RAB28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rab subfamily of Ras-related small GTPases. The encoded protein may be involved in regulating intracellular trafficking. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 9 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.21765315
2CENP-A containing nucleosome assembly (GO:0034080)4.94195428
3chromatin remodeling at centromere (GO:0031055)4.87851881
4establishment of integrated proviral latency (GO:0075713)4.62336457
5histone exchange (GO:0043486)4.30964223
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.21866781
7regulation of meiosis I (GO:0060631)4.21748488
8synapsis (GO:0007129)4.17119651
9detection of calcium ion (GO:0005513)4.15568486
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.14936841
11kinetochore organization (GO:0051383)4.14543960
12negative regulation of meiosis (GO:0045835)4.13837084
13DNA replication-independent nucleosome assembly (GO:0006336)4.01408420
14DNA replication-independent nucleosome organization (GO:0034724)4.01408420
15centriole replication (GO:0007099)3.93365121
16regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.90524391
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.84375705
18regulation of cell communication by electrical coupling (GO:0010649)3.79875565
19DNA ligation (GO:0006266)3.79594113
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.70505621
21regulation of synaptic vesicle exocytosis (GO:2000300)3.70017856
22kinetochore assembly (GO:0051382)3.66991962
23establishment of viral latency (GO:0019043)3.64610644
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.63455175
25negative regulation of DNA recombination (GO:0045910)3.60013367
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.56644647
27synaptic vesicle maturation (GO:0016188)3.55440447
28neuronal action potential propagation (GO:0019227)3.53990949
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51286329
30regulation of mitotic spindle checkpoint (GO:1903504)3.51286329
31synaptic vesicle exocytosis (GO:0016079)3.50590274
32negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.50394181
33negative regulation of calcium ion transmembrane transport (GO:1903170)3.50394181
34vocalization behavior (GO:0071625)3.43160317
35sarcoplasmic reticulum calcium ion transport (GO:0070296)3.40543296
36regulation of synaptic vesicle transport (GO:1902803)3.38513676
37activation of protein kinase A activity (GO:0034199)3.36635207
38axoneme assembly (GO:0035082)3.33112047
39resolution of meiotic recombination intermediates (GO:0000712)3.31946846
40regulation of synapse structural plasticity (GO:0051823)3.31749847
41negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.29145357
42regulation of calcium ion transmembrane transporter activity (GO:1901019)3.28956044
43regulation of calcium ion transmembrane transport (GO:1903169)3.28956044
44replication fork processing (GO:0031297)3.27688561
45protein neddylation (GO:0045116)3.27010991
46cullin deneddylation (GO:0010388)3.26489075
47negative regulation of cation channel activity (GO:2001258)3.26112802
48tricarboxylic acid cycle (GO:0006099)3.23161000
49DNA double-strand break processing (GO:0000729)3.21749506
50potassium ion import (GO:0010107)3.21377485
51DNA damage response, detection of DNA damage (GO:0042769)3.18765344
52mitotic metaphase plate congression (GO:0007080)3.17951509
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17864026
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15608597
55succinate metabolic process (GO:0006105)3.14756766
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13755165
57positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.12440572
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11186110
59spermatid nucleus differentiation (GO:0007289)3.10704789
60regulation of double-strand break repair via homologous recombination (GO:0010569)3.10350845
61glutamate secretion (GO:0014047)3.09464160
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09135541
63spindle checkpoint (GO:0031577)3.06637681
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04131665
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04016101
66mitotic spindle checkpoint (GO:0071174)3.03715052
67locomotory exploration behavior (GO:0035641)3.03702925
68protein localization to synapse (GO:0035418)3.03082861
69non-recombinational repair (GO:0000726)3.03035942
70double-strand break repair via nonhomologous end joining (GO:0006303)3.03035942
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02081497
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02081497
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02081497
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.02081497
75negative regulation of sister chromatid segregation (GO:0033046)3.02081497
76ribosome assembly (GO:0042255)2.99012784
77positive regulation of vesicle fusion (GO:0031340)2.98541587
78positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98460932
79regulation of membrane repolarization (GO:0060306)2.98002636
80epithelial cilium movement (GO:0003351)2.97993574
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97741698
82regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96824266
83ATP-dependent chromatin remodeling (GO:0043044)2.96213533
84axonemal dynein complex assembly (GO:0070286)2.95781112
85metaphase plate congression (GO:0051310)2.94470881
86cell communication by electrical coupling (GO:0010644)2.93756790
87regulation of mitochondrial translation (GO:0070129)2.92780155
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92541649
89protein K6-linked ubiquitination (GO:0085020)2.92396859
90negative regulation of chromosome segregation (GO:0051985)2.91058081
91DNA strand elongation involved in DNA replication (GO:0006271)2.89649889
92mitotic spindle assembly checkpoint (GO:0007094)2.89536504
93neuron cell-cell adhesion (GO:0007158)2.89367186
94cellular potassium ion homeostasis (GO:0030007)2.88307801
95DNA replication-dependent nucleosome assembly (GO:0006335)2.87742191
96DNA replication-dependent nucleosome organization (GO:0034723)2.87742191
97membrane depolarization during action potential (GO:0086010)2.87234157
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86023750
99negative regulation of meiotic cell cycle (GO:0051447)2.85745794
100protein deneddylation (GO:0000338)2.85543724
101spindle assembly checkpoint (GO:0071173)2.85541420
102DNA strand elongation (GO:0022616)2.84802337
103regulation of voltage-gated calcium channel activity (GO:1901385)2.83810660
104regulation of glutamate receptor signaling pathway (GO:1900449)2.83687728
105cilium movement (GO:0003341)2.81241507
106regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.81173159
107neurotransmitter secretion (GO:0007269)2.81137568
108regulation of cation channel activity (GO:2001257)2.80288727
109negative regulation of nuclear division (GO:0051784)2.79974337
110regulation of acyl-CoA biosynthetic process (GO:0050812)2.79510229
111regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79457526
112regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79457526
113mitotic G2/M transition checkpoint (GO:0044818)2.78627993
114nucleotide-excision repair, DNA gap filling (GO:0006297)2.78526759
115COPI coating of Golgi vesicle (GO:0048205)2.77471401
116Golgi transport vesicle coating (GO:0048200)2.77471401
117regulation of cofactor metabolic process (GO:0051193)2.77293025
118regulation of coenzyme metabolic process (GO:0051196)2.77293025
119regulation of rhodopsin mediated signaling pathway (GO:0022400)2.77087768
120positive regulation of mitochondrial fission (GO:0090141)2.77014902
121regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.76215483
122postreplication repair (GO:0006301)2.76077000
123purine nucleobase biosynthetic process (GO:0009113)2.74852551
124regulation of type B pancreatic cell apoptotic process (GO:2000674)2.74741107
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.73976518
126histone mRNA metabolic process (GO:0008334)2.73946195
127vesicle transport along microtubule (GO:0047496)2.73710425
128DNA replication checkpoint (GO:0000076)2.72958963
129synaptic vesicle docking involved in exocytosis (GO:0016081)2.72383702
130centriole assembly (GO:0098534)2.72186802
131regulation of mitotic sister chromatid separation (GO:0010965)2.70941359
132regulation of mitotic sister chromatid segregation (GO:0033047)2.70941359
133regulation of sister chromatid segregation (GO:0033045)2.70941359
134protein localization to kinetochore (GO:0034501)2.69772524
135histone H2A acetylation (GO:0043968)2.69094258
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67502873
137rhodopsin mediated signaling pathway (GO:0016056)2.66852040
138regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.66297000
139telomere maintenance via semi-conservative replication (GO:0032201)2.66238246
140establishment of chromosome localization (GO:0051303)2.65962748
141mitotic sister chromatid cohesion (GO:0007064)2.65892182
142regulation of chromosome segregation (GO:0051983)2.65828245
143base-excision repair (GO:0006284)2.65544977
144regulation of protein kinase A signaling (GO:0010738)2.65309295
145mitotic recombination (GO:0006312)2.64992604
146protein localization to chromosome, centromeric region (GO:0071459)2.64423321
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63415264
148regulation of vesicle fusion (GO:0031338)2.63360819
149striatum development (GO:0021756)2.62671622
150chromosome organization involved in meiosis (GO:0070192)2.62293296
151mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.62186632
152negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62140749
153negative regulation of ligase activity (GO:0051352)2.62140749
154membrane repolarization (GO:0086009)2.62117949
155regulation of relaxation of muscle (GO:1901077)2.62105094
156microtubule depolymerization (GO:0007019)2.61681483
157transcription from mitochondrial promoter (GO:0006390)2.61189806
158regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.60848485
159plasma membrane repair (GO:0001778)2.60285626
160mitotic chromosome condensation (GO:0007076)2.60143107
161regulation of skeletal muscle contraction (GO:0014819)2.59455178
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59337260
163positive regulation of ligase activity (GO:0051351)2.58518814
164base-excision repair, AP site formation (GO:0006285)2.58370322
165regulation of neuronal synaptic plasticity (GO:0048168)2.58361379
166G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58001608
167membrane repolarization during action potential (GO:0086011)2.57478409
168negative regulation of mitosis (GO:0045839)2.57109930
169proline transport (GO:0015824)2.55946724
170regulation of spindle organization (GO:0090224)2.55047277
171intraciliary transport (GO:0042073)2.54935306
172somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54690243
173somatic hypermutation of immunoglobulin genes (GO:0016446)2.54690243
174regulation of sister chromatid cohesion (GO:0007063)2.54616093
175protein K11-linked ubiquitination (GO:0070979)2.54133483
1767-methylguanosine mRNA capping (GO:0006370)2.53851757
177mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53749214
178protein maturation by protein folding (GO:0022417)2.53467417
179regulation of long-term neuronal synaptic plasticity (GO:0048169)2.52426813
180innervation (GO:0060384)2.52342548
181regulation of potassium ion transmembrane transport (GO:1901379)2.52014756
182cilium or flagellum-dependent cell motility (GO:0001539)2.50325436
183sensory perception of smell (GO:0007608)2.49967996
184mating behavior (GO:0007617)2.47884045
185positive regulation of synapse maturation (GO:0090129)2.47460638
186calcium ion-dependent exocytosis (GO:0017156)2.46908053
187long-term memory (GO:0007616)2.46503618
188negative regulation of inclusion body assembly (GO:0090084)2.45811720
189positive regulation of potassium ion transport (GO:0043268)2.45685017
190negative regulation of ion transmembrane transporter activity (GO:0032413)2.45094873
191regulation of ion transmembrane transporter activity (GO:0032412)2.43530168
192neuron-neuron synaptic transmission (GO:0007270)2.43359092
193organelle transport along microtubule (GO:0072384)2.42662911
194chemosensory behavior (GO:0007635)2.42545237
195cerebellar Purkinje cell differentiation (GO:0021702)2.41948747
196NADH metabolic process (GO:0006734)2.41604299
197neuron recognition (GO:0008038)2.40848262
198positive regulation of cation channel activity (GO:2001259)2.40143227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29344008
2E2F7_22180533_ChIP-Seq_HELA_Human4.25784258
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91619290
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09862089
5GBX2_23144817_ChIP-Seq_PC3_Human3.08812727
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.07353208
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86643776
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.72431442
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71070541
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67411638
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.66826709
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59905678
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50154007
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49264688
15ELK1_19687146_ChIP-ChIP_HELA_Human2.44866178
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39351926
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.39221019
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35530417
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35051122
20ZNF274_21170338_ChIP-Seq_K562_Hela2.34464012
21DROSHA_22980978_ChIP-Seq_HELA_Human2.30871843
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27329953
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24738551
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24000616
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22621027
26IGF1R_20145208_ChIP-Seq_DFB_Human2.21078879
27REST_21632747_ChIP-Seq_MESCs_Mouse2.18326959
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16501180
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16501180
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12943755
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12040857
32JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10367270
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08945594
34RARB_27405468_Chip-Seq_BRAIN_Mouse2.08891971
35EWS_26573619_Chip-Seq_HEK293_Human2.07019050
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05364062
37VDR_22108803_ChIP-Seq_LS180_Human2.03894757
38MYC_18555785_ChIP-Seq_MESCs_Mouse2.03594761
39EZH2_27294783_Chip-Seq_ESCs_Mouse2.01197567
40VDR_23849224_ChIP-Seq_CD4+_Human2.01116243
41POU5F1_16153702_ChIP-ChIP_HESCs_Human2.00768278
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.97813238
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94966144
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92885770
45TAF15_26573619_Chip-Seq_HEK293_Human1.90269061
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86296800
47* REST_18959480_ChIP-ChIP_MESCs_Mouse1.86284518
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86081510
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84793967
50* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.84033216
51AR_21909140_ChIP-Seq_LNCAP_Human1.83404247
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82887342
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80447127
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.80219200
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77505861
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77042817
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74667516
58SMAD4_21799915_ChIP-Seq_A2780_Human1.73376735
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.72336933
60* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71668109
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68860785
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68417713
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65730147
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62316391
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.62032948
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60672877
67FOXP3_21729870_ChIP-Seq_TREG_Human1.56605936
68* EP300_21415370_ChIP-Seq_HL-1_Mouse1.55311670
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54753739
70* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54264840
71* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53783957
72* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52022553
73P300_19829295_ChIP-Seq_ESCs_Human1.51552204
74MYC_18940864_ChIP-ChIP_HL60_Human1.50811557
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49757348
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48965313
77DCP1A_22483619_ChIP-Seq_HELA_Human1.48744464
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47883767
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.47394953
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46613499
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46052754
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45278568
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43885608
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.43262354
85* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41664153
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41598297
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41526006
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.40853827
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35212953
90* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34226619
91* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33705062
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33626366
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31875795
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31791150
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29193773
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28392760
97TTF2_22483619_ChIP-Seq_HELA_Human1.28228189
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28188699
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27968434
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.27880050
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.26595473
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25863561
103AR_21572438_ChIP-Seq_LNCaP_Human1.24123103
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.23667825
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23203208
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21244855
107GABP_19822575_ChIP-Seq_HepG2_Human1.21036137
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.20473295
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19147926
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13375941
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13375941
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13328666
113EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12907508
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12645432
115AR_25329375_ChIP-Seq_VCAP_Human1.12400733
116IRF1_19129219_ChIP-ChIP_H3396_Human1.12118076
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11692924
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11544874
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10055626
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09189544
121RNF2_27304074_Chip-Seq_NSC_Mouse1.07776428
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.07349836
123* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07099832
124STAT3_23295773_ChIP-Seq_U87_Human1.06126937
125* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05393400
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05382074
127BCAT_22108803_ChIP-Seq_LS180_Human1.05310888
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05304863
129ER_23166858_ChIP-Seq_MCF-7_Human1.05095840
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03467262
131* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03416258
132RING1B_27294783_Chip-Seq_ESCs_Mouse1.03366528
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03240247
134MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03091610
135AR_19668381_ChIP-Seq_PC3_Human1.01873603
136TCF4_23295773_ChIP-Seq_U87_Human1.01773506
137CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01300151
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.01153374
139CBP_20019798_ChIP-Seq_JUKART_Human1.00798339
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00798339
141FUS_26573619_Chip-Seq_HEK293_Human1.00713211
142YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00309770
143* CBX2_27304074_Chip-Seq_ESCs_Mouse1.00255712
144TRIM28_21343339_ChIP-Seq_HEK293_Human0.99729628
145* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99688375
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.99610572
147RUNX2_22187159_ChIP-Seq_PCA_Human0.99334506
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98190177
149* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96997835
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96426045
151TP53_18474530_ChIP-ChIP_U2OS_Human0.96276584
152CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96218015
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95455409
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95455409
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95227999
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.95041159
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94604126
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93861157
159WT1_19549856_ChIP-ChIP_CCG9911_Human0.92977647
160* SOX9_26525672_Chip-Seq_HEART_Mouse0.92414021
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91085470
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90805508
163ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90629796
164GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90451613
165E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90412248
166TCF4_22108803_ChIP-Seq_LS180_Human0.88832710
167NFE2_27457419_Chip-Seq_LIVER_Mouse0.88348311
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.87383627
169JUN_21703547_ChIP-Seq_K562_Human0.86334331
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.85859449
171P53_22387025_ChIP-Seq_ESCs_Mouse0.85803114
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.85113575
173AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84124965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.85515529
2MP0003136_yellow_coat_color3.79219634
3MP0004859_abnormal_synaptic_plasticity3.71447863
4MP0008058_abnormal_DNA_repair3.52535213
5MP0010094_abnormal_chromosome_stability3.30290478
6MP0003880_abnormal_central_pattern3.14303886
7MP0008877_abnormal_DNA_methylation3.08233829
8MP0000751_myopathy3.07975131
9MP0004145_abnormal_muscle_electrophysio3.01687769
10MP0003693_abnormal_embryo_hatching2.76602673
11MP0000372_irregular_coat_pigmentation2.64498102
12MP0000013_abnormal_adipose_tissue2.62607929
13MP0003635_abnormal_synaptic_transmissio2.59145270
14MP0009780_abnormal_chondrocyte_physiolo2.51137726
15MP0001984_abnormal_olfaction2.50662161
16MP0003646_muscle_fatigue2.47049296
17MP0004270_analgesia2.44760321
18MP0004215_abnormal_myocardial_fiber2.43291158
19MP0002909_abnormal_adrenal_gland2.42498063
20MP0008057_abnormal_DNA_replication2.38077404
21MP0003111_abnormal_nucleus_morphology2.37287778
22MP0003077_abnormal_cell_cycle2.30282958
23MP0008932_abnormal_embryonic_tissue2.24199924
24MP0004036_abnormal_muscle_relaxation2.20431768
25MP0004957_abnormal_blastocyst_morpholog2.19210867
26MP0005423_abnormal_somatic_nervous2.18478969
27MP0005551_abnormal_eye_electrophysiolog2.13802613
28MP0008789_abnormal_olfactory_epithelium2.13152080
29MP0006072_abnormal_retinal_apoptosis2.12610553
30MP0002063_abnormal_learning/memory/cond2.02367099
31MP0002272_abnormal_nervous_system2.00082770
32MP0002064_seizures1.95152652
33MP0006292_abnormal_olfactory_placode1.95033511
34MP0000749_muscle_degeneration1.91883407
35MP0009745_abnormal_behavioral_response1.90703844
36MP0001293_anophthalmia1.87500190
37MP0005646_abnormal_pituitary_gland1.86989104
38MP0003121_genomic_imprinting1.86272152
39MP0003283_abnormal_digestive_organ1.84575827
40MP0000747_muscle_weakness1.83919017
41MP0002734_abnormal_mechanical_nocicepti1.77109965
42MP0001968_abnormal_touch/_nociception1.76684935
43MP0004084_abnormal_cardiac_muscle1.73229271
44MP0009046_muscle_twitch1.72867044
45MP0002751_abnormal_autonomic_nervous1.71270285
46MP0010386_abnormal_urinary_bladder1.69598010
47MP0005645_abnormal_hypothalamus_physiol1.68610941
48MP0001188_hyperpigmentation1.68431874
49MP0008995_early_reproductive_senescence1.64279971
50MP0003718_maternal_effect1.63773911
51MP0004043_abnormal_pH_regulation1.61723925
52MP0005620_abnormal_muscle_contractility1.60261009
53MP0001501_abnormal_sleep_pattern1.59247743
54MP0002572_abnormal_emotion/affect_behav1.59213057
55MP0003786_premature_aging1.55999589
56MP0005248_abnormal_Harderian_gland1.55576225
57MP0005253_abnormal_eye_physiology1.54966332
58MP0001929_abnormal_gametogenesis1.50306627
59MP0003567_abnormal_fetal_cardiomyocyte1.49967275
60MP0002210_abnormal_sex_determination1.46403889
61MP0004484_altered_response_of1.44890814
62MP0006035_abnormal_mitochondrial_morpho1.44375438
63MP0005084_abnormal_gallbladder_morpholo1.42357554
64MP0003937_abnormal_limbs/digits/tail_de1.41259991
65MP0004130_abnormal_muscle_cell1.41188566
66MP0003890_abnormal_embryonic-extraembry1.39134444
67MP0001502_abnormal_circadian_rhythm1.36527560
68MP0002067_abnormal_sensory_capabilities1.36450032
69MP0002102_abnormal_ear_morphology1.35975236
70MP0004233_abnormal_muscle_weight1.34989190
71MP0002735_abnormal_chemical_nociception1.34070168
72MP0002234_abnormal_pharynx_morphology1.33373165
73MP0002106_abnormal_muscle_physiology1.32864962
74MP0002822_catalepsy1.32379660
75MP0001986_abnormal_taste_sensitivity1.32260899
76MP0003137_abnormal_impulse_conducting1.31590937
77MP0001440_abnormal_grooming_behavior1.30711901
78MP0002233_abnormal_nose_morphology1.28529766
79MP0008569_lethality_at_weaning1.27724964
80MP0002736_abnormal_nociception_after1.26699029
81MP0004133_heterotaxia1.26194739
82MP0001145_abnormal_male_reproductive1.24984249
83MP0000653_abnormal_sex_gland1.24551291
84MP0002972_abnormal_cardiac_muscle1.22957442
85MP0002184_abnormal_innervation1.22406522
86MP0005330_cardiomyopathy1.21685556
87MP0004924_abnormal_behavior1.20912973
88MP0005386_behavior/neurological_phenoty1.20912973
89MP0001970_abnormal_pain_threshold1.20305288
90MP0005369_muscle_phenotype1.20000388
91MP0004087_abnormal_muscle_fiber1.19692583
92MP0001486_abnormal_startle_reflex1.19238463
93MP0003122_maternal_imprinting1.18807647
94MP0006276_abnormal_autonomic_nervous1.18128462
95MP0002557_abnormal_social/conspecific_i1.17845327
96MP0002877_abnormal_melanocyte_morpholog1.17427682
97MP0001286_abnormal_eye_development1.17137283
98MP0002733_abnormal_thermal_nociception1.17062884
99MP0000759_abnormal_skeletal_muscle1.16975793
100MP0005171_absent_coat_pigmentation1.15985763
101MP0003698_abnormal_male_reproductive1.15951554
102MP0004811_abnormal_neuron_physiology1.14264605
103MP0002269_muscular_atrophy1.13988216
104MP0002638_abnormal_pupillary_reflex1.13752275
105MP0000350_abnormal_cell_proliferation1.12966898
106MP0004085_abnormal_heartbeat1.11723274
107MP0002938_white_spotting1.11663597
108MP0003183_abnormal_peptide_metabolism1.09859938
109MP0001299_abnormal_eye_distance/1.09472320
110MP0000003_abnormal_adipose_tissue1.08414042
111MP0002882_abnormal_neuron_morphology1.07406207
112MP0003119_abnormal_digestive_system1.06935499
113MP0010307_abnormal_tumor_latency1.06812202
114MP0009697_abnormal_copulation1.04478104
115MP0005391_vision/eye_phenotype1.02096090
116MP0002090_abnormal_vision1.02070493
117MP0000358_abnormal_cell_content/1.01881839
118MP0002095_abnormal_skin_pigmentation0.99653042
119MP0002085_abnormal_embryonic_tissue0.99510877
120MP0005535_abnormal_body_temperature0.98084040
121MP0002084_abnormal_developmental_patter0.97641105
122MP0004885_abnormal_endolymph0.97626796
123MP0000631_abnormal_neuroendocrine_gland0.96757145
124MP0003186_abnormal_redox_activity0.96358584
125MP0001119_abnormal_female_reproductive0.96172937
126MP0001944_abnormal_pancreas_morphology0.95372087
127MP0001697_abnormal_embryo_size0.94815418
128MP0002229_neurodegeneration0.94036186
129MP0010030_abnormal_orbit_morphology0.93966791
130MP0000049_abnormal_middle_ear0.93680879
131MP0001324_abnormal_eye_pigmentation0.93639574
132MP0005187_abnormal_penis_morphology0.93516255
133MP0005623_abnormal_meninges_morphology0.92963038
134MP0002653_abnormal_ependyma_morphology0.92142035
135MP0002282_abnormal_trachea_morphology0.91873321
136MP0003879_abnormal_hair_cell0.91772433
137MP0002697_abnormal_eye_size0.91413918
138MP0002066_abnormal_motor_capabilities/c0.91116079
139MP0002693_abnormal_pancreas_physiology0.90908630
140MP0000778_abnormal_nervous_system0.90176971
141MP0002078_abnormal_glucose_homeostasis0.89986839
142MP0004142_abnormal_muscle_tone0.89777014
143MP0002332_abnormal_exercise_endurance0.89730011
144MP0001529_abnormal_vocalization0.89491345
145MP0000750_abnormal_muscle_regeneration0.89306560
146MP0003221_abnormal_cardiomyocyte_apopto0.87976573
147MP0003634_abnormal_glial_cell0.87326320
148MP0006036_abnormal_mitochondrial_physio0.87163698
149MP0008775_abnormal_heart_ventricle0.86640867
150MP0004147_increased_porphyrin_level0.86568084
151MP0003861_abnormal_nervous_system0.86463417
152MP0001177_atelectasis0.85883639
153MP0008007_abnormal_cellular_replicative0.83661957
154MP0000955_abnormal_spinal_cord0.83084233
155MP0002277_abnormal_respiratory_mucosa0.82672140
156MP0003633_abnormal_nervous_system0.81022477
157MP0009703_decreased_birth_body0.80871353
158MP0003195_calcinosis0.80523033
159MP0000647_abnormal_sebaceous_gland0.80202139
160MP0003329_amyloid_beta_deposits0.78815749
161MP0005499_abnormal_olfactory_system0.78132559
162MP0005394_taste/olfaction_phenotype0.78132559
163MP0005195_abnormal_posterior_eye0.77236011
164MP0001672_abnormal_embryogenesis/_devel0.76427694
165MP0005380_embryogenesis_phenotype0.76427694
166MP0001730_embryonic_growth_arrest0.75515719
167MP0004197_abnormal_fetal_growth/weight/0.74231322
168MP0002161_abnormal_fertility/fecundity0.74150753
169MP0000537_abnormal_urethra_morphology0.73689939
170MP0000383_abnormal_hair_follicle0.72803715
171MP0002111_abnormal_tail_morphology0.70709450
172MP0000313_abnormal_cell_death0.69302775
173MP0002092_abnormal_eye_morphology0.69243956
174MP0002752_abnormal_somatic_nervous0.66935841
175MP0003755_abnormal_palate_morphology0.66384090

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.00969652
2Focal motor seizures (HP:0011153)3.96730474
3Visual hallucinations (HP:0002367)3.72921005
4Exercise-induced muscle cramps (HP:0003710)3.66590605
5Degeneration of anterior horn cells (HP:0002398)3.66257789
6Abnormality of the anterior horn cell (HP:0006802)3.66257789
7Muscle hypertrophy of the lower extremities (HP:0008968)3.65929735
8Calf muscle hypertrophy (HP:0008981)3.52508442
9* Central scotoma (HP:0000603)3.51885260
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.49338678
11Abnormal respiratory motile cilium physiology (HP:0012261)3.44708028
12Myoglobinuria (HP:0002913)3.23757665
13Pheochromocytoma (HP:0002666)3.23658176
14Abnormal ciliary motility (HP:0012262)3.22287439
15Atrophy/Degeneration involving motor neurons (HP:0007373)3.15587441
16True hermaphroditism (HP:0010459)3.10302724
17Abnormality of the labia minora (HP:0012880)3.09950071
18Hyperinsulinemic hypoglycemia (HP:0000825)3.04635372
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.02883842
20Abnormality of chromosome stability (HP:0003220)3.00228387
21Abnormal mitochondria in muscle tissue (HP:0008316)2.96494716
22Amyotrophic lateral sclerosis (HP:0007354)2.93384957
23Intestinal atresia (HP:0011100)2.92516689
24Cortical dysplasia (HP:0002539)2.90879518
25Bony spicule pigmentary retinopathy (HP:0007737)2.89705420
26Supernumerary spleens (HP:0009799)2.86760118
27Rhinitis (HP:0012384)2.84856988
28Acute necrotizing encephalopathy (HP:0006965)2.82262718
29Neuroendocrine neoplasm (HP:0100634)2.80889152
30Atonic seizures (HP:0010819)2.80035466
31Abnormal lung lobation (HP:0002101)2.73112858
32Abnormality of the calf musculature (HP:0001430)2.68734210
33Focal seizures (HP:0007359)2.62311635
34Myotonia (HP:0002486)2.61379445
35Prolonged QT interval (HP:0001657)2.59336579
36Ketoacidosis (HP:0001993)2.58949352
37* Scotoma (HP:0000575)2.58184795
38Meckel diverticulum (HP:0002245)2.57710504
39Absence seizures (HP:0002121)2.54882481
40Pancreatic cysts (HP:0001737)2.51356464
41Postaxial foot polydactyly (HP:0001830)2.51184523
42Abnormality of midbrain morphology (HP:0002418)2.50491873
43Molar tooth sign on MRI (HP:0002419)2.50491873
44Chronic bronchitis (HP:0004469)2.50074811
45Progressive macrocephaly (HP:0004481)2.49467660
46Epileptic encephalopathy (HP:0200134)2.48264270
47Medial flaring of the eyebrow (HP:0010747)2.47903219
48Preaxial hand polydactyly (HP:0001177)2.47240671
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.43801597
50Gait imbalance (HP:0002141)2.43602837
51Hyperglycinemia (HP:0002154)2.43186755
52Abnormal rod and cone electroretinograms (HP:0008323)2.41420731
53Abnormality of the ileum (HP:0001549)2.41356225
54Anencephaly (HP:0002323)2.39740334
55Duodenal stenosis (HP:0100867)2.38282059
56Small intestinal stenosis (HP:0012848)2.38282059
57Retinal dysplasia (HP:0007973)2.37952084
58Congenital primary aphakia (HP:0007707)2.36601308
59* Abnormality of macular pigmentation (HP:0008002)2.36576361
60Anxiety (HP:0000739)2.35371095
61Abnormality of the duodenum (HP:0002246)2.33590177
62Shoulder girdle muscle weakness (HP:0003547)2.33100075
63Congenital stationary night blindness (HP:0007642)2.33080629
64Median cleft lip (HP:0000161)2.33029890
65Left ventricular hypertrophy (HP:0001712)2.32980891
66Postaxial hand polydactyly (HP:0001162)2.32179391
67Abnormality of the lower motor neuron (HP:0002366)2.32089760
68Hypoplastic pelvis (HP:0008839)2.31422232
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29559548
70Abnormality of alanine metabolism (HP:0010916)2.29559548
71Hyperalaninemia (HP:0003348)2.29559548
72Myokymia (HP:0002411)2.28165210
73Sudden death (HP:0001699)2.27903880
74Broad foot (HP:0001769)2.27672340
75Nephronophthisis (HP:0000090)2.26478133
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.23845972
77Absent/shortened dynein arms (HP:0200106)2.23845972
78Muscle fiber splitting (HP:0003555)2.22869145
79Palpitations (HP:0001962)2.22020345
80Abnormal EKG (HP:0003115)2.21639257
81Muscle fiber inclusion bodies (HP:0100299)2.21057567
82Oligodactyly (hands) (HP:0001180)2.20771611
83Abnormal respiratory epithelium morphology (HP:0012253)2.19873298
84Abnormal respiratory motile cilium morphology (HP:0005938)2.19873298
85Acute encephalopathy (HP:0006846)2.19218497
86Generalized tonic-clonic seizures (HP:0002069)2.19023473
87Chromsome breakage (HP:0040012)2.18961415
88Ulnar deviation of the wrist (HP:0003049)2.17798703
89Rimmed vacuoles (HP:0003805)2.17765501
90Sloping forehead (HP:0000340)2.17137316
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16800681
92Type 1 muscle fiber predominance (HP:0003803)2.15526391
93Atrial fibrillation (HP:0005110)2.14462393
94EMG: myopathic abnormalities (HP:0003458)2.14330020
95Poor coordination (HP:0002370)2.14236280
96Insulin-resistant diabetes mellitus (HP:0000831)2.10768395
97Muscle stiffness (HP:0003552)2.10671261
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09538987
99Degeneration of the lateral corticospinal tracts (HP:0002314)2.09538987
100Nephrogenic diabetes insipidus (HP:0009806)2.09351203
101Gastrointestinal atresia (HP:0002589)2.09208544
102Type II lissencephaly (HP:0007260)2.07958946
103Gonadotropin excess (HP:0000837)2.07607660
104Ventricular fibrillation (HP:0001663)2.07402535
105Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.07172386
106Increased hepatocellular lipid droplets (HP:0006565)2.06666789
107Abnormality of the musculature of the pelvis (HP:0001469)2.06161013
108Abnormality of the hip-girdle musculature (HP:0001445)2.06161013
109Primary atrial arrhythmia (HP:0001692)2.06053322
110Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.05983407
111Bifid tongue (HP:0010297)2.05506483
112Sclerocornea (HP:0000647)2.03778502
113Aplasia/Hypoplasia of the tongue (HP:0010295)2.03579600
114Optic disc pallor (HP:0000543)2.03055042
115Depression (HP:0000716)2.02962297
116Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02355650
117Increased variability in muscle fiber diameter (HP:0003557)1.99217528
118Volvulus (HP:0002580)1.98102978
119Rhabdomyosarcoma (HP:0002859)1.97471962
120Syncope (HP:0001279)1.96932243
121Febrile seizures (HP:0002373)1.96692529
122Dialeptic seizures (HP:0011146)1.96193725
123Split foot (HP:0001839)1.95460865
124Supraventricular tachycardia (HP:0004755)1.94965546
125Pelvic girdle muscle weakness (HP:0003749)1.94781750
126Occipital encephalocele (HP:0002085)1.94396916
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92984981
128Short tibia (HP:0005736)1.91590490
129Oculomotor apraxia (HP:0000657)1.91168152
130Short middle phalanx of the 5th finger (HP:0004220)1.90831887
131Medulloblastoma (HP:0002885)1.90648406
132Oligomenorrhea (HP:0000876)1.89889138
133Limb-girdle muscle atrophy (HP:0003797)1.89825664
134Triphalangeal thumb (HP:0001199)1.88052577
135Supraventricular arrhythmia (HP:0005115)1.88024635
136Progressive cerebellar ataxia (HP:0002073)1.87482544
137Septo-optic dysplasia (HP:0100842)1.86769892
138Abnormality of the preputium (HP:0100587)1.86503673
139Clubbing of toes (HP:0100760)1.86153180
140Hyporeflexia of lower limbs (HP:0002600)1.85117910
141Difficulty running (HP:0009046)1.84039021
142Specific learning disability (HP:0001328)1.82921622
143Type II diabetes mellitus (HP:0005978)1.82516902
144Mitochondrial inheritance (HP:0001427)1.81847289
145Adrenal hypoplasia (HP:0000835)1.81454615
146Anophthalmia (HP:0000528)1.80913008
147Truncal ataxia (HP:0002078)1.79281641
148Lipid accumulation in hepatocytes (HP:0006561)1.77684877
149Abnormality of the phalanges of the 5th finger (HP:0004213)1.77423854
150Exercise intolerance (HP:0003546)1.77407030
151Large for gestational age (HP:0001520)1.77106801
152Abnormality of methionine metabolism (HP:0010901)1.76961226
153Pancreatic fibrosis (HP:0100732)1.76370092
154Genital tract atresia (HP:0001827)1.76063855
155Abnormality of the renal medulla (HP:0100957)1.75967675
156Abnormality of skeletal muscle fiber size (HP:0012084)1.75434129
157Colon cancer (HP:0003003)1.75265759
158Broad alveolar ridges (HP:0000187)1.75008685
159Distal arthrogryposis (HP:0005684)1.74212574
160Oligodactyly (HP:0012165)1.74139011
161Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74129446
162Male pseudohermaphroditism (HP:0000037)1.73760405
163Dandy-Walker malformation (HP:0001305)1.73613794
164Increased CSF lactate (HP:0002490)1.73199704
165Freckling (HP:0001480)1.72654237
166Neoplasm of the peripheral nervous system (HP:0100007)1.72285978
167Retinitis pigmentosa (HP:0000510)1.72153950
168Vaginal atresia (HP:0000148)1.71987994
169Hepatocellular necrosis (HP:0001404)1.71647046
170Carpal bone hypoplasia (HP:0001498)1.71128353
171Hypoplastic left heart (HP:0004383)1.70056038
172Nemaline bodies (HP:0003798)1.69487020
173Chronic hepatic failure (HP:0100626)1.68147793
174Abnormality of the corticospinal tract (HP:0002492)1.67737466
175Papillary thyroid carcinoma (HP:0002895)1.67511071
176Agitation (HP:0000713)1.67351700
177Hyperkalemia (HP:0002153)1.66255123
178Hypercortisolism (HP:0001578)1.65942866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.65367749
2BCR2.96796380
3MAP3K122.81555912
4CAMKK22.80066907
5SRPK12.78483429
6BUB12.77110215
7PHKG22.74218702
8PHKG12.74218702
9TRIM282.73713253
10PRKD32.71290644
11MAP4K22.58052756
12EPHA42.52948209
13CDC72.51179498
14PLK42.42599962
15MAP3K42.34667348
16TTK2.27573793
17WEE12.13061309
18PDK32.04838363
19PDK42.04838363
20MAPK152.02992109
21PLK32.01968764
22TTN1.98261802
23ZAK1.96992869
24ERBB31.95330124
25MAP2K41.90483094
26PINK11.82538097
27OBSCN1.79477251
28DYRK31.78136810
29CAMKK11.77013879
30MAP2K71.75339622
31INSRR1.73476627
32DDR21.68793620
33MKNK11.68549491
34MAP3K91.68086969
35CSNK1G21.67403661
36MINK11.62016603
37NUAK11.61169558
38PBK1.60438464
39WNK41.59453637
40CASK1.58210605
41PAK61.58150975
42TSSK61.57243792
43VRK21.52366428
44KSR21.47784943
45PLK11.42308832
46RPS6KA41.41823371
47CSNK1G31.39576881
48EIF2AK31.36695780
49PAK31.36689958
50VRK11.33561703
51BRSK21.32156197
52PDK21.28960588
53PDGFRA1.28306893
54CCNB11.28271306
55NTRK11.24317168
56UHMK11.22870019
57NEK11.22725335
58CSNK1G11.21249572
59TNIK1.19915087
60DYRK21.19570253
61NME11.17819870
62PLK21.16741204
63BMPR1B1.16352074
64CAMK2D1.15430672
65ACVR1B1.13775315
66KSR11.13762832
67MST41.13288032
68CSNK1A1L1.12871969
69FER1.12135338
70DAPK21.11413395
71MUSK1.10970973
72CDK51.09004663
73MKNK21.06748047
74MAP3K101.06207003
75PRKCG1.02719992
76FRK1.01391772
77ATR1.01219504
78CAMK2A0.98992698
79RIPK40.98293008
80LMTK20.96610780
81TNK20.93740862
82PNCK0.91749168
83MAP3K20.91597507
84GRK50.91139929
85MARK10.90540343
86DMPK0.83660378
87ATM0.82881897
88CAMK2B0.82427774
89DAPK10.82353199
90GRK10.81872258
91PTK2B0.81035482
92TYRO30.80121917
93SIK30.79658685
94HIPK20.79380606
95PRKCH0.79128781
96SGK2230.76792133
97SGK4940.76792133
98STK160.75596761
99BMPR20.75464026
100EPHB20.74877157
101FES0.74200942
102ARAF0.73905663
103WNK30.73839999
104CDK60.73554933
105MYLK0.73368180
106ADRBK20.71456868
107AURKB0.71381550
108CDC42BPA0.70873291
109BRD40.70599939
110BRSK10.70511074
111RET0.69768204
112NEK20.68736858
113MAP3K10.67540987
114EIF2AK20.65242828
115LIMK10.64773006
116MAP3K50.64464622
117NTRK20.64461718
118RIPK10.64259683
119CHEK20.63769225
120STK240.62704070
121STK390.62425515
122CAMK1G0.62068771
123PRKCE0.61768186
124PASK0.60525709
125AURKA0.59746218
126CAMK2G0.59698457
127MAPK130.58050835
128CAMK40.58001969
129WNK10.57249311
130CDK140.57179076
131CAMK10.56599072
132FGR0.55439913
133MATK0.54900903
134BRAF0.54535660
135CDK190.54408592
136STK40.53782915
137SCYL20.53314636
138GRK70.53102611
139TRIB30.51571784
140STK38L0.51434742
141CDK180.49286953
142MAP2K10.49223703
143CDK150.47620821
144CDK30.47352080
145RPS6KA50.46272026
146PRKACA0.45198131
147ADRBK10.44621801
148BCKDK0.44224885
149DYRK1B0.43318142
150SGK20.42384570
151CHEK10.42020110
152EIF2AK10.41753023
153OXSR10.41651047
154SGK10.40308889
155CSNK2A10.39439435
156CAMK1D0.38963869
157CDK11A0.36644218
158YES10.35081332
159PKN10.35008480
160RAF10.34588060
161EPHA30.32824988
162STK30.31884503
163CSNK2A20.29558978
164CDK10.29355962
165PRKDC0.27329119
166TESK10.27140706

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.34643905
2Proteasome_Homo sapiens_hsa030503.32827961
3Non-homologous end-joining_Homo sapiens_hsa034503.30315748
4Phototransduction_Homo sapiens_hsa047443.19654273
5DNA replication_Homo sapiens_hsa030303.18395781
6Homologous recombination_Homo sapiens_hsa034403.07575027
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.88814154
8Base excision repair_Homo sapiens_hsa034102.77004505
9Olfactory transduction_Homo sapiens_hsa047402.75839976
10Fanconi anemia pathway_Homo sapiens_hsa034602.68864480
11Nucleotide excision repair_Homo sapiens_hsa034202.44417027
12Synaptic vesicle cycle_Homo sapiens_hsa047212.40583063
13Insulin secretion_Homo sapiens_hsa049112.34622506
14GABAergic synapse_Homo sapiens_hsa047272.27667794
15Basal transcription factors_Homo sapiens_hsa030222.26239569
16Circadian entrainment_Homo sapiens_hsa047132.24721554
17Cell cycle_Homo sapiens_hsa041102.21612334
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19788989
19RNA polymerase_Homo sapiens_hsa030202.10420682
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10070503
21Nicotine addiction_Homo sapiens_hsa050332.09590804
22Selenocompound metabolism_Homo sapiens_hsa004502.09421607
23Steroid biosynthesis_Homo sapiens_hsa001002.04615390
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04260727
25RNA transport_Homo sapiens_hsa030132.04069739
26Spliceosome_Homo sapiens_hsa030402.01230175
27Morphine addiction_Homo sapiens_hsa050321.97520938
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97236300
29Cardiac muscle contraction_Homo sapiens_hsa042601.96838832
30Oxidative phosphorylation_Homo sapiens_hsa001901.96828110
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96526133
32Long-term potentiation_Homo sapiens_hsa047201.95480949
33Fatty acid elongation_Homo sapiens_hsa000621.92219830
34Amphetamine addiction_Homo sapiens_hsa050311.91168770
35RNA degradation_Homo sapiens_hsa030181.90596524
36Dopaminergic synapse_Homo sapiens_hsa047281.88619986
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85691122
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80217169
39Parkinsons disease_Homo sapiens_hsa050121.72973391
40Gastric acid secretion_Homo sapiens_hsa049711.71112852
41Glutamatergic synapse_Homo sapiens_hsa047241.70466068
42Vibrio cholerae infection_Homo sapiens_hsa051101.67700458
43Taste transduction_Homo sapiens_hsa047421.64625702
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59970154
45Cholinergic synapse_Homo sapiens_hsa047251.53140707
46Salivary secretion_Homo sapiens_hsa049701.50294634
47Oxytocin signaling pathway_Homo sapiens_hsa049211.48917080
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45917754
49Alzheimers disease_Homo sapiens_hsa050101.45906244
50Folate biosynthesis_Homo sapiens_hsa007901.42865193
51Renin secretion_Homo sapiens_hsa049241.42620597
52Calcium signaling pathway_Homo sapiens_hsa040201.41851692
53Dilated cardiomyopathy_Homo sapiens_hsa054141.39105315
54Serotonergic synapse_Homo sapiens_hsa047261.38066617
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35490015
56Pyrimidine metabolism_Homo sapiens_hsa002401.33884361
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.30935768
58Cocaine addiction_Homo sapiens_hsa050301.27745222
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.27720668
60Collecting duct acid secretion_Homo sapiens_hsa049661.26409755
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23901717
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21905282
63Purine metabolism_Homo sapiens_hsa002301.21437190
64Protein export_Homo sapiens_hsa030601.21059282
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20322529
66Glucagon signaling pathway_Homo sapiens_hsa049221.19429585
67mRNA surveillance pathway_Homo sapiens_hsa030151.19362717
68One carbon pool by folate_Homo sapiens_hsa006701.15488329
69GnRH signaling pathway_Homo sapiens_hsa049121.15321111
70Long-term depression_Homo sapiens_hsa047301.15180699
71Gap junction_Homo sapiens_hsa045401.13513780
72Type II diabetes mellitus_Homo sapiens_hsa049301.13092634
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12749204
74Huntingtons disease_Homo sapiens_hsa050161.12480339
75Circadian rhythm_Homo sapiens_hsa047101.05357605
76cAMP signaling pathway_Homo sapiens_hsa040241.02087693
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01931797
78Ribosome_Homo sapiens_hsa030101.01638301
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00920264
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.99547266
81Thyroid hormone synthesis_Homo sapiens_hsa049180.96167680
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95295781
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94305016
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92779106
85Sulfur metabolism_Homo sapiens_hsa009200.91821541
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91507902
87Glutathione metabolism_Homo sapiens_hsa004800.90525661
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89749628
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89497430
90Estrogen signaling pathway_Homo sapiens_hsa049150.89320246
91Hedgehog signaling pathway_Homo sapiens_hsa043400.86967742
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84767366
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84597662
94Biosynthesis of amino acids_Homo sapiens_hsa012300.84062406
95Insulin signaling pathway_Homo sapiens_hsa049100.83440977
96Pancreatic secretion_Homo sapiens_hsa049720.82693924
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82582922
98p53 signaling pathway_Homo sapiens_hsa041150.81676505
99Regulation of autophagy_Homo sapiens_hsa041400.81037630
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80084688
101Pyruvate metabolism_Homo sapiens_hsa006200.78838743
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75738777
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75572641
104Oocyte meiosis_Homo sapiens_hsa041140.72936569
105Propanoate metabolism_Homo sapiens_hsa006400.71564023
106Melanogenesis_Homo sapiens_hsa049160.71176703
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71113716
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70605636
109Peroxisome_Homo sapiens_hsa041460.69075723
110Basal cell carcinoma_Homo sapiens_hsa052170.67685570
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65505247
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64361352
113Type I diabetes mellitus_Homo sapiens_hsa049400.62366301
114Fatty acid metabolism_Homo sapiens_hsa012120.61552338
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61535384
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60520877
117Glioma_Homo sapiens_hsa052140.60395449
118Metabolic pathways_Homo sapiens_hsa011000.59264741
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57573839
120Wnt signaling pathway_Homo sapiens_hsa043100.57436567
121Hippo signaling pathway_Homo sapiens_hsa043900.57298400
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55812276
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54279150
124Butanoate metabolism_Homo sapiens_hsa006500.54057640
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53838030
126TGF-beta signaling pathway_Homo sapiens_hsa043500.53465128
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52098133
128Insulin resistance_Homo sapiens_hsa049310.51265982
129Alcoholism_Homo sapiens_hsa050340.50567143
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49752573
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48644118
132Carbon metabolism_Homo sapiens_hsa012000.46611020
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.45623477
134AMPK signaling pathway_Homo sapiens_hsa041520.40858651
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40689814
136Axon guidance_Homo sapiens_hsa043600.40484067
137Dorso-ventral axis formation_Homo sapiens_hsa043200.40203663
138Phagosome_Homo sapiens_hsa041450.37838476
139MAPK signaling pathway_Homo sapiens_hsa040100.37097975
140VEGF signaling pathway_Homo sapiens_hsa043700.36752363
141Inositol phosphate metabolism_Homo sapiens_hsa005620.35962594
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35100258
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.34981837
144Tight junction_Homo sapiens_hsa045300.34778879
145ErbB signaling pathway_Homo sapiens_hsa040120.34389431
146Ovarian steroidogenesis_Homo sapiens_hsa049130.32251770
147beta-Alanine metabolism_Homo sapiens_hsa004100.32208981
148Prolactin signaling pathway_Homo sapiens_hsa049170.32061323
149Prion diseases_Homo sapiens_hsa050200.31668330
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30765376
151Galactose metabolism_Homo sapiens_hsa000520.29471949
152mTOR signaling pathway_Homo sapiens_hsa041500.29255735
153Pentose phosphate pathway_Homo sapiens_hsa000300.25134786
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.24292329
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21487927
156Epstein-Barr virus infection_Homo sapiens_hsa051690.18713441
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18469771
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16778682
159Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15316917
160Thyroid cancer_Homo sapiens_hsa052160.14203886
161N-Glycan biosynthesis_Homo sapiens_hsa005100.12702118
162Adherens junction_Homo sapiens_hsa045200.08266698
163Pentose and glucuronate interconversions_Homo sapiens_hsa000400.07945640
164Sphingolipid metabolism_Homo sapiens_hsa006000.07316620

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