RAB33B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.93970711
2central nervous system myelination (GO:0022010)7.93970711
3signal peptide processing (GO:0006465)5.14535602
4myelination (GO:0042552)4.34645739
5oligodendrocyte differentiation (GO:0048709)4.32033745
6regulation of hexokinase activity (GO:1903299)4.28517389
7regulation of glucokinase activity (GO:0033131)4.28517389
8axon ensheathment (GO:0008366)4.28306334
9ensheathment of neurons (GO:0007272)4.28306334
10long-chain fatty acid biosynthetic process (GO:0042759)4.20330780
11ER overload response (GO:0006983)4.18991997
12fatty acid elongation (GO:0030497)4.09606090
13negative regulation of neurotransmitter secretion (GO:0046929)4.00912470
14negative regulation of JUN kinase activity (GO:0043508)3.99375713
15respiratory chain complex IV assembly (GO:0008535)3.98160656
16response to redox state (GO:0051775)3.92716597
17negative regulation of neurotransmitter transport (GO:0051589)3.92643268
18lactate metabolic process (GO:0006089)3.91410019
19regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.89052937
20photoreceptor cell differentiation (GO:0046530)3.80773271
21eye photoreceptor cell differentiation (GO:0001754)3.80773271
22platelet dense granule organization (GO:0060155)3.80257790
23L-fucose catabolic process (GO:0042355)3.78149383
24fucose catabolic process (GO:0019317)3.78149383
25L-fucose metabolic process (GO:0042354)3.78149383
26cellular ketone body metabolic process (GO:0046950)3.74070967
27regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.69712966
28nucleotide transmembrane transport (GO:1901679)3.66980499
29cytochrome complex assembly (GO:0017004)3.65006802
30myelin maintenance (GO:0043217)3.63061995
31cerebral cortex radially oriented cell migration (GO:0021799)3.60698735
32keratinocyte development (GO:0003334)3.59910059
33positive regulation of protein autophosphorylation (GO:0031954)3.57792410
34protein K11-linked deubiquitination (GO:0035871)3.56957048
35presynaptic membrane assembly (GO:0097105)3.55577534
36water-soluble vitamin biosynthetic process (GO:0042364)3.49351650
37presynaptic membrane organization (GO:0097090)3.47101792
38ketone body metabolic process (GO:1902224)3.44059631
39response to pheromone (GO:0019236)3.41184803
40neurotransmitter uptake (GO:0001504)3.40060636
41indolalkylamine metabolic process (GO:0006586)3.39990390
42protein neddylation (GO:0045116)3.38462201
43dopamine biosynthetic process (GO:0042416)3.29842119
44inositol phosphate catabolic process (GO:0071545)3.29625304
45kidney morphogenesis (GO:0060993)3.25677523
46positive regulation of glycolytic process (GO:0045821)3.24335608
47indole-containing compound catabolic process (GO:0042436)3.22716305
48indolalkylamine catabolic process (GO:0046218)3.22716305
49tryptophan catabolic process (GO:0006569)3.22716305
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17076553
51tryptophan metabolic process (GO:0006568)3.16945360
52startle response (GO:0001964)3.16301096
53DNA deamination (GO:0045006)3.16131444
54cholesterol biosynthetic process (GO:0006695)3.15286393
55protein complex biogenesis (GO:0070271)3.15146870
56response to lipoprotein particle (GO:0055094)3.10171253
57axoneme assembly (GO:0035082)3.07956119
58DNA double-strand break processing (GO:0000729)3.07384208
59enteric nervous system development (GO:0048484)3.05742378
60negative regulation of protein localization to cell surface (GO:2000009)3.05685352
61extracellular fibril organization (GO:0043206)3.05140441
62regulation of type B pancreatic cell apoptotic process (GO:2000674)3.04050074
63negative regulation of protein oligomerization (GO:0032460)3.03402189
64S-adenosylmethionine metabolic process (GO:0046500)2.97002946
65inositol phosphate dephosphorylation (GO:0046855)2.96527036
66phosphorylated carbohydrate dephosphorylation (GO:0046838)2.96527036
67insulin secretion (GO:0030073)2.95168513
68prenylation (GO:0097354)2.94599224
69protein prenylation (GO:0018342)2.94599224
70positive regulation of mitochondrial fission (GO:0090141)2.92880310
71axon development (GO:0061564)2.91052159
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.90452201
73peptidyl-histidine modification (GO:0018202)2.89957201
74magnesium ion transport (GO:0015693)2.89112938
75Golgi to plasma membrane protein transport (GO:0043001)2.86545787
76mitochondrial respiratory chain complex assembly (GO:0033108)2.86361334
77positive regulation of oligodendrocyte differentiation (GO:0048714)2.86228544
78polyol catabolic process (GO:0046174)2.84697595
79L-amino acid import (GO:0043092)2.83518153
80detection of light stimulus involved in visual perception (GO:0050908)2.82114717
81detection of light stimulus involved in sensory perception (GO:0050962)2.82114717
82substantia nigra development (GO:0021762)2.81411103
83regulation of meiosis I (GO:0060631)2.81247615
84sterol biosynthetic process (GO:0016126)2.80756616
85amino acid import (GO:0043090)2.79545786
86GPI anchor biosynthetic process (GO:0006506)2.75749319
87dopamine transport (GO:0015872)2.75305857
88developmental pigmentation (GO:0048066)2.75065348
89isoprenoid biosynthetic process (GO:0008299)2.73985530
90regulation of cilium movement (GO:0003352)2.72634099
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71739075
92neuron cell-cell adhesion (GO:0007158)2.71074564
93nitric oxide mediated signal transduction (GO:0007263)2.70913602
94peripheral nervous system axon ensheathment (GO:0032292)2.70866983
95myelination in peripheral nervous system (GO:0022011)2.70866983
96proline transport (GO:0015824)2.70205693
97regulation of collateral sprouting (GO:0048670)2.69911142
98behavioral response to nicotine (GO:0035095)2.69870693
99mannosylation (GO:0097502)2.68750035
100zinc ion transport (GO:0006829)2.68650452
101protein localization to cilium (GO:0061512)2.68347300
102detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67471155
103prostate gland growth (GO:0060736)2.64525310
104regulation of protein glycosylation (GO:0060049)2.63811995
105pancreas development (GO:0031016)2.63652837
106neural tube formation (GO:0001841)2.63627959
107glycerophospholipid catabolic process (GO:0046475)2.63318214
108positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.62795985
109regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.62795985
110negative regulation of translation, ncRNA-mediated (GO:0040033)2.62339954
111regulation of translation, ncRNA-mediated (GO:0045974)2.62339954
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62339954
113regulation of protein autophosphorylation (GO:0031952)2.62089701
114anterograde synaptic vesicle transport (GO:0048490)2.62079219
115intraciliary transport (GO:0042073)2.61349027
116regulation of Rac protein signal transduction (GO:0035020)2.60981934
117cilium morphogenesis (GO:0060271)2.60609255
118retinal cone cell development (GO:0046549)2.59793444
119nucleotide transport (GO:0006862)2.58516657
120GPI anchor metabolic process (GO:0006505)2.58277481
121positive regulation of glycoprotein biosynthetic process (GO:0010560)2.58042902
122establishment of protein localization to Golgi (GO:0072600)2.57286684
123preassembly of GPI anchor in ER membrane (GO:0016254)2.53713987
124leukocyte migration involved in inflammatory response (GO:0002523)2.52766990
125apical protein localization (GO:0045176)2.52480119
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.51418903
127peptide hormone processing (GO:0016486)2.50844686
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.50528410
129NADH dehydrogenase complex assembly (GO:0010257)2.50528410
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50528410
131kynurenine metabolic process (GO:0070189)2.50451177
132protein maturation by protein folding (GO:0022417)2.50154759
133nonmotile primary cilium assembly (GO:0035058)2.49750834
134negative regulation of telomere maintenance (GO:0032205)2.49335954
135epithelial cilium movement (GO:0003351)2.48973898
136positive regulation of meiosis (GO:0045836)2.48538099
137cullin deneddylation (GO:0010388)2.46621385
138protein targeting to Golgi (GO:0000042)2.46601136
139adaptation of signaling pathway (GO:0023058)2.46187405
140substrate-independent telencephalic tangential migration (GO:0021826)2.45835761
141substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.45835761
142regulation of acrosome reaction (GO:0060046)2.45099471
143positive regulation of mRNA catabolic process (GO:0061014)2.44709870
144regulation of neurotransmitter uptake (GO:0051580)2.44308057
145nucleoside diphosphate catabolic process (GO:0009134)2.43141820
146peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.43083609
147adenosine metabolic process (GO:0046085)2.42578909
148aromatic amino acid family catabolic process (GO:0009074)2.42109433
149positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.41768594
150regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.41768594
151negative regulation of mast cell activation (GO:0033004)2.41137287
152replication fork processing (GO:0031297)2.40964821
153negative regulation of glycogen biosynthetic process (GO:0045719)2.40449175
154regulation of timing of cell differentiation (GO:0048505)2.40300397
155asymmetric protein localization (GO:0008105)2.39548148
156protein localization to Golgi apparatus (GO:0034067)2.39495644
157glycosphingolipid catabolic process (GO:0046479)2.39140545
158dentate gyrus development (GO:0021542)2.37148372
159exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36805357
160negative regulation of acute inflammatory response (GO:0002674)2.35991501
161negative regulation of glucose import (GO:0046325)2.35873319
162astrocyte development (GO:0014002)2.33705205
163Sertoli cell development (GO:0060009)2.32287869
164interleukin-6-mediated signaling pathway (GO:0070102)2.31949625
165endocrine pancreas development (GO:0031018)2.31603196
166spinal cord motor neuron differentiation (GO:0021522)2.31336653
167peripheral nervous system development (GO:0007422)2.31055585
168C-terminal protein lipidation (GO:0006501)2.28716006
169protein palmitoylation (GO:0018345)2.28620737
170regulation of dopamine metabolic process (GO:0042053)2.28364382
171regulation of catecholamine metabolic process (GO:0042069)2.28364382
172cranial nerve development (GO:0021545)2.26811348
173negative regulation of synaptic transmission, GABAergic (GO:0032229)2.26789918
174glycolipid catabolic process (GO:0019377)2.26400651
175sequestering of metal ion (GO:0051238)2.25187228
176glial cell differentiation (GO:0010001)2.25114418
177cellular response to hepatocyte growth factor stimulus (GO:0035729)2.24672770
178response to hepatocyte growth factor (GO:0035728)2.24672770
179fibril organization (GO:0097435)2.24130304
180establishment of mitochondrion localization (GO:0051654)2.23328197
181glial cell development (GO:0021782)2.21316217
182natural killer cell activation involved in immune response (GO:0002323)2.19781265
183positive regulation of amino acid transport (GO:0051957)2.18462600
184positive regulation of glial cell differentiation (GO:0045687)2.17974193
185glycosylceramide metabolic process (GO:0006677)2.17358528
186intracellular pH reduction (GO:0051452)2.16553561
187regulation of cytokine production involved in inflammatory response (GO:1900015)2.16003111
188dermatan sulfate biosynthetic process (GO:0030208)2.15433350
189positive regulation of cell fate commitment (GO:0010455)2.15261379
190adult locomotory behavior (GO:0008344)2.14735856
191neural nucleus development (GO:0048857)2.13597110
192limb bud formation (GO:0060174)2.13588372
193vesicle fusion (GO:0006906)2.13302802
194nucleotide-sugar biosynthetic process (GO:0009226)2.12940351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.41819619
2ZNF274_21170338_ChIP-Seq_K562_Hela3.12756564
3VDR_22108803_ChIP-Seq_LS180_Human3.05293196
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89715168
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79389363
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57149800
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.50660920
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45891596
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.31815451
10OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.14777254
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09824451
12FUS_26573619_Chip-Seq_HEK293_Human2.04592163
13AR_21572438_ChIP-Seq_LNCaP_Human1.98847838
14P300_19829295_ChIP-Seq_ESCs_Human1.96870366
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93420914
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91817630
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91653432
18IGF1R_20145208_ChIP-Seq_DFB_Human1.88633296
19ER_23166858_ChIP-Seq_MCF-7_Human1.87761337
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.81017713
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80797055
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77829005
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73971785
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.73330750
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72754821
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.69081797
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68126175
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65290748
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.64806269
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.64698766
31* BCAT_22108803_ChIP-Seq_LS180_Human1.61463473
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.60607576
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60121809
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59937821
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58689506
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.57327972
37TAF15_26573619_Chip-Seq_HEK293_Human1.57166408
38ELK1_19687146_ChIP-ChIP_HELA_Human1.56758180
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55860449
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.54707848
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52180295
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50870666
43EZH2_22144423_ChIP-Seq_EOC_Human1.50129594
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50128995
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49811473
46SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49088232
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49035794
48AR_25329375_ChIP-Seq_VCAP_Human1.48168153
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47692157
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47074028
51CBP_20019798_ChIP-Seq_JUKART_Human1.47074028
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45057814
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.44191365
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.42962803
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42463775
56TP53_22573176_ChIP-Seq_HFKS_Human1.42161160
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.41447419
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40991392
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40410849
60EWS_26573619_Chip-Seq_HEK293_Human1.40110697
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.40065646
62* SOX2_19829295_ChIP-Seq_ESCs_Human1.39915023
63* NANOG_19829295_ChIP-Seq_ESCs_Human1.39915023
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.39005934
65CDX2_22108803_ChIP-Seq_LS180_Human1.38075706
66P53_22387025_ChIP-Seq_ESCs_Mouse1.37196717
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37084804
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36963534
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35849214
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35188495
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.34731180
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34105208
73TCF4_22108803_ChIP-Seq_LS180_Human1.33473755
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33457326
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.33403607
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33396755
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33347771
78STAT3_23295773_ChIP-Seq_U87_Human1.32858053
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.32674004
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32160726
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31985634
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.31702354
83P300_18555785_Chip-Seq_ESCs_Mouse1.30783288
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.30475192
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30447464
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30447464
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30333550
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30201346
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29988047
90TCF4_23295773_ChIP-Seq_U87_Human1.29571178
91RNF2_27304074_Chip-Seq_NSC_Mouse1.28538064
92NMYC_18555785_Chip-Seq_ESCs_Mouse1.27657681
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26642805
94* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25965856
95EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25492093
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25492093
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24297341
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24235863
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.24139730
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23867455
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.22515417
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22403192
103VDR_23849224_ChIP-Seq_CD4+_Human1.22332151
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21996342
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.21750209
106SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21355765
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.21027641
108JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20283006
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19598640
110TP53_18474530_ChIP-ChIP_U2OS_Human1.19224167
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16721823
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16505044
113* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16504207
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16416094
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.16084520
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16084520
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.14626656
118RNF2_27304074_Chip-Seq_ESCs_Mouse1.13896549
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13086835
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12484741
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12256551
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11188247
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10721749
124RUNX2_22187159_ChIP-Seq_PCA_Human1.10649525
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10557082
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09845863
127MYC_18940864_ChIP-ChIP_HL60_Human1.09705454
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.09557319
129EZH2_27294783_Chip-Seq_ESCs_Mouse1.09478219
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09281723
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.07909231
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07825092
133KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07514733
134* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07297965
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07074228
136NFE2_27457419_Chip-Seq_LIVER_Mouse1.06759198
137OCT4_18555785_Chip-Seq_ESCs_Mouse1.06755246
138PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06295698
139SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05233627
140NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05127788
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04930045
142AR_20517297_ChIP-Seq_VCAP_Human1.03369758
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02026472
144IRF1_19129219_ChIP-ChIP_H3396_Human0.98082933
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97230451
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96824127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation3.86153807
2MP0000569_abnormal_digit_pigmentation3.54388803
3MP0000920_abnormal_myelination3.45913024
4MP0002837_dystrophic_cardiac_calcinosis2.74049738
5MP0002102_abnormal_ear_morphology2.69945105
6MP0005379_endocrine/exocrine_gland_phen2.64557467
7MP0001905_abnormal_dopamine_level2.53995623
8MP0004270_analgesia2.45736062
9MP0003136_yellow_coat_color2.39776524
10MP0008438_abnormal_cutaneous_collagen2.36074169
11MP0001529_abnormal_vocalization2.27785028
12MP0002254_reproductive_system_inflammat2.25004944
13MP0001986_abnormal_taste_sensitivity2.22669998
14MP0003880_abnormal_central_pattern2.22262268
15MP0004043_abnormal_pH_regulation2.21203188
16MP0005645_abnormal_hypothalamus_physiol2.16406463
17MP0005646_abnormal_pituitary_gland2.15955523
18MP0003283_abnormal_digestive_organ2.10463956
19MP0003690_abnormal_glial_cell2.06291014
20MP0002909_abnormal_adrenal_gland1.98835995
21MP0002734_abnormal_mechanical_nocicepti1.96651019
22MP0005503_abnormal_tendon_morphology1.95016289
23MP0000427_abnormal_hair_cycle1.94328028
24MP0002938_white_spotting1.91669751
25MP0002638_abnormal_pupillary_reflex1.86726265
26MP0010386_abnormal_urinary_bladder1.86502774
27MP0001486_abnormal_startle_reflex1.82824026
28MP0002272_abnormal_nervous_system1.82476327
29MP0003634_abnormal_glial_cell1.78971514
30MP0000778_abnormal_nervous_system1.76913540
31MP0004742_abnormal_vestibular_system1.76786965
32MP0006054_spinal_hemorrhage1.75687566
33MP0003183_abnormal_peptide_metabolism1.74463130
34MP0005174_abnormal_tail_pigmentation1.67323127
35MP0003950_abnormal_plasma_membrane1.65321347
36MP0003121_genomic_imprinting1.64712940
37MP0005409_darkened_coat_color1.64414545
38MP0010234_abnormal_vibrissa_follicle1.61804019
39MP0002877_abnormal_melanocyte_morpholog1.59176830
40MP0000516_abnormal_urinary_system1.56509790
41MP0005367_renal/urinary_system_phenotyp1.56509790
42MP0004142_abnormal_muscle_tone1.54064220
43MP0000566_synostosis1.51199515
44MP0006292_abnormal_olfactory_placode1.47370347
45MP0005084_abnormal_gallbladder_morpholo1.47242138
46MP0008057_abnormal_DNA_replication1.46225885
47MP0003329_amyloid_beta_deposits1.45990470
48MP0005075_abnormal_melanosome_morpholog1.44830268
49MP0002928_abnormal_bile_duct1.44812671
50MP0010678_abnormal_skin_adnexa1.44666863
51MP0001299_abnormal_eye_distance/1.44272402
52MP0002064_seizures1.41886452
53MP0006276_abnormal_autonomic_nervous1.41505081
54MP0005220_abnormal_exocrine_pancreas1.39529543
55MP0000372_irregular_coat_pigmentation1.38779625
56MP0005423_abnormal_somatic_nervous1.38747607
57MP0008872_abnormal_physiological_respon1.38029110
58MP0000462_abnormal_digestive_system1.37980663
59MP0005408_hypopigmentation1.37298595
60MP0003122_maternal_imprinting1.37108762
61MP0000013_abnormal_adipose_tissue1.36983495
62MP0003195_calcinosis1.36730566
63MP0008875_abnormal_xenobiotic_pharmacok1.33395555
64MP0001984_abnormal_olfaction1.30933832
65MP0001188_hyperpigmentation1.29780923
66MP0003635_abnormal_synaptic_transmissio1.29049862
67MP0006072_abnormal_retinal_apoptosis1.28855010
68MP0002090_abnormal_vision1.28695114
69MP0005332_abnormal_amino_acid1.27365566
70MP0002277_abnormal_respiratory_mucosa1.26355895
71MP0005360_urolithiasis1.26231848
72MP0003724_increased_susceptibility_to1.25836051
73MP0002572_abnormal_emotion/affect_behav1.24824004
74MP0001542_abnormal_bone_strength1.24124748
75MP0003252_abnormal_bile_duct1.22072521
76MP0001485_abnormal_pinna_reflex1.21677367
77MP0001502_abnormal_circadian_rhythm1.21150741
78MP0000631_abnormal_neuroendocrine_gland1.19727043
79MP0002735_abnormal_chemical_nociception1.18812214
80MP0000955_abnormal_spinal_cord1.18400876
81MP0004885_abnormal_endolymph1.17283010
82MP0005508_abnormal_skeleton_morphology1.16053046
83MP0005253_abnormal_eye_physiology1.15710037
84MP0002138_abnormal_hepatobiliary_system1.15504088
85MP0009780_abnormal_chondrocyte_physiolo1.14268785
86MP0009745_abnormal_behavioral_response1.12446250
87MP0001970_abnormal_pain_threshold1.11972683
88MP0000647_abnormal_sebaceous_gland1.11949287
89MP0010329_abnormal_lipoprotein_level1.11794866
90MP0002751_abnormal_autonomic_nervous1.11554868
91MP0009046_muscle_twitch1.11001003
92MP0008877_abnormal_DNA_methylation1.09777125
93MP0000681_abnormal_thyroid_gland1.09561210
94MP0000613_abnormal_salivary_gland1.09177900
95MP0003786_premature_aging1.08131220
96MP0001764_abnormal_homeostasis1.08077536
97MP0003632_abnormal_nervous_system1.07860075
98MP0003011_delayed_dark_adaptation1.06056423
99MP0000015_abnormal_ear_pigmentation1.06037627
100MP0009250_abnormal_appendicular_skeleto1.04690931
101MP0002067_abnormal_sensory_capabilities1.04598120
102MP0001968_abnormal_touch/_nociception1.04585988
103MP0008569_lethality_at_weaning1.03706792
104MP0001756_abnormal_urination1.03239984
105MP0004134_abnormal_chest_morphology1.02360883
106MP0002163_abnormal_gland_morphology1.02330598
107MP0004924_abnormal_behavior1.01947311
108MP0005386_behavior/neurological_phenoty1.01947311
109MP0002229_neurodegeneration1.01152373
110MP0004215_abnormal_myocardial_fiber1.00255314
111MP0002693_abnormal_pancreas_physiology0.99112203
112MP0001177_atelectasis0.98599840
113MP0001963_abnormal_hearing_physiology0.97652230
114MP0002882_abnormal_neuron_morphology0.95769076
115MP0000003_abnormal_adipose_tissue0.95212269
116MP0002733_abnormal_thermal_nociception0.94196637
117MP0008775_abnormal_heart_ventricle0.93167568
118MP0002009_preneoplasia0.93022979
119MP0008995_early_reproductive_senescence0.92921490
120MP0004133_heterotaxia0.92176029
121MP0008058_abnormal_DNA_repair0.91391468
122MP0002063_abnormal_learning/memory/cond0.90636200
123MP0008260_abnormal_autophagy0.90435883
124MP0002078_abnormal_glucose_homeostasis0.90409207
125MP0006036_abnormal_mitochondrial_physio0.90143998
126MP0003631_nervous_system_phenotype0.88745175
127MP0001324_abnormal_eye_pigmentation0.87653830
128MP0005365_abnormal_bile_salt0.86620943
129MP0004484_altered_response_of0.86497509
130MP0002876_abnormal_thyroid_physiology0.86216119
131MP0000538_abnormal_urinary_bladder0.86154475
132MP0003633_abnormal_nervous_system0.83249086
133MP0000383_abnormal_hair_follicle0.82556315
134MP0002166_altered_tumor_susceptibility0.81341757
135MP0006035_abnormal_mitochondrial_morpho0.81322221
136MP0005389_reproductive_system_phenotype0.79859302
137MP0005551_abnormal_eye_electrophysiolog0.79750467
138MP0003787_abnormal_imprinting0.79512759
139MP0001348_abnormal_lacrimal_gland0.78871398
140MP0002066_abnormal_motor_capabilities/c0.78777464
141MP0002752_abnormal_somatic_nervous0.77058797
142MP0001501_abnormal_sleep_pattern0.75954491
143MP0002557_abnormal_social/conspecific_i0.75706519
144MP0005187_abnormal_penis_morphology0.75598200
145MP0004019_abnormal_vitamin_homeostasis0.75501168
146MP0001944_abnormal_pancreas_morphology0.75474175
147MP0002184_abnormal_innervation0.75419523
148MP0000049_abnormal_middle_ear0.75354534
149MP0002736_abnormal_nociception_after0.74859454
150MP0003718_maternal_effect0.74800014
151MP0005410_abnormal_fertilization0.74798882
152MP0004085_abnormal_heartbeat0.73217496
153MP0005636_abnormal_mineral_homeostasis0.72926322
154MP0005310_abnormal_salivary_gland0.72498827
155MP0003279_aneurysm0.72377587
156MP0001661_extended_life_span0.71796737
157MP0003119_abnormal_digestive_system0.71072374
158MP0001919_abnormal_reproductive_system0.71061842

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.66188207
2Pancreatic cysts (HP:0001737)3.61040083
3Hypoglycemic coma (HP:0001325)3.36012918
4Hypoplasia of the fovea (HP:0007750)3.33933157
5Aplasia/Hypoplasia of the fovea (HP:0008060)3.33933157
6Hypothermia (HP:0002045)3.32810875
7Congenital stationary night blindness (HP:0007642)3.28545086
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.21152483
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.21152483
10Ketoacidosis (HP:0001993)3.17684770
11Anteriorly placed anus (HP:0001545)2.96466685
12Patchy hypopigmentation of hair (HP:0011365)2.95265027
13White forelock (HP:0002211)2.95086993
14Limb dystonia (HP:0002451)2.92862519
15Abnormality of the fovea (HP:0000493)2.89303426
16Hyperglycemia (HP:0003074)2.87738601
17Abnormal auditory evoked potentials (HP:0006958)2.85860672
18Segmental peripheral demyelination/remyelination (HP:0003481)2.85826729
19Abnormality of midbrain morphology (HP:0002418)2.84540417
20Molar tooth sign on MRI (HP:0002419)2.84540417
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.83986745
22Abnormality of the renal cortex (HP:0011035)2.81398968
23Nephronophthisis (HP:0000090)2.80712037
24Hypomagnesemia (HP:0002917)2.78367364
25Cerebral hypomyelination (HP:0006808)2.75301406
26Parakeratosis (HP:0001036)2.71211767
27Abnormality of the phalanges of the 2nd finger (HP:0009541)2.66958258
28Thyroiditis (HP:0100646)2.66704189
29Progressive neurologic deterioration (HP:0002344)2.66224073
30Adrenal hypoplasia (HP:0000835)2.65036191
31Peripheral hypomyelination (HP:0007182)2.64299542
32Abnormal hair whorl (HP:0010721)2.63217781
33Cerebral inclusion bodies (HP:0100314)2.63145577
34Renal cortical cysts (HP:0000803)2.58261238
35Myelomeningocele (HP:0002475)2.53743998
36Aplasia involving bones of the extremities (HP:0009825)2.52134707
37Aplasia involving bones of the upper limbs (HP:0009823)2.52134707
38Aplasia of the phalanges of the hand (HP:0009802)2.52134707
39Bell-shaped thorax (HP:0001591)2.51903978
40Abnormality of the pancreatic islet cells (HP:0006476)2.51111396
41Abnormality of endocrine pancreas physiology (HP:0012093)2.51111396
42Supranuclear gaze palsy (HP:0000605)2.48240883
43Premature rupture of membranes (HP:0001788)2.47678635
44Medial flaring of the eyebrow (HP:0010747)2.47556191
45Genital tract atresia (HP:0001827)2.47311330
46Aqueductal stenosis (HP:0002410)2.46840940
47Gait imbalance (HP:0002141)2.45918124
48Neoplasm of the adrenal cortex (HP:0100641)2.45722100
49Retinal dysplasia (HP:0007973)2.44873782
50Gaze-evoked nystagmus (HP:0000640)2.43524944
51Abnormality of vitamin B metabolism (HP:0004340)2.41359993
52Abnormal drinking behavior (HP:0030082)2.39709185
53Polydipsia (HP:0001959)2.39709185
54Abnormality of the renal medulla (HP:0100957)2.39085785
55Ketosis (HP:0001946)2.37427588
56Methylmalonic aciduria (HP:0012120)2.35239002
57Vaginal atresia (HP:0000148)2.34541642
58Attenuation of retinal blood vessels (HP:0007843)2.33705960
59Congenital primary aphakia (HP:0007707)2.32636853
60Abnormal rod and cone electroretinograms (HP:0008323)2.31838734
61Hyperinsulinemic hypoglycemia (HP:0000825)2.31687047
62Metaphyseal dysplasia (HP:0100255)2.28880864
63Stomatitis (HP:0010280)2.28228339
64Tongue fasciculations (HP:0001308)2.27768213
65Furrowed tongue (HP:0000221)2.24109613
66Onion bulb formation (HP:0003383)2.23798563
67Abolished electroretinogram (ERG) (HP:0000550)2.23523002
68Hematochezia (HP:0002573)2.19079055
69Hyperventilation (HP:0002883)2.19075746
70Aplasia/hypoplasia of the uterus (HP:0008684)2.18897001
71Progressive inability to walk (HP:0002505)2.16795564
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16020401
73Submucous cleft hard palate (HP:0000176)2.15429268
74Decreased lacrimation (HP:0000633)2.13309535
75Pancreatic fibrosis (HP:0100732)2.13092871
76Progressive macrocephaly (HP:0004481)2.13079191
77Fair hair (HP:0002286)2.12200948
78Nephrogenic diabetes insipidus (HP:0009806)2.11897872
793-Methylglutaconic aciduria (HP:0003535)2.10924920
80Thickened helices (HP:0000391)2.07740237
81Alacrima (HP:0000522)2.05855240
82Akinesia (HP:0002304)2.05789146
83Chronic hepatic failure (HP:0100626)2.05786598
84Hypoplastic pelvis (HP:0008839)2.05230094
85* Disproportionate short-trunk short stature (HP:0003521)2.04995193
86Abnormality of the corticospinal tract (HP:0002492)2.04540165
87Abnormality of the labia minora (HP:0012880)2.03704083
88Type II lissencephaly (HP:0007260)2.02960883
89Leukodystrophy (HP:0002415)2.02869862
90Type I transferrin isoform profile (HP:0003642)2.01673440
91Abnormality of methionine metabolism (HP:0010901)1.99813397
92Pheochromocytoma (HP:0002666)1.99776820
93Neuroendocrine neoplasm (HP:0100634)1.99110023
94Muscle fibrillation (HP:0010546)1.98506584
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98450211
96Cystic liver disease (HP:0006706)1.98234464
97Hypoplasia of the uterus (HP:0000013)1.97821128
98Abnormal protein glycosylation (HP:0012346)1.97313571
99Abnormal glycosylation (HP:0012345)1.97313571
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97313571
101Abnormal protein N-linked glycosylation (HP:0012347)1.97313571
102Atonic seizures (HP:0010819)1.97058265
103Flat capital femoral epiphysis (HP:0003370)1.96800984
104Hypoglycemic seizures (HP:0002173)1.96597650
105Aplasia/Hypoplasia of the lens (HP:0008063)1.96303187
106Autoamputation (HP:0001218)1.96231538
107Hemiparesis (HP:0001269)1.96088318
108Male pseudohermaphroditism (HP:0000037)1.96037342
109Large for gestational age (HP:0001520)1.95921772
110Abnormal biliary tract physiology (HP:0012439)1.94333259
111Bile duct proliferation (HP:0001408)1.94333259
112Increased CSF lactate (HP:0002490)1.93662983
113Febrile seizures (HP:0002373)1.93447903
114Abnormality of the pons (HP:0007361)1.93295850
115Blue irides (HP:0000635)1.92947027
116Symptomatic seizures (HP:0011145)1.92732338
117Hypoplastic left heart (HP:0004383)1.91652363
118Megalencephaly (HP:0001355)1.91361023
119True hermaphroditism (HP:0010459)1.91360698
120Albinism (HP:0001022)1.88573472
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.88166611
122Sensory axonal neuropathy (HP:0003390)1.88103009
123Scanning speech (HP:0002168)1.87380830
124Clumsiness (HP:0002312)1.86898449
125Broad-based gait (HP:0002136)1.86561884
126Congenital sensorineural hearing impairment (HP:0008527)1.86303583
127Abnormal biliary tract morphology (HP:0012440)1.85521185
128Insulin-resistant diabetes mellitus (HP:0000831)1.85436704
129Glycosuria (HP:0003076)1.85163262
130Abnormality of urine glucose concentration (HP:0011016)1.85163262
131Slow saccadic eye movements (HP:0000514)1.84913169
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84768293
133Pancreatic islet-cell hyperplasia (HP:0004510)1.84286133
134Tubular atrophy (HP:0000092)1.83915101
135Polyuria (HP:0000103)1.83625879
136Hypoalbuminemia (HP:0003073)1.83017186
137Abnormal albumin level (HP:0012116)1.83017186
138Hepatic necrosis (HP:0002605)1.82625097
139Acute necrotizing encephalopathy (HP:0006965)1.82294899
140CNS hypomyelination (HP:0003429)1.82025751
141Hypoplasia of the pons (HP:0012110)1.81380457
142Prominent metopic ridge (HP:0005487)1.80965598
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.79424251
144Increased circulating renin level (HP:0000848)1.79069312
145Hypoplasia of the iris (HP:0007676)1.78441567
146Stomach cancer (HP:0012126)1.77401373
147Neoplasm of the adrenal gland (HP:0100631)1.76820431
148Congenital, generalized hypertrichosis (HP:0004540)1.76745299
149Epileptic encephalopathy (HP:0200134)1.76266318
150Poor speech (HP:0002465)1.75513503
151Tracheomalacia (HP:0002779)1.75008633
152Ankle clonus (HP:0011448)1.73975231
153Abnormality of magnesium homeostasis (HP:0004921)1.73488487
154Abnormal pancreas size (HP:0012094)1.72816507
155Abnormality of alanine metabolism (HP:0010916)1.72610003
156Hyperalaninemia (HP:0003348)1.72610003
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72610003
158Abnormality of incisor morphology (HP:0011063)1.70064781
159Breast carcinoma (HP:0003002)1.69251889
160Ectopic anus (HP:0004397)1.68769694
161Generalized hypopigmentation of hair (HP:0011358)1.68676575
162Type I diabetes mellitus (HP:0100651)1.68503676
163Methylmalonic acidemia (HP:0002912)1.68255193
164Abnormality of the metopic suture (HP:0005556)1.68094950
165Inability to walk (HP:0002540)1.68062111
166Pendular nystagmus (HP:0012043)1.67522605
167Double outlet right ventricle (HP:0001719)1.67319570
168Congenital malformation of the right heart (HP:0011723)1.67319570
169Hamartoma of the eye (HP:0010568)1.67215031
170Meningocele (HP:0002435)1.67207084
171Intestinal atresia (HP:0011100)1.66944101
172Abnormality of calcium-phosphate metabolism (HP:0100530)1.66577205
173Irregular vertebral endplates (HP:0003301)1.66496617
174Hypoplastic heart (HP:0001961)1.66322644
175Absent septum pellucidum (HP:0001331)1.62361947
176Aplasia/Hypoplasia affecting the retina (HP:0008061)1.61812779
177Diminished movement (HP:0002374)1.58410608
178Morphological abnormality of the inner ear (HP:0011390)1.57931283
179Abnormality of dentin (HP:0010299)1.57646742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.41186317
2INSRR3.04068088
3MAPK153.03401640
4TRIM282.77184012
5NEK62.53791547
6MAP4K22.45012134
7BMPR1B2.43890008
8NUAK12.22425989
9OXSR12.19419884
10WNK42.15595801
11PINK12.07972720
12CASK2.02320802
13TNIK1.98218494
14ZAK1.80482145
15MET1.69131628
16SGK4941.68010731
17SGK2231.68010731
18PKN11.66278409
19MAP2K71.63376973
20BCR1.62795394
21WNK11.54337882
22IRAK11.52374012
23EPHB11.50127719
24MAPKAPK51.48278834
25DYRK21.48150227
26IRAK31.44120664
27PBK1.39591712
28UHMK11.38627297
29PLK31.37600307
30DAPK21.37003318
31MKNK21.32825335
32LIMK11.25636175
33MST41.24892038
34VRK11.23197681
35HIPK21.23027390
36TAOK31.21788398
37PRKCE1.21632207
38CAMK2B1.19996605
39IRAK21.19587042
40NTRK11.18818843
41BRSK21.17613028
42PNCK1.16714139
43STK241.16357214
44FER1.16093904
45BMPR21.12333169
46STK31.12111351
47IRAK41.11236916
48TGFBR11.07556186
49WNK31.04985741
50PLK21.04425881
51AKT31.00457283
52EIF2AK30.99270476
53CAMK2D0.97955336
54PAK30.96065626
55CSNK1G30.90728096
56MARK10.89613597
57TAF10.87679101
58EPHA30.86890135
59MAPK130.85139394
60PRKD30.84992965
61CLK10.84826198
62STK38L0.84690129
63CSNK1A1L0.84389314
64ADRBK20.83674115
65PASK0.82462215
66FGFR20.82279609
67WEE10.82100933
68PIK3CA0.81562484
69YES10.79906685
70TXK0.79350656
71NLK0.79251661
72GRK70.78792169
73PLK40.77544875
74ERBB30.74319225
75MKNK10.74103506
76CDK80.73562742
77CAMK2A0.73521877
78PRKCQ0.73042989
79PTK2B0.71190617
80CAMK2G0.70213490
81TIE10.69402353
82PRKCG0.68873750
83MAP3K120.68351893
84ARAF0.65817751
85MAP2K60.65558663
86TRPM70.63905669
87SGK20.63890770
88ACVR1B0.62725610
89CSNK1G10.61904510
90STK160.60890001
91PHKG10.59842140
92PHKG20.59842140
93CAMKK20.59349745
94TSSK60.58627071
95MUSK0.58556101
96MAP3K140.58437112
97FLT30.57768033
98PRKD20.56935074
99RPS6KA50.56690557
100FGFR30.55870430
101SIK30.55377864
102CSNK1G20.55033897
103MAPK70.54536603
104MAP3K60.54138998
105DYRK1A0.53529947
106CDK50.53002927
107PIM20.52844600
108MAP3K40.52672911
109MARK30.52415848
110CSNK1A10.52105254
111NTRK20.52054978
112FRK0.51057158
113ROCK20.49834272
114BRSK10.49583657
115TLK10.47491350
116GRK10.47118740
117MAP2K20.46781186
118ADRBK10.46503899
119IKBKB0.46179935
120MAP3K20.45999751
121NTRK30.45875954
122PRPF4B0.44312884
123TEC0.43646263
124PRKCI0.41568471
125CDK30.39565855
126PRKAA20.39442295
127MAP2K40.36177485
128EIF2AK10.35121938
129STK110.34468245
130ITK0.32714315
131TNK20.32625483
132PLK10.31728597
133PRKG10.30625795
134PRKAA10.29255694
135ATM0.26955480
136PRKACA0.26060008
137CSNK1D0.25478390
138ROCK10.25144932
139CHUK0.24907417
140EIF2AK20.23799006
141GRK50.23675349
142ABL10.22984014

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.88305627
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.73451878
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.75833093
4Steroid biosynthesis_Homo sapiens_hsa001002.64474396
5Butanoate metabolism_Homo sapiens_hsa006502.61775890
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45007890
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.33706400
8Ether lipid metabolism_Homo sapiens_hsa005652.21849918
9Selenocompound metabolism_Homo sapiens_hsa004502.21001125
10Fatty acid elongation_Homo sapiens_hsa000622.18343437
11Sphingolipid metabolism_Homo sapiens_hsa006002.09404263
12Sulfur metabolism_Homo sapiens_hsa009202.09004392
13Phototransduction_Homo sapiens_hsa047442.04171435
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98273459
15Propanoate metabolism_Homo sapiens_hsa006401.92126239
16Tryptophan metabolism_Homo sapiens_hsa003801.82953466
17Vibrio cholerae infection_Homo sapiens_hsa051101.77142266
18Serotonergic synapse_Homo sapiens_hsa047261.62280226
19Cocaine addiction_Homo sapiens_hsa050301.59912895
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59190778
21RNA polymerase_Homo sapiens_hsa030201.57125147
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.54639451
23Oxidative phosphorylation_Homo sapiens_hsa001901.52489596
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48235218
25Nitrogen metabolism_Homo sapiens_hsa009101.46650245
26Peroxisome_Homo sapiens_hsa041461.41214505
27Homologous recombination_Homo sapiens_hsa034401.40597282
28Caffeine metabolism_Homo sapiens_hsa002321.39814367
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37338374
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37034674
31Fanconi anemia pathway_Homo sapiens_hsa034601.34140939
32Type I diabetes mellitus_Homo sapiens_hsa049401.32120690
33GABAergic synapse_Homo sapiens_hsa047271.30684650
34Rheumatoid arthritis_Homo sapiens_hsa053231.27892465
35Insulin secretion_Homo sapiens_hsa049111.26701772
36Autoimmune thyroid disease_Homo sapiens_hsa053201.24435843
37Parkinsons disease_Homo sapiens_hsa050121.20974142
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20522947
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20139847
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17164911
41Regulation of autophagy_Homo sapiens_hsa041401.14143180
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13704806
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13689719
44Basal transcription factors_Homo sapiens_hsa030221.11179618
45Lysosome_Homo sapiens_hsa041421.08346386
46Folate biosynthesis_Homo sapiens_hsa007901.05989061
47Collecting duct acid secretion_Homo sapiens_hsa049661.05651629
48Phagosome_Homo sapiens_hsa041451.00438149
49Taste transduction_Homo sapiens_hsa047421.00113067
50Morphine addiction_Homo sapiens_hsa050320.99478460
51Alzheimers disease_Homo sapiens_hsa050100.99411192
52Glutamatergic synapse_Homo sapiens_hsa047240.97693078
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97407009
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97250824
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94488399
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92153475
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90962962
58Graft-versus-host disease_Homo sapiens_hsa053320.90462759
59Chemical carcinogenesis_Homo sapiens_hsa052040.89417256
60Circadian entrainment_Homo sapiens_hsa047130.89020225
61beta-Alanine metabolism_Homo sapiens_hsa004100.87872641
62Amphetamine addiction_Homo sapiens_hsa050310.84783412
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84511182
64Retinol metabolism_Homo sapiens_hsa008300.83013626
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82184051
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82059572
67Arachidonic acid metabolism_Homo sapiens_hsa005900.79864962
68ABC transporters_Homo sapiens_hsa020100.79718826
69Malaria_Homo sapiens_hsa051440.79698607
70One carbon pool by folate_Homo sapiens_hsa006700.77862902
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77803701
72Axon guidance_Homo sapiens_hsa043600.76710896
73Linoleic acid metabolism_Homo sapiens_hsa005910.76420140
74Fatty acid degradation_Homo sapiens_hsa000710.73583520
75Dopaminergic synapse_Homo sapiens_hsa047280.73439141
76Circadian rhythm_Homo sapiens_hsa047100.72747692
77Allograft rejection_Homo sapiens_hsa053300.71789104
78Long-term depression_Homo sapiens_hsa047300.69313899
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.69242181
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.69021727
81Other glycan degradation_Homo sapiens_hsa005110.68550950
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67608071
83Ovarian steroidogenesis_Homo sapiens_hsa049130.66460275
84Cholinergic synapse_Homo sapiens_hsa047250.66045265
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65342846
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63118129
87Synaptic vesicle cycle_Homo sapiens_hsa047210.62573968
88Huntingtons disease_Homo sapiens_hsa050160.62548468
89N-Glycan biosynthesis_Homo sapiens_hsa005100.62533834
90ECM-receptor interaction_Homo sapiens_hsa045120.62344416
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60896497
92Fatty acid metabolism_Homo sapiens_hsa012120.60522991
93Thyroid hormone synthesis_Homo sapiens_hsa049180.58013364
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57040094
95Pancreatic secretion_Homo sapiens_hsa049720.56136792
96Type II diabetes mellitus_Homo sapiens_hsa049300.55997009
97Metabolic pathways_Homo sapiens_hsa011000.54789181
98Nicotine addiction_Homo sapiens_hsa050330.54609764
99Ras signaling pathway_Homo sapiens_hsa040140.54365927
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.53361612
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52785368
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52491055
103Purine metabolism_Homo sapiens_hsa002300.51451573
104Olfactory transduction_Homo sapiens_hsa047400.51082234
105Alcoholism_Homo sapiens_hsa050340.48388448
106RNA degradation_Homo sapiens_hsa030180.48200944
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.47494110
108Legionellosis_Homo sapiens_hsa051340.47111677
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46146014
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45349218
111Pertussis_Homo sapiens_hsa051330.44892471
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43012669
113Mineral absorption_Homo sapiens_hsa049780.42459484
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42066245
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41623650
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41435861
117Renin secretion_Homo sapiens_hsa049240.41078473
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40556635
119Salivary secretion_Homo sapiens_hsa049700.39103624
120Lysine degradation_Homo sapiens_hsa003100.37900528
121Vitamin B6 metabolism_Homo sapiens_hsa007500.36506133
122Oocyte meiosis_Homo sapiens_hsa041140.36471151
123Histidine metabolism_Homo sapiens_hsa003400.36257733
124Dorso-ventral axis formation_Homo sapiens_hsa043200.36065444
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36050006
126Renal cell carcinoma_Homo sapiens_hsa052110.34495199
127Glutathione metabolism_Homo sapiens_hsa004800.34219525
128Wnt signaling pathway_Homo sapiens_hsa043100.33035203
129African trypanosomiasis_Homo sapiens_hsa051430.32910733
130Chemokine signaling pathway_Homo sapiens_hsa040620.32721704
131cAMP signaling pathway_Homo sapiens_hsa040240.32400865
132Endocytosis_Homo sapiens_hsa041440.32382147
133Proteasome_Homo sapiens_hsa030500.32103844
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31225652
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.31218856
136Non-homologous end-joining_Homo sapiens_hsa034500.30366818
137Prostate cancer_Homo sapiens_hsa052150.30206160
138ErbB signaling pathway_Homo sapiens_hsa040120.30078185
139MAPK signaling pathway_Homo sapiens_hsa040100.30029702
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29850679
141Fat digestion and absorption_Homo sapiens_hsa049750.28568896
142Vitamin digestion and absorption_Homo sapiens_hsa049770.27767242
143Hedgehog signaling pathway_Homo sapiens_hsa043400.26951365
144p53 signaling pathway_Homo sapiens_hsa041150.26660612
145RNA transport_Homo sapiens_hsa030130.24208980

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