

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * synaptic vesicle exocytosis (GO:0016079) | 5.53283137 |
| 2 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.51221508 |
| 3 | * regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.50808526 |
| 4 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.27336327 |
| 5 | vocalization behavior (GO:0071625) | 5.26866253 |
| 6 | locomotory exploration behavior (GO:0035641) | 5.26440477 |
| 7 | * synaptic vesicle maturation (GO:0016188) | 5.18681474 |
| 8 | * glutamate secretion (GO:0014047) | 5.12226180 |
| 9 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.08893116 |
| 10 | * regulation of synaptic vesicle exocytosis (GO:2000300) | 4.91600401 |
| 11 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.86796128 |
| 12 | protein localization to synapse (GO:0035418) | 4.82490220 |
| 13 | neuronal action potential propagation (GO:0019227) | 4.80201584 |
| 14 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.72858665 |
| 15 | * neurotransmitter secretion (GO:0007269) | 4.57256326 |
| 16 | neuron cell-cell adhesion (GO:0007158) | 4.53378475 |
| 17 | * regulation of synaptic vesicle transport (GO:1902803) | 4.37705502 |
| 18 | exploration behavior (GO:0035640) | 4.30729312 |
| 19 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.29693898 |
| 20 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.18468219 |
| 21 | L-amino acid import (GO:0043092) | 4.12189307 |
| 22 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.08547373 |
| 23 | * regulation of neuronal synaptic plasticity (GO:0048168) | 4.03666956 |
| 24 | synaptic transmission, glutamatergic (GO:0035249) | 3.99967901 |
| 25 | regulation of synapse structural plasticity (GO:0051823) | 3.97138127 |
| 26 | layer formation in cerebral cortex (GO:0021819) | 3.96791042 |
| 27 | positive regulation of dendritic spine development (GO:0060999) | 3.92956810 |
| 28 | glutamate receptor signaling pathway (GO:0007215) | 3.92834617 |
| 29 | neuron-neuron synaptic transmission (GO:0007270) | 3.91718871 |
| 30 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.91608591 |
| 31 | potassium ion homeostasis (GO:0055075) | 3.91058228 |
| 32 | cellular potassium ion homeostasis (GO:0030007) | 3.87593679 |
| 33 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.86865853 |
| 34 | amino acid import (GO:0043090) | 3.85034882 |
| 35 | gamma-aminobutyric acid transport (GO:0015812) | 3.83771704 |
| 36 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.78452706 |
| 37 | regulation of synapse maturation (GO:0090128) | 3.77358300 |
| 38 | * neurotransmitter transport (GO:0006836) | 3.74448306 |
| 39 | positive regulation of membrane potential (GO:0045838) | 3.65128199 |
| 40 | neuromuscular process controlling posture (GO:0050884) | 3.64943952 |
| 41 | potassium ion import (GO:0010107) | 3.64736938 |
| 42 | proline transport (GO:0015824) | 3.62773073 |
| 43 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.61645336 |
| 44 | long-term memory (GO:0007616) | 3.61520290 |
| 45 | positive regulation of synapse maturation (GO:0090129) | 3.60744986 |
| 46 | synaptic vesicle endocytosis (GO:0048488) | 3.59152563 |
| 47 | activation of protein kinase A activity (GO:0034199) | 3.57785790 |
| 48 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.56836409 |
| 49 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.53151511 |
| 50 | cellular sodium ion homeostasis (GO:0006883) | 3.52672205 |
| 51 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.52574768 |
| 52 | establishment of mitochondrion localization (GO:0051654) | 3.52416035 |
| 53 | sodium ion export (GO:0071436) | 3.49782179 |
| 54 | dendritic spine organization (GO:0097061) | 3.49746989 |
| 55 | regulation of postsynaptic membrane potential (GO:0060078) | 3.48751368 |
| 56 | dendritic spine morphogenesis (GO:0060997) | 3.48385368 |
| 57 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.47936763 |
| 58 | * regulation of neurotransmitter levels (GO:0001505) | 3.45707690 |
| 59 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.45531618 |
| 60 | regulation of dendritic spine development (GO:0060998) | 3.41528976 |
| 61 | neuron recognition (GO:0008038) | 3.41308254 |
| 62 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.39794353 |
| 63 | long-term synaptic potentiation (GO:0060291) | 3.35855489 |
| 64 | * regulation of neurotransmitter secretion (GO:0046928) | 3.35151467 |
| 65 | * regulation of synaptic plasticity (GO:0048167) | 3.34501359 |
| 66 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.34332449 |
| 67 | transmission of nerve impulse (GO:0019226) | 3.33243295 |
| 68 | regulation of ARF protein signal transduction (GO:0032012) | 3.32662297 |
| 69 | axon ensheathment in central nervous system (GO:0032291) | 3.31137599 |
| 70 | central nervous system myelination (GO:0022010) | 3.31137599 |
| 71 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.29705964 |
| 72 | cell communication by electrical coupling (GO:0010644) | 3.27569998 |
| 73 | postsynaptic membrane organization (GO:0001941) | 3.27343009 |
| 74 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.23915422 |
| 75 | cerebellar Purkinje cell layer development (GO:0021680) | 3.23235411 |
| 76 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.21503451 |
| 77 | membrane depolarization during action potential (GO:0086010) | 3.20054018 |
| 78 | neuromuscular process controlling balance (GO:0050885) | 3.19403212 |
| 79 | acidic amino acid transport (GO:0015800) | 3.19143995 |
| 80 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.17439473 |
| 81 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.16478075 |
| 82 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.15072858 |
| 83 | auditory behavior (GO:0031223) | 3.13197835 |
| 84 | * regulation of neurotransmitter transport (GO:0051588) | 3.12193835 |
| 85 | positive regulation of neurotransmitter transport (GO:0051590) | 3.11991726 |
| 86 | membrane depolarization (GO:0051899) | 3.11059982 |
| 87 | membrane hyperpolarization (GO:0060081) | 3.10709380 |
| 88 | response to auditory stimulus (GO:0010996) | 3.10404315 |
| 89 | * establishment of synaptic vesicle localization (GO:0097480) | 3.09602190 |
| 90 | * synaptic vesicle transport (GO:0048489) | 3.09602190 |
| 91 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.09587371 |
| 92 | cell differentiation in hindbrain (GO:0021533) | 3.09325878 |
| 93 | vesicle docking involved in exocytosis (GO:0006904) | 3.07277811 |
| 94 | presynaptic membrane assembly (GO:0097105) | 3.07222550 |
| 95 | innervation (GO:0060384) | 3.06136421 |
| 96 | vesicle transport along microtubule (GO:0047496) | 3.04807405 |
| 97 | cell migration in hindbrain (GO:0021535) | 3.04698299 |
| 98 | cell communication involved in cardiac conduction (GO:0086065) | 3.04189168 |
| 99 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.03767783 |
| 100 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.03272812 |
| 101 | * synaptic transmission (GO:0007268) | 3.03149828 |
| 102 | glycine transport (GO:0015816) | 3.01569523 |
| 103 | prepulse inhibition (GO:0060134) | 3.01134135 |
| 104 | axonal fasciculation (GO:0007413) | 3.00797461 |
| 105 | synapse assembly (GO:0007416) | 2.98944868 |
| 106 | positive regulation of synaptic transmission (GO:0050806) | 2.97723295 |
| 107 | cerebellar granule cell differentiation (GO:0021707) | 2.96336855 |
| 108 | mating behavior (GO:0007617) | 2.95267140 |
| 109 | presynaptic membrane organization (GO:0097090) | 2.94863685 |
| 110 | learning (GO:0007612) | 2.93735085 |
| 111 | * regulation of synaptic transmission (GO:0050804) | 2.93464196 |
| 112 | adult walking behavior (GO:0007628) | 2.92532460 |
| 113 | neuronal ion channel clustering (GO:0045161) | 2.92303282 |
| 114 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.92124216 |
| 115 | * regulation of vesicle fusion (GO:0031338) | 2.92030920 |
| 116 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.91873695 |
| 117 | dendrite morphogenesis (GO:0048813) | 2.91702596 |
| 118 | behavioral response to cocaine (GO:0048148) | 2.89338999 |
| 119 | response to pheromone (GO:0019236) | 2.89252184 |
| 120 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.88943114 |
| 121 | neuromuscular process (GO:0050905) | 2.88472727 |
| 122 | negative regulation of microtubule polymerization (GO:0031115) | 2.86503005 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.00050007 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.52739566 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.23632119 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.14424036 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.10586497 |
| 6 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.93729393 |
| 7 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.75507898 |
| 8 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.73898507 |
| 9 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.73898507 |
| 10 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.65743859 |
| 11 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.63106411 |
| 12 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.62349125 |
| 13 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.59822508 |
| 14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.54905724 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.53360650 |
| 16 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.53042759 |
| 17 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.46272620 |
| 18 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.44119182 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.36447852 |
| 20 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.33232414 |
| 21 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.27453576 |
| 22 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.26390423 |
| 23 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.24672900 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.19594629 |
| 25 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.17114415 |
| 26 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.14601741 |
| 27 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.89331948 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.87720017 |
| 29 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.84437892 |
| 30 | * EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.79960031 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.79508533 |
| 32 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.78160306 |
| 33 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.72790276 |
| 34 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.63816488 |
| 35 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.61316841 |
| 36 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.56896006 |
| 37 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.49249860 |
| 38 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.44158102 |
| 39 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.40824798 |
| 40 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.40447486 |
| 41 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.38231813 |
| 42 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.37945598 |
| 43 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.37608543 |
| 44 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.37432451 |
| 45 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.37016246 |
| 46 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.33795201 |
| 47 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.33069563 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.32471092 |
| 49 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.30902520 |
| 50 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.30247443 |
| 51 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.29806843 |
| 52 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.29622001 |
| 53 | AR_25329375_ChIP-Seq_VCAP_Human | 1.23132490 |
| 54 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.20527844 |
| 55 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.19982160 |
| 56 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.19290042 |
| 57 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.19249158 |
| 58 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.18782855 |
| 59 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.17583798 |
| 60 | AR_19668381_ChIP-Seq_PC3_Human | 1.16678449 |
| 61 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15898046 |
| 62 | STAT3_23295773_ChIP-Seq_U87_Human | 1.15191797 |
| 63 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.14755880 |
| 64 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.14195871 |
| 65 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.12619694 |
| 66 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.12455654 |
| 67 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.12260020 |
| 68 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.10514834 |
| 69 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.10240904 |
| 70 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10071161 |
| 71 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.06748419 |
| 72 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.06059475 |
| 73 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.04438901 |
| 74 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.03744672 |
| 75 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.03361543 |
| 76 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.02869090 |
| 77 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.02859036 |
| 78 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.02373633 |
| 79 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.01903941 |
| 80 | TCF4_23295773_ChIP-Seq_U87_Human | 1.00623722 |
| 81 | KDM2B_26808549_Chip-Seq_K562_Human | 0.98423754 |
| 82 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.97260803 |
| 83 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.97083184 |
| 84 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.96265810 |
| 85 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.95510737 |
| 86 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.95492262 |
| 87 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.95048455 |
| 88 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.94783238 |
| 89 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.94646209 |
| 90 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.93643323 |
| 91 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.93611701 |
| 92 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.92015625 |
| 93 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.91439341 |
| 94 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.90963735 |
| 95 | VDR_22108803_ChIP-Seq_LS180_Human | 0.90233075 |
| 96 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.89993210 |
| 97 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.89147190 |
| 98 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.88415112 |
| 99 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.88406346 |
| 100 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.88009583 |
| 101 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.87967815 |
| 102 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.87761401 |
| 103 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.86862165 |
| 104 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.86651132 |
| 105 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86510531 |
| 106 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.86235998 |
| 107 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86183919 |
| 108 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.85701041 |
| 109 | JUN_21703547_ChIP-Seq_K562_Human | 0.85455530 |
| 110 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.84782800 |
| 111 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.84253949 |
| 112 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.84070761 |
| 113 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83245742 |
| 114 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.80208631 |
| 115 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.78944644 |
| 116 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.78730390 |
| 117 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.78689547 |
| 118 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.78261051 |
| 119 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.78001515 |
| 120 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.76662550 |
| 121 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.71990513 |
| 122 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.71990513 |
| 123 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.70959823 |
| 124 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.70774270 |
| 125 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.69572328 |
| 126 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.68899275 |
| 127 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.68811219 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.07471719 |
| 2 | MP0003880_abnormal_central_pattern | 4.96906096 |
| 3 | * MP0003635_abnormal_synaptic_transmissio | 4.05443247 |
| 4 | MP0004270_analgesia | 3.66380092 |
| 5 | MP0009745_abnormal_behavioral_response | 3.34736409 |
| 6 | MP0009046_muscle_twitch | 3.23895763 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.21408495 |
| 8 | MP0002064_seizures | 3.19782767 |
| 9 | MP0001968_abnormal_touch/_nociception | 3.14701124 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.76750143 |
| 11 | MP0002734_abnormal_mechanical_nocicepti | 2.75118611 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.74561245 |
| 13 | MP0002272_abnormal_nervous_system | 2.72108427 |
| 14 | MP0002736_abnormal_nociception_after | 2.50625476 |
| 15 | MP0001486_abnormal_startle_reflex | 2.50259322 |
| 16 | MP0002822_catalepsy | 2.48415816 |
| 17 | MP0002735_abnormal_chemical_nociception | 2.43800440 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.24974011 |
| 19 | MP0002733_abnormal_thermal_nociception | 2.18702083 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.16932267 |
| 21 | MP0006276_abnormal_autonomic_nervous | 2.15802082 |
| 22 | MP0001970_abnormal_pain_threshold | 2.10491147 |
| 23 | MP0002067_abnormal_sensory_capabilities | 2.06295586 |
| 24 | MP0008569_lethality_at_weaning | 1.91729247 |
| 25 | MP0002184_abnormal_innervation | 1.90626619 |
| 26 | MP0003329_amyloid_beta_deposits | 1.86756713 |
| 27 | MP0009780_abnormal_chondrocyte_physiolo | 1.85739255 |
| 28 | MP0002909_abnormal_adrenal_gland | 1.83567600 |
| 29 | MP0004858_abnormal_nervous_system | 1.76627551 |
| 30 | MP0001984_abnormal_olfaction | 1.76350275 |
| 31 | MP0004811_abnormal_neuron_physiology | 1.76054284 |
| 32 | * MP0002557_abnormal_social/conspecific_i | 1.68149601 |
| 33 | MP0000778_abnormal_nervous_system | 1.65659523 |
| 34 | MP0005646_abnormal_pituitary_gland | 1.64838132 |
| 35 | * MP0004924_abnormal_behavior | 1.64528809 |
| 36 | * MP0005386_behavior/neurological_phenoty | 1.64528809 |
| 37 | MP0000955_abnormal_spinal_cord | 1.59356455 |
| 38 | MP0001529_abnormal_vocalization | 1.57527418 |
| 39 | MP0003879_abnormal_hair_cell | 1.57176857 |
| 40 | MP0004142_abnormal_muscle_tone | 1.52748593 |
| 41 | MP0003122_maternal_imprinting | 1.49465784 |
| 42 | MP0003123_paternal_imprinting | 1.48658153 |
| 43 | MP0002882_abnormal_neuron_morphology | 1.46248704 |
| 44 | MP0002066_abnormal_motor_capabilities/c | 1.44028084 |
| 45 | MP0001905_abnormal_dopamine_level | 1.43514587 |
| 46 | MP0003787_abnormal_imprinting | 1.41496334 |
| 47 | MP0005645_abnormal_hypothalamus_physiol | 1.34926070 |
| 48 | MP0003633_abnormal_nervous_system | 1.30944256 |
| 49 | MP0004885_abnormal_endolymph | 1.29141667 |
| 50 | MP0000751_myopathy | 1.27263411 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.22408412 |
| 52 | MP0000013_abnormal_adipose_tissue | 1.15184557 |
| 53 | MP0002837_dystrophic_cardiac_calcinosis | 1.14576106 |
| 54 | MP0002229_neurodegeneration | 1.13358462 |
| 55 | * MP0001502_abnormal_circadian_rhythm | 1.13015010 |
| 56 | MP0010386_abnormal_urinary_bladder | 1.12165608 |
| 57 | MP0003631_nervous_system_phenotype | 1.10513043 |
| 58 | MP0004145_abnormal_muscle_electrophysio | 1.10006969 |
| 59 | MP0003121_genomic_imprinting | 1.08446713 |
| 60 | MP0002152_abnormal_brain_morphology | 1.04406905 |
| 61 | MP0008872_abnormal_physiological_respon | 1.02728459 |
| 62 | MP0008877_abnormal_DNA_methylation | 0.97890201 |
| 63 | MP0001188_hyperpigmentation | 0.96794945 |
| 64 | MP0002069_abnormal_eating/drinking_beha | 0.94272283 |
| 65 | MP0004742_abnormal_vestibular_system | 0.92333487 |
| 66 | MP0005535_abnormal_body_temperature | 0.89820919 |
| 67 | MP0004147_increased_porphyrin_level | 0.89143920 |
| 68 | MP0003634_abnormal_glial_cell | 0.89094217 |
| 69 | MP0004085_abnormal_heartbeat | 0.87053384 |
| 70 | MP0005499_abnormal_olfactory_system | 0.85862814 |
| 71 | MP0005394_taste/olfaction_phenotype | 0.85862814 |
| 72 | MP0008874_decreased_physiological_sensi | 0.85532821 |
| 73 | MP0002752_abnormal_somatic_nervous | 0.85020662 |
| 74 | MP0001963_abnormal_hearing_physiology | 0.83283102 |
| 75 | MP0004215_abnormal_myocardial_fiber | 0.82805144 |
| 76 | MP0001348_abnormal_lacrimal_gland | 0.82785493 |
| 77 | MP0002090_abnormal_vision | 0.82073088 |
| 78 | MP0002638_abnormal_pupillary_reflex | 0.81949355 |
| 79 | MP0000604_amyloidosis | 0.78647242 |
| 80 | MP0006072_abnormal_retinal_apoptosis | 0.76926122 |
| 81 | MP0000920_abnormal_myelination | 0.75962908 |
| 82 | MP0000631_abnormal_neuroendocrine_gland | 0.75296717 |
| 83 | MP0003632_abnormal_nervous_system | 0.74987540 |
| 84 | MP0003283_abnormal_digestive_organ | 0.74963827 |
| 85 | MP0008961_abnormal_basal_metabolism | 0.73064912 |
| 86 | MP0004233_abnormal_muscle_weight | 0.72356236 |
| 87 | MP0001177_atelectasis | 0.72169708 |
| 88 | MP0003137_abnormal_impulse_conducting | 0.70067416 |
| 89 | MP0004043_abnormal_pH_regulation | 0.68423567 |
| 90 | MP0001664_abnormal_digestion | 0.68206251 |
| 91 | MP0002876_abnormal_thyroid_physiology | 0.67860466 |
| 92 | MP0003690_abnormal_glial_cell | 0.66714390 |
| 93 | MP0003075_altered_response_to | 0.63232812 |
| 94 | MP0005167_abnormal_blood-brain_barrier | 0.63014176 |
| 95 | MP0001346_abnormal_lacrimal_gland | 0.62462109 |
| 96 | MP0001986_abnormal_taste_sensitivity | 0.61677178 |
| 97 | MP0004484_altered_response_of | 0.61662777 |
| 98 | MP0001485_abnormal_pinna_reflex | 0.61380057 |
| 99 | MP0003861_abnormal_nervous_system | 0.59384604 |
| 100 | MP0003183_abnormal_peptide_metabolism | 0.56301562 |
| 101 | MP0005623_abnormal_meninges_morphology | 0.56176566 |
| 102 | MP0010768_mortality/aging | 0.55844608 |
| 103 | MP0005253_abnormal_eye_physiology | 0.55700165 |
| 104 | MP0010770_preweaning_lethality | 0.55484023 |
| 105 | MP0002082_postnatal_lethality | 0.55484023 |
| 106 | MP0004130_abnormal_muscle_cell | 0.55255402 |
| 107 | MP0001299_abnormal_eye_distance/ | 0.55236125 |
| 108 | MP0000026_abnormal_inner_ear | 0.53266436 |
| 109 | * MP0001943_abnormal_respiration | 0.53003696 |
| 110 | MP0000747_muscle_weakness | 0.52949830 |
| 111 | MP0010769_abnormal_survival | 0.51831163 |
| 112 | MP0002653_abnormal_ependyma_morphology | 0.51680375 |
| 113 | MP0000569_abnormal_digit_pigmentation | 0.51416968 |
| 114 | * MP0003956_abnormal_body_size | 0.50734271 |
| 115 | MP0003938_abnormal_ear_development | 0.45141051 |
| 116 | * MP0002873_normal_phenotype | 0.42556285 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.36285718 |
| 2 | Myokymia (HP:0002411) | 7.05847984 |
| 3 | Focal seizures (HP:0007359) | 5.57791747 |
| 4 | Visual hallucinations (HP:0002367) | 5.51381943 |
| 5 | Atonic seizures (HP:0010819) | 5.02112020 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.95966067 |
| 7 | Febrile seizures (HP:0002373) | 4.65659870 |
| 8 | Progressive cerebellar ataxia (HP:0002073) | 4.42836726 |
| 9 | Absence seizures (HP:0002121) | 4.32553771 |
| 10 | Action tremor (HP:0002345) | 3.91452148 |
| 11 | Dialeptic seizures (HP:0011146) | 3.89550733 |
| 12 | Generalized tonic-clonic seizures (HP:0002069) | 3.86136208 |
| 13 | Supranuclear gaze palsy (HP:0000605) | 3.74311336 |
| 14 | Ankle clonus (HP:0011448) | 3.50901132 |
| 15 | Cerebral hypomyelination (HP:0006808) | 3.33844107 |
| 16 | Depression (HP:0000716) | 3.31612021 |
| 17 | Anxiety (HP:0000739) | 3.16307169 |
| 18 | Pheochromocytoma (HP:0002666) | 3.15796736 |
| 19 | Broad-based gait (HP:0002136) | 3.15426141 |
| 20 | Gaze-evoked nystagmus (HP:0000640) | 3.09276181 |
| 21 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.07750568 |
| 22 | Abnormal eating behavior (HP:0100738) | 3.06575494 |
| 23 | Dysdiadochokinesis (HP:0002075) | 3.06107343 |
| 24 | Poor eye contact (HP:0000817) | 3.05489060 |
| 25 | Truncal ataxia (HP:0002078) | 3.03768259 |
| 26 | Mutism (HP:0002300) | 2.99074201 |
| 27 | Dysmetria (HP:0001310) | 2.97813428 |
| 28 | Tetraplegia (HP:0002445) | 2.95429207 |
| 29 | Amblyopia (HP:0000646) | 2.91397503 |
| 30 | Hyperventilation (HP:0002883) | 2.89920399 |
| 31 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.88887340 |
| 32 | Obstructive sleep apnea (HP:0002870) | 2.85769150 |
| 33 | Limb dystonia (HP:0002451) | 2.85361965 |
| 34 | Sleep apnea (HP:0010535) | 2.81765768 |
| 35 | Impaired social interactions (HP:0000735) | 2.80840634 |
| 36 | Abnormal social behavior (HP:0012433) | 2.80840634 |
| 37 | Postural instability (HP:0002172) | 2.79859314 |
| 38 | Neuroendocrine neoplasm (HP:0100634) | 2.77832902 |
| 39 | Progressive inability to walk (HP:0002505) | 2.70384222 |
| 40 | Urinary urgency (HP:0000012) | 2.62011893 |
| 41 | Ventricular fibrillation (HP:0001663) | 2.61629915 |
| 42 | Abnormality of the lower motor neuron (HP:0002366) | 2.61091192 |
| 43 | Spastic gait (HP:0002064) | 2.59360336 |
| 44 | Scanning speech (HP:0002168) | 2.56491233 |
| 45 | Torticollis (HP:0000473) | 2.55480975 |
| 46 | Epileptiform EEG discharges (HP:0011182) | 2.54328109 |
| 47 | Peripheral hypomyelination (HP:0007182) | 2.52378292 |
| 48 | Genetic anticipation (HP:0003743) | 2.52268679 |
| 49 | Hemiparesis (HP:0001269) | 2.49055603 |
| 50 | Bradykinesia (HP:0002067) | 2.48497422 |
| 51 | Apathy (HP:0000741) | 2.48176893 |
| 52 | EEG with generalized epileptiform discharges (HP:0011198) | 2.46392484 |
| 53 | Focal dystonia (HP:0004373) | 2.44412825 |
| 54 | Papilledema (HP:0001085) | 2.43548245 |
| 55 | Polyphagia (HP:0002591) | 2.39626823 |
| 56 | Drooling (HP:0002307) | 2.37937307 |
| 57 | Excessive salivation (HP:0003781) | 2.37937307 |
| 58 | Impaired smooth pursuit (HP:0007772) | 2.36442626 |
| 59 | Failure to thrive in infancy (HP:0001531) | 2.36002200 |
| 60 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.35280676 |
| 61 | Insidious onset (HP:0003587) | 2.34671031 |
| 62 | Termporal pattern (HP:0011008) | 2.34671031 |
| 63 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.32712150 |
| 64 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.32712150 |
| 65 | Hypsarrhythmia (HP:0002521) | 2.31722510 |
| 66 | Neurofibrillary tangles (HP:0002185) | 2.30801204 |
| 67 | Cerebral inclusion bodies (HP:0100314) | 2.29748341 |
| 68 | Hemiplegia (HP:0002301) | 2.26185141 |
| 69 | Diminished motivation (HP:0000745) | 2.26012703 |
| 70 | Insomnia (HP:0100785) | 2.24660505 |
| 71 | CNS hypomyelination (HP:0003429) | 2.23242903 |
| 72 | Intention tremor (HP:0002080) | 2.23117289 |
| 73 | Abnormality of binocular vision (HP:0011514) | 2.23005963 |
| 74 | Diplopia (HP:0000651) | 2.23005963 |
| 75 | Agitation (HP:0000713) | 2.22913500 |
| 76 | Fetal akinesia sequence (HP:0001989) | 2.21340085 |
| 77 | Abnormality of the corticospinal tract (HP:0002492) | 2.21331456 |
| 78 | Craniofacial dystonia (HP:0012179) | 2.19239065 |
| 79 | Status epilepticus (HP:0002133) | 2.18651595 |
| 80 | Spastic tetraparesis (HP:0001285) | 2.15936803 |
| 81 | Inability to walk (HP:0002540) | 2.12760655 |
| 82 | Stereotypic behavior (HP:0000733) | 2.10403634 |
| 83 | Lower limb muscle weakness (HP:0007340) | 2.10329655 |
| 84 | Spastic tetraplegia (HP:0002510) | 2.08941479 |
| 85 | Delusions (HP:0000746) | 2.07695939 |
| 86 | Megalencephaly (HP:0001355) | 2.07575329 |
| 87 | Hypoventilation (HP:0002791) | 2.07186737 |
| 88 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.07111655 |
| 89 | Dysmetric saccades (HP:0000641) | 2.05661112 |
| 90 | Choreoathetosis (HP:0001266) | 2.04741085 |
| 91 | Generalized myoclonic seizures (HP:0002123) | 2.03818900 |
| 92 | Impaired vibratory sensation (HP:0002495) | 2.01027488 |
| 93 | Absent speech (HP:0001344) | 1.98491253 |
| 94 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.98253208 |
| 95 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.97497989 |
| 96 | Split foot (HP:0001839) | 1.97377724 |
| 97 | Gait imbalance (HP:0002141) | 1.95862099 |
| 98 | Incomplete penetrance (HP:0003829) | 1.95760666 |
| 99 | Psychosis (HP:0000709) | 1.95129829 |
| 100 | Hand muscle atrophy (HP:0009130) | 1.93401878 |
| 101 | Specific learning disability (HP:0001328) | 1.91563892 |
| 102 | Gait ataxia (HP:0002066) | 1.90603664 |
| 103 | Annular pancreas (HP:0001734) | 1.89211645 |
| 104 | Rigidity (HP:0002063) | 1.87818509 |
| 105 | Central scotoma (HP:0000603) | 1.87786235 |
| 106 | Clonus (HP:0002169) | 1.87398721 |
| 107 | Bundle branch block (HP:0011710) | 1.86526555 |
| 108 | Abnormal EKG (HP:0003115) | 1.84782658 |
| 109 | Unsteady gait (HP:0002317) | 1.83265779 |
| 110 | Rapidly progressive (HP:0003678) | 1.81675000 |
| 111 | Poor suck (HP:0002033) | 1.79631209 |
| 112 | Lower limb amyotrophy (HP:0007210) | 1.79495374 |
| 113 | Hypoplasia of the corpus callosum (HP:0002079) | 1.79266689 |
| 114 | Akinesia (HP:0002304) | 1.78663116 |
| 115 | Hypercortisolism (HP:0001578) | 1.78125613 |
| 116 | Resting tremor (HP:0002322) | 1.78002010 |
| 117 | Retinal dysplasia (HP:0007973) | 1.77937936 |
| 118 | Neuronal loss in central nervous system (HP:0002529) | 1.77330023 |
| 119 | Abnormal hair whorl (HP:0010721) | 1.74620409 |
| 120 | Amyotrophic lateral sclerosis (HP:0007354) | 1.73646097 |
| 121 | Paraplegia (HP:0010550) | 1.73421667 |
| 122 | Spinal canal stenosis (HP:0003416) | 1.71594920 |
| 123 | Distal upper limb amyotrophy (HP:0007149) | 1.67205422 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.24762758 |
| 2 | MAP3K9 | 3.91528177 |
| 3 | EPHA4 | 3.65881759 |
| 4 | MAP3K4 | 3.05304654 |
| 5 | MINK1 | 2.93129662 |
| 6 | MARK1 | 2.91118977 |
| 7 | MAP3K12 | 2.65763317 |
| 8 | MAP2K7 | 2.57575523 |
| 9 | DAPK2 | 2.40496765 |
| 10 | PAK6 | 2.32987270 |
| 11 | CASK | 2.18863000 |
| 12 | KSR2 | 2.18259003 |
| 13 | MAP2K4 | 1.97574087 |
| 14 | ARAF | 1.89148750 |
| 15 | NTRK2 | 1.88914961 |
| 16 | NTRK1 | 1.85745997 |
| 17 | PRKD3 | 1.74267143 |
| 18 | GRK5 | 1.72377304 |
| 19 | CDK19 | 1.69633587 |
| 20 | CAMKK1 | 1.67955639 |
| 21 | KSR1 | 1.56146313 |
| 22 | PLK2 | 1.55961242 |
| 23 | RIPK4 | 1.54394710 |
| 24 | CDK5 | 1.53115336 |
| 25 | DAPK1 | 1.52041320 |
| 26 | MAPK13 | 1.34792639 |
| 27 | PRPF4B | 1.31807312 |
| 28 | PNCK | 1.30969037 |
| 29 | PRKCG | 1.27501417 |
| 30 | CAMKK2 | 1.25705891 |
| 31 | UHMK1 | 1.24914844 |
| 32 | STK38 | 1.24595275 |
| 33 | PHKG2 | 1.24482110 |
| 34 | PHKG1 | 1.24482110 |
| 35 | TNIK | 1.19343079 |
| 36 | MAP3K13 | 1.16488029 |
| 37 | MAP3K2 | 1.12222757 |
| 38 | FES | 1.10717790 |
| 39 | SIK2 | 1.00992265 |
| 40 | CDK18 | 1.00712104 |
| 41 | CAMK2A | 1.00457680 |
| 42 | CDK14 | 0.99014814 |
| 43 | LATS2 | 0.97812110 |
| 44 | SGK223 | 0.97742116 |
| 45 | SGK494 | 0.97742116 |
| 46 | CDK15 | 0.96782504 |
| 47 | LMTK2 | 0.96012550 |
| 48 | OXSR1 | 0.95070355 |
| 49 | RIPK1 | 0.92607051 |
| 50 | PINK1 | 0.92453058 |
| 51 | TYRO3 | 0.86358433 |
| 52 | CDK11A | 0.84710383 |
| 53 | CAMK1 | 0.84343617 |
| 54 | PAK3 | 0.83376537 |
| 55 | PRKCH | 0.81765122 |
| 56 | NEK6 | 0.81665673 |
| 57 | CAMK2B | 0.81354206 |
| 58 | RET | 0.80867534 |
| 59 | TAOK1 | 0.79243102 |
| 60 | MAPK12 | 0.78905865 |
| 61 | NEK1 | 0.76873268 |
| 62 | PKN1 | 0.76186360 |
| 63 | RAF1 | 0.75367790 |
| 64 | BRSK1 | 0.74876398 |
| 65 | STK11 | 0.74852000 |
| 66 | NME1 | 0.73880970 |
| 67 | PTK2B | 0.73272523 |
| 68 | MAP3K11 | 0.71581823 |
| 69 | TESK1 | 0.71400462 |
| 70 | TNK2 | 0.70356496 |
| 71 | DYRK1A | 0.69891738 |
| 72 | CSNK1G2 | 0.69401263 |
| 73 | MAP3K1 | 0.69084971 |
| 74 | SGK2 | 0.69012374 |
| 75 | DYRK2 | 0.68072745 |
| 76 | SIK3 | 0.65026840 |
| 77 | WNK1 | 0.61694188 |
| 78 | CAMK2D | 0.59604549 |
| 79 | BMPR2 | 0.59366172 |
| 80 | PDK1 | 0.58337105 |
| 81 | PDPK1 | 0.58315662 |
| 82 | BRAF | 0.57621250 |
| 83 | CAMK2G | 0.57383674 |
| 84 | MARK2 | 0.56444205 |
| 85 | PRKCE | 0.56410499 |
| 86 | SGK1 | 0.56128482 |
| 87 | SGK3 | 0.54552740 |
| 88 | CCNB1 | 0.54184746 |
| 89 | FER | 0.53009641 |
| 90 | ALK | 0.51229049 |
| 91 | LIMK1 | 0.51184698 |
| 92 | PRKCZ | 0.48462764 |
| 93 | CSNK1G3 | 0.47814098 |
| 94 | MAP2K1 | 0.47731744 |
| 95 | DAPK3 | 0.47681034 |
| 96 | CDC42BPA | 0.46173132 |
| 97 | CSNK1A1L | 0.46084160 |
| 98 | BCR | 0.45518781 |
| 99 | RPS6KA3 | 0.43563315 |
| 100 | ROCK2 | 0.39406957 |
| 101 | WNK3 | 0.39295188 |
| 102 | SCYL2 | 0.38967410 |
| 103 | WNK4 | 0.38780405 |
| 104 | MAPK10 | 0.38443662 |
| 105 | RPS6KA2 | 0.37589144 |
| 106 | STK39 | 0.37500752 |
| 107 | FYN | 0.36822158 |
| 108 | CAMK4 | 0.36214720 |
| 109 | MAPKAPK5 | 0.36172566 |
| 110 | PRKCA | 0.35245345 |
| 111 | CAMK1G | 0.35052738 |
| 112 | PRKACA | 0.30370523 |
| 113 | MAPK8 | 0.28869203 |
| 114 | CSNK1D | 0.28706318 |
| 115 | CSNK1E | 0.28536836 |
| 116 | PRKG1 | 0.26511692 |
| 117 | CSNK1A1 | 0.26444480 |
| 118 | PRKCB | 0.25650900 |
| 119 | FGFR2 | 0.23126425 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.77827796 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.69144031 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.77228862 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.74665414 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.65222398 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.62296082 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.51020035 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.45431696 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.43244424 |
| 10 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.39294732 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.37752703 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.17854189 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.06659199 |
| 14 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.02897514 |
| 15 | * Insulin secretion_Homo sapiens_hsa04911 | 2.00445681 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.91494549 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 1.84588808 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.79646460 |
| 19 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.77931772 |
| 20 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.72732187 |
| 21 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.69843668 |
| 22 | Cocaine addiction_Homo sapiens_hsa05030 | 1.65654034 |
| 23 | Long-term depression_Homo sapiens_hsa04730 | 1.64920456 |
| 24 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.64784414 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.62894955 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.57610220 |
| 27 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.48273014 |
| 28 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.36751505 |
| 29 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.35894607 |
| 30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.34868136 |
| 31 | Gap junction_Homo sapiens_hsa04540 | 1.31992074 |
| 32 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.27998677 |
| 33 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.27732857 |
| 34 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.21845852 |
| 35 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.21045411 |
| 36 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.16317291 |
| 37 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.11645142 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.09106988 |
| 39 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.07418536 |
| 40 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.06369644 |
| 41 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.04598499 |
| 42 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.02690291 |
| 43 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.99961009 |
| 44 | Glioma_Homo sapiens_hsa05214 | 0.97285903 |
| 45 | Axon guidance_Homo sapiens_hsa04360 | 0.96262700 |
| 46 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.95392705 |
| 47 | Melanogenesis_Homo sapiens_hsa04916 | 0.91779258 |
| 48 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.91399776 |
| 49 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.90461995 |
| 50 | Alzheimers disease_Homo sapiens_hsa05010 | 0.87734231 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.87689770 |
| 52 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.82623987 |
| 53 | Parkinsons disease_Homo sapiens_hsa05012 | 0.82035408 |
| 54 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.80316508 |
| 55 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.79706647 |
| 56 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.72872440 |
| 57 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.72618885 |
| 58 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.72245687 |
| 59 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.71225074 |
| 60 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.69995258 |
| 61 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.69826835 |
| 62 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.61984951 |
| 63 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.61047598 |
| 64 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.59835714 |
| 65 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.59834117 |
| 66 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.57975323 |
| 67 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.57079285 |
| 68 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.56755077 |
| 69 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.53745709 |
| 70 | Alcoholism_Homo sapiens_hsa05034 | 0.53460094 |
| 71 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.52903184 |
| 72 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.51721343 |
| 73 | Circadian rhythm_Homo sapiens_hsa04710 | 0.51256839 |
| 74 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.50993075 |
| 75 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.50074780 |
| 76 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.48609377 |
| 77 | Endocytosis_Homo sapiens_hsa04144 | 0.48253962 |
| 78 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.48020758 |
| 79 | Huntingtons disease_Homo sapiens_hsa05016 | 0.47943526 |
| 80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.44603041 |
| 81 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.44518763 |
| 82 | Prion diseases_Homo sapiens_hsa05020 | 0.43919864 |
| 83 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.42717496 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.41882053 |
| 85 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.41805856 |
| 86 | Bile secretion_Homo sapiens_hsa04976 | 0.41759233 |
| 87 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.40243954 |
| 88 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.38868576 |
| 89 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.37239959 |
| 90 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.36839040 |
| 91 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.36675948 |
| 92 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.36086617 |
| 93 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.35940982 |
| 94 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.34118251 |
| 95 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.33667495 |
| 96 | Endometrial cancer_Homo sapiens_hsa05213 | 0.33160004 |
| 97 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.32505392 |
| 98 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.30634308 |
| 99 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.30183627 |
| 100 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.29993372 |
| 101 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.29849247 |
| 102 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.28395490 |
| 103 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.28295438 |
| 104 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.28102620 |
| 105 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.27305692 |
| 106 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.25487366 |
| 107 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.24181454 |
| 108 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.23972100 |
| 109 | Mineral absorption_Homo sapiens_hsa04978 | 0.21988392 |
| 110 | Tight junction_Homo sapiens_hsa04530 | 0.20689593 |
| 111 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.19883810 |
| 112 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.18514398 |
| 113 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.18425347 |

