ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	9.39038688
2	nucleobase catabolic process (GO:0046113)	7.46955511
3	postsynaptic membrane organization (GO:0001941)	4.67522055
4	neuron recognition (GO:0008038)	4.65765655
5	axonal fasciculation (GO:0007413)	4.58754543
6	gamma-aminobutyric acid transport (GO:0015812)	4.54317986
7	somite development (GO:0061053)	4.29846979
8	presynaptic membrane assembly (GO:0097105)	4.22969056
9	neuron cell-cell adhesion (GO:0007158)	4.13818237
10	glycosphingolipid biosynthetic process (GO:0006688)	4.12908619
11	positive regulation of mitochondrial fission (GO:0090141)	3.84785814
12	cell proliferation in forebrain (GO:0021846)	3.66008316
13	retinal ganglion cell axon guidance (GO:0031290)	3.62586762
14	nonmotile primary cilium assembly (GO:0035058)	3.54440831
15	presynaptic membrane organization (GO:0097090)	3.54002213
16	ADP metabolic process (GO:0046031)	3.18640581
17	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.17848927
18	substrate-independent telencephalic tangential migration (GO:0021826)	3.17848927
19	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.17547257
20	dentate gyrus development (GO:0021542)	3.16415470
21	intraciliary transport (GO:0042073)	3.15364908
22	vocalization behavior (GO:0071625)	3.14344364
23	cerebral cortex radially oriented cell migration (GO:0021799)	3.11762782
24	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	3.03296652
25	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.01132344
26	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.98784663
27	regulation of feeding behavior (GO:0060259)	2.95450105
28	central nervous system projection neuron axonogenesis (GO:0021952)	2.92351486
29	sympathetic nervous system development (GO:0048485)	2.88239170
30	segment specification (GO:0007379)	2.87315968
31	epithelial cilium movement (GO:0003351)	2.86785711
32	protein localization to synapse (GO:0035418)	2.84896444
33	limb bud formation (GO:0060174)	2.81504068
34	ganglion development (GO:0061548)	2.80370589
35	coenzyme catabolic process (GO:0009109)	2.79169003
36	synapse assembly (GO:0007416)	2.79048077
37	C4-dicarboxylate transport (GO:0015740)	2.79042437
38	neurotransmitter-gated ion channel clustering (GO:0072578)	2.77906507
39	pyrimidine dimer repair (GO:0006290)	2.76094683
40	transmission of nerve impulse (GO:0019226)	2.75846572
41	hippocampus development (GO:0021766)	2.73846342
42	DNA double-strand break processing (GO:0000729)	2.69629733
43	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.68708972
44	protein polyglutamylation (GO:0018095)	2.68553093
45	olfactory bulb development (GO:0021772)	2.68109699
46	sialylation (GO:0097503)	2.67931156
47	positive regulation of neurological system process (GO:0031646)	2.66836452
48	regulation of telomere maintenance (GO:0032204)	2.66123397
49	positive regulation of synapse assembly (GO:0051965)	2.64533331
50	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.64158546
51	cytoplasmic mRNA processing body assembly (GO:0033962)	2.63711783
52	forebrain neuron differentiation (GO:0021879)	2.62708365
53	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.59820201
54	layer formation in cerebral cortex (GO:0021819)	2.59191210
55	response to muscle activity (GO:0014850)	2.58805747
56	behavioral response to nicotine (GO:0035095)	2.58420916
57	regulation of mitochondrial fission (GO:0090140)	2.57705431
58	DNA damage response, detection of DNA damage (GO:0042769)	2.57175550
59	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.56841658
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.55744839
61	regulation of dendritic spine morphogenesis (GO:0061001)	2.53772384
62	regulation of synaptic vesicle transport (GO:1902803)	2.51201037
63	regulation of synapse assembly (GO:0051963)	2.50897201
64	cornea development in camera-type eye (GO:0061303)	2.50714530
65	peroxisome fission (GO:0016559)	2.50710405
66	inner ear receptor stereocilium organization (GO:0060122)	2.49610734
67	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	2.49381714
68	regulation of telomere maintenance via telomerase (GO:0032210)	2.49156640
69	ganglioside metabolic process (GO:0001573)	2.48790834
70	acrosome reaction (GO:0007340)	2.48388391
71	regulation of synapse structural plasticity (GO:0051823)	2.48298397
72	neuron fate determination (GO:0048664)	2.48209860
73	cell migration in hindbrain (GO:0021535)	2.47087254
74	cilium organization (GO:0044782)	2.47026185
75	microtubule depolymerization (GO:0007019)	2.46646836
76	otic vesicle formation (GO:0030916)	2.46591054
77	sequestering of actin monomers (GO:0042989)	2.46299289
78	ephrin receptor signaling pathway (GO:0048013)	2.45625277
79	cilium assembly (GO:0042384)	2.44721283
80	regulation of membrane repolarization (GO:0060306)	2.43651363
81	negative regulation of macrophage differentiation (GO:0045650)	2.43288984
82	cilium movement (GO:0003341)	2.42043915
83	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.42001791
84	retina layer formation (GO:0010842)	2.40312450
85	regulation of autophagic vacuole assembly (GO:2000785)	2.39540837
86	cilium morphogenesis (GO:0060271)	2.39285047
87	positive regulation of myoblast differentiation (GO:0045663)	2.37902689
88	auditory behavior (GO:0031223)	2.37752006
89	actin-mediated cell contraction (GO:0070252)	2.36927322
90	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.35881224
91	axon extension (GO:0048675)	2.35182474
92	protein K48-linked ubiquitination (GO:0070936)	2.34509966
93	forebrain neuron development (GO:0021884)	2.33940623
94	synaptic transmission, glutamatergic (GO:0035249)	2.33682424
95	glycine transport (GO:0015816)	2.33011563
96	short-term memory (GO:0007614)	2.32581727
97	dendritic spine morphogenesis (GO:0060997)	2.32316452
98	regulation of synaptic vesicle exocytosis (GO:2000300)	2.32170391
99	axonogenesis (GO:0007409)	2.32143969
100	central nervous system neuron axonogenesis (GO:0021955)	2.31804950

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.32999071
2	GBX2_23144817_ChIP-Seq_PC3_Human	4.27729626
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.68599509
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.44673382
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05681446
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.84311584
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80771487
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61426553
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57234533
10	VDR_22108803_ChIP-Seq_LS180_Human	2.47474684
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.41345893
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39514653
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.34885667
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.26304687
15	FUS_26573619_Chip-Seq_HEK293_Human	2.25633509
16	RNF2_27304074_Chip-Seq_NSC_Mouse	2.20936248
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.20091681
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19624179
19	EWS_26573619_Chip-Seq_HEK293_Human	2.17517730
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16217591
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.09851986
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03692411
23	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.94498813
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93743565
25	P300_19829295_ChIP-Seq_ESCs_Human	1.88674156
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.83444221
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.76429209
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74132994
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.71796202
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70867081
31	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.64928379
32	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.63966274
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.61782796
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60511530
35	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.56708192
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55217857
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.53614873
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53614873
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51782480
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.51706079
41	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51139396
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45647193
43	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.44539397
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44099464
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40772494
46	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.40455716
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39038057
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37954328
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37624725
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37624725
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37020040
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36049954
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34508777
54	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.33615896
55	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.33615896
56	STAT3_23295773_ChIP-Seq_U87_Human	1.32784581
57	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.30569183
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.30142985
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30038162
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.29604302
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29128153
62	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.28928719
63	AR_25329375_ChIP-Seq_VCAP_Human	1.26977551
64	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26070054
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25346743
66	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.23384131
67	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.22574869
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21930509
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.20075031
70	TCF4_23295773_ChIP-Seq_U87_Human	1.18634151
71	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.17744076
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16606502
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16178476
74	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.15397417
75	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.15042886
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.14089299
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09300641
78	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08578651
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.08472031
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08261590
81	TP53_22573176_ChIP-Seq_HFKS_Human	1.08243785
82	NCOR_22424771_ChIP-Seq_293T_Human	1.07197179
83	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06982926
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06453089
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05856987
86	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.05680308
87	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05530199
88	SOX9_26525672_Chip-Seq_HEART_Mouse	1.02970919
89	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.02266414
90	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01125138
91	MYC_18940864_ChIP-ChIP_HL60_Human	1.01060555
92	JUN_21703547_ChIP-Seq_K562_Human	0.98708791
93	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.97125615
94	TP53_18474530_ChIP-ChIP_U2OS_Human	0.96461714
95	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.93816802
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90971990
97	AR_19668381_ChIP-Seq_PC3_Human	0.90315017
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.89502782
99	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.89378021
100	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.89204013

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.93269859
2	MP0003880_abnormal_central_pattern	3.38967255
3	MP0002653_abnormal_ependyma_morphology	3.38103848
4	MP0008789_abnormal_olfactory_epithelium	2.85142537
5	MP0003122_maternal_imprinting	2.80248298
6	MP0005499_abnormal_olfactory_system	2.78568465
7	MP0005394_taste/olfaction_phenotype	2.78568465
8	MP0002822_catalepsy	2.67042929
9	MP0002102_abnormal_ear_morphology	2.53007257
10	MP0000778_abnormal_nervous_system	2.46575510
11	MP0001529_abnormal_vocalization	2.41215737
12	MP0004859_abnormal_synaptic_plasticity	2.34060368
13	MP0000749_muscle_degeneration	2.29238825
14	MP0006276_abnormal_autonomic_nervous	2.20037030
15	MP0003136_yellow_coat_color	2.14611654
16	MP0003787_abnormal_imprinting	2.11375001
17	MP0002837_dystrophic_cardiac_calcinosis	2.05213216
18	MP0003635_abnormal_synaptic_transmissio	1.91765749
19	MP0008877_abnormal_DNA_methylation	1.79582481
20	MP0002272_abnormal_nervous_system	1.71461260
21	MP0001486_abnormal_startle_reflex	1.69246831
22	MP0002063_abnormal_learning/memory/cond	1.67636127
23	MP0000569_abnormal_digit_pigmentation	1.63238971
24	MP0003121_genomic_imprinting	1.61279691
25	MP0001984_abnormal_olfaction	1.56808994
26	MP0004145_abnormal_muscle_electrophysio	1.55807764
27	MP0004270_analgesia	1.53222408
28	MP0009745_abnormal_behavioral_response	1.51977860
29	MP0000955_abnormal_spinal_cord	1.45223484
30	MP0000049_abnormal_middle_ear	1.41733924
31	MP0002184_abnormal_innervation	1.41233977
32	MP0006072_abnormal_retinal_apoptosis	1.38146636
33	MP0002736_abnormal_nociception_after	1.37039617
34	MP0005423_abnormal_somatic_nervous	1.35595678
35	MP0004142_abnormal_muscle_tone	1.35444525
36	MP0005248_abnormal_Harderian_gland	1.35285502
37	MP0001968_abnormal_touch/_nociception	1.33822396
38	MP0008995_early_reproductive_senescence	1.33694949
39	MP0002882_abnormal_neuron_morphology	1.33550403
40	MP0001188_hyperpigmentation	1.32639757
41	MP0002752_abnormal_somatic_nervous	1.30186844
42	MP0003385_abnormal_body_wall	1.28340478
43	MP0002638_abnormal_pupillary_reflex	1.28316228
44	MP0004084_abnormal_cardiac_muscle	1.26144073
45	MP0000534_abnormal_ureter_morphology	1.24857968
46	MP0002733_abnormal_thermal_nociception	1.20880742
47	MP0002064_seizures	1.20653139
48	MP0002572_abnormal_emotion/affect_behav	1.20121295
49	MP0005253_abnormal_eye_physiology	1.19704756
50	MP0005367_renal/urinary_system_phenotyp	1.18554346
51	MP0000516_abnormal_urinary_system	1.18554346
52	MP0002233_abnormal_nose_morphology	1.18458803
53	MP0009046_muscle_twitch	1.15256995
54	MP0004811_abnormal_neuron_physiology	1.14985152
55	MP0005187_abnormal_penis_morphology	1.14540163
56	MP0005551_abnormal_eye_electrophysiolog	1.14109953
57	MP0002067_abnormal_sensory_capabilities	1.13367686
58	MP0002557_abnormal_social/conspecific_i	1.12883986
59	MP0002152_abnormal_brain_morphology	1.11723549
60	MP0001177_atelectasis	1.11495105
61	MP0003755_abnormal_palate_morphology	1.11058805
62	MP0001502_abnormal_circadian_rhythm	1.08194728
63	MP0003646_muscle_fatigue	1.07910514
64	MP0004215_abnormal_myocardial_fiber	1.07478329
65	MP0002234_abnormal_pharynx_morphology	1.07453565
66	MP0003942_abnormal_urinary_system	1.06639783
67	MP0001970_abnormal_pain_threshold	1.06432408
68	MP0004924_abnormal_behavior	1.06382415
69	MP0005386_behavior/neurological_phenoty	1.06382415
70	MP0003861_abnormal_nervous_system	1.04909327
71	MP0002735_abnormal_chemical_nociception	1.02634086
72	MP0000751_myopathy	0.98333034
73	MP0005195_abnormal_posterior_eye	0.98326232
74	MP0001293_anophthalmia	0.97708100
75	MP0001286_abnormal_eye_development	0.97283624
76	MP0002751_abnormal_autonomic_nervous	0.97112644
77	MP0004133_heterotaxia	0.95058122
78	MP0002066_abnormal_motor_capabilities/c	0.93991266
79	MP0001485_abnormal_pinna_reflex	0.93363249
80	MP0003937_abnormal_limbs/digits/tail_de	0.91589930
81	MP0002734_abnormal_mechanical_nocicepti	0.91112638
82	MP0002160_abnormal_reproductive_system	0.89554139
83	MP0000631_abnormal_neuroendocrine_gland	0.86388631
84	MP0008775_abnormal_heart_ventricle	0.85627683
85	MP0005620_abnormal_muscle_contractility	0.82894656
86	MP0002269_muscular_atrophy	0.80292685
87	MP0000759_abnormal_skeletal_muscle	0.79906423
88	MP0004085_abnormal_heartbeat	0.79823558
89	MP0000372_irregular_coat_pigmentation	0.79226994
90	MP0000013_abnormal_adipose_tissue	0.78033602
91	MP0000750_abnormal_muscle_regeneration	0.77109588
92	MP0002081_perinatal_lethality	0.76652411
93	MP0000026_abnormal_inner_ear	0.75731716
94	MP0003137_abnormal_impulse_conducting	0.75096407
95	MP0002106_abnormal_muscle_physiology	0.74331865
96	MP0004130_abnormal_muscle_cell	0.74101506
97	MP0003938_abnormal_ear_development	0.74030658
98	MP0003935_abnormal_craniofacial_develop	0.73876844
99	MP0001905_abnormal_dopamine_level	0.73755780
100	MP0008872_abnormal_physiological_respon	0.73625775

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.81307241
2	Pancreatic fibrosis (HP:0100732)	3.80977691
3	Drooling (HP:0002307)	3.49916729
4	True hermaphroditism (HP:0010459)	3.41125868
5	Focal seizures (HP:0007359)	3.22376828
6	Excessive salivation (HP:0003781)	3.18691013
7	Abnormality of midbrain morphology (HP:0002418)	3.11791467
8	Molar tooth sign on MRI (HP:0002419)	3.11791467
9	Abnormality of the labia minora (HP:0012880)	3.06626140
10	Gait imbalance (HP:0002141)	3.04585050
11	Ulnar claw (HP:0001178)	2.93827661
12	Medial flaring of the eyebrow (HP:0010747)	2.92118076
13	Nephrogenic diabetes insipidus (HP:0009806)	2.80403043
14	Submucous cleft hard palate (HP:0000176)	2.69581198
15	Congenital primary aphakia (HP:0007707)	2.68243938
16	Atonic seizures (HP:0010819)	2.66402479
17	Focal motor seizures (HP:0011153)	2.64276553
18	Rimmed vacuoles (HP:0003805)	2.58550235
19	Pachygyria (HP:0001302)	2.58340474
20	Nephronophthisis (HP:0000090)	2.56855108
21	Short tibia (HP:0005736)	2.53759693
22	Retinal dysplasia (HP:0007973)	2.51340165
23	Exercise-induced muscle cramps (HP:0003710)	2.48406743
24	Hip dysplasia (HP:0001385)	2.47585523
25	Polyphagia (HP:0002591)	2.46253365
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.45519581
27	Failure to thrive in infancy (HP:0001531)	2.43903952
28	Amyotrophic lateral sclerosis (HP:0007354)	2.43900246
29	Chronic hepatic failure (HP:0100626)	2.43561154
30	Hyperglycinemia (HP:0002154)	2.39260153
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33730197
32	Urinary urgency (HP:0000012)	2.29218539
33	Febrile seizures (HP:0002373)	2.28616099
34	CNS hypomyelination (HP:0003429)	2.22664537
35	Genital tract atresia (HP:0001827)	2.21259044
36	Poor coordination (HP:0002370)	2.21047450
37	Postaxial hand polydactyly (HP:0001162)	2.20599102
38	Cystic liver disease (HP:0006706)	2.19385689
39	Limb dystonia (HP:0002451)	2.17188742
40	Abnormality of the calf musculature (HP:0001430)	2.16970776
41	Dyskinesia (HP:0100660)	2.16707392
42	Lissencephaly (HP:0001339)	2.15870170
43	Postaxial foot polydactyly (HP:0001830)	2.13854039
44	Optic nerve hypoplasia (HP:0000609)	2.11088963
45	Fibular aplasia (HP:0002990)	2.09992387
46	Broad-based gait (HP:0002136)	2.07035543
47	Abnormality of the renal medulla (HP:0100957)	2.04298850
48	Inability to walk (HP:0002540)	2.03779894
49	Long clavicles (HP:0000890)	2.03202944
50	Urinary bladder sphincter dysfunction (HP:0002839)	2.02996041
51	Intestinal atresia (HP:0011100)	2.00951290
52	Narrow forehead (HP:0000341)	2.00251430
53	Hypoplasia of the brainstem (HP:0002365)	1.98998617
54	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.98998617
55	Generalized tonic-clonic seizures (HP:0002069)	1.98202999
56	Sclerocornea (HP:0000647)	1.96877913
57	Proximal amyotrophy (HP:0007126)	1.96804378
58	Median cleft lip (HP:0000161)	1.96308872
59	Cortical dysplasia (HP:0002539)	1.95770334
60	Patellar aplasia (HP:0006443)	1.94986295
61	Anencephaly (HP:0002323)	1.94636168
62	Tented upper lip vermilion (HP:0010804)	1.92153610
63	Vaginal atresia (HP:0000148)	1.91392476
64	Hyperventilation (HP:0002883)	1.89316284
65	Adrenal hypoplasia (HP:0000835)	1.88104509
66	Abnormality of the shoulder girdle musculature (HP:0001435)	1.87933464
67	Spastic tetraplegia (HP:0002510)	1.87697077
68	Rib fusion (HP:0000902)	1.85375204
69	Type 2 muscle fiber atrophy (HP:0003554)	1.84980068
70	Frequent falls (HP:0002359)	1.84786937
71	Aplasia/Hypoplasia of the patella (HP:0006498)	1.83782427
72	Volvulus (HP:0002580)	1.83745711
73	Scrotal hypoplasia (HP:0000046)	1.83739820
74	Neonatal respiratory distress (HP:0002643)	1.83219115
75	Epileptic encephalopathy (HP:0200134)	1.83163432
76	Supernumerary spleens (HP:0009799)	1.83142780
77	Vertebral clefting (HP:0008428)	1.82765100
78	Specific learning disability (HP:0001328)	1.80353615
79	Spastic gait (HP:0002064)	1.79908293
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74842542
81	Calf muscle hypertrophy (HP:0008981)	1.73288854
82	Abnormality of salivation (HP:0100755)	1.73229237
83	Hypoplastic pelvis (HP:0008839)	1.72674064
84	Protruding tongue (HP:0010808)	1.72667959
85	Hypsarrhythmia (HP:0002521)	1.71331999
86	Hypoplasia of the corpus callosum (HP:0002079)	1.70930447
87	Dialeptic seizures (HP:0011146)	1.70850434
88	Acute necrotizing encephalopathy (HP:0006965)	1.70373755
89	EEG with generalized epileptiform discharges (HP:0011198)	1.69435497
90	Akinesia (HP:0002304)	1.69425088
91	Epileptiform EEG discharges (HP:0011182)	1.68975827
92	Popliteal pterygium (HP:0009756)	1.68526868
93	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.68035085
94	Preaxial hand polydactyly (HP:0001177)	1.67961850
95	Hepatoblastoma (HP:0002884)	1.67954623
96	Abnormality of lateral ventricle (HP:0030047)	1.67298473
97	Methylmalonic acidemia (HP:0002912)	1.66820346
98	Gastrointestinal atresia (HP:0002589)	1.66716995
99	Shawl scrotum (HP:0000049)	1.65627090
100	Micropenis (HP:0000054)	1.65256405

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.03917080
2	MAP3K4	3.51411323
3	MAP2K7	3.37815697
4	PINK1	3.34051386
5	OBSCN	2.91092492
6	EPHA4	2.73271791
7	BCR	2.69329575
8	CASK	2.62412572
9	MAP4K2	2.37266470
10	SIK2	2.17758921
11	DYRK3	2.16544952
12	MAPK13	2.02806280
13	MARK2	1.82503370
14	EPHA3	1.80041300
15	WNK3	1.74508266
16	CSNK1A1L	1.70988364
17	DYRK2	1.70308414
18	NEK1	1.69540135
19	CSNK1G3	1.58260004
20	TRIM28	1.57956893
21	TAOK1	1.52215499
22	PIM2	1.51285518
23	BMPR1B	1.50850060
24	CSNK1G2	1.48700986
25	ADRBK2	1.47358248
26	PHKG1	1.47207603
27	PHKG2	1.47207603
28	MAP2K4	1.46207170
29	FRK	1.46056813
30	RPS6KA4	1.35065200
31	DYRK1B	1.28091621
32	CSNK1G1	1.21868109
33	BCKDK	1.16524986
34	NEK2	1.12758899
35	CCNB1	1.11013480
36	SRPK1	1.04820169
37	NTRK2	1.03636521
38	ERBB3	1.02568932
39	CLK1	1.01993409
40	CDK8	0.99896296
41	DYRK1A	0.99880661
42	SGK223	0.95133382
43	SGK494	0.95133382
44	PAK3	0.92226453
45	PAK6	0.88560532
46	MKNK2	0.88393281
47	NTRK3	0.86163689
48	BRD4	0.82482430
49	PKN1	0.81915792
50	EPHB2	0.81286363
51	PLK4	0.78783520
52	MARK3	0.78579690
53	CAMK4	0.78482073
54	SGK2	0.77859363
55	PRKCZ	0.77600850
56	CDK5	0.77408982
57	GRK1	0.76625070
58	MINK1	0.76320967
59	PLK2	0.75484197
60	CAMKK2	0.72338431
61	CAMK2A	0.72320179
62	STK11	0.72284365
63	CAMK1	0.65749705
64	STK38L	0.64818922
65	CAMK2B	0.64614714
66	CDK14	0.63981768
67	ROCK1	0.63720904
68	MKNK1	0.63399748
69	PRKCE	0.61342648
70	CSNK1A1	0.60152280
71	PRKCG	0.57709384
72	CSNK1D	0.56868164
73	ARAF	0.56708025
74	AURKA	0.56138090
75	AURKB	0.56035709
76	CDK19	0.54647331
77	MAP3K9	0.53776499
78	KSR1	0.53660742
79	TYRO3	0.52179033
80	DAPK2	0.52145739
81	TGFBR1	0.48697818
82	PRKD2	0.48087674
83	EIF2AK3	0.48006250
84	FLT3	0.47659349
85	CDK3	0.47453535
86	CAMK2G	0.46561425
87	MYLK	0.46497052
88	MAP3K5	0.45762122
89	RAF1	0.45722950
90	MAP3K7	0.45417427
91	PRKACA	0.43236410
92	TIE1	0.42977760
93	PRKAA1	0.42850703
94	SGK3	0.42616161
95	ZAK	0.42553034
96	CAMK2D	0.42382225
97	MAP3K12	0.41867565
98	BRSK2	0.39019286
99	PLK1	0.37791372
100	PRKD3	0.36466588

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.15913511
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.85661733
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.36647609
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.36616646
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26231818
6	Phototransduction_Homo sapiens_hsa04744	2.12892163
7	Basal transcription factors_Homo sapiens_hsa03022	2.12667154
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.07274133
9	Axon guidance_Homo sapiens_hsa04360	2.02462082
10	GABAergic synapse_Homo sapiens_hsa04727	2.01005966
11	beta-Alanine metabolism_Homo sapiens_hsa00410	1.85073165
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83820349
13	Circadian entrainment_Homo sapiens_hsa04713	1.82519775
14	Circadian rhythm_Homo sapiens_hsa04710	1.77324168
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74589803
16	RNA polymerase_Homo sapiens_hsa03020	1.69482548
17	Olfactory transduction_Homo sapiens_hsa04740	1.67729648
18	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.67099468
19	Butanoate metabolism_Homo sapiens_hsa00650	1.65745358
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65256122
21	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.46972647
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43647733
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42892784
24	Dopaminergic synapse_Homo sapiens_hsa04728	1.41429925
25	Morphine addiction_Homo sapiens_hsa05032	1.38197656
26	Propanoate metabolism_Homo sapiens_hsa00640	1.38039151
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.36365398
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28646839
29	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.25729258
30	Taste transduction_Homo sapiens_hsa04742	1.21141199
31	Cocaine addiction_Homo sapiens_hsa05030	1.20152543
32	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.14709010
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09924914
34	RNA degradation_Homo sapiens_hsa03018	1.08722573
35	Protein export_Homo sapiens_hsa03060	1.08699950
36	Cholinergic synapse_Homo sapiens_hsa04725	1.07808657
37	Amphetamine addiction_Homo sapiens_hsa05031	1.06273594
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.05792945
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.04793262
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04376872
41	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.99463532
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.98951927
43	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.97892737
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97892652
45	Serotonergic synapse_Homo sapiens_hsa04726	0.97667859
46	Insulin secretion_Homo sapiens_hsa04911	0.96989189
47	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.93251004
48	Gastric acid secretion_Homo sapiens_hsa04971	0.93135469
49	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.92906118
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91242020
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89381762
52	Long-term depression_Homo sapiens_hsa04730	0.89345192
53	Regulation of autophagy_Homo sapiens_hsa04140	0.89283495
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88405185
55	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.88231579
56	Parkinsons disease_Homo sapiens_hsa05012	0.85312296
57	Peroxisome_Homo sapiens_hsa04146	0.81173794
58	Salivary secretion_Homo sapiens_hsa04970	0.80756633
59	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.80573412
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80012817
61	Melanoma_Homo sapiens_hsa05218	0.77909882
62	Oocyte meiosis_Homo sapiens_hsa04114	0.77780862
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77130355
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.77087788
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.76534252
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.75972258
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.75958961
68	p53 signaling pathway_Homo sapiens_hsa04115	0.74533163
69	Gap junction_Homo sapiens_hsa04540	0.74061932
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.70998390
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.69464510
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69248476
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66876338
74	Homologous recombination_Homo sapiens_hsa03440	0.66765363
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66550833
76	Purine metabolism_Homo sapiens_hsa00230	0.62485077
77	Renin secretion_Homo sapiens_hsa04924	0.62410089
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.59935839
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.57451122
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.56419499
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.54390463
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.52711833
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.51782426
84	Melanogenesis_Homo sapiens_hsa04916	0.51683499
85	AMPK signaling pathway_Homo sapiens_hsa04152	0.50917465
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.49461496
87	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.49418878
88	ABC transporters_Homo sapiens_hsa02010	0.49209619
89	Lysine degradation_Homo sapiens_hsa00310	0.48876030
90	Tight junction_Homo sapiens_hsa04530	0.47976070
91	mRNA surveillance pathway_Homo sapiens_hsa03015	0.45062699
92	Ras signaling pathway_Homo sapiens_hsa04014	0.44855658
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44374033
94	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43443337
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42915339
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42752400
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.40808990
98	Alzheimers disease_Homo sapiens_hsa05010	0.40039402
99	Rap1 signaling pathway_Homo sapiens_hsa04015	0.39786881
100	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.39380015

RAB28P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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