RAB27B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.98416628
2regulation of platelet aggregation (GO:0090330)5.48422561
3neutrophil activation involved in immune response (GO:0002283)5.43367316
4vocalization behavior (GO:0071625)5.00984100
5platelet aggregation (GO:0070527)4.95098252
6regulation of platelet activation (GO:0010543)4.76770776
7protein neddylation (GO:0045116)4.68751775
8neuron cell-cell adhesion (GO:0007158)4.63028622
9regulation of integrin-mediated signaling pathway (GO:2001044)4.59604188
10negative regulation of homotypic cell-cell adhesion (GO:0034111)4.52612246
11synaptic vesicle exocytosis (GO:0016079)4.48673860
12adenosine receptor signaling pathway (GO:0001973)4.48380258
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47029215
14regulation of integrin activation (GO:0033623)4.45298240
15negative regulation of dendrite morphogenesis (GO:0050774)4.42453954
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.27090392
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.25185423
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20844698
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.20789383
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.19979243
21megakaryocyte development (GO:0035855)4.19933623
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.15058021
23angiogenesis involved in wound healing (GO:0060055)4.12054549
24regulation of glutamate receptor signaling pathway (GO:1900449)4.03688199
25platelet degranulation (GO:0002576)3.99042775
26protein localization to synapse (GO:0035418)3.97396570
27positive regulation of mast cell activation (GO:0033005)3.93420155
28leukocyte migration involved in inflammatory response (GO:0002523)3.92941841
29neuronal action potential propagation (GO:0019227)3.91156061
30glutamate receptor signaling pathway (GO:0007215)3.90473717
31response to histamine (GO:0034776)3.90118630
32neuron-neuron synaptic transmission (GO:0007270)3.88184143
33negative regulation of norepinephrine secretion (GO:0010700)3.88025409
34lipoxygenase pathway (GO:0019372)3.87445340
35blood coagulation, intrinsic pathway (GO:0007597)3.87404417
36regulation of synaptic vesicle exocytosis (GO:2000300)3.87221104
37regulation of Golgi to plasma membrane protein transport (GO:0042996)3.87134593
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.83892009
39synaptic transmission, glutamatergic (GO:0035249)3.83699224
40positive regulation of receptor recycling (GO:0001921)3.80235979
41mesodermal cell differentiation (GO:0048333)3.79789713
42glutamate secretion (GO:0014047)3.73568694
43positive regulation of Rho protein signal transduction (GO:0035025)3.73035025
44establishment of skin barrier (GO:0061436)3.71374893
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70351320
46presynaptic membrane assembly (GO:0097105)3.67966683
47negative regulation of platelet activation (GO:0010544)3.66284278
48regulation of lipoprotein metabolic process (GO:0050746)3.65296280
49negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.60827827
50neurotransmitter secretion (GO:0007269)3.59874492
51platelet activation (GO:0030168)3.58898935
52proline transport (GO:0015824)3.57557487
53positive regulation of macrophage differentiation (GO:0045651)3.56233571
54neuronal action potential (GO:0019228)3.54250949
55homotypic cell-cell adhesion (GO:0034109)3.53763685
56hypotonic response (GO:0006971)3.53438504
57negative regulation of protein localization to plasma membrane (GO:1903077)3.52301242
58positive regulation of blood coagulation (GO:0030194)3.51281118
59positive regulation of hemostasis (GO:1900048)3.51281118
60negative regulation of protein localization to cell surface (GO:2000009)3.50802925
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.49601579
62regulation of homotypic cell-cell adhesion (GO:0034110)3.46868265
63postsynaptic membrane organization (GO:0001941)3.44678705
64neutrophil activation (GO:0042119)3.44600465
65regulation of synaptic vesicle transport (GO:1902803)3.44536415
66regulation of clathrin-mediated endocytosis (GO:2000369)3.42367450
67negative regulation of dendrite development (GO:2000171)3.39476521
68positive regulation of endothelial cell differentiation (GO:0045603)3.39046773
69transferrin transport (GO:0033572)3.39004536
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.35294064
71startle response (GO:0001964)3.34712007
72hepatocyte apoptotic process (GO:0097284)3.32567516
73regulation of water loss via skin (GO:0033561)3.28021862
74protein localization to cilium (GO:0061512)3.27021109
75serotonin receptor signaling pathway (GO:0007210)3.25285091
76regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.23892036
77positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.23516750
78gamma-aminobutyric acid transport (GO:0015812)3.23358569
79long-term synaptic potentiation (GO:0060291)3.21982151
80positive regulation of coagulation (GO:0050820)3.21287351
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19988604
82presynaptic membrane organization (GO:0097090)3.18767687
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18388073
84ATP hydrolysis coupled proton transport (GO:0015991)3.18310242
85energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.18310242
86negative regulation of T-helper cell differentiation (GO:0045623)3.17745159
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17745159
88negative regulation of stress fiber assembly (GO:0051497)3.17134602
89definitive hemopoiesis (GO:0060216)3.16552108
90platelet formation (GO:0030220)3.16080990
91regulation of vesicle fusion (GO:0031338)3.15778940
92G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.15495997
93ferric iron transport (GO:0015682)3.13698724
94trivalent inorganic cation transport (GO:0072512)3.13698724
95regulation of synaptic transmission, GABAergic (GO:0032228)3.13628498
96purinergic nucleotide receptor signaling pathway (GO:0035590)3.13216831
97regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12956842
98neuron recognition (GO:0008038)3.12831903
99neurotransmitter transport (GO:0006836)3.10775686
100regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10521293
101negative regulation of interleukin-17 production (GO:0032700)3.10378912
102regulation of synaptic transmission, glutamatergic (GO:0051966)3.09565247
103cyclooxygenase pathway (GO:0019371)3.08204258
104detection of calcium ion (GO:0005513)3.07520124
105striatum development (GO:0021756)3.03381778
106neurotransmitter-gated ion channel clustering (GO:0072578)3.03178167
107transmission of nerve impulse (GO:0019226)3.01154550
108long-chain fatty acid biosynthetic process (GO:0042759)3.00970050
109cellular response to prostaglandin stimulus (GO:0071379)3.00810749
110granulocyte activation (GO:0036230)2.99889841
111synaptic vesicle maturation (GO:0016188)2.99458439
112regulation of postsynaptic membrane potential (GO:0060078)2.99049976
113relaxation of smooth muscle (GO:0044557)2.97918254
114regulation of blood coagulation (GO:0030193)2.96013806
115regulation of hemostasis (GO:1900046)2.96013806
116negative regulation of heart contraction (GO:0045822)2.95052008
117membrane depolarization during action potential (GO:0086010)2.94997643
118negative regulation of adherens junction organization (GO:1903392)2.93102692
119negative regulation of focal adhesion assembly (GO:0051895)2.93102692
120negative regulation of cell junction assembly (GO:1901889)2.93102692
121urinary tract smooth muscle contraction (GO:0014848)2.93027533
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92102221
123regulation of neuronal synaptic plasticity (GO:0048168)2.89789100
124synaptic transmission (GO:0007268)2.87764047
125regulation of protein kinase A signaling (GO:0010738)2.87588950
126desmosome organization (GO:0002934)2.86949333
127extracellular fibril organization (GO:0043206)2.85936812
128vesicle targeting (GO:0006903)2.85494067
129regulation of receptor recycling (GO:0001919)2.85313589
130synaptic vesicle docking involved in exocytosis (GO:0016081)2.84692182
131positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.84635798
132positive regulation of synapse assembly (GO:0051965)2.84520872
133membrane depolarization (GO:0051899)2.84454157
134triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.83388092
135behavioral response to pain (GO:0048266)2.82496435
136synapse assembly (GO:0007416)2.80929525
137exploration behavior (GO:0035640)2.80512443
138regulation of macrophage derived foam cell differentiation (GO:0010743)2.80294579
139fatty acid elongation (GO:0030497)2.79573632
140locomotory exploration behavior (GO:0035641)2.79429422
141positive regulation of neurotransmitter transport (GO:0051590)2.79033854
142regulation of protein localization to plasma membrane (GO:1903076)2.78078875
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77957968
144beta-amyloid metabolic process (GO:0050435)2.77874848
145regulation of female receptivity (GO:0045924)2.76562454
146regulation of glutamate secretion (GO:0014048)2.76318770
147regulation of neurotransmitter levels (GO:0001505)2.75461160
148regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.75333259
149regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.75333259
150calcium ion-dependent exocytosis (GO:0017156)2.75112784
151negative regulation of thymocyte apoptotic process (GO:0070244)2.74862736
152regulation of neurotransmitter secretion (GO:0046928)2.74823074
153negative regulation of heart rate (GO:0010459)2.74277560
154action potential (GO:0001508)2.74174827
155positive regulation of membrane potential (GO:0045838)2.73203674
156negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.73178595
157fusion of sperm to egg plasma membrane (GO:0007342)2.72134055
158long-term memory (GO:0007616)2.71637635
159positive regulation of amino acid transport (GO:0051957)2.71368457
160regulation of cAMP-dependent protein kinase activity (GO:2000479)2.71343062
161regulation of coagulation (GO:0050818)2.70943829
162female mating behavior (GO:0060180)2.70650406
163intraspecies interaction between organisms (GO:0051703)2.70346828
164social behavior (GO:0035176)2.70346828
165positive regulation of cell junction assembly (GO:1901890)2.69282211
166positive regulation of focal adhesion assembly (GO:0051894)2.69282211
167negative regulation of neural precursor cell proliferation (GO:2000178)2.68989273
168learning (GO:0007612)2.67359242
169purinergic receptor signaling pathway (GO:0035587)2.67288958
170negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.67286781
171negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66711208
172synaptic vesicle endocytosis (GO:0048488)2.66214488
173regulation of synaptic plasticity (GO:0048167)2.66118857
174membrane hyperpolarization (GO:0060081)2.65232272
175behavioral response to cocaine (GO:0048148)2.64761286
176detection of mechanical stimulus involved in sensory perception (GO:0050974)2.64101506
177positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.63951186
178regulation of neurotransmitter transport (GO:0051588)2.62508852
179leukocyte tethering or rolling (GO:0050901)2.62118022
180activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.61961316
181positive regulation of synaptic transmission (GO:0050806)2.61588727
182positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61587273
183behavioral defense response (GO:0002209)2.60207711
184behavioral fear response (GO:0001662)2.60207711
185positive regulation of muscle hypertrophy (GO:0014742)2.59462963
186positive regulation of cardiac muscle hypertrophy (GO:0010613)2.59462963
187glycosphingolipid biosynthetic process (GO:0006688)2.58711904
188regulation of memory T cell differentiation (GO:0043380)2.58349215
189righting reflex (GO:0060013)2.58227648
190regulation of early endosome to late endosome transport (GO:2000641)2.57498138
191positive regulation of leukocyte degranulation (GO:0043302)2.57014916
192regulation of establishment of protein localization to plasma membrane (GO:0090003)2.56111250
193endothelium development (GO:0003158)2.55766565
194activation of protein kinase A activity (GO:0034199)2.55599060
195fibrinolysis (GO:0042730)2.55577156
196fibril organization (GO:0097435)2.55401251
197termination of G-protein coupled receptor signaling pathway (GO:0038032)2.54659527
198positive regulation of granulocyte differentiation (GO:0030854)2.52882949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71788432
2GBX2_23144817_ChIP-Seq_PC3_Human4.20896489
3SCL_19346495_ChIP-Seq_HPC-7_Human3.52172289
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.41181792
5* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.36618839
6TAF15_26573619_Chip-Seq_HEK293_Human3.27358648
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89841725
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84947808
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.75599129
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70792310
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58204722
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55274942
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.52030613
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40725434
15GATA1_19941826_ChIP-Seq_K562_Human2.40707619
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37397609
17* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.35317436
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34879090
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33948043
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31663154
21GATA2_19941826_ChIP-Seq_K562_Human2.27202070
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26538113
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21343398
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21343398
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.20889349
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.19724129
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.17418351
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13427868
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13123866
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12317611
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09680005
32P300_19829295_ChIP-Seq_ESCs_Human2.09478617
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08915250
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08197060
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08022586
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07803580
37SMAD4_21799915_ChIP-Seq_A2780_Human2.06960907
38GATA1_22025678_ChIP-Seq_K562_Human2.04832689
39TP63_17297297_ChIP-ChIP_HaCaT_Human2.04743005
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.99119430
41REST_21632747_ChIP-Seq_MESCs_Mouse1.98751430
42AR_21572438_ChIP-Seq_LNCaP_Human1.96769521
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.94716703
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.84290248
45* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.84211332
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.82417681
47VDR_22108803_ChIP-Seq_LS180_Human1.81513668
48SPI1_23127762_ChIP-Seq_K562_Human1.79894520
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79742677
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78730795
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78730795
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78441222
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.76558516
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.73867102
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.73838071
56* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73365414
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72827505
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71523927
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71359578
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70974555
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.69462648
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67998929
63FUS_26573619_Chip-Seq_HEK293_Human1.67556072
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65265992
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64392211
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63801643
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62496306
68* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61989959
69* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61989959
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60964226
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58630186
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58168768
73AR_25329375_ChIP-Seq_VCAP_Human1.57464958
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57147523
75* SOX2_20726797_ChIP-Seq_SW620_Human1.56784580
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56582760
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53367332
78IGF1R_20145208_ChIP-Seq_DFB_Human1.52993011
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.52901299
80* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50798380
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.49913285
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49586138
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.49489782
84RNF2_27304074_Chip-Seq_NSC_Mouse1.48699944
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46573909
86DROSHA_22980978_ChIP-Seq_HELA_Human1.46322212
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46284156
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.45500766
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.45481936
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43433892
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42729141
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42409837
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39312776
94GATA1_19941827_ChIP-Seq_MEL86_Mouse1.38572916
95ZNF274_21170338_ChIP-Seq_K562_Hela1.38196051
96TP53_18474530_ChIP-ChIP_U2OS_Human1.38059465
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37675303
98* CJUN_26792858_Chip-Seq_BT549_Human1.36459163
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35408685
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34488181
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34198339
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33676344
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33657469
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33426919
105* RUNX1_22412390_ChIP-Seq_EML_Mouse1.31842284
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31730597
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.30733780
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.30517708
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.29083255
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28985187
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.28358567
112ER_23166858_ChIP-Seq_MCF-7_Human1.27000029
113RUNX_20019798_ChIP-Seq_JUKART_Human1.26823316
114AHR_22903824_ChIP-Seq_MCF-7_Human1.26645546
115STAT3_23295773_ChIP-Seq_U87_Human1.25517339
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.24660451
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24134819
118* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22835320
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22073959
120TP63_23658742_ChIP-Seq_EP156T_Human1.21684023
121RUNX2_22187159_ChIP-Seq_PCA_Human1.21666909
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20891953
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19254962
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19209764
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19179555
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18865470
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16963481
128BCAT_22108803_ChIP-Seq_LS180_Human1.16857534
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16455341
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16451182
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16047057
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15824563
133ESR1_20079471_ChIP-ChIP_T-47D_Human1.15670719
134PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15541113
135RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15397808
136* JUN_21703547_ChIP-Seq_K562_Human1.15178912
137E2F1_18555785_Chip-Seq_ESCs_Mouse1.14770122
138FLI1_27457419_Chip-Seq_LIVER_Mouse1.14574435
139TCF4_23295773_ChIP-Seq_U87_Human1.14050870
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.13995863
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13915971
142P53_22387025_ChIP-Seq_ESCs_Mouse1.13764050
143CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13494443
144CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11510272
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11478107
146KDM2B_26808549_Chip-Seq_REH_Human1.11006792
147GATA4_25053715_ChIP-Seq_YYC3_Human1.10364638
148EWS_26573619_Chip-Seq_HEK293_Human1.10118168
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09870854
150P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09094418
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08683748
152HTT_18923047_ChIP-ChIP_STHdh_Human1.07323136
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06767401
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06187575
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05205676
156CMYC_18555785_Chip-Seq_ESCs_Mouse1.04980770
157BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04818030
158NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04755493
159TP53_16413492_ChIP-PET_HCT116_Human1.03747096
160SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03516335
161TCF4_22108803_ChIP-Seq_LS180_Human1.03041281
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02247220
163CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02068969
164* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01697755
165KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00973868
166TAL1_26923725_Chip-Seq_HPCs_Mouse0.99940224
167SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99703597
168CBP_20019798_ChIP-Seq_JUKART_Human0.99395856
169IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99395856
170SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98663574
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98445068
172TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98445068
173BRD4_25478319_ChIP-Seq_HGPS_Human0.98412827
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98207669
175STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97862043
176CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96719597
177RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94908287
178KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89089610
179TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88892963
180SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87764588
181WT1_19549856_ChIP-ChIP_CCG9911_Human0.85006569
182EGR1_19374776_ChIP-ChIP_THP-1_Human0.84116520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005464_abnormal_platelet_physiology7.65912594
2MP0001968_abnormal_touch/_nociception4.77471223
3MP0002736_abnormal_nociception_after4.72382533
4MP0003880_abnormal_central_pattern4.51001154
5MP0004859_abnormal_synaptic_plasticity3.95983952
6MP0002735_abnormal_chemical_nociception3.70156204
7MP0000465_gastrointestinal_hemorrhage3.54855612
8MP0003566_abnormal_cell_adhesion3.32965043
9MP0003724_increased_susceptibility_to3.20854841
10MP0003635_abnormal_synaptic_transmissio3.19706853
11MP0009745_abnormal_behavioral_response3.14397297
12MP0008004_abnormal_stomach_pH2.94990775
13MP0002734_abnormal_mechanical_nocicepti2.85951721
14MP0002064_seizures2.75472630
15MP0009046_muscle_twitch2.70348172
16MP0001986_abnormal_taste_sensitivity2.68955224
17MP0004270_analgesia2.62318314
18MP0002063_abnormal_learning/memory/cond2.61944397
19MP0006276_abnormal_autonomic_nervous2.61659214
20MP0001188_hyperpigmentation2.54971436
21MP0002272_abnormal_nervous_system2.51836931
22MP0001501_abnormal_sleep_pattern2.50328819
23MP0002572_abnormal_emotion/affect_behav2.49932234
24MP0002733_abnormal_thermal_nociception2.45329191
25MP0001970_abnormal_pain_threshold2.42109337
26MP0002796_impaired_skin_barrier2.36567016
27MP0004510_myositis2.29028834
28MP0005083_abnormal_biliary_tract2.28783138
29MP0004084_abnormal_cardiac_muscle2.18149448
30MP0010386_abnormal_urinary_bladder2.16491268
31MP0002822_catalepsy2.14242839
32MP0005501_abnormal_skin_physiology2.10501349
33MP0005646_abnormal_pituitary_gland2.10370743
34MP0004947_skin_inflammation2.04932840
35MP0002067_abnormal_sensory_capabilities2.00010545
36MP0002877_abnormal_melanocyte_morpholog1.99372581
37MP0001851_eye_inflammation1.99100571
38MP0001486_abnormal_startle_reflex1.96228767
39MP0003828_pulmonary_edema1.95287464
40MP0003453_abnormal_keratinocyte_physiol1.95263476
41MP0000343_altered_response_to1.93213896
42MP0001664_abnormal_digestion1.92924055
43MP0001984_abnormal_olfaction1.86228767
44MP0001440_abnormal_grooming_behavior1.85978535
45MP0003122_maternal_imprinting1.83908661
46MP0005275_abnormal_skin_tensile1.81459259
47MP0003787_abnormal_imprinting1.79170362
48MP0003300_gastrointestinal_ulcer1.74388468
49MP0010352_gastrointestinal_tract_polyps1.74064665
50MP0005423_abnormal_somatic_nervous1.73700949
51MP0000383_abnormal_hair_follicle1.71195709
52MP0002876_abnormal_thyroid_physiology1.66001557
53MP0002557_abnormal_social/conspecific_i1.65071296
54MP0010155_abnormal_intestine_physiology1.63261241
55MP0002184_abnormal_innervation1.60262007
56MP0010678_abnormal_skin_adnexa1.56996920
57MP0001905_abnormal_dopamine_level1.56897011
58MP0001529_abnormal_vocalization1.56660345
59MP0003091_abnormal_cell_migration1.55457060
60MP0000579_abnormal_nail_morphology1.54490085
61MP0005023_abnormal_wound_healing1.53291253
62MP0003656_abnormal_erythrocyte_physiolo1.52013923
63MP0004924_abnormal_behavior1.51899677
64MP0005386_behavior/neurological_phenoty1.51899677
65MP0000230_abnormal_systemic_arterial1.51314976
66MP0001879_abnormal_lymphatic_vessel1.50238776
67MP0009780_abnormal_chondrocyte_physiolo1.48487832
68MP0000858_altered_metastatic_potential1.47226869
69MP0004036_abnormal_muscle_relaxation1.46475590
70MP0004142_abnormal_muscle_tone1.43206910
71MP0003191_abnormal_cellular_cholesterol1.41991939
72MP0001835_abnormal_antigen_presentation1.33247059
73MP0003303_peritoneal_inflammation1.32913615
74MP0005058_abnormal_lysosome_morphology1.31657203
75MP0005645_abnormal_hypothalamus_physiol1.29500467
76MP0010234_abnormal_vibrissa_follicle1.25166202
77MP0002837_dystrophic_cardiac_calcinosis1.24766906
78MP0000249_abnormal_blood_vessel1.23807726
79MP0004130_abnormal_muscle_cell1.23276181
80MP0004264_abnormal_extraembryonic_tissu1.22835553
81MP0008775_abnormal_heart_ventricle1.22628321
82MP0008569_lethality_at_weaning1.19250323
83MP0001216_abnormal_epidermal_layer1.18015152
84MP0004808_abnormal_hematopoietic_stem1.17943575
85MP0004858_abnormal_nervous_system1.16782312
86MP0005409_darkened_coat_color1.14717749
87MP0005165_increased_susceptibility_to1.14699191
88MP0000778_abnormal_nervous_system1.12973494
89MP0005410_abnormal_fertilization1.08347052
90MP0002148_abnormal_hypersensitivity_rea1.07239575
91MP0002909_abnormal_adrenal_gland1.06804749
92MP0004811_abnormal_neuron_physiology1.06587151
93MP0001765_abnormal_ion_homeostasis1.05346172
94MP0003879_abnormal_hair_cell1.04659582
95MP0001849_ear_inflammation1.03459379
96MP0008872_abnormal_physiological_respon1.02889306
97MP0000015_abnormal_ear_pigmentation0.99464528
98MP0002882_abnormal_neuron_morphology0.99243529
99MP0002066_abnormal_motor_capabilities/c0.99077286
100MP0001663_abnormal_digestive_system0.96598380
101MP0004484_altered_response_of0.96337549
102MP0009763_increased_sensitivity_to0.95773191
103MP0000538_abnormal_urinary_bladder0.95522858
104MP0008260_abnormal_autophagy0.94043850
105MP0003866_abnormal_defecation0.93928102
106MP0001502_abnormal_circadian_rhythm0.93701258
107* MP0002398_abnormal_bone_marrow0.93696690
108MP0002009_preneoplasia0.92796959
109MP0001533_abnormal_skeleton_physiology0.92278913
110MP0002998_abnormal_bone_remodeling0.92012105
111MP0006054_spinal_hemorrhage0.91584013
112MP0003329_amyloid_beta_deposits0.91028764
113MP0004381_abnormal_hair_follicle0.90738947
114MP0005666_abnormal_adipose_tissue0.90427929
115MP0005397_hematopoietic_system_phenotyp0.89354031
116MP0001545_abnormal_hematopoietic_system0.89354031
117MP0002163_abnormal_gland_morphology0.89322468
118MP0005000_abnormal_immune_tolerance0.89052236
119MP0003705_abnormal_hypodermis_morpholog0.87154960
120MP0000955_abnormal_spinal_cord0.87151138
121MP0003436_decreased_susceptibility_to0.85853019
122MP0005394_taste/olfaction_phenotype0.85461834
123MP0005499_abnormal_olfactory_system0.85461834
124MP0001963_abnormal_hearing_physiology0.84536964
125MP0001177_atelectasis0.83563086
126MP0005164_abnormal_response_to0.82149434
127MP0005551_abnormal_eye_electrophysiolog0.82053895
128MP0003763_abnormal_thymus_physiology0.80641498
129MP0001191_abnormal_skin_condition0.79930222
130MP0006138_congestive_heart_failure0.79894713
131MP0003183_abnormal_peptide_metabolism0.79360971
132MP0004883_abnormal_blood_vessel0.78899406
133MP0004147_increased_porphyrin_level0.78832233
134MP0005379_endocrine/exocrine_gland_phen0.78555867
135MP0005621_abnormal_cell_physiology0.77287324
136MP0000569_abnormal_digit_pigmentation0.76728293
137MP0000681_abnormal_thyroid_gland0.76722286
138MP0004742_abnormal_vestibular_system0.76061450
139MP0009765_abnormal_xenobiotic_induced0.76052282
140MP0003633_abnormal_nervous_system0.74177126
141MP0002069_abnormal_eating/drinking_beha0.71420675
142MP0002166_altered_tumor_susceptibility0.71080075
143MP0002098_abnormal_vibrissa_morphology0.70892840
144MP0009931_abnormal_skin_appearance0.70785709
145MP0000377_abnormal_hair_follicle0.70475133
146MP0005535_abnormal_body_temperature0.70321770
147MP0003448_altered_tumor_morphology0.69772677
148MP0008874_decreased_physiological_sensi0.69286774
149MP0004782_abnormal_surfactant_physiolog0.67574893
150MP0000427_abnormal_hair_cycle0.67245024
151MP0002229_neurodegeneration0.66794081
152MP0010329_abnormal_lipoprotein_level0.66471779
153MP0009379_abnormal_foot_pigmentation0.66361709
154MP0000467_abnormal_esophagus_morphology0.66198648
155MP0004185_abnormal_adipocyte_glucose0.66047520
156MP0005310_abnormal_salivary_gland0.65705178
157MP0000631_abnormal_neuroendocrine_gland0.65112715
158MP0000516_abnormal_urinary_system0.65044170
159MP0005367_renal/urinary_system_phenotyp0.65044170
160MP0005084_abnormal_gallbladder_morpholo0.64686730
161MP0004134_abnormal_chest_morphology0.64415083
162MP0002277_abnormal_respiratory_mucosa0.64201613
163MP0005381_digestive/alimentary_phenotyp0.63684719
164MP0002060_abnormal_skin_morphology0.63252868
165MP0000627_abnormal_mammary_gland0.62877036
166MP0002128_abnormal_blood_circulation0.62875990
167MP0000372_irregular_coat_pigmentation0.62457763
168MP0003950_abnormal_plasma_membrane0.62184569
169MP0001270_distended_abdomen0.61792479
170MP0009697_abnormal_copulation0.60805042
171MP0003638_abnormal_response/metabolism_0.59303214
172MP0002752_abnormal_somatic_nervous0.58757613
173MP0003631_nervous_system_phenotype0.58743716
174MP0010771_integument_phenotype0.57274663
175MP0003121_genomic_imprinting0.56695615
176MP0002638_abnormal_pupillary_reflex0.56308206
177MP0000026_abnormal_inner_ear0.56298889
178MP0004085_abnormal_heartbeat0.56277666
179MP0001943_abnormal_respiration0.54927929
180MP0000566_synostosis0.53621256
181MP0002152_abnormal_brain_morphology0.52774019
182MP0000751_myopathy0.52683201
183MP0008789_abnormal_olfactory_epithelium0.50247753

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.45179714
2Increased mean platelet volume (HP:0011877)9.32248170
3Menorrhagia (HP:0000132)9.07117752
4Abnormal platelet volume (HP:0011876)8.70912262
5Focal motor seizures (HP:0011153)7.89032515
6Petechiae (HP:0000967)7.88153916
7Purpura (HP:0000979)6.87861840
8Epistaxis (HP:0000421)6.43281250
9Gingival bleeding (HP:0000225)6.34727078
10Impaired platelet aggregation (HP:0003540)5.50540629
11Abnormal platelet function (HP:0011869)5.50540629
12Febrile seizures (HP:0002373)5.46864731
13Atonic seizures (HP:0010819)5.46744598
14Focal seizures (HP:0007359)4.94079332
15Epileptic encephalopathy (HP:0200134)4.47317134
16Abnormal hair whorl (HP:0010721)4.35865022
17Myokymia (HP:0002411)4.17846696
18Absence seizures (HP:0002121)4.11435214
19Hyperlipoproteinemia (HP:0010980)3.90313219
20Visual hallucinations (HP:0002367)3.84872909
21Spontaneous hematomas (HP:0007420)3.76888211
22Acanthocytosis (HP:0001927)3.66473626
23Dialeptic seizures (HP:0011146)3.59806617
24Poikilocytosis (HP:0004447)3.56297880
25Progressive cerebellar ataxia (HP:0002073)3.55774072
26Dyschromatopsia (HP:0007641)3.50422181
27Generalized tonic-clonic seizures (HP:0002069)3.49495883
28Hyperventilation (HP:0002883)3.47302272
29Abnormality of the common coagulation pathway (HP:0010990)3.36080333
30Hypothermia (HP:0002045)3.34236662
31Papillary thyroid carcinoma (HP:0002895)3.31589892
32Bruising susceptibility (HP:0000978)3.29625535
33Failure to thrive in infancy (HP:0001531)3.11734028
34Conjunctival telangiectasia (HP:0000524)3.05652197
35Gait imbalance (HP:0002141)3.04328550
36Progressive inability to walk (HP:0002505)3.03000693
37Anxiety (HP:0000739)2.89900584
38Congenital primary aphakia (HP:0007707)2.87692553
39Broad-based gait (HP:0002136)2.78819852
40Polyphagia (HP:0002591)2.78499867
41Termporal pattern (HP:0011008)2.75827897
42Insidious onset (HP:0003587)2.75827897
43Acute necrotizing encephalopathy (HP:0006965)2.73969426
44Medial flaring of the eyebrow (HP:0010747)2.72306786
45Progressive macrocephaly (HP:0004481)2.69036753
46Abnormality of the vasculature of the conjunctiva (HP:0008054)2.67491037
47Nephrogenic diabetes insipidus (HP:0009806)2.67241923
48Abnormal auditory evoked potentials (HP:0006958)2.66962194
49Genital tract atresia (HP:0001827)2.56090230
50Poor suck (HP:0002033)2.53731978
51Drooling (HP:0002307)2.53181856
52Excessive salivation (HP:0003781)2.53181856
53Pheochromocytoma (HP:0002666)2.52443741
54Osteolytic defects of the hand bones (HP:0009699)2.46711115
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.46711115
56Amblyopia (HP:0000646)2.44903694
57Abnormal mitochondria in muscle tissue (HP:0008316)2.44456747
58Inability to walk (HP:0002540)2.43405913
59Esotropia (HP:0000565)2.41424951
60Narrow nasal bridge (HP:0000446)2.40384017
61Abnormal eating behavior (HP:0100738)2.39336825
62Neuroendocrine neoplasm (HP:0100634)2.37742658
63Limb dystonia (HP:0002451)2.37198497
64Vaginal atresia (HP:0000148)2.36742491
65Thick nail (HP:0001805)2.35609667
66Mitochondrial inheritance (HP:0001427)2.31581280
67Gaze-evoked nystagmus (HP:0000640)2.30152648
68Distal lower limb amyotrophy (HP:0008944)2.30075537
69Diplopia (HP:0000651)2.28689503
70Abnormality of binocular vision (HP:0011514)2.28689503
71Abnormal pupillary function (HP:0007686)2.27789553
72Generalized hypopigmentation of hair (HP:0011358)2.27521528
73Specific learning disability (HP:0001328)2.26657218
74Hypoventilation (HP:0002791)2.23623480
75Abnormal ciliary motility (HP:0012262)2.21560082
76Oligomenorrhea (HP:0000876)2.19658269
77Mitral stenosis (HP:0001718)2.18782186
78Thyroid carcinoma (HP:0002890)2.18708472
79Abnormality of pain sensation (HP:0010832)2.18693594
80Impaired pain sensation (HP:0007328)2.18693594
81Abnormality of nail color (HP:0100643)2.18124358
82Fetal akinesia sequence (HP:0001989)2.16662408
83Truncal ataxia (HP:0002078)2.15496645
84Erythema (HP:0010783)2.15096827
85Protruding tongue (HP:0010808)2.15069797
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.14789158
87Absent/shortened dynein arms (HP:0200106)2.14789158
88Sleep apnea (HP:0010535)2.14560796
89Ankyloglossia (HP:0010296)2.13701081
90Upper limb muscle weakness (HP:0003484)2.12511964
91Aortic aneurysm (HP:0004942)2.11492813
92Curly hair (HP:0002212)2.09326109
93Vascular calcification (HP:0004934)2.07381151
94Autoimmune hemolytic anemia (HP:0001890)2.05895673
95Poor coordination (HP:0002370)2.05777474
96Abnormality of salivation (HP:0100755)2.04959328
97Cardiovascular calcification (HP:0011915)2.03852473
98Blue irides (HP:0000635)2.03469758
99Joint swelling (HP:0001386)2.03138520
100Fair hair (HP:0002286)2.01759619
101Bradycardia (HP:0001662)2.01269702
102Psychosis (HP:0000709)2.00780611
103Absent speech (HP:0001344)2.00159393
104Male infertility (HP:0003251)1.99758678
105Hyperthyroidism (HP:0000836)1.99315930
106Epileptiform EEG discharges (HP:0011182)1.99271420
107Abnormality of the labia minora (HP:0012880)1.95486799
108Increased density of long bones (HP:0006392)1.95196457
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94825780
110Arterial thrombosis (HP:0004420)1.92213427
111Scanning speech (HP:0002168)1.90307085
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88821998
113Eczematoid dermatitis (HP:0000976)1.87293333
114Tetraparesis (HP:0002273)1.84629002
115Lower limb amyotrophy (HP:0007210)1.83502421
116Uterine leiomyosarcoma (HP:0002891)1.83153104
117Leiomyosarcoma (HP:0100243)1.83153104
118Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82689659
119Poor eye contact (HP:0000817)1.82586334
120Labial hypoplasia (HP:0000066)1.82554312
121Back pain (HP:0003418)1.82425504
122Acute encephalopathy (HP:0006846)1.81798578
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.81555512
124Paralysis (HP:0003470)1.80267613
125Abnormality of oral frenula (HP:0000190)1.80201423
126Testicular neoplasm (HP:0010788)1.80019680
127Abnormal respiratory epithelium morphology (HP:0012253)1.79551803
128Abnormal respiratory motile cilium morphology (HP:0005938)1.79551803
129Spontaneous abortion (HP:0005268)1.78941609
130Dyskinesia (HP:0100660)1.78052535
131Severe short stature (HP:0003510)1.77740813
132Alopecia of scalp (HP:0002293)1.77136394
133Interstitial pulmonary disease (HP:0006530)1.76278908
134EEG with generalized epileptiform discharges (HP:0011198)1.75782540
135Optic disc pallor (HP:0000543)1.75766144
136Right ventricular cardiomyopathy (HP:0011663)1.75271429
137Increased CSF lactate (HP:0002490)1.74075046
138Depression (HP:0000716)1.73932992
139Transitional cell carcinoma of the bladder (HP:0006740)1.72636775
140Ulnar claw (HP:0001178)1.72043470
141Cerebral inclusion bodies (HP:0100314)1.71399537
142Aplasia/Hypoplasia of the lens (HP:0008063)1.70959946
143Action tremor (HP:0002345)1.69957706
144Short tibia (HP:0005736)1.69716584
145Pancreatic fibrosis (HP:0100732)1.69503453
146Biliary tract neoplasm (HP:0100574)1.67170290
147Impaired vibration sensation in the lower limbs (HP:0002166)1.67146383
148Heterochromia iridis (HP:0001100)1.67033088
149Hepatocellular necrosis (HP:0001404)1.66434739
150Bladder carcinoma (HP:0002862)1.66418187
151Bladder neoplasm (HP:0009725)1.66418187
152Abnormal respiratory motile cilium physiology (HP:0012261)1.66243187
153Joint hemorrhage (HP:0005261)1.66041857
154Ventricular fibrillation (HP:0001663)1.66023932
155Milia (HP:0001056)1.65417035
156Autoamputation (HP:0001218)1.65088459
157Plantar hyperkeratosis (HP:0007556)1.64639755
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.64516290
159Dysautonomia (HP:0002459)1.64442214
160Palmoplantar hyperkeratosis (HP:0000972)1.61827192
161Ankle clonus (HP:0011448)1.61378217
162X-linked dominant inheritance (HP:0001423)1.60980747
163Thrombocytosis (HP:0001894)1.60900175
164Impaired social interactions (HP:0000735)1.60880121
165Abnormal social behavior (HP:0012433)1.60880121
166Abnormality of iron homeostasis (HP:0011031)1.60583568
167Onycholysis (HP:0001806)1.60305339
168Akinesia (HP:0002304)1.59937529
169Choroideremia (HP:0001139)1.59703958
170Renal tubular acidosis (HP:0001947)1.59376488
171Exotropia (HP:0000577)1.58130049
172Inappropriate behavior (HP:0000719)1.58113245
173Abnormality of incisor morphology (HP:0011063)1.58074161
174Dysmetria (HP:0001310)1.57340174
175Aortic dissection (HP:0002647)1.55596268
176Abnormality of macrophages (HP:0004311)1.55550388
177Nail dystrophy (HP:0008404)1.55471112
178Xanthomatosis (HP:0000991)1.54645094
179Tinnitus (HP:0000360)1.54503469
180Abnormality of the Achilles tendon (HP:0005109)1.50787950
181Absent frontal sinuses (HP:0002688)1.50240799
182Palmar hyperkeratosis (HP:0010765)1.49739106
183Decreased central vision (HP:0007663)1.49693481
184Increased IgE level (HP:0003212)1.49413335
185Myocardial infarction (HP:0001658)1.49065575
186Hepatosplenomegaly (HP:0001433)1.47343880
187Distal lower limb muscle weakness (HP:0009053)1.45958042
188Hyporeflexia of lower limbs (HP:0002600)1.45665619
189Arterial tortuosity (HP:0005116)1.42789413
190Glomerulosclerosis (HP:0000096)1.42319414
191Chest pain (HP:0100749)1.40691467
192Tongue fasciculations (HP:0001308)1.39546611
193Coarse hair (HP:0002208)1.39359766
194Dysostosis multiplex (HP:0000943)1.39285526
195Papilledema (HP:0001085)1.38405081
196Ridged nail (HP:0001807)1.38144400
197Abnormality of transition element cation homeostasis (HP:0011030)1.38032395
198Polycythemia (HP:0001901)1.37714372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.75361339
2NTRK34.16567978
3CASK3.91226371
4BMX3.29161544
5EPHA43.16123826
6MAP2K73.06142422
7RIPK42.90382286
8MAP3K42.72427303
9EIF2AK12.59509146
10EPHA22.51274358
11MAP3K92.44243554
12TEC2.40163526
13BTK2.32465547
14FRK2.29980679
15PIK3CG2.13145782
16NME12.10984203
17MINK11.95178833
18ZAP701.92983339
19MAP2K41.91955111
20TAOK31.87423155
21MST1R1.86223818
22GRK51.83638522
23STK31.79383559
24GRK61.74318791
25SCYL21.72977322
26CSF1R1.71566528
27TNIK1.71097215
28MST41.67450828
29ARAF1.65139580
30SYK1.62602569
31TNK21.60725937
32PLK21.55282179
33AKT31.54516534
34ILK1.51923833
35DAPK21.51298968
36DAPK11.50495796
37MAPKAPK31.49822829
38BMPR21.39381825
39MET1.35145105
40MUSK1.32021366
41NTRK11.31692727
42MAPK131.31358695
43IRAK31.31350510
44FER1.31279882
45PDGFRB1.31201560
46HCK1.27363886
47MAPKAPK51.26053792
48TSSK61.26043053
49BMPR1B1.24511404
50MAP3K61.22581257
51NTRK21.19337783
52MYLK1.19337780
53MAP3K21.18363603
54SGK21.14624484
55CDK191.14465807
56CAMK2A1.13519406
57EPHB11.13140530
58ADRBK21.09363276
59JAK11.07671411
60KSR21.06793859
61OXSR11.05776757
62FGR1.03932268
63PRKCE1.02628498
64MARK11.01275392
65FES1.00117565
66CDK50.99599532
67EPHA30.98795243
68SIK30.98675276
69LMTK20.96527888
70GRK70.93429556
71PRKCG0.92052554
72PDPK10.91446443
73PDK10.90036479
74PTK20.85773521
75MATK0.84907427
76SGK2230.84842019
77SGK4940.84842019
78IRAK10.83962239
79MAP2K30.83446658
80MAP2K10.83364557
81TRIM280.82280923
82ERBB40.80491629
83CAMK2B0.80010273
84MAP3K130.78169204
85PKN20.77904897
86PDGFRA0.77857967
87PNCK0.77705632
88CCNB10.77641594
89MAP3K30.77099932
90MAP3K50.74401647
91KSR10.74159000
92RPS6KA20.71820870
93PIK3CA0.71461915
94PAK10.68745194
95CAMK2D0.67826889
96YES10.66848918
97NEK60.64007295
98ERBB30.63925007
99CAMK1G0.62313545
100ERBB20.62255735
101CSK0.61961279
102SIK10.60553551
103ACVR1B0.59667667
104RAF10.59101747
105PAK20.58054878
106BCR0.57827111
107CDK80.57112631
108CSNK1G20.56875804
109SGK10.56574553
110JAK30.54930498
111JAK20.54766449
112IKBKB0.54628532
113SGK30.54544429
114MAP3K10.53036516
115LATS10.52747006
116FLT30.52514330
117CDK30.52461171
118PRPF4B0.52439372
119STK160.52014431
120STK240.51142336
121ADRBK10.51071365
122PRKD10.50170737
123STK390.49353401
124TAOK10.47997304
125TIE10.47825484
126PTK2B0.47617072
127MAP2K60.47571436
128ITK0.47430290
129FYN0.46579034
130BRSK20.46165063
131CAMKK20.45693509
132BRAF0.45401945
133CAMK2G0.45317500
134PRKACA0.45278763
135PINK10.45174686
136TAOK20.44754213
137PAK30.43295702
138IRAK20.43157261
139PDK20.43075908
140DAPK30.41378499
141LYN0.41175305
142PRKG20.40507754
143PRKCA0.39391155
144HIPK20.39106407
145CAMKK10.38835299
146STK380.37762891
147RPS6KB10.37392658
148PAK60.36796956
149PRKG10.35515300
150FGFR20.35045468
151FGFR30.34950998
152GRK10.34776998
153MKNK20.34621290
154NEK90.34395050
155TRPM70.33244133
156CDK140.33125487
157CAMK10.31418429
158DYRK1A0.30331438
159TRIB30.30330302
160PRKACG0.30302782
161RET0.30160140

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08053499
2Synaptic vesicle cycle_Homo sapiens_hsa047213.24051812
3Collecting duct acid secretion_Homo sapiens_hsa049663.15840335
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.71181439
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69051646
6Taste transduction_Homo sapiens_hsa047422.48215395
7GABAergic synapse_Homo sapiens_hsa047272.47187628
8Olfactory transduction_Homo sapiens_hsa047402.41604504
9Long-term potentiation_Homo sapiens_hsa047202.24063818
10Morphine addiction_Homo sapiens_hsa050322.21995065
11Circadian entrainment_Homo sapiens_hsa047132.20273870
12Amphetamine addiction_Homo sapiens_hsa050312.12747699
13ECM-receptor interaction_Homo sapiens_hsa045122.12291253
14Serotonergic synapse_Homo sapiens_hsa047262.10660672
15Oxidative phosphorylation_Homo sapiens_hsa001902.08734757
16Glutamatergic synapse_Homo sapiens_hsa047242.07913004
17Salivary secretion_Homo sapiens_hsa049702.04852973
18Vibrio cholerae infection_Homo sapiens_hsa051102.02233479
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.93619241
20Gastric acid secretion_Homo sapiens_hsa049711.86084887
21Dopaminergic synapse_Homo sapiens_hsa047281.83590779
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79416709
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78813102
24Long-term depression_Homo sapiens_hsa047301.66545822
25Insulin secretion_Homo sapiens_hsa049111.65331998
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64471747
27Calcium signaling pathway_Homo sapiens_hsa040201.64313422
28Renin secretion_Homo sapiens_hsa049241.61602557
29* Pancreatic secretion_Homo sapiens_hsa049721.58245708
30Alzheimers disease_Homo sapiens_hsa050101.47494140
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.43290476
32Cholinergic synapse_Homo sapiens_hsa047251.42954863
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41224957
34Hematopoietic cell lineage_Homo sapiens_hsa046401.41036747
35Pancreatic cancer_Homo sapiens_hsa052121.40642184
36Focal adhesion_Homo sapiens_hsa045101.35679860
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35492486
38Parkinsons disease_Homo sapiens_hsa050121.35440966
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.34738897
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33743961
41Endocytosis_Homo sapiens_hsa041441.32949602
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32550839
43Chemokine signaling pathway_Homo sapiens_hsa040621.32478245
44B cell receptor signaling pathway_Homo sapiens_hsa046621.32234472
45Non-small cell lung cancer_Homo sapiens_hsa052231.31034224
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30544644
47Cocaine addiction_Homo sapiens_hsa050301.30124142
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28702752
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25345019
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25042604
51Oxytocin signaling pathway_Homo sapiens_hsa049211.22890021
52Endometrial cancer_Homo sapiens_hsa052131.22149575
53Rheumatoid arthritis_Homo sapiens_hsa053231.21990738
54Shigellosis_Homo sapiens_hsa051311.19813499
55Renal cell carcinoma_Homo sapiens_hsa052111.19067214
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18782220
57GnRH signaling pathway_Homo sapiens_hsa049121.17871504
58Phototransduction_Homo sapiens_hsa047441.13346974
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13236759
60VEGF signaling pathway_Homo sapiens_hsa043701.11671470
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04637059
62Chronic myeloid leukemia_Homo sapiens_hsa052201.04564849
63Thyroid cancer_Homo sapiens_hsa052161.04088991
64Gap junction_Homo sapiens_hsa045401.02367246
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01479307
66Nitrogen metabolism_Homo sapiens_hsa009101.00568873
67Adherens junction_Homo sapiens_hsa045201.00220641
68Renin-angiotensin system_Homo sapiens_hsa046140.99894496
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99526294
70Cardiac muscle contraction_Homo sapiens_hsa042600.99088736
71Amoebiasis_Homo sapiens_hsa051460.98211622
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96351863
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.94204455
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93946156
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92639598
76T cell receptor signaling pathway_Homo sapiens_hsa046600.91617307
77Huntingtons disease_Homo sapiens_hsa050160.90589432
78Small cell lung cancer_Homo sapiens_hsa052220.89978015
79cAMP signaling pathway_Homo sapiens_hsa040240.89526526
80Type I diabetes mellitus_Homo sapiens_hsa049400.87791668
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85026136
82Melanogenesis_Homo sapiens_hsa049160.83952144
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82871070
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82800453
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82638194
86Estrogen signaling pathway_Homo sapiens_hsa049150.75957435
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75520248
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75487970
89Thyroid hormone synthesis_Homo sapiens_hsa049180.74711029
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73158887
91Acute myeloid leukemia_Homo sapiens_hsa052210.72056707
92Starch and sucrose metabolism_Homo sapiens_hsa005000.71271719
93African trypanosomiasis_Homo sapiens_hsa051430.69102929
94Proteoglycans in cancer_Homo sapiens_hsa052050.68900987
95ErbB signaling pathway_Homo sapiens_hsa040120.67338682
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.65941904
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.65869868
98Glycerolipid metabolism_Homo sapiens_hsa005610.65770851
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65330589
100Osteoclast differentiation_Homo sapiens_hsa043800.64644754
101Malaria_Homo sapiens_hsa051440.64024892
102Phagosome_Homo sapiens_hsa041450.63580824
103Protein digestion and absorption_Homo sapiens_hsa049740.62009075
104Hepatitis C_Homo sapiens_hsa051600.60656719
105Axon guidance_Homo sapiens_hsa043600.59347359
106Choline metabolism in cancer_Homo sapiens_hsa052310.58241587
107Prostate cancer_Homo sapiens_hsa052150.57802432
108Glioma_Homo sapiens_hsa052140.56004267
109Viral carcinogenesis_Homo sapiens_hsa052030.54976124
110Bladder cancer_Homo sapiens_hsa052190.54974119
111Mineral absorption_Homo sapiens_hsa049780.54260717
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53779970
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53742311
114Prolactin signaling pathway_Homo sapiens_hsa049170.53289801
115Ovarian steroidogenesis_Homo sapiens_hsa049130.51903654
116Insulin signaling pathway_Homo sapiens_hsa049100.49193095
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.48991273
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46161484
119Apoptosis_Homo sapiens_hsa042100.45707709
120MAPK signaling pathway_Homo sapiens_hsa040100.45579656
121Toxoplasmosis_Homo sapiens_hsa051450.45285161
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.45278378
123Linoleic acid metabolism_Homo sapiens_hsa005910.44927388
124Dilated cardiomyopathy_Homo sapiens_hsa054140.44732928
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.44288567
126Ras signaling pathway_Homo sapiens_hsa040140.43841577
127Sphingolipid metabolism_Homo sapiens_hsa006000.43755976
128FoxO signaling pathway_Homo sapiens_hsa040680.43644406
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43252307
130Rap1 signaling pathway_Homo sapiens_hsa040150.42020556
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.36942674
132Melanoma_Homo sapiens_hsa052180.36808244
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36237504
134Platelet activation_Homo sapiens_hsa046110.35994771
135Inositol phosphate metabolism_Homo sapiens_hsa005620.34731599
136Oocyte meiosis_Homo sapiens_hsa041140.33759789
137Ether lipid metabolism_Homo sapiens_hsa005650.33266354
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32233985
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31399071
140Type II diabetes mellitus_Homo sapiens_hsa049300.30959917
141Dorso-ventral axis formation_Homo sapiens_hsa043200.30728767
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26626910
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25029940
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.24350216
145Arachidonic acid metabolism_Homo sapiens_hsa005900.24286112
146Alcoholism_Homo sapiens_hsa050340.23762079
147Sulfur metabolism_Homo sapiens_hsa009200.23526342
148Wnt signaling pathway_Homo sapiens_hsa043100.21773919
149Glucagon signaling pathway_Homo sapiens_hsa049220.20856527
150Salmonella infection_Homo sapiens_hsa051320.18404612
151Regulation of autophagy_Homo sapiens_hsa041400.14095121
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13486745
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13088078

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