RAB31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.42409640
2axon ensheathment in central nervous system (GO:0032291)8.42409640
3myelination (GO:0042552)5.95359699
4ensheathment of neurons (GO:0007272)5.88246922
5axon ensheathment (GO:0008366)5.88246922
6myelin maintenance (GO:0043217)5.12408452
7astrocyte development (GO:0014002)4.83352660
8L-amino acid import (GO:0043092)4.82790489
9fatty acid elongation (GO:0030497)4.77063575
10leukocyte migration involved in inflammatory response (GO:0002523)4.72110116
11oligodendrocyte differentiation (GO:0048709)4.54059455
12response to peptidoglycan (GO:0032494)4.52903886
13negative regulation of protein localization to cell surface (GO:2000009)4.52455317
14myelination in peripheral nervous system (GO:0022011)4.40753585
15peripheral nervous system axon ensheathment (GO:0032292)4.40753585
16positive regulation of mast cell activation (GO:0033005)4.33448725
17detection of molecule of bacterial origin (GO:0032490)4.33333678
18long-chain fatty acid biosynthetic process (GO:0042759)4.26541376
19gonadal mesoderm development (GO:0007506)4.20619344
20adhesion of symbiont to host cell (GO:0044650)4.14567784
21virion attachment to host cell (GO:0019062)4.14567784
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.11309581
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.08319282
24negative regulation of neurotransmitter secretion (GO:0046929)4.03672805
25amino acid import (GO:0043090)4.02983018
26cellular extravasation (GO:0045123)3.95856587
27positive regulation of mast cell degranulation (GO:0043306)3.94699838
28positive regulation of mast cell activation involved in immune response (GO:0033008)3.94699838
29neutrophil activation involved in immune response (GO:0002283)3.84038253
30neutrophil activation (GO:0042119)3.79079304
31response to lipoprotein particle (GO:0055094)3.78993306
32macrophage activation involved in immune response (GO:0002281)3.73481140
33regulation of mast cell degranulation (GO:0043304)3.71923150
34granulocyte activation (GO:0036230)3.71665155
35dermatan sulfate biosynthetic process (GO:0030208)3.70912548
36negative regulation of interleukin-12 production (GO:0032695)3.70491885
37adenosine receptor signaling pathway (GO:0001973)3.68211395
38detection of other organism (GO:0098543)3.60341089
39dermatan sulfate metabolic process (GO:0030205)3.59729805
40regulation of collateral sprouting (GO:0048670)3.59116219
41cellular response to thyroid hormone stimulus (GO:0097067)3.58157204
42cholesterol biosynthetic process (GO:0006695)3.54989096
43cerebral cortex radially oriented cell migration (GO:0021799)3.54313798
44detection of external biotic stimulus (GO:0098581)3.54181169
45positive regulation of leukocyte degranulation (GO:0043302)3.54098281
46regulation of mast cell activation involved in immune response (GO:0033006)3.53006622
47glycosylceramide metabolic process (GO:0006677)3.45206616
48regulation of mast cell activation (GO:0033003)3.44424698
49negative regulation of neurotransmitter transport (GO:0051589)3.41787339
50positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.41018759
51regulation of leukocyte degranulation (GO:0043300)3.40080418
52regulation of platelet activation (GO:0010543)3.36517393
53adhesion of symbiont to host (GO:0044406)3.35625017
54regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33802247
55positive regulation of oligodendrocyte differentiation (GO:0048714)3.27057149
56presynaptic membrane assembly (GO:0097105)3.25579987
57import into cell (GO:0098657)3.25505492
58macrophage activation (GO:0042116)3.24467506
59photoreceptor cell differentiation (GO:0046530)3.22618119
60eye photoreceptor cell differentiation (GO:0001754)3.22618119
61barbed-end actin filament capping (GO:0051016)3.21551922
62regulation of T-helper 2 cell differentiation (GO:0045628)3.17459924
63regulation of platelet aggregation (GO:0090330)3.17214897
64amyloid precursor protein catabolic process (GO:0042987)3.16910170
65positive regulation of receptor recycling (GO:0001921)3.16255421
66positive regulation of actin filament depolymerization (GO:0030836)3.14844404
67presynaptic membrane organization (GO:0097090)3.14625927
68asymmetric protein localization (GO:0008105)3.13147412
69substantia nigra development (GO:0021762)3.12466296
70glial cell development (GO:0021782)3.09871083
71glycosphingolipid catabolic process (GO:0046479)3.09430140
72sterol biosynthetic process (GO:0016126)3.09023166
73detection of bacterium (GO:0016045)3.07699801
74lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06341085
75detection of biotic stimulus (GO:0009595)3.05471340
76regulation of integrin-mediated signaling pathway (GO:2001044)3.04372410
77negative regulation of interleukin-17 production (GO:0032700)3.03785245
78immunoglobulin mediated immune response (GO:0016064)3.00415031
79amyloid precursor protein metabolic process (GO:0042982)3.00076548
80myeloid cell activation involved in immune response (GO:0002275)2.98661750
81positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.97452757
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96057344
83response to host immune response (GO:0052572)2.96057344
84membrane invagination (GO:0010324)2.96001734
85positive regulation of gamma-delta T cell activation (GO:0046645)2.95714949
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93851526
87lens fiber cell development (GO:0070307)2.91837510
88membrane protein ectodomain proteolysis (GO:0006509)2.91328369
89isoprenoid biosynthetic process (GO:0008299)2.91028660
90apical protein localization (GO:0045176)2.90782081
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88448645
92protein localization to endosome (GO:0036010)2.87356434
93positive regulation of osteoblast proliferation (GO:0033690)2.85909460
94mannosylation (GO:0097502)2.85574450
95chondroitin sulfate catabolic process (GO:0030207)2.83906902
96negative regulation of axonogenesis (GO:0050771)2.82953448
97positive regulation of type 2 immune response (GO:0002830)2.81963422
98negative regulation of cell killing (GO:0031342)2.81304967
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81304967
100neuroblast proliferation (GO:0007405)2.80129292
101regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79934682
102creatine metabolic process (GO:0006600)2.78895565
103positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.76265195
104regulation of amyloid precursor protein catabolic process (GO:1902991)2.74076100
105positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73959210
106phagocytosis, engulfment (GO:0006911)2.72558780
107limb bud formation (GO:0060174)2.72116215
108regulation of regulated secretory pathway (GO:1903305)2.72103248
109glycolipid catabolic process (GO:0019377)2.71989759
110negative regulation of myoblast differentiation (GO:0045662)2.71330115
111regulation of interferon-beta biosynthetic process (GO:0045357)2.69392611
112response to hepatocyte growth factor (GO:0035728)2.69175070
113cellular response to hepatocyte growth factor stimulus (GO:0035729)2.69175070
114response to host (GO:0075136)2.68460242
115response to host defenses (GO:0052200)2.68460242
116response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68460242
117G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.68021819
118cortical actin cytoskeleton organization (GO:0030866)2.67416653
119positive regulation of gliogenesis (GO:0014015)2.66936444
120negative regulation of mast cell activation (GO:0033004)2.63583732
121amino sugar catabolic process (GO:0046348)2.63207268
122positive regulation of macrophage cytokine production (GO:0060907)2.63011222
123negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.61481435
124positive regulation of macrophage differentiation (GO:0045651)2.60669609
125fibril organization (GO:0097435)2.60489973
126positive regulation of cellular amide metabolic process (GO:0034250)2.60133552
127negative regulation of homotypic cell-cell adhesion (GO:0034111)2.58692201
128response to muramyl dipeptide (GO:0032495)2.57989240
129negative regulation of leukocyte chemotaxis (GO:0002689)2.57875111
130extracellular matrix assembly (GO:0085029)2.57701367
131lipoxygenase pathway (GO:0019372)2.57331220
132positive regulation of regulated secretory pathway (GO:1903307)2.56855778
133myelin assembly (GO:0032288)2.56645668
134negative regulation of erythrocyte differentiation (GO:0045647)2.56344264
135extracellular fibril organization (GO:0043206)2.56117444
136glycerophospholipid catabolic process (GO:0046475)2.56096503
137neurotransmitter uptake (GO:0001504)2.55216872
138T-helper 1 type immune response (GO:0042088)2.54918055
139positive regulation of chemokine secretion (GO:0090197)2.53820208
140regulation of early endosome to late endosome transport (GO:2000641)2.53762023
141negative regulation of axon extension (GO:0030517)2.53564408
142membrane raft organization (GO:0031579)2.53044382
143positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.52744874
144response to thyroid hormone (GO:0097066)2.52560005
145neutrophil chemotaxis (GO:0030593)2.51797757
146regulation of type 2 immune response (GO:0002828)2.51302408
147negative regulation of platelet activation (GO:0010544)2.50833968
148regulation of beta-amyloid formation (GO:1902003)2.50155925
149positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49366278
150positive regulation of glial cell differentiation (GO:0045687)2.49271904
151peptide catabolic process (GO:0043171)2.49076590
152glial cell differentiation (GO:0010001)2.48648670
153response to redox state (GO:0051775)2.48506478
154cortical cytoskeleton organization (GO:0030865)2.47851354
155interferon-gamma-mediated signaling pathway (GO:0060333)2.46159286
156regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.46154693
157chondroitin sulfate biosynthetic process (GO:0030206)2.45727757
158Rap protein signal transduction (GO:0032486)2.45210372
159membrane assembly (GO:0071709)2.45161223
160platelet aggregation (GO:0070527)2.44600416
161neutrophil migration (GO:1990266)2.44344790
162production of molecular mediator involved in inflammatory response (GO:0002532)2.43959185
163establishment of mitochondrion localization (GO:0051654)2.43842743
164regulation of mononuclear cell migration (GO:0071675)2.42218441
165positive regulation of pseudopodium assembly (GO:0031274)2.40182838
166regulation of macrophage cytokine production (GO:0010935)2.39383374
167microglial cell activation (GO:0001774)2.39007463
168estrogen biosynthetic process (GO:0006703)2.37826815
169nucleotide transmembrane transport (GO:1901679)2.33674115
170negative regulation of leukocyte migration (GO:0002686)2.33231989
171regulation of osteoblast proliferation (GO:0033688)2.32823317
172Leydig cell differentiation (GO:0033327)2.32096597
173negative regulation of exocytosis (GO:0045920)2.30316708
174actin filament depolymerization (GO:0030042)2.29746611
175neuron cell-cell adhesion (GO:0007158)2.29694125
176enteric nervous system development (GO:0048484)2.29228407
177positive regulation of smooth muscle cell migration (GO:0014911)2.28716193
178peptidyl-tyrosine autophosphorylation (GO:0038083)2.26334358
179positive regulation of monocyte chemotaxis (GO:0090026)2.25879462
180positive regulation by symbiont of host defense response (GO:0052509)2.25878082
181modulation by symbiont of host defense response (GO:0052031)2.25878082
182modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25878082
183positive regulation by organism of defense response of other organism involved in symbiotic interact2.25878082
184modulation by symbiont of host immune response (GO:0052553)2.25878082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.55070178
2GBX2_23144817_ChIP-Seq_PC3_Human3.30886927
3MYB_21317192_ChIP-Seq_ERMYB_Mouse3.28405508
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.06413763
5NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00322157
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.98742841
7SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.94832313
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94171871
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77110331
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.63576270
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.57608202
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.56614167
13AR_21572438_ChIP-Seq_LNCaP_Human2.48994251
14* SPI1_23127762_ChIP-Seq_K562_Human2.42582616
15SCL_19346495_ChIP-Seq_HPC-7_Human2.33226943
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31476598
17NRF2_20460467_ChIP-Seq_MEFs_Mouse2.26491344
18NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.26491344
19OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.11755824
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07320448
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07253367
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04351514
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98957082
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.98309449
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97516712
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97166506
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.93288746
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.87991896
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87112994
30* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85469090
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77061836
32ER_23166858_ChIP-Seq_MCF-7_Human1.76988028
33* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76179032
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.75853556
35* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75506860
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74495781
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70806209
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65777703
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65406255
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65406255
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.65388745
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63979511
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63214298
44* CJUN_26792858_Chip-Seq_BT549_Human1.63128220
45SPI1_23547873_ChIP-Seq_NB4_Human1.60860085
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.60775763
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60445890
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.59491824
49VDR_24763502_ChIP-Seq_THP-1_Human1.59348688
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.58891716
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58885600
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58758756
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.56665695
54* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56365055
55* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56315142
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.55876079
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.54471244
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53870941
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53462068
60* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53301913
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52737645
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51352323
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50234593
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50157216
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.48877190
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48583774
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.47748563
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47309709
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45309853
70GATA1_19941826_ChIP-Seq_K562_Human1.42452133
71DROSHA_22980978_ChIP-Seq_HELA_Human1.41739835
72RUNX_20019798_ChIP-Seq_JUKART_Human1.41217482
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39562827
74* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39214145
75* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38350270
76VDR_24787735_ChIP-Seq_THP-1_Human1.38149138
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38058501
78PU_27001747_Chip-Seq_BMDM_Mouse1.37250681
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35980451
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35728164
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35713787
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32192247
83TP53_18474530_ChIP-ChIP_U2OS_Human1.29730489
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29228127
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28534213
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28290249
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.24508097
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24156152
89* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23667624
90GATA2_19941826_ChIP-Seq_K562_Human1.23516196
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.23056828
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22835301
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21223831
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21121869
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21038716
96CLOCK_20551151_ChIP-Seq_293T_Human1.21014197
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20671676
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.18857482
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17272923
100FUS_26573619_Chip-Seq_HEK293_Human1.16841577
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.14968211
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14396515
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11808854
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11023894
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.09468547
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.09398016
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09031616
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09017902
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08551445
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07881465
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07299223
112P300_19829295_ChIP-Seq_ESCs_Human1.06924843
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05942739
114* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05801569
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.05614478
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05462686
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05417319
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05195475
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05034412
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04365951
121GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02806844
122* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02610258
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02113209
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01523209
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01103604
126RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00559186
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00490139
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99189477
129* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98656849
130AHR_22903824_ChIP-Seq_MCF-7_Human0.97465070
131EOMES_21245162_ChIP-Seq_HESCs_Human0.96819919
132IGF1R_20145208_ChIP-Seq_DFB_Human0.96554095
133BP1_19119308_ChIP-ChIP_Hs578T_Human0.96495480
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95580368
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94843391
136* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94828958
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94643599
138SMAD4_21799915_ChIP-Seq_A2780_Human0.94372894
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.94093879
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93567616
141* SOX2_20726797_ChIP-Seq_SW620_Human0.92788522
142TCF7_22412390_ChIP-Seq_EML_Mouse0.91403365
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90682612
144* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90135551
145* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89385823
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89002917
147SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88398488
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88363190
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88326822
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88279277
151* STAT3_23295773_ChIP-Seq_U87_Human0.88104660
152* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87982106
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87808687
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87244771
155RXR_22108803_ChIP-Seq_LS180_Human0.87040223
156SOX9_26525672_Chip-Seq_HEART_Mouse0.87023787
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.86340079
158BRD4_25478319_ChIP-Seq_HGPS_Human0.85828910
159GATA1_22025678_ChIP-Seq_K562_Human0.85550600
160ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85382520
161NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84794304
162* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81824871
163SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79252171
164SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79252171
165VDR_21846776_ChIP-Seq_THP-1_Human0.78493675
166KDM2B_26808549_Chip-Seq_K562_Human0.77867360
167SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77321650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.72754015
2MP0000920_abnormal_myelination4.57246548
3MP0005171_absent_coat_pigmentation3.99155256
4MP0003303_peritoneal_inflammation3.91511476
5MP0003690_abnormal_glial_cell3.84918027
6MP0003724_increased_susceptibility_to3.84448933
7MP0005464_abnormal_platelet_physiology3.68569559
8MP0003136_yellow_coat_color3.15104568
9MP0003950_abnormal_plasma_membrane3.13721531
10MP0001958_emphysema3.05580267
11MP0003436_decreased_susceptibility_to2.91087561
12MP0005058_abnormal_lysosome_morphology2.80192243
13MP0003634_abnormal_glial_cell2.77035296
14MP0001835_abnormal_antigen_presentation2.60069227
15MP0003300_gastrointestinal_ulcer2.57597339
16MP0008004_abnormal_stomach_pH2.51806231
17MP0003191_abnormal_cellular_cholesterol2.27754348
18MP0003279_aneurysm2.24864245
19MP0004885_abnormal_endolymph2.19763895
20MP0005503_abnormal_tendon_morphology2.10486200
21MP0004134_abnormal_chest_morphology2.06981016
22MP0003828_pulmonary_edema2.01249312
23MP0009384_cardiac_valve_regurgitation1.97699783
24MP0006054_spinal_hemorrhage1.96973828
25MP0005623_abnormal_meninges_morphology1.95021459
26MP0003632_abnormal_nervous_system1.92827586
27MP0005167_abnormal_blood-brain_barrier1.92470990
28MP0003566_abnormal_cell_adhesion1.91979646
29MP0000778_abnormal_nervous_system1.90200266
30MP0005000_abnormal_immune_tolerance1.89973168
31MP0009764_decreased_sensitivity_to1.88398414
32MP0002295_abnormal_pulmonary_circulatio1.88343998
33MP0004510_myositis1.88272144
34MP0003329_amyloid_beta_deposits1.86314599
35MP0009785_altered_susceptibility_to1.84184755
36MP0005409_darkened_coat_color1.82901121
37MP0005025_abnormal_response_to1.81215232
38MP0003705_abnormal_hypodermis_morpholog1.74294824
39MP0004272_abnormal_basement_membrane1.73705290
40MP0002452_abnormal_antigen_presenting1.69106197
41MP0001790_abnormal_immune_system1.68423486
42MP0005387_immune_system_phenotype1.68423486
43MP0004742_abnormal_vestibular_system1.68063408
44MP0001299_abnormal_eye_distance/1.66152759
45MP0005671_abnormal_response_to1.64268892
46MP0000604_amyloidosis1.58683503
47MP0001905_abnormal_dopamine_level1.56415619
48MP0001545_abnormal_hematopoietic_system1.54394148
49MP0005397_hematopoietic_system_phenotyp1.54394148
50MP0000685_abnormal_immune_system1.54112911
51MP0004858_abnormal_nervous_system1.53940465
52MP0003172_abnormal_lysosome_physiology1.51637378
53MP0002877_abnormal_melanocyte_morpholog1.51344082
54MP0002723_abnormal_immune_serum1.51178602
55MP0001485_abnormal_pinna_reflex1.49920944
56MP0009840_abnormal_foam_cell1.49243405
57MP0000858_altered_metastatic_potential1.49029848
58MP0001853_heart_inflammation1.47552313
59MP0004947_skin_inflammation1.44791852
60MP0001529_abnormal_vocalization1.35645267
61MP0009250_abnormal_appendicular_skeleto1.35489111
62MP0002420_abnormal_adaptive_immunity1.35000015
63MP0001819_abnormal_immune_cell1.34556083
64MP0001800_abnormal_humoral_immune1.34443915
65MP0005388_respiratory_system_phenotype1.34153286
66MP0002133_abnormal_respiratory_system1.34153286
67MP0003091_abnormal_cell_migration1.32903320
68MP0005166_decreased_susceptibility_to1.32698029
69MP0001177_atelectasis1.31442451
70MP0004883_abnormal_blood_vessel1.30139123
71MP0000383_abnormal_hair_follicle1.29487149
72MP0005275_abnormal_skin_tensile1.29033678
73MP0001845_abnormal_inflammatory_respons1.27956120
74MP0005023_abnormal_wound_healing1.27626180
75MP0005164_abnormal_response_to1.27303743
76MP0001486_abnormal_startle_reflex1.25902001
77MP0004270_analgesia1.24020051
78MP0003453_abnormal_keratinocyte_physiol1.23168348
79MP0002419_abnormal_innate_immunity1.21551644
80MP0000343_altered_response_to1.21353738
81MP0000372_irregular_coat_pigmentation1.20887764
82MP0000249_abnormal_blood_vessel1.18781278
83MP0010155_abnormal_intestine_physiology1.13993407
84MP0003075_altered_response_to1.13262145
85MP0002405_respiratory_system_inflammati1.10143223
86MP0005165_increased_susceptibility_to1.10054145
87MP0004142_abnormal_muscle_tone1.07383537
88MP0005508_abnormal_skeleton_morphology1.06878371
89MP0003631_nervous_system_phenotype1.05280240
90MP0000465_gastrointestinal_hemorrhage1.03814388
91MP0002064_seizures1.02760204
92MP0003183_abnormal_peptide_metabolism1.01306596
93MP0010678_abnormal_skin_adnexa1.01179636
94MP0000428_abnormal_craniofacial_morphol1.00781140
95MP0000015_abnormal_ear_pigmentation0.98947439
96MP0005595_abnormal_vascular_smooth0.98704906
97MP0008469_abnormal_protein_level0.98144458
98MP0001533_abnormal_skeleton_physiology0.97211549
99MP0008874_decreased_physiological_sensi0.93997044
100MP0002272_abnormal_nervous_system0.91856394
101MP0004859_abnormal_synaptic_plasticity0.91638759
102MP0001849_ear_inflammation0.90982724
103MP0003656_abnormal_erythrocyte_physiolo0.90509293
104MP0003880_abnormal_central_pattern0.90493240
105MP0001963_abnormal_hearing_physiology0.89128436
106MP0002933_joint_inflammation0.88469415
107MP0009763_increased_sensitivity_to0.88085804
108MP0002148_abnormal_hypersensitivity_rea0.87550256
109MP0002998_abnormal_bone_remodeling0.87480315
110MP0000733_abnormal_muscle_development0.87195149
111MP0001542_abnormal_bone_strength0.86933594
112MP0002229_neurodegeneration0.86650583
113MP0000716_abnormal_immune_system0.86227698
114MP0005410_abnormal_fertilization0.85858116
115MP0000749_muscle_degeneration0.83341389
116MP0001851_eye_inflammation0.82938384
117MP0005390_skeleton_phenotype0.82401485
118MP0002896_abnormal_bone_mineralization0.80459048
119MP0000955_abnormal_spinal_cord0.80153703
120MP0002882_abnormal_neuron_morphology0.79372094
121MP0000566_synostosis0.78228722
122MP0002398_abnormal_bone_marrow0.77198261
123MP0000569_abnormal_digit_pigmentation0.77110677
124MP0005248_abnormal_Harderian_gland0.75654792
125MP0005310_abnormal_salivary_gland0.74146176
126MP0001915_intracranial_hemorrhage0.72374791
127MP0003937_abnormal_limbs/digits/tail_de0.70427526
128MP0002332_abnormal_exercise_endurance0.69814040
129MP0002090_abnormal_vision0.69737933
130MP0002429_abnormal_blood_cell0.69155772
131MP0001346_abnormal_lacrimal_gland0.69134247
132MP0009765_abnormal_xenobiotic_induced0.68563003
133MP0002938_white_spotting0.68269429
134MP0003448_altered_tumor_morphology0.67710741
135MP0002108_abnormal_muscle_morphology0.66670538
136MP0003633_abnormal_nervous_system0.66595059
137MP0005257_abnormal_intraocular_pressure0.66421201
138MP0005197_abnormal_uvea_morphology0.66410569
139MP0000647_abnormal_sebaceous_gland0.65573422
140MP0001879_abnormal_lymphatic_vessel0.64738332
141MP0003385_abnormal_body_wall0.64009035
142MP0000026_abnormal_inner_ear0.63345647
143MP0008260_abnormal_autophagy0.63289661
144MP0009278_abnormal_bone_marrow0.63275427
145MP0000681_abnormal_thyroid_gland0.62022889
146MP0000762_abnormal_tongue_morphology0.60884176
147MP0010352_gastrointestinal_tract_polyps0.59513564
148MP0008569_lethality_at_weaning0.58912477
149MP0002115_abnormal_skeleton_extremities0.58439874
150MP0002089_abnormal_postnatal_growth/wei0.58296150
151MP0005408_hypopigmentation0.58069888
152MP0005451_abnormal_body_composition0.58010361
153MP0000462_abnormal_digestive_system0.56950855
154MP0001663_abnormal_digestive_system0.56716046
155MP0004130_abnormal_muscle_cell0.56116309
156MP0002066_abnormal_motor_capabilities/c0.55836582
157MP0006082_CNS_inflammation0.55555244
158MP0005646_abnormal_pituitary_gland0.55537963
159MP0002152_abnormal_brain_morphology0.55491325
160MP0000767_abnormal_smooth_muscle0.55450819
161MP0003795_abnormal_bone_structure0.54999789
162MP0002736_abnormal_nociception_after0.54913177

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.55983231
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.55983231
3Purpura (HP:0000979)4.48477462
4Neurofibrillary tangles (HP:0002185)4.41681182
5Prolonged bleeding time (HP:0003010)4.35941892
6Eczematoid dermatitis (HP:0000976)4.35414110
7Petechiae (HP:0000967)4.27419679
8Recurrent bacterial skin infections (HP:0005406)4.24335968
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.00791491
10Increased cerebral lipofuscin (HP:0011813)3.86124149
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.85988278
12Abnormal platelet volume (HP:0011876)3.71104367
13Spontaneous hematomas (HP:0007420)3.67083117
14Increased mean platelet volume (HP:0011877)3.64995085
15Vascular tortuosity (HP:0004948)3.52322895
16Aplasia involving bones of the upper limbs (HP:0009823)3.50075486
17Aplasia of the phalanges of the hand (HP:0009802)3.50075486
18Aplasia involving bones of the extremities (HP:0009825)3.50075486
19Epistaxis (HP:0000421)3.47759917
20Menorrhagia (HP:0000132)3.42530883
21Gingival bleeding (HP:0000225)3.41727898
22Akinesia (HP:0002304)3.38904773
23Recurrent gram-negative bacterial infections (HP:0005420)3.33547846
24Premature rupture of membranes (HP:0001788)3.33407820
25Premature skin wrinkling (HP:0100678)3.30577815
26White forelock (HP:0002211)3.28806726
27Abnormal auditory evoked potentials (HP:0006958)3.23758858
28Loss of speech (HP:0002371)3.10410206
29Patchy hypopigmentation of hair (HP:0011365)3.10153823
30Abnormality of the corticospinal tract (HP:0002492)3.01716374
31Abnormality of the vasculature of the conjunctiva (HP:0008054)2.93574565
32Myocardial infarction (HP:0001658)2.93316689
33Peripheral hypomyelination (HP:0007182)2.91226307
34Cerebral hypomyelination (HP:0006808)2.84893036
35Disinhibition (HP:0000734)2.81111394
36Cerebral inclusion bodies (HP:0100314)2.80010040
37Sensory axonal neuropathy (HP:0003390)2.78503551
38Abnormality of dentin (HP:0010299)2.73111756
39Clumsiness (HP:0002312)2.72430885
40Obstructive lung disease (HP:0006536)2.69661470
41Chronic obstructive pulmonary disease (HP:0006510)2.69661470
42Supranuclear gaze palsy (HP:0000605)2.61439242
43Parakeratosis (HP:0001036)2.59665856
44Peritonitis (HP:0002586)2.58337946
45Absent frontal sinuses (HP:0002688)2.54503865
46Conjunctival telangiectasia (HP:0000524)2.53170142
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50967508
48Abnormality of liposaccharide metabolism (HP:0010968)2.49133194
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.49133194
50Abnormality of glycolipid metabolism (HP:0010969)2.49133194
51Mutism (HP:0002300)2.47611450
52Mediastinal lymphadenopathy (HP:0100721)2.46355747
53Onion bulb formation (HP:0003383)2.45618484
54Systemic lupus erythematosus (HP:0002725)2.44549294
55Megalencephaly (HP:0001355)2.43914498
56Coronal craniosynostosis (HP:0004440)2.40778081
57Gingivitis (HP:0000230)2.40554329
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.38109159
59Wormian bones (HP:0002645)2.37381317
60Recurrent skin infections (HP:0001581)2.36772444
61Hepatosplenomegaly (HP:0001433)2.35066341
62Pulmonary artery stenosis (HP:0004415)2.32863815
63Vacuolated lymphocytes (HP:0001922)2.30496783
64Elevated erythrocyte sedimentation rate (HP:0003565)2.30031031
65Hypoplastic left heart (HP:0004383)2.28567741
66Impaired platelet aggregation (HP:0003540)2.28488917
67Abnormal platelet function (HP:0011869)2.28488917
68Intention tremor (HP:0002080)2.28061927
69Follicular hyperkeratosis (HP:0007502)2.24519993
70Hypoplasia of the iris (HP:0007676)2.23215466
71Nuclear cataract (HP:0100018)2.22900393
72Spondylolisthesis (HP:0003302)2.22387106
73Retinal dysplasia (HP:0007973)2.22111286
74Hemiplegia (HP:0002301)2.20175306
75Urinary glycosaminoglycan excretion (HP:0003541)2.19637073
76Mucopolysacchariduria (HP:0008155)2.19637073
77Osteolytic defects of the hand bones (HP:0009699)2.19277771
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.19277771
79Broad metatarsal (HP:0001783)2.19243153
80Axonal loss (HP:0003447)2.18956849
81Interstitial pulmonary disease (HP:0006530)2.18119489
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18097210
83Abnormality of polysaccharide metabolism (HP:0011012)2.18097210
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18097210
85Arterial tortuosity (HP:0005116)2.17547950
86Asymmetry of the thorax (HP:0001555)2.16661373
87Absent septum pellucidum (HP:0001331)2.16047125
88Basal ganglia calcification (HP:0002135)2.15948744
89Stomatitis (HP:0010280)2.15885661
90Aortic aneurysm (HP:0004942)2.13894893
91Dysostosis multiplex (HP:0000943)2.12798204
92Hypoplastic pelvis (HP:0008839)2.11510771
93Cellulitis (HP:0100658)2.09858638
94Neuronal loss in central nervous system (HP:0002529)2.09662674
95Gowers sign (HP:0003391)2.09178412
96Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.09124424
97Mitral stenosis (HP:0001718)2.07646825
98Bladder diverticulum (HP:0000015)2.06976486
99Mitral regurgitation (HP:0001653)2.06617522
100Vertebral compression fractures (HP:0002953)2.06439072
101Apathy (HP:0000741)2.05849290
102Bruising susceptibility (HP:0000978)2.05763910
103Morphological abnormality of the inner ear (HP:0011390)2.05573181
104Polycythemia (HP:0001901)2.04445011
105Alacrima (HP:0000522)2.04120568
106Humeroradial synostosis (HP:0003041)2.04016734
107Synostosis involving the elbow (HP:0003938)2.04016734
108Diminished motivation (HP:0000745)2.03430298
109Urticaria (HP:0001025)2.03250501
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03202758
111Retrobulbar optic neuritis (HP:0100654)2.03182979
112Optic neuritis (HP:0100653)2.03182979
113Stridor (HP:0010307)2.02230813
114Relative macrocephaly (HP:0004482)2.00431045
115Aortic dissection (HP:0002647)1.99771950
116Buphthalmos (HP:0000557)1.99453562
117Shallow orbits (HP:0000586)1.98859491
118Diminished movement (HP:0002374)1.98343074
119Segmental peripheral demyelination/remyelination (HP:0003481)1.96968323
120Recurrent abscess formation (HP:0002722)1.96637646
121Stomach cancer (HP:0012126)1.96580540
122Hematochezia (HP:0002573)1.96172959
123Glomerulonephritis (HP:0000099)1.95599498
124Pulmonary infiltrates (HP:0002113)1.94875378
125Septo-optic dysplasia (HP:0100842)1.94033761
126Amyloidosis (HP:0011034)1.91326588
127Hypoplastic heart (HP:0001961)1.91081982
128Arterial thrombosis (HP:0004420)1.88686575
129Orchitis (HP:0100796)1.88486692
130Osteomyelitis (HP:0002754)1.85785868
131Abnormality of incisor morphology (HP:0011063)1.85645675
132Recurrent fungal infections (HP:0002841)1.85256817
133Hemoptysis (HP:0002105)1.84854139
134Upper motor neuron abnormality (HP:0002127)1.83912664
135Chest pain (HP:0100749)1.83482010
136Scapular winging (HP:0003691)1.83110736
137Termporal pattern (HP:0011008)1.82717896
138Insidious onset (HP:0003587)1.82717896
139Episodic fever (HP:0001954)1.82358683
140Heterochromia iridis (HP:0001100)1.82048018
141Prostate neoplasm (HP:0100787)1.81695112
142Ankle clonus (HP:0011448)1.81514092
143Vertigo (HP:0002321)1.80548899
144Bone pain (HP:0002653)1.78275784
145Gastrointestinal infarctions (HP:0005244)1.78070929
146Dilatation of the ascending aorta (HP:0005111)1.77804579
147Myositis (HP:0100614)1.77703573
148Keratoconjunctivitis sicca (HP:0001097)1.76697980
149Lissencephaly (HP:0001339)1.75991557
150Thick nail (HP:0001805)1.75969675
151Meningitis (HP:0001287)1.75575124
152Abnormality of molar morphology (HP:0011070)1.75296086
153Abnormality of molar (HP:0011077)1.75296086
154Abnormality of macrophages (HP:0004311)1.75180794
155Short hallux (HP:0010109)1.75055535
156Soft skin (HP:0000977)1.74772301
157Pathologic fracture (HP:0002756)1.73308377
158Abnormality of the frontal sinuses (HP:0002687)1.72603577
159J-shaped sella turcica (HP:0002680)1.71676659
160Bell-shaped thorax (HP:0001591)1.70825119
161Esophageal atresia (HP:0002032)1.70703233
162Diplopia (HP:0000651)1.68034183
163Abnormality of binocular vision (HP:0011514)1.68034183
164Prolonged neonatal jaundice (HP:0006579)1.67686174
165Abnormality of the septum pellucidum (HP:0007375)1.67652220
166Dementia (HP:0000726)1.67630530
167Syringomyelia (HP:0003396)1.67577276
168Spinal cord lesions (HP:0100561)1.67577276
169Mucosal telangiectasiae (HP:0100579)1.66683648
170Cerebral ischemia (HP:0002637)1.66243530
171Increased CSF protein (HP:0002922)1.66111951
172Femoral bowing (HP:0002980)1.64846903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.44703569
2RIPK44.52114650
3STK393.76361669
4TNIK3.53992472
5EPHB12.98201738
6LIMK12.90386584
7OXSR12.84982190
8BCR2.80508838
9CASK2.49712127
10TYK22.47849579
11FGFR22.44293817
12CSK2.40387960
13PKN12.24599006
14IRAK32.21402391
15PBK2.20137402
16CLK12.09257869
17MET1.97437599
18ROCK21.96291697
19ZAP701.82110266
20MAP2K31.81604256
21NEK61.81257182
22MAPKAPK51.71637719
23TGFBR21.69848321
24JAK11.67379658
25MAP3K31.61296092
26MUSK1.59316393
27ERBB31.59073330
28MKNK11.54800831
29TRPM71.52639493
30NEK91.51165044
31IRAK41.42845947
32TESK11.41286486
33KSR21.39907786
34HCK1.38808187
35JAK31.35197304
36BMPR1B1.34136460
37ERN11.31920023
38CSNK1A1L1.29937598
39CSNK1G31.29857946
40UHMK11.29075864
41KIT1.28224312
42JAK21.27705544
43PAK61.26793455
44PIK3CG1.25884439
45SYK1.25164109
46TESK21.23650485
47TYRO31.22987191
48NTRK11.19828713
49EPHA31.16916301
50PRKD31.15715149
51BTK1.13855643
52SGK4941.13140726
53SGK2231.13140726
54LYN1.11297268
55MAPK131.08426987
56CDK191.06683172
57IRAK11.06429098
58KSR11.04797295
59SIK31.03771952
60TNK21.03353737
61PAK31.00434400
62MARK11.00227092
63TAOK21.00126419
64PLK20.99678692
65MAP3K20.99323760
66ROCK10.97134754
67FGR0.96475665
68MAP3K60.95968586
69CSNK1G20.95918697
70WNK10.95645621
71MAP3K10.95220413
72MATK0.94387619
73CDK140.91340880
74NTRK20.91133234
75TAOK10.89507481
76RET0.89237322
77CDK180.88572049
78TBK10.88358213
79GRK70.87898572
80CDK150.87321724
81TEC0.86438093
82DYRK20.86226081
83CSNK1G10.86161257
84DDR20.85512225
85MOS0.85422014
86MAP3K130.83333610
87MKNK20.82656804
88CSF1R0.81782418
89ILK0.81773320
90NTRK30.81544824
91CDC42BPA0.79706329
92RIPK10.78909583
93PDGFRB0.78191855
94BLK0.77752249
95ICK0.76714249
96YES10.76002630
97EIF2AK10.75926677
98PRKCH0.75729244
99CDK11A0.74869067
100PIK3CA0.74728193
101PIM20.74381090
102IKBKE0.73857914
103CAMK2D0.73106754
104DMPK0.72398959
105RAF10.71888273
106PDPK10.71424478
107ARAF0.70180051
108FER0.69941193
109CAMK2B0.69892238
110CAMKK20.68776678
111SGK30.68445019
112PRKCE0.65134588
113MAP3K50.65048501
114MAP3K140.64696236
115GRK60.63028327
116LRRK20.62183108
117MYLK0.60511989
118PAK20.59632232
119BMX0.58768464
120PDGFRA0.58126349
121MAPK120.56953291
122ERBB40.56406963
123SGK20.56005623
124CDK60.54541310
125MST40.54316451
126PDK10.54302135
127LCK0.53958646
128IKBKB0.53627312
129ABL10.53193884
130BMPR20.51755073
131EPHB20.49644879
132MARK20.49043806
133CDK50.48842184
134FYN0.48031145
135PRKACB0.47515928
136PRKG10.47114898
137TAOK30.46838003
138MAPK70.46769267
139CAMK1G0.46562498
140ZAK0.46407103
141PAK10.45342704
142GSK3A0.44679357
143PTK20.44339842
144MAP3K120.43127387
145ERBB20.43058511
146WNK40.42771943
147PRKD10.40886808
148PRKCQ0.40439040
149FES0.39600763
150PAK40.39544938
151PTK2B0.38232526
152ABL20.37041538
153SRC0.35874542
154CAMK2G0.34657637
155CAMK2A0.34201403
156PHKG10.33884723
157PHKG20.33884723
158IRAK20.32971029
159FGFR10.32852596
160TTN0.32101054
161MAPKAPK20.31555699
162STK100.30913089

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.25106040
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.78426703
3Fatty acid elongation_Homo sapiens_hsa000622.70392709
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26220695
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21048971
6Lysosome_Homo sapiens_hsa041422.19611517
7Ether lipid metabolism_Homo sapiens_hsa005652.13057848
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.05394986
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.92555416
10Sphingolipid metabolism_Homo sapiens_hsa006001.91446143
11Axon guidance_Homo sapiens_hsa043601.88255737
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81853028
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.77345074
14Phagosome_Homo sapiens_hsa041451.73057192
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60414397
16Malaria_Homo sapiens_hsa051441.52967968
17Asthma_Homo sapiens_hsa053101.45620790
18Hematopoietic cell lineage_Homo sapiens_hsa046401.39746583
19Legionellosis_Homo sapiens_hsa051341.35935004
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.35576813
21Allograft rejection_Homo sapiens_hsa053301.34559910
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33273940
23Graft-versus-host disease_Homo sapiens_hsa053321.28361308
24Sphingolipid signaling pathway_Homo sapiens_hsa040711.27214583
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26435703
26ECM-receptor interaction_Homo sapiens_hsa045121.25097271
27Other glycan degradation_Homo sapiens_hsa005111.24430784
28Sulfur metabolism_Homo sapiens_hsa009201.24157774
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24017521
30Renal cell carcinoma_Homo sapiens_hsa052111.23774062
31Rheumatoid arthritis_Homo sapiens_hsa053231.23182288
32Vitamin B6 metabolism_Homo sapiens_hsa007501.22224516
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21626405
34Focal adhesion_Homo sapiens_hsa045101.21564983
35Shigellosis_Homo sapiens_hsa051311.14058528
36Arachidonic acid metabolism_Homo sapiens_hsa005901.13300458
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.13286843
38Pertussis_Homo sapiens_hsa051331.11501557
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11333860
40Salmonella infection_Homo sapiens_hsa051321.09716578
41Influenza A_Homo sapiens_hsa051641.08021924
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07959756
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07863064
44Collecting duct acid secretion_Homo sapiens_hsa049661.05414517
45TNF signaling pathway_Homo sapiens_hsa046681.04969792
46Tight junction_Homo sapiens_hsa045301.04867001
47Protein export_Homo sapiens_hsa030601.04342376
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01957797
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00858331
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.99927415
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97822102
52Antigen processing and presentation_Homo sapiens_hsa046120.96078790
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92711334
54* Endocytosis_Homo sapiens_hsa041440.92511841
55Ras signaling pathway_Homo sapiens_hsa040140.90312082
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88587076
57Notch signaling pathway_Homo sapiens_hsa043300.88137662
58VEGF signaling pathway_Homo sapiens_hsa043700.87415711
59Vibrio cholerae infection_Homo sapiens_hsa051100.87219352
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.87059118
61Viral myocarditis_Homo sapiens_hsa054160.87016249
62Pancreatic cancer_Homo sapiens_hsa052120.86798013
63Type I diabetes mellitus_Homo sapiens_hsa049400.85242742
64Proteoglycans in cancer_Homo sapiens_hsa052050.84758952
65Measles_Homo sapiens_hsa051620.84251063
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81943557
67Hepatitis B_Homo sapiens_hsa051610.81577661
68Leishmaniasis_Homo sapiens_hsa051400.79590350
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79443912
70Glioma_Homo sapiens_hsa052140.78386288
71Hippo signaling pathway_Homo sapiens_hsa043900.77983546
72Acute myeloid leukemia_Homo sapiens_hsa052210.77682487
73ErbB signaling pathway_Homo sapiens_hsa040120.76633829
74Hepatitis C_Homo sapiens_hsa051600.74605037
75Dilated cardiomyopathy_Homo sapiens_hsa054140.74515602
76Chemokine signaling pathway_Homo sapiens_hsa040620.74468430
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73120125
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.73117211
79B cell receptor signaling pathway_Homo sapiens_hsa046620.72519551
80Melanoma_Homo sapiens_hsa052180.72240348
81African trypanosomiasis_Homo sapiens_hsa051430.72142959
82Tuberculosis_Homo sapiens_hsa051520.71400479
83Gap junction_Homo sapiens_hsa045400.71387062
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.70813540
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70723100
86Bladder cancer_Homo sapiens_hsa052190.70697434
87Long-term depression_Homo sapiens_hsa047300.70106476
88Prostate cancer_Homo sapiens_hsa052150.69850341
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69475784
90Dorso-ventral axis formation_Homo sapiens_hsa043200.68939723
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68416583
92Amoebiasis_Homo sapiens_hsa051460.67073621
93TGF-beta signaling pathway_Homo sapiens_hsa043500.66174812
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64742579
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64650882
96Prolactin signaling pathway_Homo sapiens_hsa049170.64222154
97Chronic myeloid leukemia_Homo sapiens_hsa052200.64150189
98Serotonergic synapse_Homo sapiens_hsa047260.64040350
99Endometrial cancer_Homo sapiens_hsa052130.63697033
100Choline metabolism in cancer_Homo sapiens_hsa052310.63500241
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.61578250
102Autoimmune thyroid disease_Homo sapiens_hsa053200.61566229
103Estrogen signaling pathway_Homo sapiens_hsa049150.61149227
104Platelet activation_Homo sapiens_hsa046110.60909734
105GnRH signaling pathway_Homo sapiens_hsa049120.60753505
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59962950
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59319437
108HIF-1 signaling pathway_Homo sapiens_hsa040660.56708810
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56564861
110T cell receptor signaling pathway_Homo sapiens_hsa046600.56132258
111Osteoclast differentiation_Homo sapiens_hsa043800.55245308
112Glutathione metabolism_Homo sapiens_hsa004800.54673110
113Rap1 signaling pathway_Homo sapiens_hsa040150.54599359
114MicroRNAs in cancer_Homo sapiens_hsa052060.54303805
115Glutamatergic synapse_Homo sapiens_hsa047240.54277947
116Staphylococcus aureus infection_Homo sapiens_hsa051500.53711759
117Herpes simplex infection_Homo sapiens_hsa051680.53445791
118Toxoplasmosis_Homo sapiens_hsa051450.53120221
119N-Glycan biosynthesis_Homo sapiens_hsa005100.52993531
120Ovarian steroidogenesis_Homo sapiens_hsa049130.52497944
121Fatty acid biosynthesis_Homo sapiens_hsa000610.52187582
122Pathways in cancer_Homo sapiens_hsa052000.51375612
123Colorectal cancer_Homo sapiens_hsa052100.51274454
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50790146
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49984523
126Complement and coagulation cascades_Homo sapiens_hsa046100.48906705
127Apoptosis_Homo sapiens_hsa042100.48106435
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46965818
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46809533
130Synaptic vesicle cycle_Homo sapiens_hsa047210.46192794
131Hedgehog signaling pathway_Homo sapiens_hsa043400.43991411
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43016286
133Adherens junction_Homo sapiens_hsa045200.42770092
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42727725
135Prion diseases_Homo sapiens_hsa050200.41691633
136Small cell lung cancer_Homo sapiens_hsa052220.41147502
137Linoleic acid metabolism_Homo sapiens_hsa005910.41050720
138Basal cell carcinoma_Homo sapiens_hsa052170.39934711
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38841279
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.38175681
141Non-small cell lung cancer_Homo sapiens_hsa052230.36268480

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