RAB4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood coagulation, intrinsic pathway (GO:0007597)5.47181252
2central nervous system myelination (GO:0022010)5.28643375
3axon ensheathment in central nervous system (GO:0032291)5.28643375
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.76384032
5negative regulation of heart rate (GO:0010459)4.74138941
6negative regulation of norepinephrine secretion (GO:0010700)4.54291876
7fatty acid elongation (GO:0030497)4.40669530
8regulation of Golgi to plasma membrane protein transport (GO:0042996)4.21231121
9positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.17411072
10polyamine biosynthetic process (GO:0006596)4.14789071
11negative regulation of response to food (GO:0032096)4.05550085
12negative regulation of appetite (GO:0032099)4.05550085
13chaperone-mediated protein transport (GO:0072321)3.97984299
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95381447
15regulation of lipoprotein metabolic process (GO:0050746)3.94092747
16thrombin receptor signaling pathway (GO:0070493)3.92977682
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92240423
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.91442815
19L-phenylalanine catabolic process (GO:0006559)3.91442815
20low-density lipoprotein particle remodeling (GO:0034374)3.89392311
21regulation of integrin-mediated signaling pathway (GO:2001044)3.88442566
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.82988639
23L-phenylalanine metabolic process (GO:0006558)3.82988639
24ATP synthesis coupled proton transport (GO:0015986)3.76192292
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76192292
26adenosine receptor signaling pathway (GO:0001973)3.69186660
27establishment of mitochondrion localization (GO:0051654)3.68311304
28pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.65158215
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.64202060
30negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.63043397
31negative regulation of catecholamine secretion (GO:0033604)3.55984065
32negative regulation of protein localization to cell surface (GO:2000009)3.55662360
33substantia nigra development (GO:0021762)3.54785979
34lipoxygenase pathway (GO:0019372)3.50320826
35respiratory electron transport chain (GO:0022904)3.45849353
36neuronal action potential propagation (GO:0019227)3.44899538
37neutrophil activation involved in immune response (GO:0002283)3.44570463
38electron transport chain (GO:0022900)3.39898951
39mitochondrial calcium ion transport (GO:0006851)3.34462990
40negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.31706274
41negative regulation of calcium ion transmembrane transport (GO:1903170)3.31706274
42peroxisome fission (GO:0016559)3.28392578
43positive regulation of endothelial cell differentiation (GO:0045603)3.26857580
44synaptic vesicle exocytosis (GO:0016079)3.26272164
45negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.26114496
46glutamate secretion (GO:0014047)3.24031310
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23318091
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.22247721
49synaptic vesicle maturation (GO:0016188)3.22090446
50regulation of platelet activation (GO:0010543)3.21059322
51platelet aggregation (GO:0070527)3.15515484
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15170924
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15149215
54polyamine metabolic process (GO:0006595)3.14782669
55pyrimidine nucleotide catabolic process (GO:0006244)3.14208233
56negative regulation of homotypic cell-cell adhesion (GO:0034111)3.13431397
57negative regulation of heart contraction (GO:0045822)3.12666873
58reverse cholesterol transport (GO:0043691)3.09593018
59neuromuscular process controlling posture (GO:0050884)3.09403119
60high-density lipoprotein particle remodeling (GO:0034375)3.07176202
61cholesterol biosynthetic process (GO:0006695)3.06803437
62regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.05917417
63platelet degranulation (GO:0002576)3.05057252
64regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.04104679
65negative regulation of cation channel activity (GO:2001258)3.02510240
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.97266213
67NADH dehydrogenase complex assembly (GO:0010257)2.97266213
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97266213
69regulation of platelet aggregation (GO:0090330)2.96490747
70negative regulation of platelet activation (GO:0010544)2.94332036
71axon ensheathment (GO:0008366)2.92744460
72ensheathment of neurons (GO:0007272)2.92744460
73coenzyme catabolic process (GO:0009109)2.92733153
74myelination (GO:0042552)2.92611314
75detection of temperature stimulus involved in sensory perception (GO:0050961)2.91423506
76detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.91423506
77relaxation of smooth muscle (GO:0044557)2.91146869
78phospholipid homeostasis (GO:0055091)2.90700536
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.90020909
80regulation of oxidative phosphorylation (GO:0002082)2.89652274
81dopamine transport (GO:0015872)2.88408781
82regulation of norepinephrine secretion (GO:0014061)2.88170428
83protein complex biogenesis (GO:0070271)2.88061854
84regulation of cAMP-dependent protein kinase activity (GO:2000479)2.87327540
85aspartate family amino acid catabolic process (GO:0009068)2.86786157
86positive regulation of blood coagulation (GO:0030194)2.86470135
87positive regulation of hemostasis (GO:1900048)2.86470135
88neurotransmitter catabolic process (GO:0042135)2.83654085
89protein neddylation (GO:0045116)2.83364878
90negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82219236
91neurotransmitter uptake (GO:0001504)2.79270423
92mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.77541406
93peptidyl-cysteine modification (GO:0018198)2.76399579
94heme transport (GO:0015886)2.75658857
95sarcoplasmic reticulum calcium ion transport (GO:0070296)2.75372433
96long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.74248870
97response to methylmercury (GO:0051597)2.73851796
98negative regulation of microtubule polymerization (GO:0031115)2.72698711
99mitochondrial respiratory chain complex assembly (GO:0033108)2.72521076
100cyclooxygenase pathway (GO:0019371)2.71635671
101negative regulation of dendrite morphogenesis (GO:0050774)2.71088520
102neuron cell-cell adhesion (GO:0007158)2.70900980
103L-methionine salvage (GO:0071267)2.70722002
104L-methionine biosynthetic process (GO:0071265)2.70722002
105amino acid salvage (GO:0043102)2.70722002
106detection of temperature stimulus (GO:0016048)2.69026508
107regulation of catecholamine metabolic process (GO:0042069)2.68253802
108regulation of dopamine metabolic process (GO:0042053)2.68253802
109dicarboxylic acid catabolic process (GO:0043649)2.67268233
110sterol biosynthetic process (GO:0016126)2.66953474
111regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65957392
112iron coordination entity transport (GO:1901678)2.65023250
113negative regulation of neurotransmitter transport (GO:0051589)2.64543838
114protein deneddylation (GO:0000338)2.62552180
115negative regulation of blood circulation (GO:1903523)2.62299142
116mitochondrial calcium ion homeostasis (GO:0051560)2.62140087
117regulation of cholesterol esterification (GO:0010872)2.61188858
118glycerophospholipid catabolic process (GO:0046475)2.61135954
119calcium-mediated signaling using intracellular calcium source (GO:0035584)2.60461992
120heart contraction (GO:0060047)2.60409213
121heart process (GO:0003015)2.60409213
122regulation of response to food (GO:0032095)2.60134587
123gamma-aminobutyric acid transport (GO:0015812)2.60070014
124sequestering of actin monomers (GO:0042989)2.59802000
125positive regulation of coagulation (GO:0050820)2.59743966
126negative regulation of thymocyte apoptotic process (GO:0070244)2.58418539
127cellular biogenic amine biosynthetic process (GO:0042401)2.58149154
128positive regulation of Rho protein signal transduction (GO:0035025)2.57730014
129fatty-acyl-CoA biosynthetic process (GO:0046949)2.57513662
130positive regulation of systemic arterial blood pressure (GO:0003084)2.57471489
131beta-amyloid metabolic process (GO:0050435)2.57456671
132cellular response to leptin stimulus (GO:0044320)2.57359077
133nucleoside diphosphate biosynthetic process (GO:0009133)2.56994389
134ether lipid metabolic process (GO:0046485)2.55757895
135ATP biosynthetic process (GO:0006754)2.55748896
136tonic smooth muscle contraction (GO:0014820)2.55596924
137oxidative phosphorylation (GO:0006119)2.55411114
138very long-chain fatty acid metabolic process (GO:0000038)2.55403040
139acyl-CoA biosynthetic process (GO:0071616)2.54978579
140thioester biosynthetic process (GO:0035384)2.54978579
141regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.54413597
142regulation of collateral sprouting (GO:0048670)2.54013094
143regulation of synaptic vesicle exocytosis (GO:2000300)2.53398422
144positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53244768
145regulation of receptor recycling (GO:0001919)2.52330372
146regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51869447
147establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50206994
148mitochondrion transport along microtubule (GO:0047497)2.50206994
149positive regulation of mitochondrial fission (GO:0090141)2.49587755
150relaxation of muscle (GO:0090075)2.47836075
151cofactor catabolic process (GO:0051187)2.46679774
152regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46649575
153dopamine biosynthetic process (GO:0042416)2.45510919
154long-chain fatty acid biosynthetic process (GO:0042759)2.45125091
155negative regulation of protein localization to plasma membrane (GO:1903077)2.44652206
156positive regulation of TOR signaling (GO:0032008)2.44432384
157long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.44182441
158protein localization to synapse (GO:0035418)2.43799218
159regulation of clathrin-mediated endocytosis (GO:2000369)2.43522710
160negative regulation of amine transport (GO:0051953)2.43411092
161negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.42089721
162tyrosine metabolic process (GO:0006570)2.41448278
163response to redox state (GO:0051775)2.40710584
164linoleic acid metabolic process (GO:0043651)2.39429629
165adult walking behavior (GO:0007628)2.38961887
166cellular response to glucagon stimulus (GO:0071377)2.38843588
167fatty-acyl-CoA metabolic process (GO:0035337)2.38558004
168regulation of protein localization to cell surface (GO:2000008)2.38545927
169protein maturation by protein folding (GO:0022417)2.37617156
170pyrimidine nucleobase catabolic process (GO:0006208)2.36779014
171response to misfolded protein (GO:0051788)2.36514021
172response to mercury ion (GO:0046689)2.36408600
173neural nucleus development (GO:0048857)2.36198547
174glutathione biosynthetic process (GO:0006750)2.35535586
175cullin deneddylation (GO:0010388)2.34857394
176behavioral response to cocaine (GO:0048148)2.34750165
177neurotransmitter secretion (GO:0007269)2.34241716
178neurofilament cytoskeleton organization (GO:0060052)2.33518153
179hydrogen ion transmembrane transport (GO:1902600)2.33462586
180cysteine metabolic process (GO:0006534)2.33125066
181regulation of synaptic vesicle transport (GO:1902803)2.33005138
182energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.32908098
183ATP hydrolysis coupled proton transport (GO:0015991)2.32908098
184aromatic amino acid family catabolic process (GO:0009074)2.31910193
185neurotransmitter transport (GO:0006836)2.31773051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_19796622_ChIP-Seq_MESCs_Mouse3.28637019
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23235434
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.88667120
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.74539714
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61770425
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58469088
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33738845
8* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.24102195
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23452468
10EZH2_22144423_ChIP-Seq_EOC_Human2.21694506
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20410914
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19281053
13GBX2_23144817_ChIP-Seq_PC3_Human2.17637505
14* REST_18959480_ChIP-ChIP_MESCs_Mouse2.11879996
15REST_21632747_ChIP-Seq_MESCs_Mouse2.09368716
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03632980
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02431742
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01334906
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00365090
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87516221
21RNF2_27304074_Chip-Seq_NSC_Mouse1.76911839
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74889312
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70578750
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67985112
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67278311
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65963695
27* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59823779
28* RARB_27405468_Chip-Seq_BRAIN_Mouse1.57458535
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53883853
30ZNF263_19887448_ChIP-Seq_K562_Human1.53860399
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52333500
32* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49986119
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48536275
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47995251
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.46437080
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45761099
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45761099
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43408795
39CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.42814420
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42252780
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39765569
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38397274
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36577700
44TAF15_26573619_Chip-Seq_HEK293_Human1.35995270
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35976929
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.33516167
47SCL_19346495_ChIP-Seq_HPC-7_Human1.32300934
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32190432
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32190432
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.31135675
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30461566
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28730192
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28363947
54EOMES_21245162_ChIP-Seq_HESCs_Human1.27987386
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.27829317
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.25713754
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.25471474
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.25332250
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24815646
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.24400725
61* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23209376
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22906098
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20949003
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.20779362
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19906427
66EWS_26573619_Chip-Seq_HEK293_Human1.18477316
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.18402406
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.18104804
69P53_22387025_ChIP-Seq_ESCs_Mouse1.17968326
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17903479
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17754214
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17514946
73* GATA2_19941826_ChIP-Seq_K562_Human1.17181657
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.16073371
75HTT_18923047_ChIP-ChIP_STHdh_Human1.14655168
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14218495
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13858245
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13757971
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13173854
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.12722791
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12564012
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11985381
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11159784
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11000818
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10950074
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09645990
87IGF1R_20145208_ChIP-Seq_DFB_Human1.09553263
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09056808
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07768072
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07722458
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.07657853
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06930997
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06702120
94VDR_22108803_ChIP-Seq_LS180_Human1.05112685
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04320678
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.04047815
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03559869
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02780210
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.02350678
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02232781
101GATA1_19941826_ChIP-Seq_K562_Human1.02221623
102NCOR_22424771_ChIP-Seq_293T_Human1.01329995
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01164528
104AR_21572438_ChIP-Seq_LNCaP_Human1.00566522
105REST_19997604_ChIP-ChIP_NEURONS_Mouse1.00415547
106SOX2_20726797_ChIP-Seq_SW620_Human0.99542960
107SMAD4_21799915_ChIP-Seq_A2780_Human0.99030692
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.98985829
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98630465
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98611935
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98405185
112MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98278063
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98272215
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.98132616
115* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97685936
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97681265
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96443580
118ZNF274_21170338_ChIP-Seq_K562_Hela0.95489910
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95460336
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.94087984
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93842913
122PU1_27457419_Chip-Seq_LIVER_Mouse0.93124255
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.90906243
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90760600
125* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90751694
126* LXR_22158963_ChIP-Seq_LIVER_Mouse0.90329191
127* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89889933
128HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89723043
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89338287
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88716801
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87930567
132EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87654118
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87632617
134* GABP_19822575_ChIP-Seq_HepG2_Human0.87591937
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.87394577
136* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87111686
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86835567
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86665557
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.86202821
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85917428
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84909488
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84787158
143AR_25329375_ChIP-Seq_VCAP_Human0.83662687
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83602737
145IRF1_19129219_ChIP-ChIP_H3396_Human0.83130616
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82759622
147Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82414698
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81791257
149* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81398334
150* CTCF_20526341_ChIP-Seq_ESCs_Human0.81385339
151* CTCF_27219007_Chip-Seq_Bcells_Human0.81383761
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81340286
153ERG_20517297_ChIP-Seq_VCAP_Human0.81255484
154AR_20517297_ChIP-Seq_VCAP_Human0.81193108
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81163317
156OCT4_20526341_ChIP-Seq_ESCs_Human0.80711236
157EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80711127
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80176446
159STAT3_18555785_Chip-Seq_ESCs_Mouse0.80063247
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79031765
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.78384678
162* RBPJ_21746931_ChIP-Seq_IB4_Human0.78161719
163* P300_19829295_ChIP-Seq_ESCs_Human0.77685031
164GATA1_26923725_Chip-Seq_HPCs_Mouse0.77257154
165SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76826337
166CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75895789
167CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75793361
168SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74518081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.38555521
2MP0008004_abnormal_stomach_pH3.65506939
3MP0004270_analgesia3.42159557
4MP0003806_abnormal_nucleotide_metabolis3.41119710
5MP0002139_abnormal_hepatobiliary_system3.23556773
6MP0001529_abnormal_vocalization3.17766413
7MP0003880_abnormal_central_pattern2.83366945
8MP0004859_abnormal_synaptic_plasticity2.74906199
9MP0005360_urolithiasis2.62721014
10MP0002734_abnormal_mechanical_nocicepti2.42402201
11MP0004036_abnormal_muscle_relaxation2.41050776
12MP0002272_abnormal_nervous_system2.26624336
13MP0004215_abnormal_myocardial_fiber2.26554676
14MP0004084_abnormal_cardiac_muscle2.25862734
15MP0004142_abnormal_muscle_tone2.24590277
16MP0001905_abnormal_dopamine_level2.18948394
17MP0003635_abnormal_synaptic_transmissio2.18014736
18MP0002064_seizures2.13304892
19MP0001968_abnormal_touch/_nociception2.09322865
20MP0003329_amyloid_beta_deposits2.08113888
21MP0005670_abnormal_white_adipose2.07466106
22MP0005085_abnormal_gallbladder_physiolo2.06644965
23MP0009745_abnormal_behavioral_response2.05185301
24MP0004147_increased_porphyrin_level2.00244416
25MP0006276_abnormal_autonomic_nervous1.95860717
26MP0004885_abnormal_endolymph1.95845584
27MP0000920_abnormal_myelination1.91403796
28MP0004043_abnormal_pH_regulation1.90032869
29MP0009046_muscle_twitch1.84478920
30MP0002735_abnormal_chemical_nociception1.84187757
31MP0000465_gastrointestinal_hemorrhage1.81537429
32MP0002736_abnormal_nociception_after1.78061574
33MP0002822_catalepsy1.77909530
34MP0002733_abnormal_thermal_nociception1.77805379
35MP0002234_abnormal_pharynx_morphology1.74978286
36MP0001986_abnormal_taste_sensitivity1.68171308
37MP0005167_abnormal_blood-brain_barrier1.67475706
38MP0002063_abnormal_learning/memory/cond1.67396924
39MP0001486_abnormal_startle_reflex1.66808182
40MP0001970_abnormal_pain_threshold1.66774972
41MP0002572_abnormal_emotion/affect_behav1.66288189
42MP0003122_maternal_imprinting1.65571036
43MP0003186_abnormal_redox_activity1.58542800
44MP0005084_abnormal_gallbladder_morpholo1.57832585
45MP0005646_abnormal_pituitary_gland1.55868083
46MP0008775_abnormal_heart_ventricle1.54294666
47MP0010329_abnormal_lipoprotein_level1.49374659
48MP0006036_abnormal_mitochondrial_physio1.49061286
49MP0008875_abnormal_xenobiotic_pharmacok1.48916772
50MP0004130_abnormal_muscle_cell1.48890529
51MP0005423_abnormal_somatic_nervous1.46872280
52MP0009780_abnormal_chondrocyte_physiolo1.45458342
53MP0005187_abnormal_penis_morphology1.45362316
54MP0009379_abnormal_foot_pigmentation1.42853029
55MP0001485_abnormal_pinna_reflex1.42163988
56MP0004924_abnormal_behavior1.41551755
57MP0005386_behavior/neurological_phenoty1.41551755
58MP0002972_abnormal_cardiac_muscle1.40565240
59MP0000343_altered_response_to1.40069030
60MP0000955_abnormal_spinal_cord1.37422948
61MP0002067_abnormal_sensory_capabilities1.37283877
62MP0003787_abnormal_imprinting1.35979715
63MP0002229_neurodegeneration1.34739246
64MP0001440_abnormal_grooming_behavior1.34248736
65MP0000778_abnormal_nervous_system1.33676718
66MP0005365_abnormal_bile_salt1.33274708
67MP0003950_abnormal_plasma_membrane1.33181658
68MP0005666_abnormal_adipose_tissue1.32259820
69MP0000230_abnormal_systemic_arterial1.28012463
70MP0004085_abnormal_heartbeat1.24919746
71MP0004858_abnormal_nervous_system1.22663718
72MP0005620_abnormal_muscle_contractility1.22342388
73MP0009697_abnormal_copulation1.22123911
74MP0002909_abnormal_adrenal_gland1.21441672
75MP0005083_abnormal_biliary_tract1.19374434
76MP0005332_abnormal_amino_acid1.18068861
77MP0006035_abnormal_mitochondrial_morpho1.17050169
78MP0008872_abnormal_physiological_respon1.17009017
79MP0004510_myositis1.16377514
80MP0005451_abnormal_body_composition1.16193902
81MP0002837_dystrophic_cardiac_calcinosis1.15762161
82MP0003638_abnormal_response/metabolism_1.15745227
83MP0005058_abnormal_lysosome_morphology1.15170383
84MP0008569_lethality_at_weaning1.14760387
85MP0004133_heterotaxia1.13434560
86MP0002090_abnormal_vision1.13432195
87MP0002882_abnormal_neuron_morphology1.13208380
88MP0002184_abnormal_innervation1.13037057
89MP0002066_abnormal_motor_capabilities/c1.12821971
90MP0001188_hyperpigmentation1.10726018
91MP0009840_abnormal_foam_cell1.08241288
92MP0002638_abnormal_pupillary_reflex1.06358924
93MP0001984_abnormal_olfaction1.04827456
94MP0003656_abnormal_erythrocyte_physiolo1.03693078
95MP0003011_delayed_dark_adaptation1.02907740
96MP0002557_abnormal_social/conspecific_i1.02077200
97MP0002653_abnormal_ependyma_morphology1.00698934
98MP0003634_abnormal_glial_cell1.00607535
99MP0003123_paternal_imprinting1.00255019
100MP0003632_abnormal_nervous_system0.98302693
101MP0005551_abnormal_eye_electrophysiolog0.97054264
102MP0005385_cardiovascular_system_phenoty0.95813490
103MP0001544_abnormal_cardiovascular_syste0.95813490
104MP0005266_abnormal_metabolism0.95696913
105MP0001666_abnormal_nutrient_absorption0.95620134
106MP0003631_nervous_system_phenotype0.95242409
107MP0004145_abnormal_muscle_electrophysio0.94558682
108MP0004811_abnormal_neuron_physiology0.94413673
109MP0006138_congestive_heart_failure0.91774969
110MP0002118_abnormal_lipid_homeostasis0.91122804
111MP0003195_calcinosis0.91121313
112MP0001756_abnormal_urination0.89938747
113MP0003633_abnormal_nervous_system0.89615933
114MP0005501_abnormal_skin_physiology0.89583718
115MP0003868_abnormal_feces_composition0.89536220
116MP0003690_abnormal_glial_cell0.89433579
117MP0000749_muscle_degeneration0.88913080
118MP0005636_abnormal_mineral_homeostasis0.88567764
119MP0002752_abnormal_somatic_nervous0.86439963
120MP0003121_genomic_imprinting0.85785960
121MP0001963_abnormal_hearing_physiology0.85380966
122MP0005535_abnormal_body_temperature0.85298140
123MP0005645_abnormal_hypothalamus_physiol0.84249897
124MP0000747_muscle_weakness0.83930613
125MP0000639_abnormal_adrenal_gland0.83330329
126MP0005394_taste/olfaction_phenotype0.82965473
127MP0005499_abnormal_olfactory_system0.82965473
128MP0002332_abnormal_exercise_endurance0.81641407
129MP0004484_altered_response_of0.80689965
130MP0000462_abnormal_digestive_system0.80397003
131MP0004742_abnormal_vestibular_system0.79955435
132MP0002152_abnormal_brain_morphology0.79646719
133MP0005408_hypopigmentation0.79228766
134MP0001664_abnormal_digestion0.78557357
135MP0005584_abnormal_enzyme/coenzyme_acti0.76748261
136MP0003137_abnormal_impulse_conducting0.76372703
137MP0000358_abnormal_cell_content/0.74523032
138MP0009642_abnormal_blood_homeostasis0.73537007
139MP0005248_abnormal_Harderian_gland0.72715005
140MP0003718_maternal_effect0.72664205
141MP0000604_amyloidosis0.72344048
142MP0008789_abnormal_olfactory_epithelium0.71842579
143MP0001502_abnormal_circadian_rhythm0.71794028
144MP0002233_abnormal_nose_morphology0.71793491
145MP0002078_abnormal_glucose_homeostasis0.71366332
146MP0006072_abnormal_retinal_apoptosis0.71112666
147MP0003566_abnormal_cell_adhesion0.70494099
148MP0001764_abnormal_homeostasis0.69811613
149MP0005410_abnormal_fertilization0.69208713
150MP0003879_abnormal_hair_cell0.69094851

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)7.27301150
2Prolonged bleeding time (HP:0003010)7.16741774
3Menorrhagia (HP:0000132)6.97550381
4Abnormal platelet volume (HP:0011876)6.47795361
5Purpura (HP:0000979)6.38802237
6Petechiae (HP:0000967)6.38649186
7Myokymia (HP:0002411)4.38610803
8Hyperlipoproteinemia (HP:0010980)4.28214281
9Epistaxis (HP:0000421)4.24680025
10Pheochromocytoma (HP:0002666)4.23760414
11Neuroendocrine neoplasm (HP:0100634)4.01973418
12Acanthocytosis (HP:0001927)4.01387010
13Cerebral hypomyelination (HP:0006808)3.91026017
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.88452204
15Acute necrotizing encephalopathy (HP:0006965)3.84446094
16Gingival bleeding (HP:0000225)3.83363246
17Abnormality of glycolysis (HP:0004366)3.78545400
18Increased serum pyruvate (HP:0003542)3.78545400
19Acute encephalopathy (HP:0006846)3.73167398
20Abnormal platelet function (HP:0011869)3.63625392
21Impaired platelet aggregation (HP:0003540)3.63625392
22Abnormal mitochondria in muscle tissue (HP:0008316)3.58172633
23Abnormal gallbladder physiology (HP:0012438)3.31421808
24Cholecystitis (HP:0001082)3.31421808
25Hypoglycemic coma (HP:0001325)3.28850638
26Mitochondrial inheritance (HP:0001427)3.17252647
27Leukodystrophy (HP:0002415)3.16543859
28Generalized aminoaciduria (HP:0002909)3.12865074
29Intrahepatic cholestasis (HP:0001406)3.11549354
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.10527385
31Degeneration of the lateral corticospinal tracts (HP:0002314)3.10527385
32Hepatocellular necrosis (HP:0001404)3.07792096
33Progressive macrocephaly (HP:0004481)3.02101967
34Neurofibrillary tangles (HP:0002185)3.01659753
35Poikilocytosis (HP:0004447)3.00317535
36Abnormality of the corticospinal tract (HP:0002492)2.97583299
37Limb dystonia (HP:0002451)2.90382640
38Bundle branch block (HP:0011710)2.89546710
39Paralysis (HP:0003470)2.88176633
40Cerebral edema (HP:0002181)2.87332987
41Increased CSF lactate (HP:0002490)2.84730490
423-Methylglutaconic aciduria (HP:0003535)2.79794734
43CNS hypomyelination (HP:0003429)2.71508870
44Hepatic necrosis (HP:0002605)2.68587707
45Abnormal pupillary function (HP:0007686)2.61802791
46Focal motor seizures (HP:0011153)2.60584485
47Dyschromatopsia (HP:0007641)2.60099940
48Papillary thyroid carcinoma (HP:0002895)2.59171529
49Abnormality of the common coagulation pathway (HP:0010990)2.55321561
50Neoplasm of the peripheral nervous system (HP:0100007)2.49721620
51Ventricular fibrillation (HP:0001663)2.48451302
52Spastic gait (HP:0002064)2.47835475
53Sensory axonal neuropathy (HP:0003390)2.46800757
54Exercise-induced muscle cramps (HP:0003710)2.44842164
55Rimmed vacuoles (HP:0003805)2.42853444
56Abnormality of lateral ventricle (HP:0030047)2.41718323
57Ankle clonus (HP:0011448)2.38850034
58Hyperthyroidism (HP:0000836)2.36576905
59Spastic paraparesis (HP:0002313)2.36540015
60Scanning speech (HP:0002168)2.35615316
61Lactic acidosis (HP:0003128)2.33642991
62Cerebral inclusion bodies (HP:0100314)2.32837747
63Myoglobinuria (HP:0002913)2.31235751
64Poor suck (HP:0002033)2.29818171
65Xanthomatosis (HP:0000991)2.28531329
66Delusions (HP:0000746)2.28479384
67Hyperventilation (HP:0002883)2.27138246
68Termporal pattern (HP:0011008)2.24915951
69Insidious onset (HP:0003587)2.24915951
70Cerebral hemorrhage (HP:0001342)2.22342799
71Atonic seizures (HP:0010819)2.21311118
72Nemaline bodies (HP:0003798)2.20370271
73Muscle fiber inclusion bodies (HP:0100299)2.19652076
74Conjunctival telangiectasia (HP:0000524)2.17624339
75Spontaneous abortion (HP:0005268)2.16069184
76Lethargy (HP:0001254)2.15571793
77Retinal dysplasia (HP:0007973)2.13490712
78Supranuclear gaze palsy (HP:0000605)2.12759208
79Emotional lability (HP:0000712)2.12659726
80Polyphagia (HP:0002591)2.10748210
81Choreoathetosis (HP:0001266)2.09174690
82Dysmetria (HP:0001310)2.09115281
83Increased serum lactate (HP:0002151)2.09002221
84Muscular hypotonia of the trunk (HP:0008936)2.08687394
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07633800
86Anxiety (HP:0000739)2.06744881
87Hypobetalipoproteinemia (HP:0003563)2.06529896
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06519312
89Joint hemorrhage (HP:0005261)2.06402554
90Abnormality of fatty-acid metabolism (HP:0004359)2.05040202
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03944804
92Nausea (HP:0002018)2.03845590
93Delayed myelination (HP:0012448)2.01368568
94Poor speech (HP:0002465)2.01292046
95Epileptic encephalopathy (HP:0200134)2.00967268
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00899959
97Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00899959
98Thyroid carcinoma (HP:0002890)2.00847645
99Split foot (HP:0001839)1.99576897
100Renal Fanconi syndrome (HP:0001994)1.99315372
101Exercise intolerance (HP:0003546)1.99111669
102Peripheral hypomyelination (HP:0007182)1.98574105
103Respiratory failure (HP:0002878)1.97081862
104Rhabdomyolysis (HP:0003201)1.96640714
105Increased muscle lipid content (HP:0009058)1.96361813
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95853155
107Abnormality of alanine metabolism (HP:0010916)1.95853155
108Hyperalaninemia (HP:0003348)1.95853155
109Increased hepatocellular lipid droplets (HP:0006565)1.94669255
110Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94576437
111Testicular neoplasm (HP:0010788)1.93561720
112CNS demyelination (HP:0007305)1.93002868
113Focal seizures (HP:0007359)1.90686487
114Morphological abnormality of the pyramidal tract (HP:0002062)1.90479019
115Lipid accumulation in hepatocytes (HP:0006561)1.89652102
116Craniofacial dystonia (HP:0012179)1.88883209
117Hyperglycinemia (HP:0002154)1.88732735
118Visual hallucinations (HP:0002367)1.88242442
119Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88033415
120Ketosis (HP:0001946)1.87687229
121Renal tubular acidosis (HP:0001947)1.87546714
122Back pain (HP:0003418)1.87140286
123Clonus (HP:0002169)1.86712810
124Tongue fasciculations (HP:0001308)1.86439030
125Brushfield spots (HP:0001088)1.85223542
126Abnormal cartilage morphology (HP:0002763)1.85119519
127Methylmalonic aciduria (HP:0012120)1.84967794
128Hypothermia (HP:0002045)1.84346229
129Progressive inability to walk (HP:0002505)1.84331190
130Heart block (HP:0012722)1.84319711
131Abnormal auditory evoked potentials (HP:0006958)1.84070970
132Generalized tonic-clonic seizures (HP:0002069)1.83922031
133Muscle fiber splitting (HP:0003555)1.83346065
134Ketoacidosis (HP:0001993)1.82287707
135Renal cortical cysts (HP:0000803)1.81872143
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81461164
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.81436340
138Focal dystonia (HP:0004373)1.81092983
139Methylmalonic acidemia (HP:0002912)1.80763171
140Abnormal gallbladder morphology (HP:0012437)1.80755341
141Progressive external ophthalmoplegia (HP:0000590)1.79476756
142Hyperammonemia (HP:0001987)1.79328724
143Increased intramyocellular lipid droplets (HP:0012240)1.78907809
144Irritability (HP:0000737)1.78399850
145Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77927687
146Athetosis (HP:0002305)1.77850412
147Thyroid-stimulating hormone excess (HP:0002925)1.77294263
148Confusion (HP:0001289)1.76446446
149Torticollis (HP:0000473)1.76180682
150Gait imbalance (HP:0002141)1.75517246
151Optic disc pallor (HP:0000543)1.74134758
152Hypsarrhythmia (HP:0002521)1.73732765
153Delayed CNS myelination (HP:0002188)1.73576958
154Abnormality of glycine metabolism (HP:0010895)1.72852736
155Abnormality of serine family amino acid metabolism (HP:0010894)1.72852736
156EEG with generalized epileptiform discharges (HP:0011198)1.71960893
157Type II lissencephaly (HP:0007260)1.70898601
158Vaginal atresia (HP:0000148)1.70613444
159Exercise-induced myalgia (HP:0003738)1.70461749
160Arthropathy (HP:0003040)1.69760964
161Hepatosplenomegaly (HP:0001433)1.68966082
162Sudden death (HP:0001699)1.68961914
163Impaired vibration sensation in the lower limbs (HP:0002166)1.68733941
164Subaortic stenosis (HP:0001682)1.66728459
165Abnormality of the left ventricular outflow tract (HP:0011103)1.66728459
166Abnormal atrioventricular conduction (HP:0005150)1.63773439
167Renal tubular dysfunction (HP:0000124)1.60868156
168Upper limb muscle weakness (HP:0003484)1.59854532
169Hypoglycemic seizures (HP:0002173)1.59425714
170Abnormality of urine glucose concentration (HP:0011016)1.57959117
171Glycosuria (HP:0003076)1.57959117
172Hyperinsulinemic hypoglycemia (HP:0000825)1.57837764
173Fasciculations (HP:0002380)1.56949279
174Bruising susceptibility (HP:0000978)1.56527152
175Conjugated hyperbilirubinemia (HP:0002908)1.56127733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK392.98791632
2BMX2.83999700
3LIMK12.71589053
4BCKDK2.55632262
5MAPKAPK52.54849113
6ARAF2.45740662
7OXSR12.44680798
8MAP3K92.31516969
9ILK2.24219191
10TNIK2.04980491
11NTRK32.03276429
12PIM21.98396141
13BCR1.94543575
14DYRK21.94322725
15CSNK1G31.93001892
16NTRK11.89534706
17EPHA41.88883370
18MARK11.88318131
19MINK11.87321755
20CDK191.82173328
21RIPK41.81699650
22MAP3K41.80505156
23MAP2K71.78414052
24DYRK31.77305951
25TRIM281.72056589
26CSNK1G21.67700833
27UHMK11.62024907
28TESK21.53252311
29ERBB31.52116011
30GRK51.51987003
31WNK41.44860144
32MAP3K121.43863562
33KSR21.43844851
34MAP2K41.41856307
35LATS21.41593488
36PAK61.39919560
37PIK3CG1.34364251
38PRKD31.33363704
39MAPK131.32626348
40CASK1.31496261
41MUSK1.30335205
42CSNK1A1L1.29186353
43PLK21.27888935
44CSNK1G11.24083685
45CAMK2G1.22682295
46BMPR21.22455690
47CAMK2B1.20520990
48BRAF1.20472569
49ERBB41.17444220
50EPHB11.14188111
51TESK11.13076357
52BUB11.11221648
53CDK51.11112113
54PKN11.07770142
55* CDK141.07177342
56DYRK1B1.06888782
57NEK61.06623965
58EPHB21.05556068
59SGK4941.04542189
60SGK2231.04542189
61PHKG11.04435864
62PHKG21.04435864
63CAMK2D1.02878914
64NME11.02875783
65TEC1.02609163
66AKT31.02528047
67CAMK2A1.00488956
68PAK10.98239802
69ROCK20.94980868
70FER0.89495894
71PAK30.87631218
72IRAK20.87085481
73PRKD10.86785722
74NTRK20.83902468
75TYRO30.83812565
76* CDK180.82771460
77STK240.82690745
78CDK80.81090066
79EIF2AK10.78837713
80* CDK150.78794377
81OBSCN0.77238338
82DYRK1A0.77162181
83MAP3K60.77027853
84TAOK10.71847454
85PRKCG0.71419698
86TAOK30.71302327
87* CDK11A0.70912065
88PRKACG0.70239357
89CAMKK20.69869920
90STK30.69443428
91MAP3K50.69169165
92PRPF4B0.68060784
93MET0.67580227
94MATK0.67487554
95FGR0.67282183
96PINK10.66583072
97WNK10.65932585
98BMPR1B0.65516693
99STK160.65207775
100PDK20.65095070
101ERBB20.63343149
102VRK10.62998687
103PNCK0.62557126
104TNK20.61272102
105DAPK30.60581765
106RAF10.60508739
107MAP3K20.59641892
108MAP3K110.58977308
109DAPK20.57747894
110AKT20.57178334
111ABL20.56320626
112DMPK0.55318316
113MYLK0.54263416
114AURKA0.53674923
115STK38L0.53354483
116BRSK20.52622476
117PRKG10.51740465
118NEK10.51309189
119MARK20.49651617
120PKN20.49647212
121RET0.48885454
122DAPK10.48667720
123PDPK10.48575843
124SCYL20.48415202
125MAPK120.47860253
126MST40.47130929
127NEK90.46741093
128ACVR1B0.45440158
129LMTK20.44708415
130CSF1R0.44441814
131INSRR0.44195389
132ADRBK20.43872125
133BTK0.43049864
134CAMK10.42890202
135MAPKAPK30.42513596
136CSNK1E0.42063988
137ADRBK10.42058594
138MAP2K10.41723304
139PRKACA0.41436409
140PTK2B0.40430288
141PRKACB0.40151097
142PRKCE0.40087195
143GRK10.37265986

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.30137161
2Parkinsons disease_Homo sapiens_hsa050122.92217081
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.66781165
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41637483
5Fatty acid elongation_Homo sapiens_hsa000622.38537026
6Steroid biosynthesis_Homo sapiens_hsa001002.36375053
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30408959
8Platelet activation_Homo sapiens_hsa046112.29535518
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12955836
10Alzheimers disease_Homo sapiens_hsa050102.12241614
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.08988197
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02246408
13Nitrogen metabolism_Homo sapiens_hsa009102.00274088
14Pyruvate metabolism_Homo sapiens_hsa006201.99147978
15Synaptic vesicle cycle_Homo sapiens_hsa047211.96632797
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93252560
17Huntingtons disease_Homo sapiens_hsa050161.92006103
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86765724
19Folate biosynthesis_Homo sapiens_hsa007901.77538676
20Cardiac muscle contraction_Homo sapiens_hsa042601.74431565
21Butanoate metabolism_Homo sapiens_hsa006501.73980699
22Protein export_Homo sapiens_hsa030601.73398552
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67341049
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.65780233
25Propanoate metabolism_Homo sapiens_hsa006401.65651546
26Sulfur metabolism_Homo sapiens_hsa009201.64756432
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60242051
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59931462
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49583798
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46470482
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42202064
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40608195
33GABAergic synapse_Homo sapiens_hsa047271.36702931
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.32760311
35Arachidonic acid metabolism_Homo sapiens_hsa005901.29679175
36Peroxisome_Homo sapiens_hsa041461.24318063
37Nicotine addiction_Homo sapiens_hsa050331.21482966
38Collecting duct acid secretion_Homo sapiens_hsa049661.20826392
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20600325
40Arginine and proline metabolism_Homo sapiens_hsa003301.17428346
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16673536
42Starch and sucrose metabolism_Homo sapiens_hsa005001.16107308
43Proteasome_Homo sapiens_hsa030501.14163845
44Biosynthesis of amino acids_Homo sapiens_hsa012301.13284386
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12184729
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11436636
47Fatty acid metabolism_Homo sapiens_hsa012121.09980136
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07131496
49Histidine metabolism_Homo sapiens_hsa003401.06845260
50Carbon metabolism_Homo sapiens_hsa012001.06737150
51Fatty acid degradation_Homo sapiens_hsa000711.05743302
52Vitamin B6 metabolism_Homo sapiens_hsa007501.03893606
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03511492
54Arginine biosynthesis_Homo sapiens_hsa002201.02429916
55Tyrosine metabolism_Homo sapiens_hsa003501.00170435
56Vibrio cholerae infection_Homo sapiens_hsa051100.98031939
57Glutamatergic synapse_Homo sapiens_hsa047240.97815530
58RNA polymerase_Homo sapiens_hsa030200.97790168
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97713146
60Insulin secretion_Homo sapiens_hsa049110.93170968
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.92133749
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91310694
63Bile secretion_Homo sapiens_hsa049760.90396272
64Alcoholism_Homo sapiens_hsa050340.89880037
65Tryptophan metabolism_Homo sapiens_hsa003800.88589704
66Dopaminergic synapse_Homo sapiens_hsa047280.88310826
67Serotonergic synapse_Homo sapiens_hsa047260.86966980
68Ether lipid metabolism_Homo sapiens_hsa005650.86645620
69Metabolic pathways_Homo sapiens_hsa011000.83665115
70Pentose phosphate pathway_Homo sapiens_hsa000300.80460021
71Pancreatic secretion_Homo sapiens_hsa049720.80423949
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.79584783
73Circadian entrainment_Homo sapiens_hsa047130.78207851
74Dilated cardiomyopathy_Homo sapiens_hsa054140.78061627
75Taste transduction_Homo sapiens_hsa047420.77922496
76ECM-receptor interaction_Homo sapiens_hsa045120.77057915
77Amphetamine addiction_Homo sapiens_hsa050310.76475497
78Cocaine addiction_Homo sapiens_hsa050300.75657023
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74514099
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73709473
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70599071
82Glycerolipid metabolism_Homo sapiens_hsa005610.69755581
83Morphine addiction_Homo sapiens_hsa050320.68416752
84Retinol metabolism_Homo sapiens_hsa008300.66841060
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65689070
86beta-Alanine metabolism_Homo sapiens_hsa004100.65456860
87Glutathione metabolism_Homo sapiens_hsa004800.64469036
88Mismatch repair_Homo sapiens_hsa034300.62025373
89* Endocytosis_Homo sapiens_hsa041440.59302380
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.58020849
91Phenylalanine metabolism_Homo sapiens_hsa003600.57844221
92Complement and coagulation cascades_Homo sapiens_hsa046100.57333526
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55786684
94Circadian rhythm_Homo sapiens_hsa047100.55617824
95Long-term potentiation_Homo sapiens_hsa047200.55599271
96Cholinergic synapse_Homo sapiens_hsa047250.55403485
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53365453
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53087213
99Ribosome_Homo sapiens_hsa030100.52561937
100Regulation of autophagy_Homo sapiens_hsa041400.52347791
101Salivary secretion_Homo sapiens_hsa049700.52091092
102Long-term depression_Homo sapiens_hsa047300.51927226
103Fatty acid biosynthesis_Homo sapiens_hsa000610.50769835
104Sulfur relay system_Homo sapiens_hsa041220.49724664
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49336162
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49173998
107Fat digestion and absorption_Homo sapiens_hsa049750.48854911
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48630819
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47340022
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46236550
111Chemical carcinogenesis_Homo sapiens_hsa052040.44961165
112Linoleic acid metabolism_Homo sapiens_hsa005910.44566827
113Olfactory transduction_Homo sapiens_hsa047400.43503454
114Fructose and mannose metabolism_Homo sapiens_hsa000510.42009501
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.41026187
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40671004
117Oocyte meiosis_Homo sapiens_hsa041140.39155942
118PPAR signaling pathway_Homo sapiens_hsa033200.34825162
119Gap junction_Homo sapiens_hsa045400.33581616
120Gastric acid secretion_Homo sapiens_hsa049710.33138315
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32014002
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31732925
123Purine metabolism_Homo sapiens_hsa002300.30965670
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.30929866
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.30191354
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29814657
127Galactose metabolism_Homo sapiens_hsa000520.29468819

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