RAB26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.26153151
2GDP-mannose metabolic process (GO:0019673)6.11324424
3cellular response to ATP (GO:0071318)5.66149710
4synaptic vesicle exocytosis (GO:0016079)5.62849309
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.53578650
6glutamate secretion (GO:0014047)5.36847753
7vocalization behavior (GO:0071625)5.32289284
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28839199
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.21786904
10rRNA methylation (GO:0031167)5.13875516
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13073707
12synaptic vesicle maturation (GO:0016188)5.11388590
13regulation of glutamate receptor signaling pathway (GO:1900449)4.95447140
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.93962225
15protein localization to synapse (GO:0035418)4.86699226
16synaptic transmission, glutamatergic (GO:0035249)4.80244183
17glutamate receptor signaling pathway (GO:0007215)4.77737910
18neuron-neuron synaptic transmission (GO:0007270)4.77203954
19locomotory exploration behavior (GO:0035641)4.76988513
20regulation of synaptic vesicle exocytosis (GO:2000300)4.65649342
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.64664022
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.52778016
23neuron cell-cell adhesion (GO:0007158)4.48230952
24urinary tract smooth muscle contraction (GO:0014848)4.40923940
25regulation of neuronal synaptic plasticity (GO:0048168)4.40846507
26cornea development in camera-type eye (GO:0061303)4.39717332
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.38290908
28behavioral response to cocaine (GO:0048148)4.34834244
29peristalsis (GO:0030432)4.32692870
30neuronal action potential propagation (GO:0019227)4.30396780
31rRNA modification (GO:0000154)4.30294596
32meiotic chromosome segregation (GO:0045132)4.30085467
33regulation of synaptic vesicle transport (GO:1902803)4.29354182
34neurotransmitter secretion (GO:0007269)4.27105794
35exploration behavior (GO:0035640)4.24706497
36regulation of excitatory postsynaptic membrane potential (GO:0060079)4.24105008
37response to histamine (GO:0034776)4.18366510
38synaptic vesicle endocytosis (GO:0048488)4.14510565
39negative regulation of cell aging (GO:0090344)4.12671620
40behavioral defense response (GO:0002209)4.11092171
41behavioral fear response (GO:0001662)4.11092171
42regulation of synapse structural plasticity (GO:0051823)4.11036460
43gamma-aminobutyric acid signaling pathway (GO:0007214)4.08423820
44regulation of postsynaptic membrane potential (GO:0060078)4.07565044
45adenine nucleotide transport (GO:0051503)4.06404440
46neuromuscular synaptic transmission (GO:0007274)4.02044536
47synaptic transmission, dopaminergic (GO:0001963)3.98932460
48keratinocyte development (GO:0003334)3.97852075
49positive regulation of neurotransmitter secretion (GO:0001956)3.97584276
50regulation of glutamate secretion (GO:0014048)3.91202337
51long-term synaptic potentiation (GO:0060291)3.88496844
52regulation of skeletal muscle contraction (GO:0014819)3.86995992
53long-term memory (GO:0007616)3.83193808
54regulation of synaptic plasticity (GO:0048167)3.80824129
55neuron recognition (GO:0008038)3.79689247
56fear response (GO:0042596)3.79084206
57DNA strand renaturation (GO:0000733)3.78993753
58positive regulation of membrane potential (GO:0045838)3.73252076
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72585891
60adenosine receptor signaling pathway (GO:0001973)3.72210013
61dendritic spine morphogenesis (GO:0060997)3.72172702
62behavioral response to nicotine (GO:0035095)3.71490583
63positive regulation of neurotransmitter transport (GO:0051590)3.71228129
64proline transport (GO:0015824)3.70497877
65sensory perception of taste (GO:0050909)3.67194824
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.65860477
67transmission of nerve impulse (GO:0019226)3.65385203
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64093581
69neurotransmitter transport (GO:0006836)3.63321710
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60072785
71neurotransmitter-gated ion channel clustering (GO:0072578)3.58116491
72serotonin metabolic process (GO:0042428)3.56327129
73regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.55747091
74regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.55747091
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52688990
76positive regulation of protein kinase C signaling (GO:0090037)3.49415726
77regulation of vesicle fusion (GO:0031338)3.48997432
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.48246291
79regulation of dendritic spine morphogenesis (GO:0061001)3.46456497
80positive regulation of synapse maturation (GO:0090129)3.46276206
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.46138287
82cell migration in hindbrain (GO:0021535)3.45648572
83regulation of neurotransmitter levels (GO:0001505)3.45456214
84neuromuscular process controlling posture (GO:0050884)3.44504706
85purine nucleotide transport (GO:0015865)3.39225364
86dendritic spine organization (GO:0097061)3.38525138
87regulation of neurotransmitter secretion (GO:0046928)3.30144256
88regulation of catecholamine metabolic process (GO:0042069)3.29973527
89regulation of dopamine metabolic process (GO:0042053)3.29973527
90purine ribonucleotide transport (GO:0015868)3.28970238
91long term synaptic depression (GO:0060292)3.25889622
92axonal fasciculation (GO:0007413)3.25090007
93membrane depolarization (GO:0051899)3.24077361
94presynaptic membrane assembly (GO:0097105)3.22329218
95positive regulation of dendritic spine development (GO:0060999)3.19729930
96learning (GO:0007612)3.19560049
97regulation of neurotransmitter uptake (GO:0051580)3.17182657
98detection of calcium ion (GO:0005513)3.17127976
99prepulse inhibition (GO:0060134)3.16642221
100regulation of synaptic transmission, dopaminergic (GO:0032225)3.15342416
101regulation of nuclear cell cycle DNA replication (GO:0033262)3.14785520
102DNA replication checkpoint (GO:0000076)3.14612871
103nucleoside transmembrane transport (GO:1901642)3.14323725
104regulation of neurotransmitter transport (GO:0051588)3.13388755
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.13110067
106ATP hydrolysis coupled proton transport (GO:0015991)3.13110067
107response to ATP (GO:0033198)3.12814759
108chemosensory behavior (GO:0007635)3.11727703
109regulation of synapse maturation (GO:0090128)3.11492913
110negative regulation of amino acid transport (GO:0051956)3.11301111
111purinergic nucleotide receptor signaling pathway (GO:0035590)3.10145076
112positive regulation of dendritic spine morphogenesis (GO:0061003)3.09936854
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09930288
114embryonic body morphogenesis (GO:0010172)3.09635644
115protein import into peroxisome matrix (GO:0016558)3.09318438
116response to amphetamine (GO:0001975)3.09182898
117postsynaptic membrane organization (GO:0001941)3.08641002
118synaptic transmission (GO:0007268)3.07700488
119iron coordination entity transport (GO:1901678)3.07322435
120regulation of dendritic spine development (GO:0060998)3.06740732
121layer formation in cerebral cortex (GO:0021819)3.05206947
122innervation (GO:0060384)3.04643094
123female mating behavior (GO:0060180)3.04051834
124regulation of synaptic transmission (GO:0050804)3.04042393
125gamma-aminobutyric acid transport (GO:0015812)3.03862620
126righting reflex (GO:0060013)3.03635141
127dopamine transport (GO:0015872)3.03137960
128positive regulation of synaptic transmission (GO:0050806)3.02550747
129membrane hyperpolarization (GO:0060081)3.02506709
130regulation of protein kinase A signaling (GO:0010738)3.01898950
131regulation of female receptivity (GO:0045924)3.01737701
132cellular potassium ion homeostasis (GO:0030007)3.01731547
133cranial nerve development (GO:0021545)2.99893260
134detection of light stimulus involved in visual perception (GO:0050908)2.99789047
135detection of light stimulus involved in sensory perception (GO:0050962)2.99789047
136body morphogenesis (GO:0010171)2.98251932
137nucleotide transmembrane transport (GO:1901679)2.97245584
138positive regulation of odontogenesis (GO:0042482)2.96644218
1393-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.91350423
140purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.91350423
141sex determination (GO:0007530)2.90585818
142melanin biosynthetic process (GO:0042438)2.87097626
143axon ensheathment in central nervous system (GO:0032291)2.86361561
144central nervous system myelination (GO:0022010)2.86361561
145sympathetic nervous system development (GO:0048485)2.75618150
146phosphate ion transmembrane transport (GO:0035435)2.74283258
147respiratory chain complex IV assembly (GO:0008535)2.72763621
148regulation of respiratory gaseous exchange (GO:0043576)2.72603564
149water-soluble vitamin biosynthetic process (GO:0042364)2.71855164
150lens fiber cell differentiation (GO:0070306)2.65775224
151sialylation (GO:0097503)2.64701035
152nucleotide-sugar biosynthetic process (GO:0009226)2.63065210
153negative regulation of gluconeogenesis (GO:0045721)2.60020155
154phosphatidylglycerol biosynthetic process (GO:0006655)2.58183014
155activation of adenylate cyclase activity (GO:0007190)2.54451999
156tRNA modification (GO:0006400)2.51216655
157mitotic cell cycle arrest (GO:0071850)2.50463805
158ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.47063276
159nucleoside bisphosphate biosynthetic process (GO:0033866)2.47063276
160purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.47063276
161melanin metabolic process (GO:0006582)2.45938579
162negative regulation of hormone biosynthetic process (GO:0032353)2.44939294
163inositol phosphate catabolic process (GO:0071545)2.43053808
164dicarboxylic acid transport (GO:0006835)2.42613928
165heme transport (GO:0015886)2.41767921
166cellular anion homeostasis (GO:0030002)2.41762918
167positive regulation of catecholamine secretion (GO:0033605)2.39060318
168response to gravity (GO:0009629)2.37957287
169phosphorylated carbohydrate dephosphorylation (GO:0046838)2.37846767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45136673
2GBX2_23144817_ChIP-Seq_PC3_Human3.87331603
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27499345
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16338294
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15680694
6RARB_27405468_Chip-Seq_BRAIN_Mouse3.13227026
7REST_21632747_ChIP-Seq_MESCs_Mouse3.13154833
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08814363
9* VDR_21846776_ChIP-Seq_THP-1_Human2.98491424
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.88528894
11LXR_22292898_ChIP-Seq_THP-1_Human2.82046774
12* P68_20966046_ChIP-Seq_HELA_Human2.80170332
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75345561
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74385982
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64024571
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64024571
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.61976260
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.61191147
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54723113
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53516903
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50559287
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45939199
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.43331892
24DROSHA_22980978_ChIP-Seq_HELA_Human2.43152079
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41896069
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34989064
27TAF15_26573619_Chip-Seq_HEK293_Human2.25576501
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23083869
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.21626139
30MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.21040990
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.19491653
32* RACK7_27058665_Chip-Seq_MCF-7_Human2.19348472
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.13089834
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11561275
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.10764550
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09517342
37STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04572434
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01059003
39SMC4_20622854_ChIP-Seq_HELA_Human2.00699594
40E2F1_20622854_ChIP-Seq_HELA_Human1.98917116
41* XRN2_22483619_ChIP-Seq_HELA_Human1.98264425
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95650463
43CREB1_26743006_Chip-Seq_LNCaP_Human1.95230759
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95204030
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.93697021
46* BCOR_27268052_Chip-Seq_Bcells_Human1.87496099
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.85331391
48* PHF8_20622854_ChIP-Seq_HELA_Human1.82727705
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.79333437
50CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.78812749
51* FOXP1_21924763_ChIP-Seq_HESCs_Human1.76703284
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74687031
53* BCL6_27268052_Chip-Seq_Bcells_Human1.74380042
54SMAD4_21799915_ChIP-Seq_A2780_Human1.74212673
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73048183
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69852524
57* RARB_24833708_ChIP-Seq_LIVER_Mouse1.68969571
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68802292
59AR_21572438_ChIP-Seq_LNCaP_Human1.68095566
60ZNF274_21170338_ChIP-Seq_K562_Hela1.67130109
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66420125
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66103157
63KDM2B_26808549_Chip-Seq_DND41_Human1.63023596
64MAF_26560356_Chip-Seq_TH2_Human1.62411612
65* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.60875405
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58433657
67KDM2B_26808549_Chip-Seq_K562_Human1.58114218
68P300_19829295_ChIP-Seq_ESCs_Human1.55499391
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53933278
70RARA_24833708_ChIP-Seq_LIVER_Mouse1.53521974
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.51265851
72* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50296817
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47937938
74* ELF1_20517297_ChIP-Seq_JURKAT_Human1.46643489
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46211129
76* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.45355392
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44461512
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43853883
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42738749
80CTCF_20526341_ChIP-Seq_ESCs_Human1.42122605
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41895568
82* ERA_21632823_ChIP-Seq_H3396_Human1.38354261
83* ESR2_21235772_ChIP-Seq_MCF-7_Human1.35527032
84* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.33937277
85FUS_26573619_Chip-Seq_HEK293_Human1.33202366
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.32645553
87CTCF_21964334_Chip-Seq_Bcells_Human1.32488214
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31953147
89SA1_27219007_Chip-Seq_Bcells_Human1.31521549
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29967776
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29860406
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29193074
93CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26931620
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26313219
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26156097
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.25283951
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24866772
98AR_25329375_ChIP-Seq_VCAP_Human1.24497475
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24467235
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24253158
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.23939784
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23409204
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23340125
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22842545
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21767020
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.21453363
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19459459
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19365879
109SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.19141827
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18514240
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16516918
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15570146
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14854020
114OCT4_19829295_ChIP-Seq_ESCs_Human1.14385217
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13408405
116AR_19668381_ChIP-Seq_PC3_Human1.13128653
117JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13009868
118ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12819099
119POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11558202
120STAT3_23295773_ChIP-Seq_U87_Human1.10275918
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.10234855
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.09526773
123FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09140300
124TP53_22127205_ChIP-Seq_IMR90_Human1.08866452
125EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08523229
126P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08253955
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08142969
128VDR_22108803_ChIP-Seq_LS180_Human1.08053514
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07843370
130* ETS1_21867929_ChIP-Seq_TH2_Mouse1.07241985
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07077816
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06129429
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.04726592
134* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04307195
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03505623
136TCF4_23295773_ChIP-Seq_U87_Human1.02489520
137ATF3_27146783_Chip-Seq_COLON_Human1.01989520
138* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01911793
139JUN_21703547_ChIP-Seq_K562_Human1.01821645
140MYC_22102868_ChIP-Seq_BL_Human1.01586658
141IGF1R_20145208_ChIP-Seq_DFB_Human1.01206247
142VDR_24763502_ChIP-Seq_THP-1_Human1.00571616
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.99606132
144RNF2_27304074_Chip-Seq_NSC_Mouse0.98315714
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97322263
146RUNX2_22187159_ChIP-Seq_PCA_Human0.95377258
147RING1B_27294783_Chip-Seq_NPCs_Mouse0.94972824
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93363748
149* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92255550
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91922306
151YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90878911
152CTCF_27219007_Chip-Seq_Bcells_Human0.90174032
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89995278
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.88635397
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.88440298
156MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88042382
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87488201
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87071837
159TP53_16413492_ChIP-PET_HCT116_Human0.86571877
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.84118320
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83627858
162SOX9_26525672_Chip-Seq_HEART_Mouse0.83252172
163AHR_22903824_ChIP-Seq_MCF-7_Human0.82303870
164SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80309797
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79106063
166* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79078353
167TET1_21490601_ChIP-Seq_MESCs_Mouse0.79039387
168FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78800028
169POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77825071
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77825071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.74132975
2MP0003880_abnormal_central_pattern5.76141625
3MP0001986_abnormal_taste_sensitivity4.64401158
4MP0003635_abnormal_synaptic_transmissio4.29343918
5MP0003136_yellow_coat_color3.82067742
6MP0009745_abnormal_behavioral_response3.72551812
7MP0005174_abnormal_tail_pigmentation3.66219044
8MP0002063_abnormal_learning/memory/cond3.56070564
9MP0005171_absent_coat_pigmentation3.52939994
10MP0002064_seizures3.33342616
11MP0001968_abnormal_touch/_nociception3.17829120
12MP0002572_abnormal_emotion/affect_behav3.06592705
13MP0004270_analgesia3.06574943
14MP0009046_muscle_twitch2.98695631
15MP0001501_abnormal_sleep_pattern2.94425430
16MP0002822_catalepsy2.83937481
17MP0002736_abnormal_nociception_after2.83472335
18MP0002272_abnormal_nervous_system2.64976390
19MP0001440_abnormal_grooming_behavior2.48941564
20MP0001486_abnormal_startle_reflex2.33436796
21MP0006276_abnormal_autonomic_nervous2.16812306
22MP0002638_abnormal_pupillary_reflex2.15843769
23MP0005423_abnormal_somatic_nervous2.15102116
24MP0002734_abnormal_mechanical_nocicepti2.14005186
25MP0001529_abnormal_vocalization2.00467114
26MP0002735_abnormal_chemical_nociception2.00077064
27MP0002067_abnormal_sensory_capabilities1.94345146
28MP0001756_abnormal_urination1.89907254
29MP0002733_abnormal_thermal_nociception1.85163284
30MP0001970_abnormal_pain_threshold1.84085324
31MP0000015_abnormal_ear_pigmentation1.81064204
32MP0001905_abnormal_dopamine_level1.80833463
33MP0004924_abnormal_behavior1.80225943
34MP0005386_behavior/neurological_phenoty1.80225943
35MP0003122_maternal_imprinting1.76086347
36MP0002557_abnormal_social/conspecific_i1.74750977
37MP0008875_abnormal_xenobiotic_pharmacok1.72953726
38MP0002184_abnormal_innervation1.72526691
39MP0000778_abnormal_nervous_system1.70752479
40MP0000538_abnormal_urinary_bladder1.65416373
41MP0003879_abnormal_hair_cell1.64588462
42MP0003329_amyloid_beta_deposits1.62410857
43MP0005645_abnormal_hypothalamus_physiol1.60702326
44MP0004811_abnormal_neuron_physiology1.60180905
45MP0000003_abnormal_adipose_tissue1.56257100
46MP0003787_abnormal_imprinting1.55789829
47MP0004043_abnormal_pH_regulation1.50541185
48MP0000955_abnormal_spinal_cord1.48475276
49MP0008569_lethality_at_weaning1.46576857
50MP0004142_abnormal_muscle_tone1.44624801
51MP0002066_abnormal_motor_capabilities/c1.40271297
52MP0002909_abnormal_adrenal_gland1.38762032
53MP0005646_abnormal_pituitary_gland1.38050234
54MP0005332_abnormal_amino_acid1.36320069
55MP0001984_abnormal_olfaction1.34650667
56MP0002882_abnormal_neuron_morphology1.28156871
57MP0005220_abnormal_exocrine_pancreas1.25669022
58MP0002160_abnormal_reproductive_system1.24623717
59MP0008872_abnormal_physiological_respon1.24603636
60MP0001664_abnormal_digestion1.24296857
61MP0004019_abnormal_vitamin_homeostasis1.23237020
62MP0004858_abnormal_nervous_system1.20537974
63MP0001502_abnormal_circadian_rhythm1.18473735
64MP0004130_abnormal_muscle_cell1.18153078
65MP0001765_abnormal_ion_homeostasis1.15393961
66MP0001188_hyperpigmentation1.13779070
67MP0001944_abnormal_pancreas_morphology1.13426091
68MP0009780_abnormal_chondrocyte_physiolo1.12049852
69MP0001661_extended_life_span1.10772917
70MP0005365_abnormal_bile_salt1.10536691
71MP0002876_abnormal_thyroid_physiology1.08358935
72MP0005535_abnormal_body_temperature1.08209719
73MP0004381_abnormal_hair_follicle1.06074704
74MP0002837_dystrophic_cardiac_calcinosis1.05051344
75MP0002069_abnormal_eating/drinking_beha1.04866186
76MP0003123_paternal_imprinting1.04637052
77MP0003633_abnormal_nervous_system1.03387920
78MP0005083_abnormal_biliary_tract1.03332449
79MP0002152_abnormal_brain_morphology1.03134114
80MP0004885_abnormal_endolymph1.00079046
81MP0008877_abnormal_DNA_methylation0.99073483
82MP0004145_abnormal_muscle_electrophysio0.98290299
83MP0008874_decreased_physiological_sensi0.98219435
84MP0010234_abnormal_vibrissa_follicle0.97091895
85MP0001348_abnormal_lacrimal_gland0.96178700
86MP0003631_nervous_system_phenotype0.91999149
87MP0003137_abnormal_impulse_conducting0.91810043
88MP0001666_abnormal_nutrient_absorption0.87137880
89MP0005499_abnormal_olfactory_system0.85757661
90MP0005394_taste/olfaction_phenotype0.85757661
91MP0005076_abnormal_cell_differentiation0.85587999
92MP0002229_neurodegeneration0.84057047
93MP0004133_heterotaxia0.82901708
94MP0001346_abnormal_lacrimal_gland0.81976287
95MP0000751_myopathy0.80414749
96MP0005584_abnormal_enzyme/coenzyme_acti0.75630600
97MP0010386_abnormal_urinary_bladder0.74554803
98MP0003693_abnormal_embryo_hatching0.73496201
99MP0002928_abnormal_bile_duct0.72382507
100MP0005084_abnormal_gallbladder_morpholo0.72260071
101MP0004085_abnormal_heartbeat0.72244823
102MP0001963_abnormal_hearing_physiology0.71939261
103MP0006292_abnormal_olfactory_placode0.71716891
104MP0003121_genomic_imprinting0.71575396
105MP0004233_abnormal_muscle_weight0.70897198
106MP0008961_abnormal_basal_metabolism0.70011357
107MP0003283_abnormal_digestive_organ0.68903425
108MP0005551_abnormal_eye_electrophysiolog0.67155608
109MP0002752_abnormal_somatic_nervous0.66156144
110MP0003111_abnormal_nucleus_morphology0.65580241
111MP0003172_abnormal_lysosome_physiology0.64935846
112MP0000013_abnormal_adipose_tissue0.64467408
113MP0000631_abnormal_neuroendocrine_gland0.64333031
114MP0004484_altered_response_of0.64310752
115MP0002653_abnormal_ependyma_morphology0.63999935
116MP0003632_abnormal_nervous_system0.63841780
117MP0006072_abnormal_retinal_apoptosis0.63494743
118MP0005253_abnormal_eye_physiology0.63162201
119MP0005448_abnormal_energy_balance0.62845339
120MP0002078_abnormal_glucose_homeostasis0.62274635
121MP0000604_amyloidosis0.62265123
122MP0000750_abnormal_muscle_regeneration0.60482959
123MP0004147_increased_porphyrin_level0.59649586
124MP0004742_abnormal_vestibular_system0.59367803
125MP0005409_darkened_coat_color0.59205840
126MP0005187_abnormal_penis_morphology0.58969319
127MP0003075_altered_response_to0.56663814
128MP0003956_abnormal_body_size0.55467527
129MP0000427_abnormal_hair_cycle0.54884428
130MP0000747_muscle_weakness0.53840952
131MP0003634_abnormal_glial_cell0.51591373
132MP0010769_abnormal_survival0.51252089
133MP0002082_postnatal_lethality0.50127811
134MP0010770_preweaning_lethality0.50127811
135MP0002693_abnormal_pancreas_physiology0.49963694
136MP0005379_endocrine/exocrine_gland_phen0.49739519
137MP0010768_mortality/aging0.49455668
138MP0003861_abnormal_nervous_system0.49026619
139MP0005623_abnormal_meninges_morphology0.48655995

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.30957274
2Myokymia (HP:0002411)6.46052489
3Visual hallucinations (HP:0002367)6.10486845
4Focal seizures (HP:0007359)5.87272676
5Testicular atrophy (HP:0000029)5.38212526
6Epileptic encephalopathy (HP:0200134)5.32710543
7Rib fusion (HP:0000902)5.15805781
8Atonic seizures (HP:0010819)4.98076545
9Akinesia (HP:0002304)4.86958786
10Febrile seizures (HP:0002373)4.55722337
11Absence seizures (HP:0002121)4.53674816
12Dialeptic seizures (HP:0011146)4.23119581
13Generalized tonic-clonic seizures (HP:0002069)4.17752057
14Hyperventilation (HP:0002883)4.10462583
15Intestinal fistula (HP:0100819)3.98961603
16Rectovaginal fistula (HP:0000143)3.94598279
17Rectal fistula (HP:0100590)3.94598279
18Progressive cerebellar ataxia (HP:0002073)3.76088743
19Vaginal fistula (HP:0004320)3.76056985
20Congenital stationary night blindness (HP:0007642)3.74066897
21Poikiloderma (HP:0001029)3.63992381
22Popliteal pterygium (HP:0009756)3.61555098
23Thin bony cortex (HP:0002753)3.55022151
24Attenuation of retinal blood vessels (HP:0007843)3.48422926
25Impaired vibration sensation in the lower limbs (HP:0002166)3.46471098
26Broad-based gait (HP:0002136)3.43492828
27Amblyopia (HP:0000646)3.42784323
28Turricephaly (HP:0000262)3.39809135
29Hyperinsulinemic hypoglycemia (HP:0000825)3.35006192
30Lip pit (HP:0100267)3.28535604
31Poor eye contact (HP:0000817)3.23115381
32Cerebral inclusion bodies (HP:0100314)3.20222118
33Aplasia of the musculature (HP:0100854)3.19329435
34Delusions (HP:0000746)3.12971776
35Anxiety (HP:0000739)3.08946885
36Facial hemangioma (HP:0000329)3.06947085
37Birth length less than 3rd percentile (HP:0003561)3.05822119
38Squamous cell carcinoma (HP:0002860)3.04092783
39Gaze-evoked nystagmus (HP:0000640)3.03703703
40Abnormality of the intrinsic pathway (HP:0010989)3.01088100
41Supranuclear gaze palsy (HP:0000605)3.00477068
42Epileptiform EEG discharges (HP:0011182)2.99113118
43Dysmetria (HP:0001310)2.96455876
44Bony spicule pigmentary retinopathy (HP:0007737)2.95657640
45Ulnar bowing (HP:0003031)2.95547721
46Abnormality of the nasal septum (HP:0000419)2.94458142
47Truncal ataxia (HP:0002078)2.92752284
48Dysdiadochokinesis (HP:0002075)2.89331996
49Diminished movement (HP:0002374)2.85449555
50Patellar aplasia (HP:0006443)2.83925442
51Abnormal eating behavior (HP:0100738)2.80664717
52Dyschromatopsia (HP:0007641)2.78163751
53EEG with generalized epileptiform discharges (HP:0011198)2.77378011
54Abnormal social behavior (HP:0012433)2.73814482
55Impaired social interactions (HP:0000735)2.73814482
56Depression (HP:0000716)2.73623099
57Ketoacidosis (HP:0001993)2.72978890
58Abnormality of the lower motor neuron (HP:0002366)2.71747069
59Polydipsia (HP:0001959)2.69791706
60Abnormal drinking behavior (HP:0030082)2.69791706
61Excessive salivation (HP:0003781)2.67305344
62Drooling (HP:0002307)2.67305344
63Aplasia/Hypoplasia of the patella (HP:0006498)2.65000364
64Premature graying of hair (HP:0002216)2.64161650
65Impaired smooth pursuit (HP:0007772)2.60554798
66Absent speech (HP:0001344)2.59233309
67Hypsarrhythmia (HP:0002521)2.58668945
68Coronal craniosynostosis (HP:0004440)2.58082141
69Hypoplasia of the pons (HP:0012110)2.57162548
70Bradykinesia (HP:0002067)2.55157338
71Urinary bladder sphincter dysfunction (HP:0002839)2.54996508
72Postural instability (HP:0002172)2.54846657
73Action tremor (HP:0002345)2.54373883
74Short chin (HP:0000331)2.54250144
75Hypoalbuminemia (HP:0003073)2.52240600
76Abnormal albumin level (HP:0012116)2.52240600
77Progressive inability to walk (HP:0002505)2.52215917
78Delayed epiphyseal ossification (HP:0002663)2.51599123
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.47114799
80Facial diplegia (HP:0001349)2.46064154
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45516867
82Status epilepticus (HP:0002133)2.45011312
83Prolonged partial thromboplastin time (HP:0003645)2.41178291
84Inability to walk (HP:0002540)2.40672030
85Polyphagia (HP:0002591)2.33120123
86Type II lissencephaly (HP:0007260)2.31578629
87Diplopia (HP:0000651)2.28360451
88Abnormality of binocular vision (HP:0011514)2.28360451
89Ankle clonus (HP:0011448)2.28163842
90Hemiparesis (HP:0001269)2.28129546
91Abnormality of the pons (HP:0007361)2.27113281
92Anteriorly placed anus (HP:0001545)2.25294502
93Urinary urgency (HP:0000012)2.25125665
94Generalized myoclonic seizures (HP:0002123)2.24612353
95Decreased circulating renin level (HP:0003351)2.24135908
96Abnormality of ocular smooth pursuit (HP:0000617)2.22954076
97Stereotypic behavior (HP:0000733)2.21781360
98Widely patent fontanelles and sutures (HP:0004492)2.20160905
99Homocystinuria (HP:0002156)2.20013589
100Abnormality of homocysteine metabolism (HP:0010919)2.20013589
101Fetal akinesia sequence (HP:0001989)2.19916092
102Scanning speech (HP:0002168)2.19782613
103Protruding tongue (HP:0010808)2.19752505
104Absent thumb (HP:0009777)2.17277942
105Spastic gait (HP:0002064)2.16503654
106Ketosis (HP:0001946)2.16295461
107Impaired vibratory sensation (HP:0002495)2.15989141
108Unsteady gait (HP:0002317)2.14641477
109Acute necrotizing encephalopathy (HP:0006965)2.13581231
110Neonatal onset (HP:0003623)2.13520531
111Increased circulating renin level (HP:0000848)2.11757383
112Chorioretinal atrophy (HP:0000533)2.11507429
113Absent/shortened dynein arms (HP:0200106)2.11405809
114Dynein arm defect of respiratory motile cilia (HP:0012255)2.11405809
115Annular pancreas (HP:0001734)2.08432157
116Atrioventricular block (HP:0001678)2.08360495
117Resting tremor (HP:0002322)2.07541174
118Shoulder girdle muscle weakness (HP:0003547)2.06583396
119Focal dystonia (HP:0004373)2.05419998
120Abnormal mitochondria in muscle tissue (HP:0008316)2.04392967
121Enlarged epiphyses (HP:0010580)2.01975003
122Male infertility (HP:0003251)2.01891649
123Neurofibrillary tangles (HP:0002185)2.01456641
124Abnormality of renin-angiotensin system (HP:0000847)2.01337702
125Generalized hypopigmentation of hair (HP:0011358)1.99250612
126Myotonia (HP:0002486)1.98360660
127Psychosis (HP:0000709)1.98073718
128Progressive microcephaly (HP:0000253)1.97936091
129Mutism (HP:0002300)1.97875482
130Morphological abnormality of the middle ear (HP:0008609)1.96313463
131Torticollis (HP:0000473)1.95961691
132Amniotic constriction ring (HP:0009775)1.95947139
133Abnormality of placental membranes (HP:0011409)1.95947139
134Hypoventilation (HP:0002791)1.95854056
135Incomplete penetrance (HP:0003829)1.95680968
136Failure to thrive in infancy (HP:0001531)1.94510715
137Short thumb (HP:0009778)1.94507550
138Limb dystonia (HP:0002451)1.94077756
139Progressive macrocephaly (HP:0004481)1.92685014
140Gait imbalance (HP:0002141)1.91280896
141Joint stiffness (HP:0001387)1.91051002
142Fair hair (HP:0002286)1.89580810
143Neonatal respiratory distress (HP:0002643)1.89310637
144Flat occiput (HP:0005469)1.88099553
145Polyuria (HP:0000103)1.87557324
146Dysmetric saccades (HP:0000641)1.86430429
147Genetic anticipation (HP:0003743)1.85711637
148Ventricular fibrillation (HP:0001663)1.85703884
149Termporal pattern (HP:0011008)1.85603622
150Insidious onset (HP:0003587)1.85603622
151Hyperthyroidism (HP:0000836)1.85239462
152Tubular atrophy (HP:0000092)1.83623118
153Rapidly progressive (HP:0003678)1.83556098
154Dysautonomia (HP:0002459)1.83309797
155Breast hypoplasia (HP:0003187)1.82681614
156Abnormality of polysaccharide metabolism (HP:0011012)1.82393603
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82393603
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82393603
159White forelock (HP:0002211)1.81816103
160Poor suck (HP:0002033)1.81620510
161Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81601623
162Abnormality of the costochondral junction (HP:0000919)1.80917301
163Pheochromocytoma (HP:0002666)1.80188366
164Gait ataxia (HP:0002066)1.80109935
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79200889
166Abnormal urine output (HP:0012590)1.77869508
167Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77349008
168Urinary glycosaminoglycan excretion (HP:0003541)1.77294827
169Mucopolysacchariduria (HP:0008155)1.77294827
170Athetosis (HP:0002305)1.77194414
171Increased number of teeth (HP:0011069)1.77111268
172Hypophosphatemic rickets (HP:0004912)1.77006174
173Abnormal hair whorl (HP:0010721)1.75600511
174Heart block (HP:0012722)1.75434871
175Congenital primary aphakia (HP:0007707)1.75222169
176Cerebellar dysplasia (HP:0007033)1.75089947
177Craniofacial dystonia (HP:0012179)1.74652403
178Lower limb muscle weakness (HP:0007340)1.74626602
179Retinal dysplasia (HP:0007973)1.74453975
180External ophthalmoplegia (HP:0000544)1.74235657
181Absent radius (HP:0003974)1.74162304
182Rigidity (HP:0002063)1.72417054
183Neuroendocrine neoplasm (HP:0100634)1.72278798
184Neuronal loss in central nervous system (HP:0002529)1.71647447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.98944061
2TLK14.95383822
3NTRK34.77129279
4WNK44.51103558
5ZAK4.31614121
6MAP3K94.06505866
7PDK23.94484448
8MAPK153.89078329
9MAP3K43.12450044
10RIPK42.72374706
11MAP2K72.60917656
12MAP3K122.57093649
13MINK12.54058623
14ARAF2.41288148
15PLK22.27865698
16DAPK22.18473214
17GRK52.14617727
18PNCK2.12491682
19DAPK12.06662774
20MAP3K132.00540891
21KSR11.99170054
22KSR21.93912468
23MAP2K41.91046304
24CASK1.90119001
25CDK191.89088393
26STK391.86187174
27STK161.79673406
28FRK1.75388906
29TRIB31.72190391
30PAK61.68544252
31TNIK1.68147116
32ACVR1B1.63475584
33SIK11.56126189
34MST1R1.55291404
35NTRK21.48023504
36PTK2B1.45754175
37MAP2K61.44553308
38CAMKK11.44330206
39CAMKK21.43106137
40PRPF4B1.41669408
41CDK51.40699600
42NME11.40415340
43MARK11.39469727
44FES1.35061224
45PIM21.31189798
46MUSK1.30972187
47PHKG21.30836907
48PHKG11.30836907
49SIK31.28457607
50TESK21.27424166
51FGR1.27318188
52GRK61.27189854
53SIK21.25313965
54PRKCG1.23134924
55ICK1.22624691
56CAMK2A1.21466158
57MAPK121.17705142
58BMPR1B1.17386690
59NTRK11.15764624
60BMPR21.14371821
61RAF11.14288473
62PRKD31.03618899
63EEF2K0.97668030
64IRAK20.96589081
65DYRK1A0.95753020
66STK380.94298414
67CAMK2B0.92705497
68WNK10.92539428
69CDK180.92144604
70MAPK110.90201649
71WNK30.89180810
72CAMK10.86974186
73BRAF0.86203358
74MAPK130.85287227
75CDK150.84403039
76UHMK10.82828505
77CDK140.82313610
78TYRO30.81360871
79AURKA0.78264484
80OXSR10.78080321
81RPS6KA20.75238113
82BLK0.74633241
83CDK11A0.74365603
84MAPKAPK30.73268438
85MOS0.72645976
86PRKD20.72122295
87PRKAA10.71133557
88PKN10.69660387
89PRKD10.69612180
90ADRBK20.69129263
91PKN20.68917664
92BCR0.64147453
93RPS6KA50.64121058
94SGK10.63517245
95CAMK1G0.62225696
96FGFR20.61430335
97FER0.61325485
98TNK20.61271606
99MAP3K110.61168256
100LATS20.59779574
101MET0.59475529
102MAPK80.57922308
103MAP3K60.57442645
104MTOR0.57008096
105PDK10.56336704
106STK110.55834023
107MAP3K20.55119267
108PINK10.53751082
109MAP2K10.53669793
110CAMK2D0.53631110
111GRK70.53408635
112PDPK10.52829704
113HIPK20.50817629
114PRKCI0.48075726
115ADRBK10.47782590
116GRK10.47551291
117AKT30.47518973
118PRKCH0.46929140
119DAPK30.46333633
120PRKCZ0.46211217
121ERN10.46001107
122PAK30.45493580
123TAOK10.45048282
124TSSK60.44266729
125CAMK2G0.43083897
126CSNK1D0.41146613
127RET0.40211313
128SGK4940.40003572
129SGK2230.40003572
130AKT20.39541718
131CSNK1G20.39411360
132MAP3K10.38307358
133NEK60.37637683
134RPS6KA30.37150369
135PLK30.36576453
136RIPK10.36493972
137INSRR0.36206330
138MAPK100.36073633
139BCKDK0.35301122
140CAMK40.34403290
141PRKCE0.33754019
142MARK20.30701430
143CSNK1E0.30154460
144PRKACA0.29352948
145CCNB10.29246670
146CSNK1A10.28971147
147PRKCB0.28151539
148PRKCA0.28114824

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.38218364
2Sulfur relay system_Homo sapiens_hsa041224.30599422
3Synaptic vesicle cycle_Homo sapiens_hsa047213.52655071
4Long-term potentiation_Homo sapiens_hsa047202.95997446
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85065005
6Amphetamine addiction_Homo sapiens_hsa050312.84656050
7GABAergic synapse_Homo sapiens_hsa047272.67595623
8Olfactory transduction_Homo sapiens_hsa047402.63996583
9Circadian entrainment_Homo sapiens_hsa047132.63391566
10Glutamatergic synapse_Homo sapiens_hsa047242.58781485
11Morphine addiction_Homo sapiens_hsa050322.57455605
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.51977707
13Collecting duct acid secretion_Homo sapiens_hsa049662.46551942
14Fructose and mannose metabolism_Homo sapiens_hsa000512.30938482
15Dopaminergic synapse_Homo sapiens_hsa047282.26171182
16Pancreatic secretion_Homo sapiens_hsa049722.24844469
17Salivary secretion_Homo sapiens_hsa049702.22005592
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08840858
19Taste transduction_Homo sapiens_hsa047422.06963997
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.97888089
21Calcium signaling pathway_Homo sapiens_hsa040201.91888189
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.91591957
23Insulin secretion_Homo sapiens_hsa049111.89066536
24Renin secretion_Homo sapiens_hsa049241.81267005
25Serotonergic synapse_Homo sapiens_hsa047261.81096217
26Cocaine addiction_Homo sapiens_hsa050301.80849265
27Gastric acid secretion_Homo sapiens_hsa049711.74222449
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69671589
29Vitamin B6 metabolism_Homo sapiens_hsa007501.67777537
30Oxidative phosphorylation_Homo sapiens_hsa001901.67503855
31Long-term depression_Homo sapiens_hsa047301.67201613
32Cholinergic synapse_Homo sapiens_hsa047251.65261939
33Vibrio cholerae infection_Homo sapiens_hsa051101.62810874
34Oxytocin signaling pathway_Homo sapiens_hsa049211.59870212
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54266855
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50472275
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40345326
38Alzheimers disease_Homo sapiens_hsa050101.35595539
39Arginine biosynthesis_Homo sapiens_hsa002201.35569250
40GnRH signaling pathway_Homo sapiens_hsa049121.35334454
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34664836
42Cardiac muscle contraction_Homo sapiens_hsa042601.29976189
43Parkinsons disease_Homo sapiens_hsa050121.29925826
44Gap junction_Homo sapiens_hsa045401.19715807
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19569494
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19473689
47cAMP signaling pathway_Homo sapiens_hsa040241.16769299
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16228104
49Sphingolipid metabolism_Homo sapiens_hsa006001.12422638
50Fanconi anemia pathway_Homo sapiens_hsa034601.09309466
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08758361
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07679080
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06115460
54Estrogen signaling pathway_Homo sapiens_hsa049151.00316577
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98938353
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98080490
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95552357
58Oocyte meiosis_Homo sapiens_hsa041140.94582873
59Melanogenesis_Homo sapiens_hsa049160.92957651
60Phototransduction_Homo sapiens_hsa047440.92085024
61Glioma_Homo sapiens_hsa052140.87338265
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86674064
63Huntingtons disease_Homo sapiens_hsa050160.85673055
64Bile secretion_Homo sapiens_hsa049760.84145306
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83596012
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.82527899
67Axon guidance_Homo sapiens_hsa043600.80415123
68ABC transporters_Homo sapiens_hsa020100.79170450
69Vitamin digestion and absorption_Homo sapiens_hsa049770.78284814
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77111092
71Hedgehog signaling pathway_Homo sapiens_hsa043400.76060909
72ErbB signaling pathway_Homo sapiens_hsa040120.75634125
73Type II diabetes mellitus_Homo sapiens_hsa049300.73545562
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72432411
75Phenylalanine metabolism_Homo sapiens_hsa003600.71294387
76Pyruvate metabolism_Homo sapiens_hsa006200.71078933
77Lysine degradation_Homo sapiens_hsa003100.66555668
78Ovarian steroidogenesis_Homo sapiens_hsa049130.66374706
79Protein digestion and absorption_Homo sapiens_hsa049740.62729584
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61633298
81VEGF signaling pathway_Homo sapiens_hsa043700.61552784
82Histidine metabolism_Homo sapiens_hsa003400.60496580
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59185293
84Choline metabolism in cancer_Homo sapiens_hsa052310.58397327
85Alcoholism_Homo sapiens_hsa050340.57937463
86Hippo signaling pathway_Homo sapiens_hsa043900.57372813
87Systemic lupus erythematosus_Homo sapiens_hsa053220.56640070
88Glucagon signaling pathway_Homo sapiens_hsa049220.56447029
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.55065643
90Thyroid hormone synthesis_Homo sapiens_hsa049180.55039717
91Type I diabetes mellitus_Homo sapiens_hsa049400.51731589
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51671402
93MAPK signaling pathway_Homo sapiens_hsa040100.51410955
94Mineral absorption_Homo sapiens_hsa049780.51181546
95Dorso-ventral axis formation_Homo sapiens_hsa043200.50318755
96Fatty acid metabolism_Homo sapiens_hsa012120.50174815
97AMPK signaling pathway_Homo sapiens_hsa041520.46887656
98beta-Alanine metabolism_Homo sapiens_hsa004100.46829838
99Other glycan degradation_Homo sapiens_hsa005110.46316477
100Fatty acid degradation_Homo sapiens_hsa000710.44531180
101Butanoate metabolism_Homo sapiens_hsa006500.44393381
102Glycerolipid metabolism_Homo sapiens_hsa005610.43762555
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.43207046
104Inositol phosphate metabolism_Homo sapiens_hsa005620.42640250
105RNA polymerase_Homo sapiens_hsa030200.42417299
106Dilated cardiomyopathy_Homo sapiens_hsa054140.42174154
107Rheumatoid arthritis_Homo sapiens_hsa053230.41970138
108African trypanosomiasis_Homo sapiens_hsa051430.41028847
109Nitrogen metabolism_Homo sapiens_hsa009100.40167490
110Arginine and proline metabolism_Homo sapiens_hsa003300.39977095
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.38982162
112Ras signaling pathway_Homo sapiens_hsa040140.38001966
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37867869
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35236445
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35208727
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34913486
117Insulin resistance_Homo sapiens_hsa049310.34838607
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33393610
119Metabolic pathways_Homo sapiens_hsa011000.33300702
120Rap1 signaling pathway_Homo sapiens_hsa040150.32333010
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32216027
122Prion diseases_Homo sapiens_hsa050200.30586548
123Fat digestion and absorption_Homo sapiens_hsa049750.29843734
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27103855
125mTOR signaling pathway_Homo sapiens_hsa041500.26810134
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26160977
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25273243
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.25161289
129Non-small cell lung cancer_Homo sapiens_hsa052230.23654165
130Circadian rhythm_Homo sapiens_hsa047100.23527629
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22708645
132Wnt signaling pathway_Homo sapiens_hsa043100.22458780
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.22296371
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21642895
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21237493
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.20798459
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19610894
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19398094
139Regulation of autophagy_Homo sapiens_hsa041400.18229176
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16533279
141Insulin signaling pathway_Homo sapiens_hsa049100.16270096

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