RAB2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.64107236
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37253042
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.29757487
4synaptic vesicle exocytosis (GO:0016079)4.26489913
5regulation of synaptic vesicle exocytosis (GO:2000300)4.13322441
6nucleobase catabolic process (GO:0046113)4.04281824
7synaptic vesicle maturation (GO:0016188)4.04012102
8locomotory exploration behavior (GO:0035641)4.03969145
9neuron cell-cell adhesion (GO:0007158)3.93991809
10neuronal action potential propagation (GO:0019227)3.81633540
11glutamate secretion (GO:0014047)3.81125703
12vocalization behavior (GO:0071625)3.76495790
13regulation of synaptic vesicle transport (GO:1902803)3.61304829
14layer formation in cerebral cortex (GO:0021819)3.59281666
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51907212
16neuron recognition (GO:0008038)3.49898032
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49457166
18positive regulation of mitochondrial fission (GO:0090141)3.47271563
19protein localization to synapse (GO:0035418)3.43464107
20exploration behavior (GO:0035640)3.43161424
21regulation of glutamate receptor signaling pathway (GO:1900449)3.34279300
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.31241452
23axonal fasciculation (GO:0007413)3.20387481
24neurotransmitter secretion (GO:0007269)3.17054116
25dendritic spine morphogenesis (GO:0060997)3.16443858
26neurotransmitter-gated ion channel clustering (GO:0072578)3.16417557
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15815043
28glutamate receptor signaling pathway (GO:0007215)3.13821346
29activation of protein kinase A activity (GO:0034199)3.12880278
30regulation of neuronal synaptic plasticity (GO:0048168)3.05787661
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05779618
32calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.05413332
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04895252
34glycosphingolipid biosynthetic process (GO:0006688)3.03135300
35detection of calcium ion (GO:0005513)3.02170230
36regulation of synapse structural plasticity (GO:0051823)3.02052018
37presynaptic membrane assembly (GO:0097105)3.00885631
38cellular potassium ion homeostasis (GO:0030007)2.97466956
39gamma-aminobutyric acid signaling pathway (GO:0007214)2.95518953
40mating behavior (GO:0007617)2.94566453
41transmission of nerve impulse (GO:0019226)2.93511427
42neuron-neuron synaptic transmission (GO:0007270)2.93049748
43membrane budding (GO:0006900)2.92845221
44response to dietary excess (GO:0002021)2.91247502
45synaptic vesicle docking involved in exocytosis (GO:0016081)2.88229581
46protein localization to cilium (GO:0061512)2.87185420
47synaptic transmission, glutamatergic (GO:0035249)2.86892360
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86536448
49vesicle transport along microtubule (GO:0047496)2.86372181
50proline transport (GO:0015824)2.84853719
51dendrite morphogenesis (GO:0048813)2.84852654
52innervation (GO:0060384)2.80860047
53establishment of mitochondrion localization (GO:0051654)2.78430212
54regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.77727620
55regulation of vesicle fusion (GO:0031338)2.76750220
56regulation of dendritic spine morphogenesis (GO:0061001)2.75624749
57regulation of excitatory postsynaptic membrane potential (GO:0060079)2.74983278
58presynaptic membrane organization (GO:0097090)2.73642274
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73524952
60long-term synaptic potentiation (GO:0060291)2.73312186
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73291700
62L-serine transport (GO:0015825)2.71104169
63neurotransmitter transport (GO:0006836)2.71027250
64positive regulation of synapse assembly (GO:0051965)2.70830394
65organelle transport along microtubule (GO:0072384)2.69265436
66membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.69105528
67cerebellar Purkinje cell layer development (GO:0021680)2.67539742
68long-term memory (GO:0007616)2.66273551
69regulation of postsynaptic membrane potential (GO:0060078)2.65717636
70regulation of cell communication by electrical coupling (GO:0010649)2.63762190
71protein targeting to Golgi (GO:0000042)2.62008556
72postsynaptic membrane organization (GO:0001941)2.61794968
73positive regulation of membrane potential (GO:0045838)2.61791740
74auditory behavior (GO:0031223)2.61389512
75negative regulation of neurotransmitter transport (GO:0051589)2.61290939
76suckling behavior (GO:0001967)2.60756027
77regulation of synaptic plasticity (GO:0048167)2.60490055
78regulation of synapse assembly (GO:0051963)2.59543816
79gamma-aminobutyric acid transport (GO:0015812)2.58005916
80synapse organization (GO:0050808)2.56308236
81positive regulation of potassium ion transport (GO:0043268)2.55906419
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55396802
83short-term memory (GO:0007614)2.54618435
84chemosensory behavior (GO:0007635)2.54263482
85dendritic spine organization (GO:0097061)2.53003604
86synapse assembly (GO:0007416)2.51926390
87cell communication by electrical coupling (GO:0010644)2.51802307
88regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.51521432
89establishment of vesicle localization (GO:0051650)2.51482212
90Golgi transport vesicle coating (GO:0048200)2.50237282
91COPI coating of Golgi vesicle (GO:0048205)2.50237282
92lipid particle organization (GO:0034389)2.50082711
93regulation of neurotransmitter secretion (GO:0046928)2.49961163
94positive regulation of potassium ion transmembrane transport (GO:1901381)2.48204721
95neuronal ion channel clustering (GO:0045161)2.48071306
96regulation of neurotransmitter levels (GO:0001505)2.46964474
97protein maturation by protein folding (GO:0022417)2.46622405
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.46288754
99establishment of melanosome localization (GO:0032401)2.44331801
100axon extension (GO:0048675)2.44233988
101sodium ion export (GO:0071436)2.43791435
102cerebellar granule cell differentiation (GO:0021707)2.43693226
103fear response (GO:0042596)2.43540349
104calcium-mediated signaling using intracellular calcium source (GO:0035584)2.43536531
105synaptic vesicle endocytosis (GO:0048488)2.43412040
106endoplasmic reticulum organization (GO:0007029)2.42408839
107membrane repolarization during action potential (GO:0086011)2.41539656
108regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.41330543
109membrane repolarization (GO:0086009)2.41159550
110regulation of calcium ion-dependent exocytosis (GO:0017158)2.40599084
111regulation of dendritic spine development (GO:0060998)2.40456714
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.39895718
113neuron remodeling (GO:0016322)2.39147522
114G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.39100858
115neurofilament cytoskeleton organization (GO:0060052)2.38985937
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.38673590
117behavioral fear response (GO:0001662)2.38006575
118behavioral defense response (GO:0002209)2.38006575
119establishment of synaptic vesicle localization (GO:0097480)2.37646426
120synaptic vesicle transport (GO:0048489)2.37646426
121negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.37537920
122melanosome transport (GO:0032402)2.37398790
123regulation of feeding behavior (GO:0060259)2.36611825
124behavioral response to cocaine (GO:0048148)2.36489002
125positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33577325
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.33504953
127establishment of protein localization to Golgi (GO:0072600)2.33263181
128inner ear receptor cell development (GO:0060119)2.33216173
129regulation of amyloid precursor protein catabolic process (GO:1902991)2.31276855
130membrane depolarization (GO:0051899)2.31017144
131long term synaptic depression (GO:0060292)2.30608516
132peroxisome fission (GO:0016559)2.29764111
133heart contraction (GO:0060047)2.29700624
134heart process (GO:0003015)2.29700624
135response to auditory stimulus (GO:0010996)2.29571417
136establishment of pigment granule localization (GO:0051905)2.29161993
137energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.28757759
138ATP hydrolysis coupled proton transport (GO:0015991)2.28757759
139regulation of cAMP-dependent protein kinase activity (GO:2000479)2.28207733
140cerebral cortex radially oriented cell migration (GO:0021799)2.26031637
141negative regulation of microtubule polymerization (GO:0031115)2.25253386
142regulation of mitochondrial fission (GO:0090140)2.23159323
143retinal ganglion cell axon guidance (GO:0031290)2.21898958
144pigment granule transport (GO:0051904)2.21854582
145transferrin transport (GO:0033572)2.21334423
146regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.20350664
147neuron projection extension (GO:1990138)2.20099141
148ribonucleoprotein complex disassembly (GO:0032988)2.19611082
149homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.19526076
150acidic amino acid transport (GO:0015800)2.19309697
151substantia nigra development (GO:0021762)2.18449149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03174796
2GBX2_23144817_ChIP-Seq_PC3_Human3.08955163
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89514581
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88257849
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75953370
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51464069
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51464069
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50485005
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48585544
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41249807
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40345029
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36570923
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31975347
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.31753325
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.19566285
16REST_21632747_ChIP-Seq_MESCs_Mouse2.09904598
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.02135543
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01773974
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.95940334
20ZNF274_21170338_ChIP-Seq_K562_Hela1.88883537
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.88830781
22DROSHA_22980978_ChIP-Seq_HELA_Human1.84439571
23TAF15_26573619_Chip-Seq_HEK293_Human1.84411528
24AR_21572438_ChIP-Seq_LNCaP_Human1.81452053
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80244784
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76509763
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.68735088
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64830070
29NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63307578
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61274776
31SMAD4_21799915_ChIP-Seq_A2780_Human1.56307851
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55231355
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55178554
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54198695
35* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47837131
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46229785
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.45627796
38RNF2_27304074_Chip-Seq_NSC_Mouse1.44921455
39P300_19829295_ChIP-Seq_ESCs_Human1.42622825
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41187246
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40515797
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38449517
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38299646
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35402512
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35012386
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34540451
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.33181965
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.30827769
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30099367
50* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29953781
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29437377
52IGF1R_20145208_ChIP-Seq_DFB_Human1.27795953
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27199850
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27104932
55* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25213648
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24896082
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24481263
58AR_25329375_ChIP-Seq_VCAP_Human1.24232356
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.24167738
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24060638
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.23265279
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21457185
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21272716
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20926594
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.19372710
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.18861919
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.18691178
68BCAT_22108803_ChIP-Seq_LS180_Human1.18113339
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17912834
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17875785
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.17302211
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16875792
73TP53_18474530_ChIP-ChIP_U2OS_Human1.16874558
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.16654993
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15401687
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14929905
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14929905
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14872563
79CBP_20019798_ChIP-Seq_JUKART_Human1.14513000
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14513000
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14054886
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13771891
83* STAT3_23295773_ChIP-Seq_U87_Human1.13621260
84* P53_22387025_ChIP-Seq_ESCs_Mouse1.13058047
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12678132
86FUS_26573619_Chip-Seq_HEK293_Human1.12648716
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.12551352
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12510700
89JUN_21703547_ChIP-Seq_K562_Human1.12384923
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.10527867
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09398128
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08339411
93* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07790115
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06853454
95VDR_22108803_ChIP-Seq_LS180_Human1.06766266
96TP53_16413492_ChIP-PET_HCT116_Human1.06468358
97AHR_22903824_ChIP-Seq_MCF-7_Human1.05698307
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05309836
99AR_19668381_ChIP-Seq_PC3_Human1.03924489
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.03863182
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03345197
102CJUN_26792858_Chip-Seq_BT549_Human1.02434758
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01649258
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01010576
105EWS_26573619_Chip-Seq_HEK293_Human1.00819829
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00661666
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00445681
108* RUNX2_22187159_ChIP-Seq_PCA_Human0.99852127
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.99493274
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.99355610
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97751643
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.97457815
113SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97300081
114TCF4_23295773_ChIP-Seq_U87_Human0.96070435
115ER_23166858_ChIP-Seq_MCF-7_Human0.95488708
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.91144529
117RXR_22108803_ChIP-Seq_LS180_Human0.90974272
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.90420019
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90214416
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89203122
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.87896700
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86911732
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.86702332
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86681121
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.86202496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.83976798
2MP0003880_abnormal_central_pattern4.50183034
3MP0004270_analgesia3.69276123
4MP0003635_abnormal_synaptic_transmissio3.40075660
5MP0009780_abnormal_chondrocyte_physiolo2.81304698
6MP0002063_abnormal_learning/memory/cond2.66945207
7MP0009745_abnormal_behavioral_response2.64763510
8MP0002064_seizures2.52107305
9MP0002909_abnormal_adrenal_gland2.43919395
10MP0002734_abnormal_mechanical_nocicepti2.36120027
11MP0001968_abnormal_touch/_nociception2.29243070
12MP0002572_abnormal_emotion/affect_behav2.23915618
13MP0002272_abnormal_nervous_system2.19545118
14MP0003329_amyloid_beta_deposits2.14410474
15MP0002837_dystrophic_cardiac_calcinosis2.06968657
16MP0009046_muscle_twitch2.06929894
17MP0006276_abnormal_autonomic_nervous2.02223525
18MP0000013_abnormal_adipose_tissue1.97892362
19MP0001440_abnormal_grooming_behavior1.92418141
20MP0001486_abnormal_startle_reflex1.91863315
21MP0001501_abnormal_sleep_pattern1.86546432
22MP0002733_abnormal_thermal_nociception1.84474375
23MP0004145_abnormal_muscle_electrophysio1.71582392
24MP0000778_abnormal_nervous_system1.69404055
25MP0002736_abnormal_nociception_after1.69352536
26MP0002735_abnormal_chemical_nociception1.69224620
27MP0002067_abnormal_sensory_capabilities1.68335442
28MP0001970_abnormal_pain_threshold1.68083689
29MP0005423_abnormal_somatic_nervous1.67098614
30MP0008438_abnormal_cutaneous_collagen1.67031002
31MP0010386_abnormal_urinary_bladder1.62077720
32MP0002184_abnormal_innervation1.60319917
33MP0004924_abnormal_behavior1.54287764
34MP0005386_behavior/neurological_phenoty1.54287764
35MP0003122_maternal_imprinting1.53744493
36MP0010234_abnormal_vibrissa_follicle1.51494860
37MP0000751_myopathy1.49683129
38MP0004858_abnormal_nervous_system1.46643606
39MP0002102_abnormal_ear_morphology1.46430428
40MP0003283_abnormal_digestive_organ1.46283729
41MP0002638_abnormal_pupillary_reflex1.45614455
42MP0004043_abnormal_pH_regulation1.43248033
43MP0002557_abnormal_social/conspecific_i1.42033576
44MP0008569_lethality_at_weaning1.37991456
45MP0000955_abnormal_spinal_cord1.36744045
46MP0005248_abnormal_Harderian_gland1.34807753
47MP0002822_catalepsy1.34662663
48MP0004885_abnormal_endolymph1.33281887
49MP0005275_abnormal_skin_tensile1.30955090
50MP0004811_abnormal_neuron_physiology1.29749704
51MP0001905_abnormal_dopamine_level1.27448739
52MP0005646_abnormal_pituitary_gland1.27047482
53MP0001529_abnormal_vocalization1.26032810
54MP0003221_abnormal_cardiomyocyte_apopto1.26020918
55MP0002066_abnormal_motor_capabilities/c1.23027840
56MP0003633_abnormal_nervous_system1.20405886
57MP0002882_abnormal_neuron_morphology1.19658038
58MP0001984_abnormal_olfaction1.17102025
59MP0001299_abnormal_eye_distance/1.13030627
60MP0000920_abnormal_myelination1.10406188
61MP0003879_abnormal_hair_cell1.09709764
62MP0001502_abnormal_circadian_rhythm1.07588945
63MP0005645_abnormal_hypothalamus_physiol1.03519068
64MP0004215_abnormal_myocardial_fiber1.02870736
65MP0004085_abnormal_heartbeat0.98652769
66MP0005535_abnormal_body_temperature0.97907007
67MP0003634_abnormal_glial_cell0.96325397
68MP0002234_abnormal_pharynx_morphology0.93083139
69MP0003631_nervous_system_phenotype0.92620037
70MP0005394_taste/olfaction_phenotype0.92331873
71MP0005499_abnormal_olfactory_system0.92331873
72MP0001944_abnormal_pancreas_morphology0.91439538
73MP0004484_altered_response_of0.91131980
74MP0005187_abnormal_penis_morphology0.90867842
75MP0005503_abnormal_tendon_morphology0.90430707
76MP0004742_abnormal_vestibular_system0.89559910
77MP0002332_abnormal_exercise_endurance0.89147986
78MP0004142_abnormal_muscle_tone0.88500195
79MP0005253_abnormal_eye_physiology0.87618878
80MP0000604_amyloidosis0.87618108
81MP0002229_neurodegeneration0.87568839
82MP0005623_abnormal_meninges_morphology0.85981128
83MP0000631_abnormal_neuroendocrine_gland0.85951869
84MP0001664_abnormal_digestion0.85788544
85MP0000747_muscle_weakness0.85156879
86MP0000749_muscle_degeneration0.85139343
87MP0002152_abnormal_brain_morphology0.85010427
88MP0002069_abnormal_eating/drinking_beha0.84814513
89MP0002295_abnormal_pulmonary_circulatio0.83864883
90MP0008789_abnormal_olfactory_epithelium0.83763886
91MP0004272_abnormal_basement_membrane0.82974287
92MP0002693_abnormal_pancreas_physiology0.82136831
93MP0001542_abnormal_bone_strength0.81616160
94MP0006072_abnormal_retinal_apoptosis0.81486639
95MP0001188_hyperpigmentation0.80799819
96MP0005379_endocrine/exocrine_gland_phen0.80573594
97MP0001765_abnormal_ion_homeostasis0.79202070
98MP0004130_abnormal_muscle_cell0.78814419
99MP0004036_abnormal_muscle_relaxation0.78298421
100MP0000569_abnormal_digit_pigmentation0.77523869
101MP0000750_abnormal_muscle_regeneration0.77327998
102MP0002972_abnormal_cardiac_muscle0.77044299
103MP0008961_abnormal_basal_metabolism0.76584982
104MP0002751_abnormal_autonomic_nervous0.76259639
105MP0002896_abnormal_bone_mineralization0.75853743
106MP0000049_abnormal_middle_ear0.74371222
107MP0002876_abnormal_thyroid_physiology0.74039517
108MP0000003_abnormal_adipose_tissue0.73934285
109MP0003011_delayed_dark_adaptation0.72300326
110MP0000462_abnormal_digestive_system0.71845409
111MP0001485_abnormal_pinna_reflex0.70981334
112MP0005620_abnormal_muscle_contractility0.70895848
113MP0003890_abnormal_embryonic-extraembry0.70560316
114MP0002752_abnormal_somatic_nervous0.69502866
115MP0005551_abnormal_eye_electrophysiolog0.69324206
116MP0003195_calcinosis0.69279600
117MP0000639_abnormal_adrenal_gland0.68286704
118MP0002090_abnormal_vision0.68190800
119MP0002877_abnormal_melanocyte_morpholog0.68014032
120MP0001177_atelectasis0.66950458
121MP0000026_abnormal_inner_ear0.66331070
122MP0003137_abnormal_impulse_conducting0.65982450
123MP0002078_abnormal_glucose_homeostasis0.65464359
124MP0001879_abnormal_lymphatic_vessel0.65311698
125MP0003787_abnormal_imprinting0.65080566
126MP0001963_abnormal_hearing_physiology0.65063009
127MP0005084_abnormal_gallbladder_morpholo0.64256753
128MP0008874_decreased_physiological_sensi0.63853936
129MP0003690_abnormal_glial_cell0.63428656

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.39753182
2Visual hallucinations (HP:0002367)4.47577827
3Myokymia (HP:0002411)4.30040901
4Atonic seizures (HP:0010819)4.19916040
5Focal seizures (HP:0007359)3.99105000
6Absence seizures (HP:0002121)3.56939207
7Neurofibrillary tangles (HP:0002185)3.51895642
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.51586790
9Cerebral inclusion bodies (HP:0100314)3.47395325
10Epileptic encephalopathy (HP:0200134)3.29388248
11Pheochromocytoma (HP:0002666)3.23813253
12Split foot (HP:0001839)3.23699323
13Supranuclear gaze palsy (HP:0000605)3.22785987
14Action tremor (HP:0002345)3.19767072
15Termporal pattern (HP:0011008)3.16164795
16Insidious onset (HP:0003587)3.16164795
17Dialeptic seizures (HP:0011146)3.06128949
18Gait imbalance (HP:0002141)3.03808550
19Generalized tonic-clonic seizures (HP:0002069)2.98756134
20Hyperventilation (HP:0002883)2.97919292
21Progressive cerebellar ataxia (HP:0002073)2.97090870
22Neuroendocrine neoplasm (HP:0100634)2.93276326
23Agitation (HP:0000713)2.92723083
24Anxiety (HP:0000739)2.89290124
25Shoulder girdle muscle weakness (HP:0003547)2.75777215
26Papilledema (HP:0001085)2.70138963
27Depression (HP:0000716)2.67136345
28Abnormality of the musculature of the pelvis (HP:0001469)2.66914907
29Abnormality of the hip-girdle musculature (HP:0001445)2.66914907
30Congenital primary aphakia (HP:0007707)2.65708765
31Medial flaring of the eyebrow (HP:0010747)2.65696282
32Amyotrophic lateral sclerosis (HP:0007354)2.64754488
33Broad-based gait (HP:0002136)2.61699557
34Failure to thrive in infancy (HP:0001531)2.54084137
35Dysmetria (HP:0001310)2.51852573
36Amblyopia (HP:0000646)2.50714362
37Truncal ataxia (HP:0002078)2.49114917
38Poor suck (HP:0002033)2.46384375
39Febrile seizures (HP:0002373)2.46333081
40Excessive salivation (HP:0003781)2.45738497
41Drooling (HP:0002307)2.45738497
42Rimmed vacuoles (HP:0003805)2.45126364
43Scanning speech (HP:0002168)2.40832869
44Nephrogenic diabetes insipidus (HP:0009806)2.40293165
45Ankle clonus (HP:0011448)2.37783305
46Exercise-induced muscle cramps (HP:0003710)2.36315386
47Megalencephaly (HP:0001355)2.35601074
48Retinal dysplasia (HP:0007973)2.29542837
49Epileptiform EEG discharges (HP:0011182)2.29533806
50Dysdiadochokinesis (HP:0002075)2.29394853
51Progressive inability to walk (HP:0002505)2.28523136
52Poor eye contact (HP:0000817)2.28169254
53Abnormality of the corticospinal tract (HP:0002492)2.27475426
54Intention tremor (HP:0002080)2.22727242
55Abnormality of calcium-phosphate metabolism (HP:0100530)2.21159943
56EEG with generalized epileptiform discharges (HP:0011198)2.20339507
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.19738910
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.19036517
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19036517
60Limb-girdle muscle weakness (HP:0003325)2.18908427
61Abnormal eating behavior (HP:0100738)2.14590822
62Abnormal social behavior (HP:0012433)2.14496964
63Impaired social interactions (HP:0000735)2.14496964
64Delayed gross motor development (HP:0002194)2.13719604
65Limb dystonia (HP:0002451)2.12785810
66Impaired vibration sensation in the lower limbs (HP:0002166)2.12097717
67Pelvic girdle muscle weakness (HP:0003749)2.09943743
68Hypsarrhythmia (HP:0002521)2.09119973
69Postural tremor (HP:0002174)2.08907887
70Abnormality of the lower motor neuron (HP:0002366)2.06695022
71Mutism (HP:0002300)2.05069842
72Ventricular fibrillation (HP:0001663)2.04649308
73Papillary thyroid carcinoma (HP:0002895)2.04587206
74Muscular hypotonia of the trunk (HP:0008936)2.03549363
75Genital tract atresia (HP:0001827)2.02611315
76Cortical dysplasia (HP:0002539)2.02328233
77Limb-girdle muscle atrophy (HP:0003797)2.02282352
78Hyperthyroidism (HP:0000836)2.01642500
79Buphthalmos (HP:0000557)2.01160009
80Spastic gait (HP:0002064)2.01093403
81Type II lissencephaly (HP:0007260)2.01087184
82Neoplasm of the peripheral nervous system (HP:0100007)2.00987755
83Genetic anticipation (HP:0003743)2.00613269
84Vaginal atresia (HP:0000148)2.00139792
85Ulnar claw (HP:0001178)1.99200247
86Hypoventilation (HP:0002791)1.98895911
87Rapidly progressive (HP:0003678)1.98447887
88Hypercortisolism (HP:0001578)1.97610739
89Urinary urgency (HP:0000012)1.97375104
90Specific learning disability (HP:0001328)1.97307082
91Spastic tetraplegia (HP:0002510)1.96632413
92Exotropia (HP:0000577)1.94857796
93Increased circulating renin level (HP:0000848)1.93830193
94Absent speech (HP:0001344)1.90695609
95Gaze-evoked nystagmus (HP:0000640)1.88927723
96Inability to walk (HP:0002540)1.88229081
97Psychosis (HP:0000709)1.87899507
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86422176
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86422176
100Torticollis (HP:0000473)1.86037565
101Akinesia (HP:0002304)1.85730337
102Postural instability (HP:0002172)1.83901174
103Blue irides (HP:0000635)1.83863048
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83602858
105Ankyloglossia (HP:0010296)1.83334576
106Clonus (HP:0002169)1.83097351
107Cerebral hemorrhage (HP:0001342)1.83089955
108Generalized myoclonic seizures (HP:0002123)1.82839641
109Prolonged QT interval (HP:0001657)1.82139667
110Ketoacidosis (HP:0001993)1.81641436
111Hyperinsulinemic hypoglycemia (HP:0000825)1.77026351
112Delusions (HP:0000746)1.76444618
113Hypoglycemic coma (HP:0001325)1.76141365
114Hammertoe (HP:0001765)1.75297855
115Syncope (HP:0001279)1.74516713
116Congenital glaucoma (HP:0001087)1.73885360
117Focal dystonia (HP:0004373)1.73460168
118Urinary bladder sphincter dysfunction (HP:0002839)1.73391290
119Bradykinesia (HP:0002067)1.70989212
120Hypothermia (HP:0002045)1.70694930
121Sensorimotor neuropathy (HP:0007141)1.70651179
122Abnormality of the calf musculature (HP:0001430)1.70152627
123Hyperparathyroidism (HP:0000843)1.69212911
124Prominent supraorbital ridges (HP:0000336)1.68798327
125Decreased circulating renin level (HP:0003351)1.68784768
126Lower limb muscle weakness (HP:0007340)1.67729153
127Hemiparesis (HP:0001269)1.67429721
128Pachygyria (HP:0001302)1.67073535
129Peripheral hypomyelination (HP:0007182)1.66863789
130Gait ataxia (HP:0002066)1.66508443
131Sudden death (HP:0001699)1.65952769
132Menstrual irregularities (HP:0000858)1.65645200
133Thickened helices (HP:0000391)1.65069656
134Craniofacial dystonia (HP:0012179)1.63931073
135Polyphagia (HP:0002591)1.63819696
136Stereotypic behavior (HP:0000733)1.63736533
137Abnormality of salivation (HP:0100755)1.63117973
138Premature rupture of membranes (HP:0001788)1.62724771
139Bronchomalacia (HP:0002780)1.61865077
140Methylmalonic acidemia (HP:0002912)1.61580303
141Metaphyseal dysplasia (HP:0100255)1.61505604
142Abnormal EKG (HP:0003115)1.61037554
143Morphological abnormality of the pyramidal tract (HP:0002062)1.59162526
144Esotropia (HP:0000565)1.58920357
145Hand muscle atrophy (HP:0009130)1.57951791
146Heterochromia iridis (HP:0001100)1.57879327
147Autoamputation (HP:0001218)1.57763919
148Ankle contracture (HP:0006466)1.57294543
149Follicular hyperkeratosis (HP:0007502)1.56867638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.92214012
2EPHA43.33790470
3TRIM282.96229364
4MAP3K92.92921595
5MAP3K42.63116925
6MARK12.60525557
7TESK12.49412248
8NTRK12.44689768
9ERBB32.28830896
10EPHA32.25633274
11MAP3K122.24989700
12MINK12.22306420
13KSR22.15327313
14MAP2K72.13429492
15MAP3K22.07705917
16MAP2K41.95547708
17MAP4K21.93084843
18RIPK41.84510121
19PAK61.82904700
20PNCK1.67977109
21PRKD31.62741487
22STK391.62052188
23DAPK21.61425466
24OXSR11.59755731
25CASK1.54447756
26CAMKK21.54364545
27CDK191.53418231
28CSNK1G11.52075380
29WNK41.50049967
30TNIK1.48994535
31KSR11.48878052
32PLK21.43252699
33CDK51.40054832
34PAK31.37798515
35UHMK11.37507618
36GRK51.36074665
37FRK1.35760829
38ARAF1.33686956
39RET1.28255492
40NTRK21.27825863
41CAMKK11.27264891
42CAMK2B1.17074855
43FER1.17058851
44PHKG11.16665331
45PHKG21.16665331
46INSRR1.15877607
47MYLK1.15625073
48CAMK2A1.15325081
49DYRK21.11981597
50STK38L1.11024578
51NME11.10884591
52SCYL21.09284212
53MAPK131.08644957
54CSNK1G21.02224828
55CAMK2D0.95957730
56SIK30.95848075
57PTK2B0.94857944
58BCR0.93843063
59PRKCG0.91586638
60MAP3K10.89847388
61TYRO30.88708164
62FES0.88142825
63WNK10.86477686
64CDK140.85918330
65DMPK0.83565576
66MAP3K50.82434310
67PRKCE0.81658100
68FGFR20.79795159
69LATS20.79394195
70DAPK10.77809956
71PRKCH0.76021479
72DYRK30.75703491
73DYRK1B0.75137835
74PDGFRA0.75107873
75BCKDK0.74981327
76LMTK20.74079630
77WNK30.73230345
78RPS6KA40.72595511
79CAMK2G0.72190617
80STK110.72116876
81SGK2230.69517769
82SGK4940.69517769
83LIMK10.68367516
84CDK180.67667926
85OBSCN0.67265273
86PDPK10.67150434
87FGR0.66753287
88CDK150.66142953
89EPHB10.65462306
90LATS10.65437121
91DDR20.64740653
92SIK20.64325196
93PTK20.64091889
94MAPKAPK50.63635272
95BMPR20.62415732
96HIPK20.61337897
97RAF10.59563763
98STK380.59312421
99PIM20.58009785
100PDK20.57729526
101DYRK1A0.57361419
102TAOK10.56988153
103MAP2K10.56854292
104CSNK1G30.55696197
105ROCK20.54492666
106CDK11A0.53581110
107CAMK10.53393948
108MAP3K60.52834686
109NEK10.52121920
110CAMK1G0.51334006
111SRPK10.50300250
112SGK10.50073608
113TIE10.49989273
114PDK10.48783333
115PINK10.48248069
116PIK3CA0.47966352
117CSNK1A1L0.47413847
118ADRBK10.47050350
119MET0.46794725
120EPHB20.46073667
121GRK70.44031398
122PRKG10.43462223
123MARK20.43424036
124PKN10.43100339
125FYN0.43092570
126ABL20.42965205
127MAP3K130.42869706
128PRKACA0.42636176
129ROCK10.40678881
130CAMK40.39456100
131PRKCZ0.39412250
132PRKD10.35968512
133CSNK1A10.35754890
134PRKACB0.35111945
135MST40.30859120
136PRKACG0.30036954
137ERBB40.29836194
138PAK40.29537434

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.68884429
2Synaptic vesicle cycle_Homo sapiens_hsa047212.48218899
3Long-term potentiation_Homo sapiens_hsa047202.39474497
4Amphetamine addiction_Homo sapiens_hsa050312.22149728
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20574952
6GABAergic synapse_Homo sapiens_hsa047272.20030585
7Circadian entrainment_Homo sapiens_hsa047132.16598839
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13710893
9Insulin secretion_Homo sapiens_hsa049112.06453720
10Dopaminergic synapse_Homo sapiens_hsa047282.01868876
11Glutamatergic synapse_Homo sapiens_hsa047242.01351232
12Morphine addiction_Homo sapiens_hsa050321.89249390
13Olfactory transduction_Homo sapiens_hsa047401.78774045
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75960197
15Salivary secretion_Homo sapiens_hsa049701.73638272
16Renin secretion_Homo sapiens_hsa049241.68815062
17Cocaine addiction_Homo sapiens_hsa050301.68762084
18Gastric acid secretion_Homo sapiens_hsa049711.67852378
19Taste transduction_Homo sapiens_hsa047421.64713065
20Serotonergic synapse_Homo sapiens_hsa047261.62690617
21Cholinergic synapse_Homo sapiens_hsa047251.62393746
22Long-term depression_Homo sapiens_hsa047301.61526916
23Collecting duct acid secretion_Homo sapiens_hsa049661.59249701
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57566519
25Vibrio cholerae infection_Homo sapiens_hsa051101.57549759
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44813522
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42809818
28Oxytocin signaling pathway_Homo sapiens_hsa049211.37544276
29GnRH signaling pathway_Homo sapiens_hsa049121.26973640
30Pancreatic secretion_Homo sapiens_hsa049721.25618164
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25462416
32Cardiac muscle contraction_Homo sapiens_hsa042601.22998193
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22933388
34Gap junction_Homo sapiens_hsa045401.21972539
35Fatty acid elongation_Homo sapiens_hsa000621.21138031
36Calcium signaling pathway_Homo sapiens_hsa040201.20768571
37Oxidative phosphorylation_Homo sapiens_hsa001901.19897848
38Steroid biosynthesis_Homo sapiens_hsa001001.18660651
39Alzheimers disease_Homo sapiens_hsa050101.18046213
40Propanoate metabolism_Homo sapiens_hsa006401.18019402
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.14719595
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13422248
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13209173
44Type II diabetes mellitus_Homo sapiens_hsa049301.12641621
45Estrogen signaling pathway_Homo sapiens_hsa049151.11510176
46Axon guidance_Homo sapiens_hsa043601.09737001
47cAMP signaling pathway_Homo sapiens_hsa040241.08522137
48Sulfur metabolism_Homo sapiens_hsa009201.06729718
49Folate biosynthesis_Homo sapiens_hsa007901.06056010
50Nitrogen metabolism_Homo sapiens_hsa009101.04846223
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02978153
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02312371
53Melanogenesis_Homo sapiens_hsa049161.01422221
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.99519121
55Thyroid hormone synthesis_Homo sapiens_hsa049180.98817001
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97315793
57Glioma_Homo sapiens_hsa052140.96611311
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94982451
59Regulation of autophagy_Homo sapiens_hsa041400.93111021
60Parkinsons disease_Homo sapiens_hsa050120.92390211
61beta-Alanine metabolism_Homo sapiens_hsa004100.90248939
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90138958
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89576620
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88133287
65Dorso-ventral axis formation_Homo sapiens_hsa043200.88006519
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83807485
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83334740
68Protein export_Homo sapiens_hsa030600.83113647
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81682372
70ErbB signaling pathway_Homo sapiens_hsa040120.81232903
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81065324
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78267110
73Dilated cardiomyopathy_Homo sapiens_hsa054140.76866870
74Arginine and proline metabolism_Homo sapiens_hsa003300.76835165
75Peroxisome_Homo sapiens_hsa041460.75235543
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74267351
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70110890
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69747326
79Glucagon signaling pathway_Homo sapiens_hsa049220.69013242
80Vitamin B6 metabolism_Homo sapiens_hsa007500.68462760
81VEGF signaling pathway_Homo sapiens_hsa043700.68230025
82Pyruvate metabolism_Homo sapiens_hsa006200.67037949
83Renal cell carcinoma_Homo sapiens_hsa052110.66906395
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65214953
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.64387057
86Fatty acid metabolism_Homo sapiens_hsa012120.63888745
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62829875
88Phenylalanine metabolism_Homo sapiens_hsa003600.59103786
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58783664
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58744550
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58468455
92Choline metabolism in cancer_Homo sapiens_hsa052310.58322901
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58131441
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.56868911
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56751373
96Ras signaling pathway_Homo sapiens_hsa040140.56661014
97Prion diseases_Homo sapiens_hsa050200.55144735
98Butanoate metabolism_Homo sapiens_hsa006500.54175943
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.53940165
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51412776
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51260969
102Arginine biosynthesis_Homo sapiens_hsa002200.51204601
103PPAR signaling pathway_Homo sapiens_hsa033200.50928711
104Mineral absorption_Homo sapiens_hsa049780.50385139
105Tryptophan metabolism_Homo sapiens_hsa003800.50079506
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.49727387
107Bile secretion_Homo sapiens_hsa049760.49495481
108MAPK signaling pathway_Homo sapiens_hsa040100.49443540
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49337579
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47084554
111Oocyte meiosis_Homo sapiens_hsa041140.46981905
112Insulin signaling pathway_Homo sapiens_hsa049100.46465724
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45016179
114Endocytosis_Homo sapiens_hsa041440.44893090
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44408144
116Rap1 signaling pathway_Homo sapiens_hsa040150.44404795
117Huntingtons disease_Homo sapiens_hsa050160.43822434
118Circadian rhythm_Homo sapiens_hsa047100.43217156
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43190468
120Histidine metabolism_Homo sapiens_hsa003400.43121314
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42261463
122Phagosome_Homo sapiens_hsa041450.42080036
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41948475
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41082730
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41037423
126Ovarian steroidogenesis_Homo sapiens_hsa049130.40922684
127Wnt signaling pathway_Homo sapiens_hsa043100.40851498
128Alcoholism_Homo sapiens_hsa050340.40720367
129* AMPK signaling pathway_Homo sapiens_hsa041520.40430347
130Tight junction_Homo sapiens_hsa045300.40184046
131Phototransduction_Homo sapiens_hsa047440.40152889
132Caffeine metabolism_Homo sapiens_hsa002320.40022626
133mTOR signaling pathway_Homo sapiens_hsa041500.38580745
134Type I diabetes mellitus_Homo sapiens_hsa049400.37248908
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37208239
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36656251
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35933318
138Endometrial cancer_Homo sapiens_hsa052130.33897018

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