrane1.86847812
14MP0001542_abnormal_bone_strength1.78376314
15MP0004859_abnormal_synaptic_plasticity1.75246681
16MP0009053_abnormal_anal_canal1.75049201
17MP0003942_abnormal_urinary_system1.70939005
18MP0003122_maternal_imprinting1.70915737
19MP0005508_abnormal_skeleton_morphology1.69816873
20MP0000751_myopathy1.68779948
21* MP0003937_abnormal_limbs/digits/tail_de1.67975604
22MP0003755_abnormal_palate_morphology1.64199824
23MP0000767_abnormal_smooth_muscle1.62201346
24MP0001299_abnormal_eye_distance/1.58182716
25MP0003279_aneurysm1.57959406
26MP0009780_abnormal_chondrocyte_physiolo1.56547491
27* MP0002060_abnormal_skin_morphology1.56360002
28MP0002249_abnormal_larynx_morphology1.55671551
29MP0000534_abnormal_ureter_morphology1.53483487
30MP0001958_emphysema1.52096570
31MP0005171_absent_coat_pigmentation1.52074524
32MP0000013_abnormal_adipose_tissue1.50668322
33MP0003283_abnormal_digestive_organ1.50438954
34MP0003136_yellow_coat_color1.48487974
35MP0000778_abnormal_nervous_system1.48418295
36MP0003941_abnormal_skin_development1.46938521
37MP0005023_abnormal_wound_healing1.45807141
38MP0000049_abnormal_middle_ear1.42283011
39MP0000428_abnormal_craniofacial_morphol1.41467812
40MP0004133_heterotaxia1.40842755
41MP0003121_genomic_imprinting1.40693674
42MP0002932_abnormal_joint_morphology1.39777423
43MP0005257_abnormal_intraocular_pressure1.36917834
44MP0002233_abnormal_nose_morphology1.32288262
45MP0002938_white_spotting1.32119497
46* MP0001293_anophthalmia1.30990925
47MP0000516_abnormal_urinary_system1.30488726
48MP0005367_renal/urinary_system_phenotyp1.30488726
49MP0002282_abnormal_trachea_morphology1.30261641
50MP0003935_abnormal_craniofacial_develop1.27137969
51MP0003119_abnormal_digestive_system1.26588370
52MP0002108_abnormal_muscle_morphology1.25384318
53MP0000432_abnormal_head_morphology1.23510855
54* MP0003861_abnormal_nervous_system1.23452806
55MP0009384_cardiac_valve_regurgitation1.22867663
56MP0004134_abnormal_chest_morphology1.22689766
57MP0003938_abnormal_ear_development1.21789119
58MP0002116_abnormal_craniofacial_bone1.21592394
59MP0000537_abnormal_urethra_morphology1.19083987
60MP0003950_abnormal_plasma_membrane1.18470755
61MP0010352_gastrointestinal_tract_polyps1.17700419
62MP0001243_abnormal_dermal_layer1.15844501
63MP0000749_muscle_degeneration1.14855757
64MP0002084_abnormal_developmental_patter1.13513972
65MP0003115_abnormal_respiratory_system1.12023322
66MP0001879_abnormal_lymphatic_vessel1.11498099
67* MP0002085_abnormal_embryonic_tissue1.11386739
68MP0004858_abnormal_nervous_system1.10392514
69MP0002177_abnormal_outer_ear1.10331829
70MP0010386_abnormal_urinary_bladder1.09214092
71MP0005248_abnormal_Harderian_gland1.07782120
72MP0008932_abnormal_embryonic_tissue1.07161833
73MP0002114_abnormal_axial_skeleton1.06976503
74MP0003635_abnormal_synaptic_transmissio1.06210000
75MP0000733_abnormal_muscle_development1.06089898
76MP0002877_abnormal_melanocyte_morpholog1.05704195
77MP0004270_analgesia1.04798287
78MP0008789_abnormal_olfactory_epithelium1.04601729
79MP0004084_abnormal_cardiac_muscle1.04170081
80MP0002111_abnormal_tail_morphology1.00777816
81MP0004197_abnormal_fetal_growth/weight/0.99089191
82MP0002184_abnormal_innervation0.96909043
83MP0005187_abnormal_penis_morphology0.94943343
84MP0002896_abnormal_bone_mineralization0.93385177
85MP0003091_abnormal_cell_migration0.93076051
86MP0000163_abnormal_cartilage_morphology0.92138169
87MP0005595_abnormal_vascular_smooth0.91995698
88* MP0002152_abnormal_brain_morphology0.91144947
89MP0005197_abnormal_uvea_morphology0.90922404
90MP0005394_taste/olfaction_phenotype0.90662530
91MP0005499_abnormal_olfactory_system0.90662530
92MP0006292_abnormal_olfactory_placode0.90502448
93MP0004233_abnormal_muscle_weight0.89314221
94MP0000631_abnormal_neuroendocrine_gland0.89066129
95MP0002081_perinatal_lethality0.88310283
96MP0001984_abnormal_olfaction0.88203638
97MP0003890_abnormal_embryonic-extraembry0.87511059
98MP0000759_abnormal_skeletal_muscle0.86898725
99MP0000462_abnormal_digestive_system0.85942451
100MP0003111_abnormal_nucleus_morphology0.85753787
101MP0000003_abnormal_adipose_tissue0.84565360
102MP0001730_embryonic_growth_arrest0.84327362
103MP0000350_abnormal_cell_proliferation0.84292648
104MP0002295_abnormal_pulmonary_circulatio0.83505335
105* MP0002109_abnormal_limb_morphology0.82652051
106MP0002128_abnormal_blood_circulation0.82402683
107MP0002063_abnormal_learning/memory/cond0.82303491
108MP0000955_abnormal_spinal_cord0.81960407
109MP0002234_abnormal_pharynx_morphology0.80399323
110MP0000762_abnormal_tongue_morphology0.78925110
111MP0009703_decreased_birth_body0.78619681
112* MP0002115_abnormal_skeleton_extremities0.78479682
113MP0005380_embryogenesis_phenotype0.78440452
114MP0001672_abnormal_embryogenesis/_devel0.78440452
115MP0004885_abnormal_endolymph0.78302121
116MP0002697_abnormal_eye_size0.78127152
117MP0001697_abnormal_embryo_size0.77948917
118MP0003880_abnormal_central_pattern0.76765230
119MP0005076_abnormal_cell_differentiation0.75777705
120MP0010368_abnormal_lymphatic_system0.75474604
121MP0001915_intracranial_hemorrhage0.74427926
122* MP0005193_abnormal_anterior_eye0.68127822
123MP0001614_abnormal_blood_vessel0.67431939
124MP0002269_muscular_atrophy0.65932090
125* MP0002113_abnormal_skeleton_development0.65275068
126MP0002925_abnormal_cardiovascular_devel0.65146063
127MP0004087_abnormal_muscle_fiber0.65075130
128MP0004036_abnormal_muscle_relaxation0.64987321
129MP0001661_extended_life_span0.64947258
130* MP0002092_abnormal_eye_morphology0.63947061
131MP0001177_atelectasis0.63367921
132MP0005620_abnormal_muscle_contractility0.63260867
133MP0004957_abnormal_blastocyst_morpholog0.62566602
134* MP0001286_abnormal_eye_development0.62222441
135MP0001348_abnormal_lacrimal_gland0.59863256
136MP0000538_abnormal_urinary_bladder0.59606966
137MP0000747_muscle_weakness0.59250464
138MP0001849_ear_inflammation0.58665833
139MP0001270_distended_abdomen0.58200667
140MP0006138_congestive_heart_failure0.57071935

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.67381135
2Premature rupture of membranes (HP:0001788)5.34176903
3Vascular tortuosity (HP:0004948)3.82545074
4Shallow orbits (HP:0000586)3.64984415
5Arterial tortuosity (HP:0005116)3.43117768
6Follicular hyperkeratosis (HP:0007502)3.35150509
7Type 1 muscle fiber predominance (HP:0003803)3.31603396
8Abnormality of the labia minora (HP:0012880)3.26849367
9Genu recurvatum (HP:0002816)3.14489320
10Abnormality of dentin (HP:0010299)3.13654263
11Soft skin (HP:0000977)3.11754569
12Aortic regurgitation (HP:0001659)2.89205402
13Broad metatarsal (HP:0001783)2.87208470
14Neonatal short-limb short stature (HP:0008921)2.70443898
15Bladder diverticulum (HP:0000015)2.69886370
16Spondylolisthesis (HP:0003302)2.67171251
17Aortic dissection (HP:0002647)2.65711003
18Ankle contracture (HP:0006466)2.62574725
19Osteolytic defects of the phalanges of the hand (HP:0009771)2.56295946
20Osteolytic defects of the hand bones (HP:0009699)2.56295946
21Microglossia (HP:0000171)2.52848942
22Slender build (HP:0001533)2.51940295
23Ulnar bowing (HP:0003031)2.40870144
24Peritonitis (HP:0002586)2.39585482
25Overgrowth (HP:0001548)2.35260999
26Elbow flexion contracture (HP:0002987)2.30900870
27Absent frontal sinuses (HP:0002688)2.22657577
28Mitral regurgitation (HP:0001653)2.20673999
29Hyperextensible skin (HP:0000974)2.19596631
30Increased variability in muscle fiber diameter (HP:0003557)2.19273827
31Mildly elevated creatine phosphokinase (HP:0008180)2.15824620
32Abnormality of the astrocytes (HP:0100707)2.14460038
33Astrocytoma (HP:0009592)2.14460038
34Atrophic scars (HP:0001075)2.14314387
35Biconcave vertebral bodies (HP:0004586)2.14007702
36Wormian bones (HP:0002645)2.13150821
37* Abnormality of the acetabulum (HP:0003170)2.13144609
38Mild short stature (HP:0003502)2.12980063
39* Coronal craniosynostosis (HP:0004440)2.11903367
40Bowel diverticulosis (HP:0005222)2.10871770
41Dilatation of the ascending aorta (HP:0005111)2.09568892
42* Supernumerary spleens (HP:0009799)2.08806049
43Aortic valve stenosis (HP:0001650)2.08235495
44Round ear (HP:0100830)2.04422803
45Short 4th metacarpal (HP:0010044)2.03596541
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03596541
47Ectopia lentis (HP:0001083)2.02356957
48Spinal rigidity (HP:0003306)2.01512663
49Mitral stenosis (HP:0001718)2.01261682
50Fragile skin (HP:0001030)1.99678966
51Wrist flexion contracture (HP:0001239)1.98992464
52Broad long bones (HP:0005622)1.98035456
53Aneurysm (HP:0002617)1.97439371
54Blue sclerae (HP:0000592)1.94167926
55Breech presentation (HP:0001623)1.93964108
56Delayed cranial suture closure (HP:0000270)1.93513480
57Cerebral aneurysm (HP:0004944)1.93121239
58Camptodactyly of toe (HP:0001836)1.92128086
59* Abnormality of the phalanges of the hallux (HP:0010057)1.89169993
60Renal duplication (HP:0000075)1.88209350
61Flat cornea (HP:0007720)1.87759560
62Infantile muscular hypotonia (HP:0008947)1.87730385
63Limb-girdle muscle weakness (HP:0003325)1.87540927
64Abnormal delivery (HP:0001787)1.86635378
65Abnormality of skeletal muscle fiber size (HP:0012084)1.85883019
66Spinal cord lesions (HP:0100561)1.84992162
67Syringomyelia (HP:0003396)1.84992162
68Hypoplasia of the iris (HP:0007676)1.84456134
69Hypoventilation (HP:0002791)1.83860119
70Mesomelia (HP:0003027)1.83579204
71Short 1st metacarpal (HP:0010034)1.83248669
72Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83248669
73Ependymoma (HP:0002888)1.83227033
74Protruding ear (HP:0000411)1.81057119
75Cardiovascular calcification (HP:0011915)1.79332941
76Limited hip movement (HP:0008800)1.79307183
77Bell-shaped thorax (HP:0001591)1.79064096
78Delayed closure of the anterior fontanelle (HP:0001476)1.78792419
79Natal tooth (HP:0000695)1.77548967
80Aortic aneurysm (HP:0004942)1.76631340
81Knee flexion contracture (HP:0006380)1.76346176
82Mitral valve prolapse (HP:0001634)1.76088275
83Broad phalanx (HP:0006009)1.75914726
84Adrenal hypoplasia (HP:0000835)1.74679731
85Broad thumb (HP:0011304)1.74409612
86Relative macrocephaly (HP:0004482)1.74212268
87Disproportionate tall stature (HP:0001519)1.73631220
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72323418
89Redundant skin (HP:0001582)1.71127835
90Hepatoblastoma (HP:0002884)1.70655798
91Abdominal situs inversus (HP:0003363)1.69560006
92Abnormality of abdominal situs (HP:0011620)1.69560006
93Inguinal hernia (HP:0000023)1.69531840
94Selective tooth agenesis (HP:0001592)1.69336500
95Achilles tendon contracture (HP:0001771)1.68588440
96Deformed tarsal bones (HP:0008119)1.67752949
97Osteoarthritis (HP:0002758)1.67694293
98Fused cervical vertebrae (HP:0002949)1.67121216
99Morphological abnormality of the middle ear (HP:0008609)1.66669197
100Abnormality of the antihelix (HP:0009738)1.66338726
101* Pulmonic stenosis (HP:0001642)1.65497718
102Insidious onset (HP:0003587)1.64776857
103Termporal pattern (HP:0011008)1.64776857
104Broad finger (HP:0001500)1.63851492
105Abnormality of the peritoneum (HP:0002585)1.63746222
106Decreased skull ossification (HP:0004331)1.63513265
107Cervical subluxation (HP:0003308)1.61611283
108Glioma (HP:0009733)1.61571570
109Deviation of the hallux (HP:0010051)1.61513430
110Calcaneovalgus deformity (HP:0001848)1.61057512
111Increased connective tissue (HP:0009025)1.60982369
112Broad phalanges of the hand (HP:0009768)1.60131669
113Facial hemangioma (HP:0000329)1.59865759
114Pulmonary artery stenosis (HP:0004415)1.59813152
115Rhizomelia (HP:0008905)1.57904332
116Abnormality of skull ossification (HP:0002703)1.57900397
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.57841341
118Neoplasm of the oral cavity (HP:0100649)1.57811726
119Delayed gross motor development (HP:0002194)1.57771315
120Joint laxity (HP:0001388)1.56991222
121* Preaxial foot polydactyly (HP:0001841)1.56615208
122Oligodactyly (HP:0012165)1.56042734
123Focal seizures (HP:0007359)1.53598082
124Striae distensae (HP:0001065)1.53517033
125Nonimmune hydrops fetalis (HP:0001790)1.53360699
126Aplasia of the phalanges of the hand (HP:0009802)1.53050732
127Aplasia involving bones of the extremities (HP:0009825)1.53050732
128Aplasia involving bones of the upper limbs (HP:0009823)1.53050732
129Hallux valgus (HP:0001822)1.52706523
130Short nail (HP:0001799)1.52533644
131Atonic seizures (HP:0010819)1.52405175
132Bronchomalacia (HP:0002780)1.51676136
133Bifid tongue (HP:0010297)1.51563158
134Hypoplastic labia majora (HP:0000059)1.50907475
135Short middle phalanx of the 5th finger (HP:0004220)1.50457667
136Abnormality of the 4th metacarpal (HP:0010012)1.50330008
137Spinal cord compression (HP:0002176)1.49976915
138Wide anterior fontanel (HP:0000260)1.48580509
139Broad toe (HP:0001837)1.48260906
140Shoulder girdle muscle weakness (HP:0003547)1.47704818
141Aplasia/hypoplasia of the humerus (HP:0006507)1.47241927
142Abnormal number of incisors (HP:0011064)1.46312630
143Broad ribs (HP:0000885)1.46155229
144Buphthalmos (HP:0000557)1.45829218
145Short humerus (HP:0005792)1.44066066
146Short palm (HP:0004279)1.43742918
147Fibular aplasia (HP:0002990)1.43614982
148Vertebral compression fractures (HP:0002953)1.43448038
149Sparse lateral eyebrow (HP:0005338)1.43079733
150Short phalanx of the thumb (HP:0009660)1.43064189
151Rib fusion (HP:0000902)1.42177153
152Congenital glaucoma (HP:0001087)1.42074387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.04005148
2LATS23.72736604
3LATS13.14887501
4NEK92.98426619
5DDR22.75988316
6PRKD32.11083580
7BUB12.06458591
8CDK122.03859967
9PLK22.00603009
10DMPK1.98666085
11PBK1.96625101
12CDC71.85303546
13STK38L1.81169004
14PDGFRA1.70927703
15PAK31.65598356
16TTK1.64716127
17FER1.64218337
18STK31.54738141
19PNCK1.54590620
20PASK1.52262508
21LIMK11.52110400
22AKT31.51211917
23PAK61.46131717
24PAK21.43807565
25MARK11.37836205
26EPHA21.36224750
27EPHA41.34502582
28ALK1.33620130
29NTRK31.33030745
30BCR1.31897653
31MET1.31286469
32TYRO31.28978331
33NTRK11.26759625
34PLK31.25282148
35TGFBR21.23098032
36DYRK21.18962542
37WEE11.16533535
38CDK141.15916322
39BRSK21.15513473
40MAP3K41.12789805
41CASK1.12116690
42MAP3K121.11833793
43CHEK21.09004059
44MKNK11.05491021
45PTK21.04362901
46MINK11.04129355
47CAMK1G1.03856978
48ERBB31.03251841
49TESK21.02382016
50TAF11.01358937
51MAP3K91.00647885
52ERBB41.00575381
53DYRK30.98220276
54CDK150.98012645
55EIF2AK30.96335096
56SCYL20.94727753
57CDK180.93892517
58CSNK1A1L0.92140966
59KSR10.90965319
60UHMK10.89829070
61FLT30.88884064
62CDK11A0.88843534
63PLK10.88662950
64MST1R0.88330116
65CDK70.86654542
66TRPM70.85597384
67RIPK10.83220824
68PTK2B0.83052333
69WNK10.81844993
70ROCK10.81427060
71CHEK10.81146038
72TESK10.81072501
73MOS0.79916268
74FGFR10.79120654
75TAOK10.78867230
76MAPK130.78491843
77NEK20.78359971
78BRAF0.77833783
79MELK0.76624321
80MTOR0.76438812
81AURKA0.76108134
82MAPKAPK50.75973579
83BRSK10.75288081
84ILK0.74959776
85PRKD20.74118087
86CAMKK10.73828809
87MAP3K60.73679618
88ICK0.72761884
89CSNK1E0.70398983
90AURKB0.68358135
91BMX0.65700837
92CSNK1G10.63654762
93STK240.63020940
94CAMK2G0.62807327
95NTRK20.61784002
96STK390.61411748
97PAK10.60744031
98SRPK10.60642476
99EPHB20.59811454
100STK380.59067030
101CSNK1G30.58199181
102PKN20.57933036
103TRIB30.57919269
104KSR20.57455129
105ROCK20.57073312
106ABL20.56979857
107ATM0.56305079
108CAMK2B0.55498953
109GSK3A0.55300498
110DAPK30.55299920
111PIK3CG0.54724188
112CDK20.54196684
113PRPF4B0.54149217
114BRD40.52414393
115CDK10.52292937
116EIF2AK10.52240415
117CLK10.52084625
118CSNK1D0.52018442
119CDK60.51615346
120CDC42BPA0.50214489
121NEK10.49638671
122MAP2K10.49591629
123CSNK1G20.48978369
124MARK20.48795955
125MAPK100.48788284
126PDGFRB0.48622794
127PRKCE0.47233071
128TTN0.46748510
129CDK80.45778353
130PRKDC0.45202654
131PAK40.44830911
132PRKCG0.44725459
133CAMK2D0.44409258
134PLK40.42419451
135MAP3K100.39612237
136PRKG20.39286275
137STK40.37850601
138EEF2K0.37185983
139RAF10.36293226
140TGFBR10.35625012

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.22044486
2* Hedgehog signaling pathway_Homo sapiens_hsa043402.20915077
3Hippo signaling pathway_Homo sapiens_hsa043902.12820088
4Oocyte meiosis_Homo sapiens_hsa041141.74942343
5Axon guidance_Homo sapiens_hsa043601.73914006
6Olfactory transduction_Homo sapiens_hsa047401.72615139
7ECM-receptor interaction_Homo sapiens_hsa045121.70205042
8Small cell lung cancer_Homo sapiens_hsa052221.67072980
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63901159
10TGF-beta signaling pathway_Homo sapiens_hsa043501.62694548
11RNA transport_Homo sapiens_hsa030131.59999798
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59910863
13Nicotine addiction_Homo sapiens_hsa050331.59291249
14Wnt signaling pathway_Homo sapiens_hsa043101.58016775
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56998869
16Cell cycle_Homo sapiens_hsa041101.56549117
17MicroRNAs in cancer_Homo sapiens_hsa052061.56361575
18Melanogenesis_Homo sapiens_hsa049161.53843586
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51921289
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48551080
21mRNA surveillance pathway_Homo sapiens_hsa030151.45308011
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45279970
23Bladder cancer_Homo sapiens_hsa052191.43600802
24Glutamatergic synapse_Homo sapiens_hsa047241.35724731
25Nitrogen metabolism_Homo sapiens_hsa009101.33772050
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31499639
27GABAergic synapse_Homo sapiens_hsa047271.31435873
28Melanoma_Homo sapiens_hsa052181.31319477
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31283596
30Glioma_Homo sapiens_hsa052141.30987911
31Long-term potentiation_Homo sapiens_hsa047201.29493582
32Focal adhesion_Homo sapiens_hsa045101.28513684
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27314256
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26802963
35Proteoglycans in cancer_Homo sapiens_hsa052051.26674542
36Long-term depression_Homo sapiens_hsa047301.24291314
37Steroid biosynthesis_Homo sapiens_hsa001001.24157112
38Dorso-ventral axis formation_Homo sapiens_hsa043201.24121341
39Gap junction_Homo sapiens_hsa045401.23510911
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23470207
41Circadian entrainment_Homo sapiens_hsa047131.20529764
42Dilated cardiomyopathy_Homo sapiens_hsa054141.19129869
43ErbB signaling pathway_Homo sapiens_hsa040121.18870492
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18273891
45p53 signaling pathway_Homo sapiens_hsa041151.17866997
46Dopaminergic synapse_Homo sapiens_hsa047281.16249690
47Spliceosome_Homo sapiens_hsa030401.14453289
48Non-homologous end-joining_Homo sapiens_hsa034501.13835972
49GnRH signaling pathway_Homo sapiens_hsa049121.13081552
50Adherens junction_Homo sapiens_hsa045201.10990961
51Tight junction_Homo sapiens_hsa045301.10901432
52Amphetamine addiction_Homo sapiens_hsa050311.09784451
53One carbon pool by folate_Homo sapiens_hsa006701.08006936
54Estrogen signaling pathway_Homo sapiens_hsa049151.06824467
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.06327321
56Renal cell carcinoma_Homo sapiens_hsa052111.04488188
57Ovarian steroidogenesis_Homo sapiens_hsa049131.01942612
58Synaptic vesicle cycle_Homo sapiens_hsa047211.01045874
59Morphine addiction_Homo sapiens_hsa050320.99669312
60Colorectal cancer_Homo sapiens_hsa052100.98574014
61Basal transcription factors_Homo sapiens_hsa030220.97245181
62Protein export_Homo sapiens_hsa030600.96583599
63Rap1 signaling pathway_Homo sapiens_hsa040150.95230508
64Mismatch repair_Homo sapiens_hsa034300.93841114
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90939451
66Ras signaling pathway_Homo sapiens_hsa040140.90743489
67Cholinergic synapse_Homo sapiens_hsa047250.90633458
68Pathways in cancer_Homo sapiens_hsa052000.90124786
69Insulin secretion_Homo sapiens_hsa049110.90086162
70Serotonergic synapse_Homo sapiens_hsa047260.89710354
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88735703
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86964806
73Cocaine addiction_Homo sapiens_hsa050300.86956641
74Taste transduction_Homo sapiens_hsa047420.86776666
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85439833
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84945031
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84576021
78Oxytocin signaling pathway_Homo sapiens_hsa049210.84073220
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.83210241
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83191937
81Prostate cancer_Homo sapiens_hsa052150.82224088
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81998245
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81473384
84N-Glycan biosynthesis_Homo sapiens_hsa005100.81324876
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81008778
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80025678
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.78974995
88Fanconi anemia pathway_Homo sapiens_hsa034600.77897534
89Lysine degradation_Homo sapiens_hsa003100.77603329
90Circadian rhythm_Homo sapiens_hsa047100.76897844
91RNA polymerase_Homo sapiens_hsa030200.76405256
92cAMP signaling pathway_Homo sapiens_hsa040240.75386802
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73265532
94Endometrial cancer_Homo sapiens_hsa052130.71910473
95Alcoholism_Homo sapiens_hsa050340.70268104
96Homologous recombination_Homo sapiens_hsa034400.67233254
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66756953
98MAPK signaling pathway_Homo sapiens_hsa040100.66547293
99Gastric acid secretion_Homo sapiens_hsa049710.66075657
100Nucleotide excision repair_Homo sapiens_hsa034200.66045494
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64507491
102Vibrio cholerae infection_Homo sapiens_hsa051100.63411222
103HTLV-I infection_Homo sapiens_hsa051660.62619663
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.61524875
105Thyroid cancer_Homo sapiens_hsa052160.59289323
106Chronic myeloid leukemia_Homo sapiens_hsa052200.57907226
107Salivary secretion_Homo sapiens_hsa049700.57678492
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57502296
109Protein digestion and absorption_Homo sapiens_hsa049740.57172683
110Amoebiasis_Homo sapiens_hsa051460.56869547
111Thyroid hormone synthesis_Homo sapiens_hsa049180.55615720
112Vitamin B6 metabolism_Homo sapiens_hsa007500.55459525
113Biosynthesis of amino acids_Homo sapiens_hsa012300.53334953
114Pancreatic cancer_Homo sapiens_hsa052120.52847124
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51631592
116Prion diseases_Homo sapiens_hsa050200.50667041
117DNA replication_Homo sapiens_hsa030300.50130671
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47191123
119AMPK signaling pathway_Homo sapiens_hsa041520.46628696
120Pyruvate metabolism_Homo sapiens_hsa006200.44876967
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44659130
122Selenocompound metabolism_Homo sapiens_hsa004500.43065400
123Shigellosis_Homo sapiens_hsa051310.35807822
124Endocytosis_Homo sapiens_hsa041440.34539456
125Inositol phosphate metabolism_Homo sapiens_hsa005620.34402999
126Renin-angiotensin system_Homo sapiens_hsa046140.33427256
127Propanoate metabolism_Homo sapiens_hsa006400.32777151
128Sulfur metabolism_Homo sapiens_hsa009200.32185512
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31417636
130mTOR signaling pathway_Homo sapiens_hsa041500.30934438

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