RAB42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.66895983
2proline metabolic process (GO:0006560)8.38040806
3replication fork processing (GO:0031297)7.86873028
4embryonic process involved in female pregnancy (GO:0060136)7.66537062
5positive regulation of protein homooligomerization (GO:0032464)7.42419476
6DNA deamination (GO:0045006)6.79734851
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.42338408
8oxidative demethylation (GO:0070989)6.40728788
9regulation of protein homooligomerization (GO:0032462)6.40495506
10establishment of apical/basal cell polarity (GO:0035089)6.36088125
11regulation of integrin activation (GO:0033623)6.27526896
12establishment of protein localization to mitochondrial membrane (GO:0090151)6.12738863
13establishment or maintenance of monopolar cell polarity (GO:0061339)5.54392986
14establishment of monopolar cell polarity (GO:0061162)5.54392986
15DNA strand renaturation (GO:0000733)5.46748110
16mitochondrial DNA metabolic process (GO:0032042)5.46020236
17negative regulation of JAK-STAT cascade (GO:0046426)5.37258263
18low-density lipoprotein particle remodeling (GO:0034374)5.35645324
19poly(A)+ mRNA export from nucleus (GO:0016973)5.33125426
20cellular response to ATP (GO:0071318)5.20833529
21very-low-density lipoprotein particle assembly (GO:0034379)5.19826055
22oligosaccharide catabolic process (GO:0009313)5.09800520
23viral mRNA export from host cell nucleus (GO:0046784)5.04266911
24somatic diversification of immune receptors via somatic mutation (GO:0002566)4.99513736
25somatic hypermutation of immunoglobulin genes (GO:0016446)4.99513736
26cholesterol efflux (GO:0033344)4.73975076
27negative regulation of protein oligomerization (GO:0032460)4.63183081
28plasma lipoprotein particle assembly (GO:0034377)4.62606483
29negative regulation of cell cycle arrest (GO:0071157)4.55939001
30mitotic G1 DNA damage checkpoint (GO:0031571)4.50632228
31DNA integration (GO:0015074)4.49328966
32water-soluble vitamin biosynthetic process (GO:0042364)4.47345811
33glial cell migration (GO:0008347)4.41684054
34negative regulation of Ras GTPase activity (GO:0034261)4.40237538
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.36477347
36plasma lipoprotein particle clearance (GO:0034381)4.36187737
37protein-lipid complex remodeling (GO:0034368)4.35362270
38macromolecular complex remodeling (GO:0034367)4.35362270
39plasma lipoprotein particle remodeling (GO:0034369)4.35362270
40intestinal cholesterol absorption (GO:0030299)4.31318809
41embryonic placenta development (GO:0001892)4.29276412
42glutamine family amino acid biosynthetic process (GO:0009084)4.20025110
43convergent extension (GO:0060026)4.18796994
44positive regulation of developmental pigmentation (GO:0048087)4.14805137
45regulation of protein oligomerization (GO:0032459)4.10952578
46cellular response to zinc ion (GO:0071294)4.10180957
47mRNA cleavage (GO:0006379)4.09951847
48G1 DNA damage checkpoint (GO:0044783)4.07972154
49positive regulation of protein oligomerization (GO:0032461)4.07200817
50high-density lipoprotein particle remodeling (GO:0034375)4.05942571
51regulation of cholesterol esterification (GO:0010872)4.05853477
52plasma lipoprotein particle organization (GO:0071827)4.04369396
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.99159584
54regulation of cAMP-dependent protein kinase activity (GO:2000479)3.98818959
55embryonic camera-type eye development (GO:0031076)3.97873105
56mitotic G1/S transition checkpoint (GO:0044819)3.91132746
57formation of translation preinitiation complex (GO:0001731)3.89908282
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.89094201
59auditory receptor cell stereocilium organization (GO:0060088)3.86268624
60DNA double-strand break processing (GO:0000729)3.85787968
61positive regulation of receptor recycling (GO:0001921)3.82310170
62base-excision repair, AP site formation (GO:0006285)3.81656051
63protein-lipid complex assembly (GO:0065005)3.80826975
64negative regulation of fatty acid biosynthetic process (GO:0045717)3.80325541
65regulation of translational fidelity (GO:0006450)3.78465823
66GDP-mannose metabolic process (GO:0019673)3.78303202
67base-excision repair (GO:0006284)3.78208928
68face development (GO:0060324)3.76736592
69regulation of mitochondrial depolarization (GO:0051900)3.76247488
70negative regulation of heart rate (GO:0010459)3.76050869
71maturation of 5.8S rRNA (GO:0000460)3.73841626
72positive regulation of DNA repair (GO:0045739)3.72181362
73non-recombinational repair (GO:0000726)3.69974347
74double-strand break repair via nonhomologous end joining (GO:0006303)3.69974347
75positive regulation by host of viral transcription (GO:0043923)3.67081978
76negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.66964960
77nephron tubule morphogenesis (GO:0072078)3.65414646
78nephron epithelium morphogenesis (GO:0072088)3.65414646
79alkaloid metabolic process (GO:0009820)3.64471278
80protein-lipid complex subunit organization (GO:0071825)3.63291913
81reverse cholesterol transport (GO:0043691)3.61221162
82negative regulation of response to food (GO:0032096)3.58994324
83negative regulation of appetite (GO:0032099)3.58994324
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58783991
85amino sugar catabolic process (GO:0046348)3.58692606
86regulation of prostaglandin secretion (GO:0032306)3.57443493
87mitochondrial RNA metabolic process (GO:0000959)3.57122479
88epithelial cilium movement (GO:0003351)3.54723760
89vitamin biosynthetic process (GO:0009110)3.51411623
90behavioral response to nicotine (GO:0035095)3.50968972
91N-acetylneuraminate metabolic process (GO:0006054)3.50711177
92synaptic vesicle endocytosis (GO:0048488)3.50632124
93triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.48967165
94negative regulation of mast cell activation (GO:0033004)3.47015157
95signal complex assembly (GO:0007172)3.46880129
96indole-containing compound catabolic process (GO:0042436)3.45936784
97indolalkylamine catabolic process (GO:0046218)3.45936784
98tryptophan catabolic process (GO:0006569)3.45936784
99L-fucose catabolic process (GO:0042355)3.43547624
100fucose catabolic process (GO:0019317)3.43547624
101L-fucose metabolic process (GO:0042354)3.43547624
102activation of Rac GTPase activity (GO:0032863)3.42273775
103labyrinthine layer development (GO:0060711)3.41070428
104negative regulation of digestive system process (GO:0060457)3.40750711
105negative regulation of cholesterol transport (GO:0032375)3.37288117
106negative regulation of sterol transport (GO:0032372)3.37288117
107DNA ligation (GO:0006266)3.34501029
108regulation of sister chromatid cohesion (GO:0007063)3.32635822
109termination of RNA polymerase II transcription (GO:0006369)3.30419479
110C4-dicarboxylate transport (GO:0015740)3.30383710
111regulation of response to reactive oxygen species (GO:1901031)3.30215599
112positive regulation of mitotic sister chromatid separation (GO:1901970)3.29080128
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.29080128
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.29080128
115telomere maintenance via semi-conservative replication (GO:0032201)3.27507899
116nucleotide-excision repair, DNA gap filling (GO:0006297)3.27359141
117alanine transport (GO:0032328)3.26887976
118glycerophospholipid catabolic process (GO:0046475)3.26768736
119negative regulation of mRNA processing (GO:0050686)3.26352680
120kynurenine metabolic process (GO:0070189)3.26299541
121regulation of cholesterol storage (GO:0010885)3.26118110
122aromatic amino acid family catabolic process (GO:0009074)3.24811970
123cholesterol transport (GO:0030301)3.23898456
124sterol transport (GO:0015918)3.23898456
125regulation of double-strand break repair via homologous recombination (GO:0010569)3.22830755
126cell wall macromolecule catabolic process (GO:0016998)3.22100714
127anatomical structure regression (GO:0060033)3.20634025
128trophectodermal cell differentiation (GO:0001829)3.19720227
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18941723
130histone H4-K12 acetylation (GO:0043983)3.14884114
131nucleoside transmembrane transport (GO:1901642)3.13037480
132basic amino acid transport (GO:0015802)3.12257671
133platelet dense granule organization (GO:0060155)3.10589704
134pyrimidine nucleotide catabolic process (GO:0006244)3.10521227
135response to pheromone (GO:0019236)3.10173350
136positive regulation of circadian rhythm (GO:0042753)3.09421519
137cell wall macromolecule metabolic process (GO:0044036)3.08827416
138protein targeting to vacuole (GO:0006623)3.07895332
139protein targeting to lysosome (GO:0006622)3.07895332
140establishment of protein localization to vacuole (GO:0072666)3.07895332
141regulation of cell size (GO:0008361)3.07624872
142kinetochore assembly (GO:0051382)3.07135764
143meiotic chromosome segregation (GO:0045132)3.05922353
144apoptotic process involved in morphogenesis (GO:0060561)3.03897588
145DNA demethylation (GO:0080111)3.03825557
146mRNA polyadenylation (GO:0006378)3.03283075
147protein neddylation (GO:0045116)3.03135944
148cullin deneddylation (GO:0010388)3.02540096
149L-phenylalanine catabolic process (GO:0006559)3.01046553
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.01046553
151positive regulation of prostaglandin secretion (GO:0032308)3.00750673
152lysosome organization (GO:0007040)2.99608165
153lytic vacuole organization (GO:0080171)2.99608165
154protein carboxylation (GO:0018214)2.97052719
155peptidyl-glutamic acid carboxylation (GO:0017187)2.97052719
156tryptophan metabolic process (GO:0006568)2.94633955
157protein-cofactor linkage (GO:0018065)2.94488802
158transepithelial transport (GO:0070633)2.92224322
159phospholipid efflux (GO:0033700)2.92191461
160negative regulation of fibrinolysis (GO:0051918)2.92028981
161indolalkylamine metabolic process (GO:0006586)2.89529180
162neurotransmitter-gated ion channel clustering (GO:0072578)2.87625419
163L-ascorbic acid metabolic process (GO:0019852)2.85200918
164mannosylation (GO:0097502)2.84853833
165regulation of fibrinolysis (GO:0051917)2.82421213
166detection of light stimulus involved in visual perception (GO:0050908)2.82026069
167detection of light stimulus involved in sensory perception (GO:0050962)2.82026069
168positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.75986176
169glucosamine-containing compound catabolic process (GO:1901072)2.72354877
170glycosphingolipid catabolic process (GO:0046479)2.68653766
171fucose metabolic process (GO:0006004)2.67615398
172positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.67064980
173cysteine metabolic process (GO:0006534)2.66034852
174regulation of triglyceride biosynthetic process (GO:0010866)2.64107768
175preassembly of GPI anchor in ER membrane (GO:0016254)2.63343289
176lipoprotein metabolic process (GO:0042157)2.62687522
177peptidyl-glutamic acid modification (GO:0018200)2.62427492
178ceramide catabolic process (GO:0046514)2.61648112
179respiratory chain complex IV assembly (GO:0008535)2.61577529
180renal tubule morphogenesis (GO:0061333)2.61089643
181protein polyglutamylation (GO:0018095)2.59687512
182erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58942392
183L-phenylalanine metabolic process (GO:0006558)2.58942392
184negative regulation of interleukin-1 beta production (GO:0032691)2.57070823
185intestinal absorption (GO:0050892)2.55495698
186fat-soluble vitamin biosynthetic process (GO:0042362)2.55477436
187cellular biogenic amine catabolic process (GO:0042402)2.53654545
188amine catabolic process (GO:0009310)2.53654545
189cellular anion homeostasis (GO:0030002)2.53595260
190regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53066304
191ganglioside metabolic process (GO:0001573)2.49673282
192NAD biosynthetic process (GO:0009435)2.48919832
193aromatic amino acid family metabolic process (GO:0009072)2.48631729
194cytochrome complex assembly (GO:0017004)2.45932450
195vitamin D metabolic process (GO:0042359)2.44349378
196cholesterol homeostasis (GO:0042632)2.43674638
197low-density lipoprotein particle clearance (GO:0034383)2.43170624
198proline biosynthetic process (GO:0006561)11.0895641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.39224258
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.78238524
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.66609280
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.65384053
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.49540091
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.49540091
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.49540091
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.33124985
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24792582
10ERG_21242973_ChIP-ChIP_JURKAT_Human3.03766462
11VDR_22108803_ChIP-Seq_LS180_Human3.00196528
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.97529661
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.76575791
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.76361849
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.74762484
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.70654277
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56668882
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55323512
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.51742819
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.46119223
21POU5F1_16518401_ChIP-PET_MESCs_Mouse2.45019948
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44430695
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.40536870
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.40232779
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.33654106
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.30013511
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.28931785
28TCF3_18692474_ChIP-Seq_MESCs_Mouse2.25465790
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.24026561
30VDR_21846776_ChIP-Seq_THP-1_Human2.22555483
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18794339
32LXR_22292898_ChIP-Seq_THP-1_Human2.13520590
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.13220703
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.06958306
35PU.1_20513432_ChIP-Seq_Bcells_Mouse2.06706158
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.06664634
37EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00802617
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.99409475
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98994783
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98366937
41GBX2_23144817_ChIP-Seq_PC3_Human1.95544434
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93971604
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.91086207
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88073633
45NANOG_21062744_ChIP-ChIP_HESCs_Human1.86357641
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85728907
47NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.81843957
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81660583
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81658511
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78737435
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.77495974
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.76001805
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74739128
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73582692
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72947602
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.71257879
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69679300
58IGF1R_20145208_ChIP-Seq_DFB_Human1.64333314
59NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.59089658
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56538014
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56150771
62* NANOG_19829295_ChIP-Seq_ESCs_Human1.54843843
63* SOX2_19829295_ChIP-Seq_ESCs_Human1.54843843
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.54545692
65POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.54140238
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54024491
67P300_19829295_ChIP-Seq_ESCs_Human1.53905683
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53685238
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53677794
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53099655
71TP53_22573176_ChIP-Seq_HFKS_Human1.53018332
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53009618
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.52507249
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52238014
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51806460
76ZNF263_19887448_ChIP-Seq_K562_Human1.51262034
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50869190
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.50740772
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.50466101
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50130920
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48754394
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.46294887
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43503973
84MYC_19829295_ChIP-Seq_ESCs_Human1.43503552
85NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42370879
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41749488
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41623183
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.41279300
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38762881
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36694277
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36268347
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.34637444
93RACK7_27058665_Chip-Seq_MCF-7_Human1.34231194
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.33410417
95PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.33027228
96* SPI1_26923725_Chip-Seq_HPCs_Mouse1.32917371
97AR_20517297_ChIP-Seq_VCAP_Human1.32819374
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32634915
99ETS1_21867929_ChIP-Seq_TH2_Mouse1.31945182
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30671135
101* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30657336
102VDR_23849224_ChIP-Seq_CD4+_Human1.29980144
103BCAT_22108803_ChIP-Seq_LS180_Human1.29702261
104EWS_26573619_Chip-Seq_HEK293_Human1.29582780
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28469790
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27406860
107STAT1_20625510_ChIP-Seq_HELA_Human1.25938697
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.25876038
109* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25627359
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24124510
111TAF15_26573619_Chip-Seq_HEK293_Human1.23338347
112PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22774108
113RARB_24833708_ChIP-Seq_LIVER_Mouse1.22062164
114HOXB7_26014856_ChIP-Seq_BT474_Human1.21839659
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.21146576
116MYC_18940864_ChIP-ChIP_HL60_Human1.20941507
117NANOG_16518401_ChIP-PET_MESCs_Mouse1.20553153
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20428103
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20316901
120ERA_21632823_ChIP-Seq_H3396_Human1.20188746
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20188098
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.20113326
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19405029
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18962310
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18937883
126NCOR_22424771_ChIP-Seq_293T_Human1.18783109
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.18564000
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17933222
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.17933222
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17872064
131FOXH1_21741376_ChIP-Seq_EPCs_Human1.17436549
132FOXH1_21741376_ChIP-Seq_ESCs_Human1.16568720
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.16442088
134POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16378067
135SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15489251
136OCT4_20526341_ChIP-Seq_ESCs_Human1.15019346
137RING1B_27294783_Chip-Seq_NPCs_Mouse1.14488238
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14349050
139FOXA2_19822575_ChIP-Seq_HepG2_Human1.12377793
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11542541
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11277488
142TAF2_19829295_ChIP-Seq_ESCs_Human1.10923072
143FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10891159
144SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10832978
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10824866
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10805822
147KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10526044
148SMAD4_21741376_ChIP-Seq_EPCs_Human1.09440387
149TCF4_22108803_ChIP-Seq_LS180_Human1.09319010
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09116921
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08788987
152CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08553975
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08255146
154YY1_22570637_ChIP-Seq_MALME-3M_Human1.07200049
155IRF1_19129219_ChIP-ChIP_H3396_Human1.07160187
156MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06419889
157FUS_26573619_Chip-Seq_HEK293_Human1.06175561
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05518247
159KAP1_27257070_Chip-Seq_ESCs_Mouse1.04913601
160PHF8_20622854_ChIP-Seq_HELA_Human1.04392023
161CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04384924
162E2F1_20622854_ChIP-Seq_HELA_Human1.04228892
163FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03607129
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03512845
165CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02987562
166NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02960753
167FOXP3_21729870_ChIP-Seq_TREG_Human1.02859336
168TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01735024
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01522629
170TET1_21490601_ChIP-Seq_MESCs_Mouse1.00297761
171BCOR_27268052_Chip-Seq_Bcells_Human1.00279898
172CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00227931
173KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99510920
174RAC3_21632823_ChIP-Seq_H3396_Human0.99508635
175STAT3_18555785_Chip-Seq_ESCs_Mouse0.99041275
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.98795630
177ER_23166858_ChIP-Seq_MCF-7_Human0.97748593
178* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97492632
179ETS1_20019798_ChIP-Seq_JURKAT_Human0.97372770
180POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95578947
181GATA3_26560356_Chip-Seq_TH2_Human0.95371009
182EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95187834
183SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94952237
184EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94670455
185ELK1_19687146_ChIP-ChIP_HELA_Human0.94244805
186STAT3_23295773_ChIP-Seq_U87_Human0.94025142
187CBP_20019798_ChIP-Seq_JUKART_Human0.93617331
188IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93617331
189IRF8_27001747_Chip-Seq_BMDM_Mouse0.92146907
190PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91908724
191TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91586671
192POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91586671
193SMAD3_21741376_ChIP-Seq_EPCs_Human0.90181617
194NANOG_20526341_ChIP-Seq_ESCs_Human0.89290770
195MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89203003
196EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88986037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.43120970
2MP0005171_absent_coat_pigmentation5.51590434
3MP0003195_calcinosis4.77824715
4MP0002139_abnormal_hepatobiliary_system4.71091818
5MP0009278_abnormal_bone_marrow4.14686881
6MP0002009_preneoplasia3.99790123
7MP0004233_abnormal_muscle_weight3.75380648
8MP0010030_abnormal_orbit_morphology3.58474899
9MP0005365_abnormal_bile_salt3.47020207
10MP0003122_maternal_imprinting3.11100448
11MP0008875_abnormal_xenobiotic_pharmacok3.08684072
12MP0008995_early_reproductive_senescence2.93031525
13MP0006072_abnormal_retinal_apoptosis2.68925072
14MP0005174_abnormal_tail_pigmentation2.40420399
15MP0003283_abnormal_digestive_organ2.38607941
16MP0005085_abnormal_gallbladder_physiolo2.36598557
17MP0005551_abnormal_eye_electrophysiolog2.33348195
18MP0010329_abnormal_lipoprotein_level2.28819958
19MP0002249_abnormal_larynx_morphology2.27946695
20MP0004133_heterotaxia2.23577529
21MP0003890_abnormal_embryonic-extraembry2.22000551
22MP0003011_delayed_dark_adaptation2.20532289
23MP0009840_abnormal_foam_cell2.17157637
24MP0005084_abnormal_gallbladder_morpholo2.16544989
25MP0003786_premature_aging2.12213492
26MP0005360_urolithiasis2.03799492
27MP0002282_abnormal_trachea_morphology2.03239224
28MP0008877_abnormal_DNA_methylation1.97175822
29MP0001545_abnormal_hematopoietic_system1.94642032
30MP0005397_hematopoietic_system_phenotyp1.94642032
31MP0003119_abnormal_digestive_system1.94357410
32MP0005379_endocrine/exocrine_gland_phen1.89372457
33MP0000569_abnormal_digit_pigmentation1.87302996
34MP0002653_abnormal_ependyma_morphology1.85766158
35MP0010094_abnormal_chromosome_stability1.83725067
36MP0000604_amyloidosis1.80361676
37MP0004019_abnormal_vitamin_homeostasis1.76358121
38MP0005332_abnormal_amino_acid1.74299982
39MP0000579_abnormal_nail_morphology1.68707585
40MP0005167_abnormal_blood-brain_barrier1.68112261
41MP0002938_white_spotting1.68039486
42MP0000015_abnormal_ear_pigmentation1.67895615
43MP0002837_dystrophic_cardiac_calcinosis1.67713982
44MP0003453_abnormal_keratinocyte_physiol1.66528703
45MP0001986_abnormal_taste_sensitivity1.64792442
46MP0006082_CNS_inflammation1.62845121
47MP0000462_abnormal_digestive_system1.60130964
48MP0005646_abnormal_pituitary_gland1.56156156
49MP0002254_reproductive_system_inflammat1.49076345
50MP0001293_anophthalmia1.46038327
51MP0001666_abnormal_nutrient_absorption1.43733951
52MP0005410_abnormal_fertilization1.42515692
53MP0006054_spinal_hemorrhage1.41534765
54MP0005075_abnormal_melanosome_morpholog1.41220541
55MP0003806_abnormal_nucleotide_metabolis1.38340668
56MP0009046_muscle_twitch1.37627618
57MP0002269_muscular_atrophy1.36997626
58MP0002084_abnormal_developmental_patter1.36020661
59MP0005671_abnormal_response_to1.35672820
60MP0000470_abnormal_stomach_morphology1.32646021
61MP0003941_abnormal_skin_development1.32200297
62MP0002090_abnormal_vision1.32136193
63MP0003567_abnormal_fetal_cardiomyocyte1.31779395
64MP0002876_abnormal_thyroid_physiology1.30243945
65MP0005076_abnormal_cell_differentiation1.30030200
66MP0004142_abnormal_muscle_tone1.28832311
67MP0002796_impaired_skin_barrier1.28333104
68MP0006292_abnormal_olfactory_placode1.28142839
69MP0000639_abnormal_adrenal_gland1.27410700
70MP0001340_abnormal_eyelid_morphology1.26140888
71MP0002086_abnormal_extraembryonic_tissu1.26028634
72MP0003172_abnormal_lysosome_physiology1.25487796
73MP0004957_abnormal_blastocyst_morpholog1.23352898
74MP0001984_abnormal_olfaction1.22842825
75MP0001697_abnormal_embryo_size1.22121083
76MP0003121_genomic_imprinting1.17519913
77MP0000762_abnormal_tongue_morphology1.17507291
78MP0001756_abnormal_urination1.16970358
79MP0000371_diluted_coat_color1.15490910
80MP0002085_abnormal_embryonic_tissue1.15370915
81MP0005377_hearing/vestibular/ear_phenot1.13799206
82MP0003878_abnormal_ear_physiology1.13799206
83MP0005257_abnormal_intraocular_pressure1.13554089
84MP0005310_abnormal_salivary_gland1.13118455
85MP0010386_abnormal_urinary_bladder1.12580767
86MP0003828_pulmonary_edema1.11208893
87MP0008932_abnormal_embryonic_tissue1.09321726
88MP0005645_abnormal_hypothalamus_physiol1.07508107
89MP0002102_abnormal_ear_morphology1.05864267
90MP0002148_abnormal_hypersensitivity_rea1.05669317
91MP0002229_neurodegeneration1.05323552
92MP0002638_abnormal_pupillary_reflex1.03321609
93MP0002111_abnormal_tail_morphology1.02742187
94MP0002108_abnormal_muscle_morphology1.01938324
95MP0008058_abnormal_DNA_repair1.01388239
96MP0003137_abnormal_impulse_conducting1.00935368
97MP0003755_abnormal_palate_morphology1.00311130
98MP0001764_abnormal_homeostasis1.00305465
99MP0003950_abnormal_plasma_membrane1.00273249
100MP0004197_abnormal_fetal_growth/weight/1.00048855
101MP0002138_abnormal_hepatobiliary_system0.99365446
102MP0002572_abnormal_emotion/affect_behav0.98779743
103MP0002163_abnormal_gland_morphology0.98657747
104MP0002932_abnormal_joint_morphology0.96697812
105MP0003186_abnormal_redox_activity0.96466360
106MP0002118_abnormal_lipid_homeostasis0.96229735
107MP0005195_abnormal_posterior_eye0.95950596
108MP0002114_abnormal_axial_skeleton0.95812598
109MP0005058_abnormal_lysosome_morphology0.95015577
110MP0004264_abnormal_extraembryonic_tissu0.94922342
111MP0000372_irregular_coat_pigmentation0.93754278
112MP0002693_abnormal_pancreas_physiology0.93397587
113MP0001968_abnormal_touch/_nociception0.93170887
114MP0003252_abnormal_bile_duct0.92267853
115MP0003045_fibrosis0.92243767
116MP0001324_abnormal_eye_pigmentation0.91249748
117MP0000467_abnormal_esophagus_morphology0.91207827
118MP0005253_abnormal_eye_physiology0.90969342
119MP0002332_abnormal_exercise_endurance0.90337498
120MP0003136_yellow_coat_color0.89489876
121MP0002116_abnormal_craniofacial_bone0.89417497
122MP0000490_abnormal_crypts_of0.88136729
123MP0003632_abnormal_nervous_system0.87865789
124MP0002060_abnormal_skin_morphology0.87157137
125MP0000609_abnormal_liver_physiology0.87070488
126MP0004742_abnormal_vestibular_system0.85784351
127MP0003656_abnormal_erythrocyte_physiolo0.84443606
128MP0003633_abnormal_nervous_system0.83666683
129MP0005387_immune_system_phenotype0.83537404
130MP0001790_abnormal_immune_system0.83537404
131MP0005636_abnormal_mineral_homeostasis0.82801421
132MP0000685_abnormal_immune_system0.80829496
133MP0005266_abnormal_metabolism0.79762496
134MP0000751_myopathy0.79121618
135MP0005330_cardiomyopathy0.78671722
136MP0008469_abnormal_protein_level0.78641294
137MP0003111_abnormal_nucleus_morphology0.78605244
138MP0003935_abnormal_craniofacial_develop0.78355280
139MP0003385_abnormal_body_wall0.78301745
140MP0002933_joint_inflammation0.77474450
141MP0002075_abnormal_coat/hair_pigmentati0.77275972
142MP0005508_abnormal_skeleton_morphology0.77087006
143MP0005380_embryogenesis_phenotype0.76527691
144MP0001672_abnormal_embryogenesis/_devel0.76527691
145MP0003718_maternal_effect0.75351819
146MP0008872_abnormal_physiological_respon0.74456823
147MP0002736_abnormal_nociception_after0.74412605
148MP0002419_abnormal_innate_immunity0.74376810
149MP0009764_decreased_sensitivity_to0.74376730
150MP0000778_abnormal_nervous_system0.74312689
151MP0005367_renal/urinary_system_phenotyp0.73984669
152MP0000516_abnormal_urinary_system0.73984669
153MP0002909_abnormal_adrenal_gland0.73911085
154MP0000955_abnormal_spinal_cord0.73392669
155MP0002063_abnormal_learning/memory/cond0.73355449
156MP0003879_abnormal_hair_cell0.73333795
157MP0005501_abnormal_skin_physiology0.73176463
158MP0009785_altered_susceptibility_to0.72748104
159MP0002733_abnormal_thermal_nociception0.72542384
160MP0001835_abnormal_antigen_presentation0.72098897
161MP0002557_abnormal_social/conspecific_i0.70987474
162MP0004043_abnormal_pH_regulation0.70883362
163MP0000681_abnormal_thyroid_gland0.70708664
164MP0009115_abnormal_fat_cell0.70117424
165MP0009643_abnormal_urine_homeostasis0.69527954
166MP0003631_nervous_system_phenotype0.68066155
167MP0001186_pigmentation_phenotype0.67988602
168MP0001970_abnormal_pain_threshold0.67945909
169MP0002064_seizures0.67576338
170MP0000432_abnormal_head_morphology0.66699176
171MP0003646_muscle_fatigue0.66547853
172MP0000350_abnormal_cell_proliferation0.65975763
173MP0001529_abnormal_vocalization0.65899270
174MP0000049_abnormal_middle_ear0.65351373
175MP0001145_abnormal_male_reproductive0.65168881
176MP0005408_hypopigmentation0.65032934
177MP0004885_abnormal_endolymph0.63659182
178MP0005220_abnormal_exocrine_pancreas0.63002231
179MP0005391_vision/eye_phenotype0.61591856
180MP0002080_prenatal_lethality0.59506614
181MP0010352_gastrointestinal_tract_polyps0.58458294

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.68266795
2Abnormality of liposaccharide metabolism (HP:0010968)5.67442926
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.67442926
4Abnormality of glycolipid metabolism (HP:0010969)5.67442926
5Rib fusion (HP:0000902)5.37005752
6Facial hemangioma (HP:0000329)5.20588204
7Annular pancreas (HP:0001734)5.16177299
8Pustule (HP:0200039)5.03506237
9Rectovaginal fistula (HP:0000143)4.85108397
10Rectal fistula (HP:0100590)4.85108397
11Increased IgM level (HP:0003496)4.76494882
12Alopecia of scalp (HP:0002293)4.67552305
13Vacuolated lymphocytes (HP:0001922)4.55704503
14Turricephaly (HP:0000262)4.48345490
15Poikiloderma (HP:0001029)4.41316586
16Vaginal fistula (HP:0004320)4.37981726
17Coronal craniosynostosis (HP:0004440)4.25689693
18Intestinal fistula (HP:0100819)4.24216780
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.98492806
20Ulnar bowing (HP:0003031)3.93373818
21Hypochromic microcytic anemia (HP:0004840)3.89424063
22Tongue fasciculations (HP:0001308)3.86935480
23Male infertility (HP:0003251)3.82656456
24Orthostatic hypotension (HP:0001278)3.79324206
25Short humerus (HP:0005792)3.74823010
26Aplasia/hypoplasia of the humerus (HP:0006507)3.62178779
27Increased cerebral lipofuscin (HP:0011813)3.57553604
28Congenital stationary night blindness (HP:0007642)3.56489258
29Muscle fibrillation (HP:0010546)3.53972517
30Dysautonomia (HP:0002459)3.48944583
31Intestinal atresia (HP:0011100)3.47962274
32Epidermoid cyst (HP:0200040)3.39608980
33Short chin (HP:0000331)3.38060980
34Abnormality of male internal genitalia (HP:0000022)3.35566894
35Alacrima (HP:0000522)3.35251922
36Anteriorly placed anus (HP:0001545)3.33260331
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.29510380
38Abnormal hemoglobin (HP:0011902)3.25102294
39Abnormal respiratory motile cilium morphology (HP:0005938)3.19600172
40Abnormal respiratory epithelium morphology (HP:0012253)3.19600172
41Vertebral hypoplasia (HP:0008417)3.17225096
42Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.17225096
43Prolonged partial thromboplastin time (HP:0003645)3.15821913
44Retinal atrophy (HP:0001105)3.10688377
45Xanthomatosis (HP:0000991)3.10552401
46Hypotrichosis (HP:0001006)3.09588273
47Absent radius (HP:0003974)3.09165722
48Pancreatic cysts (HP:0001737)3.08165308
49Abnormality of midbrain morphology (HP:0002418)3.06110332
50Molar tooth sign on MRI (HP:0002419)3.06110332
51Mucopolysacchariduria (HP:0008155)3.04382605
52Urinary glycosaminoglycan excretion (HP:0003541)3.04382605
53Diaphragmatic weakness (HP:0009113)3.03796600
54Clumsiness (HP:0002312)3.02510030
55Growth hormone excess (HP:0000845)2.98160535
56Volvulus (HP:0002580)2.97589601
57Abnormality of the aortic arch (HP:0012303)2.97422306
58Absent forearm bone (HP:0003953)2.93481843
59Aplasia involving forearm bones (HP:0009822)2.93481843
60True hermaphroditism (HP:0010459)2.93040822
61Congenital hip dislocation (HP:0001374)2.89521806
62Joint stiffness (HP:0001387)2.85987971
63Bulbar palsy (HP:0001283)2.82400103
643-Methylglutaconic aciduria (HP:0003535)2.79539630
65Pancreatic islet-cell hyperplasia (HP:0004510)2.78199114
66Hypokinesia (HP:0002375)2.77751909
67Dysostosis multiplex (HP:0000943)2.77166758
68Popliteal pterygium (HP:0009756)2.76889679
69Pancreatic fibrosis (HP:0100732)2.76670044
70Squamous cell carcinoma (HP:0002860)2.75302884
71Amelogenesis imperfecta (HP:0000705)2.73178206
72Absent thumb (HP:0009777)2.72055305
73Hamartoma (HP:0010566)2.71479599
74Narrow nasal bridge (HP:0000446)2.70970369
75Choanal stenosis (HP:0000452)2.70182970
76Bifid uvula (HP:0000193)2.69130163
77Capillary hemangiomas (HP:0005306)2.67786299
78Abolished electroretinogram (ERG) (HP:0000550)2.67497556
79Large for gestational age (HP:0001520)2.67134065
80Abnormality of polysaccharide metabolism (HP:0011012)2.65960267
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65960267
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65960267
83Median cleft lip (HP:0000161)2.61025861
84Broad alveolar ridges (HP:0000187)2.60271110
85Systemic lupus erythematosus (HP:0002725)2.60105497
86Aplasia of the musculature (HP:0100854)2.60005873
87Metaphyseal irregularity (HP:0003025)2.56662064
88Deep venous thrombosis (HP:0002625)2.54948904
89Hypotelorism (HP:0000601)2.51062226
90Albinism (HP:0001022)2.50248384
91Abnormality of the labia minora (HP:0012880)2.46722858
92Type 2 muscle fiber atrophy (HP:0003554)2.46690035
93Premature skin wrinkling (HP:0100678)2.46313042
94Muscle fiber atrophy (HP:0100295)2.45906158
95Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45861638
96Decreased lacrimation (HP:0000633)2.42964380
97Polydipsia (HP:0001959)2.42600630
98Abnormal drinking behavior (HP:0030082)2.42600630
99Basal cell carcinoma (HP:0002671)2.38819310
100Glomerulonephritis (HP:0000099)2.36739227
101Hypobetalipoproteinemia (HP:0003563)2.35007194
102Attenuation of retinal blood vessels (HP:0007843)2.34429448
103Selective tooth agenesis (HP:0001592)2.34127155
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32114736
105Nephronophthisis (HP:0000090)2.31489182
106Pendular nystagmus (HP:0012043)2.29716693
107Split hand (HP:0001171)2.29476625
108Atonic seizures (HP:0010819)2.28007002
109Chronic hepatic failure (HP:0100626)2.27810981
110Abnormal biliary tract physiology (HP:0012439)2.25349778
111Bile duct proliferation (HP:0001408)2.25349778
112Diminished movement (HP:0002374)2.25251768
113Acute lymphatic leukemia (HP:0006721)2.25192844
114Abnormal number of incisors (HP:0011064)2.24467989
115Hypothermia (HP:0002045)2.24127172
116Increased number of teeth (HP:0011069)2.24124239
117Infertility (HP:0000789)2.24034647
118Hypoplasia of the ulna (HP:0003022)2.22383663
119Renal cortical cysts (HP:0000803)2.21989697
120Patellar aplasia (HP:0006443)2.21211653
121Bowed forearm bones (HP:0003956)2.21152775
122Bowing of the arm (HP:0006488)2.21152775
123Joint hemorrhage (HP:0005261)2.21022548
124Tubular atrophy (HP:0000092)2.20444035
125Abnormality of the renal cortex (HP:0011035)2.19578251
126Gastrointestinal atresia (HP:0002589)2.19560566
127Hydroxyprolinuria (HP:0003080)2.19444652
128Abnormality of proline metabolism (HP:0010907)2.19444652
129Complement deficiency (HP:0004431)2.16921048
130Premature graying of hair (HP:0002216)2.15626025
131Decreased central vision (HP:0007663)2.15447084
132Abnormal rod and cone electroretinograms (HP:0008323)2.14541239
133Lipid accumulation in hepatocytes (HP:0006561)2.13282559
134Generalized aminoaciduria (HP:0002909)2.12929431
135Hypochromic anemia (HP:0001931)2.12064068
136IgA deficiency (HP:0002720)2.11579764
137Abnormal urine output (HP:0012590)2.09918009
138Redundant skin (HP:0001582)2.09165171
139Polycythemia (HP:0001901)2.04281450
140Hypophosphatemic rickets (HP:0004912)2.03630594
141Exertional dyspnea (HP:0002875)2.03536661
142Abnormality of placental membranes (HP:0011409)2.03266551
143Amniotic constriction ring (HP:0009775)2.03266551
144Polyuria (HP:0000103)2.02310709
145Hypercortisolism (HP:0001578)2.01681715
146Lower limb hyperreflexia (HP:0002395)2.00513327
147Hypercholesterolemia (HP:0003124)2.00126023
148Disinhibition (HP:0000734)2.00005270
149Aplasia/Hypoplasia of the patella (HP:0006498)1.99896464
150Vertebral fusion (HP:0002948)1.98797854
151Optic disc pallor (HP:0000543)1.96777717
152Cystic liver disease (HP:0006706)1.96404123
153Acute necrotizing encephalopathy (HP:0006965)1.95024743
154Increased hepatocellular lipid droplets (HP:0006565)1.94735927
155Increased CSF lactate (HP:0002490)1.93480552
156Abnormality of alanine metabolism (HP:0010916)1.91563541
157Hyperalaninemia (HP:0003348)1.91563541
158Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91563541
159Ketosis (HP:0001946)1.88005730
160Abnormality of the renal medulla (HP:0100957)1.83374876
161Acute encephalopathy (HP:0006846)1.83216778
162Hyperglycinuria (HP:0003108)1.82887553
163Mitochondrial inheritance (HP:0001427)1.81966656
164Hyperglycinemia (HP:0002154)1.81918519
165Medial flaring of the eyebrow (HP:0010747)1.81104948
166Poor head control (HP:0002421)1.79756851
167Abnormality of macular pigmentation (HP:0008002)1.79715367
168Myocardial infarction (HP:0001658)1.78112245
169Anophthalmia (HP:0000528)1.77393400
170Hypoplasia of the fovea (HP:0007750)1.76490314
171Aplasia/Hypoplasia of the fovea (HP:0008060)1.76490314
172Purpura (HP:0000979)1.76192668
173Mutism (HP:0002300)1.75287360
174Pigmentary retinal degeneration (HP:0001146)1.75063926
175Sclerocornea (HP:0000647)1.73918028
176Type II lissencephaly (HP:0007260)1.72523719
177Agitation (HP:0000713)1.72354175
178Supernumerary spleens (HP:0009799)1.72079611
179Enlarged kidneys (HP:0000105)1.70961410
180Increased corneal curvature (HP:0100692)1.70853739
181Keratoconus (HP:0000563)1.70853739
182Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70542584
183Mesangial abnormality (HP:0001966)1.70057003
184Abnormality of renal excretion (HP:0011036)1.66358233
185Renal Fanconi syndrome (HP:0001994)1.65894232
186Abnormality of the periventricular white matter (HP:0002518)1.65675061
187Abnormality of serine family amino acid metabolism (HP:0010894)1.64943403
188Abnormality of glycine metabolism (HP:0010895)1.64943403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.73647513
2MAPK155.58462721
3MAP3K65.45952700
4DDR24.92295664
5WNK44.65138061
6ADRBK23.74934209
7PINK13.59320190
8ZAK3.55549885
9MAP3K113.51006924
10ACVR1B3.41345836
11FGR3.37564519
12FRK3.34383305
13MAP4K23.06134353
14MATK2.96576340
15TYRO32.81475691
16DAPK12.78635597
17TLK12.68919175
18GRK12.57322212
19UHMK12.55871111
20WNK32.32540438
21PIM22.31810537
22TAOK32.26090764
23YES12.19418381
24PDGFRA2.11221886
25INSRR2.09930498
26PRKD22.08882160
27BCKDK2.08417485
28CSK2.03429759
29BMPR1B2.01842889
30DYRK1B2.01200579
31BMX1.99356727
32STK391.84272605
33AKT31.76810309
34TRPM71.76782669
35NUAK11.76354371
36STK161.65507850
37CDK71.56490785
38TGFBR21.55784397
39MAP2K61.51666616
40TXK1.42911280
41LATS21.41643153
42CAMKK21.34737051
43TIE11.20317998
44RPS6KC11.19252586
45RPS6KL11.19252586
46PHKG21.18287088
47PHKG11.18287088
48DAPK21.14522671
49IKBKB1.12519856
50CSF1R1.12452096
51GRK71.12191076
52MAPKAPK31.11093360
53OXSR11.10739686
54PRPF4B1.06535309
55GSK3A1.05667328
56PIK3CA1.03760142
57PIM11.03006878
58CASK1.02993830
59CDC42BPA1.02789528
60CDK61.02434459
61RPS6KA61.00264086
62MAP3K90.99758748
63PRKCG0.99612574
64TGFBR10.98466554
65MAPK130.93029538
66PRKCQ0.89123831
67EIF2AK30.87956677
68TNIK0.87686676
69NEK10.86770351
70CSNK1G20.86302887
71CHEK20.84040747
72MAPK110.81938230
73BRSK20.80326605
74PLK30.79574416
75MKNK20.76562410
76BLK0.76273541
77TRIM280.75926548
78ABL20.75183406
79DYRK30.73225579
80ERBB30.72517776
81VRK10.71069366
82PLK20.70965732
83CSNK1G30.70282771
84TNK20.70013493
85FGFR30.68478662
86PAK30.68123641
87NEK20.65950907
88CSNK1A1L0.65617471
89CAMK2B0.64991942
90PLK10.64711384
91FGFR10.63111423
92HIPK20.62439054
93TAOK20.61672603
94PRKCE0.61595902
95RPS6KA10.57955837
96RAF10.54789267
97PRKAA10.54263948
98CAMK2A0.54230003
99WNK10.53575907
100NME10.53466392
101CAMK2G0.52881770
102MST40.52321541
103FGFR40.52059875
104DYRK20.49132981
105PLK40.47929385
106IGF1R0.47143850
107ITK0.46873962
108PRKACA0.46297211
109MTOR0.45716686
110TYK20.45083427
111EGFR0.44688312
112RPS6KB10.44676844
113CDK80.44523376
114KIT0.42400753
115PRKACB0.41809549
116EPHA20.41748146
117CSNK2A10.40980708
118SYK0.39869581
119TSSK60.39611526
120NTRK20.39302699
121CAMK2D0.38793764
122EPHA40.38520046
123FGFR20.37838602
124ERBB20.37187081
125LYN0.36963614
126CSNK1A10.36781965
127MAPK40.36699273
128PDGFRB0.36026999
129CHUK0.35568582
130CSNK1G10.34620296
131PRKCA0.34397965
132PKN10.33910495
133LCK0.32863086
134MAPK100.32674503
135PRKG10.31520517
136MAPKAPK50.31389903
137CDK20.31367034
138CAMK1D0.30714704
139RPS6KA50.30713905
140MAPK30.30267283
141PDK30.29656752
142PDK40.29656752
143CSNK1E0.28818049
144CDK11A0.26347861
145CSNK2A20.26131421
146MAPK10.26097310
147MAP3K100.25825646
148ATR0.25767543
149SGK10.25569666
150RPS6KB20.25249841
151CDK150.24541022
152AURKA0.23814345
153MAPK140.23510831
154PRKCZ0.22951506
155CDK180.21914752
156RIPK40.21693082
157INSR0.20804738
158MAP3K120.20369786
159PRKAA20.18946795
160WEE10.16821577
161ADRBK10.16751638
162PAK60.15193913
163PAK20.15150859
164CDK10.14606417
165SIK20.14436986
166RPS6KA30.13969702
167PRKCD0.13955510
168PDK20.13787177
169MAPKAPK20.13520599
170ATM0.12533705
171PTK20.12469501
172CDK140.12410715
173GSK3B0.11477776
174PRKACG0.10628689
175MAP3K50.10580624
176CDK50.09370322
177MAP3K40.08371509

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.45019074
2Mismatch repair_Homo sapiens_hsa034304.53981039
3Base excision repair_Homo sapiens_hsa034104.52746397
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.55580274
5DNA replication_Homo sapiens_hsa030303.17337020
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.14548849
7Lysosome_Homo sapiens_hsa041422.67253071
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.66635117
9Other glycan degradation_Homo sapiens_hsa005112.41063439
10Complement and coagulation cascades_Homo sapiens_hsa046102.35122139
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.33712542
12Steroid biosynthesis_Homo sapiens_hsa001002.27281374
13Nitrogen metabolism_Homo sapiens_hsa009102.21376712
14Hedgehog signaling pathway_Homo sapiens_hsa043402.11183339
15mTOR signaling pathway_Homo sapiens_hsa041502.09351090
16Circadian rhythm_Homo sapiens_hsa047102.09011034
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07661879
18Ether lipid metabolism_Homo sapiens_hsa005652.05250584
19Primary bile acid biosynthesis_Homo sapiens_hsa001202.02726561
20Selenocompound metabolism_Homo sapiens_hsa004502.00897774
21Nucleotide excision repair_Homo sapiens_hsa034201.96907364
22Staphylococcus aureus infection_Homo sapiens_hsa051501.96550084
23Hippo signaling pathway_Homo sapiens_hsa043901.86600541
24Arginine and proline metabolism_Homo sapiens_hsa003301.86164869
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83885852
26Fat digestion and absorption_Homo sapiens_hsa049751.82376993
27Phototransduction_Homo sapiens_hsa047441.74906700
28Spliceosome_Homo sapiens_hsa030401.66135335
29RNA transport_Homo sapiens_hsa030131.65927909
30Notch signaling pathway_Homo sapiens_hsa043301.65006909
31mRNA surveillance pathway_Homo sapiens_hsa030151.61044095
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59266247
33One carbon pool by folate_Homo sapiens_hsa006701.58113926
34Tryptophan metabolism_Homo sapiens_hsa003801.52890754
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52817493
36Protein export_Homo sapiens_hsa030601.52148952
37Butanoate metabolism_Homo sapiens_hsa006501.46295589
38Adherens junction_Homo sapiens_hsa045201.42935328
39Fatty acid metabolism_Homo sapiens_hsa012121.41214926
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.40085888
41Homologous recombination_Homo sapiens_hsa034401.40008140
42p53 signaling pathway_Homo sapiens_hsa041151.39557017
43Wnt signaling pathway_Homo sapiens_hsa043101.39127478
44Rheumatoid arthritis_Homo sapiens_hsa053231.38598534
45Fanconi anemia pathway_Homo sapiens_hsa034601.37570482
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35373381
47Biosynthesis of amino acids_Homo sapiens_hsa012301.34348379
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34196026
49Sulfur relay system_Homo sapiens_hsa041221.33260162
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32576573
51Oxidative phosphorylation_Homo sapiens_hsa001901.32233131
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.30038504
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27870819
54Linoleic acid metabolism_Homo sapiens_hsa005911.27674930
55Peroxisome_Homo sapiens_hsa041461.26664720
56Oocyte meiosis_Homo sapiens_hsa041141.26383996
57Fatty acid degradation_Homo sapiens_hsa000711.25696313
58Vitamin digestion and absorption_Homo sapiens_hsa049771.25428431
59PPAR signaling pathway_Homo sapiens_hsa033201.24251951
60TGF-beta signaling pathway_Homo sapiens_hsa043501.22964146
61Folate biosynthesis_Homo sapiens_hsa007901.21481869
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19602290
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17268130
64Nicotine addiction_Homo sapiens_hsa050331.14935379
65Asthma_Homo sapiens_hsa053101.13633082
66Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12504163
67Huntingtons disease_Homo sapiens_hsa050161.08192128
68Bladder cancer_Homo sapiens_hsa052191.08000731
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07115685
70Histidine metabolism_Homo sapiens_hsa003401.05739457
71VEGF signaling pathway_Homo sapiens_hsa043701.05689161
72Parkinsons disease_Homo sapiens_hsa050121.03051845
73Type I diabetes mellitus_Homo sapiens_hsa049401.02308184
74Ribosome_Homo sapiens_hsa030101.01648537
75Basal cell carcinoma_Homo sapiens_hsa052171.01144455
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00858746
77Propanoate metabolism_Homo sapiens_hsa006400.99705472
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97516333
79Shigellosis_Homo sapiens_hsa051310.96949512
80ABC transporters_Homo sapiens_hsa020100.96048063
81Gap junction_Homo sapiens_hsa045400.95924716
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94473022
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94372419
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.91513371
85Dorso-ventral axis formation_Homo sapiens_hsa043200.90953901
86Sphingolipid metabolism_Homo sapiens_hsa006000.90636674
87Sulfur metabolism_Homo sapiens_hsa009200.87364448
88Graft-versus-host disease_Homo sapiens_hsa053320.86749361
89Regulation of autophagy_Homo sapiens_hsa041400.86024523
90Allograft rejection_Homo sapiens_hsa053300.85708165
91Antigen processing and presentation_Homo sapiens_hsa046120.85575682
92Fructose and mannose metabolism_Homo sapiens_hsa000510.85525362
93Vitamin B6 metabolism_Homo sapiens_hsa007500.84651307
94Chemical carcinogenesis_Homo sapiens_hsa052040.83086945
95Glycerolipid metabolism_Homo sapiens_hsa005610.82463927
96Cardiac muscle contraction_Homo sapiens_hsa042600.80320561
97ErbB signaling pathway_Homo sapiens_hsa040120.78971592
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77678313
99Metabolic pathways_Homo sapiens_hsa011000.76494491
100Alzheimers disease_Homo sapiens_hsa050100.75998955
101Cell cycle_Homo sapiens_hsa041100.75965410
102Caffeine metabolism_Homo sapiens_hsa002320.75952163
103Choline metabolism in cancer_Homo sapiens_hsa052310.74183657
104Autoimmune thyroid disease_Homo sapiens_hsa053200.71858521
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.70647142
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.69285599
107Retinol metabolism_Homo sapiens_hsa008300.65836001
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65451215
109Colorectal cancer_Homo sapiens_hsa052100.64687495
110Arachidonic acid metabolism_Homo sapiens_hsa005900.64138945
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63178630
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.62806938
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62438157
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61848590
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61843070
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61700512
117Amphetamine addiction_Homo sapiens_hsa050310.60685458
118Collecting duct acid secretion_Homo sapiens_hsa049660.59396219
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58787071
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57055208
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56779522
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55702322
123Lysine degradation_Homo sapiens_hsa003100.54407427
124Tight junction_Homo sapiens_hsa045300.52762540
125Glutathione metabolism_Homo sapiens_hsa004800.50141645
126Renin-angiotensin system_Homo sapiens_hsa046140.50001445
127Starch and sucrose metabolism_Homo sapiens_hsa005000.49764900
128RNA polymerase_Homo sapiens_hsa030200.48370568
129AMPK signaling pathway_Homo sapiens_hsa041520.48324600
130Insulin signaling pathway_Homo sapiens_hsa049100.48137175
131Phagosome_Homo sapiens_hsa041450.47435388
132GABAergic synapse_Homo sapiens_hsa047270.45690561
133Proteasome_Homo sapiens_hsa030500.42713981
134GnRH signaling pathway_Homo sapiens_hsa049120.41400630
135beta-Alanine metabolism_Homo sapiens_hsa004100.41052173
136MAPK signaling pathway_Homo sapiens_hsa040100.39889290
137Long-term depression_Homo sapiens_hsa047300.38343011
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37481814
139Primary immunodeficiency_Homo sapiens_hsa053400.37420873
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.37412939
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36539850
142Viral myocarditis_Homo sapiens_hsa054160.36477052
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34916321
144Mineral absorption_Homo sapiens_hsa049780.34846842
145MicroRNAs in cancer_Homo sapiens_hsa052060.34704269
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32160325
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32025240
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30871548
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30678908
150Arginine biosynthesis_Homo sapiens_hsa002200.30108333
151Galactose metabolism_Homo sapiens_hsa000520.29730989
152Estrogen signaling pathway_Homo sapiens_hsa049150.28201142
153Legionellosis_Homo sapiens_hsa051340.27733683
154Fatty acid elongation_Homo sapiens_hsa000620.27632541
155Synaptic vesicle cycle_Homo sapiens_hsa047210.27422930
156Acute myeloid leukemia_Homo sapiens_hsa052210.25690715
157Olfactory transduction_Homo sapiens_hsa047400.24812651
158Cyanoamino acid metabolism_Homo sapiens_hsa004600.21142530
159Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19238652
160Long-term potentiation_Homo sapiens_hsa047200.18903125
161Basal transcription factors_Homo sapiens_hsa030220.17702040
162Glucagon signaling pathway_Homo sapiens_hsa049220.17639178
163Melanogenesis_Homo sapiens_hsa049160.17439990
164Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17065031
165Taste transduction_Homo sapiens_hsa047420.14820832
166Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14712823
167Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14433583
168Dopaminergic synapse_Homo sapiens_hsa047280.11450409

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