RAB3IL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.11388852
2fusion of sperm to egg plasma membrane (GO:0007342)6.96931458
3cell wall macromolecule catabolic process (GO:0016998)6.47467006
4cell wall macromolecule metabolic process (GO:0044036)6.47467006
5sperm-egg recognition (GO:0035036)6.41312202
6acrosome reaction (GO:0007340)6.15645092
7binding of sperm to zona pellucida (GO:0007339)6.07331540
8cell-cell recognition (GO:0009988)5.88396744
9multicellular organism reproduction (GO:0032504)5.70725169
10acrosome assembly (GO:0001675)5.29712275
11spermatid development (GO:0007286)5.25126177
12plasma membrane fusion (GO:0045026)5.19058849
13reproduction (GO:0000003)5.14602271
14barbed-end actin filament capping (GO:0051016)5.05635724
15motile cilium assembly (GO:0044458)5.05018289
16negative regulation of erythrocyte differentiation (GO:0045647)4.92797574
17axonemal dynein complex assembly (GO:0070286)4.87997285
18synaptonemal complex assembly (GO:0007130)4.63827101
19adhesion of symbiont to host cell (GO:0044650)4.59429285
20virion attachment to host cell (GO:0019062)4.59429285
21microglial cell activation (GO:0001774)4.57377604
22microtubule depolymerization (GO:0007019)4.54850519
23regulation of interferon-beta biosynthetic process (GO:0045357)4.53745385
24negative regulation of inclusion body assembly (GO:0090084)4.53637859
25synaptonemal complex organization (GO:0070193)4.48213718
26adhesion of symbiont to host (GO:0044406)4.45728897
27piRNA metabolic process (GO:0034587)4.35223700
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27655937
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.27655937
30modulation by symbiont of host immune response (GO:0052553)4.27655937
31positive regulation by symbiont of host defense response (GO:0052509)4.27655937
32modulation by symbiont of host defense response (GO:0052031)4.27655937
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27655937
34protoporphyrinogen IX metabolic process (GO:0046501)4.25350914
35epithelial cilium movement (GO:0003351)4.23219593
36regulation of early endosome to late endosome transport (GO:2000641)4.19425041
37chromosome condensation (GO:0030261)4.18777524
38regulation of cilium movement (GO:0003352)4.13661326
39oxygen transport (GO:0015671)4.04630973
40regulation of inclusion body assembly (GO:0090083)4.01972795
41gas transport (GO:0015669)3.96931636
42protoporphyrinogen IX biosynthetic process (GO:0006782)3.94019958
43regulation of response to osmotic stress (GO:0047484)3.92273634
44cell migration involved in heart development (GO:0060973)3.88310054
45hemoglobin metabolic process (GO:0020027)3.87980901
46DNA packaging (GO:0006323)3.85941198
47cilium or flagellum-dependent cell motility (GO:0001539)3.85672764
48response to thyroid hormone (GO:0097066)3.78848814
49tooth mineralization (GO:0034505)3.78839649
50amino sugar catabolic process (GO:0046348)3.76348926
51spermatogenesis (GO:0007283)3.74659840
52single fertilization (GO:0007338)3.74367789
53male gamete generation (GO:0048232)3.73889845
54male meiosis (GO:0007140)3.69466992
55protein localization to endosome (GO:0036010)3.60430727
56protein heterotrimerization (GO:0070208)3.60099932
57extracellular fibril organization (GO:0043206)3.60055548
58organic cation transport (GO:0015695)3.59838300
59low-density lipoprotein particle clearance (GO:0034383)3.56808371
60apoptotic cell clearance (GO:0043277)3.56484807
61macrophage activation involved in immune response (GO:0002281)3.54713456
62positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.51908312
63gamete generation (GO:0007276)3.48573379
64fibril organization (GO:0097435)3.41190059
65negative regulation of granulocyte differentiation (GO:0030853)3.39711510
66positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.38092503
67male meiosis I (GO:0007141)3.37796901
68meiosis I (GO:0007127)3.36345482
69protein localization to chromosome, centromeric region (GO:0071459)3.33089845
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33064917
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32669374
72mannose metabolic process (GO:0006013)3.31737245
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.27238344
74fertilization (GO:0009566)3.26644229
75interferon-gamma secretion (GO:0072643)3.24795800
76decidualization (GO:0046697)3.23561578
77immunoglobulin mediated immune response (GO:0016064)3.21767646
78erythrocyte development (GO:0048821)3.20726793
79sexual reproduction (GO:0019953)3.18172128
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17555854
81positive regulation of receptor recycling (GO:0001921)3.17417826
82seminiferous tubule development (GO:0072520)3.15373651
83stress fiber assembly (GO:0043149)3.12689855
84regulation of spindle checkpoint (GO:0090231)3.12347343
85regulation of mononuclear cell migration (GO:0071675)3.10358075
86negative regulation of focal adhesion assembly (GO:0051895)3.10251376
87negative regulation of cell junction assembly (GO:1901889)3.10251376
88negative regulation of adherens junction organization (GO:1903392)3.10251376
89cellular response to arsenic-containing substance (GO:0071243)3.08133851
90N-acetylneuraminate metabolic process (GO:0006054)3.05413803
91cellular process involved in reproduction in multicellular organism (GO:0022412)3.03802419
92porphyrin-containing compound biosynthetic process (GO:0006779)3.02616351
93collagen metabolic process (GO:0032963)3.01644155
94cilium movement (GO:0003341)3.01099079
95polyamine biosynthetic process (GO:0006596)3.00146102
96meiotic nuclear division (GO:0007126)2.98092123
97germ cell development (GO:0007281)2.98001043
98extracellular matrix assembly (GO:0085029)2.96930966
99adenosine receptor signaling pathway (GO:0001973)2.96095815
100cytoskeletal anchoring at plasma membrane (GO:0007016)2.96050287
101chromosome organization involved in meiosis (GO:0070192)2.96004741
102heme biosynthetic process (GO:0006783)2.95443369
103collagen catabolic process (GO:0030574)2.95026788
104basement membrane organization (GO:0071711)2.92008619
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91491222
106positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.91126620
107monoubiquitinated protein deubiquitination (GO:0035520)2.90008894
108modulation by symbiont of host cellular process (GO:0044068)2.89948858
109macrophage activation (GO:0042116)2.88878997
110skin morphogenesis (GO:0043589)2.88134463
111positive regulation of chemokine secretion (GO:0090197)2.85163575
112regulation of cholesterol storage (GO:0010885)2.84949679
113response to methylmercury (GO:0051597)2.84655094
114embryo implantation (GO:0007566)2.83756278
115folic acid transport (GO:0015884)2.80223629
116positive regulation of interferon-alpha production (GO:0032727)2.80181638
117positive regulation of extracellular matrix organization (GO:1903055)2.79377797
118modulation by virus of host process (GO:0019054)2.78722693
119multicellular organismal macromolecule metabolic process (GO:0044259)2.76888593
120collagen fibril organization (GO:0030199)2.75884619
121keratan sulfate catabolic process (GO:0042340)2.75439131
122UV protection (GO:0009650)2.75024317
123protein targeting to plasma membrane (GO:0072661)2.74980822
124response to acidic pH (GO:0010447)2.73641513
125regulation of membrane protein ectodomain proteolysis (GO:0051043)2.73606040
126negative regulation of protein localization to plasma membrane (GO:1903077)2.73418463
127actin filament capping (GO:0051693)2.71836737
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71406570
129venous blood vessel morphogenesis (GO:0048845)2.71006301
130blastocyst development (GO:0001824)2.70915973
131glycosphingolipid catabolic process (GO:0046479)2.69431068
132multicellular organismal catabolic process (GO:0044243)2.68835984
133meiotic cell cycle (GO:0051321)2.68280959
134regulation of integrin-mediated signaling pathway (GO:2001044)2.68024981
135multicellular organismal reproductive process (GO:0048609)2.67929325
136oligosaccharide catabolic process (GO:0009313)2.67789722
137sperm capacitation (GO:0048240)2.66883125
138pinocytosis (GO:0006907)2.66657849
139protein retention in ER lumen (GO:0006621)2.65569539
140mitotic metaphase plate congression (GO:0007080)2.64513826
141cortical actin cytoskeleton organization (GO:0030866)2.64214900
142cellular response to thyroid hormone stimulus (GO:0097067)2.62496452
143positive regulation of cholesterol efflux (GO:0010875)2.61663628
144DNA replication-dependent nucleosome assembly (GO:0006335)2.60649937
145DNA replication-dependent nucleosome organization (GO:0034723)2.60649937
146response to arsenic-containing substance (GO:0046685)2.60577684
147hyaluronan catabolic process (GO:0030214)2.60270876
148regulation of interferon-alpha production (GO:0032647)2.58846416
149natural killer cell mediated cytotoxicity (GO:0042267)2.58750549
150natural killer cell mediated immunity (GO:0002228)2.58750549
151regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.58024600
152erythrocyte maturation (GO:0043249)2.57311435
153regulation of macrophage chemotaxis (GO:0010758)2.56475380
154endothelial cell chemotaxis (GO:0035767)2.56210783
155chondroitin sulfate catabolic process (GO:0030207)2.56121670
156endodermal cell differentiation (GO:0035987)2.55955157
157regulation of extracellular matrix disassembly (GO:0010715)2.55522592
158multicellular organismal metabolic process (GO:0044236)2.55452058
159tetrapyrrole biosynthetic process (GO:0033014)2.55219969
160glial cell migration (GO:0008347)2.55045290
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54575141
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54383538
163heme metabolic process (GO:0042168)2.54179491
164regulation of spindle organization (GO:0090224)2.53717292
165folic acid metabolic process (GO:0046655)2.53077903
166DNA methylation involved in gamete generation (GO:0043046)2.51632750
167positive regulation of chromosome segregation (GO:0051984)2.51367903
168regulation of chromosome segregation (GO:0051983)2.50095264
169COPI coating of Golgi vesicle (GO:0048205)2.49749804
170Golgi transport vesicle coating (GO:0048200)2.49749804
171porphyrin-containing compound metabolic process (GO:0006778)2.49695988
172extracellular matrix disassembly (GO:0022617)2.47778213
173vascular endothelial growth factor signaling pathway (GO:0038084)2.46434443
174regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.45500606
175iron ion import (GO:0097286)2.45148289
176vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.44675906
177ceramide catabolic process (GO:0046514)2.43837952
178glycolipid catabolic process (GO:0019377)2.42729378
179negative regulation of interleukin-6 production (GO:0032715)2.41374847
180cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.39975892
181positive regulation of triglyceride lipase activity (GO:0061365)2.39871206
182positive regulation of lipoprotein lipase activity (GO:0051006)2.39871206
183negative regulation of smooth muscle cell migration (GO:0014912)2.39858501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.64117270
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.02047904
3E2F7_22180533_ChIP-Seq_HELA_Human3.55484628
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.54137115
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.37400479
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.02934447
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.95911724
8* LXR_22292898_ChIP-Seq_THP-1_Human2.88241921
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.63836691
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38847676
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34747995
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23425859
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.22067957
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.20614679
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13056919
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01664048
17PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.98973458
18RACK7_27058665_Chip-Seq_MCF-7_Human1.98888705
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98012089
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96503395
21KDM2B_26808549_Chip-Seq_K562_Human1.94778097
22KDM2B_26808549_Chip-Seq_DND41_Human1.91520609
23CLOCK_20551151_ChIP-Seq_293T_Human1.88825556
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.86229768
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78134257
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77560021
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77347300
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71466963
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70356253
30SCL_19346495_ChIP-Seq_HPC-7_Human1.70131845
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.68985932
32GATA1_22025678_ChIP-Seq_K562_Human1.67338124
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66846813
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66757699
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64141954
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63962479
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62886407
38CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62410342
39NCOR1_26117541_ChIP-Seq_K562_Human1.61024566
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.58033686
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57243856
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57124897
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.54916787
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54457074
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53061802
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.52951728
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52642344
48SPI1_23547873_ChIP-Seq_NB4_Human1.51775930
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51428335
50* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50122186
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48161510
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48114480
53AR_21909140_ChIP-Seq_LNCAP_Human1.46164434
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45876022
55* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44677479
56KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.44461352
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.41127744
58P68_20966046_ChIP-Seq_HELA_Human1.39769111
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39375257
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39082912
61* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38624094
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37216482
63* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37085284
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36852970
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.36096854
66* GATA2_19941826_ChIP-Seq_K562_Human1.35613134
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34368529
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.33840358
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33049981
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.32007052
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31940851
72* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31460672
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30934257
74VDR_21846776_ChIP-Seq_THP-1_Human1.29842096
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29028652
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28795024
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28752375
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28356514
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28171994
80ZNF263_19887448_ChIP-Seq_K562_Human1.27299698
81* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24812586
82FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24783881
83SMC4_20622854_ChIP-Seq_HELA_Human1.24207475
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23960822
85ATF3_27146783_Chip-Seq_COLON_Human1.23082530
86* GATA1_19941826_ChIP-Seq_K562_Human1.21805511
87TP53_22127205_ChIP-Seq_IMR90_Human1.21303480
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.21150081
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.21002707
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.20464982
91BCOR_27268052_Chip-Seq_Bcells_Human1.20251165
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19986341
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19938037
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19890918
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19589097
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19238494
97* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19234494
98SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18884351
99* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17630609
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17531371
101CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17402684
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17239175
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17218079
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16577935
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15875053
106GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15724045
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15186852
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14821679
109BCL6_27268052_Chip-Seq_Bcells_Human1.14732101
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14329307
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14085728
112* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14071047
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13807517
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13638603
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13072844
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10606607
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10210463
118* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10164854
119GATA3_21867929_ChIP-Seq_CD8_Mouse1.09199870
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09010576
121* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08843120
122CREB1_26743006_Chip-Seq_LNCaP_Human1.08321970
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.07986248
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07703927
125TCF7_22412390_ChIP-Seq_EML_Mouse1.06976532
126* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06819860
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.05980623
128SPI1_20517297_ChIP-Seq_HL60_Human1.05844959
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05566917
130* TBX20_22328084_ChIP-Seq_HEART_Mouse1.03643777
131* TBX20_22080862_ChIP-Seq_HEART_Mouse1.03643777
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03541677
133* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03455449
134FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03345640
135SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03181102
136EGR1_19374776_ChIP-ChIP_THP-1_Human1.02913534
137CTCF_26484167_Chip-Seq_Bcells_Mouse1.02374995
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01637376
139MYC_22102868_ChIP-Seq_BL_Human1.01584141
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00542387
141RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00519493
142* SPI1_23127762_ChIP-Seq_K562_Human1.00424422
143KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99921713
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.99894947
145PHF8_20622854_ChIP-Seq_HELA_Human0.99737843
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99715756
147VDR_24763502_ChIP-Seq_THP-1_Human0.99345634
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98107793
149TFEB_21752829_ChIP-Seq_HELA_Human0.96168270
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95585304
151PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95373651
152* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93826753
153STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93689069
154* ELK3_25401928_ChIP-Seq_HUVEC_Human0.92831527
155RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92510353
156YY1_22570637_ChIP-Seq_MALME-3M_Human0.91411355
157SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91127538
158VDR_23849224_ChIP-Seq_CD4+_Human0.90161926
159MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90012795
160* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89448733
161MYC_18555785_ChIP-Seq_MESCs_Mouse0.88584073
162MYB_26560356_Chip-Seq_TH1_Human0.88495274
163TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88164088
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88077683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.85798130
2MP0005058_abnormal_lysosome_morphology3.85867810
3MP0005503_abnormal_tendon_morphology3.59622175
4MP0003656_abnormal_erythrocyte_physiolo3.43853672
5MP0009840_abnormal_foam_cell3.21720240
6MP0005275_abnormal_skin_tensile2.85407548
7MP0003191_abnormal_cellular_cholesterol2.60131014
8MP0006082_CNS_inflammation2.57409582
9MP0003693_abnormal_embryo_hatching2.56404532
10MP0001929_abnormal_gametogenesis2.55620747
11MP0003111_abnormal_nucleus_morphology2.50565470
12MP0005670_abnormal_white_adipose2.48547473
13MP0004147_increased_porphyrin_level2.47384174
14MP0003698_abnormal_male_reproductive2.33131995
15MP0003172_abnormal_lysosome_physiology2.22875828
16MP0005397_hematopoietic_system_phenotyp2.09772112
17MP0001545_abnormal_hematopoietic_system2.09772112
18MP0001958_emphysema2.03365763
19MP0010307_abnormal_tumor_latency2.01876417
20MP0001835_abnormal_antigen_presentation1.99144398
21MP0008260_abnormal_autophagy1.98370356
22MP0009278_abnormal_bone_marrow1.88516514
23MP0008438_abnormal_cutaneous_collagen1.83137436
24MP0004272_abnormal_basement_membrane1.81498191
25MP0010094_abnormal_chromosome_stability1.80248654
26MP0003303_peritoneal_inflammation1.72502663
27MP0005464_abnormal_platelet_physiology1.71933210
28MP0003077_abnormal_cell_cycle1.67523936
29MP0002877_abnormal_melanocyte_morpholog1.67456359
30MP0002419_abnormal_innate_immunity1.66061022
31MP0000751_myopathy1.64652717
32MP0008877_abnormal_DNA_methylation1.57677202
33MP0002210_abnormal_sex_determination1.57380084
34MP0003436_decreased_susceptibility_to1.54759136
35MP0005083_abnormal_biliary_tract1.54364801
36MP0003329_amyloid_beta_deposits1.54186626
37MP0001849_ear_inflammation1.54052455
38MP0004858_abnormal_nervous_system1.52324919
39MP0002161_abnormal_fertility/fecundity1.51888208
40MP0002396_abnormal_hematopoietic_system1.50382041
41MP0005076_abnormal_cell_differentiation1.44133465
42MP0000465_gastrointestinal_hemorrhage1.43363922
43MP0008007_abnormal_cellular_replicative1.42736370
44MP0004510_myositis1.40631326
45MP0000747_muscle_weakness1.39444378
46MP0001145_abnormal_male_reproductive1.38676561
47MP0002653_abnormal_ependyma_morphology1.37833400
48MP0005508_abnormal_skeleton_morphology1.37428458
49MP0009333_abnormal_splenocyte_physiolog1.37331143
50MP0002295_abnormal_pulmonary_circulatio1.30434229
51MP0008058_abnormal_DNA_repair1.29201333
52MP0002060_abnormal_skin_morphology1.28106477
53MP0003453_abnormal_keratinocyte_physiol1.27568127
54MP0004957_abnormal_blastocyst_morpholog1.26900710
55MP0004808_abnormal_hematopoietic_stem1.26006507
56MP0000343_altered_response_to1.25358628
57MP0002452_abnormal_antigen_presenting1.23549344
58MP0000767_abnormal_smooth_muscle1.23309872
59MP0000689_abnormal_spleen_morphology1.22317262
60MP0003718_maternal_effect1.21697585
61MP0003186_abnormal_redox_activity1.21259098
62MP0003091_abnormal_cell_migration1.18786045
63MP0005671_abnormal_response_to1.17582841
64MP0003705_abnormal_hypodermis_morpholog1.17537331
65MP0001542_abnormal_bone_strength1.15270190
66MP0000653_abnormal_sex_gland1.14918396
67MP0000749_muscle_degeneration1.14712589
68MP0001533_abnormal_skeleton_physiology1.14211022
69MP0005000_abnormal_immune_tolerance1.13829780
70MP0009384_cardiac_valve_regurgitation1.13681421
71MP0002108_abnormal_muscle_morphology1.10901276
72MP0002723_abnormal_immune_serum1.08146482
73MP0005595_abnormal_vascular_smooth1.07310800
74MP0002405_respiratory_system_inflammati1.05908763
75MP0005025_abnormal_response_to1.05837777
76MP0008469_abnormal_protein_level1.03549213
77MP0002896_abnormal_bone_mineralization1.03089447
78MP0002722_abnormal_immune_system1.02504470
79MP0001243_abnormal_dermal_layer1.01920633
80MP0002398_abnormal_bone_marrow1.00988977
81MP0003634_abnormal_glial_cell1.00594728
82MP0004233_abnormal_muscle_weight0.98122035
83MP0001915_intracranial_hemorrhage0.97432049
84MP0002254_reproductive_system_inflammat0.97165446
85MP0003795_abnormal_bone_structure0.97126094
86MP0003448_altered_tumor_morphology0.97035935
87MP0003724_increased_susceptibility_to0.96360628
88MP0000759_abnormal_skeletal_muscle0.96064998
89MP0001819_abnormal_immune_cell0.95317624
90MP0002429_abnormal_blood_cell0.94354300
91MP0005257_abnormal_intraocular_pressure0.93861383
92MP0005375_adipose_tissue_phenotype0.93857351
93MP0002933_joint_inflammation0.93706721
94MP0003828_pulmonary_edema0.93623682
95MP0001800_abnormal_humoral_immune0.93215177
96MP0002420_abnormal_adaptive_immunity0.93153933
97MP0002148_abnormal_hypersensitivity_rea0.92917723
98MP0003690_abnormal_glial_cell0.91682660
99MP0006054_spinal_hemorrhage0.87281655
100MP0001851_eye_inflammation0.87241243
101MP0000604_amyloidosis0.86380968
102MP0000681_abnormal_thyroid_gland0.86038902
103MP0001730_embryonic_growth_arrest0.85686787
104MP0004185_abnormal_adipocyte_glucose0.85060730
105MP0005167_abnormal_blood-brain_barrier0.84421586
106MP0000313_abnormal_cell_death0.84213141
107MP0003279_aneurysm0.83861972
108MP0000490_abnormal_crypts_of0.83693735
109MP0000750_abnormal_muscle_regeneration0.83561533
110MP0000685_abnormal_immune_system0.82262192
111MP0000716_abnormal_immune_system0.81876682
112MP0005310_abnormal_salivary_gland0.81464035
113MP0000350_abnormal_cell_proliferation0.80405906
114MP0001845_abnormal_inflammatory_respons0.79463270
115MP0004947_skin_inflammation0.77673877
116MP0003566_abnormal_cell_adhesion0.77550560
117MP0005171_absent_coat_pigmentation0.76573463
118MP0005330_cardiomyopathy0.75527073
119MP0005164_abnormal_response_to0.74984760
120MP0000003_abnormal_adipose_tissue0.74878660
121MP0002971_abnormal_brown_adipose0.73907266
122MP0005451_abnormal_body_composition0.73770443
123MP0005666_abnormal_adipose_tissue0.73727137
124MP0000358_abnormal_cell_content/0.72834616
125MP0000920_abnormal_myelination0.72604463
126MP0001661_extended_life_span0.72226875
127MP0001672_abnormal_embryogenesis/_devel0.72164695
128MP0005380_embryogenesis_phenotype0.72164695
129MP0004087_abnormal_muscle_fiber0.71682115
130MP0000598_abnormal_liver_morphology0.71088035
131MP0005165_increased_susceptibility_to0.70909045
132MP0000609_abnormal_liver_physiology0.70785150
133MP0008004_abnormal_stomach_pH0.69645390
134MP0005377_hearing/vestibular/ear_phenot0.68997643
135MP0003878_abnormal_ear_physiology0.68997643
136MP0009764_decreased_sensitivity_to0.68925377
137MP0000678_abnormal_parathyroid_gland0.68687072
138MP0001756_abnormal_urination0.68664633
139MP0006138_congestive_heart_failure0.68544757
140MP0000858_altered_metastatic_potential0.68526050
141MP0002088_abnormal_embryonic_growth/wei0.68468428
142MP0009931_abnormal_skin_appearance0.67753759
143MP0000733_abnormal_muscle_development0.67493373
144MP0003984_embryonic_growth_retardation0.67165206
145MP0001697_abnormal_embryo_size0.66777485
146MP0002135_abnormal_kidney_morphology0.66686859
147MP0003879_abnormal_hair_cell0.66533846
148MP0003300_gastrointestinal_ulcer0.65956068
149MP0002080_prenatal_lethality0.65859000
150MP0005390_skeleton_phenotype0.65433940
151MP0010368_abnormal_lymphatic_system0.65329367
152MP0008932_abnormal_embryonic_tissue0.65076819
153MP0005023_abnormal_wound_healing0.64908871
154MP0003075_altered_response_to0.64575411
155MP0002998_abnormal_bone_remodeling0.63795628
156MP0002249_abnormal_larynx_morphology0.63671522
157MP0000249_abnormal_blood_vessel0.63396582

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.34906114
2Absent/shortened dynein arms (HP:0200106)6.01351744
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.01351744
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.99591264
5Glomerulonephritis (HP:0000099)5.42010828
6Abnormality of liposaccharide metabolism (HP:0010968)4.86047471
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.86047471
8Abnormality of glycolipid metabolism (HP:0010969)4.86047471
9Increased cerebral lipofuscin (HP:0011813)4.65413889
10Protrusio acetabuli (HP:0003179)4.35101822
11Abnormal respiratory epithelium morphology (HP:0012253)4.04563269
12Abnormal respiratory motile cilium morphology (HP:0005938)4.04563269
13Infertility (HP:0000789)3.99547327
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.88793379
15Disinhibition (HP:0000734)3.84782696
16Complement deficiency (HP:0004431)3.79778786
17Recurrent abscess formation (HP:0002722)3.78109735
18Nasal polyposis (HP:0100582)3.75625816
19Vertebral compression fractures (HP:0002953)3.73732573
20Abnormal respiratory motile cilium physiology (HP:0012261)3.72468416
21Male infertility (HP:0003251)3.69467179
22Personality changes (HP:0000751)3.61618630
23Vacuolated lymphocytes (HP:0001922)3.58524307
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.53269795
25Increased connective tissue (HP:0009025)3.51769945
26Abnormality of the nasal mucosa (HP:0000433)3.47879908
27Abnormal spermatogenesis (HP:0008669)3.46817051
28Recurrent bacterial skin infections (HP:0005406)3.42507292
29Impulsivity (HP:0100710)3.41078808
30Rhinitis (HP:0012384)3.35701665
31Abnormality of complement system (HP:0005339)3.34579672
32Agnosia (HP:0010524)3.29894255
33Dysostosis multiplex (HP:0000943)3.29412700
34Chronic bronchitis (HP:0004469)3.18448988
35Global brain atrophy (HP:0002283)3.09940638
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01705011
37Cerebral aneurysm (HP:0004944)2.96996357
38Retinal atrophy (HP:0001105)2.94697563
39Nuclear cataract (HP:0100018)2.94443524
40Mutism (HP:0002300)2.92175131
41Poikilocytosis (HP:0004447)2.91274944
42Pustule (HP:0200039)2.83850312
43Cholecystitis (HP:0001082)2.79175532
44Abnormal gallbladder physiology (HP:0012438)2.79175532
45Cervical subluxation (HP:0003308)2.77403276
46Upper motor neuron abnormality (HP:0002127)2.76187429
47Axonal loss (HP:0003447)2.73812910
48Nephritis (HP:0000123)2.67259551
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.63857566
50Bladder diverticulum (HP:0000015)2.62385134
51Polycythemia (HP:0001901)2.60801154
52Osteolytic defects of the hand bones (HP:0009699)2.56525120
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.56525120
54Cholelithiasis (HP:0001081)2.55398585
55Ankle contracture (HP:0006466)2.53858959
56Type 1 muscle fiber predominance (HP:0003803)2.51462667
57Azoospermia (HP:0000027)2.51137269
58Spinal rigidity (HP:0003306)2.50879218
59Achilles tendon contracture (HP:0001771)2.48370702
60Joint stiffness (HP:0001387)2.48183618
61Hepatosplenomegaly (HP:0001433)2.45879312
62Loss of speech (HP:0002371)2.45683383
63Soft skin (HP:0000977)2.45507724
64Increased variability in muscle fiber diameter (HP:0003557)2.43775151
65Neurofibrillary tangles (HP:0002185)2.42348409
66Asymmetric septal hypertrophy (HP:0001670)2.39965611
67Premature rupture of membranes (HP:0001788)2.39288517
68Wormian bones (HP:0002645)2.36436351
69Genu recurvatum (HP:0002816)2.34492190
70Reticulocytosis (HP:0001923)2.33983027
71Abnormal ciliary motility (HP:0012262)2.29827241
72Fragile skin (HP:0001030)2.29237803
73Shallow orbits (HP:0000586)2.26300966
74Cerebral inclusion bodies (HP:0100314)2.26271504
75Hematochezia (HP:0002573)2.24594367
76Conjunctival telangiectasia (HP:0000524)2.23814231
77Dilatation of the ascending aorta (HP:0005111)2.23677566
78Insomnia (HP:0100785)2.23451115
79J-shaped sella turcica (HP:0002680)2.20966558
80Spinal muscular atrophy (HP:0007269)2.20279772
81Blue sclerae (HP:0000592)2.19592437
82Mucopolysacchariduria (HP:0008155)2.18825541
83Urinary glycosaminoglycan excretion (HP:0003541)2.18825541
84Slender build (HP:0001533)2.18325514
85Abnormal gallbladder morphology (HP:0012437)2.15626992
86Abnormality of the Achilles tendon (HP:0005109)2.15182375
87Abnormality of macrophages (HP:0004311)2.15142994
88Recurrent gram-negative bacterial infections (HP:0005420)2.14144596
89Abnormality of the vasculature of the conjunctiva (HP:0008054)2.11862971
90Birth length less than 3rd percentile (HP:0003561)2.11310991
91Abnormal hemoglobin (HP:0011902)2.10424835
92Biconcave vertebral bodies (HP:0004586)2.09488890
93Distal upper limb amyotrophy (HP:0007149)2.09440332
94Upper limb amyotrophy (HP:0009129)2.09440332
95Abnormality of the anterior horn cell (HP:0006802)2.08741427
96Degeneration of anterior horn cells (HP:0002398)2.08741427
97Aortic dissection (HP:0002647)2.08240648
98Abnormality of skeletal muscle fiber size (HP:0012084)2.08210398
99Pathologic fracture (HP:0002756)2.07413224
100Obstructive sleep apnea (HP:0002870)2.06536803
101Aneurysm (HP:0002617)2.05808464
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04569220
103Abnormality of polysaccharide metabolism (HP:0011012)2.04569220
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04569220
105Spondylolisthesis (HP:0003302)2.02678710
106Eczematoid dermatitis (HP:0000976)2.02499560
107Bronchitis (HP:0012387)2.02328344
108Distal lower limb muscle weakness (HP:0009053)2.01471950
109Carpal bone hypoplasia (HP:0001498)2.01079180
110Peripheral demyelination (HP:0011096)1.99655932
111Bronchiectasis (HP:0002110)1.99189710
112Neuronal loss in central nervous system (HP:0002529)1.99016557
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97841711
114Microcytic anemia (HP:0001935)1.96628233
115Broad metatarsal (HP:0001783)1.93774332
116Deformed sella turcica (HP:0002681)1.92298125
117Absent epiphyses (HP:0010577)1.90519240
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90519240
119Breast hypoplasia (HP:0003187)1.90281379
120Spontaneous hematomas (HP:0007420)1.89406875
121Petechiae (HP:0000967)1.88394505
122Thin bony cortex (HP:0002753)1.87616457
123Spastic tetraparesis (HP:0001285)1.87602337
124Atrophic scars (HP:0001075)1.86941698
125Mitral regurgitation (HP:0001653)1.84112843
126Abnormality of dentin (HP:0010299)1.83490442
127Disproportionate tall stature (HP:0001519)1.83420862
128Venous abnormality (HP:0002624)1.83254450
129Paralysis (HP:0003470)1.83049846
130Hypertensive crisis (HP:0100735)1.82806244
131Generalized amyotrophy (HP:0003700)1.81918599
132Hyperacusis (HP:0010780)1.81345359
133Joint laxity (HP:0001388)1.81208946
134Abnormality of the gallbladder (HP:0005264)1.80928349
135Arterial tortuosity (HP:0005116)1.80357489
136Hyperextensible skin (HP:0000974)1.79980286
137Aortic aneurysm (HP:0004942)1.78920419
138Myocardial infarction (HP:0001658)1.78564678
139Distal lower limb amyotrophy (HP:0008944)1.77395233
140Urethral obstruction (HP:0000796)1.77313897
141Elbow flexion contracture (HP:0002987)1.77134487
142Increased serum ferritin (HP:0003281)1.77018917
143Abnormality of the thoracic spine (HP:0100711)1.75015341
144Round ear (HP:0100830)1.74947931
145Nausea (HP:0002018)1.74815639
146Myositis (HP:0100614)1.72199673
147Impaired platelet aggregation (HP:0003540)1.70057219
148Abnormal platelet function (HP:0011869)1.70057219
149Nonimmune hydrops fetalis (HP:0001790)1.69752780
150Diaphragmatic weakness (HP:0009113)1.69231713
151Abnormality of the umbilical cord (HP:0010881)1.68479531
152Segmental peripheral demyelination/remyelination (HP:0003481)1.68013762
153Progressive neurologic deterioration (HP:0002344)1.67519380
154Acanthocytosis (HP:0001927)1.66651736
155Neurodegeneration (HP:0002180)1.64108319
156Thoracic kyphosis (HP:0002942)1.63926107
157Autoimmune thrombocytopenia (HP:0001973)1.63043554
158Abnormality of reticulocytes (HP:0004312)1.59824650
159Vascular tortuosity (HP:0004948)1.59716228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.19119929
2PDK44.11592294
3PDK34.11592294
4TGFBR23.93842603
5TESK13.46171094
6BUB13.06793605
7NEK22.98975117
8DDR22.75323993
9PRPF4B2.71902722
10TAOK22.59852811
11ICK2.48416800
12EIF2AK12.40893350
13PRKD32.32924542
14WEE12.26447380
15SIK12.25504453
16RIPK12.22039139
17PDGFRA2.06382407
18BLK1.82929940
19NME21.78223906
20CSF1R1.75467016
21TTK1.74914459
22SMG11.72883770
23CDC42BPA1.64873692
24TSSK61.61793846
25TTN1.55666854
26TYK21.55228327
27PAK41.52371133
28BMX1.50347559
29ABL21.45291889
30STK101.44410573
31TRIB31.42714639
32DYRK31.41446226
33RIPK41.39460176
34LATS21.36095061
35STK31.34169480
36PLK41.33379758
37KIT1.31447402
38KDR1.30392233
39MAP2K31.28445093
40MAPK151.28010113
41BRSK21.26201638
42MAP3K11.21117719
43NEK91.19906180
44MAP3K61.19754075
45ERN11.19511731
46PRKD21.17786213
47GRK71.15243230
48EEF2K1.09207923
49IRAK31.08019813
50MYLK1.07455717
51KSR21.07057941
52RPS6KA21.05777329
53CDK121.05441084
54PTK2B1.03693214
55TBK11.03267236
56ZAP701.02185388
57MARK21.02151041
58BRSK11.01531244
59PKN21.00527586
60MAP4K10.98901124
61RPS6KA40.97505248
62PLK10.97096496
63PDK10.96167335
64RPS6KL10.96092029
65RPS6KC10.96092029
66MAP3K30.95914470
67CHEK20.95366271
68EPHB20.91784722
69MAP3K80.91054875
70ZAK0.90856875
71DYRK1B0.88398547
72STK380.87881445
73TLK10.84218383
74CAMK1D0.83838525
75VRK10.83734901
76PIM10.82718350
77PTK20.82354136
78CDK40.82081679
79NTRK10.80983802
80CAMKK20.79284283
81STK40.78662580
82CCNB10.77431562
83EPHB10.76757324
84SCYL20.76359535
85IRAK40.75885596
86PRKG20.74001666
87BRAF0.73300286
88DMPK0.73095206
89PDPK10.72966070
90EPHA20.72378666
91MOS0.71342988
92CLK10.70700475
93PLK30.70587347
94RPS6KA60.70040553
95MAP3K130.68423280
96PAK10.67984860
97CDK60.67277845
98PNCK0.62568499
99ARAF0.61099596
100IKBKB0.60811967
101TESK20.59807750
102AURKA0.59777419
103CAMK1G0.58247832
104HIPK20.57989583
105CDC70.57641851
106MAPK70.57482278
107DAPK30.57365281
108PAK20.55991195
109JAK30.55806302
110AURKB0.55035945
111FGR0.54686484
112MAPK40.54013260
113TRPM70.53652370
114IRAK20.53173312
115PIM20.52527592
116LYN0.52274634
117PDGFRB0.51636141
118MAP2K20.50648080
119JAK20.48347958
120PRKAA20.47633181
121CAMKK10.43675551
122MAP3K100.43284880
123PTK60.42486822
124MAP2K10.41582193
125MATK0.41515763
126TIE10.41121554
127MTOR0.41070605
128ATR0.40714693
129CSK0.40486668
130TAOK10.40460169
131HCK0.40334238
132MAPK120.40097317
133ROCK10.37774696
134MAP3K70.36589534
135LIMK10.36139103
136PRKD10.35607257
137ILK0.35502547
138GSK3A0.35424788
139MARK30.35202366
140TYRO30.34285111
141EIF2AK20.34200575
142NEK10.33951930
143MAP3K110.33440427
144GRK60.32965657
145CHEK10.32765335
146JAK10.31473963
147MELK0.30183666
148MAPKAPK50.30149297
149PINK10.30043139
150SYK0.28550937
151MAPKAPK30.28064951
152MAPKAPK20.25409214

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.61952357
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.92530258
3Other glycan degradation_Homo sapiens_hsa005113.23713207
4Staphylococcus aureus infection_Homo sapiens_hsa051503.15125904
5Lysosome_Homo sapiens_hsa041422.96485377
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.27593539
7Antigen processing and presentation_Homo sapiens_hsa046122.10721402
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.96696416
9DNA replication_Homo sapiens_hsa030301.92463264
10Cell cycle_Homo sapiens_hsa041101.86491909
11Bladder cancer_Homo sapiens_hsa052191.84660828
12RNA transport_Homo sapiens_hsa030131.71042652
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.59817916
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49697051
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49198735
16Acute myeloid leukemia_Homo sapiens_hsa052211.48797159
17Systemic lupus erythematosus_Homo sapiens_hsa053221.45597482
18Osteoclast differentiation_Homo sapiens_hsa043801.44987875
19Pentose phosphate pathway_Homo sapiens_hsa000301.41972283
20Legionellosis_Homo sapiens_hsa051341.40843413
21Proteasome_Homo sapiens_hsa030501.40817770
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40385358
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39289156
24Basal transcription factors_Homo sapiens_hsa030221.38612783
25ECM-receptor interaction_Homo sapiens_hsa045121.37545691
26Regulation of autophagy_Homo sapiens_hsa041401.36341375
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34246797
28Amoebiasis_Homo sapiens_hsa051461.33375467
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27792028
30Focal adhesion_Homo sapiens_hsa045101.27556306
31Notch signaling pathway_Homo sapiens_hsa043301.27448935
32Pyrimidine metabolism_Homo sapiens_hsa002401.24817256
33Galactose metabolism_Homo sapiens_hsa000521.24594357
34RNA polymerase_Homo sapiens_hsa030201.21762920
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.17247424
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15541554
37Malaria_Homo sapiens_hsa051441.14585658
38Base excision repair_Homo sapiens_hsa034101.11170616
39B cell receptor signaling pathway_Homo sapiens_hsa046621.10148750
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08905754
41TNF signaling pathway_Homo sapiens_hsa046681.06087515
42VEGF signaling pathway_Homo sapiens_hsa043701.05100231
43Fanconi anemia pathway_Homo sapiens_hsa034601.04504989
44p53 signaling pathway_Homo sapiens_hsa041151.04082258
45Epstein-Barr virus infection_Homo sapiens_hsa051691.03709381
46Leishmaniasis_Homo sapiens_hsa051401.03003784
47Vibrio cholerae infection_Homo sapiens_hsa051101.02959865
48Complement and coagulation cascades_Homo sapiens_hsa046101.02877401
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.01914420
50Fructose and mannose metabolism_Homo sapiens_hsa000511.00589089
51Phagosome_Homo sapiens_hsa041450.99313544
52Tuberculosis_Homo sapiens_hsa051520.98737837
53Prion diseases_Homo sapiens_hsa050200.98542622
54Oocyte meiosis_Homo sapiens_hsa041140.97713983
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97639986
56Endocytosis_Homo sapiens_hsa041440.96709965
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96517300
58Renal cell carcinoma_Homo sapiens_hsa052110.96516188
59Measles_Homo sapiens_hsa051620.95051228
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92119000
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90772563
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90759843
63Purine metabolism_Homo sapiens_hsa002300.89358322
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88066590
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87719770
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87183961
67Pertussis_Homo sapiens_hsa051330.86753858
68Mismatch repair_Homo sapiens_hsa034300.86321343
69mTOR signaling pathway_Homo sapiens_hsa041500.86190150
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85507804
71Collecting duct acid secretion_Homo sapiens_hsa049660.84219389
72Apoptosis_Homo sapiens_hsa042100.82679689
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.82421341
74Homologous recombination_Homo sapiens_hsa034400.82175169
75Toxoplasmosis_Homo sapiens_hsa051450.81387118
76Protein digestion and absorption_Homo sapiens_hsa049740.81190764
77Non-small cell lung cancer_Homo sapiens_hsa052230.80905534
78Proteoglycans in cancer_Homo sapiens_hsa052050.80539120
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.80232249
80Nucleotide excision repair_Homo sapiens_hsa034200.79890246
81Herpes simplex infection_Homo sapiens_hsa051680.79398811
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78930836
83Influenza A_Homo sapiens_hsa051640.78612597
84Viral carcinogenesis_Homo sapiens_hsa052030.78508565
85Mineral absorption_Homo sapiens_hsa049780.77285205
86Selenocompound metabolism_Homo sapiens_hsa004500.75709581
87Arachidonic acid metabolism_Homo sapiens_hsa005900.74437270
88Vitamin digestion and absorption_Homo sapiens_hsa049770.73990807
89Folate biosynthesis_Homo sapiens_hsa007900.73852473
90Glioma_Homo sapiens_hsa052140.73285937
91Spliceosome_Homo sapiens_hsa030400.73044375
92Insulin signaling pathway_Homo sapiens_hsa049100.71853270
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70847831
94Linoleic acid metabolism_Homo sapiens_hsa005910.69756223
95GnRH signaling pathway_Homo sapiens_hsa049120.68495372
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.68385601
97Glycerolipid metabolism_Homo sapiens_hsa005610.67525390
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66840458
99Hepatitis C_Homo sapiens_hsa051600.66597958
100AMPK signaling pathway_Homo sapiens_hsa041520.65229758
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64123486
102Renin-angiotensin system_Homo sapiens_hsa046140.63633042
103MicroRNAs in cancer_Homo sapiens_hsa052060.63314360
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62736185
105Fatty acid biosynthesis_Homo sapiens_hsa000610.62195151
106Synaptic vesicle cycle_Homo sapiens_hsa047210.60713522
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.60611368
108Dilated cardiomyopathy_Homo sapiens_hsa054140.60521156
109Shigellosis_Homo sapiens_hsa051310.59902892
110Melanoma_Homo sapiens_hsa052180.59842697
111Chronic myeloid leukemia_Homo sapiens_hsa052200.58153966
112Glutathione metabolism_Homo sapiens_hsa004800.57486870
113African trypanosomiasis_Homo sapiens_hsa051430.57182581
114Hematopoietic cell lineage_Homo sapiens_hsa046400.56583965
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56425818
116Rheumatoid arthritis_Homo sapiens_hsa053230.55874489
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55036405
118Prolactin signaling pathway_Homo sapiens_hsa049170.54961237
119Estrogen signaling pathway_Homo sapiens_hsa049150.54832015
120Ether lipid metabolism_Homo sapiens_hsa005650.52245882
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52215175
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51597432
123Hepatitis B_Homo sapiens_hsa051610.51485805
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.50971838
125Prostate cancer_Homo sapiens_hsa052150.50801367
126HIF-1 signaling pathway_Homo sapiens_hsa040660.50339513
127Sphingolipid metabolism_Homo sapiens_hsa006000.50000310
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49788291
129Insulin resistance_Homo sapiens_hsa049310.49213498
130PPAR signaling pathway_Homo sapiens_hsa033200.47816281
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46855642
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46609114
133Endometrial cancer_Homo sapiens_hsa052130.45621831
134Salmonella infection_Homo sapiens_hsa051320.45621798
135Sulfur relay system_Homo sapiens_hsa041220.44676879
136HTLV-I infection_Homo sapiens_hsa051660.43857781
137Small cell lung cancer_Homo sapiens_hsa052220.43265787
138ABC transporters_Homo sapiens_hsa020100.42563754
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41783193
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.41433598
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41352325
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39472121
143ErbB signaling pathway_Homo sapiens_hsa040120.39433351
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39423346
145Thyroid cancer_Homo sapiens_hsa052160.38832763
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38611373
147Pancreatic cancer_Homo sapiens_hsa052120.37711952
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.37516471
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.37192627
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.34618438
151Fat digestion and absorption_Homo sapiens_hsa049750.31782982
152Inositol phosphate metabolism_Homo sapiens_hsa005620.30896669

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