RAB34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)4.83499944
2paraxial mesoderm development (GO:0048339)4.73413362
3establishment of integrated proviral latency (GO:0075713)4.70908519
4protein maturation by protein folding (GO:0022417)4.67663142
5chondrocyte proliferation (GO:0035988)4.66248647
6collagen fibril organization (GO:0030199)4.63664722
7sequestering of extracellular ligand from receptor (GO:0035581)4.33751296
8axon extension involved in axon guidance (GO:0048846)4.31665244
9neuron projection extension involved in neuron projection guidance (GO:1902284)4.31665244
10outer ear morphogenesis (GO:0042473)4.21070589
11bone trabecula formation (GO:0060346)4.18729858
12establishment of viral latency (GO:0019043)4.18586810
13metanephric mesenchyme development (GO:0072075)3.91536470
14mesenchymal cell differentiation involved in kidney development (GO:0072161)3.82495893
15mesenchymal cell differentiation involved in renal system development (GO:2001012)3.82495893
16ganglion development (GO:0061548)3.76269899
17protein retention in ER lumen (GO:0006621)3.73471453
18G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.65066656
19kidney mesenchyme development (GO:0072074)3.63361172
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.61995312
21dermatan sulfate biosynthetic process (GO:0030208)3.53945327
22heterochromatin organization (GO:0070828)3.53199255
23ventricular cardiac muscle cell development (GO:0055015)3.51568293
24extracellular negative regulation of signal transduction (GO:1900116)3.49601399
25extracellular regulation of signal transduction (GO:1900115)3.49601399
26DNA unwinding involved in DNA replication (GO:0006268)3.48060936
27middle ear morphogenesis (GO:0042474)3.44508732
28mesenchymal-epithelial cell signaling (GO:0060638)3.42242879
29negative regulation of chondrocyte differentiation (GO:0032331)3.40136180
30extracellular fibril organization (GO:0043206)3.37827565
31proteasome assembly (GO:0043248)3.33392011
32dermatan sulfate metabolic process (GO:0030205)3.32154223
33nucleobase-containing small molecule interconversion (GO:0015949)3.30362220
34skin morphogenesis (GO:0043589)3.29268373
35endothelial cell morphogenesis (GO:0001886)3.28982479
36mitotic nuclear envelope reassembly (GO:0007084)3.27511549
37nuclear envelope reassembly (GO:0031468)3.27511549
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26941897
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26089428
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24490456
41wound healing, spreading of epidermal cells (GO:0035313)3.22416217
42negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18804217
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18316478
44negative regulation of ligase activity (GO:0051352)3.18316478
45Golgi transport vesicle coating (GO:0048200)3.15565775
46COPI coating of Golgi vesicle (GO:0048205)3.15565775
47notochord development (GO:0030903)3.14337354
48DNA strand elongation involved in DNA replication (GO:0006271)3.12484437
49regulation of male gonad development (GO:2000018)3.11009204
50positive regulation of gastrulation (GO:2000543)3.10039277
51mesenchyme morphogenesis (GO:0072132)3.08366766
52epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.07967053
53DNA strand elongation (GO:0022616)3.07698101
54replicative senescence (GO:0090399)3.07135418
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06275251
56facial nerve structural organization (GO:0021612)3.04526599
57cell differentiation involved in metanephros development (GO:0072202)3.03831813
58negative regulation of cartilage development (GO:0061037)3.03515341
59formation of translation preinitiation complex (GO:0001731)3.03388368
60barbed-end actin filament capping (GO:0051016)3.02842289
61muscle cell migration (GO:0014812)3.00638817
62embryonic cranial skeleton morphogenesis (GO:0048701)2.98878899
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98460013
64mitotic metaphase plate congression (GO:0007080)2.98171349
65negative regulation of leukocyte chemotaxis (GO:0002689)2.97663595
66embryonic skeletal joint morphogenesis (GO:0060272)2.97645415
67neural crest cell development (GO:0014032)2.97079880
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.96352752
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95800667
70ribosome assembly (GO:0042255)2.95633191
71cell migration involved in heart development (GO:0060973)2.95165599
72regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.92475818
73cell proliferation involved in kidney development (GO:0072111)2.92377673
74negative regulation of stem cell proliferation (GO:2000647)2.92093552
75collagen metabolic process (GO:0032963)2.88985531
76craniofacial suture morphogenesis (GO:0097094)2.87590382
77L-serine metabolic process (GO:0006563)2.86634311
78telomere maintenance via semi-conservative replication (GO:0032201)2.84580222
79cochlea morphogenesis (GO:0090103)2.83956354
80negative regulation of embryonic development (GO:0045992)2.83914671
81collagen catabolic process (GO:0030574)2.83101720
82type B pancreatic cell proliferation (GO:0044342)2.83098950
83cell proliferation involved in metanephros development (GO:0072203)2.83018798
84negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.82633867
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82018905
86fibril organization (GO:0097435)2.80078848
87protein complex localization (GO:0031503)2.79225234
88regulation of non-canonical Wnt signaling pathway (GO:2000050)2.79010880
89retina vasculature morphogenesis in camera-type eye (GO:0061299)2.78140928
90positive regulation of cartilage development (GO:0061036)2.77380395
91Notch signaling involved in heart development (GO:0061314)2.76070775
92endodermal cell differentiation (GO:0035987)2.75161913
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.74269441
94wound healing, spreading of cells (GO:0044319)2.74000047
95negative regulation of axon guidance (GO:1902668)2.73606445
96mesenchymal cell differentiation (GO:0048762)2.72891500
97positive regulation of smoothened signaling pathway (GO:0045880)2.72415210
98positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.70818811
99endocardial cushion morphogenesis (GO:0003203)2.70338074
100ribosomal large subunit biogenesis (GO:0042273)2.70287600
101pentose-phosphate shunt (GO:0006098)2.70163053
102multicellular organismal macromolecule metabolic process (GO:0044259)2.69543896
103lateral sprouting from an epithelium (GO:0060601)2.67956965
104epithelial to mesenchymal transition (GO:0001837)2.67835250
105NADPH regeneration (GO:0006740)2.67769080
106mesenchymal cell proliferation (GO:0010463)2.66302567
107regulation of gastrulation (GO:0010470)2.65346209
108glomerulus development (GO:0032835)2.65114366
109negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.64872977
110UV protection (GO:0009650)2.64556723
111mesenchyme development (GO:0060485)2.63467935
112glomerular basement membrane development (GO:0032836)2.62668652
113regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62081503
114cell surface receptor signaling pathway involved in heart development (GO:0061311)2.61085616
115nephron epithelium morphogenesis (GO:0072088)2.60991882
116nephron tubule morphogenesis (GO:0072078)2.60991882
117regulation of mesoderm development (GO:2000380)2.59717350
118histone arginine methylation (GO:0034969)2.59362468
119pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.59039443
120negative regulation of axon extension involved in axon guidance (GO:0048843)2.58735063
121positive regulation of SMAD protein import into nucleus (GO:0060391)2.58090119
122mesenchymal cell development (GO:0014031)2.57783184
123regulation of spindle organization (GO:0090224)2.57394664
124nucleotide-sugar biosynthetic process (GO:0009226)2.55968122
125regulation of cellular amino acid metabolic process (GO:0006521)2.55963573
126regulation of translational termination (GO:0006449)2.55722691
127regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55523461
128regulation of cardioblast proliferation (GO:0003264)2.55523461
129embryonic camera-type eye development (GO:0031076)2.55484612
130cranial suture morphogenesis (GO:0060363)2.55271748
131mitotic chromosome condensation (GO:0007076)2.55230270
132mesonephric tubule development (GO:0072164)2.55178917
133multicellular organismal metabolic process (GO:0044236)2.53813485
134regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53610444
135regulation of cartilage development (GO:0061035)2.53104678
136female gonad development (GO:0008585)2.52542707
137cardiac epithelial to mesenchymal transition (GO:0060317)2.51322365
138protein localization to kinetochore (GO:0034501)2.49962401
139convergent extension (GO:0060026)2.49525316
140smooth muscle tissue development (GO:0048745)2.49310076
141peptidyl-arginine omega-N-methylation (GO:0035247)2.48948887
142multicellular organismal catabolic process (GO:0044243)2.48509714
143cellular response to vitamin (GO:0071295)2.47928472
144negative chemotaxis (GO:0050919)2.47155970
145hemidesmosome assembly (GO:0031581)2.46594910
146regulation of mitotic spindle organization (GO:0060236)2.46319627
147urogenital system development (GO:0001655)2.45604504
148atrial septum morphogenesis (GO:0060413)2.45105604
149metaphase plate congression (GO:0051310)2.44683400
150regulation of ubiquitin-protein transferase activity (GO:0051438)2.44570706
151cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.44376874
152ureteric bud development (GO:0001657)2.43974224
153embryonic skeletal system morphogenesis (GO:0048704)2.42968218
154regulation of cell fate specification (GO:0042659)2.42640248
155cell proliferation in forebrain (GO:0021846)2.42547480
156cellular protein complex localization (GO:0034629)2.42357939
157embryonic digit morphogenesis (GO:0042733)2.42286034
158ribosomal small subunit assembly (GO:0000028)2.42280844
159negative regulation of cell fate specification (GO:0009996)2.42032637
160positive regulation of embryonic development (GO:0040019)2.41740612
161omega-hydroxylase P450 pathway (GO:0097267)2.40781687
162pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.40681059
163DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.40184720
164signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.39701275
165intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.39701275
166negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.39671851
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.38136339
168signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.36918917
169signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.36918917
170signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.36918917
171apoptotic cell clearance (GO:0043277)2.35490799
172signal transduction involved in DNA integrity checkpoint (GO:0072401)2.34434843
173signal transduction involved in DNA damage checkpoint (GO:0072422)2.34434843
174cell adhesion mediated by integrin (GO:0033627)2.34073798
175regulation of ligase activity (GO:0051340)2.33550984
176IMP biosynthetic process (GO:0006188)2.32635326
177basement membrane organization (GO:0071711)2.31679949
178negative regulation of smooth muscle cell migration (GO:0014912)2.31169939
179guanosine-containing compound biosynthetic process (GO:1901070)2.31164353
180peptidyl-proline hydroxylation (GO:0019511)2.30348136
181lipopolysaccharide biosynthetic process (GO:0009103)2.29999518
182base-excision repair (GO:0006284)2.29800882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.14009275
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.10111979
3E2F7_22180533_ChIP-Seq_HELA_Human4.62664873
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.84027465
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81390682
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.57492208
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.46313082
8EED_16625203_ChIP-ChIP_MESCs_Mouse3.12308950
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93301484
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.74004280
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68674341
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66324967
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.61271620
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57583392
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42867580
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36645768
17GBX2_23144817_ChIP-Seq_PC3_Human2.35936790
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35799325
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.35441906
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33104947
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.32484556
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.32355782
23TP53_20018659_ChIP-ChIP_R1E_Mouse2.30170255
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29015175
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19842527
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18612652
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16481802
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11552629
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11510438
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10223029
31RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10223029
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.09782440
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.01017762
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98967825
35AR_21909140_ChIP-Seq_LNCAP_Human1.98510418
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97427752
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96808865
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95966362
39CJUN_26792858_Chip-Seq_BT549_Human1.95653616
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93652690
41* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91312642
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.88198238
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87810075
44TP53_18474530_ChIP-ChIP_U2OS_Human1.86765589
45XRN2_22483619_ChIP-Seq_HELA_Human1.86357015
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.86049635
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.85820064
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85704509
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83597873
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83296656
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79117193
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76897888
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.76120167
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75622844
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75585334
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.72973895
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71805741
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68722830
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.67978398
60DCP1A_22483619_ChIP-Seq_HELA_Human1.67276674
61BRD4_25478319_ChIP-Seq_HGPS_Human1.65659843
62ZNF263_19887448_ChIP-Seq_K562_Human1.61586455
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.61484251
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.59137336
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.59117519
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58786339
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57781740
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56922066
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56922066
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56922066
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.51956073
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51426584
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51141251
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51048385
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50242359
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49408007
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45903153
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41556809
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41485073
80TTF2_22483619_ChIP-Seq_HELA_Human1.39667840
81GABP_19822575_ChIP-Seq_HepG2_Human1.39500911
82* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39389897
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36750824
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.36237352
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33825718
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32359731
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.32081011
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30660224
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30565669
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.30398424
91* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30219073
92ATF3_27146783_Chip-Seq_COLON_Human1.28926262
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28300861
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.28194807
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27106915
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26576190
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.25458276
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25306735
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.23902074
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23713341
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23687348
102* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22904397
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22829445
104* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22661834
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21857831
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21382830
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18396936
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17760251
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17715370
110RACK7_27058665_Chip-Seq_MCF-7_Human1.16906138
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15821888
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14878853
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14840739
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14793068
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14723170
116* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14524026
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.13946444
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13935068
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13421319
120TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13125734
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12514654
122SOX2_16153702_ChIP-ChIP_HESCs_Human1.11974247
123TET1_21451524_ChIP-Seq_MESCs_Mouse1.11348898
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11019527
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.09509509
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09347607
127NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09276256
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09276256
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09099485
130* CLOCK_20551151_ChIP-Seq_293T_Human1.08317751
131SOX17_20123909_ChIP-Seq_XEN_Mouse1.07416571
132SRF_21415370_ChIP-Seq_HL-1_Mouse1.04958410
133EZH2_22144423_ChIP-Seq_EOC_Human1.04486706
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04354314
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04354314
136P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04261048
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04238518
138SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03090644
139RING1B_27294783_Chip-Seq_ESCs_Mouse1.02937034
140UBF1/2_26484160_Chip-Seq_HMECs_Human1.02674889
141LXR_22292898_ChIP-Seq_THP-1_Human1.02203700
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02078544
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01825555
144TP53_23651856_ChIP-Seq_MEFs_Mouse1.01813970
145ISL1_27105846_Chip-Seq_CPCs_Mouse1.01262411
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01123540
147PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00648702
148ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00631896
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00435397
150TP53_22127205_ChIP-Seq_IMR90_Human0.99668762
151TP53_16413492_ChIP-PET_HCT116_Human0.98554856
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98029046
153RNF2_27304074_Chip-Seq_NSC_Mouse0.97754192
154MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97598881
155NFI_21473784_ChIP-Seq_ESCs_Mouse0.97019782
156TFEB_21752829_ChIP-Seq_HELA_Human0.96136209
157SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95615937
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94999077
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94889378
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93431758
161ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92274546
162TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90738019
163GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90558847
164OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88953871
165ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88905980
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87859778
167SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87425656
168MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86753668
169EP300_21415370_ChIP-Seq_HL-1_Mouse0.86382078
170HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86037305
171SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85265289
172TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83074916
173EGR1_19374776_ChIP-ChIP_THP-1_Human0.82740488
174EWS_26573619_Chip-Seq_HEK293_Human0.82295806
175* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81192478
176* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.80472084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.07697942
2MP0005503_abnormal_tendon_morphology4.47766545
3MP0010030_abnormal_orbit_morphology3.78986760
4MP0005275_abnormal_skin_tensile3.57903123
5MP0003279_aneurysm3.01207715
6MP0000566_synostosis2.77764285
7MP0005257_abnormal_intraocular_pressure2.59831219
8MP0001958_emphysema2.49801802
9MP0003941_abnormal_skin_development2.42001936
10MP0000049_abnormal_middle_ear2.40992105
11MP0005508_abnormal_skeleton_morphology2.21904302
12MP0009250_abnormal_appendicular_skeleto2.12435111
13MP0009384_cardiac_valve_regurgitation2.12048260
14MP0004272_abnormal_basement_membrane2.10991426
15MP0005171_absent_coat_pigmentation2.05887864
16MP0003693_abnormal_embryo_hatching2.02064957
17MP0003385_abnormal_body_wall1.99257460
18MP0004957_abnormal_blastocyst_morpholog1.95975212
19MP0002254_reproductive_system_inflammat1.94844237
20MP0002249_abnormal_larynx_morphology1.93805694
21MP0003942_abnormal_urinary_system1.82928255
22MP0000751_myopathy1.82756139
23MP0010368_abnormal_lymphatic_system1.82345571
24MP0000678_abnormal_parathyroid_gland1.80503486
25MP0001188_hyperpigmentation1.79636405
26MP0003950_abnormal_plasma_membrane1.79039827
27MP0003111_abnormal_nucleus_morphology1.76329730
28MP0001849_ear_inflammation1.76202606
29MP0003705_abnormal_hypodermis_morpholog1.68060385
30MP0003755_abnormal_palate_morphology1.65314340
31MP0006292_abnormal_olfactory_placode1.65129383
32MP0002060_abnormal_skin_morphology1.62859378
33MP0010352_gastrointestinal_tract_polyps1.57852497
34MP0003283_abnormal_digestive_organ1.57609155
35MP0002938_white_spotting1.52200302
36MP0003937_abnormal_limbs/digits/tail_de1.50940547
37MP0003077_abnormal_cell_cycle1.50315825
38MP0000762_abnormal_tongue_morphology1.48233113
39MP0000163_abnormal_cartilage_morphology1.44455764
40MP0010386_abnormal_urinary_bladder1.42800285
41MP0002932_abnormal_joint_morphology1.41257389
42MP0005623_abnormal_meninges_morphology1.39662058
43MP0002116_abnormal_craniofacial_bone1.37632541
44MP0005670_abnormal_white_adipose1.37235193
45MP0000428_abnormal_craniofacial_morphol1.36152453
46MP0004858_abnormal_nervous_system1.34965614
47MP0004133_heterotaxia1.31882714
48MP0002177_abnormal_outer_ear1.31067968
49MP0004134_abnormal_chest_morphology1.30342820
50MP0003186_abnormal_redox_activity1.28354125
51MP0000750_abnormal_muscle_regeneration1.28007109
52MP0002233_abnormal_nose_morphology1.27483040
53MP0000534_abnormal_ureter_morphology1.27157390
54MP0003122_maternal_imprinting1.26745925
55MP0004233_abnormal_muscle_weight1.24383697
56MP0001299_abnormal_eye_distance/1.23916353
57MP0010094_abnormal_chromosome_stability1.22705786
58MP0002108_abnormal_muscle_morphology1.21965254
59MP0000350_abnormal_cell_proliferation1.20070276
60MP0000432_abnormal_head_morphology1.19731787
61MP0009053_abnormal_anal_canal1.19148640
62MP0003935_abnormal_craniofacial_develop1.18005217
63MP0002896_abnormal_bone_mineralization1.16880349
64MP0002115_abnormal_skeleton_extremities1.16773909
65MP0002109_abnormal_limb_morphology1.16669396
66MP0001730_embryonic_growth_arrest1.16187799
67MP0002111_abnormal_tail_morphology1.13599712
68MP0003115_abnormal_respiratory_system1.12229736
69MP0003806_abnormal_nucleotide_metabolis1.10294116
70MP0002295_abnormal_pulmonary_circulatio1.09869416
71MP0005377_hearing/vestibular/ear_phenot1.08145264
72MP0003878_abnormal_ear_physiology1.08145264
73MP0003136_yellow_coat_color1.08105307
74MP0001542_abnormal_bone_strength1.06528087
75MP0008789_abnormal_olfactory_epithelium1.06235207
76MP0005248_abnormal_Harderian_gland1.05873824
77MP0002113_abnormal_skeleton_development1.03259440
78MP0002085_abnormal_embryonic_tissue1.03058053
79MP0008058_abnormal_DNA_repair1.02680010
80MP0000537_abnormal_urethra_morphology1.01992282
81MP0008007_abnormal_cellular_replicative1.01490930
82MP0002282_abnormal_trachea_morphology1.01373435
83MP0005390_skeleton_phenotype1.00892232
84MP0005501_abnormal_skin_physiology1.00228532
85MP0002653_abnormal_ependyma_morphology0.99829549
86MP0002102_abnormal_ear_morphology0.98838081
87MP0001915_intracranial_hemorrhage0.97632312
88MP0005165_increased_susceptibility_to0.96666552
89MP0005058_abnormal_lysosome_morphology0.96532280
90MP0001177_atelectasis0.95355667
91MP0000358_abnormal_cell_content/0.94384764
92MP0002080_prenatal_lethality0.93948133
93MP0003123_paternal_imprinting0.93451913
94MP0003121_genomic_imprinting0.92802378
95MP0003119_abnormal_digestive_system0.92552317
96MP0000858_altered_metastatic_potential0.91371743
97MP0000733_abnormal_muscle_development0.91266585
98MP0002114_abnormal_axial_skeleton0.90696676
99MP0003191_abnormal_cellular_cholesterol0.90357886
100MP0009672_abnormal_birth_weight0.90173886
101MP0003566_abnormal_cell_adhesion0.89412593
102MP0001661_extended_life_span0.89105669
103MP0005193_abnormal_anterior_eye0.88635437
104MP0003786_premature_aging0.87677206
105MP0002877_abnormal_melanocyte_morpholog0.87322167
106MP0008260_abnormal_autophagy0.86012820
107MP0000749_muscle_degeneration0.85638882
108MP0005380_embryogenesis_phenotype0.84611173
109MP0001672_abnormal_embryogenesis/_devel0.84611173
110MP0009278_abnormal_bone_marrow0.84315065
111MP0009379_abnormal_foot_pigmentation0.83786092
112MP0002084_abnormal_developmental_patter0.83752178
113MP0002796_impaired_skin_barrier0.82527266
114MP0005023_abnormal_wound_healing0.82453891
115MP0001286_abnormal_eye_development0.81936546
116MP0000767_abnormal_smooth_muscle0.80846740
117MP0002751_abnormal_autonomic_nervous0.80005551
118MP0001270_distended_abdomen0.78861818
119MP0001243_abnormal_dermal_layer0.78652445
120MP0001697_abnormal_embryo_size0.78442454
121MP0003938_abnormal_ear_development0.78272043
122MP0005197_abnormal_uvea_morphology0.77991874
123MP0000681_abnormal_thyroid_gland0.77455117
124MP0002697_abnormal_eye_size0.76971778
125MP0005595_abnormal_vascular_smooth0.76824913
126MP0000343_altered_response_to0.76699078
127MP0000003_abnormal_adipose_tissue0.76661564
128MP0001879_abnormal_lymphatic_vessel0.76561210
129MP0002168_other_aberrant_phenotype0.76089269
130MP0000516_abnormal_urinary_system0.75391908
131MP0005367_renal/urinary_system_phenotyp0.75391908
132MP0005621_abnormal_cell_physiology0.75359392
133MP0003984_embryonic_growth_retardation0.74793463
134MP0001175_abnormal_lung_morphology0.74142273
135MP0001853_heart_inflammation0.74133350
136MP0000759_abnormal_skeletal_muscle0.74113542
137MP0003448_altered_tumor_morphology0.74064610
138MP0006054_spinal_hemorrhage0.73928829
139MP0000467_abnormal_esophagus_morphology0.73712580
140MP0000015_abnormal_ear_pigmentation0.73581219
141MP0000026_abnormal_inner_ear0.73369405
142MP0005330_cardiomyopathy0.73269066
143MP0000372_irregular_coat_pigmentation0.73216569
144MP0009697_abnormal_copulation0.73113065
145MP0002933_joint_inflammation0.71293530
146MP0008932_abnormal_embryonic_tissue0.70390480
147MP0002638_abnormal_pupillary_reflex0.70224789
148MP0003091_abnormal_cell_migration0.70137701
149MP0001186_pigmentation_phenotype0.69382883
150MP0000538_abnormal_urinary_bladder0.67202099
151MP0000013_abnormal_adipose_tissue0.66213640

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.78735862
2Protrusio acetabuli (HP:0003179)5.01690117
3Soft skin (HP:0000977)3.82024862
4Neonatal short-limb short stature (HP:0008921)3.64265959
5Abnormality of dentin (HP:0010299)3.54486638
6Atrophic scars (HP:0001075)3.46843910
7Selective tooth agenesis (HP:0001592)3.22763974
8Bladder diverticulum (HP:0000015)3.07922970
9Shallow orbits (HP:0000586)3.07302545
10Follicular hyperkeratosis (HP:0007502)3.02514824
11Osteolytic defects of the hand bones (HP:0009699)2.97184847
12Osteolytic defects of the phalanges of the hand (HP:0009771)2.97184847
13Ankle contracture (HP:0006466)2.93707090
14Fragile skin (HP:0001030)2.91796236
15Aortic dissection (HP:0002647)2.90418472
16Abnormality of the umbilical cord (HP:0010881)2.84935706
17Mesomelia (HP:0003027)2.83132030
18Cervical subluxation (HP:0003308)2.66123894
19Bell-shaped thorax (HP:0001591)2.60692935
20Trismus (HP:0000211)2.55424642
21Morphological abnormality of the middle ear (HP:0008609)2.52327492
22Ulnar bowing (HP:0003031)2.50406196
23Broad metatarsal (HP:0001783)2.49987001
24Generalized amyotrophy (HP:0003700)2.46945311
25Spinal rigidity (HP:0003306)2.43739379
26Wormian bones (HP:0002645)2.40672697
27Rough bone trabeculation (HP:0100670)2.39678010
28Achilles tendon contracture (HP:0001771)2.38792002
29Delayed cranial suture closure (HP:0000270)2.36443760
30Wrist flexion contracture (HP:0001239)2.36041115
31Blue sclerae (HP:0000592)2.31503355
32Reduced subcutaneous adipose tissue (HP:0003758)2.27584433
33Increased connective tissue (HP:0009025)2.27336348
34Aortic aneurysm (HP:0004942)2.24900973
35Vertebral compression fractures (HP:0002953)2.24497359
36Dilatation of the ascending aorta (HP:0005111)2.24027101
37Abnormality of the fetal cardiovascular system (HP:0010948)2.23693729
38Abnormal umbilical cord blood vessels (HP:0011403)2.23693729
39Single umbilical artery (HP:0001195)2.23693729
40Biconcave vertebral bodies (HP:0004586)2.22912184
41Entropion (HP:0000621)2.21564799
42Aplasia involving bones of the extremities (HP:0009825)2.19873780
43Aplasia involving bones of the upper limbs (HP:0009823)2.19873780
44Aplasia of the phalanges of the hand (HP:0009802)2.19873780
45Distal lower limb muscle weakness (HP:0009053)2.17747451
46Natal tooth (HP:0000695)2.17583184
47Vascular tortuosity (HP:0004948)2.15903829
48Upper limb muscle weakness (HP:0003484)2.13267117
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09987869
50Spastic diplegia (HP:0001264)2.08730587
51Synostosis of carpal bones (HP:0005048)2.07809851
52Bowel diverticulosis (HP:0005222)2.06979587
53Hyperacusis (HP:0010780)2.06952783
54Syringomyelia (HP:0003396)2.04398969
55Spinal cord lesions (HP:0100561)2.04398969
56Septo-optic dysplasia (HP:0100842)2.03450900
57Cerebral aneurysm (HP:0004944)2.02037965
58Short clavicles (HP:0000894)1.98336685
59Redundant skin (HP:0001582)1.97002174
60Limb-girdle muscle atrophy (HP:0003797)1.95745293
61Abnormalities of placenta or umbilical cord (HP:0001194)1.95735463
62Coronal craniosynostosis (HP:0004440)1.94671941
63Ectopia lentis (HP:0001083)1.94092588
64Carpal synostosis (HP:0009702)1.93679122
65Mitral regurgitation (HP:0001653)1.92840777
66Type 1 muscle fiber predominance (HP:0003803)1.92264030
67Abnormality of the Achilles tendon (HP:0005109)1.91604995
68Breech presentation (HP:0001623)1.91457351
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91297540
70Protruding ear (HP:0000411)1.90515402
71Distal lower limb amyotrophy (HP:0008944)1.88687522
72Mitral valve prolapse (HP:0001634)1.88008958
73Joint laxity (HP:0001388)1.87587111
74Distal upper limb amyotrophy (HP:0007149)1.87426451
75Upper limb amyotrophy (HP:0009129)1.87426451
76Joint stiffness (HP:0001387)1.86734508
77Spondylolisthesis (HP:0003302)1.86489952
78Short hallux (HP:0010109)1.85202544
79Pulmonary artery stenosis (HP:0004415)1.84733209
80Overgrowth (HP:0001548)1.84455462
81Tarsal synostosis (HP:0008368)1.84260130
82Elbow flexion contracture (HP:0002987)1.81528337
83Synostosis involving bones of the feet (HP:0009140)1.79785818
84Synostosis involving bones of the lower limbs (HP:0009138)1.79785818
85Pterygium (HP:0001059)1.79507825
86Abnormality of the renal collecting system (HP:0004742)1.79327420
87Nonimmune hydrops fetalis (HP:0001790)1.79147533
88Neoplasm of the adrenal cortex (HP:0100641)1.78959386
89Arterial tortuosity (HP:0005116)1.78040680
90Short middle phalanx of the 5th finger (HP:0004220)1.76708594
91Narrow nasal bridge (HP:0000446)1.76642145
92Short nail (HP:0001799)1.76245928
93Shoulder girdle muscle weakness (HP:0003547)1.75725887
94Premature skin wrinkling (HP:0100678)1.74940547
95Abnormality of the middle phalanges of the toes (HP:0010183)1.74765533
96Deviation of the thumb (HP:0009603)1.74712773
97Abnormality of the nasal septum (HP:0000419)1.74469494
98Deviation of the hallux (HP:0010051)1.73711097
99Abnormal number of incisors (HP:0011064)1.73429529
100Stomach cancer (HP:0012126)1.72352190
101Hydroureter (HP:0000072)1.72088756
102Aplasia/Hypoplasia of the clavicles (HP:0006710)1.71356099
103Deformed tarsal bones (HP:0008119)1.70284251
104Calcaneovalgus deformity (HP:0001848)1.69951067
105Hyperextensible skin (HP:0000974)1.68084075
106Proximal placement of thumb (HP:0009623)1.68013925
107Peritonitis (HP:0002586)1.66952335
108Abnormal trabecular bone morphology (HP:0100671)1.66646858
109Facial cleft (HP:0002006)1.66062874
110Slender build (HP:0001533)1.65040519
111Reticulocytopenia (HP:0001896)1.64862525
112Short 4th metacarpal (HP:0010044)1.64798728
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64798728
114Genu recurvatum (HP:0002816)1.64724943
115Renal duplication (HP:0000075)1.64496285
116Disproportionate tall stature (HP:0001519)1.64362423
117Limb-girdle muscle weakness (HP:0003325)1.63645159
118Fibular hypoplasia (HP:0003038)1.63295553
119Broad long bones (HP:0005622)1.63077855
120Abnormal delivery (HP:0001787)1.62992882
121Long toe (HP:0010511)1.62978265
122Thin ribs (HP:0000883)1.62930305
123Mildly elevated creatine phosphokinase (HP:0008180)1.62719890
124Wide anterior fontanel (HP:0000260)1.62592340
125Long palpebral fissure (HP:0000637)1.61770460
126Abnormality of skull ossification (HP:0002703)1.61556034
127Abnormality of the nasolacrimal system (HP:0000614)1.61533834
128Synostosis involving bones of the hand (HP:0004278)1.60261655
129Broad toe (HP:0001837)1.60155631
130Down-sloping shoulders (HP:0200021)1.60121702
131Femoral bowing (HP:0002980)1.59975510
132Fibular aplasia (HP:0002990)1.59603667
133Aplasia/Hypoplasia of the fibula (HP:0006492)1.58481214
134Abnormal sex determination (HP:0012244)1.58108296
135Sex reversal (HP:0012245)1.58108296
136Difficulty climbing stairs (HP:0003551)1.58032041
137Hallux valgus (HP:0001822)1.57525433
138Progressive muscle weakness (HP:0003323)1.56773847
139True hermaphroditism (HP:0010459)1.56005054
140Adrenal hypoplasia (HP:0000835)1.54627332
141Hand muscle atrophy (HP:0009130)1.54260794
142Abnormality of incisor morphology (HP:0011063)1.54205842
143Abnormality of skeletal muscle fiber size (HP:0012084)1.54124365
144Aplasia/Hypoplasia of the hallux (HP:0008362)1.53108753
145Abnormality of the distal phalanges of the toes (HP:0010182)1.52399265
146Unilateral renal agenesis (HP:0000122)1.51776593
147Abnormality of the acetabulum (HP:0003170)1.51477103
148Abnormality of the parietal bone (HP:0002696)1.50426889
149Chromsome breakage (HP:0040012)1.50407516
150Cutaneous finger syndactyly (HP:0010554)1.50058831
151Mild short stature (HP:0003502)1.48479984
152Abnormality of the phalanges of the 5th finger (HP:0004213)1.47753724
153Decreased skull ossification (HP:0004331)1.47739154
154Nasolacrimal duct obstruction (HP:0000579)1.47433490
155Platyspondyly (HP:0000926)1.47016161
156Flat capital femoral epiphysis (HP:0003370)1.46984146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.38827726
2VRK23.94162023
3DDR23.72550105
4STK38L3.14249308
5EPHB23.03068607
6LATS22.83326824
7LATS12.49197276
8ERBB32.48146886
9IRAK32.38683737
10MYLK2.27234186
11SMG12.18942589
12TESK22.10712612
13INSRR2.06482958
14PDGFRA2.00191602
15FLT31.90228508
16EPHA31.85513331
17ARAF1.84992898
18MKNK21.83808077
19SRPK11.83775538
20MKNK11.83537484
21EPHA21.80955687
22NEK11.79452813
23TAOK21.79322545
24FER1.69518284
25TAF11.65405752
26CDC71.65220585
27ABL21.60850808
28EIF2AK21.56158243
29TTK1.55510011
30PRPF4B1.46899969
31IRAK11.44010598
32KDR1.40497005
33NEK61.40383089
34NTRK11.24641828
35PLK31.21778780
36PASK1.19467279
37ILK1.16253028
38BCKDK1.14846326
39TGFBR21.13344976
40MAP3K31.12294991
41TTN1.09854086
42RPS6KA41.07974744
43NUAK11.07874322
44PRKD21.07261160
45MET1.07139563
46FGFR11.06698556
47DAPK31.05095852
48TSSK61.04101821
49TRPM71.04066022
50IRAK21.00488503
51ERN11.00267437
52AKT30.99441823
53VRK10.93472356
54CDK30.92684736
55TNIK0.92335752
56DAPK10.91783007
57TLK10.90865020
58PIK3CA0.90562541
59MAP3K80.90083169
60BRD40.89677483
61PTK20.89596507
62BMPR20.89518936
63BMX0.88773680
64PAK20.88382508
65CDC42BPA0.88200389
66FRK0.87829144
67LMTK20.86698384
68IRAK40.86303495
69STK100.85306397
70BRSK10.84834005
71CDK70.84785713
72CDK80.84227915
73CDK190.83078806
74MAP3K90.82958479
75TRIB30.82459056
76MST1R0.81718679
77CHEK20.80753786
78PRKD30.80623210
79ATR0.79787171
80YES10.78108624
81PLK40.77636492
82PAK30.77532872
83PLK10.77017596
84DYRK20.75826833
85TESK10.74608154
86NEK20.73977980
87PDK20.73878420
88MAP3K120.73276048
89NLK0.72408037
90ROCK10.72334899
91SIK10.71724680
92STK30.71408807
93BMPR1B0.68535546
94LIMK10.64927446
95PRKCE0.64375355
96STK160.63394635
97BRAF0.63256533
98ICK0.63086127
99PIK3CG0.62679043
100CSNK1G30.62483120
101AURKA0.60980074
102AURKB0.60900760
103SCYL20.60601869
104MAP2K10.59773603
105CASK0.59230358
106BUB10.58981526
107PLK20.58491652
108MAPK150.57764692
109CHUK0.57385200
110NME20.57094675
111NEK90.55167427
112STK40.53888590
113PRKCI0.52458625
114PBK0.52083326
115WEE10.52040279
116WNK30.51719615
117SGK20.51688442
118PTK60.51537291
119AKT10.50258052
120CSNK1G10.49512480
121LRRK20.48849738
122MAPK130.48657661
123CSNK1A1L0.48610222
124DMPK0.48304480
125NTRK30.48303445
126MOS0.46898738
127ROCK20.46822118
128ERBB20.46203099
129MTOR0.45870468
130CDK11A0.45221306
131WNK10.43261580
132EIF2AK10.43127591
133MELK0.43054985
134INSR0.42582515
135CDK150.40977347
136PIM20.40184136
137MAPK70.39994676
138CDK180.39695673
139NME10.39189583
140PRKG20.38694051
141CHEK10.38641175
142CDK140.38195900
143GSK3A0.38144146
144GRK50.37300543
145PAK40.36457134
146WNK40.35741859
147AKT20.34976403
148MAP2K30.34911188
149CDK90.33783759
150PAK10.33479013
151MAP2K20.32446018
152ERBB40.32046589
153MAP3K110.31712291
154CAMK1D0.31034772
155TGFBR10.30874807

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.01813972
2Basal cell carcinoma_Homo sapiens_hsa052173.22564470
3ECM-receptor interaction_Homo sapiens_hsa045123.05946458
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.76441445
5Hedgehog signaling pathway_Homo sapiens_hsa043402.55549345
6Ribosome_Homo sapiens_hsa030102.49412972
7Sulfur relay system_Homo sapiens_hsa041222.24711603
8Hippo signaling pathway_Homo sapiens_hsa043902.13426044
9Biosynthesis of amino acids_Homo sapiens_hsa012301.99303092
10TGF-beta signaling pathway_Homo sapiens_hsa043501.96973958
11Protein digestion and absorption_Homo sapiens_hsa049741.92139424
12Fanconi anemia pathway_Homo sapiens_hsa034601.91797794
13p53 signaling pathway_Homo sapiens_hsa041151.79877840
14Galactose metabolism_Homo sapiens_hsa000521.77517499
15Pentose phosphate pathway_Homo sapiens_hsa000301.74380074
16Adherens junction_Homo sapiens_hsa045201.72901622
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72213178
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70637697
19Focal adhesion_Homo sapiens_hsa045101.70448327
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68098720
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63785469
22Wnt signaling pathway_Homo sapiens_hsa043101.59424664
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.56106762
24Proteoglycans in cancer_Homo sapiens_hsa052051.50960271
25Melanoma_Homo sapiens_hsa052181.48459748
26Arachidonic acid metabolism_Homo sapiens_hsa005901.47843182
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.45307566
28Bladder cancer_Homo sapiens_hsa052191.44411216
29Fatty acid elongation_Homo sapiens_hsa000621.43426552
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43195680
31MicroRNAs in cancer_Homo sapiens_hsa052061.39471969
32Carbon metabolism_Homo sapiens_hsa012001.35813812
33Folate biosynthesis_Homo sapiens_hsa007901.33536370
34Homologous recombination_Homo sapiens_hsa034401.29592695
35RNA polymerase_Homo sapiens_hsa030201.28917173
36Cell cycle_Homo sapiens_hsa041101.27750899
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26689145
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22535609
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21640532
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.21360351
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.20744134
42Protein export_Homo sapiens_hsa030601.19763702
43Notch signaling pathway_Homo sapiens_hsa043301.19063276
44Prostate cancer_Homo sapiens_hsa052151.17774504
45Other glycan degradation_Homo sapiens_hsa005111.17122226
46Pyruvate metabolism_Homo sapiens_hsa006201.16214364
47Small cell lung cancer_Homo sapiens_hsa052221.13769731
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12695159
49Vitamin B6 metabolism_Homo sapiens_hsa007501.11324907
50Axon guidance_Homo sapiens_hsa043601.10621091
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09098907
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08019908
53Base excision repair_Homo sapiens_hsa034101.05742064
54Malaria_Homo sapiens_hsa051441.05725838
55Pathways in cancer_Homo sapiens_hsa052001.05548506
56Huntingtons disease_Homo sapiens_hsa050161.02239533
57Melanogenesis_Homo sapiens_hsa049160.97739781
58HTLV-I infection_Homo sapiens_hsa051660.96482713
59Nucleotide excision repair_Homo sapiens_hsa034200.96031059
60Dilated cardiomyopathy_Homo sapiens_hsa054140.96014577
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95237101
62Sulfur metabolism_Homo sapiens_hsa009200.95105657
63Fructose and mannose metabolism_Homo sapiens_hsa000510.93544191
64Basal transcription factors_Homo sapiens_hsa030220.93120429
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91974847
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89853020
67One carbon pool by folate_Homo sapiens_hsa006700.89609380
68N-Glycan biosynthesis_Homo sapiens_hsa005100.88594243
69Shigellosis_Homo sapiens_hsa051310.88567085
70Sphingolipid metabolism_Homo sapiens_hsa006000.86927437
71Parkinsons disease_Homo sapiens_hsa050120.86531915
72Endometrial cancer_Homo sapiens_hsa052130.85261012
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84410719
74Amoebiasis_Homo sapiens_hsa051460.83471890
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.79431070
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79362087
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77594933
78Spliceosome_Homo sapiens_hsa030400.76662981
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76476452
80RNA transport_Homo sapiens_hsa030130.75650269
81Oxidative phosphorylation_Homo sapiens_hsa001900.74584022
82mRNA surveillance pathway_Homo sapiens_hsa030150.72871762
83Ovarian steroidogenesis_Homo sapiens_hsa049130.72153219
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71459051
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71458768
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71240744
87Tight junction_Homo sapiens_hsa045300.68964636
88Chronic myeloid leukemia_Homo sapiens_hsa052200.68318767
89Mismatch repair_Homo sapiens_hsa034300.68223864
90Selenocompound metabolism_Homo sapiens_hsa004500.67851126
91TNF signaling pathway_Homo sapiens_hsa046680.67745472
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67361366
93Pyrimidine metabolism_Homo sapiens_hsa002400.67086289
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64801756
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64451723
96Alzheimers disease_Homo sapiens_hsa050100.63738724
97Rap1 signaling pathway_Homo sapiens_hsa040150.63516858
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63456875
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62238509
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61658217
101Purine metabolism_Homo sapiens_hsa002300.60259019
102Vibrio cholerae infection_Homo sapiens_hsa051100.58805812
103Mineral absorption_Homo sapiens_hsa049780.55582716
104Phagosome_Homo sapiens_hsa041450.55110528
105Rheumatoid arthritis_Homo sapiens_hsa053230.52849248
106Non-homologous end-joining_Homo sapiens_hsa034500.52180134
107Thyroid cancer_Homo sapiens_hsa052160.50704060
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.49834678
109Apoptosis_Homo sapiens_hsa042100.47694574
110Circadian rhythm_Homo sapiens_hsa047100.47384039
111Lysosome_Homo sapiens_hsa041420.47276672
112Colorectal cancer_Homo sapiens_hsa052100.46589222
113RNA degradation_Homo sapiens_hsa030180.46579594
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45568800
115Ras signaling pathway_Homo sapiens_hsa040140.45240130
116Glutathione metabolism_Homo sapiens_hsa004800.44244208
117Cocaine addiction_Homo sapiens_hsa050300.42939952
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42936641
119Metabolic pathways_Homo sapiens_hsa011000.42011206
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40460716
121Epstein-Barr virus infection_Homo sapiens_hsa051690.40196348
122FoxO signaling pathway_Homo sapiens_hsa040680.38671980
123Vitamin digestion and absorption_Homo sapiens_hsa049770.38186313
124Salmonella infection_Homo sapiens_hsa051320.37523446
125DNA replication_Homo sapiens_hsa030300.36477301
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.36193750
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.35561810
128Viral carcinogenesis_Homo sapiens_hsa052030.35560711
129Autoimmune thyroid disease_Homo sapiens_hsa053200.34199840
130Fatty acid biosynthesis_Homo sapiens_hsa000610.33072288
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32557415
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32422846
133Arginine and proline metabolism_Homo sapiens_hsa003300.29918317
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.29524378
135Gap junction_Homo sapiens_hsa045400.29283825

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