RAB40AL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. Disruptions in this gene are associated with Duchenne muscular dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translesion synthesis (GO:0019985)6.31131860
2DNA strand renaturation (GO:0000733)6.09176486
3retinal cone cell development (GO:0046549)5.90747240
4heparan sulfate proteoglycan biosynthetic process (GO:0015012)5.86097620
5replication fork processing (GO:0031297)5.32298137
6lateral sprouting from an epithelium (GO:0060601)5.15148987
7transcription from mitochondrial promoter (GO:0006390)4.95875894
8cellular response to interleukin-15 (GO:0071350)4.77657959
9negative regulation of DNA repair (GO:0045738)4.55325107
10cell wall macromolecule catabolic process (GO:0016998)4.51803607
11peptidyl-histidine modification (GO:0018202)4.48068469
12interferon-gamma secretion (GO:0072643)4.47275929
13proteasome assembly (GO:0043248)4.47113956
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.41386007
15negative regulation of translation, ncRNA-mediated (GO:0040033)4.41386007
16regulation of translation, ncRNA-mediated (GO:0045974)4.41386007
17tongue development (GO:0043586)4.23131456
18positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)4.22309245
19positive regulation of cell cycle G2/M phase transition (GO:1902751)4.22309245
20synapsis (GO:0007129)4.17455559
21cilium or flagellum-dependent cell motility (GO:0001539)4.12027708
22protein heterotetramerization (GO:0051290)4.10448842
23intraciliary transport (GO:0042073)4.07548787
24epithelial cilium movement (GO:0003351)3.98802083
25postreplication repair (GO:0006301)3.98483539
26negative regulation of DNA recombination (GO:0045910)3.97562126
27reciprocal meiotic recombination (GO:0007131)3.95131845
28reciprocal DNA recombination (GO:0035825)3.95131845
29cell wall macromolecule metabolic process (GO:0044036)3.94399837
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86271056
31iron-sulfur cluster assembly (GO:0016226)3.85344626
32metallo-sulfur cluster assembly (GO:0031163)3.85344626
33DNA replication-dependent nucleosome organization (GO:0034723)3.84747624
34DNA replication-dependent nucleosome assembly (GO:0006335)3.84747624
35heparan sulfate proteoglycan metabolic process (GO:0030201)3.80505804
36ubiquinone biosynthetic process (GO:0006744)3.68950426
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.64005667
38lens development in camera-type eye (GO:0002088)3.62058443
39maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.61060566
40resolution of meiotic recombination intermediates (GO:0000712)3.59032323
41DNA replication initiation (GO:0006270)3.58696221
42DNA strand elongation involved in DNA replication (GO:0006271)3.57925954
43histone H2A acetylation (GO:0043968)3.53723725
44chromatin remodeling at centromere (GO:0031055)3.50631719
45ubiquinone metabolic process (GO:0006743)3.48575952
46blood vessel maturation (GO:0001955)3.43985721
47histone exchange (GO:0043486)3.40499258
48artery development (GO:0060840)3.35966066
49glycerophospholipid catabolic process (GO:0046475)3.35070987
50serine family amino acid catabolic process (GO:0009071)3.34723797
51DNA strand elongation (GO:0022616)3.34361934
52DNA integration (GO:0015074)3.29412961
53negative regulation of smooth muscle cell differentiation (GO:0051151)3.29101856
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.26141778
55NADH dehydrogenase complex assembly (GO:0010257)3.26141778
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26141778
57CENP-A containing nucleosome assembly (GO:0034080)3.25118020
58cilium movement (GO:0003341)3.21636314
59motile cilium assembly (GO:0044458)3.19657284
60dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.17184338
61chromosome organization involved in meiosis (GO:0070192)3.17003129
62response to interleukin-15 (GO:0070672)3.16626877
63quinone biosynthetic process (GO:1901663)3.14871932
64ribosome assembly (GO:0042255)3.11150411
65regulation of protein polyubiquitination (GO:1902914)3.10813196
66viral mRNA export from host cell nucleus (GO:0046784)3.08408596
67protein K6-linked ubiquitination (GO:0085020)3.07971217
68telomere maintenance via semi-conservative replication (GO:0032201)3.04862142
69proteoglycan biosynthetic process (GO:0030166)3.03487636
70DNA double-strand break processing (GO:0000729)3.00486493
71C4-dicarboxylate transport (GO:0015740)2.99091261
72DNA biosynthetic process (GO:0071897)2.98590548
73GTP biosynthetic process (GO:0006183)2.93317440
74male sex determination (GO:0030238)2.92871936
75pre-miRNA processing (GO:0031054)2.92706374
76lipid particle organization (GO:0034389)2.90507941
77recombinational repair (GO:0000725)2.88136068
78double-strand break repair via homologous recombination (GO:0000724)2.88049268
79DNA synthesis involved in DNA repair (GO:0000731)2.87521898
80somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87148459
81somatic hypermutation of immunoglobulin genes (GO:0016446)2.87148459
82kidney morphogenesis (GO:0060993)2.86023763
83mitochondrial respiratory chain complex assembly (GO:0033108)2.84714789
84mitochondrial RNA metabolic process (GO:0000959)2.83489290
85negative regulation of axon guidance (GO:1902668)2.82832354
86positive regulation of catenin import into nucleus (GO:0035413)2.81159489
87protein sumoylation (GO:0016925)2.77906748
88protein complex biogenesis (GO:0070271)2.77431611
89regulation of DNA endoreduplication (GO:0032875)2.75339385
90guanosine-containing compound biosynthetic process (GO:1901070)2.74041215
91telomere maintenance via recombination (GO:0000722)2.72523332
92DNA replication-independent nucleosome organization (GO:0034724)2.70747167
93DNA replication-independent nucleosome assembly (GO:0006336)2.70747167
94inner ear receptor stereocilium organization (GO:0060122)2.70182226
95double-strand break repair (GO:0006302)2.69648687
96regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.69109809
97regulation of double-strand break repair (GO:2000779)2.67005190
98termination of RNA polymerase II transcription (GO:0006369)2.66825020
99heparin biosynthetic process (GO:0030210)11.0249827
100heparin metabolic process (GO:0030202)11.0249827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.44214003
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.73434375
3RBPJ_22232070_ChIP-Seq_NCS_Mouse5.80157514
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.86492163
5IGF1R_20145208_ChIP-Seq_DFB_Human3.80891585
6EZH2_22144423_ChIP-Seq_EOC_Human3.80065468
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59407303
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52080125
9GBX2_23144817_ChIP-Seq_PC3_Human2.35340246
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33916096
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.22354392
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17280694
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.13480787
14ZNF274_21170338_ChIP-Seq_K562_Hela2.03174344
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95648129
16AR_21572438_ChIP-Seq_LNCaP_Human1.92307722
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.90372779
18P300_19829295_ChIP-Seq_ESCs_Human1.88616171
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88045272
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.81161425
21EWS_26573619_Chip-Seq_HEK293_Human1.79336102
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.79130706
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76395033
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70692619
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68236349
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.67819367
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.67132252
28FUS_26573619_Chip-Seq_HEK293_Human1.63507644
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62591149
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61937367
31ELK1_19687146_ChIP-ChIP_HELA_Human1.61187600
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60831630
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54337175
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51913680
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49783517
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43595348
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41879663
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38827141
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.36257030
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35541990
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.35079327
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30587385
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.29799349
44MYC_18940864_ChIP-ChIP_HL60_Human1.27224470
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.25544994
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23920261
47BCAT_22108803_ChIP-Seq_LS180_Human1.19703865
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17033186
49AR_25329375_ChIP-Seq_VCAP_Human1.14951423
50ER_23166858_ChIP-Seq_MCF-7_Human1.14003867
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.13731536
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12502091
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11471601
54TTF2_22483619_ChIP-Seq_HELA_Human1.11401029
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11165159
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10959621
57VDR_23849224_ChIP-Seq_CD4+_Human1.10183576
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08321533
59VDR_22108803_ChIP-Seq_LS180_Human1.06787840
60FOXP3_21729870_ChIP-Seq_TREG_Human1.06458039
61DCP1A_22483619_ChIP-Seq_HELA_Human1.05324771
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04478715
63SMAD4_21799915_ChIP-Seq_A2780_Human1.04327807
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04003289
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03073178
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02531742
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01679736
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01484730
69TCF4_23295773_ChIP-Seq_U87_Human1.00864848
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00002723
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.00002723
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98275554
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97756525
74ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91719977
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90958377
76RNF2_27304074_Chip-Seq_NSC_Mouse0.90904118
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90282913
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90091895
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89707735
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89074459
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88254681
82ERG_20517297_ChIP-Seq_VCAP_Human0.87364894
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86030265
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84997796
85RUNX2_22187159_ChIP-Seq_PCA_Human0.83753362
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82433858
87CBP_20019798_ChIP-Seq_JUKART_Human0.82356318
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82356318
89NANOG_19829295_ChIP-Seq_ESCs_Human0.81454358
90SOX2_19829295_ChIP-Seq_ESCs_Human0.81454358
91* STAT3_23295773_ChIP-Seq_U87_Human0.81369614
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.81236040
93CBP_21632823_ChIP-Seq_H3396_Human0.80192520
94JUN_21703547_ChIP-Seq_K562_Human0.80029636
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79534307
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79300268
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79210039
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79196476
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77775849
100TP53_22573176_ChIP-Seq_HFKS_Human0.77341780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.41866896
2MP0009697_abnormal_copulation4.94204517
3MP0006292_abnormal_olfactory_placode3.54052294
4MP0010094_abnormal_chromosome_stability3.42516854
5MP0010030_abnormal_orbit_morphology3.23562729
6MP0008877_abnormal_DNA_methylation2.79936167
7MP0002938_white_spotting2.71672172
8MP0001529_abnormal_vocalization2.66920442
9MP0003283_abnormal_digestive_organ2.47217029
10MP0002163_abnormal_gland_morphology2.40986642
11MP0001346_abnormal_lacrimal_gland2.40046747
12MP0003938_abnormal_ear_development2.37903952
13MP0008058_abnormal_DNA_repair2.25770564
14MP0006036_abnormal_mitochondrial_physio2.21527129
15MP0003111_abnormal_nucleus_morphology2.16044643
16MP0002102_abnormal_ear_morphology2.10792098
17MP0002332_abnormal_exercise_endurance2.06063550
18MP0000579_abnormal_nail_morphology1.84067636
19MP0002697_abnormal_eye_size1.74494227
20MP0001293_anophthalmia1.73451446
21MP0008057_abnormal_DNA_replication1.68507042
22MP0005248_abnormal_Harderian_gland1.68004330
23MP0003385_abnormal_body_wall1.58896097
24MP0002234_abnormal_pharynx_morphology1.56381961
25MP0006072_abnormal_retinal_apoptosis1.52802274
26MP0008789_abnormal_olfactory_epithelium1.50651034
27MP0001929_abnormal_gametogenesis1.49800259
28MP0008875_abnormal_xenobiotic_pharmacok1.48415336
29MP0002160_abnormal_reproductive_system1.46842366
30MP0005266_abnormal_metabolism1.43147339
31MP0009053_abnormal_anal_canal1.42422064
32MP0002210_abnormal_sex_determination1.39783147
33MP0005499_abnormal_olfactory_system1.38377638
34MP0005394_taste/olfaction_phenotype1.38377638
35MP0003077_abnormal_cell_cycle1.36798534
36MP0000749_muscle_degeneration1.33075492
37MP0002282_abnormal_trachea_morphology1.32196923
38MP0000653_abnormal_sex_gland1.28564938
39MP0003718_maternal_effect1.28217836
40MP0003315_abnormal_perineum_morphology1.26563837
41MP0002233_abnormal_nose_morphology1.21349196
42MP0001145_abnormal_male_reproductive1.21295588
43MP0003937_abnormal_limbs/digits/tail_de1.19313660
44MP0003698_abnormal_male_reproductive1.14443788
45MP0005551_abnormal_eye_electrophysiolog1.13811848
46MP0001485_abnormal_pinna_reflex1.13671938
47MP0001119_abnormal_female_reproductive1.11829847
48MP0003786_premature_aging1.10988587
49MP0001299_abnormal_eye_distance/1.07584464
50MP0006035_abnormal_mitochondrial_morpho1.06319469
51MP0006276_abnormal_autonomic_nervous0.98587625
52MP0005365_abnormal_bile_salt0.98227800
53MP0005379_endocrine/exocrine_gland_phen0.97401377
54MP0000026_abnormal_inner_ear0.96624858
55MP0005391_vision/eye_phenotype0.95325846
56MP0005084_abnormal_gallbladder_morpholo0.90709962
57MP0002837_dystrophic_cardiac_calcinosis0.90421044
58MP0004084_abnormal_cardiac_muscle0.90286620
59MP0001486_abnormal_startle_reflex0.90114714
60MP0000049_abnormal_middle_ear0.89617962
61MP0002277_abnormal_respiratory_mucosa0.87551519
62MP0000428_abnormal_craniofacial_morphol0.86865885
63MP0009046_muscle_twitch0.86719337
64MP0005171_absent_coat_pigmentation0.86471814
65MP0002932_abnormal_joint_morphology0.86365656
66MP0004215_abnormal_myocardial_fiber0.85868393
67MP0005253_abnormal_eye_physiology0.85835568
68MP0003136_yellow_coat_color0.85384083
69MP0000569_abnormal_digit_pigmentation0.81699859
70MP0003123_paternal_imprinting0.81521137
71MP0001764_abnormal_homeostasis0.81073524
72MP0002092_abnormal_eye_morphology0.79859429
73MP0000631_abnormal_neuroendocrine_gland0.76933461
74MP0002876_abnormal_thyroid_physiology0.76006399
75MP0002111_abnormal_tail_morphology0.75099554
76MP0009250_abnormal_appendicular_skeleto0.74803025
77MP0005195_abnormal_posterior_eye0.74380365
78MP0008007_abnormal_cellular_replicative0.74260599
79MP0003755_abnormal_palate_morphology0.74011617
80MP0002109_abnormal_limb_morphology0.73987749
81MP0002161_abnormal_fertility/fecundity0.72086261
82MP0001944_abnormal_pancreas_morphology0.71291018
83MP0001963_abnormal_hearing_physiology0.70686718
84MP0001286_abnormal_eye_development0.70046774
85MP0002751_abnormal_autonomic_nervous0.69508446
86MP0003936_abnormal_reproductive_system0.69408809
87MP0002249_abnormal_larynx_morphology0.69047055
88MP0005395_other_phenotype0.68521381
89MP0002132_abnormal_respiratory_system0.67707997
90MP0003935_abnormal_craniofacial_develop0.67443317
91MP0003119_abnormal_digestive_system0.66038365
92MP0009384_cardiac_valve_regurgitation0.65197980
93MP0000538_abnormal_urinary_bladder0.64999328
94MP0010368_abnormal_lymphatic_system0.63916314
95MP0002115_abnormal_skeleton_extremities0.63377387
96MP0004145_abnormal_muscle_electrophysio0.63221319
97MP0000358_abnormal_cell_content/0.63159580
98MP0002085_abnormal_embryonic_tissue0.62744305
99MP0004036_abnormal_muscle_relaxation0.62413457
100MP0001697_abnormal_embryo_size0.60625975

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.81965094
2Chromsome breakage (HP:0040012)5.12612143
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.36484268
4Absent/shortened dynein arms (HP:0200106)4.36484268
5Abnormality of the ileum (HP:0001549)4.35072895
6Zonular cataract (HP:0010920)4.22916311
7Aplasia/Hypoplasia of the uvula (HP:0010293)4.15959895
8Meckel diverticulum (HP:0002245)4.14241162
9Abnormality of the preputium (HP:0100587)3.71957447
10True hermaphroditism (HP:0010459)3.56532030
11Pancreatic islet-cell hyperplasia (HP:0004510)3.55421989
12Ectopic kidney (HP:0000086)3.45273907
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.42657652
14Abnormality of chromosome stability (HP:0003220)3.29923940
15Hypoglycemic coma (HP:0001325)3.21547859
16Testicular atrophy (HP:0000029)3.16104921
17Duplicated collecting system (HP:0000081)3.10801270
18Small intestinal stenosis (HP:0012848)3.08366256
19Duodenal stenosis (HP:0100867)3.08366256
20Reticulocytopenia (HP:0001896)3.05866932
21Tubulointerstitial nephritis (HP:0001970)3.02536519
22Abnormal biliary tract physiology (HP:0012439)2.96914511
23Bile duct proliferation (HP:0001408)2.96914511
24Symptomatic seizures (HP:0011145)2.95257650
25Hypoglycemic seizures (HP:0002173)2.95015781
26Abnormal ciliary motility (HP:0012262)2.87699531
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.85670163
28Pancreatic fibrosis (HP:0100732)2.80716455
29Abnormality of lateral ventricle (HP:0030047)2.79505521
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.76154051
31Abnormal rod and cone electroretinograms (HP:0008323)2.75855883
32Triphalangeal thumb (HP:0001199)2.73968374
33Abnormality of the renal collecting system (HP:0004742)2.71520286
34Abnormality of the duodenum (HP:0002246)2.66756471
35Enlarged penis (HP:0000040)2.66203333
36Clubbing of toes (HP:0100760)2.65229682
37Ragged-red muscle fibers (HP:0003200)2.63786681
38Abnormality of the carotid arteries (HP:0005344)2.62372376
39Pancreatic cysts (HP:0001737)2.60871348
40Intestinal atresia (HP:0011100)2.55699010
41Sloping forehead (HP:0000340)2.53035584
42Abnormal respiratory motile cilium morphology (HP:0005938)2.52780492
43Abnormal respiratory epithelium morphology (HP:0012253)2.52780492
44Absent radius (HP:0003974)2.50644194
45Absent thumb (HP:0009777)2.49127056
46Long foot (HP:0001833)2.45965344
47Nephronophthisis (HP:0000090)2.41863095
48Abnormality of midbrain morphology (HP:0002418)2.40724323
49Molar tooth sign on MRI (HP:0002419)2.40724323
50Aplasia involving forearm bones (HP:0009822)2.40626761
51Absent forearm bone (HP:0003953)2.40626761
52Rhabdomyosarcoma (HP:0002859)2.40228516
53Hyperinsulinemic hypoglycemia (HP:0000825)2.39060834
54Abnormal gallbladder physiology (HP:0012438)2.38027565
55Cholecystitis (HP:0001082)2.38027565
56Chronic hepatic failure (HP:0100626)2.36748216
57Abnormal hair whorl (HP:0010721)2.36041766
58Postaxial foot polydactyly (HP:0001830)2.31424577
59Progressive inability to walk (HP:0002505)2.28807976
60Abnormal lung lobation (HP:0002101)2.27531561
61Anophthalmia (HP:0000528)2.27188673
62Anencephaly (HP:0002323)2.23531172
63Facial hemangioma (HP:0000329)2.23417477
64Abnormal respiratory motile cilium physiology (HP:0012261)2.22367108
65Congenital cataract (HP:0000519)2.22182595
66Abnormality of the aortic arch (HP:0012303)2.19822615
67Hepatic necrosis (HP:0002605)2.18687132
68Bony spicule pigmentary retinopathy (HP:0007737)2.18405250
69Ependymoma (HP:0002888)2.18065268
70Carpal bone hypoplasia (HP:0001498)2.16629688
71Pili torti (HP:0003777)2.11590740
72Poor head control (HP:0002421)2.09432193
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08427532
74Volvulus (HP:0002580)2.07294310
75Sensory axonal neuropathy (HP:0003390)2.07042514
76Microvesicular hepatic steatosis (HP:0001414)2.06232363
77Male pseudohermaphroditism (HP:0000037)2.05638651
78Abnormality of endocrine pancreas physiology (HP:0012093)2.05064086
79Abnormality of the pancreatic islet cells (HP:0006476)2.05064086
80Microglossia (HP:0000171)2.04428612
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03166758
823-Methylglutaconic aciduria (HP:0003535)2.02169021
83Abnormality of the labia minora (HP:0012880)1.98263543
84Progressive muscle weakness (HP:0003323)1.94012534
85Hypergonadotropic hypogonadism (HP:0000815)1.93395782
86Astigmatism (HP:0000483)1.92728423
87Hepatocellular necrosis (HP:0001404)1.92337726
88Cystic liver disease (HP:0006706)1.90262096
89Elfin facies (HP:0004428)1.90109371
90Duplication of thumb phalanx (HP:0009942)1.89057227
91Optic nerve hypoplasia (HP:0000609)1.88769181
92Congenital hepatic fibrosis (HP:0002612)1.87793330
93Gastrointestinal atresia (HP:0002589)1.87383042
94Cortical dysplasia (HP:0002539)1.86883337
95Inability to walk (HP:0002540)1.86190690
96Small epiphyses (HP:0010585)1.85110078
97Generalized aminoaciduria (HP:0002909)1.84354114
98Capillary hemangiomas (HP:0005306)1.84304862
99Aganglionic megacolon (HP:0002251)1.84166731
100Holoprosencephaly (HP:0001360)1.84019548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.13998169
2MAP3K104.32457548
3LATS13.70400623
4VRK23.55977606
5ZAK3.49526283
6NUAK12.91476228
7CDC72.88266323
8JAK32.88103484
9PINK12.63617990
10BMPR1B2.06075861
11CCNB12.05636635
12VRK11.82078616
13CAMK1D1.71369180
14ADRBK21.69275994
15SRPK11.63983351
16FRK1.62940773
17NEK11.58791335
18CAMK1G1.54377339
19BUB11.54062457
20TTK1.50906608
21BRSK21.50154040
22PIK3CG1.46628314
23STK31.38530578
24CDK31.36389145
25PASK1.35357276
26CHEK21.33754212
27EPHA41.30977785
28TGFBR11.26886913
29MAP3K121.21228311
30WEE11.15772255
31MAP4K21.14126782
32STK38L1.13432806
33BCKDK1.12171841
34GRK71.10652378
35STK391.06299091
36PLK11.05480016
37CDK81.02769147
38MAP3K41.02281496
39MKNK21.01677597
40MKNK10.99214233
41FGFR20.98954032
42PLK40.98838447
43CSNK1G30.96678097
44ATM0.95423079
45MAP2K70.92096252
46PLK30.91522867
47TLK10.86072538
48MINK10.85885571
49CSNK1A1L0.84406011
50OBSCN0.83508948
51BCR0.83177318
52TAOK10.81917930
53ATR0.81507198
54STK160.81345669
55MAPK130.81275132
56NME10.79032765
57PNCK0.77023949
58OXSR10.76579651
59CSNK1G10.76260667
60AURKB0.75388165
61WNK40.72345296
62DYRK20.68645825
63BRSK10.65213926
64MST1R0.65057511
65MOS0.64592900
66MYLK0.60773923
67GRK50.60227951
68MAPK150.59596578
69CSNK1G20.59014384
70MARK30.57492501
71PTK2B0.55550878
72TIE10.49715992
73GRK10.49536982
74MAPKAPK50.48404080
75AKT20.47665053
76CHEK10.45624995
77NTRK20.43855184
78CSNK1D0.42181041
79NEK20.40860061
80MET0.40821357
81AURKA0.38437236
82CASK0.38185231
83CSNK1A10.37625614
84CDK70.36409848
85PRKCE0.35538023
86PRKD30.35365749
87PHKG20.34582669
88PHKG10.34582669
89RPS6KB10.34126538
90CSNK2A10.28211626
91CLK10.27326025
92WNK30.26417381
93PRKCB0.25926161
94PRKDC0.25461299
95CSNK2A20.24372214
96CDK10.23989580
97IRAK10.23409057
98EIF2AK20.22906882
99ADRBK10.22005266
100MAP3K50.21580202

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.64759899
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005344.43466927
3DNA replication_Homo sapiens_hsa030304.41944289
4Homologous recombination_Homo sapiens_hsa034404.29056846
5Base excision repair_Homo sapiens_hsa034102.85680379
6Mismatch repair_Homo sapiens_hsa034302.81886888
7RNA polymerase_Homo sapiens_hsa030202.81565454
8Spliceosome_Homo sapiens_hsa030402.34193422
9Protein export_Homo sapiens_hsa030602.25038684
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23534395
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18979480
12Cell cycle_Homo sapiens_hsa041101.99492397
13Olfactory transduction_Homo sapiens_hsa047401.95186070
14Pyrimidine metabolism_Homo sapiens_hsa002401.88597309
15Oxidative phosphorylation_Homo sapiens_hsa001901.86033488
16Non-homologous end-joining_Homo sapiens_hsa034501.76872915
17Parkinsons disease_Homo sapiens_hsa050121.74646429
18Huntingtons disease_Homo sapiens_hsa050161.71165845
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68709113
20Proteasome_Homo sapiens_hsa030501.68486557
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64646799
22Histidine metabolism_Homo sapiens_hsa003401.60468167
23Purine metabolism_Homo sapiens_hsa002301.52530135
24Nucleotide excision repair_Homo sapiens_hsa034201.51748920
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51318873
26Basal transcription factors_Homo sapiens_hsa030221.47023451
27Hedgehog signaling pathway_Homo sapiens_hsa043401.38526893
28One carbon pool by folate_Homo sapiens_hsa006701.37698111
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25185796
30Ribosome_Homo sapiens_hsa030101.18379666
31RNA transport_Homo sapiens_hsa030131.11838357
32Alzheimers disease_Homo sapiens_hsa050101.09949867
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05768490
34beta-Alanine metabolism_Homo sapiens_hsa004101.05484231
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02789672
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00986418
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00412735
38Arginine and proline metabolism_Homo sapiens_hsa003300.98937724
39Butanoate metabolism_Homo sapiens_hsa006500.96396285
40Oocyte meiosis_Homo sapiens_hsa041140.93882741
41Selenocompound metabolism_Homo sapiens_hsa004500.91797722
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89182031
43RNA degradation_Homo sapiens_hsa030180.86984353
44Cardiac muscle contraction_Homo sapiens_hsa042600.83257219
45Chemical carcinogenesis_Homo sapiens_hsa052040.82946565
46Basal cell carcinoma_Homo sapiens_hsa052170.82845366
47Glutathione metabolism_Homo sapiens_hsa004800.77259365
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71935089
49Metabolic pathways_Homo sapiens_hsa011000.71885725
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.70906028
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70266712
52Nitrogen metabolism_Homo sapiens_hsa009100.69824155
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.69349061
54Steroid biosynthesis_Homo sapiens_hsa001000.66748889
55Regulation of autophagy_Homo sapiens_hsa041400.66602282
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66211731
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61191500
58Phenylalanine metabolism_Homo sapiens_hsa003600.57045599
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56604728
60Lysine degradation_Homo sapiens_hsa003100.55303436
61Ovarian steroidogenesis_Homo sapiens_hsa049130.54067224
62Fructose and mannose metabolism_Homo sapiens_hsa000510.53317504
63Propanoate metabolism_Homo sapiens_hsa006400.51923207
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.50653574
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50048267
66Pyruvate metabolism_Homo sapiens_hsa006200.49870706
67Taste transduction_Homo sapiens_hsa047420.48850106
68Tyrosine metabolism_Homo sapiens_hsa003500.48813517
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.48418918
70Phototransduction_Homo sapiens_hsa047440.45275529
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44443539
72Tryptophan metabolism_Homo sapiens_hsa003800.42400434
73Biosynthesis of amino acids_Homo sapiens_hsa012300.41651390
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41237432
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40945781
76TGF-beta signaling pathway_Homo sapiens_hsa043500.39699120
77Glycerolipid metabolism_Homo sapiens_hsa005610.38150396
78p53 signaling pathway_Homo sapiens_hsa041150.37804529
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34623766
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34188827
81Salivary secretion_Homo sapiens_hsa049700.33686856
82Dorso-ventral axis formation_Homo sapiens_hsa043200.30455452
83Sphingolipid metabolism_Homo sapiens_hsa006000.30232084
84Wnt signaling pathway_Homo sapiens_hsa043100.28827658
85Peroxisome_Homo sapiens_hsa041460.28677738
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28177881
87Folate biosynthesis_Homo sapiens_hsa007900.27073731
88HTLV-I infection_Homo sapiens_hsa051660.25990265
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25762013
90N-Glycan biosynthesis_Homo sapiens_hsa005100.23032209
91Legionellosis_Homo sapiens_hsa051340.22845285
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22793422
93Retinol metabolism_Homo sapiens_hsa008300.20191182
94Axon guidance_Homo sapiens_hsa043600.19523712
95GABAergic synapse_Homo sapiens_hsa047270.19445958
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.18745590
97Hippo signaling pathway_Homo sapiens_hsa043900.17553940
98Fatty acid elongation_Homo sapiens_hsa000620.16562253
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.14774326
100mRNA surveillance pathway_Homo sapiens_hsa030150.14365325

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