RAB3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20539694
2vocalization behavior (GO:0071625)6.08382298
3synaptic vesicle exocytosis (GO:0016079)5.91055646
4neuron cell-cell adhesion (GO:0007158)5.55307900
5glutamate secretion (GO:0014047)5.41742742
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39317746
7synaptic vesicle maturation (GO:0016188)5.33349397
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26634997
9locomotory exploration behavior (GO:0035641)5.13555665
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.13156573
11regulation of synaptic vesicle exocytosis (GO:2000300)4.85330798
12neurotransmitter secretion (GO:0007269)4.82857825
13regulation of glutamate receptor signaling pathway (GO:1900449)4.82809450
14protein localization to synapse (GO:0035418)4.76451301
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.62277017
16pyrimidine nucleobase catabolic process (GO:0006208)4.51975441
17exploration behavior (GO:0035640)4.46532075
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.37283672
19gamma-aminobutyric acid transport (GO:0015812)4.34225703
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34058511
21regulation of synaptic vesicle transport (GO:1902803)4.33585141
22neuronal action potential propagation (GO:0019227)4.24826889
23regulation of synapse structural plasticity (GO:0051823)4.20805512
24layer formation in cerebral cortex (GO:0021819)4.18120213
25regulation of neuronal synaptic plasticity (GO:0048168)4.16642953
26glutamate receptor signaling pathway (GO:0007215)4.13441612
27neurotransmitter transport (GO:0006836)4.06229724
28neuron-neuron synaptic transmission (GO:0007270)4.04349827
29nucleobase catabolic process (GO:0046113)4.03086693
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.02631521
31proline transport (GO:0015824)4.02044317
32synaptic transmission, glutamatergic (GO:0035249)4.00209080
33neuron recognition (GO:0008038)3.93284904
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.91250660
35dendritic spine morphogenesis (GO:0060997)3.86179504
36regulation of neurotransmitter levels (GO:0001505)3.80801967
37neurotransmitter-gated ion channel clustering (GO:0072578)3.78323542
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74563986
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.74502077
40long-term memory (GO:0007616)3.73508381
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69208180
42transmission of nerve impulse (GO:0019226)3.65517800
43prepulse inhibition (GO:0060134)3.64411995
44positive regulation of synapse maturation (GO:0090129)3.64277278
45positive regulation of membrane potential (GO:0045838)3.58712281
46mating behavior (GO:0007617)3.58705303
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57434359
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57107922
49regulation of postsynaptic membrane potential (GO:0060078)3.56822980
50cerebellar granule cell differentiation (GO:0021707)3.54117056
51response to histamine (GO:0034776)3.53132451
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43492051
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.42956537
54postsynaptic membrane organization (GO:0001941)3.42506979
55regulation of vesicle fusion (GO:0031338)3.41490894
56axonal fasciculation (GO:0007413)3.41148783
57auditory behavior (GO:0031223)3.40267207
58establishment of mitochondrion localization (GO:0051654)3.40192877
59cerebellar Purkinje cell differentiation (GO:0021702)3.39819258
60synapse assembly (GO:0007416)3.39690148
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38779501
62synaptic vesicle endocytosis (GO:0048488)3.37862819
63cellular potassium ion homeostasis (GO:0030007)3.34360326
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34169798
65activation of protein kinase A activity (GO:0034199)3.32572745
66presynaptic membrane assembly (GO:0097105)3.29705375
67regulation of synaptic plasticity (GO:0048167)3.29571493
68regulation of neurotransmitter secretion (GO:0046928)3.28585950
69response to auditory stimulus (GO:0010996)3.28502750
70intraspecies interaction between organisms (GO:0051703)3.26117127
71social behavior (GO:0035176)3.26117127
72long-term synaptic potentiation (GO:0060291)3.23482142
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23289478
74detection of calcium ion (GO:0005513)3.23155842
75membrane hyperpolarization (GO:0060081)3.22809640
76striatum development (GO:0021756)3.18064988
77central nervous system projection neuron axonogenesis (GO:0021952)3.18030324
78membrane depolarization (GO:0051899)3.16798879
79behavioral response to cocaine (GO:0048148)3.15327426
80regulation of neurotransmitter transport (GO:0051588)3.14189186
81startle response (GO:0001964)3.12156958
82neuromuscular process controlling posture (GO:0050884)3.12068338
83neuromuscular synaptic transmission (GO:0007274)3.10858364
84serotonin metabolic process (GO:0042428)3.10836274
85regulation of dendritic spine morphogenesis (GO:0061001)3.10357265
86learning (GO:0007612)3.09894497
87regulation of synaptic transmission, GABAergic (GO:0032228)3.08600282
88adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06391363
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05891559
90synaptic vesicle transport (GO:0048489)3.05862888
91establishment of synaptic vesicle localization (GO:0097480)3.05862888
92synaptic transmission (GO:0007268)3.05853519
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04561416
94positive regulation of neurotransmitter transport (GO:0051590)3.04339439
95positive regulation of synapse assembly (GO:0051965)3.04308739
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04272019
97dopamine biosynthetic process (GO:0042416)3.04181649
98presynaptic membrane organization (GO:0097090)3.04013572
99mechanosensory behavior (GO:0007638)3.03020565
100membrane depolarization during action potential (GO:0086010)3.02937218
101negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02892026
102innervation (GO:0060384)3.02236718
103dendrite morphogenesis (GO:0048813)3.01438057
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01191265
105positive regulation of dendritic spine development (GO:0060999)3.01026405
106response to amphetamine (GO:0001975)3.00353299
107catecholamine transport (GO:0051937)2.99133187
108cell migration in hindbrain (GO:0021535)2.98474959
109positive regulation of dendritic spine morphogenesis (GO:0061003)2.98342664
110potassium ion homeostasis (GO:0055075)2.98039709
111vesicle transport along microtubule (GO:0047496)2.97460730
112regulation of synapse maturation (GO:0090128)2.97051977
113synapse organization (GO:0050808)2.96623008
114neuronal action potential (GO:0019228)2.95753240
115sodium ion export (GO:0071436)2.92747921
116neuromuscular process controlling balance (GO:0050885)2.92411611
117neuronal ion channel clustering (GO:0045161)2.92152945
118positive regulation of synaptic transmission (GO:0050806)2.91374548
119dendritic spine organization (GO:0097061)2.91162607
120establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.90749383
121mitochondrion transport along microtubule (GO:0047497)2.90749383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41276894
2GBX2_23144817_ChIP-Seq_PC3_Human3.80073073
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19750171
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08929437
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07055564
6REST_21632747_ChIP-Seq_MESCs_Mouse2.74330640
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65071232
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65071232
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63686761
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58236204
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52193173
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50204553
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.49608572
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46251708
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45555844
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30675496
17DROSHA_22980978_ChIP-Seq_HELA_Human2.29891799
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.27271443
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25711111
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.24417175
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22707340
22* TAF15_26573619_Chip-Seq_HEK293_Human2.21942491
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.20357410
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.17191494
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11143390
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.10656264
27* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09451370
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07686692
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91487025
30AR_21572438_ChIP-Seq_LNCaP_Human1.89266085
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88279381
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78071927
33SMAD4_21799915_ChIP-Seq_A2780_Human1.77733038
34IGF1R_20145208_ChIP-Seq_DFB_Human1.71038662
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62670946
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60753469
37P300_19829295_ChIP-Seq_ESCs_Human1.59191117
38ZNF274_21170338_ChIP-Seq_K562_Hela1.57408184
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57278594
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54960461
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51015890
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.45260692
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.45090556
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41423348
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41048808
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.40172323
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39727478
48* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37329459
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37150669
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37047008
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36708562
52* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36421101
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35288347
54* AR_25329375_ChIP-Seq_VCAP_Human1.34717608
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33471059
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31351826
57* PIAS1_25552417_ChIP-Seq_VCAP_Human1.29802279
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29593093
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28600916
60* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28015773
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.26904959
62RNF2_27304074_Chip-Seq_NSC_Mouse1.26707792
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26262153
64* STAT3_23295773_ChIP-Seq_U87_Human1.24355800
65FUS_26573619_Chip-Seq_HEK293_Human1.19849489
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17406720
67* AR_19668381_ChIP-Seq_PC3_Human1.16657706
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14889711
69* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14302074
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13589358
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11757890
72* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10402653
73* TCF4_23295773_ChIP-Seq_U87_Human1.10291007
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08519669
75RUNX2_22187159_ChIP-Seq_PCA_Human1.08028463
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07867174
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06848175
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05195108
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03826150
80* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03615469
81ER_23166858_ChIP-Seq_MCF-7_Human1.03309282
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.03185738
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.02887196
84BCAT_22108803_ChIP-Seq_LS180_Human1.01653960
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01607444
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01548302
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01498138
88AHR_22903824_ChIP-Seq_MCF-7_Human1.00910737
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.00595658
90* JUN_21703547_ChIP-Seq_K562_Human1.00499035
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98434526
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97481063
93TP53_18474530_ChIP-ChIP_U2OS_Human0.97210484
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96918099
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96286400
96VDR_22108803_ChIP-Seq_LS180_Human0.96070673
97SOX9_26525672_Chip-Seq_HEART_Mouse0.96032353
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94961620
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94046852
100* KDM2B_26808549_Chip-Seq_REH_Human0.92390638
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.92235922
102* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92125955
103P53_22387025_ChIP-Seq_ESCs_Mouse0.92088876
104FLI1_27457419_Chip-Seq_LIVER_Mouse0.91681368
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91585258
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91585258
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91021023
108* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89487531
109TP53_16413492_ChIP-PET_HCT116_Human0.89237193
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.86610458
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83947854
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82941603
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82039332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.76630476
2MP0003880_abnormal_central_pattern5.44863076
3MP0003635_abnormal_synaptic_transmissio4.07017315
4MP0009745_abnormal_behavioral_response3.43825347
5MP0009046_muscle_twitch3.35652274
6MP0004270_analgesia3.26522640
7MP0002822_catalepsy3.22494118
8MP0002064_seizures3.22364642
9MP0002063_abnormal_learning/memory/cond3.19943069
10MP0001968_abnormal_touch/_nociception3.00118045
11MP0005423_abnormal_somatic_nervous2.91939686
12MP0002572_abnormal_emotion/affect_behav2.82621697
13MP0006276_abnormal_autonomic_nervous2.66669611
14MP0002734_abnormal_mechanical_nocicepti2.62332935
15MP0002272_abnormal_nervous_system2.57851998
16MP0001486_abnormal_startle_reflex2.51116144
17MP0001501_abnormal_sleep_pattern2.45382544
18MP0002735_abnormal_chemical_nociception2.34235477
19MP0002736_abnormal_nociception_after2.31947528
20MP0002733_abnormal_thermal_nociception2.20764144
21MP0001440_abnormal_grooming_behavior2.19641782
22MP0001529_abnormal_vocalization2.13971871
23MP0001970_abnormal_pain_threshold2.04643646
24MP0002067_abnormal_sensory_capabilities2.04558943
25MP0005386_behavior/neurological_phenoty1.97083210
26MP0004924_abnormal_behavior1.97083210
27MP0001905_abnormal_dopamine_level1.93583749
28MP0002184_abnormal_innervation1.90994489
29MP0002557_abnormal_social/conspecific_i1.85908767
30MP0002909_abnormal_adrenal_gland1.81456049
31MP0003122_maternal_imprinting1.79135049
32MP0000778_abnormal_nervous_system1.78456515
33MP0005646_abnormal_pituitary_gland1.76749091
34MP0003329_amyloid_beta_deposits1.69354904
35MP0008569_lethality_at_weaning1.69077456
36MP0001984_abnormal_olfaction1.68396385
37MP0004811_abnormal_neuron_physiology1.66719249
38MP0009780_abnormal_chondrocyte_physiolo1.61493226
39MP0004858_abnormal_nervous_system1.55302240
40MP0005645_abnormal_hypothalamus_physiol1.54880516
41MP0001188_hyperpigmentation1.54352303
42MP0000955_abnormal_spinal_cord1.45209351
43MP0002066_abnormal_motor_capabilities/c1.41830624
44MP0003787_abnormal_imprinting1.41122302
45MP0004142_abnormal_muscle_tone1.39136423
46MP0002882_abnormal_neuron_morphology1.36611403
47MP0003879_abnormal_hair_cell1.34301854
48MP0008877_abnormal_DNA_methylation1.33604858
49MP0001502_abnormal_circadian_rhythm1.23242104
50MP0000569_abnormal_digit_pigmentation1.22937599
51MP0008872_abnormal_physiological_respon1.19250781
52MP0003633_abnormal_nervous_system1.15437700
53MP0004885_abnormal_endolymph1.12192480
54MP0010386_abnormal_urinary_bladder1.09865456
55MP0002152_abnormal_brain_morphology1.06893388
56MP0002837_dystrophic_cardiac_calcinosis1.05348638
57MP0003631_nervous_system_phenotype1.04191670
58MP0000751_myopathy1.02820357
59MP0004742_abnormal_vestibular_system0.95189729
60MP0005535_abnormal_body_temperature0.95075679
61MP0002069_abnormal_eating/drinking_beha0.92896657
62MP0002229_neurodegeneration0.92749303
63MP0005187_abnormal_penis_morphology0.92349649
64MP0002638_abnormal_pupillary_reflex0.91055868
65MP0005551_abnormal_eye_electrophysiolog0.90292062
66MP0008874_decreased_physiological_sensi0.87229819
67MP0000631_abnormal_neuroendocrine_gland0.86743915
68MP0005409_darkened_coat_color0.86533543
69MP0000013_abnormal_adipose_tissue0.82664933
70MP0005499_abnormal_olfactory_system0.82502605
71MP0005394_taste/olfaction_phenotype0.82502605
72MP0001177_atelectasis0.82139548
73MP0004085_abnormal_heartbeat0.82005606
74MP0006072_abnormal_retinal_apoptosis0.80501122
75MP0001963_abnormal_hearing_physiology0.80298905
76MP0004145_abnormal_muscle_electrophysio0.79793105
77MP0003632_abnormal_nervous_system0.79549827
78MP0004133_heterotaxia0.79201096
79MP0001485_abnormal_pinna_reflex0.76906976
80MP0005253_abnormal_eye_physiology0.75890787
81MP0002752_abnormal_somatic_nervous0.75643185
82MP0001664_abnormal_digestion0.75361888
83MP0003634_abnormal_glial_cell0.74911869
84MP0002090_abnormal_vision0.71965985
85MP0004147_increased_porphyrin_level0.71617766
86MP0000604_amyloidosis0.70326478
87MP0002876_abnormal_thyroid_physiology0.68703902
88MP0002102_abnormal_ear_morphology0.67953580
89MP0004215_abnormal_myocardial_fiber0.67608488
90MP0001986_abnormal_taste_sensitivity0.67032540
91MP0000566_synostosis0.66366332
92MP0003690_abnormal_glial_cell0.65156742
93MP0001944_abnormal_pancreas_morphology0.62949878
94MP0000026_abnormal_inner_ear0.61213789
95MP0004484_altered_response_of0.61166335
96MP0003283_abnormal_digestive_organ0.60542168
97MP0003137_abnormal_impulse_conducting0.60540892
98MP0001943_abnormal_respiration0.60486729
99MP0003121_genomic_imprinting0.58643332
100MP0003890_abnormal_embryonic-extraembry0.58285042
101MP0004043_abnormal_pH_regulation0.57997250
102MP0003119_abnormal_digestive_system0.55566855
103MP0000920_abnormal_myelination0.55182817
104MP0001299_abnormal_eye_distance/0.54028147
105MP0010770_preweaning_lethality0.53685299
106MP0002082_postnatal_lethality0.53685299
107MP0010769_abnormal_survival0.52686407
108MP0008961_abnormal_basal_metabolism0.52489270
109MP0005623_abnormal_meninges_morphology0.52222936
110MP0003861_abnormal_nervous_system0.52120920
111MP0003123_paternal_imprinting0.50922882
112MP0003956_abnormal_body_size0.50224824
113MP0010768_mortality/aging0.49428998
114MP0004233_abnormal_muscle_weight0.48587308
115MP0002751_abnormal_autonomic_nervous0.48536488

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.73152351
2Myokymia (HP:0002411)6.03825932
3Focal seizures (HP:0007359)5.84696489
4Visual hallucinations (HP:0002367)5.26062858
5Atonic seizures (HP:0010819)4.84951482
6Epileptic encephalopathy (HP:0200134)4.73141746
7Febrile seizures (HP:0002373)4.58641723
8Progressive cerebellar ataxia (HP:0002073)4.57089525
9Limb dystonia (HP:0002451)4.56029147
10Absence seizures (HP:0002121)4.25540557
11Generalized tonic-clonic seizures (HP:0002069)3.98239658
12Dialeptic seizures (HP:0011146)3.87467089
13Hyperventilation (HP:0002883)3.64730940
14Broad-based gait (HP:0002136)3.62159948
15Progressive inability to walk (HP:0002505)3.59897835
16Supranuclear gaze palsy (HP:0000605)3.56512043
17Action tremor (HP:0002345)3.28428649
18Pheochromocytoma (HP:0002666)3.26415764
19Ankle clonus (HP:0011448)3.16932442
20Mutism (HP:0002300)3.16434578
21Papilledema (HP:0001085)3.13283770
22Poor eye contact (HP:0000817)3.11852837
23Depression (HP:0000716)3.10689342
24Truncal ataxia (HP:0002078)3.09465093
25Anxiety (HP:0000739)3.05781219
26Abnormal eating behavior (HP:0100738)3.05468380
27Gaze-evoked nystagmus (HP:0000640)3.05017547
28Impaired vibration sensation in the lower limbs (HP:0002166)2.99537669
29Abnormal social behavior (HP:0012433)2.96833079
30Impaired social interactions (HP:0000735)2.96833079
31Dysdiadochokinesis (HP:0002075)2.94173591
32Neuroendocrine neoplasm (HP:0100634)2.87385852
33Amblyopia (HP:0000646)2.85374296
34Drooling (HP:0002307)2.83125681
35Excessive salivation (HP:0003781)2.83125681
36Urinary bladder sphincter dysfunction (HP:0002839)2.83029851
37Polyphagia (HP:0002591)2.80570939
38Dysmetria (HP:0001310)2.76870290
39Cerebral inclusion bodies (HP:0100314)2.73368793
40Postural instability (HP:0002172)2.71821242
41Neurofibrillary tangles (HP:0002185)2.65982598
42Failure to thrive in infancy (HP:0001531)2.59797529
43Bradykinesia (HP:0002067)2.58923106
44Inability to walk (HP:0002540)2.57400005
45Epileptiform EEG discharges (HP:0011182)2.57148011
46Diplopia (HP:0000651)2.55526248
47Abnormality of binocular vision (HP:0011514)2.55526248
48Genetic anticipation (HP:0003743)2.53665986
49Fetal akinesia sequence (HP:0001989)2.53167388
50EEG with generalized epileptiform discharges (HP:0011198)2.49092424
51Hemiparesis (HP:0001269)2.47021639
52Urinary urgency (HP:0000012)2.46797297
53Insidious onset (HP:0003587)2.42673334
54Termporal pattern (HP:0011008)2.42673334
55Spastic gait (HP:0002064)2.42350903
56Agitation (HP:0000713)2.42126238
57Sleep apnea (HP:0010535)2.40131307
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39663937
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.39663937
60Torticollis (HP:0000473)2.38324834
61Absent speech (HP:0001344)2.37263043
62Hypsarrhythmia (HP:0002521)2.36740087
63Abnormality of the corticospinal tract (HP:0002492)2.33485498
64Impaired smooth pursuit (HP:0007772)2.32481328
65Focal dystonia (HP:0004373)2.30554591
66Muscular hypotonia of the trunk (HP:0008936)2.28424168
67Hypoventilation (HP:0002791)2.27301524
68Scanning speech (HP:0002168)2.25856928
69Spastic tetraplegia (HP:0002510)2.20907724
70Generalized myoclonic seizures (HP:0002123)2.19988446
71Status epilepticus (HP:0002133)2.18496590
72Abnormality of ocular smooth pursuit (HP:0000617)2.13782091
73Stereotypic behavior (HP:0000733)2.12959022
74Gait imbalance (HP:0002141)2.12513778
75Amyotrophic lateral sclerosis (HP:0007354)2.11454720
76Blue irides (HP:0000635)2.08336611
77Craniofacial dystonia (HP:0012179)2.06558584
78Diminished movement (HP:0002374)2.06451694
79Lissencephaly (HP:0001339)2.04841011
80Intention tremor (HP:0002080)2.03960889
81Akinesia (HP:0002304)2.03704353
82Lower limb muscle weakness (HP:0007340)2.03347785
83Hemiplegia (HP:0002301)2.02908723
84Psychosis (HP:0000709)2.00742175
85Protruding tongue (HP:0010808)2.00734738
86Abnormality of the lower motor neuron (HP:0002366)1.99476967
87Neoplasm of the peripheral nervous system (HP:0100007)1.98538026
88Abnormality of the labia minora (HP:0012880)1.98121291
89Rigidity (HP:0002063)1.96210870
90Gait ataxia (HP:0002066)1.94459696
91Specific learning disability (HP:0001328)1.94046349
92Abnormality of salivation (HP:0100755)1.91532621
93Hyperthyroidism (HP:0000836)1.90875803
94Neuronal loss in central nervous system (HP:0002529)1.90549771
95Abnormal hair whorl (HP:0010721)1.89849200
96Impaired vibratory sensation (HP:0002495)1.89740138
97Morphological abnormality of the pyramidal tract (HP:0002062)1.89327866
98Ventricular fibrillation (HP:0001663)1.87502994
99Incomplete penetrance (HP:0003829)1.86835763
100Inappropriate behavior (HP:0000719)1.86401681
101Esotropia (HP:0000565)1.85997040
102Dysmetric saccades (HP:0000641)1.81794497
103Delusions (HP:0000746)1.81285383
104Megalencephaly (HP:0001355)1.80409502
105Exotropia (HP:0000577)1.79065091
106Pachygyria (HP:0001302)1.77436153
107Restlessness (HP:0000711)1.76578004
108Hypothermia (HP:0002045)1.76154558
109Poor suck (HP:0002033)1.74557205
110Medial flaring of the eyebrow (HP:0010747)1.74207872
111Prolonged QT interval (HP:0001657)1.74112138
112Postural tremor (HP:0002174)1.72722635
113Cerebral hypomyelination (HP:0006808)1.70863765
114Spastic tetraparesis (HP:0001285)1.69958244
115Dyskinesia (HP:0100660)1.68996115
116Congenital primary aphakia (HP:0007707)1.66262838
117Aqueductal stenosis (HP:0002410)1.65179901
118Clonus (HP:0002169)1.63140465
119Paraplegia (HP:0010550)1.63017600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.32974046
2MAP3K93.89663931
3MARK13.59254538
4MAP3K43.46778448
5EPHA43.32137993
6MAP3K123.08942239
7MAP2K73.07666302
8MINK12.74450788
9PNCK2.39987919
10CASK2.33534472
11NTRK22.32760093
12MAP2K42.27812235
13NTRK12.05426104
14PAK61.84168182
15DAPK21.80539366
16KSR21.69127664
17GRK51.67560194
18TNIK1.62678738
19FRK1.61516621
20DYRK21.60699140
21RIPK41.59016009
22MAPK131.56217936
23CDK51.51526064
24KSR11.50891482
25PLK21.49243932
26SIK21.47703143
27ARAF1.39716107
28DAPK11.34374196
29CAMKK11.31876540
30FES1.24368946
31PRKCG1.20844273
32CDK191.19500119
33CSNK1G21.19160362
34LATS21.17603005
35PRKD31.17550085
36UHMK11.16675467
37CAMK2A1.10727124
38PHKG21.09299342
39PHKG11.09299342
40FGFR21.07670867
41STK380.99578743
42CDK180.93451287
43MAP3K130.92588639
44CDK140.91322831
45CAMKK20.90879853
46CDK150.89952119
47CAMK2B0.87726073
48RET0.87415504
49PRPF4B0.86891300
50TRIM280.86326386
51MAP4K20.83420417
52MAP3K20.83389896
53TYRO30.83247938
54SGK4940.81014135
55SGK2230.81014135
56PAK30.80384177
57CDK11A0.78219477
58CSNK1G30.77139599
59STK110.75775254
60CAMK10.75492721
61OXSR10.74784380
62DYRK1A0.74021654
63NME10.71781831
64CSNK1A1L0.70798463
65SGK20.70006358
66GRK70.65944037
67PRKCH0.65898953
68SIK30.65151933
69CAMK1G0.64379931
70SGK10.62157733
71LMTK20.61914844
72PRKCE0.61764426
73WNK30.61716107
74MAPKAPK50.59561873
75CAMK2D0.59033872
76WNK40.58703550
77BMPR20.58623265
78RAF10.58498416
79MAP3K60.57756447
80PTK2B0.56831005
81TNK20.53178037
82FGR0.52751508
83STK390.51407863
84CAMK40.51114817
85PRKCZ0.50875063
86PINK10.49804210
87FER0.49002527
88CAMK2G0.48226729
89CSNK1D0.47921807
90SGK30.47717746
91AKT30.46179751
92MARK20.44757325
93FYN0.44625859
94MAP3K10.44318525
95MKNK20.43998782
96BCR0.43891130
97PRKG10.43325767
98RPS6KA30.42846251
99ALK0.42746283
100CSNK1E0.42338009
101PDK10.42039145
102TAOK10.41555947
103PRKACA0.39769607
104ADRBK20.39654491
105SCYL20.39621618
106CSNK1G10.39525044
107MAPK100.39025051
108WNK10.38968582
109PKN10.38965247
110PRKACB0.38828122
111ROCK20.38539963
112MAP2K10.38532584
113ERBB40.38295639
114ERBB30.37952006
115ADRBK10.37745884
116INSRR0.37437317
117GRK10.37155824
118CSNK1A10.33645982
119PRKCB0.32120677
120MAPK120.31889054
121MAP2K60.29595679
122PRKCA0.29567171
123LIMK10.26808815

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14903443
2Synaptic vesicle cycle_Homo sapiens_hsa047213.79051412
3GABAergic synapse_Homo sapiens_hsa047272.89221886
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79358081
5Amphetamine addiction_Homo sapiens_hsa050312.55702453
6Circadian entrainment_Homo sapiens_hsa047132.53523212
7Olfactory transduction_Homo sapiens_hsa047402.51796706
8Long-term potentiation_Homo sapiens_hsa047202.51553925
9Morphine addiction_Homo sapiens_hsa050322.49854259
10Glutamatergic synapse_Homo sapiens_hsa047242.46124984
11Dopaminergic synapse_Homo sapiens_hsa047282.32130149
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17344584
13Cocaine addiction_Homo sapiens_hsa050302.09909128
14Collecting duct acid secretion_Homo sapiens_hsa049662.06178652
15Salivary secretion_Homo sapiens_hsa049702.02136698
16Taste transduction_Homo sapiens_hsa047421.94182390
17Cholinergic synapse_Homo sapiens_hsa047251.92220974
18Insulin secretion_Homo sapiens_hsa049111.91672611
19Serotonergic synapse_Homo sapiens_hsa047261.91516928
20Long-term depression_Homo sapiens_hsa047301.74068421
21Gastric acid secretion_Homo sapiens_hsa049711.72787096
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63910994
23Renin secretion_Homo sapiens_hsa049241.62892228
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55727659
25Calcium signaling pathway_Homo sapiens_hsa040201.54196840
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53697506
27Oxytocin signaling pathway_Homo sapiens_hsa049211.48124518
28Gap junction_Homo sapiens_hsa045401.34711495
29GnRH signaling pathway_Homo sapiens_hsa049121.32634950
30Vibrio cholerae infection_Homo sapiens_hsa051101.31197063
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28452187
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27838486
33Cardiac muscle contraction_Homo sapiens_hsa042601.24880861
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18707945
35Estrogen signaling pathway_Homo sapiens_hsa049151.14319655
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13630050
37Oxidative phosphorylation_Homo sapiens_hsa001901.11140030
38cAMP signaling pathway_Homo sapiens_hsa040241.10516764
39Axon guidance_Homo sapiens_hsa043601.09917186
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.09036495
41Type II diabetes mellitus_Homo sapiens_hsa049301.05427583
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03700075
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00535943
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99664650
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97912288
46ErbB signaling pathway_Homo sapiens_hsa040120.95926028
47Melanogenesis_Homo sapiens_hsa049160.95018029
48Parkinsons disease_Homo sapiens_hsa050120.94935346
49Alzheimers disease_Homo sapiens_hsa050100.94407022
50Glioma_Homo sapiens_hsa052140.93234983
51Phototransduction_Homo sapiens_hsa047440.88242509
52Vitamin B6 metabolism_Homo sapiens_hsa007500.85621488
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85354967
54Type I diabetes mellitus_Homo sapiens_hsa049400.83835187
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.81796106
56Oocyte meiosis_Homo sapiens_hsa041140.77924885
57Dorso-ventral axis formation_Homo sapiens_hsa043200.76099116
58Pancreatic secretion_Homo sapiens_hsa049720.73548458
59Thyroid hormone synthesis_Homo sapiens_hsa049180.71073752
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.68970153
61Alcoholism_Homo sapiens_hsa050340.67181800
62Dilated cardiomyopathy_Homo sapiens_hsa054140.62371408
63MAPK signaling pathway_Homo sapiens_hsa040100.61851661
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61469185
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58227061
66Choline metabolism in cancer_Homo sapiens_hsa052310.57850524
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54435962
68Huntingtons disease_Homo sapiens_hsa050160.53432492
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53044981
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52920434
71Glucagon signaling pathway_Homo sapiens_hsa049220.52285388
72Ras signaling pathway_Homo sapiens_hsa040140.50100365
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49633221
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49613059
75Butanoate metabolism_Homo sapiens_hsa006500.47662004
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.46967768
77African trypanosomiasis_Homo sapiens_hsa051430.45334189
78Rap1 signaling pathway_Homo sapiens_hsa040150.44607400
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44249070
80Regulation of autophagy_Homo sapiens_hsa041400.43803563
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.42961100
82Rheumatoid arthritis_Homo sapiens_hsa053230.42833158
83Inositol phosphate metabolism_Homo sapiens_hsa005620.42465304
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40865684
85Protein export_Homo sapiens_hsa030600.39905803
86VEGF signaling pathway_Homo sapiens_hsa043700.38251117
87Prion diseases_Homo sapiens_hsa050200.38031890
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37431472
89Endocytosis_Homo sapiens_hsa041440.36620852
90Wnt signaling pathway_Homo sapiens_hsa043100.36341855
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36256524
92Ether lipid metabolism_Homo sapiens_hsa005650.35730717
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35715378
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35066514
95Bile secretion_Homo sapiens_hsa049760.34075178
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33383310
97Insulin signaling pathway_Homo sapiens_hsa049100.33355157
98Circadian rhythm_Homo sapiens_hsa047100.32895273
99Renal cell carcinoma_Homo sapiens_hsa052110.32891909
100Tight junction_Homo sapiens_hsa045300.32680048
101Endometrial cancer_Homo sapiens_hsa052130.32662110
102Hippo signaling pathway_Homo sapiens_hsa043900.30253718
103mTOR signaling pathway_Homo sapiens_hsa041500.29793400
104Nitrogen metabolism_Homo sapiens_hsa009100.29633372
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28590530
106Ovarian steroidogenesis_Homo sapiens_hsa049130.28557484
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28557099
108Fatty acid biosynthesis_Homo sapiens_hsa000610.28342839
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28275420
110Phagosome_Homo sapiens_hsa041450.27276043
111Mineral absorption_Homo sapiens_hsa049780.25591914
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25302311
113Hedgehog signaling pathway_Homo sapiens_hsa043400.24989919
114Folate biosynthesis_Homo sapiens_hsa007900.23389427
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20679012
116Prolactin signaling pathway_Homo sapiens_hsa049170.19633277

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