RAB3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.00463744
2COPI coating of Golgi vesicle (GO:0048205)9.00463744
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.06590845
4protein retention in ER lumen (GO:0006621)7.71769427
5exocrine pancreas development (GO:0031017)6.52973568
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.88673921
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.88673921
8modulation by symbiont of host immune response (GO:0052553)5.88673921
9positive regulation by symbiont of host defense response (GO:0052509)5.88673921
10modulation by symbiont of host defense response (GO:0052031)5.88673921
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.88673921
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.47133443
13signal peptide processing (GO:0006465)5.36822301
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.34719933
15neutrophil activation (GO:0042119)5.16866628
16detection of other organism (GO:0098543)5.16351697
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.11306884
18negative regulation of cell killing (GO:0031342)5.11306884
19detection of bacterium (GO:0016045)4.93558305
20sequestering of metal ion (GO:0051238)4.81229771
21activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.80302771
22intestinal cholesterol absorption (GO:0030299)4.80289788
23protein maturation by protein folding (GO:0022417)4.78466699
24COPII vesicle coating (GO:0048208)4.72530299
25leukocyte migration involved in inflammatory response (GO:0002523)4.64929803
26endocrine pancreas development (GO:0031018)4.62898227
27mitochondrial calcium ion transport (GO:0006851)4.57717830
28positive regulation of nuclease activity (GO:0032075)4.57506913
29keratinocyte development (GO:0003334)4.53415913
30glandular epithelial cell differentiation (GO:0002067)4.46948515
31macrophage activation involved in immune response (GO:0002281)4.42981352
32digestion (GO:0007586)4.40799353
33microglial cell activation (GO:0001774)4.36694905
34granulocyte activation (GO:0036230)4.35175723
35ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.35077065
36regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.33007833
37detection of external biotic stimulus (GO:0098581)4.28634818
38response to host immune response (GO:0052572)4.27076299
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.27076299
40leukocyte aggregation (GO:0070486)4.17975588
41regulation of nuclease activity (GO:0032069)4.15608448
42endoplasmic reticulum unfolded protein response (GO:0030968)4.15183587
43peptide hormone processing (GO:0016486)4.13721875
44detection of molecule of bacterial origin (GO:0032490)4.11552184
45cellular response to unfolded protein (GO:0034620)4.05729185
46respiratory burst (GO:0045730)4.03881208
47regulation of B cell receptor signaling pathway (GO:0050855)4.00556603
48regulation of interferon-beta biosynthetic process (GO:0045357)3.98531482
49regulation of type B pancreatic cell apoptotic process (GO:2000674)3.96462809
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.95760742
51cellular response to topologically incorrect protein (GO:0035967)3.95482427
52positive regulation of gamma-delta T cell activation (GO:0046645)3.95416679
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.92662452
54cellular extravasation (GO:0045123)3.92065252
55ER-nucleus signaling pathway (GO:0006984)3.88389103
56intestinal epithelial cell development (GO:0060576)3.86530397
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.83706089
58desmosome organization (GO:0002934)3.82345467
59macrophage activation (GO:0042116)3.78007425
60transcytosis (GO:0045056)3.77585192
61type B pancreatic cell development (GO:0003323)3.75312108
62response to host (GO:0075136)3.64805532
63response to host defenses (GO:0052200)3.64805532
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.64805532
65detection of biotic stimulus (GO:0009595)3.63363680
66protein N-linked glycosylation via asparagine (GO:0018279)3.61131163
67response to endoplasmic reticulum stress (GO:0034976)3.61015388
68positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.58862124
69vesicle coating (GO:0006901)3.58340836
70peptidyl-asparagine modification (GO:0018196)3.58109122
71negative regulation of phagocytosis (GO:0050765)3.56944083
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.56079568
73ER overload response (GO:0006983)3.53777626
74intestinal absorption (GO:0050892)3.50825100
75myeloid cell activation involved in immune response (GO:0002275)3.49023989
76leukocyte degranulation (GO:0043299)3.45447038
77cellular response to interleukin-15 (GO:0071350)3.43932507
78hepatocyte apoptotic process (GO:0097284)3.43841505
79columnar/cuboidal epithelial cell development (GO:0002066)3.41970567
80sphingosine metabolic process (GO:0006670)3.41133113
81interleukin-1-mediated signaling pathway (GO:0070498)3.39404254
82glandular epithelial cell development (GO:0002068)3.37121896
83UDP-N-acetylglucosamine metabolic process (GO:0006047)3.36306430
84regulation of water loss via skin (GO:0033561)3.33601327
85negative regulation of glycoprotein biosynthetic process (GO:0010561)3.31403845
86response to interleukin-15 (GO:0070672)3.27687166
87protein N-linked glycosylation (GO:0006487)3.25972393
88negative regulation of T cell mediated immunity (GO:0002710)3.24108789
89diol metabolic process (GO:0034311)3.23925729
90dendritic cell migration (GO:0036336)3.23153423
91negative regulation of interleukin-12 production (GO:0032695)3.22194568
92regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.20151251
93sphingoid metabolic process (GO:0046519)3.18246984
94regulation of gamma-delta T cell activation (GO:0046643)3.17615110
95interferon-gamma secretion (GO:0072643)3.16755087
96negative regulation of leukocyte mediated immunity (GO:0002704)3.16538572
97valine metabolic process (GO:0006573)3.16330191
98negative regulation of T-helper cell differentiation (GO:0045623)3.15155082
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15155082
100peptide catabolic process (GO:0043171)3.14401277
101immunoglobulin mediated immune response (GO:0016064)3.11318736
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09524704
103GDP-mannose metabolic process (GO:0019673)3.08410335
104production of molecular mediator involved in inflammatory response (GO:0002532)3.06387162
105nucleoside diphosphate catabolic process (GO:0009134)3.06188852
106regulation of mast cell degranulation (GO:0043304)3.05445553
107regulation of mast cell activation (GO:0033003)3.05203630
108positive regulation of mast cell activation (GO:0033005)3.02322575
109eosinophil chemotaxis (GO:0048245)2.99277459
110neutrophil mediated immunity (GO:0002446)2.99112851
111response to unfolded protein (GO:0006986)2.98972167
112response to peptidoglycan (GO:0032494)2.97583403
113ceramide catabolic process (GO:0046514)2.97105230
114fucose metabolic process (GO:0006004)2.96983537
115multicellular organismal water homeostasis (GO:0050891)2.94410309
116insulin secretion (GO:0030073)2.93178359
117establishment of skin barrier (GO:0061436)2.93062637
118negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91911192
119regulation of mast cell activation involved in immune response (GO:0033006)2.90879908
120response to topologically incorrect protein (GO:0035966)2.90626411
121positive regulation of insulin secretion (GO:0032024)2.90446321
122bundle of His cell to Purkinje myocyte communication (GO:0086069)2.88517409
123hemidesmosome assembly (GO:0031581)2.85914511
124regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85468782
125negative regulation of interleukin-1 production (GO:0032692)2.84940508
126ER to Golgi vesicle-mediated transport (GO:0006888)2.84717584
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84292117
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84292117
129adaptation of signaling pathway (GO:0023058)2.80248264
130regulation of Cdc42 GTPase activity (GO:0043088)2.79908796
131antigen processing and presentation via MHC class Ib (GO:0002475)2.79267297
132G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.78881783
133negative regulation of interleukin-6 production (GO:0032715)2.78434213
134maintenance of protein localization in organelle (GO:0072595)2.78402609
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77027410
136cellular response to vitamin D (GO:0071305)2.76803418
137neutrophil chemotaxis (GO:0030593)2.76627469
138leukotriene biosynthetic process (GO:0019370)2.76448366
139regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.75838288
140cell wall macromolecule catabolic process (GO:0016998)2.75589479
141eosinophil migration (GO:0072677)2.75287265
142positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75264265
143positive regulation of vesicle fusion (GO:0031340)2.75148930
144neutrophil activation involved in immune response (GO:0002283)2.75142096
145intra-Golgi vesicle-mediated transport (GO:0006891)2.73406272
146dendritic cell chemotaxis (GO:0002407)2.73022388
147regulation of interleukin-6 biosynthetic process (GO:0045408)2.72946196
148superoxide anion generation (GO:0042554)2.71857951
149membrane budding (GO:0006900)2.71739125
150regulation of leukocyte degranulation (GO:0043300)2.71254811
151neutrophil migration (GO:1990266)2.69434101
152regulation of interleukin-8 biosynthetic process (GO:0045414)2.69061057
153positive regulation of interferon-alpha production (GO:0032727)2.65340596
154regulated secretory pathway (GO:0045055)2.65302577
155Golgi organization (GO:0007030)2.63453949
156regulation of phospholipase A2 activity (GO:0032429)2.62181722
157glucosamine-containing compound catabolic process (GO:1901072)2.60940311
158activated T cell proliferation (GO:0050798)2.60910771
159regulation of gamma-delta T cell differentiation (GO:0045586)2.58857739
160negative regulation of B cell mediated immunity (GO:0002713)2.58599777
161negative regulation of immunoglobulin mediated immune response (GO:0002890)2.58599777
162negative regulation of adaptive immune response (GO:0002820)2.58248277
163membrane lipid catabolic process (GO:0046466)2.57953235
164reactive oxygen species biosynthetic process (GO:1903409)2.57780867
165myeloid leukocyte activation (GO:0002274)2.55627079
166phagosome maturation (GO:0090382)2.55299211
167hydrogen peroxide biosynthetic process (GO:0050665)2.54544171
168leukotriene metabolic process (GO:0006691)2.54300362
169gland morphogenesis (GO:0022612)2.54171196
170negative regulation of execution phase of apoptosis (GO:1900118)2.54085040
171glycolipid catabolic process (GO:0019377)2.54039231
172phospholipid scrambling (GO:0017121)2.52609219
173water homeostasis (GO:0030104)2.52308244
174regulation of insulin secretion (GO:0050796)2.52124263
175antigen processing and presentation of endogenous antigen (GO:0019883)2.49830774
176positive regulation of Cdc42 GTPase activity (GO:0043089)2.49150533
177zinc ion transport (GO:0006829)2.49010734
178cellular response to nicotine (GO:0071316)2.45303797
179cellular response to vitamin (GO:0071295)2.45169517
180cellular response to antibiotic (GO:0071236)2.44171197
181phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43587344
182negative regulation of glycoprotein metabolic process (GO:1903019)2.43362206
183norepinephrine metabolic process (GO:0042415)2.42349811
184epithelial cell maturation (GO:0002070)2.41900741
185growth hormone receptor signaling pathway (GO:0060396)2.38348574
186myeloid leukocyte mediated immunity (GO:0002444)2.38085608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.38072340
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.42004854
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.71122036
4GATA1_22025678_ChIP-Seq_K562_Human3.61083752
5STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.97046297
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.64712756
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.52156243
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16522539
9* SOX2_20726797_ChIP-Seq_SW620_Human2.14418103
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.09307834
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08928355
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04443585
13RUNX_20019798_ChIP-Seq_JUKART_Human1.98986860
14GATA4_25053715_ChIP-Seq_YYC3_Human1.98564883
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.96701132
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95488571
17P63_26484246_Chip-Seq_KERATINOCYTES_Human1.95353039
18AHR_22903824_ChIP-Seq_MCF-7_Human1.93525185
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92752981
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92315798
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91836210
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89155886
23ER_23166858_ChIP-Seq_MCF-7_Human1.88319433
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75961990
25FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74582970
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.74299185
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73979464
28SCL_19346495_ChIP-Seq_HPC-7_Human1.72703032
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.64223357
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63381047
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62646439
32* VDR_24787735_ChIP-Seq_THP-1_Human1.62255364
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.60375304
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.58848941
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58800381
36* GATA6_25053715_ChIP-Seq_YYC3_Human1.57985872
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57173486
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.55372020
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55224102
40ZNF274_21170338_ChIP-Seq_K562_Hela1.54654555
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54475869
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53987905
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52978168
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.52352598
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47934544
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40999682
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40961349
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40639337
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38205207
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37874120
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37616154
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36919544
53MYB_26560356_Chip-Seq_TH1_Human1.36180883
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.35598503
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34401193
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32881832
57CLOCK_20551151_ChIP-Seq_293T_Human1.32753764
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31795043
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31224810
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29812463
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29271821
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28059066
63FOXA1_25552417_ChIP-Seq_VCAP_Human1.27449105
64ERG_20517297_ChIP-Seq_VCAP_Human1.25299337
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24899424
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.24868343
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22028580
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22028580
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20072074
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19878650
71* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19744332
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19627195
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19381729
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19341913
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.19097915
76* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18910912
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17821150
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16500867
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14860210
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14663738
81ELF5_23300383_ChIP-Seq_T47D_Human1.12088945
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12003320
83GATA3_27048872_Chip-Seq_THYMUS_Human1.11856596
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11274538
85CJUN_26792858_Chip-Seq_BT549_Human1.10496063
86TP63_23658742_ChIP-Seq_EP156T_Human1.10113384
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10017183
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09560965
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08500852
90* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08001694
91SPI1_23127762_ChIP-Seq_K562_Human1.07396733
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05232871
93* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04306592
94SMRT_27268052_Chip-Seq_Bcells_Human1.04192335
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03440804
96RACK7_27058665_Chip-Seq_MCF-7_Human1.03252637
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02146369
98MYB_26560356_Chip-Seq_TH2_Human1.01446959
99BCAT_22108803_ChIP-Seq_LS180_Human1.01286484
100UTX_26944678_Chip-Seq_JUKART_Human1.01211834
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01180809
102* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00838724
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00317077
104SPI1_23547873_ChIP-Seq_NB4_Human1.00310839
105POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99678985
106GATA3_21878914_ChIP-Seq_MCF-7_Human0.98370692
107GATA3_26560356_Chip-Seq_TH2_Human0.96557766
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96547895
109GATA2_19941826_ChIP-Seq_K562_Human0.96395356
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96149874
111BP1_19119308_ChIP-ChIP_Hs578T_Human0.95596666
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94823448
113ATF3_27146783_Chip-Seq_COLON_Human0.94451740
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93684189
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92794328
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92740370
117MAF_26560356_Chip-Seq_TH1_Human0.92309511
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91808766
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91677649
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91667053
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90906120
122LXR_22292898_ChIP-Seq_THP-1_Human0.90456336
123NANOG_20526341_ChIP-Seq_ESCs_Human0.90006732
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89827757
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89487289
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89171222
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89147119
128TP63_22573176_ChIP-Seq_HFKS_Human0.89120938
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88983376
130HOXB7_26014856_ChIP-Seq_BT474_Human0.88969977
131RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88952755
132GATA1_19941826_ChIP-Seq_K562_Human0.88910868
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88861675
134FOXA1_25329375_ChIP-Seq_VCAP_Human0.88861675
135* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87333210
136PU_27001747_Chip-Seq_BMDM_Mouse0.87284012
137AR_20517297_ChIP-Seq_VCAP_Human0.86862562
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86812831
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86810062
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86808366
141GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86661923
142TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86638883
143KLF5_25053715_ChIP-Seq_YYC3_Human0.86340477
144* GATA1_19941827_ChIP-Seq_MEL_Mouse0.86010321
145RUNX1_22412390_ChIP-Seq_EML_Mouse0.85492148
146ERA_21632823_ChIP-Seq_H3396_Human0.84824259
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84551590
148* VDR_24763502_ChIP-Seq_THP-1_Human0.84492751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.95068317
2MP0005220_abnormal_exocrine_pancreas3.56665280
3MP0010386_abnormal_urinary_bladder3.55577172
4MP0004381_abnormal_hair_follicle3.53615738
5MP0002693_abnormal_pancreas_physiology3.50672084
6MP0003183_abnormal_peptide_metabolism3.27589631
7MP0001666_abnormal_nutrient_absorption3.03118683
8MP0003191_abnormal_cellular_cholesterol2.98877345
9MP0010234_abnormal_vibrissa_follicle2.93005386
10MP0005075_abnormal_melanosome_morpholog2.73693282
11MP0001944_abnormal_pancreas_morphology2.72337837
12MP0004264_abnormal_extraembryonic_tissu2.71677597
13MP0003787_abnormal_imprinting2.70096824
14MP0005083_abnormal_biliary_tract2.55540976
15MP0005379_endocrine/exocrine_gland_phen2.41343182
16MP0002909_abnormal_adrenal_gland2.35199204
17MP0003300_gastrointestinal_ulcer2.12795504
18MP0003436_decreased_susceptibility_to2.00475348
19MP0009780_abnormal_chondrocyte_physiolo1.99997911
20MP0002796_impaired_skin_barrier1.99820919
21MP0008004_abnormal_stomach_pH1.99206375
22MP0000465_gastrointestinal_hemorrhage1.99156583
23MP0000427_abnormal_hair_cycle1.97161738
24MP0000678_abnormal_parathyroid_gland1.93968283
25MP0001800_abnormal_humoral_immune1.92956368
26MP0008260_abnormal_autophagy1.89138284
27MP0005310_abnormal_salivary_gland1.88847300
28MP0000013_abnormal_adipose_tissue1.83325579
29MP0002132_abnormal_respiratory_system1.79824847
30MP0010678_abnormal_skin_adnexa1.79343419
31MP0001986_abnormal_taste_sensitivity1.77094654
32MP0002420_abnormal_adaptive_immunity1.76010388
33MP0001819_abnormal_immune_cell1.74783216
34MP0006054_spinal_hemorrhage1.73362570
35MP0002837_dystrophic_cardiac_calcinosis1.73220053
36MP0000015_abnormal_ear_pigmentation1.72785050
37MP0002009_preneoplasia1.71597475
38MP0000613_abnormal_salivary_gland1.71544378
39MP0003868_abnormal_feces_composition1.70202368
40MP0002723_abnormal_immune_serum1.67589418
41MP0000569_abnormal_digit_pigmentation1.66791014
42MP0003283_abnormal_digestive_organ1.66019894
43MP0002452_abnormal_antigen_presenting1.59931377
44MP0005058_abnormal_lysosome_morphology1.57824700
45MP0004043_abnormal_pH_regulation1.56672835
46MP0005671_abnormal_response_to1.56512612
47MP0002078_abnormal_glucose_homeostasis1.55660880
48MP0005365_abnormal_bile_salt1.54109200
49MP0002638_abnormal_pupillary_reflex1.53412705
50MP0005275_abnormal_skin_tensile1.52317235
51MP0003724_increased_susceptibility_to1.50748209
52MP0005248_abnormal_Harderian_gland1.50019519
53MP0002060_abnormal_skin_morphology1.49498185
54MP0004883_abnormal_blood_vessel1.48655087
55MP0003011_delayed_dark_adaptation1.48209908
56MP0002148_abnormal_hypersensitivity_rea1.48187475
57MP0002876_abnormal_thyroid_physiology1.46051053
58MP0004782_abnormal_surfactant_physiolog1.45783453
59MP0001664_abnormal_digestion1.42699165
60MP0005174_abnormal_tail_pigmentation1.42414084
61MP0000383_abnormal_hair_follicle1.41412991
62MP0002166_altered_tumor_susceptibility1.40809683
63MP0000579_abnormal_nail_morphology1.39220222
64MP0004947_skin_inflammation1.36401998
65MP0003866_abnormal_defecation1.34963595
66MP0001765_abnormal_ion_homeostasis1.34913148
67MP0006082_CNS_inflammation1.34744248
68MP0008877_abnormal_DNA_methylation1.34338557
69MP0000538_abnormal_urinary_bladder1.32945606
70MP0003959_abnormal_lean_body1.30315061
71MP0000685_abnormal_immune_system1.29830215
72MP0009643_abnormal_urine_homeostasis1.29511562
73MP0002396_abnormal_hematopoietic_system1.28687439
74MP0003828_pulmonary_edema1.28252746
75MP0001756_abnormal_urination1.24864945
76MP0002098_abnormal_vibrissa_morphology1.22050597
77MP0001533_abnormal_skeleton_physiology1.21988693
78MP0004185_abnormal_adipocyte_glucose1.21485890
79MP0002163_abnormal_gland_morphology1.21014452
80MP0001216_abnormal_epidermal_layer1.19480411
81MP0003195_calcinosis1.19072391
82MP0005084_abnormal_gallbladder_morpholo1.18142963
83MP0001873_stomach_inflammation1.16571321
84MP0002405_respiratory_system_inflammati1.16174523
85MP0000003_abnormal_adipose_tissue1.15813207
86MP0000377_abnormal_hair_follicle1.15056553
87MP0000716_abnormal_immune_system1.14813060
88MP0001845_abnormal_inflammatory_respons1.13589988
89MP0003566_abnormal_cell_adhesion1.12110698
90MP0002398_abnormal_bone_marrow1.10219003
91MP0000516_abnormal_urinary_system1.09125017
92MP0005367_renal/urinary_system_phenotyp1.09125017
93MP0001835_abnormal_antigen_presentation1.08339021
94MP0004484_altered_response_of1.08172471
95MP0002006_tumorigenesis1.08043151
96MP0000689_abnormal_spleen_morphology1.07659304
97MP0002419_abnormal_innate_immunity1.07331285
98MP0000470_abnormal_stomach_morphology1.06060931
99MP0002653_abnormal_ependyma_morphology1.04692945
100MP0003953_abnormal_hormone_level1.04231772
101MP0010155_abnormal_intestine_physiology1.03425271
102MP0000681_abnormal_thyroid_gland1.00843757
103MP0005000_abnormal_immune_tolerance1.00615377
104MP0000858_altered_metastatic_potential0.99092916
105MP0001851_eye_inflammation0.99046904
106MP0009785_altered_susceptibility_to0.98596852
107MP0002254_reproductive_system_inflammat0.97883725
108MP0002138_abnormal_hepatobiliary_system0.97771527
109MP0002277_abnormal_respiratory_mucosa0.97719220
110MP0005408_hypopigmentation0.97057059
111MP0003045_fibrosis0.96251299
112MP0003303_peritoneal_inflammation0.95974796
113MP0002722_abnormal_immune_system0.95868641
114MP0002928_abnormal_bile_duct0.95065777
115MP0002896_abnormal_bone_mineralization0.94176284
116MP0005636_abnormal_mineral_homeostasis0.94073631
117MP0003453_abnormal_keratinocyte_physiol0.94049624
118MP0003943_abnormal_hepatobiliary_system0.93869179
119MP0005448_abnormal_energy_balance0.92589532
120MP0003763_abnormal_thymus_physiology0.92577051
121MP0008469_abnormal_protein_level0.92468927
122MP0005025_abnormal_response_to0.91925034
123MP0004858_abnormal_nervous_system0.90360776
124MP0001346_abnormal_lacrimal_gland0.90336064
125MP0003172_abnormal_lysosome_physiology0.87125298
126MP0005451_abnormal_body_composition0.83547371
127MP0009764_decreased_sensitivity_to0.83137383
128MP0001270_distended_abdomen0.82984989
129MP0005375_adipose_tissue_phenotype0.82973644
130MP0000703_abnormal_thymus_morphology0.81322992
131MP0003795_abnormal_bone_structure0.81011000
132MP0005535_abnormal_body_temperature0.80981338
133MP0002429_abnormal_blood_cell0.80320695
134MP0001881_abnormal_mammary_gland0.80260418
135MP0008961_abnormal_basal_metabolism0.79903364
136MP0005334_abnormal_fat_pad0.79890316
137MP0001545_abnormal_hematopoietic_system0.79834390
138MP0005397_hematopoietic_system_phenotyp0.79834390
139MP0005501_abnormal_skin_physiology0.78945524
140MP0005670_abnormal_white_adipose0.78031003
141MP0003121_genomic_imprinting0.77376740
142MP0000490_abnormal_crypts_of0.77284116
143MP0005076_abnormal_cell_differentiation0.76391346
144MP0005464_abnormal_platelet_physiology0.75793692
145MP0010771_integument_phenotype0.75129109
146MP0002118_abnormal_lipid_homeostasis0.73305252
147MP0005387_immune_system_phenotype0.73139227
148MP0001790_abnormal_immune_system0.73139227
149MP0009278_abnormal_bone_marrow0.72185062
150MP0005164_abnormal_response_to0.70736696
151MP0003878_abnormal_ear_physiology0.69633248
152MP0005377_hearing/vestibular/ear_phenot0.69633248
153MP0003638_abnormal_response/metabolism_0.69174369
154MP0002095_abnormal_skin_pigmentation0.67913105
155MP0001919_abnormal_reproductive_system0.67335512
156MP0008995_early_reproductive_senescence0.66750713

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.90822462
2Hypochromic microcytic anemia (HP:0004840)4.70156719
3Insulin-resistant diabetes mellitus (HP:0000831)4.62401841
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.54545518
5Hyperinsulinemic hypoglycemia (HP:0000825)4.53350562
6Hypoglycemic seizures (HP:0002173)4.50477333
7Orchitis (HP:0100796)4.44962211
8Hypoglycemic coma (HP:0001325)4.43208821
9Symptomatic seizures (HP:0011145)4.40955947
10Urinary glycosaminoglycan excretion (HP:0003541)4.29587588
11Mucopolysacchariduria (HP:0008155)4.29587588
12Retrobulbar optic neuritis (HP:0100654)4.16604259
13Optic neuritis (HP:0100653)4.16604259
14Vacuolated lymphocytes (HP:0001922)4.15424051
15Abnormality of macrophages (HP:0004311)4.07622889
16Dysostosis multiplex (HP:0000943)4.07473230
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.98442845
18Abnormality of polysaccharide metabolism (HP:0011012)3.98442845
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.98442845
20Hypothermia (HP:0002045)3.82084392
21Elevated erythrocyte sedimentation rate (HP:0003565)3.76543316
22Hyperglycemia (HP:0003074)3.53077551
23Recurrent skin infections (HP:0001581)3.45536511
24Hypochromic anemia (HP:0001931)3.45515023
25Eczematoid dermatitis (HP:0000976)3.42465969
26Generalized aminoaciduria (HP:0002909)3.23592033
27Urticaria (HP:0001025)3.21229269
28Gastrointestinal infarctions (HP:0005244)3.21108945
29Abnormality of calcium-phosphate metabolism (HP:0100530)3.21007977
30Exocrine pancreatic insufficiency (HP:0001738)3.20779077
31Recurrent fungal infections (HP:0002841)3.16828939
32Abnormal pancreas size (HP:0012094)3.12494984
33Late onset (HP:0003584)3.10208890
34Thoracolumbar scoliosis (HP:0002944)3.08876592
35Ketoacidosis (HP:0001993)3.08137090
36Keratoconjunctivitis sicca (HP:0001097)3.00966627
37Abnormality of the pancreatic islet cells (HP:0006476)2.99290808
38Abnormality of endocrine pancreas physiology (HP:0012093)2.99290808
39Abnormality of the intrinsic pathway (HP:0010989)2.98673437
40Right ventricular cardiomyopathy (HP:0011663)2.95171633
41Recurrent abscess formation (HP:0002722)2.89832720
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88839154
43Abnormal protein N-linked glycosylation (HP:0012347)2.88839154
44Abnormal protein glycosylation (HP:0012346)2.88839154
45Abnormal glycosylation (HP:0012345)2.88839154
46Keratoconjunctivitis (HP:0001096)2.88511457
47Lip pit (HP:0100267)2.86218819
48Large for gestational age (HP:0001520)2.84097001
49Prolonged bleeding time (HP:0003010)2.80462506
50Chronic obstructive pulmonary disease (HP:0006510)2.77057341
51Obstructive lung disease (HP:0006536)2.77057341
52Encephalitis (HP:0002383)2.74883235
53Recurrent bacterial skin infections (HP:0005406)2.71337619
54Hyperparathyroidism (HP:0000843)2.69525246
55Amelogenesis imperfecta (HP:0000705)2.66231814
56Decreased circulating renin level (HP:0003351)2.64338537
57Meningitis (HP:0001287)2.63530018
58Chest pain (HP:0100749)2.61464991
59Insulin resistance (HP:0000855)2.61462622
60Plantar hyperkeratosis (HP:0007556)2.61245786
61Gingival bleeding (HP:0000225)2.60653617
62Hyperphosphatemia (HP:0002905)2.57981096
63Onycholysis (HP:0001806)2.56512440
64Recurrent cutaneous fungal infections (HP:0011370)2.55142009
65Chronic mucocutaneous candidiasis (HP:0002728)2.55142009
66Abnormality of liposaccharide metabolism (HP:0010968)2.54275418
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.54275418
68Abnormality of glycolipid metabolism (HP:0010969)2.54275418
69Type I transferrin isoform profile (HP:0003642)2.49738102
70Concave nail (HP:0001598)2.49592464
71Anorexia (HP:0002039)2.48440367
72Papilledema (HP:0001085)2.47596161
73Increased IgE level (HP:0003212)2.46309719
74Pancreatic islet-cell hyperplasia (HP:0004510)2.38694120
75Arterial thrombosis (HP:0004420)2.37277179
76Vasculitis (HP:0002633)2.36846081
77Abnormality of nail color (HP:0100643)2.36135908
78Hamartoma of the eye (HP:0010568)2.32903660
79Gangrene (HP:0100758)2.31025489
80Pancreatitis (HP:0001733)2.29557202
81Microcytic anemia (HP:0001935)2.29498626
82Testicular neoplasm (HP:0010788)2.27979809
83Mediastinal lymphadenopathy (HP:0100721)2.27669386
84Periodontitis (HP:0000704)2.27119732
85Interstitial pulmonary disease (HP:0006530)2.26673764
86Spontaneous hematomas (HP:0007420)2.25943791
87Conjunctival hamartoma (HP:0100780)2.24791972
88Hemoptysis (HP:0002105)2.24702305
89Progressive neurologic deterioration (HP:0002344)2.22225399
90Stomach cancer (HP:0012126)2.20871320
91Hyperactive renin-angiotensin system (HP:0000841)2.19022005
92Aqueductal stenosis (HP:0002410)2.18798314
93Petechiae (HP:0000967)2.18058688
94Pustule (HP:0200039)2.18028487
95Unilateral renal agenesis (HP:0000122)2.17655389
96Cheilitis (HP:0100825)2.16611084
97Abdominal distention (HP:0003270)2.16277936
98Palmoplantar hyperkeratosis (HP:0000972)2.16243780
99Retinal atrophy (HP:0001105)2.15625750
100Amyloidosis (HP:0011034)2.14656138
101Decreased subcutaneous fat (HP:0001002)2.14222354
102Type I diabetes mellitus (HP:0100651)2.13882763
103Growth hormone excess (HP:0000845)2.12437493
104Abnormality of the axillary hair (HP:0100134)2.07803536
105Abnormality of secondary sexual hair (HP:0009888)2.07803536
106Dysautonomia (HP:0002459)2.07030051
107Hypokalemia (HP:0002900)2.06997142
108Neoplasm of the adrenal cortex (HP:0100641)2.06043097
109Muscle fibrillation (HP:0010546)2.05821265
110Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05604427
111Hypercortisolism (HP:0001578)2.03951158
112Leukocytosis (HP:0001974)2.03316956
113Milia (HP:0001056)2.03104951
114Popliteal pterygium (HP:0009756)2.03086071
115Gingivitis (HP:0000230)2.02062961
116Hypotension (HP:0002615)2.01830877
117Abnormal rod and cone electroretinograms (HP:0008323)2.01596730
118Sepsis (HP:0100806)2.00962886
119Recurrent gram-negative bacterial infections (HP:0005420)2.00651629
120Woolly hair (HP:0002224)1.98254481
121Abnormality of the common coagulation pathway (HP:0010990)1.94017548
122Abnormality of small intestinal villus morphology (HP:0011472)1.92303008
123Villous atrophy (HP:0011473)1.92303008
124Palmar hyperkeratosis (HP:0010765)1.92043293
125Episodic fever (HP:0001954)1.91371473
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.91317380
127Increased cerebral lipofuscin (HP:0011813)1.90692742
128Pulmonary embolism (HP:0002204)1.89693974
129Oligomenorrhea (HP:0000876)1.88719404
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.88707206
131Beaking of vertebral bodies (HP:0004568)1.86780488
132Abnormality of subcutaneous fat tissue (HP:0001001)1.86497469
133Progressive inability to walk (HP:0002505)1.85693563
134Breast carcinoma (HP:0003002)1.85520272
135Conjugated hyperbilirubinemia (HP:0002908)1.83394451
136Parakeratosis (HP:0001036)1.82645875
137Agitation (HP:0000713)1.82512647
138Hypotrichosis (HP:0001006)1.80723256
139Keratitis (HP:0000491)1.80545463
140Osteomyelitis (HP:0002754)1.80471889
141Limb hypertonia (HP:0002509)1.79798948
142Neoplasm of the tracheobronchial system (HP:0100552)1.79614306
143Congenital ichthyosiform erythroderma (HP:0007431)1.79078119
144Curly hair (HP:0002212)1.77197377
145Abnormal delayed hypersensitivity skin test (HP:0002963)1.77142856
146Thoracic kyphosis (HP:0002942)1.75640257
147Gout (HP:0001997)1.74459754
148Epistaxis (HP:0000421)1.73492053
149Macroorchidism (HP:0000053)1.73105292
150Cone-rod dystrophy (HP:0000548)1.73100943
151Bone cyst (HP:0012062)1.72683568
152Hypoplasia of dental enamel (HP:0006297)1.72492707
153Pancreatic cysts (HP:0001737)1.72200109
154Micronodular cirrhosis (HP:0001413)1.72107386
155Myositis (HP:0100614)1.71409392
156Reduced antithrombin III activity (HP:0001976)1.71257501
157Steatorrhea (HP:0002570)1.71004832
158Furrowed tongue (HP:0000221)1.70835379
159Abnormality of chloride homeostasis (HP:0011422)1.70608571
160Premature loss of primary teeth (HP:0006323)1.69698486
161Acute hepatic failure (HP:0006554)1.69680771
162Abnormality of T cell physiology (HP:0011840)1.69332133
163Hypoplasia of the odontoid process (HP:0003311)1.67372691
164Abnormality of the gastric mucosa (HP:0004295)1.66570472
165Congenital sensorineural hearing impairment (HP:0008527)1.66539505
166Fat malabsorption (HP:0002630)1.65706305
167Ventricular fibrillation (HP:0001663)1.65233623
168Widely spaced teeth (HP:0000687)1.65089823
169Erythroderma (HP:0001019)1.64283299
170Alveolar cell carcinoma (HP:0006519)1.62879629
171Pulmonary infiltrates (HP:0002113)1.62834595
172Hyperventilation (HP:0002883)1.62599606
173Papillary thyroid carcinoma (HP:0002895)1.62018593
174Macular degeneration (HP:0000608)1.62007948
175Increased CSF protein (HP:0002922)1.61936074
176Choroideremia (HP:0001139)1.61450869
177Skin ulcer (HP:0200042)1.58287714
178Erythema (HP:0010783)1.57327506
179Abnormality of the pleura (HP:0002103)1.56618507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.52761045
2ERN14.44660569
3TAOK34.31397850
4FRK3.28062314
5TNK23.26251454
6SIK32.99241557
7MAPKAPK32.93464714
8MAP3K22.83362195
9BCKDK2.81088914
10GRK62.65851316
11PASK2.60218069
12IRAK32.58748619
13MAPK152.43619214
14TRIM282.06178441
15IRAK42.06175185
16TRIB32.03770790
17EPHA31.91865271
18MAP4K11.91408373
19TAOK11.88964070
20HIPK21.86662118
21FES1.85637679
22MAP3K31.83206714
23MAP2K21.81738641
24YES11.80112070
25MST1R1.75242915
26FLT31.66959790
27NTRK11.58475565
28MAP3K11.53026442
29FGR1.45486184
30EIF2AK31.42759622
31NUAK11.41760355
32PIK3CG1.41059852
33TRPM71.36702853
34JAK31.36474645
35ZAP701.34327185
36HCK1.32956961
37MST41.31566734
38PTK2B1.23071456
39EEF2K1.20933742
40FGFR21.20645497
41PTK61.16220035
42CSF1R1.16161745
43FER1.14848608
44LATS11.13059675
45OXSR11.11038950
46MAP3K141.09466556
47PAK31.08449699
48MATK1.07621052
49SIK11.05316869
50DAPK21.04110832
51PIM21.03514811
52GRK11.03286450
53AKT31.02602374
54RPS6KA21.01561459
55TESK11.01471489
56JAK20.99674217
57RET0.99167319
58JAK10.99116852
59ACVR1B0.99016141
60RIPK40.98786915
61BMPR20.98268687
62MAPK130.97956423
63KIT0.96348734
64LYN0.93051184
65TYK20.92313261
66TXK0.91766118
67PTK20.91529653
68IRAK10.90602320
69TEC0.89482421
70MAP2K10.89024860
71CAMKK20.87617436
72MAP2K30.87548913
73BTK0.86528025
74MARK30.84469012
75MAP2K40.82969421
76TBK10.81758059
77MAP4K20.80772511
78KSR20.79798626
79SGK20.79266344
80WNK30.79058884
81FGFR30.78871241
82STK110.78072283
83NME20.77650096
84BLK0.76622023
85SCYL20.74767842
86STK240.74289749
87STK100.73469427
88LRRK20.72788599
89MET0.68829263
90SGK30.68742276
91PDGFRA0.68416972
92PDK10.67846998
93LCK0.65551488
94WNK40.65230153
95EPHB10.65152101
96DYRK30.63542718
97PRKCZ0.63431953
98BMPR1B0.63249889
99RIPK10.61690024
100BRAF0.60698301
101PKN20.60000814
102ERBB30.59897109
103PRKD30.59158010
104MAP2K60.57396549
105TAF10.56804258
106PRKCI0.56386893
107NLK0.54630158
108CSK0.54496727
109PRKCQ0.53875689
110STK390.52927939
111NEK60.52125895
112RPS6KB10.51219113
113IKBKE0.50999189
114PRKG20.50794846
115MARK20.50705714
116FGFR40.48953397
117ARAF0.48311275
118DYRK1B0.47185257
119IRAK20.46330081
120TGFBR20.46289286
121MAP3K60.46091225
122MAP3K110.45585690
123PDPK10.45276777
124CHUK0.45243338
125MYLK0.45108779
126ITK0.44918925
127STK380.43282654
128PRKCH0.42699213
129PINK10.42570117
130LMTK20.40865168
131BCR0.38993268
132IGF1R0.38176647
133CASK0.37733152
134PDGFRB0.36639798
135SYK0.36541914
136RPS6KB20.36200506
137PRKCE0.35095924
138NEK90.34744970
139MAPKAPK20.34103588
140RPS6KC10.33841288
141RPS6KL10.33841288
142BRSK20.33448478
143IKBKB0.32405414
144RPS6KA60.31082219
145MAP3K120.30286278
146ADRBK10.27949983
147PRKD20.27831478

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.52972058
2Protein export_Homo sapiens_hsa030604.79095950
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.15768323
4* Pancreatic secretion_Homo sapiens_hsa049723.00468066
5Sulfur metabolism_Homo sapiens_hsa009202.74649947
6Other glycan degradation_Homo sapiens_hsa005112.49191928
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.16825664
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05237711
9N-Glycan biosynthesis_Homo sapiens_hsa005102.04550678
10Fat digestion and absorption_Homo sapiens_hsa049752.03620616
11Lysosome_Homo sapiens_hsa041421.90603955
12Vibrio cholerae infection_Homo sapiens_hsa051101.87538403
13Protein digestion and absorption_Homo sapiens_hsa049741.77113603
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70015872
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.69933170
16B cell receptor signaling pathway_Homo sapiens_hsa046621.68600437
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64217576
18Insulin secretion_Homo sapiens_hsa049111.62006126
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52597582
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40638685
21Dorso-ventral axis formation_Homo sapiens_hsa043201.40483104
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39362133
23Type II diabetes mellitus_Homo sapiens_hsa049301.37056590
24Type I diabetes mellitus_Homo sapiens_hsa049401.32574352
25Ether lipid metabolism_Homo sapiens_hsa005651.29942719
26T cell receptor signaling pathway_Homo sapiens_hsa046601.25856295
27Sphingolipid metabolism_Homo sapiens_hsa006001.24262431
28Legionellosis_Homo sapiens_hsa051341.21752537
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21630336
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.20208320
31Prolactin signaling pathway_Homo sapiens_hsa049171.18342041
32Leishmaniasis_Homo sapiens_hsa051401.17578700
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16118663
34Folate biosynthesis_Homo sapiens_hsa007901.15710764
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14944814
36Linoleic acid metabolism_Homo sapiens_hsa005911.08733593
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07535965
38Non-small cell lung cancer_Homo sapiens_hsa052231.07049014
39Endocytosis_Homo sapiens_hsa041441.06859661
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06556505
41Insulin resistance_Homo sapiens_hsa049311.05456951
42Graft-versus-host disease_Homo sapiens_hsa053321.03481369
43Inositol phosphate metabolism_Homo sapiens_hsa005621.01853440
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01750515
45Regulation of autophagy_Homo sapiens_hsa041401.01178837
46Renin-angiotensin system_Homo sapiens_hsa046141.00512035
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97239218
48Toxoplasmosis_Homo sapiens_hsa051450.95586124
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95276786
50Pertussis_Homo sapiens_hsa051330.95189429
51Glycerolipid metabolism_Homo sapiens_hsa005610.94781822
52Malaria_Homo sapiens_hsa051440.94577455
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93139727
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92756843
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88175205
56mTOR signaling pathway_Homo sapiens_hsa041500.86794792
57Thyroid cancer_Homo sapiens_hsa052160.86518860
58Allograft rejection_Homo sapiens_hsa053300.85784211
59Autoimmune thyroid disease_Homo sapiens_hsa053200.83822951
60Arachidonic acid metabolism_Homo sapiens_hsa005900.83242613
61Choline metabolism in cancer_Homo sapiens_hsa052310.83076395
62Primary immunodeficiency_Homo sapiens_hsa053400.82468186
63Phagosome_Homo sapiens_hsa041450.82237745
64Influenza A_Homo sapiens_hsa051640.81114431
65Tuberculosis_Homo sapiens_hsa051520.80210207
66Galactose metabolism_Homo sapiens_hsa000520.80043279
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78810310
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78559410
69African trypanosomiasis_Homo sapiens_hsa051430.74121798
70Phototransduction_Homo sapiens_hsa047440.73148197
71Starch and sucrose metabolism_Homo sapiens_hsa005000.73134269
72Renal cell carcinoma_Homo sapiens_hsa052110.72480097
73FoxO signaling pathway_Homo sapiens_hsa040680.72392759
74Histidine metabolism_Homo sapiens_hsa003400.72378694
75Collecting duct acid secretion_Homo sapiens_hsa049660.71900868
76Circadian rhythm_Homo sapiens_hsa047100.69609864
77Shigellosis_Homo sapiens_hsa051310.69305529
78Thyroid hormone synthesis_Homo sapiens_hsa049180.68707059
79Herpes simplex infection_Homo sapiens_hsa051680.68347542
80Rheumatoid arthritis_Homo sapiens_hsa053230.65720273
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65403752
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63806884
83ABC transporters_Homo sapiens_hsa020100.63122805
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.63072944
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62300231
86Hepatitis B_Homo sapiens_hsa051610.62202975
87Osteoclast differentiation_Homo sapiens_hsa043800.61536847
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61373147
89TNF signaling pathway_Homo sapiens_hsa046680.59083550
90Hepatitis C_Homo sapiens_hsa051600.58212134
91Endometrial cancer_Homo sapiens_hsa052130.57763234
92Pancreatic cancer_Homo sapiens_hsa052120.57562822
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57143948
94Amoebiasis_Homo sapiens_hsa051460.57141554
95Peroxisome_Homo sapiens_hsa041460.55561796
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54033086
97Phenylalanine metabolism_Homo sapiens_hsa003600.52819560
98Insulin signaling pathway_Homo sapiens_hsa049100.51157663
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50525392
100HIF-1 signaling pathway_Homo sapiens_hsa040660.49556777
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.49131916
102Long-term depression_Homo sapiens_hsa047300.48224647
103Bladder cancer_Homo sapiens_hsa052190.47930814
104Dopaminergic synapse_Homo sapiens_hsa047280.47879281
105VEGF signaling pathway_Homo sapiens_hsa043700.46818231
106GnRH signaling pathway_Homo sapiens_hsa049120.46273717
107Cocaine addiction_Homo sapiens_hsa050300.46016365
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.45523293
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44270260
110Chemokine signaling pathway_Homo sapiens_hsa040620.43967668
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43307409
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43281448
113Nitrogen metabolism_Homo sapiens_hsa009100.42562412
114Apoptosis_Homo sapiens_hsa042100.42504454
115Acute myeloid leukemia_Homo sapiens_hsa052210.42400668
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42133360
117Antigen processing and presentation_Homo sapiens_hsa046120.41800563
118Colorectal cancer_Homo sapiens_hsa052100.40770154
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.40106126
120Prostate cancer_Homo sapiens_hsa052150.39444113
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39243675
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38661320
123Platelet activation_Homo sapiens_hsa046110.38653064
124Estrogen signaling pathway_Homo sapiens_hsa049150.38095339
125Staphylococcus aureus infection_Homo sapiens_hsa051500.37996932
126Salmonella infection_Homo sapiens_hsa051320.37925506
127Selenocompound metabolism_Homo sapiens_hsa004500.34332202
128Measles_Homo sapiens_hsa051620.34018334
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32331974
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.31487136
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31476851
132Taste transduction_Homo sapiens_hsa047420.30634689
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.29977660
134Hematopoietic cell lineage_Homo sapiens_hsa046400.29934563
135Adherens junction_Homo sapiens_hsa045200.29681619
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.29589912
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29293603
138Mineral absorption_Homo sapiens_hsa049780.28219482
139Ovarian steroidogenesis_Homo sapiens_hsa049130.28037338
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27839598
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.27783943

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