RAB37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.41678000
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.41678000
3Golgi transport vesicle coating (GO:0048200)6.12928091
4COPI coating of Golgi vesicle (GO:0048205)6.12928091
5neutrophil activation involved in immune response (GO:0002283)5.85612501
6signal peptide processing (GO:0006465)5.73160829
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.66953742
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.66953742
9antigen processing and presentation of endogenous antigen (GO:0019883)4.59662553
10antigen processing and presentation via MHC class Ib (GO:0002475)4.52899903
11neutrophil activation (GO:0042119)4.35510722
12negative regulation of glycoprotein biosynthetic process (GO:0010561)4.29216913
13positive regulation of gamma-delta T cell activation (GO:0046645)4.22561869
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14991603
15regulation of mast cell degranulation (GO:0043304)4.11364304
16negative regulation of lymphocyte mediated immunity (GO:0002707)4.10635013
17peptide hormone processing (GO:0016486)4.05093137
18protein maturation by protein folding (GO:0022417)4.04987652
19positive regulation by symbiont of host defense response (GO:0052509)4.04552142
20modulation by symbiont of host defense response (GO:0052031)4.04552142
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.04552142
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.04552142
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.04552142
24modulation by symbiont of host immune response (GO:0052553)4.04552142
25mast cell activation (GO:0045576)3.98118494
26detection of other organism (GO:0098543)3.97975686
27detection of bacterium (GO:0016045)3.96215728
28immunoglobulin mediated immune response (GO:0016064)3.95614738
29endocrine pancreas development (GO:0031018)3.93857812
30polyketide metabolic process (GO:0030638)3.88657111
31doxorubicin metabolic process (GO:0044598)3.88657111
32daunorubicin metabolic process (GO:0044597)3.88657111
33regulation of type B pancreatic cell apoptotic process (GO:2000674)3.87623837
34regulation of B cell differentiation (GO:0045577)3.86695474
35positive regulation of mast cell activation (GO:0033005)3.84890215
36response to peptidoglycan (GO:0032494)3.83558722
37B cell receptor signaling pathway (GO:0050853)3.83512122
38regulation of mast cell activation involved in immune response (GO:0033006)3.83357525
39leukocyte migration involved in inflammatory response (GO:0002523)3.80683053
40granulocyte activation (GO:0036230)3.78724554
41negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.78670472
42negative regulation of erythrocyte differentiation (GO:0045647)3.76081147
43negative regulation of leukocyte mediated immunity (GO:0002704)3.66166226
44negative regulation of T cell mediated immunity (GO:0002710)3.65864102
45cellular extravasation (GO:0045123)3.63622112
46regulation of mast cell activation (GO:0033003)3.61475633
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.61048209
48regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.57269796
49thrombin receptor signaling pathway (GO:0070493)3.57264747
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55473172
51sequestering of metal ion (GO:0051238)3.54957421
52retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52676738
53positive regulation of insulin secretion (GO:0032024)3.46297741
54myeloid cell activation involved in immune response (GO:0002275)3.46074418
55regulation of leukocyte degranulation (GO:0043300)3.44424281
56regulation of platelet aggregation (GO:0090330)3.41458710
57ribosomal small subunit assembly (GO:0000028)3.41319272
58megakaryocyte development (GO:0035855)3.40094672
59mast cell degranulation (GO:0043303)3.39073572
60mast cell activation involved in immune response (GO:0002279)3.39073572
61interferon-gamma production (GO:0032609)3.37052073
62response to muramyl dipeptide (GO:0032495)3.36728603
63endosome to melanosome transport (GO:0035646)3.35796440
64endosome to pigment granule transport (GO:0043485)3.35796440
65B cell mediated immunity (GO:0019724)3.32589774
66regulation of gamma-delta T cell differentiation (GO:0045586)3.32065181
67DNA deamination (GO:0045006)3.31778382
68negative regulation of T-helper cell differentiation (GO:0045623)3.28734628
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.28734628
70definitive hemopoiesis (GO:0060216)3.28304281
71positive regulation of mast cell activation involved in immune response (GO:0033008)3.26688115
72positive regulation of mast cell degranulation (GO:0043306)3.26688115
73microglial cell activation (GO:0001774)3.26194822
74macrophage activation involved in immune response (GO:0002281)3.23872250
75regulation of T cell mediated cytotoxicity (GO:0001914)3.18246154
76regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.16612282
77regulation of natural killer cell mediated immunity (GO:0002715)3.16612282
78protein autoprocessing (GO:0016540)3.16571801
79negative regulation of interleukin-12 production (GO:0032695)3.15817139
80response to host immune response (GO:0052572)3.15334714
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15334714
82regulation of T cell receptor signaling pathway (GO:0050856)3.12544309
83type B pancreatic cell development (GO:0003323)3.11414840
84positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.10797713
85regulation of alpha-beta T cell proliferation (GO:0046640)3.10046155
86positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09619407
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08725751
88germinal center formation (GO:0002467)3.08709072
89GDP-mannose metabolic process (GO:0019673)3.07866180
90negative regulation of glycoprotein metabolic process (GO:1903019)3.07710598
91detection of external biotic stimulus (GO:0098581)3.05640133
92mucosal-associated lymphoid tissue development (GO:0048537)3.04243139
93Peyers patch development (GO:0048541)3.04243139
94cotranslational protein targeting to membrane (GO:0006613)3.04038823
95negative regulation of phagocytosis (GO:0050765)3.02611650
96tolerance induction (GO:0002507)3.02468907
97regulation of gamma-delta T cell activation (GO:0046643)3.02133471
98Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01227174
99maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00602952
100respiratory burst (GO:0045730)3.00400289
101positive T cell selection (GO:0043368)3.00008866
102protein targeting to ER (GO:0045047)2.99746679
103platelet dense granule organization (GO:0060155)2.99084641
104glandular epithelial cell differentiation (GO:0002067)2.96592021
105glycoside metabolic process (GO:0016137)2.96205879
106T cell selection (GO:0045058)2.93200681
107regulation of regulated secretory pathway (GO:1903305)2.93183005
108negative regulation of innate immune response (GO:0045824)2.93058870
109leukocyte degranulation (GO:0043299)2.91340460
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90379077
111protein localization to endoplasmic reticulum (GO:0070972)2.89886329
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89710172
113T cell homeostasis (GO:0043029)2.88790391
114negative regulation of bone resorption (GO:0045779)2.87773353
115regulation of granulocyte differentiation (GO:0030852)2.87340251
116COPII vesicle coating (GO:0048208)2.86640844
117defense response to protozoan (GO:0042832)2.85536699
118glandular epithelial cell development (GO:0002068)2.85500677
119negative regulation of interleukin-6 production (GO:0032715)2.84969771
120thymic T cell selection (GO:0045061)2.84861884
121response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83678968
122response to host (GO:0075136)2.83678968
123response to host defenses (GO:0052200)2.83678968
124regulation of isotype switching to IgG isotypes (GO:0048302)2.83641460
125antigen receptor-mediated signaling pathway (GO:0050851)2.82801532
126protein retention in ER lumen (GO:0006621)2.82781607
127G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.82176953
128mannosylation (GO:0097502)2.81079589
129regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78434316
130regulation of leukocyte mediated cytotoxicity (GO:0001910)2.78000171
131activated T cell proliferation (GO:0050798)2.77036805
132fucose metabolic process (GO:0006004)2.76494207
133nucleoside diphosphate catabolic process (GO:0009134)2.75822151
134positive regulation of B cell differentiation (GO:0045579)2.73899088
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72780927
136positive regulation of peptide hormone secretion (GO:0090277)2.71810317
137T cell migration (GO:0072678)2.71250455
138macrophage activation (GO:0042116)2.71188866
139detection of biotic stimulus (GO:0009595)2.71185618
140response to interleukin-15 (GO:0070672)2.69655983
141leukocyte aggregation (GO:0070486)2.69326871
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68610636
143regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68291167
144astrocyte differentiation (GO:0048708)2.67428025
145lymph node development (GO:0048535)2.65457680
146negative regulation of calcium ion transport into cytosol (GO:0010523)2.63803841
147positive regulation of peptide secretion (GO:0002793)2.60889282
148negative regulation of execution phase of apoptosis (GO:1900118)2.60431173
149regulation of oxidative phosphorylation (GO:0002082)2.59120559
150insulin secretion (GO:0030073)2.58509884
151cellular response to interleukin-15 (GO:0071350)2.57155046
152intra-Golgi vesicle-mediated transport (GO:0006891)2.56769917
153natural killer cell activation involved in immune response (GO:0002323)2.56377167
154positive thymic T cell selection (GO:0045059)2.54685254
155regulation of insulin secretion (GO:0050796)2.54397959
156amyloid precursor protein metabolic process (GO:0042982)2.51822875
157respiratory chain complex IV assembly (GO:0008535)2.49323613
158regulation of B cell receptor signaling pathway (GO:0050855)2.48971178
159regulation of defense response to virus by virus (GO:0050690)2.47978492
160GPI anchor biosynthetic process (GO:0006506)2.47341089
161amyloid precursor protein catabolic process (GO:0042987)2.47264439
162negative T cell selection (GO:0043383)2.45430385
163positive regulation of granulocyte differentiation (GO:0030854)2.44302373
164lysosome localization (GO:0032418)2.44252366
165viral protein processing (GO:0019082)2.43682005
166lymphoid progenitor cell differentiation (GO:0002320)2.42631741
167negative regulation of T cell receptor signaling pathway (GO:0050860)2.42276423
168toxin transport (GO:1901998)2.39942330
169negative thymic T cell selection (GO:0045060)2.37811524
170negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.37615566
171regulation of regulatory T cell differentiation (GO:0045589)2.36818341
172regulation of axon regeneration (GO:0048679)2.36494396
173regulation of neuron projection regeneration (GO:0070570)2.36494396
174regulation of erythrocyte differentiation (GO:0045646)2.36354840
175regulation of peptide hormone secretion (GO:0090276)2.35121414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human3.94748997
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.92424122
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.67136450
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53219758
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48031415
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.43490112
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39855981
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38571809
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.33283105
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.10901948
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.01904401
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.87886975
13GATA1_22025678_ChIP-Seq_K562_Human2.80030840
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.65585192
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.64517537
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53910209
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.53408521
18MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.50721479
19ERG_20887958_ChIP-Seq_HPC-7_Mouse2.49450406
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.43952284
21SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.34087218
22* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.33306676
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.26921570
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24592214
25* MYB_26560356_Chip-Seq_TH2_Human2.11806888
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.10114150
27* SPI1_23547873_ChIP-Seq_NB4_Human2.09187299
28RUNX_20019798_ChIP-Seq_JUKART_Human2.07908121
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07392014
30GFI1B_20887958_ChIP-Seq_HPC-7_Mouse2.05641434
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01257715
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99660939
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97246658
34* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96364522
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94156552
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.91587327
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.88207965
38MYC_22102868_ChIP-Seq_BL_Human1.88195764
39VDR_23849224_ChIP-Seq_CD4+_Human1.85372977
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79500187
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.78288035
42* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77179101
43FOXP3_21729870_ChIP-Seq_TREG_Human1.74427960
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72757850
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.72519423
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.71530325
47CIITA_25753668_ChIP-Seq_RAJI_Human1.67152465
48GATA3_27048872_Chip-Seq_THYMUS_Human1.66690891
49* MYB_26560356_Chip-Seq_TH1_Human1.65619579
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.64890607
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60071184
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59609941
53SPI1_23127762_ChIP-Seq_K562_Human1.56532185
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52035480
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48347003
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47639046
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47592055
58* UTX_26944678_Chip-Seq_JUKART_Human1.47530695
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47510288
60* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47488574
61VDR_21846776_ChIP-Seq_THP-1_Human1.46106667
62GATA2_19941826_ChIP-Seq_K562_Human1.45779805
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44317283
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43677580
65* KDM2B_26808549_Chip-Seq_DND41_Human1.43355043
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.42405578
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39691901
68VDR_24787735_ChIP-Seq_THP-1_Human1.39606788
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39301551
70* VDR_24763502_ChIP-Seq_THP-1_Human1.38883154
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33947684
72* MAF_26560356_Chip-Seq_TH1_Human1.32669566
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30988988
74GABP_19822575_ChIP-Seq_HepG2_Human1.30877307
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30610073
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30392786
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.28877918
78* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28253278
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27370836
80* GATA3_26560356_Chip-Seq_TH2_Human1.24823164
81BCL6_27268052_Chip-Seq_Bcells_Human1.23058297
82ELK1_19687146_ChIP-ChIP_HELA_Human1.22419603
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21808775
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20881115
85* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20481929
86SPI1_20517297_ChIP-Seq_HL60_Human1.20008265
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19721940
88ETS1_22383799_ChIP-Seq_G1ME_Mouse1.19356663
89* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17806128
90GATA1_19941826_ChIP-Seq_K562_Human1.16280416
91TFEB_21752829_ChIP-Seq_HELA_Human1.15546794
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14823818
93* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13858528
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12784231
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12669020
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.12358595
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10755533
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09849267
99BCOR_27268052_Chip-Seq_Bcells_Human1.09264219
100IRF8_21731497_ChIP-ChIP_J774_Mouse1.08314395
101* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08269458
102NCOR1_26117541_ChIP-Seq_K562_Human1.03197320
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02568093
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.02286911
105* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01917679
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01895853
107* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00931640
108P300_27268052_Chip-Seq_Bcells_Human1.00507051
109IRF8_27001747_Chip-Seq_BMDM_Mouse0.98583833
110TCF7_22412390_ChIP-Seq_EML_Mouse0.97869051
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95869307
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95022262
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.93257891
114* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92222667
115LXR_22292898_ChIP-Seq_THP-1_Human0.91450097
116MAF_26560356_Chip-Seq_TH2_Human0.91025305
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90747522
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90154421
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89699483
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89275069
121GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88526607
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88125902
123* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87352920
124* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86774752
125E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85512880
126IGF1R_20145208_ChIP-Seq_DFB_Human0.83945238
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83617719
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83370791
129* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83217191
130* PU_27001747_Chip-Seq_BMDM_Mouse0.82721840
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.82167843
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79500412
133BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78066014
134* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77910741
135XRN2_22483619_ChIP-Seq_HELA_Human0.76952181
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75915669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.68214217
2MP0003303_peritoneal_inflammation3.49037821
3MP0005379_endocrine/exocrine_gland_phen3.37175380
4MP0002877_abnormal_melanocyte_morpholog3.15942525
5MP0001986_abnormal_taste_sensitivity3.15040873
6MP0005671_abnormal_response_to3.07406518
7MP0002693_abnormal_pancreas_physiology2.94520737
8MP0003763_abnormal_thymus_physiology2.85723744
9MP0000013_abnormal_adipose_tissue2.71217257
10MP0005645_abnormal_hypothalamus_physiol2.42940749
11MP0001835_abnormal_antigen_presentation2.42715898
12MP0001944_abnormal_pancreas_morphology2.37987743
13MP0003724_increased_susceptibility_to2.23934390
14MP0003866_abnormal_defecation2.20526934
15MP0005075_abnormal_melanosome_morpholog2.18873655
16MP0000685_abnormal_immune_system2.15104667
17MP0002909_abnormal_adrenal_gland2.15028518
18MP0004043_abnormal_pH_regulation2.09247628
19MP0003172_abnormal_lysosome_physiology2.08338340
20MP0005174_abnormal_tail_pigmentation2.04245788
21MP0009278_abnormal_bone_marrow1.99970915
22MP0010386_abnormal_urinary_bladder1.99288731
23MP0002396_abnormal_hematopoietic_system1.92043660
24MP0003191_abnormal_cellular_cholesterol1.90417365
25MP0001533_abnormal_skeleton_physiology1.88521343
26MP0005464_abnormal_platelet_physiology1.86817113
27MP0005000_abnormal_immune_tolerance1.84736990
28MP0005646_abnormal_pituitary_gland1.82899486
29MP0005387_immune_system_phenotype1.80648749
30MP0001790_abnormal_immune_system1.80648749
31MP0000465_gastrointestinal_hemorrhage1.80477451
32MP0000678_abnormal_parathyroid_gland1.78898464
33MP0002420_abnormal_adaptive_immunity1.78534016
34MP0002723_abnormal_immune_serum1.78192941
35MP0002398_abnormal_bone_marrow1.77765659
36MP0001819_abnormal_immune_cell1.74921470
37MP0005220_abnormal_exocrine_pancreas1.74165030
38MP0003828_pulmonary_edema1.72281785
39MP0009785_altered_susceptibility_to1.71286663
40MP0008004_abnormal_stomach_pH1.70317876
41MP0001800_abnormal_humoral_immune1.69206026
42MP0001851_eye_inflammation1.69183640
43MP0002163_abnormal_gland_morphology1.65012297
44MP0002638_abnormal_pupillary_reflex1.63834249
45MP0003195_calcinosis1.60058739
46MP0006292_abnormal_olfactory_placode1.59417791
47MP0005025_abnormal_response_to1.57959792
48MP0000716_abnormal_immune_system1.53221983
49MP0002148_abnormal_hypersensitivity_rea1.50628069
50MP0009764_decreased_sensitivity_to1.50333403
51MP0002095_abnormal_skin_pigmentation1.49385408
52MP0002452_abnormal_antigen_presenting1.44893842
53MP0005310_abnormal_salivary_gland1.42793225
54MP0003283_abnormal_digestive_organ1.40106794
55MP0000015_abnormal_ear_pigmentation1.38576276
56MP0001188_hyperpigmentation1.36073814
57MP0000003_abnormal_adipose_tissue1.36000411
58MP0000703_abnormal_thymus_morphology1.31893625
59MP0002429_abnormal_blood_cell1.30566333
60MP0003300_gastrointestinal_ulcer1.30063972
61MP0009333_abnormal_splenocyte_physiolog1.29998493
62MP0002419_abnormal_innate_immunity1.29412183
63MP0005058_abnormal_lysosome_morphology1.29283977
64MP0002078_abnormal_glucose_homeostasis1.29034641
65MP0001765_abnormal_ion_homeostasis1.26037508
66MP0002722_abnormal_immune_system1.25489695
67MP0002928_abnormal_bile_duct1.24007020
68MP0000689_abnormal_spleen_morphology1.21290422
69MP0004381_abnormal_hair_follicle1.18961774
70MP0004808_abnormal_hematopoietic_stem1.18711761
71MP0004147_increased_porphyrin_level1.16158574
72MP0002405_respiratory_system_inflammati1.13861519
73MP0010155_abnormal_intestine_physiology1.13849662
74MP0001845_abnormal_inflammatory_respons1.10870925
75MP0001545_abnormal_hematopoietic_system1.10004227
76MP0005397_hematopoietic_system_phenotyp1.10004227
77MP0002166_altered_tumor_susceptibility1.09750252
78MP0003075_altered_response_to1.08143225
79MP0003656_abnormal_erythrocyte_physiolo1.07291328
80MP0003959_abnormal_lean_body1.06763793
81MP0006054_spinal_hemorrhage1.06226637
82MP0008260_abnormal_autophagy1.04786857
83MP0009763_increased_sensitivity_to1.04776721
84MP0002837_dystrophic_cardiac_calcinosis1.04687652
85MP0000858_altered_metastatic_potential1.04168533
86MP0001873_stomach_inflammation1.03684363
87MP0000372_irregular_coat_pigmentation1.02414674
88MP0002938_white_spotting1.01925846
89MP0002933_joint_inflammation1.01647115
90MP0003868_abnormal_feces_composition1.01222785
91MP0006072_abnormal_retinal_apoptosis1.00898989
92MP0005636_abnormal_mineral_homeostasis1.00113374
93MP0003436_decreased_susceptibility_to0.98667677
94MP0001663_abnormal_digestive_system0.98552846
95MP0009765_abnormal_xenobiotic_induced0.97770648
96MP0001502_abnormal_circadian_rhythm0.97506583
97MP0002998_abnormal_bone_remodeling0.94625069
98MP0000613_abnormal_salivary_gland0.94234203
99MP0006082_CNS_inflammation0.91561254
100MP0001348_abnormal_lacrimal_gland0.90725767
101MP0000343_altered_response_to0.90170037
102MP0005409_darkened_coat_color0.89883361
103MP0000490_abnormal_crypts_of0.89838552
104MP0009780_abnormal_chondrocyte_physiolo0.88292137
105MP0003638_abnormal_response/metabolism_0.85249368
106MP0003943_abnormal_hepatobiliary_system0.84598495
107MP0004510_myositis0.83685972
108MP0000681_abnormal_thyroid_gland0.83230579
109MP0004130_abnormal_muscle_cell0.83210641
110MP0008469_abnormal_protein_level0.82134595
111MP0004883_abnormal_blood_vessel0.82046039
112MP0005084_abnormal_gallbladder_morpholo0.82037961
113MP0005083_abnormal_biliary_tract0.81923555
114MP0008961_abnormal_basal_metabolism0.78923365
115MP0002132_abnormal_respiratory_system0.77825051
116MP0004947_skin_inflammation0.77544298
117MP0003122_maternal_imprinting0.77410244
118MP0005390_skeleton_phenotype0.76782014
119MP0002019_abnormal_tumor_incidence0.76457832
120MP0003953_abnormal_hormone_level0.76402969
121MP0009643_abnormal_urine_homeostasis0.76267307
122MP0000249_abnormal_blood_vessel0.74667399
123MP0003252_abnormal_bile_duct0.74423624
124MP0005166_decreased_susceptibility_to0.73654664
125MP0003806_abnormal_nucleotide_metabolis0.72838061
126MP0003879_abnormal_hair_cell0.72460702
127MP0004264_abnormal_extraembryonic_tissu0.69440687
128MP0001270_distended_abdomen0.69225633
129MP0008874_decreased_physiological_sensi0.68996027
130MP0001853_heart_inflammation0.68314615
131MP0002277_abnormal_respiratory_mucosa0.67495153
132MP0005535_abnormal_body_temperature0.64780254
133MP0002009_preneoplasia0.64238718
134MP0008872_abnormal_physiological_respon0.59536949
135MP0005164_abnormal_response_to0.59206905
136MP0000230_abnormal_systemic_arterial0.58676709
137MP0009642_abnormal_blood_homeostasis0.57101592
138MP0002006_tumorigenesis0.55642394
139MP0008873_increased_physiological_sensi0.54321358
140MP0003787_abnormal_imprinting0.53969874
141MP0003795_abnormal_bone_structure0.53368840
142MP0004484_altered_response_of0.51719349
143MP0005165_increased_susceptibility_to0.50872986
144MP0003045_fibrosis0.50137990

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.16663284
2Eczematoid dermatitis (HP:0000976)5.08919114
3Hypoglycemic seizures (HP:0002173)4.64261632
4Abnormal platelet volume (HP:0011876)4.55031710
5Orchitis (HP:0100796)4.47981722
6Recurrent bacterial skin infections (HP:0005406)4.46956982
7Gingival bleeding (HP:0000225)4.46496953
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.46108772
9Hyperinsulinemic hypoglycemia (HP:0000825)4.40767842
10Purpura (HP:0000979)4.29650126
11Symptomatic seizures (HP:0011145)4.29542309
12Retrobulbar optic neuritis (HP:0100654)4.24253516
13Optic neuritis (HP:0100653)4.24253516
14Menorrhagia (HP:0000132)4.18079683
15Abnormality of macrophages (HP:0004311)4.14773672
16Increased mean platelet volume (HP:0011877)4.04492336
17Encephalitis (HP:0002383)3.97746291
18Aplastic anemia (HP:0001915)3.95109981
19Spontaneous hematomas (HP:0007420)3.92129539
20Obstructive lung disease (HP:0006536)3.80125522
21Chronic obstructive pulmonary disease (HP:0006510)3.80125522
22Chronic otitis media (HP:0000389)3.79026831
23Hypothermia (HP:0002045)3.73608505
24Hypoglycemic coma (HP:0001325)3.60803397
25Type I transferrin isoform profile (HP:0003642)3.52267710
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.44877188
27Abnormal platelet function (HP:0011869)3.41302469
28Impaired platelet aggregation (HP:0003540)3.41302469
29Abnormality of calcium-phosphate metabolism (HP:0100530)3.40007202
30Abnormal glycosylation (HP:0012345)3.31971480
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.31971480
32Abnormal protein N-linked glycosylation (HP:0012347)3.31971480
33Abnormal protein glycosylation (HP:0012346)3.31971480
34Petechiae (HP:0000967)3.25236036
35Recurrent gram-negative bacterial infections (HP:0005420)3.22895644
36IgM deficiency (HP:0002850)3.21677497
37Recurrent skin infections (HP:0001581)3.19660128
38Gastrointestinal infarctions (HP:0005244)3.19648593
39Granulocytopenia (HP:0001913)3.19409101
40Mediastinal lymphadenopathy (HP:0100721)3.18967840
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.17691180
42Chest pain (HP:0100749)3.15034763
43Leukocytosis (HP:0001974)3.12876785
44Keratoconjunctivitis sicca (HP:0001097)3.09794428
45Large for gestational age (HP:0001520)3.09326605
46Late onset (HP:0003584)3.08594311
47Increased IgE level (HP:0003212)3.08459579
48Abnormality of endocrine pancreas physiology (HP:0012093)3.07006185
49Abnormality of the pancreatic islet cells (HP:0006476)3.07006185
50Vasculitis (HP:0002633)3.03500909
51Agammaglobulinemia (HP:0004432)2.97129731
52Decreased circulating renin level (HP:0003351)2.94142212
53Arterial thrombosis (HP:0004420)2.90722370
54Increased IgM level (HP:0003496)2.90558483
55Inflammation of the large intestine (HP:0002037)2.90457045
56Keratoconjunctivitis (HP:0001096)2.90379155
57Recurrent bronchitis (HP:0002837)2.90336850
58Dysostosis multiplex (HP:0000943)2.89493473
59Progressive neurologic deterioration (HP:0002344)2.87899358
60Abnormality of T cell physiology (HP:0011840)2.85994643
61Gastrointestinal inflammation (HP:0004386)2.82918756
62Pancreatic islet-cell hyperplasia (HP:0004510)2.80701178
63Urticaria (HP:0001025)2.79457258
64Cellulitis (HP:0100658)2.78300379
65Prolonged bleeding time (HP:0003010)2.76895105
66Hypochromic microcytic anemia (HP:0004840)2.76248772
67Elevated erythrocyte sedimentation rate (HP:0003565)2.73514733
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.67893475
69Insulin-resistant diabetes mellitus (HP:0000831)2.66743945
70Abnormality of T cells (HP:0002843)2.66551595
71Pulmonary infiltrates (HP:0002113)2.64199439
72Severe combined immunodeficiency (HP:0004430)2.62156569
73Hypochromic anemia (HP:0001931)2.60657961
74Pustule (HP:0200039)2.57139955
75Mucopolysacchariduria (HP:0008155)2.56481217
76Urinary glycosaminoglycan excretion (HP:0003541)2.56481217
77Generalized aminoaciduria (HP:0002909)2.55387267
78Pulmonary embolism (HP:0002204)2.52315807
7911 pairs of ribs (HP:0000878)2.51765041
80Hemoptysis (HP:0002105)2.51014404
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49852227
82Hypoplasia of the thymus (HP:0000778)2.49043155
83Eosinophilia (HP:0001880)2.48977290
84Panhypogammaglobulinemia (HP:0003139)2.48890680
85Reduced antithrombin III activity (HP:0001976)2.46734919
86Abnormality of iron homeostasis (HP:0011031)2.46012023
87T lymphocytopenia (HP:0005403)2.44107099
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43548119
89Abnormality of polysaccharide metabolism (HP:0011012)2.43548119
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43548119
91Abnormality of the heme biosynthetic pathway (HP:0010472)2.43269657
92Thrombocytosis (HP:0001894)2.42928247
93Hepatosplenomegaly (HP:0001433)2.38969311
94Abnormality of eosinophils (HP:0001879)2.38499146
95Ketoacidosis (HP:0001993)2.36764542
96Increased serum ferritin (HP:0003281)2.33662858
97Gingivitis (HP:0000230)2.33270241
98Vacuolated lymphocytes (HP:0001922)2.32011871
99Menstrual irregularities (HP:0000858)2.31532900
100Hyperlipoproteinemia (HP:0010980)2.31357472
101Vertigo (HP:0002321)2.30863938
102Abnormality of T cell number (HP:0011839)2.25983888
103Prominent metopic ridge (HP:0005487)2.25730357
104Acute hepatic failure (HP:0006554)2.25489284
105Bruising susceptibility (HP:0000978)2.25483722
106Hypergammaglobulinemia (HP:0010702)2.25070663
107Agitation (HP:0000713)2.23786569
108Broad face (HP:0000283)2.22707332
109Neuroendocrine neoplasm (HP:0100634)2.22689914
110Microcytic anemia (HP:0001935)2.20282573
111Colitis (HP:0002583)2.20274238
112Recurrent viral infections (HP:0004429)2.20138543
113Recurrent fungal infections (HP:0002841)2.18514355
114Anorexia (HP:0002039)2.17814512
115Hyperglycemia (HP:0003074)2.17800061
116Retinal atrophy (HP:0001105)2.16863098
117Abnormality of the prostate (HP:0008775)2.15642755
118Myositis (HP:0100614)2.15534407
119Abnormality of transition element cation homeostasis (HP:0011030)2.14856086
120Increased cerebral lipofuscin (HP:0011813)2.14476561
121Sepsis (HP:0100806)2.13595137
122Bronchitis (HP:0012387)2.11880169
123Joint swelling (HP:0001386)2.10370311
124Papilledema (HP:0001085)2.10347174
125Type II lissencephaly (HP:0007260)2.10295068
126Chronic sinusitis (HP:0011109)2.09057192
127Osteomyelitis (HP:0002754)2.08869983
128Nasal polyposis (HP:0100582)2.06844196
129Abnormality of the pleura (HP:0002103)2.06454270
130Stomach cancer (HP:0012126)2.05443004
131Abnormality of B cell number (HP:0010975)2.04807199
132Abnormal pupillary function (HP:0007686)2.03131961
133Epistaxis (HP:0000421)2.02570237
134IgG deficiency (HP:0004315)2.02010136
135Gangrene (HP:0100758)2.01106609
136Episodic fever (HP:0001954)1.98934322
137Patchy hypopigmentation of hair (HP:0011365)1.98577820
138Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98384555
139Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98384555
140Unilateral renal agenesis (HP:0000122)1.97815993
141Cortical visual impairment (HP:0100704)1.97627488
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.96223549
143Hypoplasia of the fovea (HP:0007750)1.96223549
144Thrombophlebitis (HP:0004418)1.94273463
145Autoimmune thrombocytopenia (HP:0001973)1.93705909
146Neutropenia (HP:0001875)1.93125605
147Amyloidosis (HP:0011034)1.92677031
148Abnormality of renin-angiotensin system (HP:0000847)1.92251033
149Limb hypertonia (HP:0002509)1.91283980
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90998216
151Skin rash (HP:0000988)1.89916954
152Combined immunodeficiency (HP:0005387)1.88979964
153Glomerulopathy (HP:0100820)1.88087679
154Type 2 muscle fiber atrophy (HP:0003554)1.87558518
155Autoimmune hemolytic anemia (HP:0001890)1.86889097
156Hyperphosphatemia (HP:0002905)1.86821113
157Retinal dysplasia (HP:0007973)1.86602674
158Viral hepatitis (HP:0006562)1.85942397
159Spinal canal stenosis (HP:0003416)1.85010844
160Insulin resistance (HP:0000855)1.84530029
161Abnormal rod and cone electroretinograms (HP:0008323)1.84145360
162Recurrent abscess formation (HP:0002722)1.82988488
163Abnormal number of erythroid precursors (HP:0012131)1.82263329
164Recurrent cutaneous fungal infections (HP:0011370)1.81934569
165Chronic mucocutaneous candidiasis (HP:0002728)1.81934569
166Pheochromocytoma (HP:0002666)1.81609497
167Chronic diarrhea (HP:0002028)1.80290437
168White forelock (HP:0002211)1.80226081
169Abnormality of the nasal mucosa (HP:0000433)1.79328088
170Abnormality of dental color (HP:0011073)1.78482953
171Meningitis (HP:0001287)1.78423744
172Microvesicular hepatic steatosis (HP:0001414)1.77851262
173Lymphopenia (HP:0001888)1.77036590
174Hepatic necrosis (HP:0002605)1.76405738
175Abnormality of the metopic suture (HP:0005556)1.75081719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.69310843
2MAPK154.28597793
3INSRR4.14374674
4PASK3.89913192
5STK163.45606515
6TXK3.26743485
7GRK63.05545177
8MAP4K12.90731128
9TAOK32.68288027
10FLT32.65030269
11TNIK2.28788854
12HIPK22.24222757
13TEC2.21369972
14KIT2.19262553
15ZAP702.16341479
16WNK32.07244230
17BTK2.05744332
18JAK32.00951723
19PRPF4B1.77656794
20PIK3CG1.72592760
21MAP3K121.63638201
22SIK31.60763145
23ITK1.60288992
24NLK1.58262291
25MAP3K111.55788597
26MAPKAPK51.54179431
27CAMKK21.47631535
28IKBKE1.36751572
29SYK1.33035861
30ADRBK21.32969933
31EPHA31.30682518
32MUSK1.28266575
33NME21.28035929
34CDK191.24495139
35FGR1.21764490
36IRAK41.19776553
37UHMK11.18612144
38TBK11.12210733
39SCYL21.11725331
40BMX1.10974508
41MAP3K31.09451242
42LCK1.08157666
43TAOK11.00395177
44IRAK10.98469788
45VRK10.98189057
46IRAK30.97636297
47PRKCQ0.97520233
48PTK2B0.96758551
49WNK40.95307486
50EPHB10.95158058
51DYRK30.95073347
52FGFR40.94981577
53MAP3K130.92600852
54TYK20.91557224
55BRSK20.91387091
56KDR0.90996388
57PIM20.90750764
58PDK10.89177244
59CDK80.89148352
60SIK20.88659931
61STK100.84147310
62MAP3K10.81462447
63LYN0.79568240
64MAPK120.78863749
65MAPKAPK30.76874936
66JAK10.76616198
67TESK20.76598059
68TLK10.76211596
69TGFBR10.75375806
70PIM10.74437599
71BLK0.73750249
72MATK0.71504771
73DAPK20.71045723
74EIF2AK30.70141617
75BMPR1B0.69512798
76EEF2K0.68686062
77TAOK20.68390585
78IKBKB0.67781660
79PRKG20.67734805
80MAP4K20.66027827
81FYN0.65998292
82PRKD20.65906213
83LRRK20.65341951
84PRKCH0.64676067
85MARK20.64311706
86MAP2K70.62327940
87PDPK10.59725349
88GRK50.59022900
89RPS6KA50.57829840
90FES0.57314633
91TIE10.56866729
92BCKDK0.56443700
93YES10.55376063
94CSF1R0.54943708
95CSK0.53740202
96CAMKK10.52345683
97MARK30.51284544
98IRAK20.49809913
99MAP2K30.48826999
100JAK20.47891561
101MAP3K70.46572292
102DYRK1B0.46160596
103MAP3K140.45978371
104DAPK10.44202954
105HCK0.43298582
106RET0.43064590
107ERN10.41693298
108MAP3K60.41659348
109MAPK70.41470937
110MAP3K50.41153088
111TNK20.40878444
112MAP2K20.39748939
113CAMK10.39593651
114MAP3K20.39275772
115CHUK0.35783331
116NEK60.35527814
117MAPK110.34396298
118PRKCD0.34265982
119MAPK30.33986360
120MAP2K60.33224796
121MAPK130.33125229
122PRKD30.32889642
123BMPR20.32884390
124FRK0.32182173
125PRKD10.31383150
126MAPKAPK20.31375527
127STK110.30323435
128FGFR30.30035393
129TGFBR20.29950017
130RPS6KA60.29878930
131CDK40.28013823
132ADRBK10.27889572
133ACVR1B0.27859927
134NUAK10.27280603
135RPS6KL10.26802811
136RPS6KC10.26802811
137ABL10.26781226
138IGF1R0.26321286
139MAP2K40.26233634
140RPS6KB10.25775641
141CLK10.25721642
142WNK10.25169533
143KSR20.22926824
144RAF10.20359459

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.67012700
2Protein export_Homo sapiens_hsa030605.26246295
3Primary immunodeficiency_Homo sapiens_hsa053402.79883752
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.54964806
5Staphylococcus aureus infection_Homo sapiens_hsa051502.33169554
6Other glycan degradation_Homo sapiens_hsa005112.08673267
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01891303
8Type I diabetes mellitus_Homo sapiens_hsa049401.99189489
9Insulin secretion_Homo sapiens_hsa049111.87064026
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84854649
11N-Glycan biosynthesis_Homo sapiens_hsa005101.77038887
12Tuberculosis_Homo sapiens_hsa051521.70793619
13Hematopoietic cell lineage_Homo sapiens_hsa046401.65058034
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63853977
15Regulation of autophagy_Homo sapiens_hsa041401.63687140
16Antigen processing and presentation_Homo sapiens_hsa046121.55743527
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54547859
18Ribosome_Homo sapiens_hsa030101.54139965
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50949030
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50384037
21Viral myocarditis_Homo sapiens_hsa054161.45902967
22Sulfur metabolism_Homo sapiens_hsa009201.45663632
23Malaria_Homo sapiens_hsa051441.39199152
24Measles_Homo sapiens_hsa051621.34107593
25T cell receptor signaling pathway_Homo sapiens_hsa046601.30936169
26Folate biosynthesis_Homo sapiens_hsa007901.26878045
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.26770688
28Lysosome_Homo sapiens_hsa041421.26025404
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24884579
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.22261550
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19415153
32Non-small cell lung cancer_Homo sapiens_hsa052231.18136601
33Vibrio cholerae infection_Homo sapiens_hsa051101.17063414
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.13343460
35Asthma_Homo sapiens_hsa053101.10143316
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.09745919
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06794381
38Circadian rhythm_Homo sapiens_hsa047101.05681959
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.03754855
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02768817
41Allograft rejection_Homo sapiens_hsa053301.01419415
42TNF signaling pathway_Homo sapiens_hsa046681.00286482
43Phagosome_Homo sapiens_hsa041450.97059208
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96904252
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96604068
46Systemic lupus erythematosus_Homo sapiens_hsa053220.92560935
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91214276
48Cocaine addiction_Homo sapiens_hsa050300.90287923
49Homologous recombination_Homo sapiens_hsa034400.90078306
50Type II diabetes mellitus_Homo sapiens_hsa049300.88964194
51Pancreatic cancer_Homo sapiens_hsa052120.88246050
52African trypanosomiasis_Homo sapiens_hsa051430.87525504
53ABC transporters_Homo sapiens_hsa020100.87465697
54Non-homologous end-joining_Homo sapiens_hsa034500.86563002
55B cell receptor signaling pathway_Homo sapiens_hsa046620.86147273
56Leishmaniasis_Homo sapiens_hsa051400.85704409
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84531418
58Arachidonic acid metabolism_Homo sapiens_hsa005900.84331485
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81089285
60Apoptosis_Homo sapiens_hsa042100.80864874
61Endocytosis_Homo sapiens_hsa041440.80564442
62Sphingolipid metabolism_Homo sapiens_hsa006000.79710956
63Legionellosis_Homo sapiens_hsa051340.79470256
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77800902
65Fatty acid elongation_Homo sapiens_hsa000620.76747813
66Prolactin signaling pathway_Homo sapiens_hsa049170.75835951
67Acute myeloid leukemia_Homo sapiens_hsa052210.75765467
68Viral carcinogenesis_Homo sapiens_hsa052030.75601873
69Chronic myeloid leukemia_Homo sapiens_hsa052200.75014974
70Herpes simplex infection_Homo sapiens_hsa051680.74660196
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.74575454
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73378828
73Platelet activation_Homo sapiens_hsa046110.73313322
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.73280026
75RNA polymerase_Homo sapiens_hsa030200.72872160
76DNA replication_Homo sapiens_hsa030300.72534638
77Mismatch repair_Homo sapiens_hsa034300.71768792
78Selenocompound metabolism_Homo sapiens_hsa004500.71296510
79Taste transduction_Homo sapiens_hsa047420.71241206
80Pyrimidine metabolism_Homo sapiens_hsa002400.71199618
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69944529
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68103888
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68077943
84Hepatitis C_Homo sapiens_hsa051600.67245085
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67208222
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65872369
87VEGF signaling pathway_Homo sapiens_hsa043700.64334048
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64178724
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60732935
90Osteoclast differentiation_Homo sapiens_hsa043800.60633764
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60211839
92Salmonella infection_Homo sapiens_hsa051320.58845680
93RNA degradation_Homo sapiens_hsa030180.58616166
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58478787
95Choline metabolism in cancer_Homo sapiens_hsa052310.58266893
96Chemokine signaling pathway_Homo sapiens_hsa040620.57757424
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.57663468
98Pancreatic secretion_Homo sapiens_hsa049720.57523434
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56032473
100Serotonergic synapse_Homo sapiens_hsa047260.55921020
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55817847
102Purine metabolism_Homo sapiens_hsa002300.55071582
103Autoimmune thyroid disease_Homo sapiens_hsa053200.53414896
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.51819892
105Graft-versus-host disease_Homo sapiens_hsa053320.50315066
106Ether lipid metabolism_Homo sapiens_hsa005650.49696025
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48067512
108Spliceosome_Homo sapiens_hsa030400.47828893
109Hepatitis B_Homo sapiens_hsa051610.47812744
110HTLV-I infection_Homo sapiens_hsa051660.46883976
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46657142
112Alcoholism_Homo sapiens_hsa050340.46395570
113Rheumatoid arthritis_Homo sapiens_hsa053230.44564132
114Base excision repair_Homo sapiens_hsa034100.44049970
115Shigellosis_Homo sapiens_hsa051310.43200553
116Olfactory transduction_Homo sapiens_hsa047400.42552378
117Thyroid cancer_Homo sapiens_hsa052160.42242891
118Basal transcription factors_Homo sapiens_hsa030220.40893892
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.40762776
120FoxO signaling pathway_Homo sapiens_hsa040680.40327052
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40211272
122MAPK signaling pathway_Homo sapiens_hsa040100.37951815
123Proteasome_Homo sapiens_hsa030500.37436274
124Pertussis_Homo sapiens_hsa051330.37305038
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36702312
126Dorso-ventral axis formation_Homo sapiens_hsa043200.36155074
127Inositol phosphate metabolism_Homo sapiens_hsa005620.34855796
128Renin secretion_Homo sapiens_hsa049240.34835032
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34047255
130Glycerolipid metabolism_Homo sapiens_hsa005610.34027240
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33926895
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33466923
133Galactose metabolism_Homo sapiens_hsa000520.33076871
134Amphetamine addiction_Homo sapiens_hsa050310.32288985
135GnRH signaling pathway_Homo sapiens_hsa049120.31886700
136Influenza A_Homo sapiens_hsa051640.31563497
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31217991
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30148571
139Rap1 signaling pathway_Homo sapiens_hsa040150.29473196
140Insulin resistance_Homo sapiens_hsa049310.29288523
141Circadian entrainment_Homo sapiens_hsa047130.29167321
142Epstein-Barr virus infection_Homo sapiens_hsa051690.29014570
143Toxoplasmosis_Homo sapiens_hsa051450.27696885
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27608514
145Calcium signaling pathway_Homo sapiens_hsa040200.27169285
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25560715
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.25500790

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