RAB43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.68798331
2L-phenylalanine catabolic process (GO:0006559)6.68798331
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.40741975
4L-phenylalanine metabolic process (GO:0006558)6.40741975
5aromatic amino acid family catabolic process (GO:0009074)6.15811961
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.09681952
7indole-containing compound catabolic process (GO:0042436)5.65957692
8indolalkylamine catabolic process (GO:0046218)5.65957692
9tryptophan catabolic process (GO:0006569)5.65957692
10kynurenine metabolic process (GO:0070189)5.59730083
11alpha-linolenic acid metabolic process (GO:0036109)5.41906283
12tryptophan metabolic process (GO:0006568)5.35457764
13negative regulation of cell killing (GO:0031342)5.34586734
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.34586734
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33416009
16bile acid biosynthetic process (GO:0006699)5.31970144
17urea cycle (GO:0000050)5.29779378
18urea metabolic process (GO:0019627)5.29779378
19high-density lipoprotein particle remodeling (GO:0034375)5.25213087
20negative regulation of fibrinolysis (GO:0051918)5.21576250
21protein carboxylation (GO:0018214)5.12196059
22peptidyl-glutamic acid carboxylation (GO:0017187)5.12196059
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.09263099
24glyoxylate metabolic process (GO:0046487)5.06410384
25complement activation, alternative pathway (GO:0006957)5.02155505
26cysteine metabolic process (GO:0006534)4.99463116
27antigen processing and presentation of endogenous antigen (GO:0019883)4.98103727
28sulfur amino acid catabolic process (GO:0000098)4.96433557
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.93360271
30regulation of fibrinolysis (GO:0051917)4.92328362
31nitrogen cycle metabolic process (GO:0071941)4.85701121
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84653830
33regulation of protein activation cascade (GO:2000257)4.84520294
34regulation of triglyceride catabolic process (GO:0010896)4.64963651
35reverse cholesterol transport (GO:0043691)4.64807891
36regulation of cholesterol esterification (GO:0010872)4.63922620
37bile acid metabolic process (GO:0008206)4.62957441
38positive regulation of gamma-delta T cell activation (GO:0046645)4.60541762
39phospholipid efflux (GO:0033700)4.58695942
40regulation of complement activation (GO:0030449)4.54573330
41serine family amino acid catabolic process (GO:0009071)4.52773927
42positive regulation by symbiont of host defense response (GO:0052509)4.51291333
43modulation by symbiont of host defense response (GO:0052031)4.51291333
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.51291333
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.51291333
46positive regulation by organism of defense response of other organism involved in symbiotic interact4.51291333
47modulation by symbiont of host immune response (GO:0052553)4.51291333
48negative regulation of cholesterol transport (GO:0032375)4.50639596
49negative regulation of sterol transport (GO:0032372)4.50639596
50protein-lipid complex remodeling (GO:0034368)4.48987160
51macromolecular complex remodeling (GO:0034367)4.48987160
52plasma lipoprotein particle remodeling (GO:0034369)4.48987160
53aromatic amino acid family metabolic process (GO:0009072)4.42579440
54homocysteine metabolic process (GO:0050667)4.40097113
55plasma lipoprotein particle clearance (GO:0034381)4.31953077
56amino-acid betaine metabolic process (GO:0006577)4.31837625
57lysine metabolic process (GO:0006553)4.29770981
58lysine catabolic process (GO:0006554)4.29770981
59tyrosine metabolic process (GO:0006570)4.28608318
60detection of other organism (GO:0098543)4.27515337
61acylglycerol homeostasis (GO:0055090)4.22469137
62triglyceride homeostasis (GO:0070328)4.22469137
63detection of bacterium (GO:0016045)4.21460159
64cholesterol efflux (GO:0033344)4.13475525
65bile acid and bile salt transport (GO:0015721)4.11820411
66plasma lipoprotein particle assembly (GO:0034377)4.09650246
67alpha-amino acid catabolic process (GO:1901606)4.07710694
68cellular ketone body metabolic process (GO:0046950)3.97863353
69leukocyte aggregation (GO:0070486)3.95499037
70indolalkylamine metabolic process (GO:0006586)3.95482997
71cellular glucuronidation (GO:0052695)3.88613365
72macrophage activation involved in immune response (GO:0002281)3.85444157
73positive regulation of lipoprotein lipase activity (GO:0051006)3.84127318
74positive regulation of triglyceride lipase activity (GO:0061365)3.84127318
75amine catabolic process (GO:0009310)3.83222016
76cellular biogenic amine catabolic process (GO:0042402)3.83222016
77phospholipid homeostasis (GO:0055091)3.82679354
78regulation of cholesterol homeostasis (GO:2000188)3.80675037
79glycine metabolic process (GO:0006544)3.80250856
80positive regulation of lipid catabolic process (GO:0050996)3.78871358
81benzene-containing compound metabolic process (GO:0042537)3.78788025
82ethanol oxidation (GO:0006069)3.77927586
83protein-lipid complex assembly (GO:0065005)3.77172984
84fibrinolysis (GO:0042730)3.76050220
85glutamate metabolic process (GO:0006536)3.75497684
86dicarboxylic acid biosynthetic process (GO:0043650)3.74633545
87cellular amino acid catabolic process (GO:0009063)3.73974405
88cellular modified amino acid catabolic process (GO:0042219)3.72978836
89imidazole-containing compound metabolic process (GO:0052803)3.71501539
90low-density lipoprotein particle remodeling (GO:0034374)3.71256226
91detection of external biotic stimulus (GO:0098581)3.69786347
92drug catabolic process (GO:0042737)3.66836869
93response to interleukin-15 (GO:0070672)3.66227892
94coenzyme catabolic process (GO:0009109)3.65442623
95regulation of gamma-delta T cell activation (GO:0046643)3.64816420
96very-low-density lipoprotein particle assembly (GO:0034379)3.64633990
97serine family amino acid metabolic process (GO:0009069)3.63037727
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62716233
99response to peptidoglycan (GO:0032494)3.61632716
100cholesterol homeostasis (GO:0042632)3.60577967
101plasma lipoprotein particle organization (GO:0071827)3.60251245
102arginine metabolic process (GO:0006525)3.55419820
103sterol homeostasis (GO:0055092)3.55242951
104complement activation, classical pathway (GO:0006958)3.54960377
105complement activation (GO:0006956)3.54157297
106negative regulation of erythrocyte differentiation (GO:0045647)3.52889041
107protein activation cascade (GO:0072376)3.50014098
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.49997324
109cofactor catabolic process (GO:0051187)3.47469337
110positive regulation of fatty acid beta-oxidation (GO:0032000)3.47434516
111negative regulation of lipase activity (GO:0060192)3.46989042
112aldehyde catabolic process (GO:0046185)3.46833363
113blood coagulation, intrinsic pathway (GO:0007597)3.46654899
114intestinal cholesterol absorption (GO:0030299)3.44621289
115uronic acid metabolic process (GO:0006063)3.44595771
116glucuronate metabolic process (GO:0019585)3.44595771
117protein-lipid complex subunit organization (GO:0071825)3.44580512
118negative regulation of lymphocyte mediated immunity (GO:0002707)3.43472206
119detection of molecule of bacterial origin (GO:0032490)3.43434866
120ketone body metabolic process (GO:1902224)3.43277593
121flavonoid metabolic process (GO:0009812)3.42215363
122neutrophil activation involved in immune response (GO:0002283)3.41011410
123acute-phase response (GO:0006953)3.40046812
124cellular extravasation (GO:0045123)3.39720256
125lipoprotein metabolic process (GO:0042157)3.39418975
126regulation of interferon-beta biosynthetic process (GO:0045357)3.38842194
127negative regulation of interleukin-12 production (GO:0032695)3.37544845
128regulation of B cell receptor signaling pathway (GO:0050855)3.37342969
129regulation of gamma-delta T cell differentiation (GO:0045586)3.35920282
130tolerance induction (GO:0002507)3.35772969
131pyridine nucleotide biosynthetic process (GO:0019363)3.34706818
132nicotinamide nucleotide biosynthetic process (GO:0019359)3.34706818
133serine family amino acid biosynthetic process (GO:0009070)3.34561256
134detection of biotic stimulus (GO:0009595)3.30487347
135response to type I interferon (GO:0034340)3.30053781
136cellular response to type I interferon (GO:0071357)3.28479124
137type I interferon signaling pathway (GO:0060337)3.28479124
138regulation of T cell tolerance induction (GO:0002664)3.28294965
139positive thymic T cell selection (GO:0045059)3.28161231
140negative thymic T cell selection (GO:0045060)3.26373817
141thymic T cell selection (GO:0045061)3.25225438
142cellular response to interleukin-15 (GO:0071350)3.18026944
143negative regulation of leukocyte mediated immunity (GO:0002704)3.16329783
144negative T cell selection (GO:0043383)3.13767302
145response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04640769
146response to host immune response (GO:0052572)3.04640769
147T cell selection (GO:0045058)3.03540918
148germinal center formation (GO:0002467)3.01686672
149NIK/NF-kappaB signaling (GO:0038061)3.00757256
150response to host (GO:0075136)3.00508653
151response to host defenses (GO:0052200)3.00508653
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00508653
153response to muramyl dipeptide (GO:0032495)2.98686187
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96307764
155leukocyte migration involved in inflammatory response (GO:0002523)2.92147323
156regulation of tolerance induction (GO:0002643)2.91803647
157regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90816904
158regulation of T-helper 2 cell differentiation (GO:0045628)2.89019917
159immunoglobulin mediated immune response (GO:0016064)2.88156316
160negative regulation of T cell mediated immunity (GO:0002710)2.84004698
161antigen processing and presentation via MHC class Ib (GO:0002475)2.83835443
162respiratory burst (GO:0045730)2.83058910
163response to laminar fluid shear stress (GO:0034616)2.81488610
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80759943
165production of molecular mediator involved in inflammatory response (GO:0002532)2.79974139
166negative regulation of cytokine production involved in immune response (GO:0002719)2.78939609
167negative regulation of phagocytosis (GO:0050765)2.77565443
168negative regulation of innate immune response (GO:0045824)2.73888931
169positive T cell selection (GO:0043368)2.73787113
170mannose metabolic process (GO:0006013)2.72762981
171B cell receptor signaling pathway (GO:0050853)2.71686415
172regulation of mast cell degranulation (GO:0043304)2.70357609
173neutrophil activation (GO:0042119)2.70263772
174lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69725522
175positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69240148
176regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68683824
177positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68374275
178regulation of T cell mediated cytotoxicity (GO:0001914)2.67851025
179myeloid cell activation involved in immune response (GO:0002275)2.66877508
180defense response to protozoan (GO:0042832)2.65016979
181regulation of leukocyte degranulation (GO:0043300)2.62114192
182negative regulation of T-helper cell differentiation (GO:0045623)2.61736878
183negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.61736878
184positive regulation of tolerance induction (GO:0002645)2.60662069
185regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58327764
186myeloid dendritic cell differentiation (GO:0043011)2.58182087
187macrophage activation (GO:0042116)2.57627932
188T cell migration (GO:0072678)2.57254498
189granulocyte activation (GO:0036230)2.56739767
190negative regulation of type 2 immune response (GO:0002829)2.56081752
191regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55290978
192regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.55074913
193regulation of natural killer cell mediated immunity (GO:0002715)2.55074913
194negative regulation of interleukin-6 production (GO:0032715)2.53093902
195negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52782359
196regulation of B cell differentiation (GO:0045577)2.52365888
197negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50671968
198protein localization to endosome (GO:0036010)2.47112131
199regulation of extracellular matrix disassembly (GO:0010715)2.46798452
200response to protozoan (GO:0001562)2.46539320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.31090936
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.40930795
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.83930590
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.72306021
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.45436101
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.28908760
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.28242310
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.43898692
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.29206800
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.85016784
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64051086
12GATA1_22025678_ChIP-Seq_K562_Human2.26715449
13KDM2B_26808549_Chip-Seq_DND41_Human2.23381582
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22428835
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20273003
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08441555
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03452407
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00175539
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1867915
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90349825
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85026416
22SPI1_23127762_ChIP-Seq_K562_Human1.78393462
23* MAF_26560356_Chip-Seq_TH2_Human1.77293381
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.76010322
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73014044
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71358266
27CLOCK_20551151_ChIP-Seq_293T_Human1.69534404
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.63193322
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.58552448
30SPI1_23547873_ChIP-Seq_NB4_Human1.56970065
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.54805994
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50516084
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50358227
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48584726
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48224813
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.47707546
37KDM2B_26808549_Chip-Seq_K562_Human1.47544883
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47359136
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.47272446
40* MYB_26560356_Chip-Seq_TH2_Human1.46553229
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46348668
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43919633
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35672082
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34559448
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31930151
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.30485123
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29244329
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27248384
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25838319
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24869986
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24065537
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.23484498
53P68_20966046_ChIP-Seq_HELA_Human1.22798872
54BCOR_27268052_Chip-Seq_Bcells_Human1.22521276
55BCL6_27268052_Chip-Seq_Bcells_Human1.21522006
56SMC4_20622854_ChIP-Seq_HELA_Human1.20465086
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16601693
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16163571
59SCL_19346495_ChIP-Seq_HPC-7_Human1.15640637
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15620919
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11361333
62* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10571428
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09673849
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.09115170
65GATA3_27048872_Chip-Seq_THYMUS_Human1.07252572
66GATA1_19941826_ChIP-Seq_K562_Human1.07215840
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06833082
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06739657
69NCOR1_26117541_ChIP-Seq_K562_Human1.05806863
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05406152
71* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04952464
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01931162
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.01475592
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.01392820
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00467025
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00137124
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99680642
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99386955
79* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99294537
80VDR_24787735_ChIP-Seq_THP-1_Human0.97366329
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97162544
82LXR_22292898_ChIP-Seq_THP-1_Human0.96964197
83GATA4_25053715_ChIP-Seq_YYC3_Human0.96140172
84DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92849741
85GATA2_19941826_ChIP-Seq_K562_Human0.92576225
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91718040
87* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91639161
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90861879
89* MAF_26560356_Chip-Seq_TH1_Human0.88477398
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88027603
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86265235
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85724017
93RUNX_20019798_ChIP-Seq_JUKART_Human0.82067568
94TCF7_22412390_ChIP-Seq_EML_Mouse0.79866130
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79062320
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78300339
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78115536
98HTT_18923047_ChIP-ChIP_STHdh_Human0.77696654
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.77232167
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76331569
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.75535733
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75116081
103* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74698753
104MYC_22102868_ChIP-Seq_BL_Human0.74504527
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73349745
106VDR_21846776_ChIP-Seq_THP-1_Human0.73087944
107* MYB_26560356_Chip-Seq_TH1_Human0.72391018
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.71611710
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71114934
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70732233
111* FOXO3_23340844_ChIP-Seq_DLD1_Human0.70566284
112EGR1_19032775_ChIP-ChIP_M12_Human0.70072720
113ZNF263_19887448_ChIP-Seq_K562_Human0.69965279
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69819223
115* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69254746
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69181227
117* GATA6_25053715_ChIP-Seq_YYC3_Human0.69147513
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.69049121
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.68683861
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.68125382
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.65764326
122PU_27001747_Chip-Seq_BMDM_Mouse0.65222698
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65200561
124STAT4_19710469_ChIP-ChIP_TH1__Mouse0.65153952
125* RARA_24833708_ChIP-Seq_LIVER_Mouse0.65043530
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.64273493
127RUNX1_22412390_ChIP-Seq_EML_Mouse0.63235600
128RACK7_27058665_Chip-Seq_MCF-7_Human0.63232535
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62673382
130* UTX_26944678_Chip-Seq_JUKART_Human0.62668559
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.62273770
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61918165
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61647551
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.61393647
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.61334469
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.61306689
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.61258225
138VDR_24763502_ChIP-Seq_THP-1_Human0.61132108
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60772601
140CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.59334069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.41080665
2MP0005360_urolithiasis6.66409633
3MP0005085_abnormal_gallbladder_physiolo5.53475763
4MP0005365_abnormal_bile_salt5.40608284
5MP0008875_abnormal_xenobiotic_pharmacok4.55241321
6MP0003252_abnormal_bile_duct3.60025731
7MP0009840_abnormal_foam_cell3.45649979
8MP0003806_abnormal_nucleotide_metabolis3.27036388
9MP0010329_abnormal_lipoprotein_level3.24285370
10MP0005083_abnormal_biliary_tract3.00103737
11MP0003191_abnormal_cellular_cholesterol2.66639924
12MP0003763_abnormal_thymus_physiology2.54931749
13MP0001666_abnormal_nutrient_absorption2.48973152
14MP0005332_abnormal_amino_acid2.35900265
15MP0002138_abnormal_hepatobiliary_system2.33252293
16MP0000609_abnormal_liver_physiology2.17255537
17MP0003195_calcinosis2.15122475
18MP0008260_abnormal_autophagy2.09604248
19MP0002118_abnormal_lipid_homeostasis1.90060013
20MP0004019_abnormal_vitamin_homeostasis1.85876847
21MP0009333_abnormal_splenocyte_physiolog1.82728539
22MP0003656_abnormal_erythrocyte_physiolo1.78611213
23MP0002148_abnormal_hypersensitivity_rea1.76630106
24MP0003172_abnormal_lysosome_physiology1.75269734
25MP0002405_respiratory_system_inflammati1.74770010
26MP0005319_abnormal_enzyme/_coenzyme1.74639916
27MP0002132_abnormal_respiratory_system1.66362369
28MP0003868_abnormal_feces_composition1.63808236
29MP0000858_altered_metastatic_potential1.62570359
30MP0000716_abnormal_immune_system1.59510691
31MP0002398_abnormal_bone_marrow1.57509187
32MP0009278_abnormal_bone_marrow1.52394518
33MP0005584_abnormal_enzyme/coenzyme_acti1.49536079
34MP0003828_pulmonary_edema1.46938078
35MP0002998_abnormal_bone_remodeling1.46446754
36MP0003866_abnormal_defecation1.45450181
37MP0003705_abnormal_hypodermis_morpholog1.44971672
38MP0004381_abnormal_hair_follicle1.43914275
39MP0003436_decreased_susceptibility_to1.43579526
40MP0004858_abnormal_nervous_system1.40275854
41MP0001764_abnormal_homeostasis1.39956646
42MP0002933_joint_inflammation1.32811837
43MP0009764_decreased_sensitivity_to1.30702580
44MP0009643_abnormal_urine_homeostasis1.30439921
45MP0001835_abnormal_antigen_presentation1.30106477
46MP0005451_abnormal_body_composition1.29606339
47MP0002722_abnormal_immune_system1.28573480
48MP0003566_abnormal_cell_adhesion1.27972001
49MP0000598_abnormal_liver_morphology1.27123121
50MP0000465_gastrointestinal_hemorrhage1.26868482
51MP0000703_abnormal_thymus_morphology1.26672933
52MP0002429_abnormal_blood_cell1.26191980
53MP0001849_ear_inflammation1.24376456
54MP0000604_amyloidosis1.23323659
55MP0008469_abnormal_protein_level1.23054006
56MP0001851_eye_inflammation1.21143512
57MP0005464_abnormal_platelet_physiology1.20372780
58MP0003279_aneurysm1.20219196
59MP0005310_abnormal_salivary_gland1.20199794
60MP0002254_reproductive_system_inflammat1.18174577
61MP0003186_abnormal_redox_activity1.16950981
62MP0005076_abnormal_cell_differentiation1.16559872
63MP0009763_increased_sensitivity_to1.15328743
64MP0003091_abnormal_cell_migration1.15207696
65MP0002396_abnormal_hematopoietic_system1.15186546
66MP0003300_gastrointestinal_ulcer1.12506570
67MP0003303_peritoneal_inflammation1.11138226
68MP0008004_abnormal_stomach_pH1.10898535
69MP0003045_fibrosis1.10204254
70MP0000685_abnormal_immune_system1.10183758
71MP0005164_abnormal_response_to1.10028121
72MP0003011_delayed_dark_adaptation1.05537513
73MP0009697_abnormal_copulation1.04583764
74MP0006082_CNS_inflammation1.00352580
75MP0001663_abnormal_digestive_system1.00079513
76MP0005390_skeleton_phenotype0.99796704
77MP0000767_abnormal_smooth_muscle0.98905340
78MP0000490_abnormal_crypts_of0.93040222
79MP0009785_altered_susceptibility_to0.92059473
80MP0005636_abnormal_mineral_homeostasis0.91827295
81MP0003724_increased_susceptibility_to0.90421500
82MP0005058_abnormal_lysosome_morphology0.90350531
83MP0002419_abnormal_innate_immunity0.90218991
84MP0005025_abnormal_response_to0.89552730
85MP0005647_abnormal_sex_gland0.89090008
86MP0001853_heart_inflammation0.88717996
87MP0009642_abnormal_blood_homeostasis0.88633489
88MP0001790_abnormal_immune_system0.88448499
89MP0005387_immune_system_phenotype0.88448499
90MP0003448_altered_tumor_morphology0.86430659
91MP0003183_abnormal_peptide_metabolism0.85458389
92MP0001845_abnormal_inflammatory_respons0.85289233
93MP0001800_abnormal_humoral_immune0.84864901
94MP0001545_abnormal_hematopoietic_system0.83731269
95MP0005397_hematopoietic_system_phenotyp0.83731269
96MP0009765_abnormal_xenobiotic_induced0.81918234
97MP0001958_emphysema0.80615229
98MP0010368_abnormal_lymphatic_system0.80415912
99MP0004947_skin_inflammation0.79958472
100MP0002277_abnormal_respiratory_mucosa0.78867065
101MP0002166_altered_tumor_susceptibility0.73953159
102MP0005408_hypopigmentation0.72462534
103MP0005334_abnormal_fat_pad0.72211872
104MP0002136_abnormal_kidney_physiology0.71356774
105MP0005084_abnormal_gallbladder_morpholo0.71237709
106MP0004130_abnormal_muscle_cell0.70753098
107MP0003075_altered_response_to0.70582784
108MP0002928_abnormal_bile_duct0.69703275
109MP0003795_abnormal_bone_structure0.69339629
110MP0001915_intracranial_hemorrhage0.68908372
111MP0005381_digestive/alimentary_phenotyp0.68684177
112MP0002078_abnormal_glucose_homeostasis0.68412039
113MP0000343_altered_response_to0.68382959
114MP0005376_homeostasis/metabolism_phenot0.67355315
115MP0010155_abnormal_intestine_physiology0.67045150
116MP0003690_abnormal_glial_cell0.66844731
117MP0005166_decreased_susceptibility_to0.66685740
118MP0002971_abnormal_brown_adipose0.66462681
119MP0005167_abnormal_blood-brain_barrier0.66375187
120MP0004808_abnormal_hematopoietic_stem0.65999944
121MP0001756_abnormal_urination0.65905808
122MP0005220_abnormal_exocrine_pancreas0.65200302
123MP0002452_abnormal_antigen_presenting0.64502650
124MP0002723_abnormal_immune_serum0.64017489
125MP0001533_abnormal_skeleton_physiology0.63602474
126MP0005670_abnormal_white_adipose0.63472773
127MP0005000_abnormal_immune_tolerance0.62711018
128MP0008873_increased_physiological_sensi0.57067450
129MP0000249_abnormal_blood_vessel0.56556120
130MP0005535_abnormal_body_temperature0.54670839
131MP0006036_abnormal_mitochondrial_physio0.54527189
132MP0003638_abnormal_response/metabolism_0.53111041
133MP0002876_abnormal_thyroid_physiology0.52233754
134MP0004510_myositis0.50693142
135MP0005671_abnormal_response_to0.50470609
136MP0005448_abnormal_energy_balance0.49951646
137MP0000689_abnormal_spleen_morphology0.49559145
138MP0001661_extended_life_span0.49517290
139MP0003329_amyloid_beta_deposits0.48721693
140MP0001873_stomach_inflammation0.47776588
141MP0008874_decreased_physiological_sensi0.47691223
142MP0004883_abnormal_blood_vessel0.45607311
143MP0001819_abnormal_immune_cell0.45305697
144MP0001243_abnormal_dermal_layer0.45305096
145MP0003453_abnormal_keratinocyte_physiol0.45252906
146MP0009115_abnormal_fat_cell0.45098570
147MP0002420_abnormal_adaptive_immunity0.44695142
148MP0005023_abnormal_wound_healing0.44147335

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.90679564
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.45901024
3Intrahepatic cholestasis (HP:0001406)6.28062642
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.95598820
5Xanthomatosis (HP:0000991)5.81264708
6Prolonged partial thromboplastin time (HP:0003645)5.68408021
7Hypobetalipoproteinemia (HP:0003563)5.63381664
8Eczematoid dermatitis (HP:0000976)5.60366697
9Complement deficiency (HP:0004431)5.02736360
10Hyperlipoproteinemia (HP:0010980)5.01541772
11Joint hemorrhage (HP:0005261)4.62684011
12Myositis (HP:0100614)4.53211296
13Orchitis (HP:0100796)4.32481450
14Abnormality of macrophages (HP:0004311)4.23636979
15Abnormality of the common coagulation pathway (HP:0010990)4.23539756
16Hypolipoproteinemia (HP:0010981)4.23122837
17Recurrent abscess formation (HP:0002722)4.16054478
18Epidermoid cyst (HP:0200040)4.04039864
19Hyperammonemia (HP:0001987)4.00144294
20Recurrent bacterial skin infections (HP:0005406)3.99854341
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.97072192
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.91818955
23Retrobulbar optic neuritis (HP:0100654)3.88037298
24Optic neuritis (HP:0100653)3.88037298
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.85482924
26Abnormality of complement system (HP:0005339)3.84594350
27Hypoalphalipoproteinemia (HP:0003233)3.74141346
28Fat malabsorption (HP:0002630)3.71306079
29Ketosis (HP:0001946)3.68968252
30Hypercholesterolemia (HP:0003124)3.57181301
31Abnormality of methionine metabolism (HP:0010901)3.54757568
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.52903933
33Myocardial infarction (HP:0001658)3.50607960
34Hyperglycinemia (HP:0002154)3.47834735
35Elevated erythrocyte sedimentation rate (HP:0003565)3.43712017
36Abnormality of the intrinsic pathway (HP:0010989)3.41131291
37Gastrointestinal infarctions (HP:0005244)3.40307299
38Stomatitis (HP:0010280)3.39696448
39Systemic lupus erythematosus (HP:0002725)3.37612805
40Abnormality of pyrimidine metabolism (HP:0004353)3.36059691
41Hypoglycemic coma (HP:0001325)3.35000095
42Hyperglycinuria (HP:0003108)3.25201971
43Hyperbilirubinemia (HP:0002904)3.23084651
44Conjugated hyperbilirubinemia (HP:0002908)3.21203154
45Abnormality of glycine metabolism (HP:0010895)3.19556979
46Abnormality of serine family amino acid metabolism (HP:0010894)3.19556979
47Meningitis (HP:0001287)3.17981612
48Spontaneous hematomas (HP:0007420)3.17264737
49Recurrent fungal infections (HP:0002841)3.17236995
50Recurrent gram-negative bacterial infections (HP:0005420)3.16421691
51Mediastinal lymphadenopathy (HP:0100721)3.13575535
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09409559
53Gingivitis (HP:0000230)3.06904291
54Abnormality of fatty-acid metabolism (HP:0004359)3.02749557
55Chronic obstructive pulmonary disease (HP:0006510)3.02668378
56Obstructive lung disease (HP:0006536)3.02668378
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.97346491
58Increased IgE level (HP:0003212)2.93218531
59Hepatocellular carcinoma (HP:0001402)2.92588548
60Cellulitis (HP:0100658)2.90206966
61Acanthocytosis (HP:0001927)2.89537950
62Pustule (HP:0200039)2.89095456
63Hypochromic microcytic anemia (HP:0004840)2.88837104
64Abnormality of nucleobase metabolism (HP:0010932)2.88792931
65Glomerulonephritis (HP:0000099)2.84814502
66Vasculitis (HP:0002633)2.82636410
67Mitral stenosis (HP:0001718)2.81542875
68Keratoconjunctivitis sicca (HP:0001097)2.78318533
69Steatorrhea (HP:0002570)2.77034326
70Gingival bleeding (HP:0000225)2.74070273
71Recurrent skin infections (HP:0001581)2.73400119
72Abnormality of purine metabolism (HP:0004352)2.65159551
73Spontaneous abortion (HP:0005268)2.62926077
74Poikilocytosis (HP:0004447)2.62386437
75Prolonged bleeding time (HP:0003010)2.61805731
76Skin nodule (HP:0200036)2.60751678
77Pulmonary infiltrates (HP:0002113)2.59408299
78Dysostosis multiplex (HP:0000943)2.57258275
79Delayed CNS myelination (HP:0002188)2.56683472
80Hypochromic anemia (HP:0001931)2.53986075
81Ketoacidosis (HP:0001993)2.53727534
82Keratoconjunctivitis (HP:0001096)2.51581026
83Encephalitis (HP:0002383)2.48431902
84Vascular calcification (HP:0004934)2.46030935
85Menorrhagia (HP:0000132)2.45816351
86Esophageal varix (HP:0002040)2.45387098
87Hemoptysis (HP:0002105)2.44864817
88Gastrointestinal inflammation (HP:0004386)2.42682623
89Cholelithiasis (HP:0001081)2.41369317
90Urinary glycosaminoglycan excretion (HP:0003541)2.41107633
91Mucopolysacchariduria (HP:0008155)2.41107633
92Purpura (HP:0000979)2.40437518
93T lymphocytopenia (HP:0005403)2.39835049
94Metabolic acidosis (HP:0001942)2.39398371
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39113542
96Abnormality of polysaccharide metabolism (HP:0011012)2.39113542
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39113542
98Abnormal gallbladder morphology (HP:0012437)2.39052052
99Chest pain (HP:0100749)2.37271630
100Chronic mucocutaneous candidiasis (HP:0002728)2.36700785
101Recurrent cutaneous fungal infections (HP:0011370)2.36700785
102Amyloidosis (HP:0011034)2.36568640
103Inflammation of the large intestine (HP:0002037)2.36440076
104Spastic diplegia (HP:0001264)2.31311908
105Colitis (HP:0002583)2.31190121
106Recurrent viral infections (HP:0004429)2.30627660
107Abnormality of serum amino acid levels (HP:0003112)2.30362942
108Thrombophlebitis (HP:0004418)2.29291808
109Hemorrhage of the eye (HP:0011885)2.28614961
110Urticaria (HP:0001025)2.27590124
111Panhypogammaglobulinemia (HP:0003139)2.23615440
112Obstructive sleep apnea (HP:0002870)2.22784190
113Abnormality of T cell number (HP:0011839)2.22717150
114Cardiovascular calcification (HP:0011915)2.22452552
115Abnormality of the fingertips (HP:0001211)2.21511244
116Abnormality of iron homeostasis (HP:0011031)2.21419682
117Arterial thrombosis (HP:0004420)2.20861657
118Malnutrition (HP:0004395)2.20810487
119Anorexia (HP:0002039)2.19334513
120Gout (HP:0001997)2.18601612
121Polygenic inheritance (HP:0010982)2.16802629
122Autoimmune thrombocytopenia (HP:0001973)2.15003797
123Abnormality of transition element cation homeostasis (HP:0011030)2.14918944
124Nephritis (HP:0000123)2.14845777
125Cholecystitis (HP:0001082)2.13336701
126Abnormal gallbladder physiology (HP:0012438)2.13336701
127Hypoglycemic seizures (HP:0002173)2.11124210
128Dicarboxylic aciduria (HP:0003215)2.11023521
129Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11023521
130Increased IgM level (HP:0003496)2.10851992
131Sensorimotor neuropathy (HP:0007141)2.10479806
132Reticulocytosis (HP:0001923)2.09511787
133Emphysema (HP:0002097)2.09423159
134Pancreatitis (HP:0001733)2.09146510
135Late onset (HP:0003584)2.07873588
136Polycythemia (HP:0001901)2.07835727
137Interstitial pulmonary disease (HP:0006530)2.07136409
138Pulmonary embolism (HP:0002204)2.06192088
139Hydroxyprolinuria (HP:0003080)2.05770805
140Abnormality of proline metabolism (HP:0010907)2.05770805
141Irritability (HP:0000737)2.03714766
142Increased mean platelet volume (HP:0011877)2.00782291
143Segmental peripheral demyelination/remyelination (HP:0003481)1.98526974
144Epistaxis (HP:0000421)1.96852072
145Increased cerebral lipofuscin (HP:0011813)1.96451025
146Abnormal platelet volume (HP:0011876)1.95959716
147Neonatal onset (HP:0003623)1.95800138
148Abnormality of T cells (HP:0002843)1.95378068
149Granulocytopenia (HP:0001913)1.95130331
150Loss of speech (HP:0002371)1.93778832
151Leukocytosis (HP:0001974)1.93607094
152Osteomyelitis (HP:0002754)1.92085473
153Lethargy (HP:0001254)1.91604729
154Episodic fever (HP:0001954)1.91548902
155Cerebral aneurysm (HP:0004944)1.91318445
156Acne (HP:0001061)1.91287821
157Increased serum ferritin (HP:0003281)1.91242331
158Abnormality of the gallbladder (HP:0005264)1.90247681
159Lymphopenia (HP:0001888)1.89526840
160Broad face (HP:0000283)1.88744877
161Premature loss of primary teeth (HP:0006323)1.88460939
162Papilloma (HP:0012740)1.84884003
163Verrucae (HP:0200043)1.84884003
164Abnormality of glycolipid metabolism (HP:0010969)1.83721726
165Abnormality of liposaccharide metabolism (HP:0010968)1.83721726
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.83721726
167Gastrointestinal stroma tumor (HP:0100723)1.82955429
168Abnormality of the pleura (HP:0002103)1.82033172
169Impaired platelet aggregation (HP:0003540)1.81677561
170Abnormal platelet function (HP:0011869)1.81677561
171Abnormal enzyme/coenzyme activity (HP:0012379)1.81222839
172Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80843153
173Subacute progressive viral hepatitis (HP:0006572)1.80818307
174Hypertriglyceridemia (HP:0002155)1.78395725
175Abnormal cartilage morphology (HP:0002763)1.78324903
176Generalized aminoaciduria (HP:0002909)1.75942475
177Elevated hepatic transaminases (HP:0002910)1.74712897
178Stroke (HP:0001297)1.73221567
179Peritonitis (HP:0002586)1.70737418
180Vomiting (HP:0002013)1.70117411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.63393679
2BCKDK4.00939402
3FGFR43.58625970
4PRPF4B3.44385613
5SIK13.41966589
6TAOK33.08372329
7TRIB33.05002607
8MAP3K102.82650974
9TYK22.71042060
10PKN22.66694004
11MAP4K12.32469960
12TBK12.13524192
13MAP3K141.99791066
14SMG11.99334630
15TNK21.82417175
16GRK61.82244048
17JAK11.72174974
18PTK61.70712711
19FLT31.69036863
20FES1.64561357
21BLK1.61922853
22MAP2K31.61782098
23NEK91.58536127
24EPHB11.58088999
25MAPK111.51736969
26TGFBR21.46008379
27MST1R1.45618291
28IKBKE1.38374389
29INSRR1.35944989
30JAK21.35481809
31CSF1R1.30616960
32JAK31.27159599
33IRAK31.26934993
34CSK1.26753913
35PIK3CG1.24649288
36FRK1.22922516
37PRKD21.22209842
38KIT1.18452115
39SIK31.16953191
40MARK21.16863273
41ERBB41.15867644
42ZAP701.13209587
43CDC42BPA1.08728340
44MAP3K71.07767981
45CAMK1D1.07452192
46FGFR31.05494358
47IKBKB1.04138641
48CDK61.03920067
49MAP3K131.03841223
50KDR1.02540446
51MAP3K31.02403942
52RIPK11.01441512
53STK241.00920931
54EEF2K0.99180258
55PRKAA20.92754119
56BTK0.91620731
57ABL20.91234926
58NLK0.90043063
59LRRK20.89631017
60HIPK20.89122235
61MAP3K20.87249473
62FGR0.85169195
63RPS6KC10.85087877
64RPS6KL10.85087877
65IRAK20.84134211
66MARK30.83850126
67CHUK0.83448122
68SYK0.83445497
69MAPK40.83396834
70STK100.83395255
71DYRK1B0.82750128
72EPHA30.81661599
73KSR20.81297658
74IRAK10.79447235
75MAP3K110.76201765
76CDK40.76082064
77LATS10.75848844
78RPS6KA20.74653253
79PIM10.73699448
80IRAK40.73121779
81MAP2K40.72466679
82RPS6KA60.71000968
83STK380.69641318
84STK40.69331550
85CAMKK10.68801919
86TTN0.67333855
87BMX0.66998336
88EPHA20.66905142
89MAP3K60.64421568
90SGK30.63882932
91MAPK120.60782968
92HCK0.60527932
93ITK0.56832578
94PDPK10.56005368
95LYN0.55495270
96PAK40.55053669
97PRKCQ0.54188926
98SIK20.53801468
99CAMK1G0.52498271
100GSK3A0.52141839
101MELK0.50210672
102PRKG20.50202043
103STK30.50013959
104PDK10.49923805
105FGFR20.49490174
106RET0.47653546
107PRKCZ0.47561841
108DAPK20.46414318
109YES10.45530364
110TESK20.45490831
111MAP3K50.44384612
112LCK0.44096451
113TAOK20.43913299
114PRKAA10.43204145
115FYN0.42981891
116EGFR0.42625329
117PRKACG0.41243246
118PTK20.40574898
119MAPKAPK20.40379172
120MATK0.39179485
121ABL10.37936155
122MTOR0.37564836
123PDGFRB0.37276710
124MAPK70.36956657
125MAP2K60.36436140
126MAP3K80.35696043
127RIPK40.35643426
128TAOK10.35325559
129ERBB20.35188093
130CDK120.33840151
131MAP3K10.32490611
132RPS6KA40.29207636
133TXK0.29041691
134ICK0.27725931

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40062325
2Nitrogen metabolism_Homo sapiens_hsa009103.59810485
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.52417216
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40954750
5Arginine biosynthesis_Homo sapiens_hsa002202.97609198
6Complement and coagulation cascades_Homo sapiens_hsa046102.86701130
7Tryptophan metabolism_Homo sapiens_hsa003802.67995424
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52077288
9Fatty acid degradation_Homo sapiens_hsa000712.46646644
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42092805
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39576139
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31360318
13Staphylococcus aureus infection_Homo sapiens_hsa051502.24045117
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22960596
15Other glycan degradation_Homo sapiens_hsa005112.04476125
16Caffeine metabolism_Homo sapiens_hsa002322.03612023
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01823671
18Peroxisome_Homo sapiens_hsa041461.97805591
19PPAR signaling pathway_Homo sapiens_hsa033201.93811015
20Chemical carcinogenesis_Homo sapiens_hsa052041.87948763
21Histidine metabolism_Homo sapiens_hsa003401.87017537
22Butanoate metabolism_Homo sapiens_hsa006501.86129831
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82752886
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80267545
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.80237666
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.75501484
27Allograft rejection_Homo sapiens_hsa053301.73623923
28Autoimmune thyroid disease_Homo sapiens_hsa053201.72521318
29Graft-versus-host disease_Homo sapiens_hsa053321.70330700
30T cell receptor signaling pathway_Homo sapiens_hsa046601.70147342
31Fatty acid metabolism_Homo sapiens_hsa012121.68595622
32beta-Alanine metabolism_Homo sapiens_hsa004101.66718335
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66615789
34Propanoate metabolism_Homo sapiens_hsa006401.63547171
35Retinol metabolism_Homo sapiens_hsa008301.62568331
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62405173
37Tuberculosis_Homo sapiens_hsa051521.60217681
38Selenocompound metabolism_Homo sapiens_hsa004501.53494315
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52780042
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52223480
41Bile secretion_Homo sapiens_hsa049761.52131774
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49661904
43Toxoplasmosis_Homo sapiens_hsa051451.46125782
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44602562
45TNF signaling pathway_Homo sapiens_hsa046681.44458698
46Phenylalanine metabolism_Homo sapiens_hsa003601.43251569
47ABC transporters_Homo sapiens_hsa020101.39306696
48Chemokine signaling pathway_Homo sapiens_hsa040621.34393569
49Starch and sucrose metabolism_Homo sapiens_hsa005001.31290383
50Fat digestion and absorption_Homo sapiens_hsa049751.29379772
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29118928
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29105067
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.28066030
54Hematopoietic cell lineage_Homo sapiens_hsa046401.27915845
55Chronic myeloid leukemia_Homo sapiens_hsa052201.27408924
56Non-small cell lung cancer_Homo sapiens_hsa052231.27347349
57Sulfur metabolism_Homo sapiens_hsa009201.24105098
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.23539834
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23277826
60Tyrosine metabolism_Homo sapiens_hsa003501.23261530
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20659634
62Hepatitis B_Homo sapiens_hsa051611.17565796
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17207411
64VEGF signaling pathway_Homo sapiens_hsa043701.16767503
65Folate biosynthesis_Homo sapiens_hsa007901.16440507
66Notch signaling pathway_Homo sapiens_hsa043301.15027567
67Pyruvate metabolism_Homo sapiens_hsa006201.14288830
68Viral myocarditis_Homo sapiens_hsa054161.13969010
69Herpes simplex infection_Homo sapiens_hsa051681.10623772
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.10263625
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09899373
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08379825
73Pancreatic cancer_Homo sapiens_hsa052121.06268933
74Type I diabetes mellitus_Homo sapiens_hsa049401.03217343
75Renal cell carcinoma_Homo sapiens_hsa052111.02574486
76Biosynthesis of amino acids_Homo sapiens_hsa012300.99889942
77Antigen processing and presentation_Homo sapiens_hsa046120.99373585
78Fatty acid elongation_Homo sapiens_hsa000620.97586696
79Carbon metabolism_Homo sapiens_hsa012000.96193242
80Endometrial cancer_Homo sapiens_hsa052130.95395787
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.94257981
82Apoptosis_Homo sapiens_hsa042100.94026795
83Vitamin digestion and absorption_Homo sapiens_hsa049770.93412438
84Lysine degradation_Homo sapiens_hsa003100.93279753
85Prolactin signaling pathway_Homo sapiens_hsa049170.93160355
86Phagosome_Homo sapiens_hsa041450.93082462
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.93077974
88Sulfur relay system_Homo sapiens_hsa041220.90670917
89Platelet activation_Homo sapiens_hsa046110.89987643
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88124103
91Amoebiasis_Homo sapiens_hsa051460.87845138
92Steroid biosynthesis_Homo sapiens_hsa001000.85405414
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83131370
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.82655963
95mTOR signaling pathway_Homo sapiens_hsa041500.79182430
96Arginine and proline metabolism_Homo sapiens_hsa003300.78738730
97Endocytosis_Homo sapiens_hsa041440.77473511
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.76144625
99FoxO signaling pathway_Homo sapiens_hsa040680.74718207
100Shigellosis_Homo sapiens_hsa051310.73514206
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73173109
102Salmonella infection_Homo sapiens_hsa051320.72484770
103Glycerolipid metabolism_Homo sapiens_hsa005610.72472086
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.71662267
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70856612
106Vitamin B6 metabolism_Homo sapiens_hsa007500.70471738
107Choline metabolism in cancer_Homo sapiens_hsa052310.69613582
108Insulin signaling pathway_Homo sapiens_hsa049100.65935906
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65176896
110Pentose phosphate pathway_Homo sapiens_hsa000300.64254976
111Prostate cancer_Homo sapiens_hsa052150.63074201
112HTLV-I infection_Homo sapiens_hsa051660.62010826
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61686363
114Thyroid cancer_Homo sapiens_hsa052160.61457826
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60450044
116Colorectal cancer_Homo sapiens_hsa052100.60057547
117Viral carcinogenesis_Homo sapiens_hsa052030.59991905
118GnRH signaling pathway_Homo sapiens_hsa049120.59852417
119One carbon pool by folate_Homo sapiens_hsa006700.58290017
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58039615
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57398960
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56944504
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56528905
124Glutathione metabolism_Homo sapiens_hsa004800.54234078
125Inositol phosphate metabolism_Homo sapiens_hsa005620.54196170
126Rheumatoid arthritis_Homo sapiens_hsa053230.53931714
127HIF-1 signaling pathway_Homo sapiens_hsa040660.53289602
128Bladder cancer_Homo sapiens_hsa052190.52881666
129ErbB signaling pathway_Homo sapiens_hsa040120.52535687
130Rap1 signaling pathway_Homo sapiens_hsa040150.51074377
131Small cell lung cancer_Homo sapiens_hsa052220.49499035
132Asthma_Homo sapiens_hsa053100.49482507
133MAPK signaling pathway_Homo sapiens_hsa040100.49201431
134Focal adhesion_Homo sapiens_hsa045100.48541542
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47946066
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46945687
137Insulin resistance_Homo sapiens_hsa049310.45762196
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.42902595
139Fatty acid biosynthesis_Homo sapiens_hsa000610.35564345
140Prion diseases_Homo sapiens_hsa050200.30977795
141Metabolic pathways_Homo sapiens_hsa011000.29738850
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.25395582
143Galactose metabolism_Homo sapiens_hsa000520.24511204
144Fructose and mannose metabolism_Homo sapiens_hsa000510.19984691
145Leishmaniasis_Homo sapiens_hsa051400.17996138
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17495057
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15218044
148Pertussis_Homo sapiens_hsa051330.14092351
149B cell receptor signaling pathway_Homo sapiens_hsa046620.14008344
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.13330943
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13223806
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.11223716
153RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10917946
154Osteoclast differentiation_Homo sapiens_hsa043800.10887470
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10335108
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.08055007
157Hepatitis C_Homo sapiens_hsa051600.07582279
158Linoleic acid metabolism_Homo sapiens_hsa005910.06343676
159AMPK signaling pathway_Homo sapiens_hsa041520.06035031
160Lysosome_Homo sapiens_hsa041420.05602545
161Malaria_Homo sapiens_hsa051440.02413132
162Systemic lupus erythematosus_Homo sapiens_hsa053220.02006111
163Glucagon signaling pathway_Homo sapiens_hsa049220.00991475
164Acute myeloid leukemia_Homo sapiens_hsa05221-0.0311680
165Influenza A_Homo sapiens_hsa05164-0.0249404
166Renin-angiotensin system_Homo sapiens_hsa04614-0.0219431
167African trypanosomiasis_Homo sapiens_hsa05143-0.0216912
168Measles_Homo sapiens_hsa05162-0.0200633
169Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0150512
170Primary immunodeficiency_Homo sapiens_hsa05340-0.0104555
171Legionellosis_Homo sapiens_hsa05134-0.0018298

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