RAB3IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)6.58609368
2lysine catabolic process (GO:0006554)6.58609368
3drug transmembrane transport (GO:0006855)5.67019009
4tricarboxylic acid cycle (GO:0006099)5.56852244
5urate metabolic process (GO:0046415)5.41931785
6aminoglycoside antibiotic metabolic process (GO:0030647)5.33172500
7phosphate ion transport (GO:0006817)5.10306666
8aspartate family amino acid catabolic process (GO:0009068)5.03724751
9organic cation transport (GO:0015695)4.99062474
102-oxoglutarate metabolic process (GO:0006103)4.90084378
11quaternary ammonium group transport (GO:0015697)4.77435886
12drug transport (GO:0015893)4.77063725
13glyoxylate metabolic process (GO:0046487)4.69646175
14NADH metabolic process (GO:0006734)4.63898587
15tricarboxylic acid metabolic process (GO:0072350)4.60569320
16amino-acid betaine transport (GO:0015838)4.57159503
17carnitine transport (GO:0015879)4.57159503
18phosphate ion transmembrane transport (GO:0035435)4.56225045
19cysteine metabolic process (GO:0006534)4.52878318
20short-chain fatty acid metabolic process (GO:0046459)4.47806680
21response to mercury ion (GO:0046689)4.43847724
22response to pheromone (GO:0019236)4.31640356
23serine family amino acid catabolic process (GO:0009071)4.14562172
24fatty acid beta-oxidation (GO:0006635)4.04115364
25postsynaptic membrane organization (GO:0001941)4.01815454
26regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.00706529
27cellular ketone body metabolic process (GO:0046950)3.99347842
28drug catabolic process (GO:0042737)3.91905328
29regulation of cofactor metabolic process (GO:0051193)3.89998483
30regulation of coenzyme metabolic process (GO:0051196)3.89998483
31regulation of acyl-CoA biosynthetic process (GO:0050812)3.83591419
32protein polyglutamylation (GO:0018095)3.83111881
33exogenous drug catabolic process (GO:0042738)3.82269204
34homocysteine metabolic process (GO:0050667)3.80065544
35piRNA metabolic process (GO:0034587)3.77907070
36regulation of cilium movement (GO:0003352)3.73405374
37L-phenylalanine metabolic process (GO:0006558)3.72933749
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.72933749
39gamma-aminobutyric acid transport (GO:0015812)3.72435945
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71963185
41branched-chain amino acid metabolic process (GO:0009081)3.70209506
42presynaptic membrane assembly (GO:0097105)3.68298902
43neuron cell-cell adhesion (GO:0007158)3.63546398
44excretion (GO:0007588)3.62627335
45carnitine shuttle (GO:0006853)3.62011155
46acetyl-CoA metabolic process (GO:0006084)3.59846867
47carnitine transmembrane transport (GO:1902603)3.59480030
48acrosome reaction (GO:0007340)3.57185909
49amino-acid betaine metabolic process (GO:0006577)3.56249035
50fatty acid oxidation (GO:0019395)3.54077458
51sarcomere organization (GO:0045214)3.53324931
52proline metabolic process (GO:0006560)3.53071459
53serine family amino acid metabolic process (GO:0009069)3.51966131
54ventricular cardiac muscle cell action potential (GO:0086005)3.50360889
55renal absorption (GO:0070293)3.47824189
56oxaloacetate metabolic process (GO:0006107)3.46814723
57branched-chain amino acid catabolic process (GO:0009083)3.44021043
58synapsis (GO:0007129)3.43486565
59lipid oxidation (GO:0034440)3.43035099
60presynaptic membrane organization (GO:0097090)3.41971057
61cellular modified amino acid catabolic process (GO:0042219)3.41805235
62fructose metabolic process (GO:0006000)3.41654735
634-hydroxyproline metabolic process (GO:0019471)3.40947436
64valine metabolic process (GO:0006573)3.39857733
65ketone body metabolic process (GO:1902224)3.38162659
66establishment of protein localization to Golgi (GO:0072600)3.36872570
67oxidative phosphorylation (GO:0006119)3.36107782
68sperm motility (GO:0030317)3.36097496
69kynurenine metabolic process (GO:0070189)3.34993547
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34773191
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34004617
72fatty acid catabolic process (GO:0009062)3.32908836
73succinate metabolic process (GO:0006105)3.32384163
74membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.28301588
75negative regulation of potassium ion transmembrane transport (GO:1901380)3.24649789
76positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.21880435
77male meiosis I (GO:0007141)3.21002758
78carnitine metabolic process (GO:0009437)3.20682263
79gap junction assembly (GO:0016264)3.19319343
80negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.16888757
81fatty acid transmembrane transport (GO:1902001)3.16458851
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16301309
83L-phenylalanine catabolic process (GO:0006559)3.16301309
84gluconeogenesis (GO:0006094)3.16293439
85aromatic amino acid family catabolic process (GO:0009074)3.13783754
86indole-containing compound catabolic process (GO:0042436)3.12663168
87indolalkylamine catabolic process (GO:0046218)3.12663168
88tryptophan catabolic process (GO:0006569)3.12663168
89cell communication by electrical coupling (GO:0010644)3.12142841
90protein targeting to Golgi (GO:0000042)3.11225332
91bundle of His cell to Purkinje myocyte communication (GO:0086069)3.10195362
92hexose biosynthetic process (GO:0019319)3.09882999
93modified amino acid transport (GO:0072337)3.08368745
94monocarboxylic acid catabolic process (GO:0072329)3.06190542
95DNA methylation involved in gamete generation (GO:0043046)3.06023560
96axoneme assembly (GO:0035082)3.04793437
97regulation of microtubule-based movement (GO:0060632)3.03385036
98regulation of sulfur metabolic process (GO:0042762)3.01936827
99sulfur amino acid catabolic process (GO:0000098)2.98988105
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98850918
101epithelial cilium movement (GO:0003351)2.97843390
102dicarboxylic acid metabolic process (GO:0043648)2.97425086
103alpha-amino acid catabolic process (GO:1901606)2.97327237
104ATP synthesis coupled proton transport (GO:0015986)2.95919945
105energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95919945
106cardiac myofibril assembly (GO:0055003)2.94774206
107cellular amino acid catabolic process (GO:0009063)2.94388749
108regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94301319
109regulation of meiosis I (GO:0060631)2.92600289
110respiratory electron transport chain (GO:0022904)2.92281992
111membrane repolarization during action potential (GO:0086011)2.90118003
112cardiac muscle contraction (GO:0060048)2.88796929
113retrograde transport, vesicle recycling within Golgi (GO:0000301)2.88253911
114cell communication involved in cardiac conduction (GO:0086065)2.87451349
115calcium ion-dependent exocytosis (GO:0017156)2.86558478
116electron transport chain (GO:0022900)2.85895715
117nonmotile primary cilium assembly (GO:0035058)2.85687746
118vitamin D metabolic process (GO:0042359)2.84990230
119male meiosis (GO:0007140)2.84974631
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84510801
121organic acid catabolic process (GO:0016054)2.83391943
122carboxylic acid catabolic process (GO:0046395)2.83391943
123tryptophan metabolic process (GO:0006568)2.83376144
124glutamate metabolic process (GO:0006536)2.83015509
125biotin metabolic process (GO:0006768)2.82822695
126protein localization to synapse (GO:0035418)2.79972241
127serine family amino acid biosynthetic process (GO:0009070)2.79950795
128regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79099628
129protein K11-linked deubiquitination (GO:0035871)2.78484058
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78019653
131vocalization behavior (GO:0071625)2.77826120
132positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77022531
133spermatid development (GO:0007286)2.76895138
134cilium movement (GO:0003341)2.76536551
135protein localization to Golgi apparatus (GO:0034067)2.74582264
136behavioral response to nicotine (GO:0035095)2.73336054
137mechanosensory behavior (GO:0007638)2.72743984
138synaptic transmission, glutamatergic (GO:0035249)2.71052683
139regulation of sarcomere organization (GO:0060297)2.69838395
140C4-dicarboxylate transport (GO:0015740)2.69329492
141ionotropic glutamate receptor signaling pathway (GO:0035235)2.68120170
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66555604
143neuronal action potential propagation (GO:0019227)2.66370602
144positive regulation of meiosis (GO:0045836)2.65286788
145glycosphingolipid biosynthetic process (GO:0006688)2.62608980
146* cilium organization (GO:0044782)2.61881930
147* cilium assembly (GO:0042384)2.61814499
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61479495
149protein localization to cilium (GO:0061512)2.59737897
150neurotransmitter secretion (GO:0007269)2.59705300
151glutamate receptor signaling pathway (GO:0007215)2.58999196
152synaptic vesicle maturation (GO:0016188)2.58213589
153negative regulation of neurotransmitter transport (GO:0051589)2.57437402
154chromosome organization involved in meiosis (GO:0070192)2.56853246
155photoreceptor cell maintenance (GO:0045494)2.56539049
156microtubule depolymerization (GO:0007019)2.55633857
157cilium or flagellum-dependent cell motility (GO:0001539)2.55396539
158transmission of nerve impulse (GO:0019226)2.54234630
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54104679
160retinal cone cell development (GO:0046549)2.53847705
161positive regulation of oligodendrocyte differentiation (GO:0048714)2.52675590
162reciprocal meiotic recombination (GO:0007131)2.52388374
163reciprocal DNA recombination (GO:0035825)2.52388374
164detection of light stimulus involved in sensory perception (GO:0050962)2.51535266
165detection of light stimulus involved in visual perception (GO:0050908)2.51535266
166negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50308665
167microtubule polymerization or depolymerization (GO:0031109)2.50133321
168synapse assembly (GO:0007416)2.48622372
169positive regulation of meiotic cell cycle (GO:0051446)2.48329675
170regulation of short-term neuronal synaptic plasticity (GO:0048172)2.47023667
171central nervous system myelination (GO:0022010)2.46673330
172axon ensheathment in central nervous system (GO:0032291)2.46673330
173regulation of neurotransmitter uptake (GO:0051580)2.46299159
174intraciliary transport (GO:0042073)2.44405065
175neurotransmitter-gated ion channel clustering (GO:0072578)2.41897273
176reflex (GO:0060004)2.41143619
177nucleobase catabolic process (GO:0046113)2.41046230
178centriole replication (GO:0007099)2.41045041
179Golgi to endosome transport (GO:0006895)2.39832082
180neuron-neuron synaptic transmission (GO:0007270)2.37941088
181pyrimidine nucleobase catabolic process (GO:0006208)2.37219056
182axonemal dynein complex assembly (GO:0070286)2.36594215
183neuronal ion channel clustering (GO:0045161)2.35914138
184single strand break repair (GO:0000012)2.35868774
185retina layer formation (GO:0010842)2.32575138
186proline transport (GO:0015824)2.30437474
187meiosis I (GO:0007127)2.30426913
188cAMP catabolic process (GO:0006198)2.30352367
189insulin secretion (GO:0030073)2.29284506
190L-fucose catabolic process (GO:0042355)2.28322975
191fucose catabolic process (GO:0019317)2.28322975
192L-fucose metabolic process (GO:0042354)2.28322975
193spinal cord motor neuron differentiation (GO:0021522)2.28224250
194limb development (GO:0060173)2.27980634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.79031350
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.45970757
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.99577847
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.77042306
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.46942370
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.28252073
7GBX2_23144817_ChIP-Seq_PC3_Human3.20143313
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.97905173
9ZNF263_19887448_ChIP-Seq_K562_Human2.91364948
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.85679205
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78481888
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.62391824
13FUS_26573619_Chip-Seq_HEK293_Human2.54746345
14EZH2_22144423_ChIP-Seq_EOC_Human2.47367607
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46588875
16NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.43891681
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41995535
18IGF1R_20145208_ChIP-Seq_DFB_Human2.41851435
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41604748
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37537934
21TAF15_26573619_Chip-Seq_HEK293_Human2.33849079
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17255062
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12451802
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11531602
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10075845
26P300_19829295_ChIP-Seq_ESCs_Human2.07777091
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05412867
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04223063
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96786821
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95830859
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.94536060
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.93661004
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87072567
34AR_21909140_ChIP-Seq_LNCAP_Human1.86893668
35VDR_22108803_ChIP-Seq_LS180_Human1.85937078
36ER_23166858_ChIP-Seq_MCF-7_Human1.84662336
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80625510
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78571609
39* STAT3_23295773_ChIP-Seq_U87_Human1.78182332
40EWS_26573619_Chip-Seq_HEK293_Human1.77349484
41REST_21632747_ChIP-Seq_MESCs_Mouse1.76794690
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.75888841
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72548998
44CLOCK_20551151_ChIP-Seq_293T_Human1.70374950
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68646599
46CBP_20019798_ChIP-Seq_JUKART_Human1.68646599
47AR_25329375_ChIP-Seq_VCAP_Human1.67562321
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66774053
49TCF4_23295773_ChIP-Seq_U87_Human1.65201502
50* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65017878
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64621304
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.63438968
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61457591
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61164005
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52950256
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52359028
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.51545340
58* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49561555
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48720632
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48644164
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47765327
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47765327
63BCAT_22108803_ChIP-Seq_LS180_Human1.47606496
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47105768
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.46081692
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.46081692
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43736409
68* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43177511
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42321825
70* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41547509
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41175413
72RNF2_27304074_Chip-Seq_NSC_Mouse1.40792234
73GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.40197782
74* ATF3_27146783_Chip-Seq_COLON_Human1.38077768
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37434719
76* RUNX2_22187159_ChIP-Seq_PCA_Human1.36383403
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.35423065
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.34286296
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32937394
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.31545790
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.30994106
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30746126
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30532912
84* SMAD4_21741376_ChIP-Seq_EPCs_Human1.29952283
85IRF1_19129219_ChIP-ChIP_H3396_Human1.29623553
86* TCF4_22108803_ChIP-Seq_LS180_Human1.29490531
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.29362557
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28784001
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28611373
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25086079
91MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24863251
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.24456033
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22164445
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21782062
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.20909028
96SOX2_19829295_ChIP-Seq_ESCs_Human1.18485195
97NANOG_19829295_ChIP-Seq_ESCs_Human1.18485195
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17813660
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.17516637
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17312703
101TP53_22573176_ChIP-Seq_HFKS_Human1.15686033
102AR_21572438_ChIP-Seq_LNCaP_Human1.14981101
103* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14802970
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14618201
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14445819
106* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14421867
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12932374
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12883164
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12503303
110TRIM28_21343339_ChIP-Seq_HEK293_Human1.11786864
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11514399
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11486623
113P53_22387025_ChIP-Seq_ESCs_Mouse1.11271164
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10168665
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.08981781
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.08756679
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08578526
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08545396
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07327523
120CDX2_22108803_ChIP-Seq_LS180_Human1.07306530
121HNF4A_19822575_ChIP-Seq_HepG2_Human1.06549888
122ZNF274_21170338_ChIP-Seq_K562_Hela1.06444987
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.06286618
124* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05971031
125AHR_22903824_ChIP-Seq_MCF-7_Human1.05948359
126CREB1_26743006_Chip-Seq_LNCaP_Human1.05018851
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04911519
128EZH2_27304074_Chip-Seq_ESCs_Mouse1.04731319
129ESR1_21235772_ChIP-Seq_MCF-7_Human1.04232578
130P68_20966046_ChIP-Seq_HELA_Human1.03602001
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.03498020
132FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03498020
133* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03444381
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03360830
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03253477
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.03190101
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02641780
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02626813
139TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02255271
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02212506
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02072441
142CTCF_27219007_Chip-Seq_Bcells_Human1.01987261
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00459126
144NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00327618
145TAL1_26923725_Chip-Seq_HPCs_Mouse1.00189945
146WDR5_24793694_ChIP-Seq_LNCAP_Human1.00021336
147CMYC_18555785_Chip-Seq_ESCs_Mouse0.99455496
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99449567
149SMC4_20622854_ChIP-Seq_HELA_Human0.99344711
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98852133
151P300_18555785_Chip-Seq_ESCs_Mouse0.98534240
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98242603
153* TBL1_22424771_ChIP-Seq_293T_Human0.98216171
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.98114056
155* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98032712
156RACK7_27058665_Chip-Seq_MCF-7_Human0.97528313
157LXR_22292898_ChIP-Seq_THP-1_Human0.97413752
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95632836
159POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95002651
160KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94835587
161TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92139412
162SOX2_21211035_ChIP-Seq_LN229_Human0.90720074
163JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90460099
164TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89071326
165GATA6_25053715_ChIP-Seq_YYC3_Human0.89065091
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88882164
167* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88412939
168PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88369297
169* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88162147
170OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87152660
171RAC3_21632823_ChIP-Seq_H3396_Human0.85781900
172ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85534648
173SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85347002
174RUNX1_27514584_Chip-Seq_MCF-7_Human0.85053902
175FOXA2_19822575_ChIP-Seq_HepG2_Human0.84921118
176E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84640656
177FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83674296
178NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82560667
179CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82490832
180SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81699309
181TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81191618
182PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81102673
183CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80568138
184PHF8_20622854_ChIP-Seq_HELA_Human0.80234487
185SMAD3_21741376_ChIP-Seq_HESCs_Human0.79619531
186TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79234698
187SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78970110
188NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78919592
189MYC_18358816_ChIP-ChIP_MESCs_Mouse0.78880271
190FOXP1_21924763_ChIP-Seq_HESCs_Human0.78684927
191SOX11_22085726_ChIP-Seq_ESNs_Mouse0.78415432
192SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78304430
193ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76883116
194SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76872402
195* NANOG_21062744_ChIP-ChIP_HESCs_Human0.76833019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.98953021
2MP0004043_abnormal_pH_regulation4.06442232
3MP0002139_abnormal_hepatobiliary_system3.59162736
4MP0002837_dystrophic_cardiac_calcinosis3.56897202
5MP0003646_muscle_fatigue3.39211347
6MP0005332_abnormal_amino_acid3.15381743
7MP0008877_abnormal_DNA_methylation3.12185829
8MP0004019_abnormal_vitamin_homeostasis2.94409602
9MP0004084_abnormal_cardiac_muscle2.83230656
10MP0004233_abnormal_muscle_weight2.77561427
11MP0003195_calcinosis2.69618698
12MP0003880_abnormal_central_pattern2.65811665
13MP0003252_abnormal_bile_duct2.55552004
14MP0005085_abnormal_gallbladder_physiolo2.52607282
15MP0004215_abnormal_myocardial_fiber2.51091148
16MP0003787_abnormal_imprinting2.44145605
17MP0003806_abnormal_nucleotide_metabolis2.31096246
18MP0009046_muscle_twitch2.30502182
19MP0009643_abnormal_urine_homeostasis2.21872078
20MP0001765_abnormal_ion_homeostasis2.21277697
21MP0005365_abnormal_bile_salt2.18355726
22MP0001968_abnormal_touch/_nociception2.15145922
23MP0008875_abnormal_xenobiotic_pharmacok2.10517316
24MP0009745_abnormal_behavioral_response2.09700155
25MP0005330_cardiomyopathy2.08824946
26MP0004036_abnormal_muscle_relaxation2.06758854
27MP0002272_abnormal_nervous_system2.05902461
28MP0000751_myopathy2.02822482
29MP0002138_abnormal_hepatobiliary_system2.01387720
30MP0003878_abnormal_ear_physiology1.99092725
31MP0005377_hearing/vestibular/ear_phenot1.99092725
32MP0001756_abnormal_urination1.96518949
33MP0001486_abnormal_startle_reflex1.90935998
34MP0006036_abnormal_mitochondrial_physio1.90503417
35MP0005646_abnormal_pituitary_gland1.89477022
36MP0005670_abnormal_white_adipose1.88348863
37MP0002735_abnormal_chemical_nociception1.86583346
38MP0003635_abnormal_synaptic_transmissio1.85350797
39MP0004859_abnormal_synaptic_plasticity1.84190588
40MP0004270_analgesia1.82671063
41MP0000569_abnormal_digit_pigmentation1.76214070
42MP0002064_seizures1.75196385
43MP0005645_abnormal_hypothalamus_physiol1.73313940
44MP0008961_abnormal_basal_metabolism1.71906523
45MP0003221_abnormal_cardiomyocyte_apopto1.69517160
46MP0005636_abnormal_mineral_homeostasis1.66444988
47MP0001501_abnormal_sleep_pattern1.64452418
48MP0009780_abnormal_chondrocyte_physiolo1.61413124
49MP0010234_abnormal_vibrissa_follicle1.60292588
50MP0002102_abnormal_ear_morphology1.60091415
51MP0008057_abnormal_DNA_replication1.59258648
52MP0005253_abnormal_eye_physiology1.57369266
53MP0002734_abnormal_mechanical_nocicepti1.55969667
54MP0002972_abnormal_cardiac_muscle1.55829106
55MP0002572_abnormal_emotion/affect_behav1.55056338
56MP0000750_abnormal_muscle_regeneration1.54679327
57MP0001986_abnormal_taste_sensitivity1.53139500
58MP0002557_abnormal_social/conspecific_i1.52787210
59MP0004147_increased_porphyrin_level1.51792753
60MP0002063_abnormal_learning/memory/cond1.50169736
61MP0000749_muscle_degeneration1.48944048
62MP0002638_abnormal_pupillary_reflex1.48789706
63MP0004087_abnormal_muscle_fiber1.48726392
64MP0000631_abnormal_neuroendocrine_gland1.48365421
65MP0002269_muscular_atrophy1.48034603
66MP0005379_endocrine/exocrine_gland_phen1.46925851
67MP0003698_abnormal_male_reproductive1.46748617
68MP0005620_abnormal_muscle_contractility1.46280515
69MP0006276_abnormal_autonomic_nervous1.44585717
70MP0002733_abnormal_thermal_nociception1.42602315
71MP0004484_altered_response_of1.41120303
72MP0004885_abnormal_endolymph1.39391203
73MP0005666_abnormal_adipose_tissue1.39102786
74MP0001485_abnormal_pinna_reflex1.38704991
75MP0005423_abnormal_somatic_nervous1.38102277
76MP0001970_abnormal_pain_threshold1.37547342
77MP0002822_catalepsy1.37413837
78MP0001929_abnormal_gametogenesis1.36347201
79MP0000778_abnormal_nervous_system1.35460756
80MP0003121_genomic_imprinting1.33862397
81MP0008775_abnormal_heart_ventricle1.33277653
82MP0002067_abnormal_sensory_capabilities1.30392420
83MP0003137_abnormal_impulse_conducting1.30064331
84MP0002136_abnormal_kidney_physiology1.29956332
85MP0000427_abnormal_hair_cycle1.28899002
86MP0002876_abnormal_thyroid_physiology1.28468656
87MP0002928_abnormal_bile_duct1.28100350
88MP0003123_paternal_imprinting1.28077715
89MP0005386_behavior/neurological_phenoty1.26742449
90MP0004924_abnormal_behavior1.26742449
91MP0006035_abnormal_mitochondrial_morpho1.26741080
92MP0005319_abnormal_enzyme/_coenzyme1.25646180
93MP0006138_congestive_heart_failure1.25608238
94MP0002160_abnormal_reproductive_system1.25525014
95MP0010630_abnormal_cardiac_muscle1.25038660
96MP0006072_abnormal_retinal_apoptosis1.24982906
97MP0005410_abnormal_fertilization1.21741682
98MP0000383_abnormal_hair_follicle1.21673170
99MP0001529_abnormal_vocalization1.21662782
100MP0004264_abnormal_extraembryonic_tissu1.20879854
101MP0002210_abnormal_sex_determination1.20828764
102MP0001502_abnormal_circadian_rhythm1.19211198
103MP0005385_cardiovascular_system_phenoty1.18658018
104MP0001544_abnormal_cardiovascular_syste1.18658018
105MP0004142_abnormal_muscle_tone1.15862900
106MP0004130_abnormal_muscle_cell1.08997152
107MP0003300_gastrointestinal_ulcer1.07674154
108MP0005084_abnormal_gallbladder_morpholo1.07195945
109MP0002229_neurodegeneration1.07188877
110MP0008872_abnormal_physiological_respon1.06421489
111MP0000955_abnormal_spinal_cord1.05895768
112MP0001188_hyperpigmentation1.03044133
113MP0008058_abnormal_DNA_repair1.02854398
114MP0002127_abnormal_cardiovascular_syste1.02488273
115MP0002882_abnormal_neuron_morphology1.02382594
116MP0004085_abnormal_heartbeat1.01345262
117MP0002184_abnormal_innervation1.00735205
118MP0002653_abnormal_ependyma_morphology1.00686689
119MP0002234_abnormal_pharynx_morphology0.99882986
120MP0002163_abnormal_gland_morphology0.98201739
121MP0001984_abnormal_olfaction0.98050892
122MP0000230_abnormal_systemic_arterial0.97871652
123MP0001145_abnormal_male_reproductive0.97257844
124MP0000653_abnormal_sex_gland0.97255670
125MP0003890_abnormal_embryonic-extraembry0.97197203
126MP0008995_early_reproductive_senescence0.94281695
127MP0010678_abnormal_skin_adnexa0.94192980
128MP0003122_maternal_imprinting0.94070329
129MP0006292_abnormal_olfactory_placode0.93520079
130MP0002106_abnormal_muscle_physiology0.93101934
131MP0000747_muscle_weakness0.91121194
132MP0003705_abnormal_hypodermis_morpholog0.90866908
133MP0001764_abnormal_homeostasis0.90786845
134MP0001666_abnormal_nutrient_absorption0.88682225
135MP0005584_abnormal_enzyme/coenzyme_acti0.88471600
136MP0003633_abnormal_nervous_system0.87602125
137MP0003136_yellow_coat_color0.86596555
138MP0001963_abnormal_hearing_physiology0.86328058
139MP0004811_abnormal_neuron_physiology0.85615755
140MP0003283_abnormal_digestive_organ0.84014668
141MP0003937_abnormal_limbs/digits/tail_de0.82991807
142MP0002078_abnormal_glucose_homeostasis0.82855081
143MP0001440_abnormal_grooming_behavior0.82221574
144MP0004742_abnormal_vestibular_system0.79505303
145MP0002152_abnormal_brain_morphology0.78836097
146MP0005375_adipose_tissue_phenotype0.78734876
147MP0002752_abnormal_somatic_nervous0.77799401
148MP0000647_abnormal_sebaceous_gland0.77728064
149MP0002066_abnormal_motor_capabilities/c0.77444485
150MP0001944_abnormal_pancreas_morphology0.76860388
151MP0005389_reproductive_system_phenotype0.76426076
152MP0005083_abnormal_biliary_tract0.76093925
153MP0002736_abnormal_nociception_after0.74579437
154MP0010030_abnormal_orbit_morphology0.74341902
155MP0002909_abnormal_adrenal_gland0.74039275
156MP0003879_abnormal_hair_cell0.73654587
157MP0003567_abnormal_fetal_cardiomyocyte0.73096739
158MP0000759_abnormal_skeletal_muscle0.71629933
159MP0005551_abnormal_eye_electrophysiolog0.71318415
160MP0000013_abnormal_adipose_tissue0.70693705
161MP0005369_muscle_phenotype0.70282419
162MP0005220_abnormal_exocrine_pancreas0.69911576
163MP0010386_abnormal_urinary_bladder0.69533595
164MP0000537_abnormal_urethra_morphology0.68653414
165MP0002118_abnormal_lipid_homeostasis0.68586833
166MP0003119_abnormal_digestive_system0.68336077
167MP0010329_abnormal_lipoprotein_level0.67704754
168MP0005187_abnormal_penis_morphology0.67349537
169MP0005266_abnormal_metabolism0.67217398
170MP0005451_abnormal_body_composition0.66935978
171MP0003984_embryonic_growth_retardation0.65472774
172MP0003186_abnormal_redox_activity0.64950539
173MP0005535_abnormal_body_temperature0.64233818
174MP0002168_other_aberrant_phenotype0.63741183
175MP0005395_other_phenotype0.63658010
176MP0002088_abnormal_embryonic_growth/wei0.62353035
177MP0000678_abnormal_parathyroid_gland0.61269811
178MP0003718_maternal_effect0.61079485
179MP0000538_abnormal_urinary_bladder0.60874760
180MP0003329_amyloid_beta_deposits0.60381369
181MP0000266_abnormal_heart_morphology0.60144877
182MP0002332_abnormal_exercise_endurance0.59138027

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.74719950
2Hyperactive renin-angiotensin system (HP:0000841)4.85240575
3Hyperglycinuria (HP:0003108)4.81620694
4Polyuria (HP:0000103)4.67491814
5Increased circulating renin level (HP:0000848)4.65059926
6Metabolic alkalosis (HP:0200114)4.64932789
7Proximal tubulopathy (HP:0000114)4.41510408
8Abnormal urine output (HP:0012590)4.40847740
9Hypokalemic alkalosis (HP:0001949)4.33514003
10Abnormality of chloride homeostasis (HP:0011422)4.30806678
11Increased purine levels (HP:0004368)4.29526647
12Hyperuricemia (HP:0002149)4.29526647
13Ketoacidosis (HP:0001993)4.28482287
14Abnormality of renal excretion (HP:0011036)4.26264302
15Abnormality of serine family amino acid metabolism (HP:0010894)4.17119247
16Abnormality of glycine metabolism (HP:0010895)4.17119247
17Hyperglycinemia (HP:0002154)3.93466446
18Hyperventilation (HP:0002883)3.81176894
19Abnormal drinking behavior (HP:0030082)3.80335646
20Polydipsia (HP:0001959)3.80335646
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80283503
22Hypomagnesemia (HP:0002917)3.78327931
23Ketosis (HP:0001946)3.77202160
24Sudden death (HP:0001699)3.70594714
25Abnormality of purine metabolism (HP:0004352)3.67047972
26Abnormality of fatty-acid metabolism (HP:0004359)3.55803206
27Nephronophthisis (HP:0000090)3.47517810
28Generalized aminoaciduria (HP:0002909)3.46155752
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.32238498
30Dicarboxylic aciduria (HP:0003215)3.32238498
31Abnormality of magnesium homeostasis (HP:0004921)3.29746425
32Pancreatic cysts (HP:0001737)3.24191427
33Alkalosis (HP:0001948)3.21981222
34Abnormality of renin-angiotensin system (HP:0000847)3.17448029
35Hypoglycemic coma (HP:0001325)3.13828527
36Hyperaldosteronism (HP:0000859)3.13162290
37Myoglobinuria (HP:0002913)3.10206411
38Abnormality of the renal medulla (HP:0100957)3.08539645
39Glycosuria (HP:0003076)3.06973454
40Abnormality of urine glucose concentration (HP:0011016)3.06973454
41Pancreatic fibrosis (HP:0100732)3.06606705
42Hyperammonemia (HP:0001987)3.06082974
43True hermaphroditism (HP:0010459)3.02222892
44Progressive cerebellar ataxia (HP:0002073)3.01209563
45Renal salt wasting (HP:0000127)2.99986921
46Medial flaring of the eyebrow (HP:0010747)2.94197606
47Chronic hepatic failure (HP:0100626)2.88549325
48Abnormality of midbrain morphology (HP:0002418)2.86931059
49Molar tooth sign on MRI (HP:0002419)2.86931059
50Tetany (HP:0001281)2.80747291
51Gaze-evoked nystagmus (HP:0000640)2.80659138
52Abnormality of nucleobase metabolism (HP:0010932)2.80443512
53Hypercalciuria (HP:0002150)2.79910482
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77815987
55Abnormality of alanine metabolism (HP:0010916)2.77815987
56Hyperalaninemia (HP:0003348)2.77815987
57Syncope (HP:0001279)2.76030337
58Gait imbalance (HP:0002141)2.74162250
59Absent speech (HP:0001344)2.72697846
60Hydroxyprolinuria (HP:0003080)2.72099100
61Abnormality of proline metabolism (HP:0010907)2.72099100
62Palpitations (HP:0001962)2.71851762
63Right ventricular cardiomyopathy (HP:0011663)2.71798128
64Tubulointerstitial nephritis (HP:0001970)2.67742395
65Lethargy (HP:0001254)2.63486426
66Febrile seizures (HP:0002373)2.61919982
67Muscle fiber splitting (HP:0003555)2.59971818
68Ventricular fibrillation (HP:0001663)2.58839245
69Methylmalonic aciduria (HP:0012120)2.58509050
70Intestinal atresia (HP:0011100)2.57992247
71Abnormality of serum amino acid levels (HP:0003112)2.57464736
72Type II lissencephaly (HP:0007260)2.56572674
73Congenital primary aphakia (HP:0007707)2.55866607
74Genetic anticipation (HP:0003743)2.53707825
75Nephrogenic diabetes insipidus (HP:0009806)2.52530879
76Ventricular tachycardia (HP:0004756)2.52188292
77Hyperphosphaturia (HP:0003109)2.47021726
78Hypokalemia (HP:0002900)2.45624538
79Metabolic acidosis (HP:0001942)2.44051260
80Epileptic encephalopathy (HP:0200134)2.42970492
81Hemiparesis (HP:0001269)2.41946294
82Broad-based gait (HP:0002136)2.39658327
83Drooling (HP:0002307)2.39641500
84Hepatic necrosis (HP:0002605)2.39462505
85Volvulus (HP:0002580)2.39249923
86Rhabdomyolysis (HP:0003201)2.38022860
87Genital tract atresia (HP:0001827)2.37820404
88Abnormality of the renal cortex (HP:0011035)2.37779109
89Cerebral edema (HP:0002181)2.36430508
90Acute encephalopathy (HP:0006846)2.35882827
91Bundle branch block (HP:0011710)2.34450163
92Exercise-induced muscle cramps (HP:0003710)2.34167473
93Exercise-induced myalgia (HP:0003738)2.31095494
94Congenital stationary night blindness (HP:0007642)2.28770449
95Vaginal atresia (HP:0000148)2.26419950
96Vomiting (HP:0002013)2.25005521
97Lissencephaly (HP:0001339)2.24654670
98Bony spicule pigmentary retinopathy (HP:0007737)2.24563381
99Oligodactyly (hands) (HP:0001180)2.22344475
100Abnormality of the labia minora (HP:0012880)2.18460818
101Abnormal urine phosphate concentration (HP:0012599)2.18410962
102Atrial fibrillation (HP:0005110)2.17691610
103Calf muscle hypertrophy (HP:0008981)2.15888181
104Ragged-red muscle fibers (HP:0003200)2.15413269
105Late onset (HP:0003584)2.15395015
106Epileptiform EEG discharges (HP:0011182)2.15066945
107Abnormality of the calf musculature (HP:0001430)2.14002154
108EEG with generalized epileptiform discharges (HP:0011198)2.13319232
109Attenuation of retinal blood vessels (HP:0007843)2.13259061
110Optic nerve hypoplasia (HP:0000609)2.13161558
111Delayed CNS myelination (HP:0002188)2.12733334
112Abnormality of potassium homeostasis (HP:0011042)2.12584963
113Malnutrition (HP:0004395)2.12134746
114Cystic liver disease (HP:0006706)2.12028876
115Tubular atrophy (HP:0000092)2.11967419
116Abnormal mitochondria in muscle tissue (HP:0008316)2.11586916
117Hypsarrhythmia (HP:0002521)2.10769546
118Excessive salivation (HP:0003781)2.10463833
119Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07795272
120Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07701801
121Ventricular arrhythmia (HP:0004308)2.06058655
122Abnormality of macular pigmentation (HP:0008002)2.03852933
123Primary atrial arrhythmia (HP:0001692)2.03466418
124Focal seizures (HP:0007359)2.01218486
125Focal motor seizures (HP:0011153)2.01048119
126Nephrolithiasis (HP:0000787)2.00873458
127Central scotoma (HP:0000603)2.00147423
128Poor coordination (HP:0002370)1.99099945
129Increased muscle lipid content (HP:0009058)1.97633047
130Myokymia (HP:0002411)1.97545373
131Abnormal respiratory epithelium morphology (HP:0012253)1.97109980
132Abnormal respiratory motile cilium morphology (HP:0005938)1.97109980
133Nephrocalcinosis (HP:0000121)1.95910260
134Lactic acidosis (HP:0003128)1.95843973
135Prolonged QT interval (HP:0001657)1.95543409
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94064074
137Supraventricular tachycardia (HP:0004755)1.93898220
138Cerebellar dysplasia (HP:0007033)1.93837488
139Supraventricular arrhythmia (HP:0005115)1.93267822
140Abnormal ciliary motility (HP:0012262)1.92854506
141Decreased circulating renin level (HP:0003351)1.92134627
142Hyperinsulinemic hypoglycemia (HP:0000825)1.89987447
143Lipoatrophy (HP:0100578)1.89238839
144Inability to walk (HP:0002540)1.88495004
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87086648
146Lymphangioma (HP:0100764)1.86702839
147Dilated cardiomyopathy (HP:0001644)1.86412342
148Renal tubular acidosis (HP:0001947)1.86333320
149Dialeptic seizures (HP:0011146)1.86234873
150Absent/shortened dynein arms (HP:0200106)1.86095913
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.86095913
152Degeneration of the lateral corticospinal tracts (HP:0002314)1.85300426
153Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85300426
154Occipital encephalocele (HP:0002085)1.84955687
155Athetosis (HP:0002305)1.84729522
156Acute necrotizing encephalopathy (HP:0006965)1.83856395
157Chronic bronchitis (HP:0004469)1.83853449
158Retinal dysplasia (HP:0007973)1.83541616
159Nausea (HP:0002018)1.82414100
160Specific learning disability (HP:0001328)1.82347956
161Hepatocellular necrosis (HP:0001404)1.81932117
162Protruding tongue (HP:0010808)1.81567867
163Neoplasm of the adrenal cortex (HP:0100641)1.80712495
164Abnormality of cochlea (HP:0000375)1.80479834
165Postaxial foot polydactyly (HP:0001830)1.79142780
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.75727771
167Abnormality of the corticospinal tract (HP:0002492)1.73224532
168Atonic seizures (HP:0010819)1.73007485
169Gastrointestinal atresia (HP:0002589)1.72429539
170Abnormal respiratory motile cilium physiology (HP:0012261)1.71961256
171Progressive inability to walk (HP:0002505)1.71734261
172Abnormal rod and cone electroretinograms (HP:0008323)1.71158587
173Sclerocornea (HP:0000647)1.68393840
174Fair hair (HP:0002286)1.66079933
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.65426741
176Widely spaced teeth (HP:0000687)1.64015351
177Urinary bladder sphincter dysfunction (HP:0002839)1.63880122
178Agitation (HP:0000713)1.62925612
179Tubulointerstitial abnormality (HP:0001969)1.62844621
180Congenital hepatic fibrosis (HP:0002612)1.62634166
181Absence seizures (HP:0002121)1.62126422
182Male pseudohermaphroditism (HP:0000037)1.61972710
183Dyskinesia (HP:0100660)1.61472787
184Pachygyria (HP:0001302)1.59876839
185Amyotrophic lateral sclerosis (HP:0007354)1.59252524
186Congenital malformation of the right heart (HP:0011723)1.58961614
187Double outlet right ventricle (HP:0001719)1.58961614
188Postaxial hand polydactyly (HP:0001162)1.58737068

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.01972910
2WNK34.78151712
3PDK44.45355989
4PDK34.45355989
5NEK14.07782071
6CASK3.94483426
7BCKDK3.48236866
8MAP4K22.76066507
9PRKD32.70749980
10PDK22.65712204
11OXSR12.56948316
12MARK12.32258356
13BMPR1B2.24192328
14ACVR1B2.21204413
15NTRK32.04771145
16PKN21.98101312
17EPHA21.95711521
18LMTK21.92304586
19MAPK131.86422181
20TRIM281.83617241
21STK391.81057182
22PINK11.81036103
23MYLK1.79786086
24AKT31.75859191
25TRIB31.73015523
26PIK3CA1.72767335
27FGFR21.71697604
28PLK21.71430915
29TNIK1.68465048
30TTN1.65778563
31DAPK21.63699946
32DMPK1.62513192
33TESK11.57518973
34PAK31.48187020
35GRK11.46925168
36MKNK21.45224596
37MAP3K71.43110093
38NME11.42884615
39MAP2K71.40293320
40PHKG21.38675707
41PHKG11.38675707
42BCR1.33440820
43CSNK1G21.32014686
44PLK41.28592409
45LATS21.25136734
46NTRK21.14735910
47SGK21.14081227
48CSNK1G11.10423760
49CSNK1G31.07550372
50FER1.06300415
51PRKCE1.06006979
52PRKCG1.05589233
53CAMK1G1.05243669
54MAP3K41.04975892
55* STK381.03387314
56NUAK11.02862869
57BRD40.98603486
58TTK0.98356690
59BRSK20.98189830
60CSNK1A1L0.97419198
61ADRBK20.94807281
62PRKAA10.89627409
63ERBB30.88362999
64WNK10.87309588
65DYRK1B0.85576156
66LATS10.85196965
67MST40.84789508
68UHMK10.84466739
69MAP3K110.83953190
70ILK0.81608131
71PBK0.80522312
72CDK190.80037699
73MINK10.78594664
74NEK20.76911770
75SCYL20.75104210
76PTK2B0.73425940
77DYRK1A0.73181823
78CAMK2A0.72906923
79ZAK0.72869610
80* STK38L0.71966105
81OBSCN0.71335225
82CDC42BPA0.70251543
83PNCK0.70081051
84MAP2K40.69707893
85PRKD20.69468797
86FGFR40.68802908
87TNK20.67493494
88NEK60.67166227
89PAK40.65389669
90EIF2AK10.65174156
91DYRK20.64690476
92STK30.64435462
93TAOK30.63330060
94STK110.59941301
95PAK60.59634067
96CSNK1D0.58536043
97RIPK10.58223258
98CAMK10.57213716
99MAPKAPK30.56620516
100CDK50.56125374
101SGK10.55213575
102TAOK10.55061578
103PTK60.55051453
104MAP3K30.54449396
105PRKCI0.54069190
106INSRR0.51563750
107EPHB20.50700088
108MAP3K50.49947243
109CDK30.49741399
110PDPK10.49026217
111ATM0.48311453
112ICK0.48257749
113PTK20.48194012
114DAPK30.47076204
115PRKG10.46302066
116EPHA40.45851706
117PRKCZ0.45797460
118PRKACA0.44623062
119CSNK1A10.44566560
120CAMK40.44444473
121PLK30.44427711
122SGK30.44382812
123CDK40.43541144
124MKNK10.42617420
125TAOK20.42414551
126ROCK10.41978913
127SGK4940.40860716
128SGK2230.40860716
129ERBB20.40386135
130NLK0.40257069
131CAMK2D0.40231041
132WEE10.40046116
133MAP3K100.38793652
134PDK10.38743698
135STK240.38672375
136CHEK20.38523382
137EIF2AK30.38420804
138PKN10.38236755
139BUB10.37123430
140MAPK110.37110093
141KSR10.37098914
142VRK10.36640550
143FRK0.36390536
144TLK10.36364356
145RPS6KA30.36314075
146GRK60.36202261
147CAMKK20.36110075
148CDC70.35775970
149CAMK2B0.35040494
150GSK3B0.34925061
151MTOR0.34198762
152MAP2K10.33931067
153FLT30.33587627
154ADRBK10.33290936
155AURKA0.33272826
156PRKACB0.32604242
157AKT20.32523374
158PLK10.31718605
159RAF10.27726702
160CSNK1E0.27547642
161NEK90.27200078
162MARK30.26708280
163PRKD10.26413177
164NME20.26384546
165AURKB0.25838385
166PRKAA20.23349093

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.19048536
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.66965840
3Propanoate metabolism_Homo sapiens_hsa006403.29977800
4Nicotine addiction_Homo sapiens_hsa050333.20013008
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.17510730
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09805611
7Pyruvate metabolism_Homo sapiens_hsa006203.07975863
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.81580013
9Fatty acid degradation_Homo sapiens_hsa000712.79223744
10Butanoate metabolism_Homo sapiens_hsa006502.79125550
11Carbon metabolism_Homo sapiens_hsa012002.71827361
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.38333581
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.34560283
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27583303
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20766592
16Phototransduction_Homo sapiens_hsa047442.10254032
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.02958555
18GABAergic synapse_Homo sapiens_hsa047271.98827926
19Cardiac muscle contraction_Homo sapiens_hsa042601.96038866
20Taste transduction_Homo sapiens_hsa047421.84494044
21Tryptophan metabolism_Homo sapiens_hsa003801.82582750
22Oxidative phosphorylation_Homo sapiens_hsa001901.82325041
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81620500
24Biosynthesis of amino acids_Homo sapiens_hsa012301.80383066
25Fatty acid metabolism_Homo sapiens_hsa012121.76898819
26Circadian entrainment_Homo sapiens_hsa047131.74438747
27Glutamatergic synapse_Homo sapiens_hsa047241.73566903
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72620762
29Morphine addiction_Homo sapiens_hsa050321.70140526
30Arginine biosynthesis_Homo sapiens_hsa002201.67310361
31Peroxisome_Homo sapiens_hsa041461.64161523
32Parkinsons disease_Homo sapiens_hsa050121.64023853
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61984371
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61530472
35Olfactory transduction_Homo sapiens_hsa047401.49219240
36Fanconi anemia pathway_Homo sapiens_hsa034601.46828807
37Protein export_Homo sapiens_hsa030601.46591450
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42647599
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41756211
40Amphetamine addiction_Homo sapiens_hsa050311.38386203
41Linoleic acid metabolism_Homo sapiens_hsa005911.33750153
42Fatty acid biosynthesis_Homo sapiens_hsa000611.32259546
43Dopaminergic synapse_Homo sapiens_hsa047281.31129681
44Sulfur metabolism_Homo sapiens_hsa009201.28825350
45beta-Alanine metabolism_Homo sapiens_hsa004101.28821313
46Regulation of autophagy_Homo sapiens_hsa041401.26230816
47ABC transporters_Homo sapiens_hsa020101.25093920
48Selenocompound metabolism_Homo sapiens_hsa004501.24836736
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.22530833
50Bile secretion_Homo sapiens_hsa049761.22220408
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22029685
52Arginine and proline metabolism_Homo sapiens_hsa003301.20680726
53Fructose and mannose metabolism_Homo sapiens_hsa000511.19227633
54Huntingtons disease_Homo sapiens_hsa050161.18547001
55Salivary secretion_Homo sapiens_hsa049701.12163662
56Serotonergic synapse_Homo sapiens_hsa047261.10944352
57Basal transcription factors_Homo sapiens_hsa030221.10464712
58Long-term depression_Homo sapiens_hsa047301.09509224
59Collecting duct acid secretion_Homo sapiens_hsa049661.08351001
60Ether lipid metabolism_Homo sapiens_hsa005651.07632483
61Caffeine metabolism_Homo sapiens_hsa002321.07325781
62PPAR signaling pathway_Homo sapiens_hsa033201.06907438
63Alzheimers disease_Homo sapiens_hsa050101.05834901
64Lysine degradation_Homo sapiens_hsa003101.03837958
65Starch and sucrose metabolism_Homo sapiens_hsa005001.03643421
66Glutathione metabolism_Homo sapiens_hsa004801.01824495
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97767836
68Vitamin digestion and absorption_Homo sapiens_hsa049770.94411824
69Homologous recombination_Homo sapiens_hsa034400.94139185
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93697089
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93513040
72Glucagon signaling pathway_Homo sapiens_hsa049220.92793866
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91057061
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.89643590
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.89632871
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89372326
77Non-homologous end-joining_Homo sapiens_hsa034500.87476671
78Dilated cardiomyopathy_Homo sapiens_hsa054140.87011637
79Oocyte meiosis_Homo sapiens_hsa041140.86579015
80cAMP signaling pathway_Homo sapiens_hsa040240.85846029
81Calcium signaling pathway_Homo sapiens_hsa040200.83742043
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83675199
83Pancreatic secretion_Homo sapiens_hsa049720.83223162
84Nitrogen metabolism_Homo sapiens_hsa009100.82193609
85Cocaine addiction_Homo sapiens_hsa050300.82177103
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.81479552
87Dorso-ventral axis formation_Homo sapiens_hsa043200.80342725
88Pentose phosphate pathway_Homo sapiens_hsa000300.79217087
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78693572
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78039685
91Type II diabetes mellitus_Homo sapiens_hsa049300.77022794
92Phenylalanine metabolism_Homo sapiens_hsa003600.75425910
93Glycerolipid metabolism_Homo sapiens_hsa005610.73541194
94Mineral absorption_Homo sapiens_hsa049780.69650356
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67000871
96Folate biosynthesis_Homo sapiens_hsa007900.65938238
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64565203
98Cholinergic synapse_Homo sapiens_hsa047250.64544504
99Hedgehog signaling pathway_Homo sapiens_hsa043400.64287916
100RNA degradation_Homo sapiens_hsa030180.63483106
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.63089359
102Galactose metabolism_Homo sapiens_hsa000520.60857650
103Metabolic pathways_Homo sapiens_hsa011000.59472139
104Sphingolipid metabolism_Homo sapiens_hsa006000.59350093
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55835234
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54771768
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54631248
108Tight junction_Homo sapiens_hsa045300.54620926
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54495045
110Tyrosine metabolism_Homo sapiens_hsa003500.53704189
111Sulfur relay system_Homo sapiens_hsa041220.50666971
112Oxytocin signaling pathway_Homo sapiens_hsa049210.49497014
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49362620
114Insulin secretion_Homo sapiens_hsa049110.49001436
115Long-term potentiation_Homo sapiens_hsa047200.48334530
116AMPK signaling pathway_Homo sapiens_hsa041520.46653895
117Fat digestion and absorption_Homo sapiens_hsa049750.45656098
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45107333
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45059699
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45039091
121Chemical carcinogenesis_Homo sapiens_hsa052040.42974360
122Ovarian steroidogenesis_Homo sapiens_hsa049130.42712715
123Hippo signaling pathway_Homo sapiens_hsa043900.41408308
124Retinol metabolism_Homo sapiens_hsa008300.41314989
125Synaptic vesicle cycle_Homo sapiens_hsa047210.41292303
126Protein digestion and absorption_Homo sapiens_hsa049740.39510252
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39353204
128Circadian rhythm_Homo sapiens_hsa047100.36578452
129Thyroid hormone synthesis_Homo sapiens_hsa049180.35644954
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33665259
131Gastric acid secretion_Homo sapiens_hsa049710.32930957
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30696583
133Insulin resistance_Homo sapiens_hsa049310.30340036
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.28804695
135Insulin signaling pathway_Homo sapiens_hsa049100.27333800
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24575394
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24256904
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22768179
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22564696
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21462573
141Adherens junction_Homo sapiens_hsa045200.21461697
142Renin secretion_Homo sapiens_hsa049240.19089770
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.18659375
144Fatty acid elongation_Homo sapiens_hsa000620.18655257
145One carbon pool by folate_Homo sapiens_hsa006700.18028901
146Bladder cancer_Homo sapiens_hsa052190.16284934
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16023071
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15960056
149Histidine metabolism_Homo sapiens_hsa003400.15183485
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13811579

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