RAB33A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.19849806
2axon ensheathment in central nervous system (GO:0032291)9.19849806
3fatty acid elongation (GO:0030497)6.80398890
4myelination (GO:0042552)5.97601050
5axon ensheathment (GO:0008366)5.96022708
6ensheathment of neurons (GO:0007272)5.96022708
7pyrimidine nucleobase catabolic process (GO:0006208)5.70114995
8long-chain fatty acid biosynthetic process (GO:0042759)5.65692541
9presynaptic membrane assembly (GO:0097105)4.77144496
10presynaptic membrane organization (GO:0097090)4.73996421
11neuron cell-cell adhesion (GO:0007158)4.59225354
12sequestering of actin monomers (GO:0042989)4.53447561
13negative regulation of neurotransmitter secretion (GO:0046929)4.47124946
14regulation of collateral sprouting (GO:0048670)4.44566781
15cholesterol biosynthetic process (GO:0006695)4.40610471
16nucleobase catabolic process (GO:0046113)4.33747407
17gamma-aminobutyric acid transport (GO:0015812)4.33449895
18substantia nigra development (GO:0021762)4.28575820
19negative regulation of neurotransmitter transport (GO:0051589)4.26211738
20establishment of mitochondrion localization (GO:0051654)4.23767075
21oligodendrocyte differentiation (GO:0048709)4.14472620
22synaptic vesicle maturation (GO:0016188)4.06454781
23apical protein localization (GO:0045176)4.04617932
24neurofilament cytoskeleton organization (GO:0060052)4.00006731
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.93064636
26negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.90754617
27glycerophospholipid catabolic process (GO:0046475)3.85638563
28sterol biosynthetic process (GO:0016126)3.81642316
29positive regulation of amino acid transport (GO:0051957)3.76466144
30response to redox state (GO:0051775)3.73496014
31transmission of nerve impulse (GO:0019226)3.71118283
32asymmetric protein localization (GO:0008105)3.64755375
33negative regulation of axonogenesis (GO:0050771)3.60721031
34postsynaptic membrane organization (GO:0001941)3.57292855
35negative regulation of protein localization to cell surface (GO:2000009)3.56484825
36isoprenoid biosynthetic process (GO:0008299)3.53829409
37photoreceptor cell differentiation (GO:0046530)3.52317763
38eye photoreceptor cell differentiation (GO:0001754)3.52317763
39cerebellar granule cell differentiation (GO:0021707)3.50361757
40myelin maintenance (GO:0043217)3.46406091
41creatine metabolic process (GO:0006600)3.42961373
42cerebral cortex radially oriented cell migration (GO:0021799)3.41318957
43astrocyte development (GO:0014002)3.39719269
44cellular response to epinephrine stimulus (GO:0071872)3.36144543
45glutamate receptor signaling pathway (GO:0007215)3.34287454
46long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.30869140
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26865596
48chaperone-mediated protein transport (GO:0072321)3.24037132
49adult walking behavior (GO:0007628)3.23998201
50regulation of synaptic vesicle transport (GO:1902803)3.23610074
51neuronal action potential propagation (GO:0019227)3.22658208
52regulation of glutamate secretion (GO:0014048)3.22395417
53negative regulation of axon extension (GO:0030517)3.21556176
54limb bud formation (GO:0060174)3.21391803
55L-amino acid import (GO:0043092)3.21064197
56neuron recognition (GO:0008038)3.21055779
57adhesion of symbiont to host cell (GO:0044650)3.19565951
58virion attachment to host cell (GO:0019062)3.19565951
59behavioral response to nicotine (GO:0035095)3.16393087
60response to epinephrine (GO:0071871)3.15829230
61positive regulation of action potential (GO:0045760)3.14786846
62long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.14552966
63neuronal ion channel clustering (GO:0045161)3.13735935
64positive regulation of oligodendrocyte differentiation (GO:0048714)3.13207174
65protein complex biogenesis (GO:0070271)3.10659581
66peptidyl-tyrosine autophosphorylation (GO:0038083)3.10594881
67glutamate secretion (GO:0014047)3.09991414
68establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06849521
69mitochondrion transport along microtubule (GO:0047497)3.06849521
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.03630311
71peripheral nervous system axon ensheathment (GO:0032292)3.02740703
72myelination in peripheral nervous system (GO:0022011)3.02740703
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.02048094
74ATP hydrolysis coupled proton transport (GO:0015991)3.02048094
75regulation of synapse structural plasticity (GO:0051823)3.01959395
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01060972
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00519145
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99820731
79neural nucleus development (GO:0048857)2.96860932
80protein localization to synapse (GO:0035418)2.94998170
81vocalization behavior (GO:0071625)2.94317724
82response to hepatocyte growth factor (GO:0035728)2.93863853
83cellular response to hepatocyte growth factor stimulus (GO:0035729)2.93863853
84response to methylmercury (GO:0051597)2.93012569
85neurotransmitter secretion (GO:0007269)2.92952453
86neurotransmitter-gated ion channel clustering (GO:0072578)2.91534606
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.91456205
88NADH dehydrogenase complex assembly (GO:0010257)2.91456205
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91456205
90Arp2/3 complex-mediated actin nucleation (GO:0034314)2.87292215
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87173130
92negative regulation of microtubule polymerization (GO:0031115)2.86982909
93negative regulation of telomere maintenance (GO:0032205)2.86760900
94short-term memory (GO:0007614)2.85685899
95synaptic vesicle exocytosis (GO:0016079)2.83432933
96negative regulation of heart rate (GO:0010459)2.83129968
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.82782643
98protein insertion into membrane (GO:0051205)2.82015045
99protein neddylation (GO:0045116)2.81609346
100protein palmitoylation (GO:0018345)2.81261454
101fatty-acyl-CoA biosynthetic process (GO:0046949)2.79817149
102regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79812468
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79482953
104neuron remodeling (GO:0016322)2.78953748
105response to auditory stimulus (GO:0010996)2.77751557
106DNA deamination (GO:0045006)2.77519994
107exploration behavior (GO:0035640)2.75964036
108mitochondrial respiratory chain complex assembly (GO:0033108)2.75853288
109peripheral nervous system development (GO:0007422)2.74961630
110membrane assembly (GO:0071709)2.74835044
111positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74550721
112peptidyl-cysteine modification (GO:0018198)2.72885156
113axonal fasciculation (GO:0007413)2.72745715
114regulation of neurotransmitter secretion (GO:0046928)2.70824840
115mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69493091
116auditory behavior (GO:0031223)2.69064499
117positive regulation of mitochondrial fission (GO:0090141)2.68673800
118protein localization to cilium (GO:0061512)2.68533138
119detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.68262420
120detection of temperature stimulus involved in sensory perception (GO:0050961)2.68262420
121dendritic spine morphogenesis (GO:0060997)2.67841040
122regulation of synaptic vesicle exocytosis (GO:2000300)2.67102055
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66506236
124regulation of amino acid transport (GO:0051955)2.65804614
125synapse assembly (GO:0007416)2.64799312
126GPI anchor biosynthetic process (GO:0006506)2.64110450
127cellular response to monoamine stimulus (GO:0071868)2.63534849
128cellular response to catecholamine stimulus (GO:0071870)2.63534849
129positive regulation of neurotransmitter secretion (GO:0001956)2.62465584
130regulation of synaptic transmission, GABAergic (GO:0032228)2.61477358
131regulation of catecholamine metabolic process (GO:0042069)2.61435080
132regulation of dopamine metabolic process (GO:0042053)2.61435080
133mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.61292566
134GPI anchor metabolic process (GO:0006505)2.61072924
135energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61066908
136ATP synthesis coupled proton transport (GO:0015986)2.61066908
137dendrite morphogenesis (GO:0048813)2.60150498
138fatty-acyl-CoA metabolic process (GO:0035337)2.60122909
139dendrite development (GO:0016358)2.59725205
140axon development (GO:0061564)2.59418623
141activated T cell proliferation (GO:0050798)2.58810629
142amyloid precursor protein metabolic process (GO:0042982)2.58717573
143regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.58695742
144negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58313692
145cell migration in hindbrain (GO:0021535)2.58121179
146regulation of feeding behavior (GO:0060259)2.57677509
147iron-sulfur cluster assembly (GO:0016226)2.56073898
148metallo-sulfur cluster assembly (GO:0031163)2.56073898
149neuron-neuron synaptic transmission (GO:0007270)2.55957810
150synaptic transmission, glutamatergic (GO:0035249)2.55470992
151synaptic transmission, cholinergic (GO:0007271)2.55323349
152negative regulation of mast cell activation (GO:0033004)2.55312301
153membrane tubulation (GO:0097320)2.55035635
154regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54972437
155positive regulation of synapse assembly (GO:0051965)2.54741413
156regulation of action potential (GO:0098900)2.54565621
157regulation of vesicle fusion (GO:0031338)2.54493545
158negative regulation of amino acid transport (GO:0051956)2.53448588
159response to catecholamine (GO:0071869)2.52735599
160response to monoamine (GO:0071867)2.52735599
161positive regulation of amine transport (GO:0051954)2.51376619
162pyrimidine-containing compound catabolic process (GO:0072529)2.50096964
163response to pheromone (GO:0019236)2.49978130
164cerebellar Purkinje cell differentiation (GO:0021702)2.49560956
165negative regulation of cation channel activity (GO:2001258)2.49100168
166positive regulation of protein homodimerization activity (GO:0090073)2.48708543
167glycosphingolipid biosynthetic process (GO:0006688)2.47255993
168negative regulation of synaptic transmission (GO:0050805)2.46952553
169actin nucleation (GO:0045010)2.46358903
170neuromuscular synaptic transmission (GO:0007274)2.46163375
171regulation of neurotransmitter transport (GO:0051588)2.46117288
172behavioral response to ethanol (GO:0048149)2.46052413
173positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46011830
174regulation of neurotransmitter levels (GO:0001505)2.45085210
175positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.44687542
176synaptic transmission, dopaminergic (GO:0001963)2.44522694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.99971378
2EZH2_22144423_ChIP-Seq_EOC_Human3.72361037
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80039340
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79093033
5TAF15_26573619_Chip-Seq_HEK293_Human2.77358208
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71603412
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67034724
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.49452824
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.40658010
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32943364
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32943364
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27678587
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27152084
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21030838
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19439737
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17596371
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16317957
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.15053800
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14260117
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12968526
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08931134
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.05405560
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04981654
24VDR_22108803_ChIP-Seq_LS180_Human2.04800008
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04273662
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03641677
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92609878
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91447096
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89392545
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.86610196
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.82012532
32REST_21632747_ChIP-Seq_MESCs_Mouse1.80270281
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73366980
34AR_21572438_ChIP-Seq_LNCaP_Human1.72913453
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72847560
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72701861
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71128359
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70210816
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69106979
40ER_23166858_ChIP-Seq_MCF-7_Human1.67976851
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66926478
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.62958928
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62820739
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60526458
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.59350945
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58861286
47DROSHA_22980978_ChIP-Seq_HELA_Human1.57127521
48P300_19829295_ChIP-Seq_ESCs_Human1.56530728
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56238584
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55955262
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54343519
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53074515
53FUS_26573619_Chip-Seq_HEK293_Human1.52838215
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.48501528
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.48427713
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.45218777
57RNF2_27304074_Chip-Seq_NSC_Mouse1.44537730
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.42900568
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.42160528
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39932868
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39626082
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36096102
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34813631
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34702152
65TP53_22573176_ChIP-Seq_HFKS_Human1.31012394
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30456243
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29173534
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26914410
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24165061
70SMAD4_21799915_ChIP-Seq_A2780_Human1.23477583
71* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21871987
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16908469
73VDR_23849224_ChIP-Seq_CD4+_Human1.15806199
74EWS_26573619_Chip-Seq_HEK293_Human1.15631169
75STAT3_23295773_ChIP-Seq_U87_Human1.14165781
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12813009
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11417749
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10396422
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08781536
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07395948
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07299184
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.06946518
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06550370
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06263064
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.06047942
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.05065685
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04255754
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.03749269
89MYC_18940864_ChIP-ChIP_HL60_Human1.03277757
90TCF4_23295773_ChIP-Seq_U87_Human1.02696545
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02432113
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.01908250
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.01851576
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.01825568
95SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01324288
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.01110519
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01053893
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00627449
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00222394
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00185000
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99100739
102SOX9_26525672_Chip-Seq_HEART_Mouse0.99010625
103RUNX2_22187159_ChIP-Seq_PCA_Human0.98857468
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98681949
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98385112
106CBP_20019798_ChIP-Seq_JUKART_Human0.98385112
107RING1B_27294783_Chip-Seq_ESCs_Mouse0.98335302
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98249350
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.98232621
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.97507395
111JUN_21703547_ChIP-Seq_K562_Human0.97191404
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96618829
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96438829
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96004657
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95018009
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.94868748
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94421463
118AHR_22903824_ChIP-Seq_MCF-7_Human0.93603187
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93452262
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93378195
121JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93361179
122ZNF274_21170338_ChIP-Seq_K562_Hela0.93249931
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92568854
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92463258
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92463258
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91881982
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91082520
128CIITA_25753668_ChIP-Seq_RAJI_Human0.91002262
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90842196
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.90817355
131P300_18555785_Chip-Seq_ESCs_Mouse0.90081593
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90076006
133AR_25329375_ChIP-Seq_VCAP_Human0.89844922
134IRF1_19129219_ChIP-ChIP_H3396_Human0.89467974
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89374260
136IGF1R_20145208_ChIP-Seq_DFB_Human0.88471333
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87225383
138IRF8_21731497_ChIP-ChIP_J774_Mouse0.86910753
139BP1_19119308_ChIP-ChIP_Hs578T_Human0.84582957
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84524708
141REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83055616
142FOXP3_21729870_ChIP-Seq_TREG_Human0.80464432
143* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80458753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.08311309
2MP0000920_abnormal_myelination4.19132728
3MP0004270_analgesia3.69746510
4MP0004859_abnormal_synaptic_plasticity3.30937909
5MP0001529_abnormal_vocalization2.98146010
6MP0002272_abnormal_nervous_system2.73637908
7MP0002064_seizures2.62797586
8MP0001486_abnormal_startle_reflex2.58738553
9MP0001905_abnormal_dopamine_level2.57337936
10MP0000778_abnormal_nervous_system2.55910403
11MP0003635_abnormal_synaptic_transmissio2.54208025
12MP0009745_abnormal_behavioral_response2.36452230
13MP0004742_abnormal_vestibular_system2.35915086
14MP0002638_abnormal_pupillary_reflex2.35602655
15MP0003950_abnormal_plasma_membrane2.32357892
16MP0009046_muscle_twitch2.32258273
17MP0003329_amyloid_beta_deposits2.26133593
18MP0002734_abnormal_mechanical_nocicepti2.23724713
19MP0004885_abnormal_endolymph2.22492418
20MP0003690_abnormal_glial_cell2.20343525
21MP0005171_absent_coat_pigmentation2.19842344
22MP0004142_abnormal_muscle_tone2.10132981
23MP0003136_yellow_coat_color2.10113479
24MP0001485_abnormal_pinna_reflex2.05495708
25MP0002572_abnormal_emotion/affect_behav2.05118193
26MP0005423_abnormal_somatic_nervous2.03502961
27MP0002063_abnormal_learning/memory/cond2.03131384
28MP0001968_abnormal_touch/_nociception1.94321493
29MP0003634_abnormal_glial_cell1.90652018
30MP0001440_abnormal_grooming_behavior1.90617641
31MP0005409_darkened_coat_color1.87589633
32MP0005671_abnormal_response_to1.81755016
33MP0002735_abnormal_chemical_nociception1.77277451
34MP0005499_abnormal_olfactory_system1.69870419
35MP0005394_taste/olfaction_phenotype1.69870419
36MP0002229_neurodegeneration1.69521955
37MP0002067_abnormal_sensory_capabilities1.63303026
38MP0002882_abnormal_neuron_morphology1.59383958
39MP0002736_abnormal_nociception_after1.59368876
40MP0000955_abnormal_spinal_cord1.58487882
41MP0001970_abnormal_pain_threshold1.56507492
42MP0004924_abnormal_behavior1.53175380
43MP0005386_behavior/neurological_phenoty1.53175380
44MP0003632_abnormal_nervous_system1.52738250
45MP0002733_abnormal_thermal_nociception1.49623643
46MP0000462_abnormal_digestive_system1.48065953
47MP0005451_abnormal_body_composition1.41520343
48MP0002066_abnormal_motor_capabilities/c1.40324813
49MP0005410_abnormal_fertilization1.38999270
50MP0002184_abnormal_innervation1.38010955
51MP0005551_abnormal_eye_electrophysiolog1.36028348
52MP0008877_abnormal_DNA_methylation1.34541544
53MP0006276_abnormal_autonomic_nervous1.33787707
54MP0003121_genomic_imprinting1.32060902
55MP0001963_abnormal_hearing_physiology1.31550482
56MP0002752_abnormal_somatic_nervous1.29673916
57MP0008569_lethality_at_weaning1.27081455
58MP0005084_abnormal_gallbladder_morpholo1.26708725
59MP0003938_abnormal_ear_development1.26165702
60MP0001986_abnormal_taste_sensitivity1.25998353
61MP0003303_peritoneal_inflammation1.25753720
62MP0004134_abnormal_chest_morphology1.24203169
63MP0006035_abnormal_mitochondrial_morpho1.21395607
64MP0002653_abnormal_ependyma_morphology1.20337416
65MP0010386_abnormal_urinary_bladder1.20174564
66MP0001984_abnormal_olfaction1.16903248
67MP0008789_abnormal_olfactory_epithelium1.15917548
68MP0003631_nervous_system_phenotype1.14637435
69MP0002557_abnormal_social/conspecific_i1.10161943
70MP0002152_abnormal_brain_morphology1.06699510
71MP0003787_abnormal_imprinting1.02922447
72MP0000026_abnormal_inner_ear1.01553365
73MP0001501_abnormal_sleep_pattern1.00456097
74MP0000604_amyloidosis0.99268360
75MP0004145_abnormal_muscle_electrophysio0.98596325
76MP0004811_abnormal_neuron_physiology0.97436470
77MP0008872_abnormal_physiological_respon0.96348615
78MP0005535_abnormal_body_temperature0.94068161
79MP0003633_abnormal_nervous_system0.92034147
80MP0005195_abnormal_posterior_eye0.91561639
81MP0004147_increased_porphyrin_level0.89940117
82MP0004381_abnormal_hair_follicle0.88956445
83MP0004043_abnormal_pH_regulation0.87442543
84MP0008874_decreased_physiological_sensi0.86693275
85MP0001790_abnormal_immune_system0.85840006
86MP0005387_immune_system_phenotype0.85840006
87MP0005623_abnormal_meninges_morphology0.85644934
88MP0003724_increased_susceptibility_to0.85558345
89MP0000631_abnormal_neuroendocrine_gland0.84864173
90MP0009764_decreased_sensitivity_to0.84323838
91MP0003122_maternal_imprinting0.83199702
92MP0002069_abnormal_eating/drinking_beha0.82761255
93MP0005645_abnormal_hypothalamus_physiol0.82483190
94MP0001835_abnormal_antigen_presentation0.81655684
95MP0001299_abnormal_eye_distance/0.81371104
96MP0002822_catalepsy0.80934698
97MP0002277_abnormal_respiratory_mucosa0.80809842
98MP0005000_abnormal_immune_tolerance0.80278605
99MP0002148_abnormal_hypersensitivity_rea0.79534834
100MP0001188_hyperpigmentation0.79498603
101MP0002102_abnormal_ear_morphology0.78772675
102MP0001502_abnormal_circadian_rhythm0.78353610
103MP0000566_synostosis0.77788256
104MP0010678_abnormal_skin_adnexa0.77350563
105MP0005464_abnormal_platelet_physiology0.76261766
106MP0005646_abnormal_pituitary_gland0.75601606
107MP0002938_white_spotting0.75410850
108MP0001800_abnormal_humoral_immune0.74900188
109MP0006072_abnormal_retinal_apoptosis0.72907958
110MP0000383_abnormal_hair_follicle0.72902138
111MP0008004_abnormal_stomach_pH0.72860370
112MP0001661_extended_life_span0.72257963
113MP0002751_abnormal_autonomic_nervous0.71970780
114MP0003861_abnormal_nervous_system0.71150128
115MP0009785_altered_susceptibility_to0.70268130
116MP0001346_abnormal_lacrimal_gland0.70089445
117MP0001177_atelectasis0.70065054
118MP0000747_muscle_weakness0.69203073
119MP0003137_abnormal_impulse_conducting0.68650985
120MP0005253_abnormal_eye_physiology0.68532786
121MP0004133_heterotaxia0.68299732
122MP0008260_abnormal_autophagy0.68170746
123MP0009765_abnormal_xenobiotic_induced0.68130081
124MP0000372_irregular_coat_pigmentation0.67508270
125MP0003195_calcinosis0.66456236
126MP0003937_abnormal_limbs/digits/tail_de0.66208376
127MP0000569_abnormal_digit_pigmentation0.66046699
128MP0005167_abnormal_blood-brain_barrier0.65795647
129MP0000647_abnormal_sebaceous_gland0.65599620
130MP0002909_abnormal_adrenal_gland0.65388071
131MP0001764_abnormal_homeostasis0.64094960
132MP0008995_early_reproductive_senescence0.63620748
133MP0002723_abnormal_immune_serum0.63494793
134MP0002090_abnormal_vision0.62572404
135MP0006036_abnormal_mitochondrial_physio0.62212326
136MP0000465_gastrointestinal_hemorrhage0.61893033
137MP0003806_abnormal_nucleotide_metabolis0.61646326
138MP0001348_abnormal_lacrimal_gland0.61467214

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.78320634
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.78320634
3Sensory axonal neuropathy (HP:0003390)5.60830269
4Neurofibrillary tangles (HP:0002185)5.23944944
5Abnormality of the corticospinal tract (HP:0002492)4.66591737
6Polyphagia (HP:0002591)4.29802192
7Parakeratosis (HP:0001036)4.07902879
8Abnormality of glycolysis (HP:0004366)4.05217936
9Increased serum pyruvate (HP:0003542)4.05217936
10Febrile seizures (HP:0002373)4.02970837
11Cerebral inclusion bodies (HP:0100314)3.94602583
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.91508319
13Myokymia (HP:0002411)3.83771543
14Peripheral hypomyelination (HP:0007182)3.67087929
15Spastic gait (HP:0002064)3.52850609
16Focal motor seizures (HP:0011153)3.52320831
17Supranuclear gaze palsy (HP:0000605)3.50283555
18Cerebral hypomyelination (HP:0006808)3.44996977
19Akinesia (HP:0002304)3.36116627
20Atonic seizures (HP:0010819)3.30866177
21Failure to thrive in infancy (HP:0001531)3.29649829
22Dysmetria (HP:0001310)3.06057121
23Impaired vibration sensation in the lower limbs (HP:0002166)3.05093660
24Epileptic encephalopathy (HP:0200134)3.03235115
25Leukodystrophy (HP:0002415)3.00174405
26Intention tremor (HP:0002080)2.98565008
27Insidious onset (HP:0003587)2.92850267
28Termporal pattern (HP:0011008)2.92850267
29Mutism (HP:0002300)2.90379208
30Hyperventilation (HP:0002883)2.89890295
31Urinary urgency (HP:0000012)2.87366146
32Alacrima (HP:0000522)2.81177812
33Onion bulb formation (HP:0003383)2.77928712
34Lissencephaly (HP:0001339)2.76825550
35Thickened helices (HP:0000391)2.72868402
36Congenital ichthyosiform erythroderma (HP:0007431)2.71868354
37Abnormal eating behavior (HP:0100738)2.70033345
38Abnormal auditory evoked potentials (HP:0006958)2.63227928
39Abnormality of the labia minora (HP:0012880)2.60760084
40Agitation (HP:0000713)2.59195452
41Retinal dysplasia (HP:0007973)2.59160663
42Acute necrotizing encephalopathy (HP:0006965)2.58042690
43Scanning speech (HP:0002168)2.56133343
44Generalized tonic-clonic seizures (HP:0002069)2.56082430
45Pheochromocytoma (HP:0002666)2.55354063
46Amyotrophic lateral sclerosis (HP:0007354)2.52865684
47Hepatic necrosis (HP:0002605)2.48313288
48Hypoplastic pelvis (HP:0008839)2.46082131
49Elevated erythrocyte sedimentation rate (HP:0003565)2.41304820
50Focal seizures (HP:0007359)2.41145714
51Renal Fanconi syndrome (HP:0001994)2.39730741
52Absent septum pellucidum (HP:0001331)2.37235158
53Hyperglycinemia (HP:0002154)2.32392769
54Ankle clonus (HP:0011448)2.29080616
55Vaginal atresia (HP:0000148)2.27298345
56Gait imbalance (HP:0002141)2.26113331
57Broad-based gait (HP:0002136)2.24604124
58Hypsarrhythmia (HP:0002521)2.23961783
59Neuroendocrine neoplasm (HP:0100634)2.22675797
60Slow saccadic eye movements (HP:0000514)2.22332458
61Epileptiform EEG discharges (HP:0011182)2.21303363
62Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20998329
63Hypoplasia of the brainstem (HP:0002365)2.20998329
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19865957
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19865957
66EEG with generalized epileptiform discharges (HP:0011198)2.19788287
67Decreased lacrimation (HP:0000633)2.18944947
68Amblyopia (HP:0000646)2.18207003
69Genital tract atresia (HP:0001827)2.17025657
70Partial agenesis of the corpus callosum (HP:0001338)2.16664557
71Spastic paraparesis (HP:0002313)2.16536998
72Mitochondrial inheritance (HP:0001427)2.15354962
73Autoamputation (HP:0001218)2.15238407
74Progressive macrocephaly (HP:0004481)2.11988136
75Cerebral hemorrhage (HP:0001342)2.11794398
76Poor suck (HP:0002033)2.11339289
77Urinary bladder sphincter dysfunction (HP:0002839)2.10984021
78Abnormality of the septum pellucidum (HP:0007375)2.10811084
79Abnormal mitochondria in muscle tissue (HP:0008316)2.07809927
80Spastic tetraplegia (HP:0002510)2.06551216
81Anteriorly placed anus (HP:0001545)2.06471876
82Medial flaring of the eyebrow (HP:0010747)2.06424050
83Diplopia (HP:0000651)2.05878507
84Abnormality of binocular vision (HP:0011514)2.05878507
85Stridor (HP:0010307)2.05230624
86Atrophy/Degeneration involving motor neurons (HP:0007373)2.05054006
87Dialeptic seizures (HP:0011146)2.04305930
88Anomalous pulmonary venous return (HP:0010772)2.04217520
89Acute encephalopathy (HP:0006846)2.03885956
90Esotropia (HP:0000565)2.03691692
91Lipid accumulation in hepatocytes (HP:0006561)2.03158380
92Drooling (HP:0002307)2.02738563
93Increased intramyocellular lipid droplets (HP:0012240)2.02424196
94Premature skin wrinkling (HP:0100678)2.02245623
953-Methylglutaconic aciduria (HP:0003535)2.02137589
96Hypomagnesemia (HP:0002917)2.02007793
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99885523
98Cortical dysplasia (HP:0002539)1.99857258
99Pachygyria (HP:0001302)1.99352555
100Stomatitis (HP:0010280)1.98620344
101Split foot (HP:0001839)1.97587817
102Excessive salivation (HP:0003781)1.97564085
103Lower limb muscle weakness (HP:0007340)1.96687688
104Status epilepticus (HP:0002133)1.95803539
105Generalized myoclonic seizures (HP:0002123)1.94857752
106Emotional lability (HP:0000712)1.94018159
107Methylmalonic acidemia (HP:0002912)1.93730608
108Increased circulating renin level (HP:0000848)1.93170832
109Optic disc pallor (HP:0000543)1.91432025
110Clumsiness (HP:0002312)1.91117838
111Poor speech (HP:0002465)1.90358551
112Congenital primary aphakia (HP:0007707)1.90283061
113Gaze-evoked nystagmus (HP:0000640)1.88612285
114True hermaphroditism (HP:0010459)1.88546825
115Diminished movement (HP:0002374)1.88458195
116Generalized aminoaciduria (HP:0002909)1.87853265
117Pancreatic cysts (HP:0001737)1.86893621
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86622000
119CNS hypomyelination (HP:0003429)1.86376389
120Molar tooth sign on MRI (HP:0002419)1.85197224
121Abnormality of midbrain morphology (HP:0002418)1.85197224
122Septo-optic dysplasia (HP:0100842)1.83574951
123Cupped ear (HP:0000378)1.83261734
124Delusions (HP:0000746)1.82797082
125Action tremor (HP:0002345)1.81787190
126Hepatocellular necrosis (HP:0001404)1.81379218
127Absence seizures (HP:0002121)1.81293910
128Abnormal hair whorl (HP:0010721)1.80706285
129Increased hepatocellular lipid droplets (HP:0006565)1.80481434
130Hemiparesis (HP:0001269)1.80267130
131Morphological abnormality of the pyramidal tract (HP:0002062)1.79791188
132Progressive cerebellar ataxia (HP:0002073)1.79690284
133Megalencephaly (HP:0001355)1.79235470
134Nephrogenic diabetes insipidus (HP:0009806)1.77961907
135Methylmalonic aciduria (HP:0012120)1.77708669
136Morphological abnormality of the inner ear (HP:0011390)1.77279693
137Inability to walk (HP:0002540)1.75908296
138Acute hepatic failure (HP:0006554)1.74335466
139Bowel incontinence (HP:0002607)1.72811514
140Infantile muscular hypotonia (HP:0008947)1.71808965
141Coronal craniosynostosis (HP:0004440)1.70885200
142Increased serum lactate (HP:0002151)1.70291683
143Progressive inability to walk (HP:0002505)1.70165157
144Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69944051
145Adrenal hypoplasia (HP:0000835)1.69559976
146Progressive microcephaly (HP:0000253)1.69037280
147Abnormality of the pulmonary veins (HP:0011718)1.68874219
148Specific learning disability (HP:0001328)1.67855201
149Widely spaced teeth (HP:0000687)1.67687046
150Erythroderma (HP:0001019)1.67628906
151White forelock (HP:0002211)1.67424333
152Absent speech (HP:0001344)1.66883337
153Lactic acidosis (HP:0003128)1.66503202
154Exertional dyspnea (HP:0002875)1.66055465
155Dysdiadochokinesis (HP:0002075)1.65701298
156Increased CSF lactate (HP:0002490)1.65130675
157Limb dystonia (HP:0002451)1.64206287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.18325464
2OXSR14.24057583
3BCR3.20947193
4CDK193.09471656
5TNIK3.02536846
6CASK3.00935986
7PRPF4B2.63807407
8BCKDK2.50502506
9PKN12.29553075
10MAP4K22.27135172
11MARK12.22780828
12EPHA42.21398781
13EPHB12.21324041
14PINK12.19099730
15UHMK12.13435505
16WNK42.00605514
17SIK22.00538977
18MAP3K111.92926716
19CSNK1G31.86554422
20LIMK11.83627547
21TAOK31.78781793
22FGFR21.70404010
23CSNK1A1L1.69396837
24CSNK1G21.57007095
25CAMK2B1.52875236
26NEK61.51632776
27MAP3K121.51617951
28NTRK11.48495680
29MET1.46042939
30WNK11.44635959
31TYRO31.43212547
32MAPK131.43130695
33PNCK1.38283772
34DYRK21.37602409
35PAK61.37169204
36PBK1.35519193
37FGR1.34546896
38ROCK21.33934979
39TXK1.33779093
40CSNK1G11.32937908
41NTRK31.32777199
42ICK1.30153957
43TESK11.29569008
44TAOK11.28734093
45TRIM281.27559002
46VRK11.26555930
47BMPR1B1.18082257
48DAPK11.16237941
49MAPKAPK51.16105393
50CAMKK21.14100366
51CAMK2D1.13326048
52VRK21.10716819
53PIM21.08797473
54SGK4941.07901529
55SGK2231.07901529
56TAOK21.07508787
57CDK141.06953123
58DYRK31.06658873
59CDK51.05607636
60MST41.03280485
61TLK11.02917326
62MAP4K11.00725947
63SYK0.99963086
64MATK0.97785636
65MARK20.96031998
66CAMK2A0.95856975
67MAP3K40.95564847
68CDK180.93497065
69CAMKK10.93106151
70CDK150.92839918
71EPHA30.92123727
72NTRK20.91249320
73ARAF0.88317215
74TESK20.86740536
75SIK30.85983563
76NME10.85766138
77GRK50.85324385
78CAMK2G0.83689284
79CDK11A0.82578600
80PLK20.82033233
81KDR0.81045482
82CLK10.80621813
83MAP3K90.80534908
84MUSK0.79401809
85MINK10.79005239
86MAP3K50.78645632
87MAP2K70.78403448
88RPS6KA50.77326341
89FES0.76427888
90ADRBK20.75508728
91PAK30.75113027
92PRKCE0.70769009
93ERBB30.70057630
94PHKG20.67407957
95PHKG10.67407957
96GRK70.66799120
97DAPK20.66360031
98PRKCQ0.64496231
99RIPK40.64203501
100DAPK30.62436611
101SRPK10.61172429
102LYN0.60717520
103BTK0.60528469
104IRAK20.59741137
105KIT0.58839822
106DYRK1A0.58646529
107INSRR0.57065984
108FYN0.56152068
109KSR20.56135064
110PRKCG0.53485345
111PRKCZ0.53393400
112MAPK70.52297847
113ERBB40.50703474
114ITK0.49455275
115ZAK0.47893857
116PDPK10.47783157
117LCK0.47060851
118CCNB10.46699561
119BMPR20.43779191
120PTK2B0.43369828
121PRKG10.43104890
122WNK30.41593867
123NUAK10.40958689
124PRKD10.39425246
125STK160.38401504
126CSNK1D0.37662205
127STK110.37520448
128TEC0.37492810
129MAPK120.37015949
130CSNK1A10.36050287
131MAPKAPK30.35812663
132PRKCA0.35511351
133ADRBK10.35317951
134PRKACA0.35236710
135PRKACB0.34454928
136IRAK10.34243742
137MAP3K20.31393832
138KSR10.30384302
139MAP2K40.30049680
140PAK10.29254682
141ROCK10.27342385
142PRKCH0.25983666
143MAPK150.24853783
144GRK10.24569268
145EPHB20.24215582
146INSR0.23362546

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.91500944
2Steroid biosynthesis_Homo sapiens_hsa001003.89314925
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.52589611
4Fatty acid elongation_Homo sapiens_hsa000623.42709927
5Oxidative phosphorylation_Homo sapiens_hsa001903.08589259
6Ether lipid metabolism_Homo sapiens_hsa005652.38909154
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29361606
8Parkinsons disease_Homo sapiens_hsa050122.20943680
9Axon guidance_Homo sapiens_hsa043602.19976303
10Collecting duct acid secretion_Homo sapiens_hsa049662.08947083
11Alzheimers disease_Homo sapiens_hsa050102.07459470
12Nicotine addiction_Homo sapiens_hsa050332.03304913
13Synaptic vesicle cycle_Homo sapiens_hsa047211.89873994
14Glutamatergic synapse_Homo sapiens_hsa047241.86351933
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85610488
16GABAergic synapse_Homo sapiens_hsa047271.85357647
17Serotonergic synapse_Homo sapiens_hsa047261.80837656
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79360136
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64895994
20Morphine addiction_Homo sapiens_hsa050321.59853491
21Vibrio cholerae infection_Homo sapiens_hsa051101.57332393
22Primary immunodeficiency_Homo sapiens_hsa053401.57233900
23Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.55581959
24Sphingolipid metabolism_Homo sapiens_hsa006001.44228222
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42230726
26Long-term depression_Homo sapiens_hsa047301.42054983
27Circadian entrainment_Homo sapiens_hsa047131.41794687
28Allograft rejection_Homo sapiens_hsa053301.37086673
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.36412062
30Huntingtons disease_Homo sapiens_hsa050161.36355313
31Cardiac muscle contraction_Homo sapiens_hsa042601.33599389
32Type I diabetes mellitus_Homo sapiens_hsa049401.32696092
33Asthma_Homo sapiens_hsa053101.32476741
34Protein export_Homo sapiens_hsa030601.32257186
35Vitamin B6 metabolism_Homo sapiens_hsa007501.28938225
36Butanoate metabolism_Homo sapiens_hsa006501.23708315
37Sulfur metabolism_Homo sapiens_hsa009201.20588446
38Dopaminergic synapse_Homo sapiens_hsa047281.19490540
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18823392
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15991942
41Graft-versus-host disease_Homo sapiens_hsa053321.13105016
42Cholinergic synapse_Homo sapiens_hsa047251.12545842
43Salivary secretion_Homo sapiens_hsa049701.06012118
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05832427
45Phototransduction_Homo sapiens_hsa047441.05301226
46Linoleic acid metabolism_Homo sapiens_hsa005911.03611525
47Renal cell carcinoma_Homo sapiens_hsa052111.01655932
48Long-term potentiation_Homo sapiens_hsa047201.00734637
49Taste transduction_Homo sapiens_hsa047421.00398589
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99492854
51Rheumatoid arthritis_Homo sapiens_hsa053230.97651929
52Amphetamine addiction_Homo sapiens_hsa050310.92702022
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92032928
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91423963
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85553080
56Olfactory transduction_Homo sapiens_hsa047400.83947622
57RNA polymerase_Homo sapiens_hsa030200.82796771
58Cocaine addiction_Homo sapiens_hsa050300.79963127
59Renin secretion_Homo sapiens_hsa049240.78446196
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.77327508
61ErbB signaling pathway_Homo sapiens_hsa040120.76718619
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.75185966
63Hematopoietic cell lineage_Homo sapiens_hsa046400.74171456
64Tight junction_Homo sapiens_hsa045300.73545911
65Ras signaling pathway_Homo sapiens_hsa040140.73487133
66Gastric acid secretion_Homo sapiens_hsa049710.72741852
67Gap junction_Homo sapiens_hsa045400.72739654
68Phagosome_Homo sapiens_hsa041450.71514019
69Salmonella infection_Homo sapiens_hsa051320.70436136
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70426526
71Systemic lupus erythematosus_Homo sapiens_hsa053220.69185494
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.69064909
73Nitrogen metabolism_Homo sapiens_hsa009100.67098284
74Oxytocin signaling pathway_Homo sapiens_hsa049210.65275005
75Histidine metabolism_Homo sapiens_hsa003400.64964334
76Calcium signaling pathway_Homo sapiens_hsa040200.62122182
77Ovarian steroidogenesis_Homo sapiens_hsa049130.61905147
78Endocytosis_Homo sapiens_hsa041440.61700435
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61653390
80Viral myocarditis_Homo sapiens_hsa054160.61326833
81Arginine and proline metabolism_Homo sapiens_hsa003300.59858827
82Shigellosis_Homo sapiens_hsa051310.59495445
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58849247
84Peroxisome_Homo sapiens_hsa041460.56375062
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56369553
86Insulin secretion_Homo sapiens_hsa049110.56284263
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55806930
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53523086
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51217530
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48655810
91Basal transcription factors_Homo sapiens_hsa030220.48046656
92Regulation of autophagy_Homo sapiens_hsa041400.47214064
93GnRH signaling pathway_Homo sapiens_hsa049120.47163943
94Hedgehog signaling pathway_Homo sapiens_hsa043400.46861762
95cAMP signaling pathway_Homo sapiens_hsa040240.46683442
96Chemokine signaling pathway_Homo sapiens_hsa040620.46127096
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45995687
98Autoimmune thyroid disease_Homo sapiens_hsa053200.45548956
99Arachidonic acid metabolism_Homo sapiens_hsa005900.45029117
100Alcoholism_Homo sapiens_hsa050340.42851320
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.42850508
102Choline metabolism in cancer_Homo sapiens_hsa052310.41599391
103Oocyte meiosis_Homo sapiens_hsa041140.40905597
104Pancreatic secretion_Homo sapiens_hsa049720.40332816
105RNA degradation_Homo sapiens_hsa030180.39728551
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39028580
107Fatty acid metabolism_Homo sapiens_hsa012120.38317844
108Antigen processing and presentation_Homo sapiens_hsa046120.37937864
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36742728
110MAPK signaling pathway_Homo sapiens_hsa040100.36374850
111Melanogenesis_Homo sapiens_hsa049160.36138219
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36016583
113Tuberculosis_Homo sapiens_hsa051520.35893569
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35624507
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.34424998
116Metabolic pathways_Homo sapiens_hsa011000.34149767
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33189349
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32568745
119Dorso-ventral axis formation_Homo sapiens_hsa043200.31213858
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29902791
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29738807
122Base excision repair_Homo sapiens_hsa034100.29524462
123Epstein-Barr virus infection_Homo sapiens_hsa051690.27982384
124Glutathione metabolism_Homo sapiens_hsa004800.27848461
125T cell receptor signaling pathway_Homo sapiens_hsa046600.27062855
126Purine metabolism_Homo sapiens_hsa002300.26790493
127Wnt signaling pathway_Homo sapiens_hsa043100.26780000
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26765290
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26266786
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24191729
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22867811
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22552243
133Proteasome_Homo sapiens_hsa030500.22455587
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20547180
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19277595

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