RAB3GAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)9.80288478
2melanin metabolic process (GO:0006582)9.05876125
3secondary metabolite biosynthetic process (GO:0044550)7.93761600
4hemidesmosome assembly (GO:0031581)4.95556170
5COPII vesicle coating (GO:0048208)4.65828856
6desmosome organization (GO:0002934)4.54394446
7skin morphogenesis (GO:0043589)4.54040926
8Golgi transport vesicle coating (GO:0048200)4.38827050
9COPI coating of Golgi vesicle (GO:0048205)4.38827050
10cell adhesion mediated by integrin (GO:0033627)4.26220397
11developmental pigmentation (GO:0048066)4.23202399
12nuclear pore complex assembly (GO:0051292)4.16215475
13vesicle coating (GO:0006901)3.80166850
14phenol-containing compound biosynthetic process (GO:0046189)3.70547652
15* regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68927092
16cerebellar Purkinje cell differentiation (GO:0021702)3.66483701
17microtubule depolymerization (GO:0007019)3.51581465
18collagen fibril organization (GO:0030199)3.49608652
19cell-substrate junction assembly (GO:0007044)3.47786610
20nuclear pore organization (GO:0006999)3.44837596
21positive regulation of protein autophosphorylation (GO:0031954)3.43347374
22histone H3-K36 demethylation (GO:0070544)3.38786252
23nerve growth factor signaling pathway (GO:0038180)3.38622392
24tyrosine metabolic process (GO:0006570)3.37060738
25L-amino acid import (GO:0043092)3.28062465
26hypotonic response (GO:0006971)3.22938780
27regulation of early endosome to late endosome transport (GO:2000641)3.17164147
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14248305
29locomotory exploration behavior (GO:0035641)3.12980053
30sequestering of extracellular ligand from receptor (GO:0035581)3.10353999
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.04854607
32endodermal cell differentiation (GO:0035987)3.02419096
33cellular potassium ion homeostasis (GO:0030007)3.02196469
34neurotransmitter catabolic process (GO:0042135)2.98848861
35secondary metabolic process (GO:0019748)2.95996843
36mitotic sister chromatid cohesion (GO:0007064)2.93765495
37phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.90762779
38histone H3-K9 demethylation (GO:0033169)2.88345638
39regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.87879675
40ionotropic glutamate receptor signaling pathway (GO:0035235)2.83237204
41pigmentation (GO:0043473)2.82771146
42melanocyte differentiation (GO:0030318)2.82195092
43synaptic vesicle maturation (GO:0016188)2.81579573
44regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78922086
45regulation of glucocorticoid metabolic process (GO:0031943)2.78797962
46cellular response to vitamin D (GO:0071305)2.78751703
47bundle of His cell to Purkinje myocyte communication (GO:0086069)2.78748842
48pore complex assembly (GO:0046931)2.78496473
49positive regulation of receptor recycling (GO:0001921)2.78162465
50regulation of clathrin-mediated endocytosis (GO:2000369)2.77437451
51stress granule assembly (GO:0034063)2.77229505
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76903909
53endocytic recycling (GO:0032456)2.75444393
54neuronal action potential propagation (GO:0019227)2.72219928
55negative regulation of anoikis (GO:2000811)2.72027836
56import into cell (GO:0098657)2.70492464
57gamma-aminobutyric acid signaling pathway (GO:0007214)2.69514678
58wound healing, spreading of epidermal cells (GO:0035313)2.69410552
59neuron-neuron synaptic transmission (GO:0007270)2.68647310
60glutamate receptor signaling pathway (GO:0007215)2.67727652
61labyrinthine layer development (GO:0060711)2.66952601
62Golgi to endosome transport (GO:0006895)2.66060266
63regulation of mRNA 3-end processing (GO:0031440)2.65887497
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.65830909
65regulation of synaptic vesicle exocytosis (GO:2000300)2.65565176
66regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65006869
67protein localization to cell surface (GO:0034394)2.64178266
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62806120
69protein localization to endosome (GO:0036010)2.61433556
70regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61326994
71chondrocyte development (GO:0002063)2.59467112
72negative regulation of protein localization to plasma membrane (GO:1903077)2.59443330
73activation of protein kinase A activity (GO:0034199)2.59022143
74cortical actin cytoskeleton organization (GO:0030866)2.58641364
75cell differentiation in hindbrain (GO:0021533)2.58514423
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.58224479
77negative regulation of neurotransmitter transport (GO:0051589)2.57748583
78smooth muscle tissue development (GO:0048745)2.57284940
79positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.57145595
80regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.57145595
81epithelial cell-cell adhesion (GO:0090136)2.56750035
82prepulse inhibition (GO:0060134)2.56448217
83plasma membrane repair (GO:0001778)2.55543744
84phosphatidylinositol dephosphorylation (GO:0046856)2.55235905
85negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.54695525
86protein targeting to Golgi (GO:0000042)2.54252590
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52702742
88suckling behavior (GO:0001967)2.52511424
89negative regulation of keratinocyte proliferation (GO:0010839)2.51753906
90histone H3-K4 trimethylation (GO:0080182)2.51573336
91clathrin coat assembly (GO:0048268)2.51351457
92regulation of transforming growth factor beta1 production (GO:0032908)2.51160749
93sodium ion export (GO:0071436)2.51053268
94long-chain fatty acid biosynthetic process (GO:0042759)2.50788580
95positive regulation of cellular response to insulin stimulus (GO:1900078)2.49430335
96stress fiber assembly (GO:0043149)2.49334229
97platelet-derived growth factor receptor signaling pathway (GO:0048008)2.48997905
98vesicle transport along microtubule (GO:0047496)2.48703081
99synaptic transmission, glutamatergic (GO:0035249)2.47811465
100cellular response to vitamin (GO:0071295)2.47672524
101G-protein coupled receptor internalization (GO:0002031)2.47664323
102protein hydroxylation (GO:0018126)2.47325796
103glycine transport (GO:0015816)2.47191990
104cell-substrate adherens junction assembly (GO:0007045)2.46321325
105focal adhesion assembly (GO:0048041)2.46321325
106positive regulation of mRNA 3-end processing (GO:0031442)2.46122986
107neuromuscular process controlling posture (GO:0050884)2.45565476
108potassium ion homeostasis (GO:0055075)2.45531529
109Golgi organization (GO:0007030)2.45404481
110pre-miRNA processing (GO:0031054)2.44987955
111positive regulation of macroautophagy (GO:0016239)2.44932142
112regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44820951
113regulation of ARF protein signal transduction (GO:0032012)2.44632159
114transmission of nerve impulse (GO:0019226)2.44379345
115insulin secretion (GO:0030073)2.44260682
116potassium ion import (GO:0010107)2.42124322
117regulation of glutamate receptor signaling pathway (GO:1900449)2.41770989
118histone lysine demethylation (GO:0070076)2.40725620
119establishment of protein localization to Golgi (GO:0072600)2.40610748
120iron ion import (GO:0097286)2.39770781
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38961728
122adherens junction assembly (GO:0034333)2.38881952
123protein palmitoylation (GO:0018345)2.37935998
124behavioral response to ethanol (GO:0048149)2.37376898
125chondrocyte proliferation (GO:0035988)2.37184672
126pigment cell differentiation (GO:0050931)2.36908593
127ER overload response (GO:0006983)2.36729588
128membrane depolarization during action potential (GO:0086010)2.36679820
129glomerular visceral epithelial cell development (GO:0072015)2.36652472
130retina vasculature morphogenesis in camera-type eye (GO:0061299)2.36355200
131peptidyl-lysine trimethylation (GO:0018023)2.36313940
132membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36163656
133histone demethylation (GO:0016577)2.35610383
134cortical cytoskeleton organization (GO:0030865)2.35464843
135regulation of Rap GTPase activity (GO:0032317)2.35233727
136regulation of transforming growth factor beta2 production (GO:0032909)2.35208449
137cell migration in hindbrain (GO:0021535)2.34772926
138neuron cell-cell adhesion (GO:0007158)2.34152798
139negative regulation of neurotransmitter secretion (GO:0046929)2.33607925
140retrograde transport, vesicle recycling within Golgi (GO:0000301)2.33486938
141startle response (GO:0001964)2.33485153
142regulation of steroid hormone biosynthetic process (GO:0090030)2.32832115
143membrane raft organization (GO:0031579)2.32164599
144hippo signaling (GO:0035329)2.32161474
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.31603604
146positive regulation of cardiac muscle hypertrophy (GO:0010613)2.31276825
147positive regulation of muscle hypertrophy (GO:0014742)2.31276825
148microtubule polymerization or depolymerization (GO:0031109)2.30785858
149receptor recycling (GO:0001881)2.30324223
150positive regulation of insulin receptor signaling pathway (GO:0046628)2.29511386
151negative regulation of potassium ion transmembrane transport (GO:1901380)2.29467295
152macroautophagy (GO:0016236)2.28786770
153peptidyl-lysine dimethylation (GO:0018027)2.28577058
154dendrite morphogenesis (GO:0048813)2.28225552
155positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.28011016
156regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.28011016
157cell migration involved in sprouting angiogenesis (GO:0002042)2.27747843
158mesenchymal-epithelial cell signaling (GO:0060638)2.27566942
159glutamate secretion (GO:0014047)2.27306527
160phospholipid dephosphorylation (GO:0046839)2.27243002
161negative regulation of translation, ncRNA-mediated (GO:0040033)2.26171746
162regulation of translation, ncRNA-mediated (GO:0045974)2.26171746
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.26171746
164peptidyl-threonine modification (GO:0018210)2.26163884
165activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.25784425
166negative regulation of hormone biosynthetic process (GO:0032353)2.25404741
167negative regulation of hormone metabolic process (GO:0032351)2.25404741
168cytoplasmic mRNA processing body assembly (GO:0033962)2.25075024
169protein demethylation (GO:0006482)2.24823520
170protein dealkylation (GO:0008214)2.24823520
171regulation of DNA endoreduplication (GO:0032875)2.24571464
172dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.23743552
173endoplasmic reticulum unfolded protein response (GO:0030968)2.23245581
174Golgi to plasma membrane protein transport (GO:0043001)2.23219044
175regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.22284529
176phosphatidylinositol phosphorylation (GO:0046854)2.20903704
177ER-nucleus signaling pathway (GO:0006984)2.19820301
178peptidyl-proline hydroxylation (GO:0019511)2.19747466
179negative regulation of fatty acid transport (GO:2000192)2.18340391
180positive regulation of p38MAPK cascade (GO:1900745)2.18072131
181UDP-N-acetylglucosamine metabolic process (GO:0006047)2.18039120
182Golgi to plasma membrane transport (GO:0006893)2.17167870
183fatty acid homeostasis (GO:0055089)2.15967216
184substrate-dependent cell migration (GO:0006929)2.15405126
185positive regulation of fibroblast migration (GO:0010763)2.15248863
186regulation of Rac protein signal transduction (GO:0035020)2.14564473
187maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.14113837
188positive regulation of nuclease activity (GO:0032075)2.13940813
189regulation of nucleobase-containing compound transport (GO:0032239)2.13649303
190negative regulation of dendrite morphogenesis (GO:0050774)2.13297605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.97919452
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.84508421
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83693808
4GBX2_23144817_ChIP-Seq_PC3_Human3.59000998
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50772245
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.89896727
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.88843592
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.86293648
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.48068452
10DROSHA_22980978_ChIP-Seq_HELA_Human2.30050340
11EZH2_22144423_ChIP-Seq_EOC_Human2.26099408
12BRD4_25478319_ChIP-Seq_HGPS_Human2.25647729
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.24709691
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20296105
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16929969
16CLOCK_20551151_ChIP-Seq_293T_Human2.12890524
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07584842
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06120274
19RARB_27405468_Chip-Seq_BRAIN_Mouse1.97206809
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.88974580
21* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.88559531
22* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.88559531
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.85371172
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.83598276
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82141867
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82141867
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79958608
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79290864
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77783851
30CJUN_26792858_Chip-Seq_BT549_Human1.77569700
31STAT3_23295773_ChIP-Seq_U87_Human1.77248929
32REST_21632747_ChIP-Seq_MESCs_Mouse1.76958157
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74667397
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74325162
35SMAD4_21799915_ChIP-Seq_A2780_Human1.68407252
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66521730
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65945368
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65864662
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65589555
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62513847
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61365085
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60984375
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59170195
44* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57964984
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57697242
46AR_21909140_ChIP-Seq_LNCAP_Human1.55880950
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.55113617
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53992204
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52182265
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50111482
51TP53_18474530_ChIP-ChIP_U2OS_Human1.50084868
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.49698143
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48755829
54TCF4_23295773_ChIP-Seq_U87_Human1.48159201
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46144549
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46116379
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.46039941
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45943040
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45428866
60AR_21572438_ChIP-Seq_LNCaP_Human1.45062970
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.44699325
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44524126
63* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42554511
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41839045
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40066383
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39758840
67* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39093691
68* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37727270
69TP53_16413492_ChIP-PET_HCT116_Human1.37596522
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.37269795
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36791596
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34954265
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34415693
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34183382
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33650244
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33412176
77* NFE2_27457419_Chip-Seq_LIVER_Mouse1.32748217
78* NANOG_18555785_Chip-Seq_ESCs_Mouse1.31964200
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31049060
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30825218
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29842532
82TBL1_22424771_ChIP-Seq_293T_Human1.27731460
83ER_23166858_ChIP-Seq_MCF-7_Human1.27691369
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26963971
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26650889
86* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26455396
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.24012687
88TAF15_26573619_Chip-Seq_HEK293_Human1.23886503
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.23065836
90TP63_23658742_ChIP-Seq_EP156T_Human1.22772468
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22074843
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.21754856
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21033790
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21033790
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.20235574
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.19168931
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18586979
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.18151891
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.18151047
100AHR_22903824_ChIP-Seq_MCF-7_Human1.17060205
101* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16025277
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15756914
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13421181
104ZNF274_21170338_ChIP-Seq_K562_Hela1.13276841
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13201204
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12954909
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12866552
108* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12453936
109SOX2_20726797_ChIP-Seq_SW620_Human1.12166962
110* EZH2_27294783_Chip-Seq_NPCs_Mouse1.11763023
111AR_25329375_ChIP-Seq_VCAP_Human1.11523326
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.10837713
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10659014
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09804967
115FUS_26573619_Chip-Seq_HEK293_Human1.09641516
116TBX20_22080862_ChIP-Seq_HEART_Mouse1.09545529
117TBX20_22328084_ChIP-Seq_HEART_Mouse1.09545529
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.08212995
119* CMYC_18555785_Chip-Seq_ESCs_Mouse1.08168726
120* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08039635
121* E2F1_18555785_Chip-Seq_ESCs_Mouse1.05831043
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05823575
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05552086
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05264171
125P300_19829295_ChIP-Seq_ESCs_Human1.05187958
126AR_19668381_ChIP-Seq_PC3_Human1.05025442
127CDX2_22108803_ChIP-Seq_LS180_Human1.04666826
128EED_16625203_ChIP-ChIP_MESCs_Mouse1.04486558
129SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04102886
130* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03573505
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03363438
132* P53_22387025_ChIP-Seq_ESCs_Mouse1.03048314
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02920868
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02705066
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02266275
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00892593
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00685017
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00150379
139RUNX2_22187159_ChIP-Seq_PCA_Human0.99557492
140TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98357370
141* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98230563
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97998529
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97700512
144JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97622112
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97261077
146EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96695718
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96693614
148* P300_18555785_Chip-Seq_ESCs_Mouse0.96530076
149* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96258368
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95849790
151KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94809455
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94609277
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94583994
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94347348
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94347348
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93280125
157* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92808951
158* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92658739
159TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92078818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.68655101
2MP0000372_irregular_coat_pigmentation5.60506983
3MP0005171_absent_coat_pigmentation5.30401890
4MP0005275_abnormal_skin_tensile4.19382203
5MP0003705_abnormal_hypodermis_morpholog3.92661104
6MP0000569_abnormal_digit_pigmentation3.78514723
7MP0010352_gastrointestinal_tract_polyps3.62903480
8MP0003566_abnormal_cell_adhesion3.09082745
9MP0004859_abnormal_synaptic_plasticity3.05184804
10MP0004272_abnormal_basement_membrane2.96122308
11MP0004381_abnormal_hair_follicle2.92785092
12MP0002877_abnormal_melanocyte_morpholog2.72380910
13MP0005503_abnormal_tendon_morphology2.66959550
14MP0005408_hypopigmentation2.61390963
15MP0000015_abnormal_ear_pigmentation2.57449705
16MP0009046_muscle_twitch2.51798497
17MP0003941_abnormal_skin_development2.50250108
18MP0006054_spinal_hemorrhage2.36927192
19MP0004885_abnormal_endolymph2.31266411
20MP0001958_emphysema2.28409758
21MP0000371_diluted_coat_color2.26932098
22MP0003136_yellow_coat_color2.13758271
23MP0002060_abnormal_skin_morphology2.11325095
24MP0003091_abnormal_cell_migration2.09532021
25MP0002095_abnormal_skin_pigmentation2.07535709
26* MP0003635_abnormal_synaptic_transmissio1.97659636
27MP0005423_abnormal_somatic_nervous1.96422300
28MP0003787_abnormal_imprinting1.91370869
29MP0001486_abnormal_startle_reflex1.83378345
30MP0003880_abnormal_central_pattern1.81246312
31MP0001188_hyperpigmentation1.77124434
32MP0003279_aneurysm1.74320558
33MP0002102_abnormal_ear_morphology1.68728528
34MP0009745_abnormal_behavioral_response1.68421686
35MP0002064_seizures1.67346772
36MP0010678_abnormal_skin_adnexa1.66109905
37MP0005023_abnormal_wound_healing1.64128351
38MP0005377_hearing/vestibular/ear_phenot1.61584097
39MP0003878_abnormal_ear_physiology1.61584097
40MP0001986_abnormal_taste_sensitivity1.58075149
41MP0000383_abnormal_hair_follicle1.57348318
42MP0010307_abnormal_tumor_latency1.55999292
43MP0000751_myopathy1.55273129
44MP0003045_fibrosis1.55230434
45MP0010368_abnormal_lymphatic_system1.55048130
46MP0008260_abnormal_autophagy1.52843393
47MP0002896_abnormal_bone_mineralization1.52307682
48MP0004270_analgesia1.52088850
49MP0001324_abnormal_eye_pigmentation1.48384516
50MP0004084_abnormal_cardiac_muscle1.47575304
51MP0002272_abnormal_nervous_system1.44949947
52MP0005174_abnormal_tail_pigmentation1.41977883
53MP0004742_abnormal_vestibular_system1.41089858
54MP0002638_abnormal_pupillary_reflex1.40643443
55MP0002075_abnormal_coat/hair_pigmentati1.38884886
56MP0002063_abnormal_learning/memory/cond1.33878300
57MP0002067_abnormal_sensory_capabilities1.33500904
58MP0002572_abnormal_emotion/affect_behav1.32162674
59MP0005257_abnormal_intraocular_pressure1.29379550
60MP0005551_abnormal_eye_electrophysiolog1.28344969
61MP0005076_abnormal_cell_differentiation1.27846265
62MP0002295_abnormal_pulmonary_circulatio1.26476370
63MP0001440_abnormal_grooming_behavior1.25418358
64MP0004036_abnormal_muscle_relaxation1.24817850
65MP0002909_abnormal_adrenal_gland1.24162686
66MP0000013_abnormal_adipose_tissue1.23634662
67MP0001186_pigmentation_phenotype1.21560088
68MP0000733_abnormal_muscle_development1.20639134
69MP0002090_abnormal_vision1.20400205
70MP0000427_abnormal_hair_cycle1.19628471
71MP0008877_abnormal_DNA_methylation1.19423080
72MP0008569_lethality_at_weaning1.19134738
73MP0002822_catalepsy1.18986980
74MP0003283_abnormal_digestive_organ1.17462346
75MP0001661_extended_life_span1.16559239
76MP0005645_abnormal_hypothalamus_physiol1.16382906
77MP0000579_abnormal_nail_morphology1.15485881
78MP0000003_abnormal_adipose_tissue1.15444169
79MP0001299_abnormal_eye_distance/1.15297896
80MP0002108_abnormal_muscle_morphology1.15138490
81MP0000747_muscle_weakness1.14916486
82MP0001243_abnormal_dermal_layer1.14898169
83MP0003453_abnormal_keratinocyte_physiol1.14714966
84MP0006072_abnormal_retinal_apoptosis1.14007621
85MP0005623_abnormal_meninges_morphology1.12417761
86MP0000767_abnormal_smooth_muscle1.10549114
87MP0002229_neurodegeneration1.08351801
88MP0005409_darkened_coat_color1.07936609
89MP0000759_abnormal_skeletal_muscle1.07613105
90MP0002734_abnormal_mechanical_nocicepti1.07338833
91MP0001915_intracranial_hemorrhage1.06951498
92MP0001502_abnormal_circadian_rhythm1.06729440
93MP0000920_abnormal_myelination1.06507824
94MP0000955_abnormal_spinal_cord1.06432305
95MP0003172_abnormal_lysosome_physiology1.06296636
96MP0010234_abnormal_vibrissa_follicle1.05802226
97MP0002796_impaired_skin_barrier1.05732492
98MP0003632_abnormal_nervous_system1.04390282
99MP0000762_abnormal_tongue_morphology1.02092450
100MP0004087_abnormal_muscle_fiber1.00298489
101MP0000647_abnormal_sebaceous_gland0.99955745
102MP0000462_abnormal_digestive_system0.99924241
103MP0005621_abnormal_cell_physiology0.99479002
104MP0001501_abnormal_sleep_pattern0.98756207
105MP0004233_abnormal_muscle_weight0.98698432
106MP0008057_abnormal_DNA_replication0.97962011
107MP0008961_abnormal_basal_metabolism0.97534281
108MP0003191_abnormal_cellular_cholesterol0.97513285
109MP0003656_abnormal_erythrocyte_physiolo0.96844327
110MP0001216_abnormal_epidermal_layer0.96754670
111MP0003183_abnormal_peptide_metabolism0.96163253
112MP0002735_abnormal_chemical_nociception0.96028626
113MP0000428_abnormal_craniofacial_morphol0.95698405
114MP0003950_abnormal_plasma_membrane0.95301372
115MP0002184_abnormal_innervation0.94722593
116MP0001879_abnormal_lymphatic_vessel0.94571634
117MP0001542_abnormal_bone_strength0.93781558
118MP0004043_abnormal_pH_regulation0.92965084
119MP0004924_abnormal_behavior0.92196722
120MP0005386_behavior/neurological_phenoty0.92196722
121MP0001968_abnormal_touch/_nociception0.91374752
122MP0003868_abnormal_feces_composition0.89691512
123MP0005253_abnormal_eye_physiology0.87532639
124MP0003121_genomic_imprinting0.86835476
125MP0003329_amyloid_beta_deposits0.86711126
126MP0002269_muscular_atrophy0.86704562
127MP0009780_abnormal_chondrocyte_physiolo0.84743828
128MP0005075_abnormal_melanosome_morpholog0.84170777
129MP0000749_muscle_degeneration0.84111130
130MP0005058_abnormal_lysosome_morphology0.83492221
131MP0004811_abnormal_neuron_physiology0.83136196
132MP0009697_abnormal_copulation0.82866873
133MP0002882_abnormal_neuron_morphology0.82706808
134MP0003385_abnormal_body_wall0.82463245
135MP0001970_abnormal_pain_threshold0.81230830
136MP0004134_abnormal_chest_morphology0.80927660
137MP0002168_other_aberrant_phenotype0.80452834
138MP0002066_abnormal_motor_capabilities/c0.79306820
139MP0000377_abnormal_hair_follicle0.79086267
140MP0003300_gastrointestinal_ulcer0.78159282
141MP0001485_abnormal_pinna_reflex0.77259963
142MP0002971_abnormal_brown_adipose0.77202469
143MP0002557_abnormal_social/conspecific_i0.76757490
144MP0005501_abnormal_skin_physiology0.75150017
145MP0003115_abnormal_respiratory_system0.75146550
146MP0010771_integument_phenotype0.74981119
147MP0005508_abnormal_skeleton_morphology0.74576260
148MP0005384_cellular_phenotype0.74145980
149MP0010386_abnormal_urinary_bladder0.73731341
150MP0002009_preneoplasia0.72558374
151MP0004197_abnormal_fetal_growth/weight/0.71705294
152MP0002086_abnormal_extraembryonic_tissu0.70131056
153MP0004145_abnormal_muscle_electrophysio0.69411386
154MP0000778_abnormal_nervous_system0.69198744
155MP0001177_atelectasis0.68964925
156MP0003631_nervous_system_phenotype0.68734270
157MP0005165_increased_susceptibility_to0.68589554
158MP0003122_maternal_imprinting0.68557257
159MP0000432_abnormal_head_morphology0.67972321
160MP0005187_abnormal_penis_morphology0.66357093
161MP0005451_abnormal_body_composition0.65946748
162MP0002128_abnormal_blood_circulation0.64914064
163MP0009703_decreased_birth_body0.64139905
164MP0001849_ear_inflammation0.63597535
165MP0009384_cardiac_valve_regurgitation0.61547474
166MP0002084_abnormal_developmental_patter0.60595545
167MP0004185_abnormal_adipocyte_glucose0.59606453
168MP0002177_abnormal_outer_ear0.58935646
169MP0010630_abnormal_cardiac_muscle0.58893812
170MP0002925_abnormal_cardiovascular_devel0.58393243
171MP0001191_abnormal_skin_condition0.58294161
172MP0005375_adipose_tissue_phenotype0.57757289
173MP0002133_abnormal_respiratory_system0.56754261
174MP0005388_respiratory_system_phenotype0.56754261
175MP0003634_abnormal_glial_cell0.56632288

Predicted human phenotypes

RankGene SetZ-score
1Blue irides (HP:0000635)5.08587524
2Premature rupture of membranes (HP:0001788)5.06048633
3Protrusio acetabuli (HP:0003179)4.75368046
4Aplasia/Hypoplasia affecting the retina (HP:0008061)4.37710988
5Aplasia/Hypoplasia of the macula (HP:0008059)4.37672706
6Ocular albinism (HP:0001107)4.23148203
7Focal motor seizures (HP:0011153)4.15808988
8Atrophic scars (HP:0001075)4.15410017
9Hypoplasia of the fovea (HP:0007750)3.99695049
10Aplasia/Hypoplasia of the fovea (HP:0008060)3.99695049
11Vascular tortuosity (HP:0004948)3.82513261
12Aortic aneurysm (HP:0004942)3.72190983
13Aortic dissection (HP:0002647)3.70170661
14Iris hypopigmentation (HP:0007730)3.69689059
15Arterial tortuosity (HP:0005116)3.63031423
16Febrile seizures (HP:0002373)3.52109804
17Abnormality of the fovea (HP:0000493)3.37613321
18Focal seizures (HP:0007359)3.29386353
19Hypopigmentation of the fundus (HP:0007894)3.21734303
20Generalized hypopigmentation (HP:0007513)3.04617744
21Type 1 muscle fiber predominance (HP:0003803)3.01421650
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.93314947
23Overgrowth (HP:0001548)2.88956716
24Upper limb muscle weakness (HP:0003484)2.81666352
25Generalized hypopigmentation of hair (HP:0011358)2.78910456
26Bladder diverticulum (HP:0000015)2.78173430
27Atonic seizures (HP:0010819)2.75513661
28Congenital stationary night blindness (HP:0007642)2.70044963
29Wormian bones (HP:0002645)2.69874419
30Fragile skin (HP:0001030)2.68559870
31Osteolytic defects of the hand bones (HP:0009699)2.66813259
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.66813259
33Onion bulb formation (HP:0003383)2.60981051
34Congenital sensorineural hearing impairment (HP:0008527)2.60963272
35Macroorchidism (HP:0000053)2.60908291
36Truncal ataxia (HP:0002078)2.60284060
37Dilatation of the ascending aorta (HP:0005111)2.59998692
38Prostate neoplasm (HP:0100787)2.59499562
39Cerebral aneurysm (HP:0004944)2.57924199
40Spinal rigidity (HP:0003306)2.55445828
41Soft skin (HP:0000977)2.53570758
42Sensory axonal neuropathy (HP:0003390)2.50474931
43Visual hallucinations (HP:0002367)2.50449496
44Spondylolisthesis (HP:0003302)2.50074684
45Urinary bladder sphincter dysfunction (HP:0002839)2.44085391
46Distal lower limb amyotrophy (HP:0008944)2.43069501
47Spastic gait (HP:0002064)2.41277730
48Follicular hyperkeratosis (HP:0007502)2.41053552
49Gaze-evoked nystagmus (HP:0000640)2.40937536
50Impaired vibration sensation in the lower limbs (HP:0002166)2.40781133
51Impaired smooth pursuit (HP:0007772)2.39010279
52Lower limb amyotrophy (HP:0007210)2.36889094
53Bowel diverticulosis (HP:0005222)2.34971190
54Elfin facies (HP:0004428)2.34538814
55Insomnia (HP:0100785)2.34488080
56Ankle contracture (HP:0006466)2.34150167
57Abnormality of dentin (HP:0010299)2.33949773
58Volvulus (HP:0002580)2.32762903
59Right ventricular cardiomyopathy (HP:0011663)2.30696932
60Epileptic encephalopathy (HP:0200134)2.28036977
61Generalized tonic-clonic seizures (HP:0002069)2.27425225
62Slow saccadic eye movements (HP:0000514)2.26388001
63Natal tooth (HP:0000695)2.24631993
64Abnormal auditory evoked potentials (HP:0006958)2.22796500
65Mitral valve prolapse (HP:0001634)2.22378757
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22063201
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.22063201
68Cardiovascular calcification (HP:0011915)2.21825560
69Dysmetric saccades (HP:0000641)2.21684990
70Dialeptic seizures (HP:0011146)2.20689174
71Aneurysm (HP:0002617)2.19880089
72Subacute progressive viral hepatitis (HP:0006572)2.19634695
73Submucous cleft hard palate (HP:0000176)2.18565219
74Progressive cerebellar ataxia (HP:0002073)2.17175606
75Neonatal short-limb short stature (HP:0008921)2.16370549
76Absent frontal sinuses (HP:0002688)2.15271394
77Abnormality of the corticospinal tract (HP:0002492)2.15173249
78Overriding aorta (HP:0002623)2.14550422
79Asymmetry of the thorax (HP:0001555)2.14445075
80Nemaline bodies (HP:0003798)2.14233957
81Increased variability in muscle fiber diameter (HP:0003557)2.12711633
82Increased connective tissue (HP:0009025)2.12528542
83Advanced eruption of teeth (HP:0006288)2.11987280
84Hyperacusis (HP:0010780)2.11202133
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10528784
86Hypoglycemic coma (HP:0001325)2.10281577
87Hyperextensible skin (HP:0000974)2.09323179
88Tetraparesis (HP:0002273)2.08489296
89Open mouth (HP:0000194)2.08347118
90Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.07700178
91Absence seizures (HP:0002121)2.06045872
92Oligodactyly (hands) (HP:0001180)2.05025855
93Hypoglycemic seizures (HP:0002173)2.04925692
94Drooling (HP:0002307)2.04883552
95Excessive salivation (HP:0003781)2.04883552
96Supranuclear gaze palsy (HP:0000605)2.04691577
97Hypoplasia of the iris (HP:0007676)2.04005512
98Epileptiform EEG discharges (HP:0011182)2.03048583
99Ankyloglossia (HP:0010296)2.02798245
100Abnormality of ocular smooth pursuit (HP:0000617)2.02488740
101Genetic anticipation (HP:0003743)2.01386845
102EEG with generalized epileptiform discharges (HP:0011198)2.01247200
103Abnormality of nail color (HP:0100643)2.00035370
104Muscle fiber inclusion bodies (HP:0100299)1.99821429
105Neurofibrillary tangles (HP:0002185)1.99710352
106Decreased motor nerve conduction velocity (HP:0003431)1.97897837
107Cutaneous melanoma (HP:0012056)1.97062723
108Hyperkalemia (HP:0002153)1.96338852
109Symptomatic seizures (HP:0011145)1.96323153
110Ankle clonus (HP:0011448)1.96109306
111Dysmetria (HP:0001310)1.95204790
112Vertebral compression fractures (HP:0002953)1.95063329
113Entropion (HP:0000621)1.94660361
114Abnormality of saccadic eye movements (HP:0000570)1.94323694
115Abnormality of skeletal muscle fiber size (HP:0012084)1.94101639
116Genu recurvatum (HP:0002816)1.92037127
117Cervical subluxation (HP:0003308)1.91616165
118Enlarged penis (HP:0000040)1.90808844
119Mildly elevated creatine phosphokinase (HP:0008180)1.89100941
120Renovascular hypertension (HP:0100817)1.88525280
121Abnormal delivery (HP:0001787)1.88294094
122Insulin-resistant diabetes mellitus (HP:0000831)1.87800499
123Obsessive-compulsive behavior (HP:0000722)1.87617854
124Joint laxity (HP:0001388)1.87543562
125Hypsarrhythmia (HP:0002521)1.87507569
126Protruding tongue (HP:0010808)1.87270279
127Cubitus valgus (HP:0002967)1.86647683
128Relative macrocephaly (HP:0004482)1.86616004
129Spastic paraplegia (HP:0001258)1.86497132
130Exotropia (HP:0000577)1.86112546
131Urinary urgency (HP:0000012)1.85435503
132Upper limb amyotrophy (HP:0009129)1.84122117
133Distal upper limb amyotrophy (HP:0007149)1.84122117
134Mitral stenosis (HP:0001718)1.83862028
135Delayed closure of the anterior fontanelle (HP:0001476)1.83479969
136Peritonitis (HP:0002586)1.83463909
137Milia (HP:0001056)1.82664526
138Distal sensory impairment (HP:0002936)1.81607154
139Hyperglycemia (HP:0003074)1.79597700
140Subaortic stenosis (HP:0001682)1.79169340
141Abnormality of the left ventricular outflow tract (HP:0011103)1.79169340
142Papillary thyroid carcinoma (HP:0002895)1.78800360
143Bundle branch block (HP:0011710)1.77891610
144Abnormality of the acetabulum (HP:0003170)1.77507290
145Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76927253
146Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76693850
147Insidious onset (HP:0003587)1.75726720
148Termporal pattern (HP:0011008)1.75726720
149Abnormality of the fingertips (HP:0001211)1.75487888
150Cerebral inclusion bodies (HP:0100314)1.75385259
151Metabolic alkalosis (HP:0200114)1.75306528
152Hand muscle atrophy (HP:0009130)1.74587616
153Action tremor (HP:0002345)1.74117473
154Hyperinsulinemic hypoglycemia (HP:0000825)1.73298333
155Wide anterior fontanel (HP:0000260)1.71733640
156Pulmonic stenosis (HP:0001642)1.71311704
157Neoplasm of the heart (HP:0100544)1.71157865
158Vertebral arch anomaly (HP:0008438)1.71116312
159White forelock (HP:0002211)1.70699238
160Truncal obesity (HP:0001956)1.70602226
161Intention tremor (HP:0002080)1.69733159
162Abnormality of the ischium (HP:0003174)1.69703110
163Freckling (HP:0001480)1.68280838
164Postural instability (HP:0002172)1.67799131
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67750567
166Resting tremor (HP:0002322)1.66767683
167Ulnar bowing (HP:0003031)1.66260286
168Alopecia of scalp (HP:0002293)1.66106688
169Peripheral hypomyelination (HP:0007182)1.65615829
170Hammertoe (HP:0001765)1.65570122
171Paraplegia (HP:0010550)1.65487367
172Hyporeflexia of lower limbs (HP:0002600)1.65477135
173Breech presentation (HP:0001623)1.65405780
174Shallow orbits (HP:0000586)1.65351998
175Mild short stature (HP:0003502)1.65146533
176Dysdiadochokinesis (HP:0002075)1.64762030
177Impulsivity (HP:0100710)1.64634084
178Abnormality of oral frenula (HP:0000190)1.63845721
179Protruding ear (HP:0000411)1.63739219
180Abnormality of calcium-phosphate metabolism (HP:0100530)1.63718525
181Broad metatarsal (HP:0001783)1.63583520
182Heterotopia (HP:0002282)1.63090006
183Plantar hyperkeratosis (HP:0007556)1.62316788
184Onycholysis (HP:0001806)1.61561046
185Tibial bowing (HP:0002982)1.59818678
186Autoamputation (HP:0001218)1.58168966
187Hypoplastic ischia (HP:0003175)1.57850721
188Asymmetric septal hypertrophy (HP:0001670)1.57718801
189Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.57047720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.79017774
2PNCK3.07919309
3NTRK32.95356637
4LATS22.54416105
5NEK92.51134250
6AKT32.39537931
7MAP3K92.39316800
8TTN2.13258011
9LATS11.98998378
10MET1.96962208
11TRPM71.95798869
12MAP3K131.87711798
13CAMK1G1.84248178
14INSRR1.81293275
15FGFR31.79802678
16MARK31.74697243
17WNK11.73602108
18MAP3K41.73460685
19MYLK1.72919950
20SGK21.71973231
21SGK2231.67689118
22SGK4941.67689118
23FGFR21.65790661
24RIPK11.57032357
25BRD41.56351385
26JAK11.56279214
27ALK1.54933891
28SGK31.54606726
29DDR21.50784048
30STK391.47829530
31STK38L1.46304440
32ERBB31.43802579
33CAMK1D1.41980764
34NTRK11.40602038
35EPHA41.38794293
36STK241.34733344
37PAK61.24727388
38EIF2AK31.24594394
39NEK21.24383102
40PDGFRB1.24205256
41FGFR41.23879390
42MST41.22956862
43CAMKK21.22878740
44TNK21.21811200
45RET1.16199428
46PKN21.15976340
47MAP3K121.12600569
48EIF2AK11.12340443
49TSSK61.11952290
50OXSR11.10085180
51EEF2K1.10031532
52SGK11.07139538
53PAK21.05642473
54FRK1.05562725
55DMPK1.04943363
56SCYL21.04836040
57CSNK1A1L1.01710783
58CAMKK11.01183988
59SIK21.00936411
60TAOK31.00178087
61MARK20.99724217
62FER0.96162401
63STK110.95769807
64STK380.94996821
65MAPKAPK50.91473213
66HIPK20.91107292
67BRSK20.90280494
68PDK40.90073299
69PDK30.90073299
70PLK20.88933618
71PRKCH0.88693569
72CLK10.88608893
73WNK40.88037027
74PIK3CG0.87963179
75TRIB30.87506945
76ROCK20.86235805
77MAP3K140.86040841
78EPHA30.85827058
79NTRK20.84922157
80MOS0.84631909
81CDK120.84514866
82TGFBR20.84439821
83ERBB40.84181770
84ICK0.84029538
85LMTK20.83891571
86MAP3K20.82719836
87PDK10.82153527
88PHKG20.81745575
89PHKG10.81745575
90BMX0.81280848
91SIK10.81097796
92STK30.80856645
93TNIK0.79101558
94MAP3K70.78221960
95CDK50.77508242
96RAF10.76806809
97CSNK1G20.76792757
98WNK30.76218673
99IRAK30.75397267
100NEK60.74864820
101FES0.73518446
102PASK0.72854611
103OBSCN0.71778274
104MAP2K10.69895610
105PDPK10.67860664
106MAPK100.67842557
107GRK10.66374157
108MELK0.65607504
109ZAK0.65245416
110PRKAA10.64904647
111WEE10.64713945
112PAK30.63151497
113PBK0.62135863
114KSR10.61849158
115EPHB10.61663709
116PKN10.61640671
117TTK0.60820075
118CDC42BPA0.60454350
119PTK20.60040779
120PDGFRA0.59493097
121CSNK1G10.58263039
122PRKAA20.58022092
123CAMK2B0.57786079
124UHMK10.57450097
125EPHB20.56606781
126NEK10.56188852
127KSR20.56045642
128BMPR20.54586257
129YES10.54479082
130MAP2K40.53217270
131PRKD20.53064397
132ROCK10.52170419
133TYRO30.51948492
134DAPK20.51817451
135MKNK20.50547906
136MAP2K70.49651115
137BRAF0.48544106
138CSNK1E0.48089725
139ARAF0.47016317
140CSNK1G30.46880495
141PAK40.46792052
142MARK10.46549798
143CSNK1D0.45401255
144MAPK80.44205207
145MTOR0.43461806
146NUAK10.42932811
147RPS6KB10.42636532
148RPS6KA30.42557713
149PTK2B0.42062605
150CDK60.41540542
151TGFBR10.40397661
152MAP3K10.39933506
153MAPK70.39674206
154MAP3K60.36490142

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.33195377
2Vitamin B6 metabolism_Homo sapiens_hsa007502.18431380
3Phosphatidylinositol signaling system_Homo sapiens_hsa040702.12114561
4ECM-receptor interaction_Homo sapiens_hsa045122.11738927
5Adherens junction_Homo sapiens_hsa045201.98906774
6Focal adhesion_Homo sapiens_hsa045101.96805866
7Insulin secretion_Homo sapiens_hsa049111.89390175
8Synaptic vesicle cycle_Homo sapiens_hsa047211.89322733
9Glutamatergic synapse_Homo sapiens_hsa047241.83629630
10Morphine addiction_Homo sapiens_hsa050321.83402204
11Type II diabetes mellitus_Homo sapiens_hsa049301.80657480
12Circadian entrainment_Homo sapiens_hsa047131.77711471
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76543737
14GABAergic synapse_Homo sapiens_hsa047271.75782041
15Inositol phosphate metabolism_Homo sapiens_hsa005621.75662437
16Proteoglycans in cancer_Homo sapiens_hsa052051.74710773
17Long-term potentiation_Homo sapiens_hsa047201.73895804
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69949877
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68142067
20Taste transduction_Homo sapiens_hsa047421.66283731
21Amphetamine addiction_Homo sapiens_hsa050311.58286023
22Salivary secretion_Homo sapiens_hsa049701.57256744
23Long-term depression_Homo sapiens_hsa047301.51754153
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50138235
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49492172
26Dorso-ventral axis formation_Homo sapiens_hsa043201.47398053
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44437877
28Amoebiasis_Homo sapiens_hsa051461.44141281
29Olfactory transduction_Homo sapiens_hsa047401.43202594
30Dopaminergic synapse_Homo sapiens_hsa047281.41179850
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39660487
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38858538
33Cholinergic synapse_Homo sapiens_hsa047251.38729451
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36235632
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32342498
36Gastric acid secretion_Homo sapiens_hsa049711.30107753
37mTOR signaling pathway_Homo sapiens_hsa041501.29505949
38Small cell lung cancer_Homo sapiens_hsa052221.26613900
39Renin secretion_Homo sapiens_hsa049241.25319691
40MicroRNAs in cancer_Homo sapiens_hsa052061.24267369
41Cocaine addiction_Homo sapiens_hsa050301.24188670
42Estrogen signaling pathway_Homo sapiens_hsa049151.19659586
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19393110
44Pancreatic secretion_Homo sapiens_hsa049721.17719503
45Phototransduction_Homo sapiens_hsa047441.15342712
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.15103788
47Serotonergic synapse_Homo sapiens_hsa047261.15046611
48Circadian rhythm_Homo sapiens_hsa047101.14324439
49Renal cell carcinoma_Homo sapiens_hsa052111.13118671
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.12941992
51Oxytocin signaling pathway_Homo sapiens_hsa049211.12062647
52GnRH signaling pathway_Homo sapiens_hsa049121.10761911
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09566644
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08153119
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07570816
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07324400
57Collecting duct acid secretion_Homo sapiens_hsa049661.05855382
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04292798
59Choline metabolism in cancer_Homo sapiens_hsa052311.02749206
60Lysine degradation_Homo sapiens_hsa003101.02540301
61cAMP signaling pathway_Homo sapiens_hsa040241.01478952
62Alcoholism_Homo sapiens_hsa050341.00993972
63Melanogenesis_Homo sapiens_hsa049160.98869313
64Protein digestion and absorption_Homo sapiens_hsa049740.97813430
65Non-homologous end-joining_Homo sapiens_hsa034500.97484780
66Calcium signaling pathway_Homo sapiens_hsa040200.97354654
67Tight junction_Homo sapiens_hsa045300.97214676
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96983932
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96516628
70Regulation of autophagy_Homo sapiens_hsa041400.96476915
71Ovarian steroidogenesis_Homo sapiens_hsa049130.96203576
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.95514605
73ErbB signaling pathway_Homo sapiens_hsa040120.92732214
74Sphingolipid metabolism_Homo sapiens_hsa006000.92441736
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.92326617
76Thyroid cancer_Homo sapiens_hsa052160.92274347
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87572061
78Tyrosine metabolism_Homo sapiens_hsa003500.86905918
79Pancreatic cancer_Homo sapiens_hsa052120.85833520
80Glioma_Homo sapiens_hsa052140.85591846
81ABC transporters_Homo sapiens_hsa020100.84615356
82TGF-beta signaling pathway_Homo sapiens_hsa043500.83374280
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83359889
84Melanoma_Homo sapiens_hsa052180.82896049
85Oocyte meiosis_Homo sapiens_hsa041140.82584633
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82330148
87Hippo signaling pathway_Homo sapiens_hsa043900.82136007
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79685964
89MAPK signaling pathway_Homo sapiens_hsa040100.78341425
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78250132
91Thyroid hormone synthesis_Homo sapiens_hsa049180.77443871
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76558115
93Bladder cancer_Homo sapiens_hsa052190.75539516
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74470659
95Glucagon signaling pathway_Homo sapiens_hsa049220.72333091
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72233013
97Non-small cell lung cancer_Homo sapiens_hsa052230.71928415
98Fatty acid biosynthesis_Homo sapiens_hsa000610.71914035
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69426710
100VEGF signaling pathway_Homo sapiens_hsa043700.68571613
101Endocytosis_Homo sapiens_hsa041440.67865345
102Ether lipid metabolism_Homo sapiens_hsa005650.67628841
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66978670
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66475935
105Platelet activation_Homo sapiens_hsa046110.65863326
106Gap junction_Homo sapiens_hsa045400.65563061
107Vibrio cholerae infection_Homo sapiens_hsa051100.65366396
108Rap1 signaling pathway_Homo sapiens_hsa040150.64742388
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.64459479
110Pathways in cancer_Homo sapiens_hsa052000.64441814
111Insulin signaling pathway_Homo sapiens_hsa049100.64385895
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64288000
113Other glycan degradation_Homo sapiens_hsa005110.63809500
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63336386
115FoxO signaling pathway_Homo sapiens_hsa040680.63117894
116AMPK signaling pathway_Homo sapiens_hsa041520.62852828
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61909530
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61167572
119N-Glycan biosynthesis_Homo sapiens_hsa005100.60679344
120HIF-1 signaling pathway_Homo sapiens_hsa040660.59163227
121Prion diseases_Homo sapiens_hsa050200.58748241
122Lysosome_Homo sapiens_hsa041420.58354041
123Ras signaling pathway_Homo sapiens_hsa040140.58077705
124Wnt signaling pathway_Homo sapiens_hsa043100.57955297
125Chronic myeloid leukemia_Homo sapiens_hsa052200.57536548
126Axon guidance_Homo sapiens_hsa043600.57151460
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.54969989
128Dilated cardiomyopathy_Homo sapiens_hsa054140.53293252
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.53216509
130Colorectal cancer_Homo sapiens_hsa052100.52796344
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.52625039
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.52462027
133Prolactin signaling pathway_Homo sapiens_hsa049170.52125162
134Hedgehog signaling pathway_Homo sapiens_hsa043400.52118235
135Prostate cancer_Homo sapiens_hsa052150.50996430
136T cell receptor signaling pathway_Homo sapiens_hsa046600.50191071
137Insulin resistance_Homo sapiens_hsa049310.49490300
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48743042
139Endometrial cancer_Homo sapiens_hsa052130.45466021
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44279812

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »