ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	8.35043927
2	piRNA metabolic process (GO:0034587)	7.91859926
3	male meiosis I (GO:0007141)	7.06727102
4	male meiosis (GO:0007140)	6.60941220
5	chromosome organization involved in meiosis (GO:0070192)	6.51777221
6	DNA methylation involved in gamete generation (GO:0043046)	6.03807074
7	synaptonemal complex assembly (GO:0007130)	5.77635534
8	meiosis I (GO:0007127)	5.59515368
9	meiotic nuclear division (GO:0007126)	5.30495011
10	synaptonemal complex organization (GO:0070193)	5.10093333
11	DNA synthesis involved in DNA repair (GO:0000731)	4.89704440
12	intraciliary transport (GO:0042073)	4.71957302
13	positive regulation of mitochondrial fission (GO:0090141)	4.56333028
14	sister chromatid cohesion (GO:0007062)	4.54120291
15	glycerophospholipid catabolic process (GO:0046475)	4.36673977
16	resolution of meiotic recombination intermediates (GO:0000712)	4.00390798
17	reciprocal DNA recombination (GO:0035825)	3.93350858
18	reciprocal meiotic recombination (GO:0007131)	3.93350858
19	meiotic cell cycle process (GO:1903046)	3.89439478
20	protein localization to cilium (GO:0061512)	3.88657197
21	meiotic chromosome segregation (GO:0045132)	3.75180681
22	microtubule depolymerization (GO:0007019)	3.69237070
23	peroxisome fission (GO:0016559)	3.53668626
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.41951163
25	regulation of cilium movement (GO:0003352)	3.31503452
26	protein localization to synapse (GO:0035418)	3.14303264
27	histone H2A acetylation (GO:0043968)	3.10266637
28	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.06201458
29	anterograde synaptic vesicle transport (GO:0048490)	3.04089767
30	nonmotile primary cilium assembly (GO:0035058)	3.03359355
31	COPII vesicle coating (GO:0048208)	3.00110812
32	regulation of mitochondrial fission (GO:0090140)	2.98857001
33	neuron cell-cell adhesion (GO:0007158)	2.98424900
34	regulation of DNA endoreduplication (GO:0032875)	2.93230308
35	neuronal action potential propagation (GO:0019227)	2.92568747
36	postsynaptic membrane organization (GO:0001941)	2.91602678
37	anterograde axon cargo transport (GO:0008089)	2.89809963
38	negative regulation of axon guidance (GO:1902668)	2.88031046
39	gene silencing by RNA (GO:0031047)	2.87884789
40	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.87065315
41	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.82404822
42	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.82404822
43	adaptation of signaling pathway (GO:0023058)	2.81278855
44	positive regulation of receptor biosynthetic process (GO:0010870)	2.80207071
45	mitotic sister chromatid cohesion (GO:0007064)	2.77830447
46	regulation of microtubule-based movement (GO:0060632)	2.77638334
47	4-hydroxyproline metabolic process (GO:0019471)	2.77311715
48	regulation of meiosis I (GO:0060631)	2.76427442
49	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.75813180
50	presynaptic membrane assembly (GO:0097105)	2.73387207
51	striatum development (GO:0021756)	2.72427711
52	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.71642498
53	regulation of sarcomere organization (GO:0060297)	2.70623795
54	protein-cofactor linkage (GO:0018065)	2.66421128
55	nucleobase catabolic process (GO:0046113)	2.63947108
56	carnitine metabolic process (GO:0009437)	2.63068434
57	negative regulation of inclusion body assembly (GO:0090084)	2.61856805
58	cilium morphogenesis (GO:0060271)	2.58917107
59	C4-dicarboxylate transport (GO:0015740)	2.58687566
60	protein polyglutamylation (GO:0018095)	2.57916866
61	mitotic spindle assembly checkpoint (GO:0007094)	2.56124626
62	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.55353223
63	microtubule-based transport (GO:0010970)	2.55326713
64	glycosphingolipid biosynthetic process (GO:0006688)	2.55043743
65	binding of sperm to zona pellucida (GO:0007339)	2.53143636
66	regulation of heat generation (GO:0031650)	2.52353630
67	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.49442698
68	arginine catabolic process (GO:0006527)	2.49442039
69	mitotic spindle checkpoint (GO:0071174)	2.49328041
70	retinal rod cell development (GO:0046548)	2.48143787
71	spindle assembly checkpoint (GO:0071173)	2.47359055
72	vascular smooth muscle contraction (GO:0014829)	2.46636993
73	cytoskeleton-dependent intracellular transport (GO:0030705)	2.45580237
74	negative regulation of DNA recombination (GO:0045910)	2.44098373
75	response to misfolded protein (GO:0051788)	2.43610468
76	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.42768959
77	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.41859096
78	cilium assembly (GO:0042384)	2.40124451
79	negative regulation of JUN kinase activity (GO:0043508)	2.40042604
80	cilium organization (GO:0044782)	2.39183031
81	axonal fasciculation (GO:0007413)	2.38965070
82	regulation of response to food (GO:0032095)	2.37797611
83	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.36838448
84	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.36838448
85	negative regulation of sister chromatid segregation (GO:0033046)	2.36838448
86	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.36838448
87	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.36838448
88	microtubule polymerization or depolymerization (GO:0031109)	2.36365919
89	gamma-aminobutyric acid transport (GO:0015812)	2.35976737
90	protein refolding (GO:0042026)	2.35871551
91	regulation of sister chromatid cohesion (GO:0007063)	2.34998419
92	heparin metabolic process (GO:0030202)	2.34529347
93	heparin biosynthetic process (GO:0030210)	2.34529347
94	attachment of spindle microtubules to kinetochore (GO:0008608)	2.34351093
95	cellular response to leptin stimulus (GO:0044320)	2.33962143
96	metaphase plate congression (GO:0051310)	2.33012706
97	sterol catabolic process (GO:0016127)	2.32158672
98	cholesterol catabolic process (GO:0006707)	2.32158672
99	translesion synthesis (GO:0019985)	2.31724544
100	histone H4-K16 acetylation (GO:0043984)	2.31718581

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.39221357
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.77395190
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.44388006
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.44191925
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.33421912
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.17336463
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.07320616
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01858513
9	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.76754270
10	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.74355724
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.62342260
12	FUS_26573619_Chip-Seq_HEK293_Human	2.59712102
13	RNF2_27304074_Chip-Seq_NSC_Mouse	2.56102269
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.49917960
15	VDR_22108803_ChIP-Seq_LS180_Human	2.37605714
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.18791456
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.10319208
18	EWS_26573619_Chip-Seq_HEK293_Human	2.10158410
19	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.06965468
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.06931788
21	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.93048495
22	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.89427945
23	P300_19829295_ChIP-Seq_ESCs_Human	1.86418634
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.82012246
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78389587
26	* PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.76991537
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.75665923
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74298918
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.69250695
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68240225
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.68029396
32	E2F7_22180533_ChIP-Seq_HELA_Human	1.65427108
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62283603
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.57893288
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.55968984
36	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.55262214
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.53143345
38	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.52588937
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51894720
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.50069259
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.49202689
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48440342
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42693456
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41682244
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37974244
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.36222527
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35982274
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34177979
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32923660
50	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32464739
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32066718
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31178843
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28797017
54	AR_25329375_ChIP-Seq_VCAP_Human	1.27446121
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26628378
56	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26472335
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26366131
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26336894
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25155110
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24694212
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.21957541
62	STAT3_23295773_ChIP-Seq_U87_Human	1.20311068
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.20158141
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19684646
65	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.18912079
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17063713
67	SOX9_26525672_Chip-Seq_HEART_Mouse	1.15932074
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.15867383
69	HTT_18923047_ChIP-ChIP_STHdh_Human	1.15226805
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12328834
71	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11887413
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11394008
73	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.11039083
74	JUN_21703547_ChIP-Seq_K562_Human	1.10428719
75	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.09794619
76	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.09685410
77	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09582423
78	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.08008249
79	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.06414438
80	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.06304316
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06212624
82	TCF4_23295773_ChIP-Seq_U87_Human	1.06154180
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05510753
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.05359075
85	GABP_19822575_ChIP-Seq_HepG2_Human	1.03424523
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02654119
87	TCF4_22108803_ChIP-Seq_LS180_Human	1.02173690
88	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02118323
89	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02118323
90	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01725225
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01084307
92	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.00175666
93	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.99731932
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98443878
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98099797
96	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95845379
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.94066280
98	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.93686005
99	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92019180
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92014430

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	6.05759120
2	MP0008058_abnormal_DNA_repair	2.87861426
3	MP0002210_abnormal_sex_determination	2.61473530
4	MP0005645_abnormal_hypothalamus_physiol	2.55745414
5	MP0002160_abnormal_reproductive_system	2.33514263
6	MP0000569_abnormal_digit_pigmentation	2.30327646
7	MP0000778_abnormal_nervous_system	2.24654755
8	MP0003122_maternal_imprinting	2.18638291
9	MP0001929_abnormal_gametogenesis	2.13656567
10	MP0002102_abnormal_ear_morphology	2.07541884
11	MP0008789_abnormal_olfactory_epithelium	2.02931132
12	MP0003880_abnormal_central_pattern	2.00966116
13	MP0001984_abnormal_olfaction	1.98578185
14	MP0005551_abnormal_eye_electrophysiolog	1.93779321
15	MP0001145_abnormal_male_reproductive	1.91614609
16	MP0000653_abnormal_sex_gland	1.91408559
17	MP0002234_abnormal_pharynx_morphology	1.88927041
18	MP0009697_abnormal_copulation	1.86328928
19	MP0003698_abnormal_male_reproductive	1.85238331
20	MP0001502_abnormal_circadian_rhythm	1.80580801
21	MP0004859_abnormal_synaptic_plasticity	1.79014402
22	MP0003121_genomic_imprinting	1.76350135
23	MP0006292_abnormal_olfactory_placode	1.70407087
24	MP0001486_abnormal_startle_reflex	1.64290305
25	MP0002736_abnormal_nociception_after	1.52903568
26	MP0002272_abnormal_nervous_system	1.50979472
27	MP0001764_abnormal_homeostasis	1.50714982
28	MP0005394_taste/olfaction_phenotype	1.49822965
29	MP0005499_abnormal_olfactory_system	1.49822965
30	MP0006276_abnormal_autonomic_nervous	1.37392820
31	MP0003635_abnormal_synaptic_transmissio	1.34638501
32	MP0003786_premature_aging	1.33434486
33	MP0003943_abnormal_hepatobiliary_system	1.31960601
34	MP0009780_abnormal_chondrocyte_physiolo	1.30185594
35	MP0005174_abnormal_tail_pigmentation	1.28841407
36	MP0003938_abnormal_ear_development	1.27261424
37	MP0000751_myopathy	1.26907503
38	MP0002090_abnormal_vision	1.26231341
39	MP0002063_abnormal_learning/memory/cond	1.25259754
40	MP0009046_muscle_twitch	1.23070835
41	MP0003111_abnormal_nucleus_morphology	1.20835102
42	MP0001299_abnormal_eye_distance/	1.19368232
43	MP0009745_abnormal_behavioral_response	1.18777973
44	MP0008995_early_reproductive_senescence	1.16915413
45	MP0000358_abnormal_cell_content/	1.14724796
46	MP0002638_abnormal_pupillary_reflex	1.13035446
47	MP0005389_reproductive_system_phenotype	1.12648514
48	MP0002909_abnormal_adrenal_gland	1.12466793
49	MP0005253_abnormal_eye_physiology	1.10973448
50	MP0002064_seizures	1.10900969
51	MP0002572_abnormal_emotion/affect_behav	1.08174917
52	MP0002184_abnormal_innervation	1.07933208
53	MP0001119_abnormal_female_reproductive	1.07607249
54	MP0004811_abnormal_neuron_physiology	1.07140322
55	MP0002161_abnormal_fertility/fecundity	1.06569649
56	MP0000427_abnormal_hair_cycle	1.06169355
57	MP0004233_abnormal_muscle_weight	1.05660943
58	MP0002067_abnormal_sensory_capabilities	1.04314624
59	MP0001968_abnormal_touch/_nociception	1.03899189
60	MP0002233_abnormal_nose_morphology	1.03725056
61	MP0000955_abnormal_spinal_cord	1.02837806
62	MP0002152_abnormal_brain_morphology	1.02667088
63	MP0004215_abnormal_myocardial_fiber	1.01659549
64	MP0001529_abnormal_vocalization	1.01650869
65	MP0002882_abnormal_neuron_morphology	1.00937345
66	MP0002734_abnormal_mechanical_nocicepti	0.99335049
67	MP0005367_renal/urinary_system_phenotyp	0.98064828
68	MP0000516_abnormal_urinary_system	0.98064828
69	MP0009703_decreased_birth_body	0.97189646
70	MP0003718_maternal_effect	0.96537425
71	MP0003868_abnormal_feces_composition	0.95689536
72	MP0005423_abnormal_somatic_nervous	0.95246723
73	MP0004270_analgesia	0.95040969
74	MP0003633_abnormal_nervous_system	0.94299541
75	MP0002249_abnormal_larynx_morphology	0.94069375
76	MP0006072_abnormal_retinal_apoptosis	0.93590200
77	MP0003937_abnormal_limbs/digits/tail_de	0.92153658
78	MP0005646_abnormal_pituitary_gland	0.90693316
79	MP0002697_abnormal_eye_size	0.89709216
80	MP0003186_abnormal_redox_activity	0.89562306
81	MP0001346_abnormal_lacrimal_gland	0.89471673
82	MP0006036_abnormal_mitochondrial_physio	0.89381762
83	MP0001542_abnormal_bone_strength	0.86051869
84	MP0001485_abnormal_pinna_reflex	0.85693991
85	MP0002332_abnormal_exercise_endurance	0.84970934
86	MP0002557_abnormal_social/conspecific_i	0.84886696
87	MP0003221_abnormal_cardiomyocyte_apopto	0.81104102
88	MP0003631_nervous_system_phenotype	0.80254669
89	MP0005365_abnormal_bile_salt	0.77593225
90	MP0005395_other_phenotype	0.77446179
91	MP0000631_abnormal_neuroendocrine_gland	0.75822853
92	MP0008007_abnormal_cellular_replicative	0.75455225
93	MP0002066_abnormal_motor_capabilities/c	0.75343883
94	MP0000013_abnormal_adipose_tissue	0.75059533
95	MP0003861_abnormal_nervous_system	0.74390496
96	MP0003806_abnormal_nucleotide_metabolis	0.74150646
97	MP0002751_abnormal_autonomic_nervous	0.73925971
98	MP0002735_abnormal_chemical_nociception	0.73152441
99	MP0002177_abnormal_outer_ear	0.72844230
100	MP0003755_abnormal_palate_morphology	0.71531928

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the lower motor neuron (HP:0002366)	4.31964012
2	Volvulus (HP:0002580)	3.74270795
3	Nephrogenic diabetes insipidus (HP:0009806)	3.50797107
4	Shoulder girdle muscle weakness (HP:0003547)	3.48607869
5	Abnormality of the labia minora (HP:0012880)	3.39687074
6	Medial flaring of the eyebrow (HP:0010747)	3.38913243
7	Amyotrophic lateral sclerosis (HP:0007354)	3.33553921
8	Gait imbalance (HP:0002141)	3.20101084
9	Oligodactyly (hands) (HP:0001180)	3.15548259
10	Congenital primary aphakia (HP:0007707)	3.13051133
11	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.10700511
12	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.10700511
13	Polyphagia (HP:0002591)	2.98809359
14	Abnormality of midbrain morphology (HP:0002418)	2.95420554
15	Molar tooth sign on MRI (HP:0002419)	2.95420554
16	Impaired vibration sensation in the lower limbs (HP:0002166)	2.78967218
17	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.71853629
18	Hemiparesis (HP:0001269)	2.67468428
19	Failure to thrive in infancy (HP:0001531)	2.66076197
20	Abnormal lung lobation (HP:0002101)	2.65906741
21	Oligodactyly (HP:0012165)	2.60187032
22	Decreased muscle mass (HP:0003199)	2.50658797
23	Chromsome breakage (HP:0040012)	2.48327608
24	True hermaphroditism (HP:0010459)	2.42964153
25	Methylmalonic acidemia (HP:0002912)	2.38664495
26	Abnormality of the corticospinal tract (HP:0002492)	2.38252582
27	Abnormal protein N-linked glycosylation (HP:0012347)	2.38002183
28	Abnormal protein glycosylation (HP:0012346)	2.38002183
29	Abnormal glycosylation (HP:0012345)	2.38002183
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.38002183
31	Pancreatic fibrosis (HP:0100732)	2.37802343
32	Abnormal hair whorl (HP:0010721)	2.37762733
33	Nephronophthisis (HP:0000090)	2.36138779
34	Hypoplastic nipples (HP:0002557)	2.33600734
35	Wrist flexion contracture (HP:0001239)	2.27976505
36	Cortical dysplasia (HP:0002539)	2.26719130
37	Type I transferrin isoform profile (HP:0003642)	2.26179062
38	Prolonged partial thromboplastin time (HP:0003645)	2.19605442
39	Facial hemangioma (HP:0000329)	2.17913755
40	Hip dysplasia (HP:0001385)	2.17473524
41	Delayed gross motor development (HP:0002194)	2.17185289
42	Abnormal neuron morphology (HP:0012757)	2.15204848
43	Abnormality of the motor neurons (HP:0002450)	2.15204848
44	Abnormal gallbladder physiology (HP:0012438)	2.12359135
45	Cholecystitis (HP:0001082)	2.12359135
46	Genital tract atresia (HP:0001827)	2.11962331
47	Broad distal phalanx of finger (HP:0009836)	2.11718491
48	Multicystic kidney dysplasia (HP:0000003)	2.09711870
49	Esotropia (HP:0000565)	2.08658474
50	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.08403628
51	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.06937162
52	Abnormal biliary tract physiology (HP:0012439)	2.05703608
53	Bile duct proliferation (HP:0001408)	2.05703608
54	Postaxial foot polydactyly (HP:0001830)	2.05343074
55	Lissencephaly (HP:0001339)	2.04788607
56	Rimmed vacuoles (HP:0003805)	2.04745987
57	Urinary urgency (HP:0000012)	2.04652915
58	Gonadotropin excess (HP:0000837)	2.04541213
59	Buphthalmos (HP:0000557)	2.04125449
60	3-Methylglutaconic aciduria (HP:0003535)	2.03561599
61	Vaginal atresia (HP:0000148)	2.03536463
62	Increased nuchal translucency (HP:0010880)	2.03420821
63	Tubulointerstitial nephritis (HP:0001970)	2.03071415
64	Broad foot (HP:0001769)	2.00715293
65	Nephroblastoma (Wilms tumor) (HP:0002667)	1.99872352
66	Embryonal renal neoplasm (HP:0011794)	1.98809697
67	Decreased testicular size (HP:0008734)	1.97895134
68	Short nail (HP:0001799)	1.97406873
69	Upper motor neuron abnormality (HP:0002127)	1.95817089
70	Hypoplastic iliac wings (HP:0002866)	1.95644009
71	Focal motor seizures (HP:0011153)	1.94350704
72	Oculomotor apraxia (HP:0000657)	1.93161008
73	Hyperventilation (HP:0002883)	1.92135907
74	Hepatic necrosis (HP:0002605)	1.91457820
75	Specific learning disability (HP:0001328)	1.89087103
76	Progressive inability to walk (HP:0002505)	1.88063038
77	11 pairs of ribs (HP:0000878)	1.86474578
78	Hypoplastic pelvis (HP:0008839)	1.84905498
79	Pendular nystagmus (HP:0012043)	1.84699768
80	Poor coordination (HP:0002370)	1.84394398
81	Pancreatic cysts (HP:0001737)	1.83991238
82	Hepatocellular necrosis (HP:0001404)	1.80478181
83	Aplasia/Hypoplasia of the lens (HP:0008063)	1.80130674
84	Small intestinal stenosis (HP:0012848)	1.78416619
85	Duodenal stenosis (HP:0100867)	1.78416619
86	Horizontal nystagmus (HP:0000666)	1.77146451
87	Proximal tubulopathy (HP:0000114)	1.74959377
88	Abnormality of the renal medulla (HP:0100957)	1.72831573
89	Abnormality of the hip-girdle musculature (HP:0001445)	1.72480600
90	Abnormality of the musculature of the pelvis (HP:0001469)	1.72480600
91	Secondary amenorrhea (HP:0000869)	1.72239765
92	Drooling (HP:0002307)	1.72213553
93	Short tibia (HP:0005736)	1.71667332
94	Abnormality of the intrinsic pathway (HP:0010989)	1.71332846
95	Brushfield spots (HP:0001088)	1.69887493
96	Methylmalonic aciduria (HP:0012120)	1.69714501
97	Micropenis (HP:0000054)	1.69376674
98	Narrow forehead (HP:0000341)	1.68491165
99	Tubulointerstitial abnormality (HP:0001969)	1.67477315
100	Abnormal eating behavior (HP:0100738)	1.67426094

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.73890810
2	PINK1	3.52776608
3	MAP4K2	3.39006471
4	STK38L	2.65949484
5	MARK1	2.63109074
6	MAP3K12	2.41366900
7	CDK19	2.23055433
8	PDK2	2.11776163
9	NUAK1	1.91809264
10	PLK2	1.88513946
11	MET	1.88056034
12	CASK	1.83557061
13	MAP3K4	1.83468279
14	MAP2K7	1.80495312
15	MAPK13	1.75602823
16	NEK1	1.70700525
17	EIF2AK3	1.66850495
18	FRK	1.62370398
19	BUB1	1.61070812
20	CSNK1G2	1.60285100
21	CAMK1G	1.58744191
22	UHMK1	1.55298502
23	ERBB3	1.48809286
24	EPHA4	1.43854745
25	CSNK1G3	1.43471943
26	PTK2B	1.40380301
27	PLK4	1.36544279
28	EPHA3	1.36080311
29	WNK3	1.34630361
30	TRIM28	1.32131066
31	BRD4	1.31558771
32	BCR	1.31548319
33	CSNK1G1	1.31216779
34	WEE1	1.22969052
35	STK16	1.18512099
36	CSNK1A1L	1.13644646
37	PAK3	1.11020586
38	OXSR1	1.10294287
39	SIK2	1.09568878
40	RET	1.03675665
41	MAP3K5	1.03634367
42	BCKDK	0.96696584
43	LATS1	0.95460461
44	PRKCE	0.95248154
45	STK38	0.94444847
46	NTRK2	0.92221920
47	NTRK3	0.89124888
48	IRAK1	0.87855908
49	CDC7	0.87820201
50	MAP2K4	0.85096749
51	BMPR1B	0.84034049
52	BMX	0.83397681
53	PRKCG	0.81403198
54	DYRK1A	0.81211774
55	INSRR	0.80217697
56	PLK1	0.79658462
57	FGFR1	0.75737179
58	STK39	0.74982071
59	MINK1	0.73387792
60	WNK4	0.73056109
61	LIMK1	0.72528145
62	CDK3	0.68564213
63	EIF2AK1	0.68547264
64	ROCK1	0.67512251
65	TNIK	0.67002728
66	PKN2	0.66936498
67	ATM	0.59848758
68	IRAK2	0.59346942
69	FLT3	0.57597225
70	PLK3	0.57037760
71	FER	0.56723888
72	DAPK2	0.55015085
73	CDK11A	0.54467281
74	DYRK2	0.54267283
75	ACVR1B	0.54101180
76	CDK14	0.52975443
77	SIK3	0.52763488
78	PHKG1	0.50711932
79	PHKG2	0.50711932
80	CDK5	0.50453492
81	TSSK6	0.50030230
82	PAK6	0.49117113
83	DYRK3	0.46529444
84	MAP3K11	0.46206768
85	MAP3K6	0.45936737
86	PRKCI	0.45505551
87	CDK18	0.44878573
88	KSR1	0.44741089
89	CDK15	0.42537370
90	TTK	0.42386015
91	BRSK1	0.42333934
92	PIK3CG	0.39053806
93	SGK1	0.38220193
94	PRKD2	0.38178232
95	RAF1	0.37685843
96	FGFR2	0.37467161
97	ZAK	0.37244870
98	PRKCQ	0.36932761
99	PRKCZ	0.36388754
100	CDK8	0.36112405

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.74435972
2	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.80971754
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.47798295
4	Homologous recombination_Homo sapiens_hsa03440	2.34887072
5	Steroid biosynthesis_Homo sapiens_hsa00100	1.97800587
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.97215003
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.95929246
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.89195626
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89046443
10	Butanoate metabolism_Homo sapiens_hsa00650	1.88616498
11	Propanoate metabolism_Homo sapiens_hsa00640	1.85041207
12	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.82675829
13	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.78992241
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.77402832
15	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.71732120
16	beta-Alanine metabolism_Homo sapiens_hsa00410	1.70047045
17	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.66808825
18	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.65923302
19	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.61793560
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.60197120
21	Mismatch repair_Homo sapiens_hsa03430	1.59837218
22	Oocyte meiosis_Homo sapiens_hsa04114	1.59803802
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.53238658
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.51800356
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.51480205
26	Base excision repair_Homo sapiens_hsa03410	1.48814679
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47337377
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.41595771
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.41492801
30	Fatty acid degradation_Homo sapiens_hsa00071	1.37273546
31	Fatty acid elongation_Homo sapiens_hsa00062	1.36883997
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.34498677
33	Peroxisome_Homo sapiens_hsa04146	1.33658018
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32089512
35	Sulfur relay system_Homo sapiens_hsa04122	1.29170233
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.27214097
37	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.26632667
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26445602
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.25112029
40	Cell cycle_Homo sapiens_hsa04110	1.24574629
41	Carbon metabolism_Homo sapiens_hsa01200	1.23823718
42	Lysine degradation_Homo sapiens_hsa00310	1.23490770
43	Protein export_Homo sapiens_hsa03060	1.23061343
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.18673822
45	RNA polymerase_Homo sapiens_hsa03020	1.17088386
46	Arginine and proline metabolism_Homo sapiens_hsa00330	1.09090409
47	Basal transcription factors_Homo sapiens_hsa03022	1.08007953
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06722993
49	mRNA surveillance pathway_Homo sapiens_hsa03015	1.03386096
50	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.00526007
51	Nicotine addiction_Homo sapiens_hsa05033	0.99523196
52	RNA transport_Homo sapiens_hsa03013	0.97778675
53	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.96213521
54	Circadian rhythm_Homo sapiens_hsa04710	0.93226054
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90515921
56	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.87712290
57	Phototransduction_Homo sapiens_hsa04744	0.84928825
58	Proteasome_Homo sapiens_hsa03050	0.84096864
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.82881969
60	DNA replication_Homo sapiens_hsa03030	0.80631967
61	GABAergic synapse_Homo sapiens_hsa04727	0.79015511
62	RNA degradation_Homo sapiens_hsa03018	0.78744008
63	Amphetamine addiction_Homo sapiens_hsa05031	0.78650368
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.76068836
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.75689632
66	Retinol metabolism_Homo sapiens_hsa00830	0.69029711
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65568189
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.64960241
69	Huntingtons disease_Homo sapiens_hsa05016	0.63099962
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.62299027
71	Circadian entrainment_Homo sapiens_hsa04713	0.61965175
72	Histidine metabolism_Homo sapiens_hsa00340	0.61872852
73	Cocaine addiction_Homo sapiens_hsa05030	0.60803264
74	Metabolic pathways_Homo sapiens_hsa01100	0.60325294
75	Parkinsons disease_Homo sapiens_hsa05012	0.59909381
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58424739
77	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.56142237
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.55580795
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55497850
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.48874007
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.48717552
82	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47831798
83	Linoleic acid metabolism_Homo sapiens_hsa00591	0.47152692
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45128113
85	Olfactory transduction_Homo sapiens_hsa04740	0.45027336
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43684022
87	Complement and coagulation cascades_Homo sapiens_hsa04610	0.41261012
88	Regulation of autophagy_Homo sapiens_hsa04140	0.39041751
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38866157
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38673049
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38480370
92	Axon guidance_Homo sapiens_hsa04360	0.36847284
93	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.36606465
94	Oxidative phosphorylation_Homo sapiens_hsa00190	0.34847061
95	Pentose phosphate pathway_Homo sapiens_hsa00030	0.34664669
96	Purine metabolism_Homo sapiens_hsa00230	0.33032956
97	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31952115
98	Morphine addiction_Homo sapiens_hsa05032	0.31732714
99	p53 signaling pathway_Homo sapiens_hsa04115	0.30531499
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.29961657

RAB41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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