RAB27A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.61055856
2Golgi transport vesicle coating (GO:0048200)8.61055856
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.66886871
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.62517125
5sequestering of metal ion (GO:0051238)5.33652750
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.32054627
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.32054627
8protein maturation by protein folding (GO:0022417)5.18189914
9signal peptide processing (GO:0006465)5.18142033
10endocrine pancreas development (GO:0031018)5.11766750
11protein retention in ER lumen (GO:0006621)4.85719758
12positive regulation by symbiont of host defense response (GO:0052509)4.59087764
13modulation by symbiont of host defense response (GO:0052031)4.59087764
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.59087764
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.59087764
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.59087764
17modulation by symbiont of host immune response (GO:0052553)4.59087764
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.57329603
19type B pancreatic cell development (GO:0003323)4.51910315
20negative regulation of glycoprotein biosynthetic process (GO:0010561)4.42022498
21COPII vesicle coating (GO:0048208)4.41720879
22cellular extravasation (GO:0045123)4.38594539
23antigen processing and presentation of endogenous antigen (GO:0019883)4.38524131
24peptide hormone processing (GO:0016486)4.33709486
25glandular epithelial cell development (GO:0002068)4.33473251
26detection of other organism (GO:0098543)4.31168632
27glandular epithelial cell differentiation (GO:0002067)4.25956794
28neutrophil activation involved in immune response (GO:0002283)4.15701865
29cellular response to interleukin-15 (GO:0071350)4.14475617
30detection of bacterium (GO:0016045)4.14152935
31activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.06977702
32positive regulation of nuclease activity (GO:0032075)4.01031703
33negative regulation of interleukin-12 production (GO:0032695)3.90149330
34macrophage activation involved in immune response (GO:0002281)3.83555918
35positive regulation of B cell differentiation (GO:0045579)3.82514811
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.78421095
37response to peptidoglycan (GO:0032494)3.75833153
38negative T cell selection (GO:0043383)3.75109580
39regulation of nuclease activity (GO:0032069)3.75100088
40negative regulation of bone resorption (GO:0045779)3.72858876
41activated T cell proliferation (GO:0050798)3.71178948
42regulation of regulatory T cell differentiation (GO:0045589)3.68618708
43negative thymic T cell selection (GO:0045060)3.67134010
44regulation of type B pancreatic cell apoptotic process (GO:2000674)3.66156728
45regulation of B cell differentiation (GO:0045577)3.62584325
46regulation of interferon-beta biosynthetic process (GO:0045357)3.61843876
47negative regulation of T cell mediated immunity (GO:0002710)3.61006983
48detection of external biotic stimulus (GO:0098581)3.60966972
49neutrophil activation (GO:0042119)3.57651554
50endoplasmic reticulum unfolded protein response (GO:0030968)3.57355725
51B cell receptor signaling pathway (GO:0050853)3.55019026
52regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.54476952
53microglial cell activation (GO:0001774)3.53151126
54respiratory burst (GO:0045730)3.50957915
55tolerance induction (GO:0002507)3.50914136
56cellular response to unfolded protein (GO:0034620)3.50625885
57immunoglobulin mediated immune response (GO:0016064)3.48546138
58exocrine pancreas development (GO:0031017)3.47257948
59regulation of T cell tolerance induction (GO:0002664)3.43961297
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.42603974
61regulation of natural killer cell mediated immunity (GO:0002715)3.42603974
62positive regulation of gamma-delta T cell activation (GO:0046645)3.42446967
63vesicle coating (GO:0006901)3.41161806
64cytidine deamination (GO:0009972)3.40711678
65cytidine metabolic process (GO:0046087)3.40711678
66cytidine catabolic process (GO:0006216)3.40711678
67ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.39689391
68regulation of tolerance induction (GO:0002643)3.39436484
69cellular response to topologically incorrect protein (GO:0035967)3.39065401
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34831830
71response to host immune response (GO:0052572)3.34831830
72ER-nucleus signaling pathway (GO:0006984)3.34192184
73positive thymic T cell selection (GO:0045059)3.33329048
74detection of molecule of bacterial origin (GO:0032490)3.32325553
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.32059961
76pyrimidine ribonucleoside catabolic process (GO:0046133)3.31897474
77columnar/cuboidal epithelial cell development (GO:0002066)3.31841018
78detection of biotic stimulus (GO:0009595)3.31379056
79response to type I interferon (GO:0034340)3.30847076
80type I interferon signaling pathway (GO:0060337)3.29290175
81cellular response to type I interferon (GO:0071357)3.29290175
82granulocyte activation (GO:0036230)3.29009219
83ER overload response (GO:0006983)3.28684444
84negative regulation of leukocyte mediated immunity (GO:0002704)3.27223853
85positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26811872
86protein N-linked glycosylation via asparagine (GO:0018279)3.25374016
87myeloid cell activation involved in immune response (GO:0002275)3.24202082
88peptidyl-asparagine modification (GO:0018196)3.22795789
89regulation of alpha-beta T cell proliferation (GO:0046640)3.22432035
90positive regulation of tolerance induction (GO:0002645)3.21854911
91T cell migration (GO:0072678)3.21715442
92regulation of T cell mediated cytotoxicity (GO:0001914)3.21259464
93positive regulation of granulocyte differentiation (GO:0030854)3.20483136
94defense response to protozoan (GO:0042832)3.19680688
95positive regulation of insulin secretion (GO:0032024)3.18917239
96antigen processing and presentation via MHC class Ib (GO:0002475)3.16627245
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.14379342
98positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.13498101
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11614588
100macrophage activation (GO:0042116)3.10916743
101leukocyte migration involved in inflammatory response (GO:0002523)3.09203407
102regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07326716
103positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.05507274
104negative regulation of phagocytosis (GO:0050765)3.05369854
105negative regulation of glycoprotein metabolic process (GO:1903019)3.04560668
106positive T cell selection (GO:0043368)3.02788257
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02147068
108response to host (GO:0075136)3.02147068
109response to host defenses (GO:0052200)3.02147068
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01391701
111T cell selection (GO:0045058)2.99153144
112chaperone mediated protein folding requiring cofactor (GO:0051085)2.98689205
113response to protozoan (GO:0001562)2.96646172
114intra-Golgi vesicle-mediated transport (GO:0006891)2.95325869
115protein N-linked glycosylation (GO:0006487)2.94411897
116mast cell activation (GO:0045576)2.94336340
117response to endoplasmic reticulum stress (GO:0034976)2.93456743
118glycoside metabolic process (GO:0016137)2.92804131
119interferon-gamma-mediated signaling pathway (GO:0060333)2.92319914
120regulation of gamma-delta T cell differentiation (GO:0045586)2.90993233
121* leukocyte degranulation (GO:0043299)2.90535938
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88847517
123melanin metabolic process (GO:0006582)2.88193993
124interleukin-1-mediated signaling pathway (GO:0070498)2.87288407
125regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86162482
126regulation of mast cell degranulation (GO:0043304)2.85194714
127UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83859864
128dendritic cell migration (GO:0036336)2.83561268
129negative regulation of adaptive immune response (GO:0002820)2.83470409
130myeloid leukocyte mediated immunity (GO:0002444)2.83233817
131negative regulation of bone remodeling (GO:0046851)2.82627688
132regulation of cell killing (GO:0031341)2.82193619
133negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.81723406
134folic acid-containing compound biosynthetic process (GO:0009396)2.80674883
135regulation of mast cell activation (GO:0033003)2.80187540
136adaptation of signaling pathway (GO:0023058)2.79447812
137insulin secretion (GO:0030073)2.78966929
138positive regulation of histone deacetylation (GO:0031065)2.74873080
139nucleoside diphosphate catabolic process (GO:0009134)2.70767358
140melanin biosynthetic process (GO:0042438)2.70147012
141ER to Golgi vesicle-mediated transport (GO:0006888)2.69485045
142megakaryocyte development (GO:0035855)2.69215747
143leukocyte aggregation (GO:0070486)2.68158432
144regulation of insulin secretion (GO:0050796)2.68022669
145negative regulation of erythrocyte differentiation (GO:0045647)2.66183124
146regulation of gamma-delta T cell activation (GO:0046643)2.65502092
147JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64283481
148dosage compensation (GO:0007549)2.58807412
149response to unfolded protein (GO:0006986)2.56907420
150L-alpha-amino acid transmembrane transport (GO:1902475)2.55178761
151peptide catabolic process (GO:0043171)2.54453598
152positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53839488
153negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.53366889
154production of molecular mediator involved in inflammatory response (GO:0002532)2.51382140
155SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.48044363
156response to topologically incorrect protein (GO:0035966)2.46527582
157gland morphogenesis (GO:0022612)2.46278099
158negative regulation of cell killing (GO:0031342)2.46127711
159negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.46127711
160maintenance of protein localization in organelle (GO:0072595)2.42529970
161protein targeting to ER (GO:0045047)2.40957597
162regulation of peptide hormone secretion (GO:0090276)2.40380679
163Arp2/3 complex-mediated actin nucleation (GO:0034314)2.40330467
164positive regulation of peptide hormone secretion (GO:0090277)2.39546669
165cotranslational protein targeting to membrane (GO:0006613)2.38313834
166response to interleukin-15 (GO:0070672)2.36393468
167ribosomal small subunit assembly (GO:0000028)2.35948602
168thymic T cell selection (GO:0045061)2.34362180
169neutrophil mediated immunity (GO:0002446)2.34242660
170establishment of protein localization to endoplasmic reticulum (GO:0072599)2.33761985
171cellular zinc ion homeostasis (GO:0006882)2.33311407
172regulation of peptide secretion (GO:0002791)2.33171027
173positive regulation of protein deacetylation (GO:0090312)2.32484918
174cellular response to vitamin D (GO:0071305)2.31902946
175interferon-gamma production (GO:0032609)2.30834289
176protein localization to Golgi apparatus (GO:0034067)2.29148261
177protein autoprocessing (GO:0016540)2.28279596
178regulation of B cell receptor signaling pathway (GO:0050855)2.27487618
179toxin metabolic process (GO:0009404)2.25895381
180protein localization to endoplasmic reticulum (GO:0070972)2.25423356
181Golgi organization (GO:0007030)2.25202856
182negative regulation of tissue remodeling (GO:0034104)2.25180051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.23995954
2E2F7_22180533_ChIP-Seq_HELA_Human5.02492446
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.30010844
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.19866587
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94907114
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84524246
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.71143073
8GATA1_22025678_ChIP-Seq_K562_Human2.68575969
9MYC_22102868_ChIP-Seq_BL_Human2.66126688
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56568217
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41965437
12SCL_19346495_ChIP-Seq_HPC-7_Human2.40680589
13* MYB_26560356_Chip-Seq_TH2_Human2.34828858
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.33585987
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32289514
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26088894
17MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.18345267
18SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.14352284
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09622404
20VDR_21846776_ChIP-Seq_THP-1_Human2.05487560
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.05419409
22SPI1_23547873_ChIP-Seq_NB4_Human2.04435056
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02514628
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00382734
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99764274
26* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97156606
27* MYB_26560356_Chip-Seq_TH1_Human1.93999495
28* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.93182848
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88603834
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.87988439
31UTX_26944678_Chip-Seq_JUKART_Human1.87885679
32VDR_24787735_ChIP-Seq_THP-1_Human1.87663018
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86270209
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85646346
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85070000
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.82876323
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80545108
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.80033291
39GATA3_27048872_Chip-Seq_THYMUS_Human1.78771893
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78123592
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76465599
42* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74977868
43CIITA_25753668_ChIP-Seq_RAJI_Human1.73474534
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70410388
45* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.68847264
46VDR_23849224_ChIP-Seq_CD4+_Human1.65492536
47* VDR_24763502_ChIP-Seq_THP-1_Human1.65307873
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64555321
49TCF7_22412390_ChIP-Seq_EML_Mouse1.62393082
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61876000
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61438587
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59148041
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58572338
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58048852
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57896681
56FOXP3_21729870_ChIP-Seq_TREG_Human1.56236186
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53862222
58* MAF_26560356_Chip-Seq_TH2_Human1.53134060
59* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52111962
60MAF_26560356_Chip-Seq_TH1_Human1.51304342
61RUNX_20019798_ChIP-Seq_JUKART_Human1.49024178
62SPI1_23127762_ChIP-Seq_K562_Human1.46530052
63TFEB_21752829_ChIP-Seq_HELA_Human1.45344843
64GATA1_19941826_ChIP-Seq_K562_Human1.45066672
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42588924
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.42530087
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41815376
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40485185
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.40353167
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39471017
71ELK1_19687146_ChIP-ChIP_HELA_Human1.38991021
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35566860
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35008061
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33675320
75GATA3_26560356_Chip-Seq_TH2_Human1.30932091
76GATA2_19941826_ChIP-Seq_K562_Human1.30106393
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29902772
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.27763018
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26270144
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.25932294
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25793281
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25539337
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24649076
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24588951
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.24176216
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.23460653
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20659676
88* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18307904
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.18159376
90ETS1_22383799_ChIP-Seq_G1ME_Mouse1.16713994
91KDM5A_27292631_Chip-Seq_BREAST_Human1.13812819
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12909599
93PU_27001747_Chip-Seq_BMDM_Mouse1.12693563
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12490781
95GABP_19822575_ChIP-Seq_HepG2_Human1.12467699
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09586191
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05500472
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04954946
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04516714
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03032376
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02831529
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02102339
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01408568
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01390999
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00231926
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99219783
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98923370
108SMRT_27268052_Chip-Seq_Bcells_Human0.98484711
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.98114812
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97346536
111MYC_18555785_ChIP-Seq_MESCs_Mouse0.96784151
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96645224
113EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95522631
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94105943
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93961587
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92349286
117NCOR1_26117541_ChIP-Seq_K562_Human0.92329222
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92121240
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92076951
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.91889118
121CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90211093
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90085214
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89731117
124HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89171238
125GATA3_26560356_Chip-Seq_TH1_Human0.86430107
126BCL6_27268052_Chip-Seq_Bcells_Human0.86386680
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86304153
128STAT1_20625510_ChIP-Seq_HELA_Human0.84480152
129TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84438880
130PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80366863
131GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79912200
132BCOR_27268052_Chip-Seq_Bcells_Human0.79073193
133* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78132384
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78003383
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.76507531
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75713258
137P300_27268052_Chip-Seq_Bcells_Human0.75465777
138PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74350810
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74195763
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73848717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.82998219
2MP0002693_abnormal_pancreas_physiology3.57984133
3* MP0002877_abnormal_melanocyte_morpholog3.12469280
4MP0001944_abnormal_pancreas_morphology2.94556461
5MP0003763_abnormal_thymus_physiology2.50855469
6MP0000372_irregular_coat_pigmentation2.49542756
7MP0006082_CNS_inflammation2.49100402
8MP0003300_gastrointestinal_ulcer2.47313634
9MP0002909_abnormal_adrenal_gland2.44997711
10MP0000678_abnormal_parathyroid_gland2.36471384
11MP0005220_abnormal_exocrine_pancreas2.34469048
12MP0001986_abnormal_taste_sensitivity2.25565177
13MP0004264_abnormal_extraembryonic_tissu2.18510165
14MP0005379_endocrine/exocrine_gland_phen2.16949899
15MP0004043_abnormal_pH_regulation2.16148467
16MP0009780_abnormal_chondrocyte_physiolo2.08725448
17MP0003693_abnormal_embryo_hatching2.05353069
18MP0003866_abnormal_defecation1.95772562
19MP0005671_abnormal_response_to1.94675869
20MP0000569_abnormal_digit_pigmentation1.83705735
21MP0005310_abnormal_salivary_gland1.79943451
22MP0003172_abnormal_lysosome_physiology1.77681832
23MP0001835_abnormal_antigen_presentation1.77589298
24MP0006054_spinal_hemorrhage1.75429361
25MP0010386_abnormal_urinary_bladder1.75018155
26MP0002166_altered_tumor_susceptibility1.73849049
27MP0003436_decreased_susceptibility_to1.70074052
28MP0003724_increased_susceptibility_to1.62756141
29MP0002396_abnormal_hematopoietic_system1.62170296
30MP0002928_abnormal_bile_duct1.60709937
31MP0000013_abnormal_adipose_tissue1.58655568
32MP0004808_abnormal_hematopoietic_stem1.55885393
33MP0003283_abnormal_digestive_organ1.54336141
34MP0005387_immune_system_phenotype1.52677466
35MP0001790_abnormal_immune_system1.52677466
36MP0005000_abnormal_immune_tolerance1.51675594
37MP0005174_abnormal_tail_pigmentation1.51343988
38MP0000685_abnormal_immune_system1.50835162
39MP0004782_abnormal_surfactant_physiolog1.49764491
40* MP0002420_abnormal_adaptive_immunity1.49398101
41MP0005058_abnormal_lysosome_morphology1.46921102
42* MP0001819_abnormal_immune_cell1.46748973
43MP0002078_abnormal_glucose_homeostasis1.46497841
44* MP0002398_abnormal_bone_marrow1.45225971
45MP0002132_abnormal_respiratory_system1.44510610
46MP0002638_abnormal_pupillary_reflex1.44304516
47MP0008469_abnormal_protein_level1.42864122
48MP0005075_abnormal_melanosome_morpholog1.41067815
49MP0005025_abnormal_response_to1.40595548
50MP0000015_abnormal_ear_pigmentation1.40265616
51MP0000465_gastrointestinal_hemorrhage1.40233433
52MP0002405_respiratory_system_inflammati1.38765294
53MP0000703_abnormal_thymus_morphology1.37724382
54MP0002723_abnormal_immune_serum1.35984906
55MP0001800_abnormal_humoral_immune1.34563018
56MP0009785_altered_susceptibility_to1.32555333
57MP0002138_abnormal_hepatobiliary_system1.32512894
58MP0000716_abnormal_immune_system1.31449125
59MP0001873_stomach_inflammation1.30583259
60MP0010155_abnormal_intestine_physiology1.30502099
61MP0009764_decreased_sensitivity_to1.28607280
62* MP0002419_abnormal_innate_immunity1.26625756
63MP0001845_abnormal_inflammatory_respons1.24881224
64MP0009333_abnormal_splenocyte_physiolog1.24711122
65MP0001765_abnormal_ion_homeostasis1.24618009
66MP0002452_abnormal_antigen_presenting1.23877949
67MP0000490_abnormal_crypts_of1.19871065
68* MP0005464_abnormal_platelet_physiology1.19472134
69* MP0005408_hypopigmentation1.18450928
70MP0003252_abnormal_bile_duct1.18112190
71MP0005451_abnormal_body_composition1.18061901
72MP0002009_preneoplasia1.17562923
73MP0004947_skin_inflammation1.16579763
74MP0002148_abnormal_hypersensitivity_rea1.15680256
75MP0002006_tumorigenesis1.14976678
76* MP0000371_diluted_coat_color1.14555392
77MP0002722_abnormal_immune_system1.13736533
78MP0003303_peritoneal_inflammation1.11393013
79MP0003045_fibrosis1.10725965
80MP0003806_abnormal_nucleotide_metabolis1.10575953
81* MP0002429_abnormal_blood_cell1.10236465
82MP0002277_abnormal_respiratory_mucosa1.10087933
83MP0008260_abnormal_autophagy1.09156927
84MP0004883_abnormal_blood_vessel1.07002824
85MP0000613_abnormal_salivary_gland1.05874559
86MP0008961_abnormal_basal_metabolism1.05105509
87MP0010094_abnormal_chromosome_stability1.04433022
88MP0006072_abnormal_retinal_apoptosis1.02899367
89MP0003828_pulmonary_edema1.00416987
90MP0001853_heart_inflammation1.00019449
91MP0001663_abnormal_digestive_system0.99266702
92MP0000689_abnormal_spleen_morphology0.98873077
93MP0003656_abnormal_erythrocyte_physiolo0.96967212
94MP0010352_gastrointestinal_tract_polyps0.96866468
95* MP0002095_abnormal_skin_pigmentation0.96512942
96MP0005164_abnormal_response_to0.96076869
97MP0009643_abnormal_urine_homeostasis0.94322147
98MP0010307_abnormal_tumor_latency0.93538131
99MP0003868_abnormal_feces_composition0.92995353
100MP0005084_abnormal_gallbladder_morpholo0.92859112
101MP0008007_abnormal_cellular_replicative0.92752450
102MP0002998_abnormal_bone_remodeling0.92578895
103MP0009763_increased_sensitivity_to0.91565565
104MP0001851_eye_inflammation0.90302277
105MP0001270_distended_abdomen0.90230376
106MP0000858_altered_metastatic_potential0.89666477
107* MP0003953_abnormal_hormone_level0.88824462
108MP0000681_abnormal_thyroid_gland0.88689597
109MP0003943_abnormal_hepatobiliary_system0.88327291
110MP0001545_abnormal_hematopoietic_system0.87527053
111MP0005397_hematopoietic_system_phenotyp0.87527053
112MP0004381_abnormal_hair_follicle0.86528639
113MP0008004_abnormal_stomach_pH0.86430698
114* MP0001186_pigmentation_phenotype0.85372536
115MP0000003_abnormal_adipose_tissue0.84927919
116MP0003191_abnormal_cellular_cholesterol0.84675229
117MP0001533_abnormal_skeleton_physiology0.84294336
118MP0002019_abnormal_tumor_incidence0.83968162
119MP0005166_decreased_susceptibility_to0.83600706
120MP0009278_abnormal_bone_marrow0.80264551
121MP0010234_abnormal_vibrissa_follicle0.79910368
122MP0005257_abnormal_intraocular_pressure0.78254052
123MP0003448_altered_tumor_morphology0.77895946
124MP0003195_calcinosis0.77166547
125MP0005076_abnormal_cell_differentiation0.77066169
126MP0005171_absent_coat_pigmentation0.73279480
127MP0005083_abnormal_biliary_tract0.70065732
128MP0000609_abnormal_liver_physiology0.67812133
129MP0009765_abnormal_xenobiotic_induced0.66667549
130MP0003075_altered_response_to0.66331640
131MP0005085_abnormal_gallbladder_physiolo0.63801850
132MP0005381_digestive/alimentary_phenotyp0.63711730
133MP0002933_joint_inflammation0.63005597
134MP0002136_abnormal_kidney_physiology0.62871119
135MP0005360_urolithiasis0.61496904
136MP0003646_muscle_fatigue0.60811273
137MP0005319_abnormal_enzyme/_coenzyme0.58903634
138MP0005390_skeleton_phenotype0.57617524

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.98334656
2Stomatitis (HP:0010280)4.91250359
3Hypoglycemic seizures (HP:0002173)4.77766315
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.71917038
5Retrobulbar optic neuritis (HP:0100654)4.63352375
6Optic neuritis (HP:0100653)4.63352375
7Abnormality of macrophages (HP:0004311)4.57583343
8Symptomatic seizures (HP:0011145)4.42123441
9Hypoglycemic coma (HP:0001325)3.98366299
10Gastrointestinal infarctions (HP:0005244)3.93024735
11* Abnormal delayed hypersensitivity skin test (HP:0002963)3.92154996
12Recurrent gram-negative bacterial infections (HP:0005420)3.78451653
13Encephalitis (HP:0002383)3.74239618
14Chronic mucocutaneous candidiasis (HP:0002728)3.71563081
15Recurrent cutaneous fungal infections (HP:0011370)3.71563081
16Mucopolysacchariduria (HP:0008155)3.70062479
17Urinary glycosaminoglycan excretion (HP:0003541)3.70062479
18Dysostosis multiplex (HP:0000943)3.68529814
19Chronic obstructive pulmonary disease (HP:0006510)3.64957938
20Obstructive lung disease (HP:0006536)3.64957938
21Recurrent skin infections (HP:0001581)3.59150459
22Mediastinal lymphadenopathy (HP:0100721)3.59146048
23Vasculitis (HP:0002633)3.55506039
24Decreased circulating renin level (HP:0003351)3.53020242
25Insulin-resistant diabetes mellitus (HP:0000831)3.52820737
26* Meningitis (HP:0001287)3.52611055
27Keratoconjunctivitis sicca (HP:0001097)3.47651081
28Abnormality of the pancreatic islet cells (HP:0006476)3.43431754
29Abnormality of endocrine pancreas physiology (HP:0012093)3.43431754
30Hypoplasia of the fovea (HP:0007750)3.40359117
31Aplasia/Hypoplasia of the fovea (HP:0008060)3.40359117
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.40039950
33Abnormality of polysaccharide metabolism (HP:0011012)3.40039950
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.40039950
35Hemoptysis (HP:0002105)3.33883436
36Keratoconjunctivitis (HP:0001096)3.31548561
37Pancreatic islet-cell hyperplasia (HP:0004510)3.21962539
38* Pulmonary infiltrates (HP:0002113)3.20213048
39IgM deficiency (HP:0002850)3.19442047
40Hyperglycemia (HP:0003074)3.16449492
41Abnormality of calcium-phosphate metabolism (HP:0100530)3.14463223
42Interstitial pulmonary disease (HP:0006530)3.11420191
43Large for gestational age (HP:0001520)3.09520370
44Granulocytopenia (HP:0001913)3.07999138
45Abnormality of the fovea (HP:0000493)3.06967402
46Leukocytosis (HP:0001974)3.02627379
47Eczematoid dermatitis (HP:0000976)3.01245893
48Papilledema (HP:0001085)2.97421641
49Pustule (HP:0200039)2.96864553
50Gingivitis (HP:0000230)2.94813452
51Urticaria (HP:0001025)2.87529611
52Prolonged bleeding time (HP:0003010)2.83811367
53T lymphocytopenia (HP:0005403)2.81751266
54Thrombocytosis (HP:0001894)2.80796449
55Late onset (HP:0003584)2.80063888
56Eosinophilia (HP:0001880)2.78910978
57Alveolar cell carcinoma (HP:0006519)2.76627781
58Aplasia/Hypoplasia of the macula (HP:0008059)2.75985858
59Arterial thrombosis (HP:0004420)2.75273428
60Increased IgM level (HP:0003496)2.70058627
61Neoplasm of the tracheobronchial system (HP:0100552)2.69192128
62Anorexia (HP:0002039)2.65894602
63Hypochromic anemia (HP:0001931)2.65133887
64Pulmonary embolism (HP:0002204)2.64736489
65Gingival bleeding (HP:0000225)2.63295287
66Abnormality of eosinophils (HP:0001879)2.63263050
67* Ocular albinism (HP:0001107)2.62689839
68Abnormal protein glycosylation (HP:0012346)2.60185969
69Abnormal glycosylation (HP:0012345)2.60185969
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60185969
71Abnormal protein N-linked glycosylation (HP:0012347)2.60185969
72Episodic fever (HP:0001954)2.59941244
73Panhypogammaglobulinemia (HP:0003139)2.59808517
74Abnormality of T cell number (HP:0011839)2.59198241
75Recurrent abscess formation (HP:0002722)2.55769479
76Hypochromic microcytic anemia (HP:0004840)2.55126563
77Abnormality of the pleura (HP:0002103)2.54150072
78Generalized aminoaciduria (HP:0002909)2.54070444
79Prominent metopic ridge (HP:0005487)2.52882758
80Epistaxis (HP:0000421)2.52073087
81Limb hypertonia (HP:0002509)2.51213537
8211 pairs of ribs (HP:0000878)2.50644005
83Gangrene (HP:0100758)2.46229745
84Chronic bronchitis (HP:0004469)2.46218278
85Chronic otitis media (HP:0000389)2.45802691
86Aplasia/Hypoplasia affecting the retina (HP:0008061)2.44245184
87Myositis (HP:0100614)2.44212551
88Joint swelling (HP:0001386)2.43046117
89Type I transferrin isoform profile (HP:0003642)2.42847508
90IgG deficiency (HP:0004315)2.41979589
91Ketoacidosis (HP:0001993)2.41013772
92Vacuolated lymphocytes (HP:0001922)2.38538284
93Abnormal pancreas size (HP:0012094)2.37651205
94Autoimmune thrombocytopenia (HP:0001973)2.36945009
95Hypothermia (HP:0002045)2.36561421
96Recurrent fungal infections (HP:0002841)2.36374509
97Nasal polyposis (HP:0100582)2.35944143
98Thoracolumbar scoliosis (HP:0002944)2.35837681
99Petechiae (HP:0000967)2.35506319
100Hypergammaglobulinemia (HP:0010702)2.34997176
101Recurrent viral infections (HP:0004429)2.33185439
102* Abnormality of T cells (HP:0002843)2.31357351
103Hyperactive renin-angiotensin system (HP:0000841)2.31241601
104Volvulus (HP:0002580)2.30959648
105Bronchitis (HP:0012387)2.28986330
106* Abnormality of T cell physiology (HP:0011840)2.28220961
107Microcytic anemia (HP:0001935)2.27745804
108Skin rash (HP:0000988)2.26671351
109Insulin resistance (HP:0000855)2.22914421
110Recurrent bacterial skin infections (HP:0005406)2.22652172
111Abnormality of iron homeostasis (HP:0011031)2.21239995
112Abnormality of the fingertips (HP:0001211)2.20445585
113Abnormality of renin-angiotensin system (HP:0000847)2.19790364
114Increased serum ferritin (HP:0003281)2.19496622
115Periodontitis (HP:0000704)2.19325479
116Severe combined immunodeficiency (HP:0004430)2.18528483
117Recurrent bronchitis (HP:0002837)2.17498365
118Aplastic anemia (HP:0001915)2.12904196
119Spontaneous hematomas (HP:0007420)2.11784870
120Osteomyelitis (HP:0002754)2.11447305
121Hypokalemia (HP:0002900)2.09736864
122Abnormality of the nasal mucosa (HP:0000433)2.09224808
123Hypoplasia of the thymus (HP:0000778)2.08679026
124Abnormality of the intrinsic pathway (HP:0010989)2.05740589
125Abnormality of transition element cation homeostasis (HP:0011030)2.03765364
126Acne (HP:0001061)2.03618969
127* Iris hypopigmentation (HP:0007730)2.02712194
128Abnormality of glycolipid metabolism (HP:0010969)2.02134810
129Abnormality of liposaccharide metabolism (HP:0010968)2.02134810
130Abnormality of glycosphingolipid metabolism (HP:0004343)2.02134810
131Abnormality of the prostate (HP:0008775)2.01850605
132Autoimmune hemolytic anemia (HP:0001890)2.01282040
133Osteomalacia (HP:0002749)1.98030268
134B lymphocytopenia (HP:0010976)1.97558703
135Abnormality of B cell number (HP:0010975)1.97558703
136Abnormality of the metopic suture (HP:0005556)1.97508786
137Hyperparathyroidism (HP:0000843)1.96792535
138Abnormality of the pericardium (HP:0001697)1.96389005
139Severe short stature (HP:0003510)1.95386426
140Hematochezia (HP:0002573)1.94240090
141Hyperkalemia (HP:0002153)1.93794883
142Albinism (HP:0001022)1.93645706
143Cellulitis (HP:0100658)1.93314300
144Elevated erythrocyte sedimentation rate (HP:0003565)1.92211489
145Peritonitis (HP:0002586)1.92088398
146Inflammation of the large intestine (HP:0002037)1.91871241
147Amyloidosis (HP:0011034)1.91813864
148Gastrointestinal inflammation (HP:0004386)1.91750450
149Cheilitis (HP:0100825)1.90787224
150Gastrointestinal stroma tumor (HP:0100723)1.90718183
151Fatigue (HP:0012378)1.90479040
152Chest pain (HP:0100749)1.90167497
153Acute hepatic failure (HP:0006554)1.88630342
154Colitis (HP:0002583)1.88608710
155Chronic diarrhea (HP:0002028)1.87900362
156Abnormality of small intestinal villus morphology (HP:0011472)1.83166802
157Villous atrophy (HP:0011473)1.83166802
158Lymphopenia (HP:0001888)1.82567929
159Conjugated hyperbilirubinemia (HP:0002908)1.79854940
160IgA deficiency (HP:0002720)1.77347631
161Orchitis (HP:0100796)1.76507209
162Abnormality of cells of the lymphoid lineage (HP:0012140)1.73175515
163Dysautonomia (HP:0002459)1.71625917
164Increased IgE level (HP:0003212)1.70843644
165Abnormality of chloride homeostasis (HP:0011422)1.70179845
166Abnormality of potassium homeostasis (HP:0011042)1.70046388
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69225623
168Bronchiectasis (HP:0002110)1.67350404
169Unilateral renal agenesis (HP:0000122)1.67016973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.92884166
2TAOK34.48186275
3INSRR4.26323311
4PASK4.18052316
5FLT33.00108580
6MAPK152.97340541
7HIPK22.84979897
8IRAK42.63941779
9ERN12.49174941
10MAP4K12.44125825
11ZAP702.18909429
12IRAK32.06492953
13BRD42.05701572
14FRK1.99281813
15TEC1.94344777
16TXK1.93398101
17EEF2K1.84950171
18SCYL21.81406245
19BTK1.75451076
20ITK1.68396645
21JAK31.60794274
22TNK21.57042768
23BMPR21.54291001
24EIF2AK31.53361704
25MST1R1.48410287
26EPHA31.47506278
27BRSK21.46058923
28PRPF4B1.44645312
29MAP3K21.43793794
30TRIB31.33873873
31CAMKK21.31168072
32FGFR31.26738409
33PTK61.22592591
34NLK1.21101201
35MAP3K11.12632937
36IKBKE1.11339497
37MATK1.08721538
38PKN21.08325627
39KSR21.04017554
40IRAK11.01191287
41EPHB10.98577747
42TAOK10.96826305
43YES10.96021167
44PIK3CG0.93379355
45SYK0.90658372
46PRKCQ0.87949239
47CSF1R0.86737905
48TYK20.86653106
49FGFR40.86485708
50TESK10.85029601
51JAK10.84592146
52KIT0.84249978
53FGR0.82257032
54PDK10.81645988
55MAP3K140.81505192
56CSK0.79183705
57MAP3K110.78650788
58ADRBK20.78504296
59STK100.76545138
60PRKD30.76165061
61SRPK10.75351811
62STK160.74179834
63LCK0.72561221
64JAK20.71301646
65MAP2K30.69207020
66RPS6KB20.69092046
67PRKCH0.67879417
68SIK30.66482200
69RPS6KB10.66351135
70MARK30.65790762
71RPS6KA20.65296153
72RPS6KA40.64212318
73MAPKAPK30.62955899
74PTK2B0.62509597
75CHUK0.62444770
76MAP3K30.62240241
77MAP3K50.60401410
78MAP3K60.59871881
79PIM10.58356945
80VRK10.57233943
81PDPK10.57151977
82MAPK110.55570625
83TRPM70.54901353
84STK240.54541612
85ATR0.53458580
86LRRK20.52836909
87MAP3K70.52456752
88WNK10.52251080
89DAPK20.50711847
90CDK80.50186192
91GRK70.49727841
92FYN0.49680564
93FES0.49091897
94HCK0.47000428
95TSSK60.46995025
96LYN0.46812874
97GRK60.44577143
98RPS6KL10.44277677
99RPS6KC10.44277677
100RPS6KA60.44007052
101CDK90.43794525
102MAPK120.42983265
103TAOK20.42762344
104ALK0.42712145
105PRKD20.42355102
106GRK10.41842791
107TBK10.41296720
108UHMK10.39807991
109ACVR1B0.39230939
110PRKG20.38787535
111RAF10.38686643
112RET0.38278683
113CLK10.37752118
114MAP3K130.37389847
115IKBKB0.37135494
116PTK20.36206695
117IRAK20.35652006
118TGFBR20.35627597
119TESK20.34840019
120PRKAA20.34547367
121DYRK1B0.34437172
122CDC70.34348920
123MET0.33496793
124BRSK10.33228299
125TGFBR10.32730047
126BLK0.32437642
127MAP2K60.32195874
128STK110.31537334
129IGF1R0.31514364
130NEK90.30907755
131SGK30.30827410
132MAPKAPK20.30592092
133MAPK70.30248347
134MAPK30.30021647
135CDK70.29614572
136SGK20.29344355
137ADRBK10.28981872
138KSR10.26716663
139ABL10.25433960
140PRKCD0.25233630
141MARK20.23890532

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.75573888
2Protein export_Homo sapiens_hsa030604.67565252
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.98459399
4Allograft rejection_Homo sapiens_hsa053302.88660478
5Autoimmune thyroid disease_Homo sapiens_hsa053202.77140464
6Staphylococcus aureus infection_Homo sapiens_hsa051502.59518502
7Other glycan degradation_Homo sapiens_hsa005112.27500444
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.08826175
9N-Glycan biosynthesis_Homo sapiens_hsa005102.04162928
10Antigen processing and presentation_Homo sapiens_hsa046122.00183924
11Asthma_Homo sapiens_hsa053101.95697149
12Type I diabetes mellitus_Homo sapiens_hsa049401.87044933
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83453967
14Carbohydrate digestion and absorption_Homo sapiens_hsa049731.82737033
15Insulin secretion_Homo sapiens_hsa049111.70123220
16Primary immunodeficiency_Homo sapiens_hsa053401.62491349
17Sulfur metabolism_Homo sapiens_hsa009201.60738712
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56402916
19Malaria_Homo sapiens_hsa051441.55927142
20Type II diabetes mellitus_Homo sapiens_hsa049301.55518522
21Lysosome_Homo sapiens_hsa041421.48084227
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29102837
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25544446
24Rheumatoid arthritis_Homo sapiens_hsa053231.22575241
25Measles_Homo sapiens_hsa051621.19095062
26Viral myocarditis_Homo sapiens_hsa054161.16398328
27Prolactin signaling pathway_Homo sapiens_hsa049171.14109361
28Non-homologous end-joining_Homo sapiens_hsa034501.12376183
29Selenocompound metabolism_Homo sapiens_hsa004501.09862271
30African trypanosomiasis_Homo sapiens_hsa051431.09570679
31Hematopoietic cell lineage_Homo sapiens_hsa046401.08963095
32Leishmaniasis_Homo sapiens_hsa051401.08522023
33Legionellosis_Homo sapiens_hsa051341.05087743
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05043566
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03958403
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.03364675
37Galactose metabolism_Homo sapiens_hsa000521.00674317
38DNA replication_Homo sapiens_hsa030300.99745386
39Phagosome_Homo sapiens_hsa041450.99548781
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94240214
41Vibrio cholerae infection_Homo sapiens_hsa051100.93890383
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93756587
43Acute myeloid leukemia_Homo sapiens_hsa052210.93431882
44T cell receptor signaling pathway_Homo sapiens_hsa046600.90651439
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89281581
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.89030549
47Insulin resistance_Homo sapiens_hsa049310.88425926
48Pancreatic secretion_Homo sapiens_hsa049720.87056808
49Osteoclast differentiation_Homo sapiens_hsa043800.87047457
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.83202358
51Herpes simplex infection_Homo sapiens_hsa051680.83105698
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82682355
53Hepatitis B_Homo sapiens_hsa051610.82166529
54Homologous recombination_Homo sapiens_hsa034400.80891593
55Folate biosynthesis_Homo sapiens_hsa007900.80307725
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79525079
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79396531
58Circadian rhythm_Homo sapiens_hsa047100.78824245
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78521695
60Mismatch repair_Homo sapiens_hsa034300.76759454
61Thyroid cancer_Homo sapiens_hsa052160.76379336
62Linoleic acid metabolism_Homo sapiens_hsa005910.75378288
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74575426
64RNA degradation_Homo sapiens_hsa030180.73916407
65Chronic myeloid leukemia_Homo sapiens_hsa052200.73696180
66ABC transporters_Homo sapiens_hsa020100.72847840
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72747346
68Dorso-ventral axis formation_Homo sapiens_hsa043200.70608128
69Glucagon signaling pathway_Homo sapiens_hsa049220.69523870
70Shigellosis_Homo sapiens_hsa051310.68857042
71Salmonella infection_Homo sapiens_hsa051320.68599882
72Base excision repair_Homo sapiens_hsa034100.68202831
73VEGF signaling pathway_Homo sapiens_hsa043700.67779475
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67236169
75Toxoplasmosis_Homo sapiens_hsa051450.66333634
76Viral carcinogenesis_Homo sapiens_hsa052030.65375099
77Chemokine signaling pathway_Homo sapiens_hsa040620.64723898
78Cell cycle_Homo sapiens_hsa041100.64417636
79Influenza A_Homo sapiens_hsa051640.63598145
80Thyroid hormone synthesis_Homo sapiens_hsa049180.63092964
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61813510
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59756797
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.59602247
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59063471
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58208759
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.58145358
87B cell receptor signaling pathway_Homo sapiens_hsa046620.57708803
88Sphingolipid metabolism_Homo sapiens_hsa006000.56026534
89Arachidonic acid metabolism_Homo sapiens_hsa005900.55120663
90Prostate cancer_Homo sapiens_hsa052150.54889423
91Pancreatic cancer_Homo sapiens_hsa052120.54863704
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54455052
93p53 signaling pathway_Homo sapiens_hsa041150.54414657
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.53191062
95Apoptosis_Homo sapiens_hsa042100.52718400
96Pertussis_Homo sapiens_hsa051330.52340080
97Fanconi anemia pathway_Homo sapiens_hsa034600.51738311
98mTOR signaling pathway_Homo sapiens_hsa041500.51011113
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50982353
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50926736
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50384806
102Inositol phosphate metabolism_Homo sapiens_hsa005620.50222906
103Cocaine addiction_Homo sapiens_hsa050300.49765102
104Graft-versus-host disease_Homo sapiens_hsa053320.49190881
105Caffeine metabolism_Homo sapiens_hsa002320.49102901
106Platelet activation_Homo sapiens_hsa046110.49083113
107Renin-angiotensin system_Homo sapiens_hsa046140.48563401
108Renal cell carcinoma_Homo sapiens_hsa052110.47287862
109TNF signaling pathway_Homo sapiens_hsa046680.46750960
110HTLV-I infection_Homo sapiens_hsa051660.44320042
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43651691
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.43300559
113Spliceosome_Homo sapiens_hsa030400.43258299
114Tuberculosis_Homo sapiens_hsa051520.43237915
115Epstein-Barr virus infection_Homo sapiens_hsa051690.42584170
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.42552516
117FoxO signaling pathway_Homo sapiens_hsa040680.42139006
118Regulation of autophagy_Homo sapiens_hsa041400.42128625
119Starch and sucrose metabolism_Homo sapiens_hsa005000.41776255
120Ether lipid metabolism_Homo sapiens_hsa005650.39283586
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38915257
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38706743
123Hepatitis C_Homo sapiens_hsa051600.37691948
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35701765
125Estrogen signaling pathway_Homo sapiens_hsa049150.35394353
126Insulin signaling pathway_Homo sapiens_hsa049100.35239708
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35010692
128Endocytosis_Homo sapiens_hsa041440.34885259
129Non-small cell lung cancer_Homo sapiens_hsa052230.34268643
130HIF-1 signaling pathway_Homo sapiens_hsa040660.34020240
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33021238
132Nitrogen metabolism_Homo sapiens_hsa009100.31568209
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.31440489
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29766035
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27916846
136Choline metabolism in cancer_Homo sapiens_hsa052310.26252773
137Complement and coagulation cascades_Homo sapiens_hsa046100.26169937
138MAPK signaling pathway_Homo sapiens_hsa040100.23407457
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22583605

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »