RAB25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.17462641
2regulation of water loss via skin (GO:0033561)8.02652562
3sphingoid metabolic process (GO:0046519)6.22352977
4multicellular organismal water homeostasis (GO:0050891)6.18051520
5intestinal epithelial cell development (GO:0060576)6.10626180
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.87546413
7interferon-gamma secretion (GO:0072643)5.86633207
8keratinization (GO:0031424)5.83887129
9hemidesmosome assembly (GO:0031581)5.73775720
10keratinocyte proliferation (GO:0043616)5.49360782
11diol metabolic process (GO:0034311)5.48058666
12negative regulation of keratinocyte proliferation (GO:0010839)5.41322463
13water homeostasis (GO:0030104)5.08517288
14sphingosine metabolic process (GO:0006670)5.05579173
15keratinocyte differentiation (GO:0030216)5.04270760
16regulation of chemokine secretion (GO:0090196)4.89088082
17calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.72652408
18keratinocyte development (GO:0003334)4.62203289
19negative regulation of epidermis development (GO:0045683)4.61900434
20molting cycle (GO:0042303)4.52168442
21hair cycle (GO:0042633)4.52168442
22regulation of phospholipase A2 activity (GO:0032429)4.47197790
23regulation of apoptotic process involved in morphogenesis (GO:1902337)4.46597767
24polyketide metabolic process (GO:0030638)4.37754048
25doxorubicin metabolic process (GO:0044598)4.37754048
26daunorubicin metabolic process (GO:0044597)4.37754048
27negative regulation of epidermal cell differentiation (GO:0045605)4.30247981
28epidermal cell differentiation (GO:0009913)4.17742662
29hormone catabolic process (GO:0042447)4.14613433
30positive regulation of interleukin-8 secretion (GO:2000484)4.14134693
31ribosomal small subunit biogenesis (GO:0042274)4.10616354
32primary alcohol catabolic process (GO:0034310)4.06689163
33phosphatidylserine acyl-chain remodeling (GO:0036150)4.03636558
34gap junction assembly (GO:0016264)4.02551499
35phosphatidylinositol acyl-chain remodeling (GO:0036149)3.95769029
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.95048742
37muscle organ morphogenesis (GO:0048644)3.92919142
38regulation of ruffle assembly (GO:1900027)3.91715488
39glandular epithelial cell differentiation (GO:0002067)3.88614638
40somite rostral/caudal axis specification (GO:0032525)3.82840272
41icosanoid secretion (GO:0032309)3.81048565
42arachidonic acid secretion (GO:0050482)3.81048565
43cyclooxygenase pathway (GO:0019371)3.77849362
44epithelial cell-cell adhesion (GO:0090136)3.77694220
45positive regulation of epidermal cell differentiation (GO:0045606)3.68119981
46viral transcription (GO:0019083)3.63834699
47epidermis development (GO:0008544)3.62550557
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60701434
49ectoderm development (GO:0007398)3.55678544
50protein targeting to ER (GO:0045047)3.53707960
51cotranslational protein targeting to membrane (GO:0006613)3.48649446
52translational termination (GO:0006415)3.41608123
53regulation of interleukin-8 secretion (GO:2000482)3.40544761
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.40127940
55tight junction assembly (GO:0070830)3.39658669
56positive regulation of epidermis development (GO:0045684)3.39192671
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38059148
58glucosamine-containing compound catabolic process (GO:1901072)3.37766478
59regulation of epidermis development (GO:0045682)3.37464871
60GDP-mannose metabolic process (GO:0019673)3.37060425
61transepithelial transport (GO:0070633)3.35330823
62protein autoprocessing (GO:0016540)3.35298757
63regulation of keratinocyte proliferation (GO:0010837)3.34917245
64polarized epithelial cell differentiation (GO:0030859)3.34553978
65NADH metabolic process (GO:0006734)3.34259029
66negative regulation of cell fate commitment (GO:0010454)3.33238492
67peptide cross-linking (GO:0018149)3.32439235
68establishment of apical/basal cell polarity (GO:0035089)3.31221275
69protein localization to endoplasmic reticulum (GO:0070972)3.27818271
70cell-cell junction assembly (GO:0007043)3.26918039
71intermediate filament organization (GO:0045109)3.24640725
72negative regulation of interleukin-2 production (GO:0032703)3.23763635
73regulation of epidermal cell differentiation (GO:0045604)3.23702804
74ventricular cardiac muscle cell action potential (GO:0086005)3.22131195
75phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.21431191
76vitamin transmembrane transport (GO:0035461)3.21115322
77regulation of keratinocyte differentiation (GO:0045616)3.20256298
78notochord development (GO:0030903)3.19970969
79icosanoid transport (GO:0071715)3.19449227
80fatty acid derivative transport (GO:1901571)3.19449227
81pharyngeal system development (GO:0060037)3.17238990
82regulation of cardioblast differentiation (GO:0051890)3.15935127
83branching involved in mammary gland duct morphogenesis (GO:0060444)3.15371155
84skin morphogenesis (GO:0043589)3.13550732
85O-glycan processing (GO:0016266)3.11531092
86amyloid precursor protein metabolic process (GO:0042982)3.11045327
87hepatocyte apoptotic process (GO:0097284)3.09960915
88regulation of cell proliferation involved in kidney development (GO:1901722)3.04176768
89establishment of tissue polarity (GO:0007164)2.99635181
90establishment of planar polarity (GO:0001736)2.99635181
91columnar/cuboidal epithelial cell development (GO:0002066)2.98658867
92prostaglandin metabolic process (GO:0006693)2.98109841
93prostanoid metabolic process (GO:0006692)2.98109841
94positive regulation of keratinocyte differentiation (GO:0045618)2.97561094
95phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.95711013
96apical protein localization (GO:0045176)2.94854139
97ear development (GO:0043583)2.93022350
98epithelial cell maturation (GO:0002070)2.92980099
99cytidine deamination (GO:0009972)2.91061283
100cytidine metabolic process (GO:0046087)2.91061283
101cytidine catabolic process (GO:0006216)2.91061283
102surfactant homeostasis (GO:0043129)2.90768935
103prostaglandin biosynthetic process (GO:0001516)2.89756532
104prostanoid biosynthetic process (GO:0046457)2.89756532
105aminoglycoside antibiotic metabolic process (GO:0030647)2.89315199
106negative regulation of cell fate specification (GO:0009996)2.88844333
107thyroid hormone generation (GO:0006590)2.88109389
108viral life cycle (GO:0019058)2.87533415
109positive regulation of glycoprotein metabolic process (GO:1903020)2.87022466
110ethanol metabolic process (GO:0006067)2.83407642
111chemical homeostasis within a tissue (GO:0048875)2.82922988
112phosphatidylcholine acyl-chain remodeling (GO:0036151)2.82748276
113sphingomyelin metabolic process (GO:0006684)2.82727992
114negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.81695238
115regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.81486533
116cardiac right ventricle morphogenesis (GO:0003215)2.81107857
117Golgi transport vesicle coating (GO:0048200)2.79628017
118COPI coating of Golgi vesicle (GO:0048205)2.79628017
119trophectodermal cell differentiation (GO:0001829)2.77824354
120regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.77706124
121pyrimidine-containing compound transmembrane transport (GO:0072531)2.76406138
122proline biosynthetic process (GO:0006561)2.74303207
123epithelial cell differentiation involved in prostate gland development (GO:0060742)2.72864427
124positive regulation of vesicle fusion (GO:0031340)2.72633465
125diterpenoid biosynthetic process (GO:0016102)2.72577067
126hair follicle morphogenesis (GO:0031069)2.71380895
127nucleotide-sugar biosynthetic process (GO:0009226)2.69891208
1283-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.68941159
129purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.68941159
130lung lobe morphogenesis (GO:0060463)2.68429212
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.65715620
132glutathione biosynthetic process (GO:0006750)2.65714100
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65145207
134amyloid precursor protein catabolic process (GO:0042987)2.60650566
135regulation of heart rate by cardiac conduction (GO:0086091)2.58335711
136auditory receptor cell differentiation (GO:0042491)2.57835825
137asymmetric protein localization (GO:0008105)2.56458111
138negative regulation of transcription by competitive promoter binding (GO:0010944)2.55783585
139membrane budding (GO:0006900)2.55084835
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54211427
141negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.53452352
142regulation of cholesterol homeostasis (GO:2000188)2.50422433
143biotin metabolic process (GO:0006768)2.49876581
144endosome organization (GO:0007032)2.48894971
145mammary gland epithelial cell differentiation (GO:0060644)2.48381068
146activation of Rac GTPase activity (GO:0032863)2.48359017
147glutathione derivative metabolic process (GO:1901685)2.45865623
148glutathione derivative biosynthetic process (GO:1901687)2.45865623
149cell differentiation involved in embryonic placenta development (GO:0060706)2.45802878
150establishment or maintenance of apical/basal cell polarity (GO:0035088)2.44603078
151establishment or maintenance of bipolar cell polarity (GO:0061245)2.44603078
152regulation of Cdc42 GTPase activity (GO:0043088)2.44386617
153lipoxygenase pathway (GO:0019372)2.43595154
154establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.42560287
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42506296
156desmosome organization (GO:0002934)10.6577417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.16458280
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.89260956
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.89260956
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.89260956
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15427818
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.96194260
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.67054081
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.65372334
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.50850091
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.31714456
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22063376
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.21239156
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.16906239
14AR_21909140_ChIP-Seq_LNCAP_Human2.13279270
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08745736
16SOX9_24532713_ChIP-Seq_HFSC_Mouse2.07200722
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.00230592
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.00122944
19TP63_17297297_ChIP-ChIP_HaCaT_Human13.1987264
20GATA4_25053715_ChIP-Seq_YYC3_Human1.85314899
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.82795732
22GATA6_25053715_ChIP-Seq_YYC3_Human1.82751931
23TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80574052
24* SOX2_20726797_ChIP-Seq_SW620_Human1.76631395
25* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68502973
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.67721366
27RACK7_27058665_Chip-Seq_MCF-7_Human1.63292195
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62933300
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61435472
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61435472
31ELF5_23300383_ChIP-Seq_T47D_Human1.61378670
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58778464
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58464675
34TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55148010
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52573624
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52242238
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.48010158
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47745271
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46705049
40KLF5_25053715_ChIP-Seq_YYC3_Human1.46035899
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.43410761
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.41359532
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41252935
44CLOCK_20551151_ChIP-Seq_293T_Human1.40381909
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38828234
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37853072
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35122392
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32961257
49* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32088697
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31563873
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29068414
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28846855
53* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28317065
54TP63_22573176_ChIP-Seq_HFKS_Human1.27019063
55ATF3_27146783_Chip-Seq_COLON_Human1.26884613
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26191185
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26041791
58ZNF263_19887448_ChIP-Seq_K562_Human1.25376331
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18491503
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17607080
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17416098
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.17235286
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15925378
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15533732
65NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15422004
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12310967
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12302262
68TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08407650
69CREB1_26743006_Chip-Seq_LNCaP_Human1.07698328
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05474373
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05362070
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04983262
73PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04162611
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.02593973
75ELK1_22589737_ChIP-Seq_MCF10A_Human0.98187939
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98174624
77STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97290317
78AHR_22903824_ChIP-Seq_MCF-7_Human0.97225954
79NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96735212
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95917856
81* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95019539
82KDM5A_27292631_Chip-Seq_BREAST_Human0.94245268
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93651782
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93629688
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.91912546
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91330990
87TP53_20018659_ChIP-ChIP_R1E_Mouse0.90652567
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89754912
89TP63_23658742_ChIP-Seq_EP156T_Human0.89304311
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89277277
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89262123
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89219940
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.88251823
94OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87059132
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85750586
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.85141496
97NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84960054
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.84931787
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84385848
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84217645
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84191079
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83673865
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83576479
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82953222
105BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82328035
106ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81740411
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81339782
108BCOR_27268052_Chip-Seq_Bcells_Human0.80482073
109CTCF_20526341_ChIP-Seq_ESCs_Human0.80357758
110LXR_22292898_ChIP-Seq_THP-1_Human0.80256282
111PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78008758
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77674683
113MYC_19079543_ChIP-ChIP_MESCs_Mouse0.77380692
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77201674
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76034369
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.76004402
117* CTCF_27219007_Chip-Seq_Bcells_Human0.75809249
118* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74393802
119P68_20966046_ChIP-Seq_HELA_Human0.73942346
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73766925
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73701755
122CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73255919
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.73238690
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72771387
125* CHD1_26751641_Chip-Seq_LNCaP_Human0.72082523
126KAP1_27257070_Chip-Seq_ESCs_Mouse0.71991885
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.71839929
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71767674
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70531186
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.69017458
131SMC4_20622854_ChIP-Seq_HELA_Human0.68644918
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68091493
133POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.67483147
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.67113733
135FOXA1_25552417_ChIP-Seq_VCAP_Human0.66761505
136NANOG_20526341_ChIP-Seq_ESCs_Human0.65710466
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65656571
138PHF8_20622854_ChIP-Seq_HELA_Human0.65237695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.59791536
2MP0002254_reproductive_system_inflammat4.69101957
3MP0010234_abnormal_vibrissa_follicle4.46293667
4MP0003941_abnormal_skin_development3.60964165
5MP0004264_abnormal_extraembryonic_tissu3.54557841
6MP0005501_abnormal_skin_physiology3.45639239
7MP0002098_abnormal_vibrissa_morphology3.33616183
8MP0004381_abnormal_hair_follicle2.87766796
9MP0000383_abnormal_hair_follicle2.76657405
10MP0005275_abnormal_skin_tensile2.69064947
11MP0001216_abnormal_epidermal_layer2.67125190
12MP0005394_taste/olfaction_phenotype2.64191124
13MP0005499_abnormal_olfactory_system2.64191124
14MP0003453_abnormal_keratinocyte_physiol2.59398966
15MP0010678_abnormal_skin_adnexa2.59109266
16MP0002060_abnormal_skin_morphology2.43689734
17MP0000678_abnormal_parathyroid_gland2.40439451
18MP0000762_abnormal_tongue_morphology2.17955771
19MP0008789_abnormal_olfactory_epithelium2.14937983
20MP0003705_abnormal_hypodermis_morpholog2.11783433
21MP0000377_abnormal_hair_follicle2.06750188
22MP0000579_abnormal_nail_morphology2.06315207
23MP0002877_abnormal_melanocyte_morpholog2.06048848
24MP0010771_integument_phenotype2.03513461
25MP0001346_abnormal_lacrimal_gland2.03426904
26MP0000647_abnormal_sebaceous_gland1.88636489
27MP0000566_synostosis1.78545453
28MP0008004_abnormal_stomach_pH1.77401011
29MP0002277_abnormal_respiratory_mucosa1.74878471
30MP0003183_abnormal_peptide_metabolism1.71236805
31MP0010030_abnormal_orbit_morphology1.65744556
32MP0003011_delayed_dark_adaptation1.64599975
33MP0004043_abnormal_pH_regulation1.60866614
34MP0004782_abnormal_surfactant_physiolog1.56245448
35MP0003566_abnormal_cell_adhesion1.49899293
36MP0004947_skin_inflammation1.48756814
37MP0003283_abnormal_digestive_organ1.47750033
38MP0000613_abnormal_salivary_gland1.45172604
39MP0003191_abnormal_cellular_cholesterol1.44630767
40MP0000427_abnormal_hair_cycle1.42049204
41MP0005409_darkened_coat_color1.36285476
42* MP0000467_abnormal_esophagus_morphology1.34900659
43MP0001849_ear_inflammation1.34779082
44MP0002009_preneoplasia1.31229979
45MP0003315_abnormal_perineum_morphology1.30146415
46MP0005083_abnormal_biliary_tract1.28271920
47MP0003693_abnormal_embryo_hatching1.27221605
48MP0003890_abnormal_embryonic-extraembry1.27016483
49MP0009379_abnormal_foot_pigmentation1.26500325
50MP0001881_abnormal_mammary_gland1.22715256
51MP0000537_abnormal_urethra_morphology1.21525607
52* MP0010352_gastrointestinal_tract_polyps1.20562850
53MP0001666_abnormal_nutrient_absorption1.20412649
54MP0001873_stomach_inflammation1.17083091
55MP0009931_abnormal_skin_appearance1.15707986
56MP0005075_abnormal_melanosome_morpholog1.15624664
57MP0005257_abnormal_intraocular_pressure1.14643035
58MP0003878_abnormal_ear_physiology1.12032622
59MP0005377_hearing/vestibular/ear_phenot1.12032622
60MP0000367_abnormal_coat/_hair1.11698494
61MP0005365_abnormal_bile_salt1.11387291
62MP0001191_abnormal_skin_condition1.06733270
63MP0002233_abnormal_nose_morphology1.05770165
64MP0004858_abnormal_nervous_system1.04772619
65MP0002234_abnormal_pharynx_morphology1.03516632
66MP0000516_abnormal_urinary_system0.97251904
67MP0005367_renal/urinary_system_phenotyp0.97251904
68MP0002132_abnormal_respiratory_system0.95921964
69MP0001243_abnormal_dermal_layer0.92255450
70MP0005636_abnormal_mineral_homeostasis0.91836920
71MP0002139_abnormal_hepatobiliary_system0.86957504
72MP0001664_abnormal_digestion0.84968162
73MP0005023_abnormal_wound_healing0.83518706
74MP0005248_abnormal_Harderian_gland0.82004811
75MP0000462_abnormal_digestive_system0.81920895
76MP0003300_gastrointestinal_ulcer0.80942575
77MP0003806_abnormal_nucleotide_metabolis0.80394451
78MP0004019_abnormal_vitamin_homeostasis0.79854295
79MP0000490_abnormal_crypts_of0.79476525
80MP0004185_abnormal_adipocyte_glucose0.79251199
81MP0003638_abnormal_response/metabolism_0.78083909
82MP0004957_abnormal_blastocyst_morpholog0.77430371
83MP0000627_abnormal_mammary_gland0.76899990
84MP0005076_abnormal_cell_differentiation0.75672490
85MP0001727_abnormal_embryo_implantation0.75446285
86MP0000470_abnormal_stomach_morphology0.74823976
87MP0003123_paternal_imprinting0.74628506
88MP0001188_hyperpigmentation0.74541426
89MP0001756_abnormal_urination0.74214898
90MP0005085_abnormal_gallbladder_physiolo0.74115686
91MP0002249_abnormal_larynx_morphology0.74098546
92MP0001765_abnormal_ion_homeostasis0.73118008
93MP0001984_abnormal_olfaction0.71855213
94MP0003936_abnormal_reproductive_system0.71720399
95MP0000049_abnormal_middle_ear0.71490272
96MP0010155_abnormal_intestine_physiology0.71444391
97MP0010386_abnormal_urinary_bladder0.69609200
98MP0009840_abnormal_foam_cell0.69558377
99MP0006292_abnormal_olfactory_placode0.69092604
100MP0005220_abnormal_exocrine_pancreas0.68775673
101MP0009672_abnormal_birth_weight0.68716752
102MP0009053_abnormal_anal_canal0.67660902
103MP0002653_abnormal_ependyma_morphology0.67427788
104MP0003755_abnormal_palate_morphology0.67354909
105MP0008875_abnormal_xenobiotic_pharmacok0.66929322
106MP0003866_abnormal_defecation0.65500551
107MP0003718_maternal_effect0.65493300
108MP0009780_abnormal_chondrocyte_physiolo0.63690101
109MP0008961_abnormal_basal_metabolism0.63194075
110MP0005360_urolithiasis0.63027210
111MP0003938_abnormal_ear_development0.62504720
112MP0002166_altered_tumor_susceptibility0.61966803
113MP0005666_abnormal_adipose_tissue0.61902626
114MP0001340_abnormal_eyelid_morphology0.59979124
115* MP0000477_abnormal_intestine_morphology0.59782506
116MP0005508_abnormal_skeleton_morphology0.59431294
117MP0000538_abnormal_urinary_bladder0.59414195
118MP0003119_abnormal_digestive_system0.59195121
119MP0009643_abnormal_urine_homeostasis0.58775099
120MP0001270_distended_abdomen0.58771439
121MP0001944_abnormal_pancreas_morphology0.58753438
122MP0000432_abnormal_head_morphology0.57788774
123MP0005408_hypopigmentation0.57594585
124MP0002111_abnormal_tail_morphology0.55955818
125MP0002909_abnormal_adrenal_gland0.55277653
126MP0002876_abnormal_thyroid_physiology0.55082333
127MP0002693_abnormal_pancreas_physiology0.54768877
128MP0005451_abnormal_body_composition0.51617830
129MP0005670_abnormal_white_adipose0.50779425
130MP0002086_abnormal_extraembryonic_tissu0.49977713
131MP0001730_embryonic_growth_arrest0.49008909
132MP0002136_abnormal_kidney_physiology0.48569356
133MP0005332_abnormal_amino_acid0.47953969

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)5.89748622
2Right ventricular cardiomyopathy (HP:0011663)5.66705994
3Onycholysis (HP:0001806)5.21866496
4Woolly hair (HP:0002224)5.14729410
5Hypotrichosis (HP:0001006)5.04600704
6Plantar hyperkeratosis (HP:0007556)4.69420840
7Fragile nails (HP:0001808)4.42296851
8Alopecia of scalp (HP:0002293)4.32431476
9Milia (HP:0001056)4.04636567
10Congenital ichthyosiform erythroderma (HP:0007431)4.03419158
11Pili torti (HP:0003777)3.97325547
12Palmoplantar hyperkeratosis (HP:0000972)3.73572319
13Abnormal hemoglobin (HP:0011902)3.66613636
14Trismus (HP:0000211)3.58387256
15Curly hair (HP:0002212)3.55963987
16Bilateral microphthalmos (HP:0007633)3.51535385
17Palmar hyperkeratosis (HP:0010765)3.49112251
18Abnormality of the salivary glands (HP:0010286)3.42048446
19Oral leukoplakia (HP:0002745)3.28336572
20Popliteal pterygium (HP:0009756)3.25073268
21Sparse eyelashes (HP:0000653)3.22684581
22Abnormality of nail color (HP:0100643)3.11974212
23Hypoplastic labia majora (HP:0000059)3.09038789
24Abnormality of small intestinal villus morphology (HP:0011472)3.06889013
25Villous atrophy (HP:0011473)3.06889013
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01182406
27Parakeratosis (HP:0001036)2.99148235
28Ventricular tachycardia (HP:0004756)2.95982021
29Hyperactive renin-angiotensin system (HP:0000841)2.90411179
30Multiple enchondromatosis (HP:0005701)2.86667207
31Erythema (HP:0010783)2.84968020
32Abnormal blistering of the skin (HP:0008066)2.82004533
33Nail dystrophy (HP:0008404)2.81645313
34Skin pits (HP:0100276)2.80732076
35Amelogenesis imperfecta (HP:0000705)2.79256195
36Absent eyelashes (HP:0000561)2.78171665
37Abnormality of the labia majora (HP:0012881)2.77195534
38Increased IgE level (HP:0003212)2.73630445
39Abnormality of the distal phalanges of the toes (HP:0010182)2.72773756
40Conjunctival hamartoma (HP:0100780)2.72765677
41Hyperinsulinemic hypoglycemia (HP:0000825)2.64114655
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63707918
43Atrophic scars (HP:0001075)2.61482286
44Corneal erosion (HP:0200020)2.60140467
45Sparse scalp hair (HP:0002209)2.59949885
46Abnormality of the dental root (HP:0006486)2.59796699
47Taurodontia (HP:0000679)2.59796699
48Abnormality of permanent molar morphology (HP:0011071)2.59796699
49Partial duplication of thumb phalanx (HP:0009944)2.53787046
50Aplasia/hypoplasia of the uterus (HP:0008684)2.52570804
51Flat acetabular roof (HP:0003180)2.50792780
52Abnormality of renin-angiotensin system (HP:0000847)2.50320001
53Hypoplasia of dental enamel (HP:0006297)2.50208924
54Decreased circulating renin level (HP:0003351)2.44654062
55Hypoplasia of the uterus (HP:0000013)2.44634683
56Dehydration (HP:0001944)2.43434022
57Hypohidrosis (HP:0000966)2.42219454
58Thick nail (HP:0001805)2.42010536
59Cheilitis (HP:0100825)2.41562844
60Abnormality of cells of the erythroid lineage (HP:0012130)2.39922361
61Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.39420702
62Renal salt wasting (HP:0000127)2.37137924
63Natal tooth (HP:0000695)2.35553174
64Abnormality of molar (HP:0011077)2.34908411
65Abnormality of molar morphology (HP:0011070)2.34908411
66Abnormality of the dental pulp (HP:0006479)2.30423832
67Nasolacrimal duct obstruction (HP:0000579)2.28815557
68Testicular atrophy (HP:0000029)2.28576905
69Abnormality of the axillary hair (HP:0100134)2.27410579
70Abnormality of secondary sexual hair (HP:0009888)2.27410579
71Preauricular pit (HP:0004467)2.26987823
72Periauricular skin pits (HP:0100277)2.26987823
73Rib fusion (HP:0000902)2.23633049
74Erythroderma (HP:0001019)2.22886420
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22658998
76Congenital, generalized hypertrichosis (HP:0004540)2.21853191
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.18766822
78Hypoplasia of the fovea (HP:0007750)2.18766822
79Hepatoblastoma (HP:0002884)2.17475224
80Abnormal hair laboratory examination (HP:0003328)2.15295437
81Hyperkalemia (HP:0002153)2.14949182
82Abnormality of the gastric mucosa (HP:0004295)2.13043388
83Hyperphosphatemia (HP:0002905)2.12876494
84Blepharitis (HP:0000498)2.12493355
85Vascular calcification (HP:0004934)2.12361216
86Acanthosis nigricans (HP:0000956)2.12134586
87Partial duplication of the phalanx of hand (HP:0009999)2.08756303
88Intrahepatic cholestasis (HP:0001406)2.07119675
89Oligodontia (HP:0000677)2.06435165
90Concave nail (HP:0001598)2.06394695
91Symphalangism affecting the phalanges of the hand (HP:0009773)2.05905071
92Abnormality of chloride homeostasis (HP:0011422)2.04286621
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03838306
94Chronic bronchitis (HP:0004469)2.03332259
95Hyperaldosteronism (HP:0000859)2.03276352
96Malnutrition (HP:0004395)2.02471650
97Ectropion (HP:0000656)2.01587771
98Sparse lateral eyebrow (HP:0005338)1.99418944
99Absent hair (HP:0002298)1.99018848
100Advanced eruption of teeth (HP:0006288)1.96872795
101Abdominal distention (HP:0003270)1.95901448
102Distal lower limb muscle weakness (HP:0009053)1.95676488
103Abnormal cartilage morphology (HP:0002763)1.95291417
104Hyperparathyroidism (HP:0000843)1.95121444
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94578876
106Upper limb muscle weakness (HP:0003484)1.94577998
107Abnormal number of erythroid precursors (HP:0012131)1.93989901
108Seborrheic dermatitis (HP:0001051)1.93498000
109Hamartoma of the eye (HP:0010568)1.92903739
110Breast carcinoma (HP:0003002)1.91599821
111Septate vagina (HP:0001153)1.90722540
112Hyponatremia (HP:0002902)1.90682992
113Ridged nail (HP:0001807)1.88457609
114Abnormality of the lacrimal duct (HP:0011481)1.87951886
115Stenosis of the external auditory canal (HP:0000402)1.87796842
116Hypoplastic scapulae (HP:0000882)1.87735548
117Aplasia/Hypoplasia of the scapulae (HP:0006713)1.87735548
118Down-sloping shoulders (HP:0200021)1.87466277
119Germ cell neoplasia (HP:0100728)1.87448108
120Facial cleft (HP:0002006)1.84494234
121Selective tooth agenesis (HP:0001592)1.84275416
122Symptomatic seizures (HP:0011145)1.83821835
123Gout (HP:0001997)1.83698915
124Fused cervical vertebrae (HP:0002949)1.82869929
125Ventricular fibrillation (HP:0001663)1.82473421
126Pruritus (HP:0000989)1.82342849
127Unilateral renal agenesis (HP:0000122)1.82245851
128Palmoplantar keratoderma (HP:0000982)1.81913571
129Premature loss of primary teeth (HP:0006323)1.81089372
130Pterygium (HP:0001059)1.80571712
131Micronodular cirrhosis (HP:0001413)1.79873471
132Labial hypoplasia (HP:0000066)1.79833930
133Reticulocytopenia (HP:0001896)1.79789909
134Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77998729
135Fat malabsorption (HP:0002630)1.77390622
136Hypokinesia (HP:0002375)1.72839004
137Furrowed tongue (HP:0000221)1.70528682
138Abnormality of placental membranes (HP:0011409)1.68033273
139Amniotic constriction ring (HP:0009775)1.68033273
140Renal tubular acidosis (HP:0001947)1.67603289
141Cardiovascular calcification (HP:0011915)1.65779428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.34089430
2EPHA23.73648597
3MST43.69375016
4MST1R3.55396135
5MAP3K33.41465255
6CDK123.13707321
7MAP3K22.87491164
8TRIB32.86735974
9GRK52.66958398
10RIPK12.66907868
11MAP3K122.48829415
12MAPK152.37093287
13GRK12.34686691
14FRK2.22915392
15MAPKAPK32.22020613
16PBK2.13336820
17SIK12.06993245
18MAP2K22.01678664
19RPS6KB21.98737280
20STK391.91831025
21SMG11.86874992
22EPHB21.84974215
23STK101.75009577
24FER1.74792965
25GRK61.74609786
26TESK11.73479124
27PKN21.71336796
28HIPK21.69015585
29PIM21.66226867
30TGFBR21.59618504
31MAP2K61.55048297
32MATK1.53446574
33INSRR1.52260133
34ADRBK21.47935689
35ERBB31.45673739
36TAOK11.45629332
37PRKCI1.44588513
38MET1.41732137
39GRK71.40186347
40LATS11.40116867
41EIF2AK11.38530070
42MAP3K91.37214344
43PIK3CA1.21180230
44IRAK31.21007778
45PIK3CG1.19750739
46MAP3K111.19568537
47SCYL21.16321968
48VRK21.15116106
49PRKG21.13781165
50AKT31.12100625
51TTK1.09156157
52TRPM71.02377974
53STK38L1.02223427
54FGFR41.01409630
55MUSK0.98353202
56DYRK1B0.97803619
57PASK0.95000394
58LMTK20.94833715
59NME10.94279500
60MAPK70.93895650
61PTK20.93777285
62NEK60.92627214
63OXSR10.91142469
64SIK30.90030187
65ILK0.89541332
66TYRO30.88624020
67PTK60.84651197
68STK240.80990345
69WNK40.80427099
70EPHB10.79593152
71WNK10.78151292
72MAP3K10.78122413
73LRRK20.77763446
74EEF2K0.74576350
75MYLK0.70250602
76MOS0.68326596
77ERBB20.65288460
78TSSK60.65191428
79ADRBK10.64158455
80MAPKAPK20.61817259
81LATS20.61428723
82DMPK0.61247289
83FGFR30.61112371
84TRIM280.58270289
85ACVR1B0.56250471
86EIF2AK30.55025948
87NTRK10.54204164
88BRAF0.53509370
89STK30.53206706
90LIMK10.53174228
91DDR20.52841207
92PAK30.52093705
93MAP3K70.51586869
94BCKDK0.51322265
95MAP2K30.50479985
96CSK0.50221135
97MAP2K10.48380773
98STK160.48371788
99PAK40.45840537
100DAPK10.45700487
101TAOK20.44385822
102EPHA30.43802449
103FGFR20.41282444
104NUAK10.41001058
105ITK0.40471894
106FGFR10.40255250
107ARAF0.40179991
108MTOR0.39728551
109TAF10.39102064
110RPS6KA40.38786684
111CAMK2G0.38751675
112CHUK0.37821422
113TESK20.36579787
114GSK3A0.36425500
115CDK70.35709968
116CAMK2D0.35663145
117DYRK30.35231862
118AURKB0.35085322
119ICK0.34985859
120BCR0.34643406
121NME20.34040272
122MARK20.33935148
123STK380.33357535
124CSF1R0.33275607
125AKT20.33013322
126EIF2AK20.30587391
127CAMK40.29714261
128IKBKB0.28145878
129BRSK20.28126573
130IRAK10.27805473
131ABL20.27330149
132NEK10.25391339
133NLK0.24077972
134CSNK1E0.22861976
135CDC42BPA0.22836050
136AURKA0.22688781
137BMPR1B0.22327288
138CDK60.21473500
139MAPKAPK50.21311528
140CSNK1A10.20252650
141PDPK10.19408513
142PRKCE0.18710208
143CDK30.18550968
144TGFBR10.18363567
145IGF1R0.18238184
146MAP3K60.17834444
147RPS6KA10.17762114
148PRKAA20.17743084
149PRKD10.17673020
150CDK90.17212900
151YES10.16803584
152BMX0.16757258
153MAP3K80.16374655
154PRKCD0.15922507

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.70514065
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.60132658
3Sulfur metabolism_Homo sapiens_hsa009203.40132395
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.34490255
5Linoleic acid metabolism_Homo sapiens_hsa005913.32784181
6Arachidonic acid metabolism_Homo sapiens_hsa005903.27566830
7Ribosome_Homo sapiens_hsa030103.25285944
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.24037163
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.74566734
10Chemical carcinogenesis_Homo sapiens_hsa052042.64520993
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.63624749
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.40546568
13Vitamin digestion and absorption_Homo sapiens_hsa049772.26914305
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.22638017
15Sphingolipid metabolism_Homo sapiens_hsa006002.18089597
16Protein export_Homo sapiens_hsa030602.01975632
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.96351489
18Proteasome_Homo sapiens_hsa030501.91240110
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85531123
20Tight junction_Homo sapiens_hsa045301.71666547
21Arginine biosynthesis_Homo sapiens_hsa002201.68945319
22Fat digestion and absorption_Homo sapiens_hsa049751.66637860
23Fructose and mannose metabolism_Homo sapiens_hsa000511.66473471
24Retinol metabolism_Homo sapiens_hsa008301.63891574
25Histidine metabolism_Homo sapiens_hsa003401.63734386
26Glutathione metabolism_Homo sapiens_hsa004801.62683001
27Galactose metabolism_Homo sapiens_hsa000521.55674522
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55075857
29Folate biosynthesis_Homo sapiens_hsa007901.48159417
30Thyroid cancer_Homo sapiens_hsa052161.42657041
31Mineral absorption_Homo sapiens_hsa049781.42278737
32Basal cell carcinoma_Homo sapiens_hsa052171.39826470
33Ether lipid metabolism_Homo sapiens_hsa005651.38710800
34Bladder cancer_Homo sapiens_hsa052191.37374845
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36631320
36Phenylalanine metabolism_Homo sapiens_hsa003601.35842240
37Adherens junction_Homo sapiens_hsa045201.35479510
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23252338
39Arginine and proline metabolism_Homo sapiens_hsa003301.22479128
40Pancreatic secretion_Homo sapiens_hsa049721.21538461
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15026426
42Other glycan degradation_Homo sapiens_hsa005111.09888855
43Protein digestion and absorption_Homo sapiens_hsa049741.08907781
44Pentose phosphate pathway_Homo sapiens_hsa000301.04371907
45Hippo signaling pathway_Homo sapiens_hsa043901.01262552
46Tyrosine metabolism_Homo sapiens_hsa003501.00363799
47Vibrio cholerae infection_Homo sapiens_hsa051100.96471434
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.92427729
49N-Glycan biosynthesis_Homo sapiens_hsa005100.88857243
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.88763229
51Hepatitis C_Homo sapiens_hsa051600.88227086
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84809534
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84512537
54Pyruvate metabolism_Homo sapiens_hsa006200.83534248
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79788530
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78692022
57Carbon metabolism_Homo sapiens_hsa012000.77015492
58Biosynthesis of amino acids_Homo sapiens_hsa012300.76825422
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73516160
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72077502
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71149695
62PPAR signaling pathway_Homo sapiens_hsa033200.70790933
63Sulfur relay system_Homo sapiens_hsa041220.69369713
64Hedgehog signaling pathway_Homo sapiens_hsa043400.69243958
65ABC transporters_Homo sapiens_hsa020100.69212416
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69110764
67Fatty acid metabolism_Homo sapiens_hsa012120.66916599
68p53 signaling pathway_Homo sapiens_hsa041150.66855910
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65154607
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63947344
71Starch and sucrose metabolism_Homo sapiens_hsa005000.60354069
72Peroxisome_Homo sapiens_hsa041460.60057295
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58643914
74Endometrial cancer_Homo sapiens_hsa052130.56286597
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55644569
76Bile secretion_Homo sapiens_hsa049760.54101444
77ECM-receptor interaction_Homo sapiens_hsa045120.52397517
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.50910245
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50345119
80VEGF signaling pathway_Homo sapiens_hsa043700.49150624
81Insulin resistance_Homo sapiens_hsa049310.48719661
82Collecting duct acid secretion_Homo sapiens_hsa049660.47946698
83Glucagon signaling pathway_Homo sapiens_hsa049220.46985297
84Fatty acid elongation_Homo sapiens_hsa000620.46876993
85Steroid biosynthesis_Homo sapiens_hsa001000.46642347
86Vitamin B6 metabolism_Homo sapiens_hsa007500.45756653
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43764391
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.42542831
89beta-Alanine metabolism_Homo sapiens_hsa004100.42514023
90Insulin signaling pathway_Homo sapiens_hsa049100.42422150
91Proteoglycans in cancer_Homo sapiens_hsa052050.40931782
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.40853599
93AMPK signaling pathway_Homo sapiens_hsa041520.40763628
94Pathways in cancer_Homo sapiens_hsa052000.40039689
95Tryptophan metabolism_Homo sapiens_hsa003800.39809925
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.39513640
97Lysosome_Homo sapiens_hsa041420.39122174
98Nitrogen metabolism_Homo sapiens_hsa009100.37377715
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36561058
100Circadian rhythm_Homo sapiens_hsa047100.34859682
101Toxoplasmosis_Homo sapiens_hsa051450.34502909
102Huntingtons disease_Homo sapiens_hsa050160.33728721
103Taste transduction_Homo sapiens_hsa047420.33527835
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33043574
105Fatty acid biosynthesis_Homo sapiens_hsa000610.32880363
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32704198
107Notch signaling pathway_Homo sapiens_hsa043300.32658096
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32500165
109Propanoate metabolism_Homo sapiens_hsa006400.32385976
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32361478
111TGF-beta signaling pathway_Homo sapiens_hsa043500.31437318
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30863971
113Renin-angiotensin system_Homo sapiens_hsa046140.30703462
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.30631076
115Serotonergic synapse_Homo sapiens_hsa047260.30274376
116Wnt signaling pathway_Homo sapiens_hsa043100.30047839
117Insulin secretion_Homo sapiens_hsa049110.28470283
118MicroRNAs in cancer_Homo sapiens_hsa052060.27789099
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.27544427
120Oxidative phosphorylation_Homo sapiens_hsa001900.27384560
121Metabolic pathways_Homo sapiens_hsa011000.26911730
122Small cell lung cancer_Homo sapiens_hsa052220.26852706
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.26724803
124Glycerolipid metabolism_Homo sapiens_hsa005610.26566395
125Fatty acid degradation_Homo sapiens_hsa000710.24932064
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24198838
127Ovarian steroidogenesis_Homo sapiens_hsa049130.23586553
128Acute myeloid leukemia_Homo sapiens_hsa052210.22392042
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21960440
130Melanogenesis_Homo sapiens_hsa049160.21853390
131Inositol phosphate metabolism_Homo sapiens_hsa005620.21194513
132Legionellosis_Homo sapiens_hsa051340.21008816
133GnRH signaling pathway_Homo sapiens_hsa049120.20985557
134Ras signaling pathway_Homo sapiens_hsa040140.19243021
135Prostate cancer_Homo sapiens_hsa052150.16785259
136Apoptosis_Homo sapiens_hsa042100.16561162
137Caffeine metabolism_Homo sapiens_hsa002320.15533207
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15479922

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