RAB4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.44828108
2ribosomal small subunit assembly (GO:0000028)5.11966491
3negative regulation of cell killing (GO:0031342)4.95471992
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.95471992
5viral transcription (GO:0019083)4.58360456
6G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.52655934
7translational termination (GO:0006415)4.34310643
8positive regulation of gamma-delta T cell activation (GO:0046645)4.29731773
9antigen processing and presentation of endogenous antigen (GO:0019883)4.25128342
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17375068
11immunoglobulin mediated immune response (GO:0016064)4.11644996
12DNA deamination (GO:0045006)4.09184242
13neuromuscular process controlling posture (GO:0050884)4.07588459
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02069451
15cotranslational protein targeting to membrane (GO:0006613)3.91875496
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90653044
17protein targeting to ER (GO:0045047)3.85427217
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84111623
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.84111623
20modulation by symbiont of host immune response (GO:0052553)3.84111623
21positive regulation by symbiont of host defense response (GO:0052509)3.84111623
22modulation by symbiont of host defense response (GO:0052031)3.84111623
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84111623
24protein localization to endoplasmic reticulum (GO:0070972)3.71850723
25central nervous system myelination (GO:0022010)3.66626758
26axon ensheathment in central nervous system (GO:0032291)3.66626758
27macrophage activation involved in immune response (GO:0002281)3.66339774
28negative regulation of interleukin-12 production (GO:0032695)3.65137671
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64803279
30cellular protein complex disassembly (GO:0043624)3.64551604
31translational elongation (GO:0006414)3.62033882
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58196752
33viral life cycle (GO:0019058)3.52629376
34detection of bacterium (GO:0016045)3.52400406
35detection of other organism (GO:0098543)3.48159865
36response to peptidoglycan (GO:0032494)3.44090080
37negative regulation of calcium ion transport into cytosol (GO:0010523)3.42410816
38sequestering of actin monomers (GO:0042989)3.40345078
39positive regulation of antigen processing and presentation (GO:0002579)3.38673288
40positive regulation of mast cell activation (GO:0033005)3.37455137
41regulation of antigen processing and presentation (GO:0002577)3.36670690
42protein neddylation (GO:0045116)3.33762523
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.33046477
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.32263829
45regulation of mast cell degranulation (GO:0043304)3.28275550
46interferon-gamma-mediated signaling pathway (GO:0060333)3.26291614
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25238389
48G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.23891425
49leukocyte aggregation (GO:0070486)3.22453219
50purinergic nucleotide receptor signaling pathway (GO:0035590)3.20778860
51defense response to protozoan (GO:0042832)3.20736402
52microglial cell activation (GO:0001774)3.19938902
53response to type I interferon (GO:0034340)3.15887641
54type I interferon signaling pathway (GO:0060337)3.15350000
55cellular response to type I interferon (GO:0071357)3.15350000
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.13109426
57positive regulation of mast cell degranulation (GO:0043306)3.13109426
58granulocyte activation (GO:0036230)3.12186879
59neuronal action potential propagation (GO:0019227)3.11943376
60regulation of gamma-delta T cell activation (GO:0046643)3.11848368
61regulation of mast cell activation (GO:0033003)3.10642094
62B cell mediated immunity (GO:0019724)3.09999086
63protein complex biogenesis (GO:0070271)3.07002628
64long-chain fatty acid biosynthetic process (GO:0042759)3.05561887
65regulation of mast cell activation involved in immune response (GO:0033006)3.05427417
66protein complex disassembly (GO:0043241)3.04633300
67negative regulation of leukocyte mediated immunity (GO:0002704)3.04574927
68response to protozoan (GO:0001562)3.03425997
69negative regulation of T cell mediated immunity (GO:0002710)3.03041766
70myeloid cell activation involved in immune response (GO:0002275)3.02506611
71regulation of interferon-beta biosynthetic process (GO:0045357)3.02484845
72muscle organ morphogenesis (GO:0048644)2.95468430
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93911733
74hydrogen peroxide biosynthetic process (GO:0050665)2.91309558
75mannosylation (GO:0097502)2.90070434
76negative regulation of B cell mediated immunity (GO:0002713)2.89435967
77negative regulation of immunoglobulin mediated immune response (GO:0002890)2.89435967
78macromolecular complex disassembly (GO:0032984)2.88073374
79regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86959960
80mitochondrial respiratory chain complex assembly (GO:0033108)2.86043113
81regulation of T cell mediated cytotoxicity (GO:0001914)2.85658037
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83706014
83positive thymic T cell selection (GO:0045059)2.82157211
84ear development (GO:0043583)2.80391807
85positive regulation of type 2 immune response (GO:0002830)2.79648149
86maturation of SSU-rRNA (GO:0030490)2.79403929
87regulation of natural killer cell mediated immunity (GO:0002715)2.79006155
88regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.79006155
89detection of external biotic stimulus (GO:0098581)2.78079925
90regulation of B cell receptor signaling pathway (GO:0050855)2.76357274
91negative thymic T cell selection (GO:0045060)2.75451166
92cellular extravasation (GO:0045123)2.74676224
93macrophage activation (GO:0042116)2.74338095
94regulation of leukocyte degranulation (GO:0043300)2.69508233
95purinergic receptor signaling pathway (GO:0035587)2.68951351
96cellular response to interleukin-15 (GO:0071350)2.68734807
97germinal center formation (GO:0002467)2.68128102
98response to host immune response (GO:0052572)2.68041123
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68041123
100respiratory system process (GO:0003016)2.66333542
101respiratory burst (GO:0045730)2.66324316
102response to interferon-beta (GO:0035456)2.66228812
103mast cell activation (GO:0045576)2.66018775
104regulation of T cell tolerance induction (GO:0002664)2.65736065
105protein targeting to membrane (GO:0006612)2.65550548
106regulation of gamma-delta T cell differentiation (GO:0045586)2.65414665
107NIK/NF-kappaB signaling (GO:0038061)2.64626480
108negative T cell selection (GO:0043383)2.64460426
109regulation of regulated secretory pathway (GO:1903305)2.63954303
110negative regulation of cytokine production involved in immune response (GO:0002719)2.62504920
111synaptic vesicle exocytosis (GO:0016079)2.62492560
112positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62358522
113negative regulation of innate immune response (GO:0045824)2.62256533
114positive regulation of B cell differentiation (GO:0045579)2.61596150
115neutrophil activation involved in immune response (GO:0002283)2.60986238
116neurofilament cytoskeleton organization (GO:0060052)2.60764085
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59493327
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.59493327
119NADH dehydrogenase complex assembly (GO:0010257)2.59493327
120negative regulation of erythrocyte differentiation (GO:0045647)2.59026763
121response to interleukin-15 (GO:0070672)2.58516661
122negative regulation of heart rate (GO:0010459)2.57048226
123reactive oxygen species biosynthetic process (GO:1903409)2.56831324
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56732724
125regulation of type 2 immune response (GO:0002828)2.56613084
126GPI anchor biosynthetic process (GO:0006506)2.56160081
127negative regulation of alpha-beta T cell activation (GO:0046636)2.54668104
128regulation of T-helper 2 cell differentiation (GO:0045628)2.54142067
129detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.53904024
130detection of temperature stimulus involved in sensory perception (GO:0050961)2.53904024
131activated T cell proliferation (GO:0050798)2.53805070
132translational initiation (GO:0006413)2.53596132
133regulation of leukocyte mediated cytotoxicity (GO:0001910)2.53326139
134translation (GO:0006412)2.50004634
135ncRNA 3-end processing (GO:0043628)2.49409058
136leukocyte migration involved in inflammatory response (GO:0002523)2.49382239
137regulation of tolerance induction (GO:0002643)2.49339189
138negative regulation of interleukin-6 production (GO:0032715)2.49295173
139deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.48887309
140regulation of lamellipodium assembly (GO:0010591)2.48786738
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48703812
142regulation of T-helper 1 cell differentiation (GO:0045625)2.47283511
143regulation of B cell differentiation (GO:0045577)2.47261222
144positive regulation of interleukin-17 production (GO:0032740)2.47108806
145phagosome maturation (GO:0090382)2.45437183
146respiratory electron transport chain (GO:0022904)2.44864143
147regulation of germinal center formation (GO:0002634)2.43668695
148positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.43298773
149regulation of axon regeneration (GO:0048679)2.43114388
150regulation of neuron projection regeneration (GO:0070570)2.43114388
151lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42690123
152protein localization to synapse (GO:0035418)2.42521457
153electron transport chain (GO:0022900)2.40299402
154cytochrome complex assembly (GO:0017004)2.36880044
155neuron cell-cell adhesion (GO:0007158)2.36707139
156respiratory chain complex IV assembly (GO:0008535)2.36084614
157negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.35952950
158pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.35191883
159Arp2/3 complex-mediated actin nucleation (GO:0034314)2.33253489
160negative regulation of type 2 immune response (GO:0002829)2.33027236
161establishment of mitochondrion localization (GO:0051654)2.32544441
162C-terminal protein lipidation (GO:0006501)2.30066213
163regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.29739199
164establishment or maintenance of monopolar cell polarity (GO:0061339)2.29419859
165establishment of monopolar cell polarity (GO:0061162)2.29419859
166nucleoside diphosphate catabolic process (GO:0009134)2.27149501
167negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.26917672
168ATP synthesis coupled proton transport (GO:0015986)2.26835063
169energy coupled proton transport, down electrochemical gradient (GO:0015985)2.26835063
170regulation of protein targeting to membrane (GO:0090313)2.26277698
171neurotransmitter uptake (GO:0001504)2.25005578
172peripheral nervous system neuron development (GO:0048935)2.24657932
173leukocyte degranulation (GO:0043299)2.23465439
174mast cell degranulation (GO:0043303)2.21992010
175mast cell activation involved in immune response (GO:0002279)2.21992010
176synaptic vesicle maturation (GO:0016188)2.21611732
177ribosomal large subunit biogenesis (GO:0042273)2.21093060
178pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.20222029
179GPI anchor metabolic process (GO:0006505)2.19958738
180B cell receptor signaling pathway (GO:0050853)2.18880775
181positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.18502430
182cellular component biogenesis (GO:0044085)2.16394518
183neutrophil activation (GO:0042119)2.16286051
184detection of temperature stimulus (GO:0016048)2.15123732
185transepithelial transport (GO:0070633)2.14019153
186establishment of protein localization to membrane (GO:0090150)2.13933580
187C-terminal protein amino acid modification (GO:0018410)2.13610680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.09327586
2IKZF1_21737484_ChIP-ChIP_HCT116_Human3.22329534
3EZH2_22144423_ChIP-Seq_EOC_Human2.88657257
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81806954
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71321799
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43676307
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.36980515
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.33888755
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29075286
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28404388
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.21749662
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15365172
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15365172
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15365172
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14783518
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13511169
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11268187
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05361715
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.96648759
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94812994
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94682796
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94515518
23SCL_19346495_ChIP-Seq_HPC-7_Human1.93862537
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92474367
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91477534
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90690274
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.85467778
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85017137
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83401268
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.76468554
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75179938
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72003296
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70736808
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.68739199
35CTCF_18555785_ChIP-Seq_MESCs_Mouse1.65453309
36* UTX_26944678_Chip-Seq_JUKART_Human1.64520990
37BCOR_27268052_Chip-Seq_Bcells_Human1.62653837
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62187939
39MAF_26560356_Chip-Seq_TH1_Human1.60258680
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59271895
41VDR_21846776_ChIP-Seq_THP-1_Human1.58834960
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56200452
43REST_21632747_ChIP-Seq_MESCs_Mouse1.55610313
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.52561690
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.52441654
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51716986
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48375495
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44675789
49MYB_26560356_Chip-Seq_TH2_Human1.44642307
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43739998
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43341864
52KDM2B_26808549_Chip-Seq_DND41_Human1.42798171
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.42684235
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.42644880
55STAT1_20625510_ChIP-Seq_HELA_Human1.42471205
56* P68_20966046_ChIP-Seq_HELA_Human1.41348742
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39823138
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35480387
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35026297
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34839683
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34682059
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33299894
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32872109
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32629656
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32556014
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31524088
67VDR_22108803_ChIP-Seq_LS180_Human1.31207315
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.30647359
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29822708
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29446346
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28963780
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27309169
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27077944
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.27060368
75RUNX_20019798_ChIP-Seq_JUKART_Human1.25874026
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25820825
77E2F1_20622854_ChIP-Seq_HELA_Human1.25380352
78CTCF_20526341_ChIP-Seq_ESCs_Human1.25200926
79GATA3_27048872_Chip-Seq_THYMUS_Human1.23416093
80VDR_24763502_ChIP-Seq_THP-1_Human1.21729046
81IRF1_19129219_ChIP-ChIP_H3396_Human1.21423928
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20453241
83SPI1_23547873_ChIP-Seq_NB4_Human1.18893256
84PHF8_20622854_ChIP-Seq_HELA_Human1.18069973
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17979773
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.17481382
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16531903
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16165601
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.15702401
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15136237
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15013411
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14967417
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14839006
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14579645
95ETS1_20019798_ChIP-Seq_JURKAT_Human1.14353461
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14189187
97GATA1_19941826_ChIP-Seq_K562_Human1.13920236
98P300_27268052_Chip-Seq_Bcells_Human1.13475369
99VDR_24787735_ChIP-Seq_THP-1_Human1.13033933
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12839951
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12786950
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12419264
103MYC_22102868_ChIP-Seq_BL_Human1.12004422
104* TCF7_22412390_ChIP-Seq_EML_Mouse1.11659700
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11560650
106GATA3_26560356_Chip-Seq_TH2_Human1.11365826
107SA1_27219007_Chip-Seq_Bcells_Human1.10981886
108MAF_26560356_Chip-Seq_TH2_Human1.09927018
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09607928
110BCL6_27268052_Chip-Seq_Bcells_Human1.09556624
111LXR_22292898_ChIP-Seq_THP-1_Human1.09056938
112MYB_26560356_Chip-Seq_TH1_Human1.08978639
113HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08707809
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08499173
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08322743
116OCT4_19829295_ChIP-Seq_ESCs_Human1.07825114
117* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07244942
118SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06910292
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06260141
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06022563
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.05751233
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05067878
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04985591
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04804708
125EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04643789
126* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04560597
127CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04480661
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04117335
129MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04017114
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03929432
131SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03138064
132SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03119324
133* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02677085
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.02314509
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02261056
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02004463
137SPI1_23127762_ChIP-Seq_K562_Human1.01874250
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00917307
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00703056
140SMC4_20622854_ChIP-Seq_HELA_Human1.00431291
141SPI1_20517297_ChIP-Seq_HL60_Human0.99916311
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99440335
143DROSHA_22980978_ChIP-Seq_HELA_Human0.99247885
144PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98810957
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97896562
146GBX2_23144817_ChIP-Seq_PC3_Human0.97758364
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97676048
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97628045
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94846435
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94368304
151EZH2_27304074_Chip-Seq_ESCs_Mouse0.93620431
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.93061181
153CTCF_27219007_Chip-Seq_Bcells_Human0.92282883
154RUNX1_22412390_ChIP-Seq_EML_Mouse0.89309123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.50043026
2MP0001986_abnormal_taste_sensitivity3.44227156
3MP0003880_abnormal_central_pattern2.98374448
4MP0001968_abnormal_touch/_nociception2.73697567
5MP0002735_abnormal_chemical_nociception2.69978354
6MP0002736_abnormal_nociception_after2.49174243
7MP0009379_abnormal_foot_pigmentation2.37164661
8MP0003172_abnormal_lysosome_physiology2.34077520
9MP0004859_abnormal_synaptic_plasticity2.32190033
10MP0009785_altered_susceptibility_to2.27975057
11MP0002272_abnormal_nervous_system2.22004742
12MP0001970_abnormal_pain_threshold2.17412264
13MP0005671_abnormal_response_to2.13670632
14MP0001835_abnormal_antigen_presentation2.13239494
15MP0004142_abnormal_muscle_tone2.13200976
16MP0002733_abnormal_thermal_nociception2.12565576
17MP0004270_analgesia2.10271450
18MP0005464_abnormal_platelet_physiology1.99498078
19MP0002064_seizures1.99372866
20MP0001188_hyperpigmentation1.99289595
21MP0006276_abnormal_autonomic_nervous1.96170986
22MP0005058_abnormal_lysosome_morphology1.94269451
23MP0005000_abnormal_immune_tolerance1.92239745
24MP0005423_abnormal_somatic_nervous1.92000194
25MP0001790_abnormal_immune_system1.91498178
26MP0005387_immune_system_phenotype1.91498178
27MP0009745_abnormal_behavioral_response1.90694459
28MP0002734_abnormal_mechanical_nocicepti1.88499839
29MP0000920_abnormal_myelination1.86338929
30MP0002148_abnormal_hypersensitivity_rea1.84736203
31MP0001529_abnormal_vocalization1.79546865
32MP0009046_muscle_twitch1.79472673
33MP0001800_abnormal_humoral_immune1.78969052
34MP0009764_decreased_sensitivity_to1.77681519
35MP0003635_abnormal_synaptic_transmissio1.76857213
36MP0003866_abnormal_defecation1.74808341
37MP0001905_abnormal_dopamine_level1.72692050
38MP0009278_abnormal_bone_marrow1.68904876
39MP0000685_abnormal_immune_system1.68537338
40MP0002723_abnormal_immune_serum1.65583995
41MP0003075_altered_response_to1.63264807
42MP0003724_increased_susceptibility_to1.62818387
43MP0002420_abnormal_adaptive_immunity1.61425406
44MP0005025_abnormal_response_to1.59227031
45MP0001819_abnormal_immune_cell1.57489168
46MP0010386_abnormal_urinary_bladder1.56111822
47MP0004510_myositis1.51033897
48MP0002452_abnormal_antigen_presenting1.50833705
49MP0003436_decreased_susceptibility_to1.45801377
50MP0004947_skin_inflammation1.44492173
51MP0003763_abnormal_thymus_physiology1.43401466
52MP0005645_abnormal_hypothalamus_physiol1.42713215
53MP0003303_peritoneal_inflammation1.38115299
54MP0001486_abnormal_startle_reflex1.38018982
55MP0008469_abnormal_protein_level1.36029750
56MP0002419_abnormal_innate_immunity1.35446838
57MP0002067_abnormal_sensory_capabilities1.31714178
58MP0000604_amyloidosis1.31141255
59MP0002572_abnormal_emotion/affect_behav1.30795296
60MP0003690_abnormal_glial_cell1.29827225
61MP0003300_gastrointestinal_ulcer1.27526632
62MP0003183_abnormal_peptide_metabolism1.25480423
63MP0004742_abnormal_vestibular_system1.25436557
64MP0002063_abnormal_learning/memory/cond1.24341015
65MP0008260_abnormal_autophagy1.24239823
66MP0003879_abnormal_hair_cell1.23923559
67MP0002138_abnormal_hepatobiliary_system1.23283545
68MP0001664_abnormal_digestion1.22509203
69MP0005167_abnormal_blood-brain_barrier1.21597793
70MP0005075_abnormal_melanosome_morpholog1.21192197
71MP0002933_joint_inflammation1.20186446
72MP0006292_abnormal_olfactory_placode1.20168869
73MP0005397_hematopoietic_system_phenotyp1.19241273
74MP0001545_abnormal_hematopoietic_system1.19241273
75MP0005310_abnormal_salivary_gland1.19227140
76MP0009333_abnormal_splenocyte_physiolog1.19062513
77MP0008569_lethality_at_weaning1.18114524
78MP0000716_abnormal_immune_system1.16158270
79MP0001984_abnormal_olfaction1.14435177
80MP0005171_absent_coat_pigmentation1.13410747
81MP0002184_abnormal_innervation1.12579721
82MP0006082_CNS_inflammation1.12484537
83MP0002398_abnormal_bone_marrow1.11202466
84MP0005166_decreased_susceptibility_to1.10774130
85MP0000015_abnormal_ear_pigmentation1.10142141
86MP0003136_yellow_coat_color1.08836374
87MP0009840_abnormal_foam_cell1.08682917
88MP0003191_abnormal_cellular_cholesterol1.08344472
89MP0002653_abnormal_ependyma_morphology1.07623869
90MP0004858_abnormal_nervous_system1.07212008
91MP0002751_abnormal_autonomic_nervous1.07004655
92MP0005451_abnormal_body_composition1.04906831
93MP0002229_neurodegeneration1.03526988
94MP0003329_amyloid_beta_deposits1.03398869
95MP0001663_abnormal_digestive_system1.02503887
96MP0000955_abnormal_spinal_cord1.00575866
97MP0000372_irregular_coat_pigmentation0.99941768
98MP0001501_abnormal_sleep_pattern0.98082410
99MP0005174_abnormal_tail_pigmentation0.97743420
100MP0002822_catalepsy0.97709249
101MP0002132_abnormal_respiratory_system0.96710168
102MP0002405_respiratory_system_inflammati0.96113893
103MP0001873_stomach_inflammation0.95399133
104MP0000343_altered_response_to0.95175739
105MP0003806_abnormal_nucleotide_metabolis0.93117624
106MP0002277_abnormal_respiratory_mucosa0.92826624
107MP0001440_abnormal_grooming_behavior0.92805159
108MP0005410_abnormal_fertilization0.92399839
109MP0005535_abnormal_body_temperature0.92286681
110MP0002638_abnormal_pupillary_reflex0.90859171
111MP0008874_decreased_physiological_sensi0.90809400
112MP0000689_abnormal_spleen_morphology0.90133881
113MP0000465_gastrointestinal_hemorrhage0.86425383
114MP0002998_abnormal_bone_remodeling0.85794669
115MP0010155_abnormal_intestine_physiology0.84705489
116MP0002429_abnormal_blood_cell0.84377456
117MP0002882_abnormal_neuron_morphology0.83184975
118MP0002557_abnormal_social/conspecific_i0.83044753
119MP0008004_abnormal_stomach_pH0.81862551
120MP0001845_abnormal_inflammatory_respons0.81456643
121MP0004381_abnormal_hair_follicle0.80927584
122MP0003787_abnormal_imprinting0.79988543
123MP0002066_abnormal_motor_capabilities/c0.78728077
124MP0003634_abnormal_glial_cell0.78401033
125MP0002722_abnormal_immune_system0.78335089
126MP0001348_abnormal_lacrimal_gland0.77689496
127MP0001533_abnormal_skeleton_physiology0.77295029
128MP0005390_skeleton_phenotype0.77063636
129MP0003633_abnormal_nervous_system0.76820326
130MP0005379_endocrine/exocrine_gland_phen0.76468209
131MP0008875_abnormal_xenobiotic_pharmacok0.72255315
132MP0000858_altered_metastatic_potential0.71562160
133MP0008872_abnormal_physiological_respon0.70540677
134MP0000703_abnormal_thymus_morphology0.69562442
135MP0005084_abnormal_gallbladder_morpholo0.69368303
136MP0004883_abnormal_blood_vessel0.68976426
137MP0004130_abnormal_muscle_cell0.65900436
138MP0009765_abnormal_xenobiotic_induced0.64676768

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.92610915
2Abnormal number of erythroid precursors (HP:0012131)4.82174652
3Myokymia (HP:0002411)4.48492882
4Orchitis (HP:0100796)4.41599656
5Retrobulbar optic neuritis (HP:0100654)4.21091122
6Optic neuritis (HP:0100653)4.21091122
7Elevated erythrocyte sedimentation rate (HP:0003565)3.45702848
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.44346737
9IgM deficiency (HP:0002850)3.43092982
10Stomatitis (HP:0010280)3.38033934
11Increased cerebral lipofuscin (HP:0011813)3.32540186
12Recurrent gram-negative bacterial infections (HP:0005420)3.31378927
13Abnormality of liposaccharide metabolism (HP:0010968)3.26334404
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.26334404
15Abnormality of glycolipid metabolism (HP:0010969)3.26334404
16Encephalitis (HP:0002383)3.23946539
17Increased IgE level (HP:0003212)3.23284864
18Recurrent abscess formation (HP:0002722)3.22546945
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21486742
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21486742
21Acute necrotizing encephalopathy (HP:0006965)3.19945971
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.15784369
23Abnormal mitochondria in muscle tissue (HP:0008316)3.05287735
243-Methylglutaconic aciduria (HP:0003535)2.98784233
25Reticulocytopenia (HP:0001896)2.94151212
26Mitochondrial inheritance (HP:0001427)2.93583366
27Ulnar claw (HP:0001178)2.91463922
28Prolonged bleeding time (HP:0003010)2.88937673
29Petechiae (HP:0000967)2.88023731
30Agammaglobulinemia (HP:0004432)2.87388428
31Dysostosis multiplex (HP:0000943)2.78512929
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77452362
33Keratoconjunctivitis sicca (HP:0001097)2.76391749
34Hypothermia (HP:0002045)2.73208397
35Pulmonary infiltrates (HP:0002113)2.71403273
36Gastrointestinal infarctions (HP:0005244)2.71200602
37Chronic otitis media (HP:0000389)2.70062533
38Episodic fever (HP:0001954)2.69881176
39Peripheral hypomyelination (HP:0007182)2.68932182
40Hemoptysis (HP:0002105)2.66642198
41Mutism (HP:0002300)2.63688891
42Keratoconjunctivitis (HP:0001096)2.62473316
43Meningitis (HP:0001287)2.62317342
44Purpura (HP:0000979)2.62162310
45Gastrointestinal stroma tumor (HP:0100723)2.57842395
46Eczematoid dermatitis (HP:0000976)2.57028181
47Limb dystonia (HP:0002451)2.56265121
48Type I transferrin isoform profile (HP:0003642)2.56203671
49Urticaria (HP:0001025)2.54542916
50Chronic obstructive pulmonary disease (HP:0006510)2.53315861
51Obstructive lung disease (HP:0006536)2.53315861
52Hepatocellular necrosis (HP:0001404)2.49713186
53Macrocytic anemia (HP:0001972)2.45081083
54Retinal dysplasia (HP:0007973)2.44983833
55Increased IgM level (HP:0003496)2.44236259
56Renal Fanconi syndrome (HP:0001994)2.43238671
57Recurrent bronchitis (HP:0002837)2.41839521
58Pustule (HP:0200039)2.41603490
59Progressive macrocephaly (HP:0004481)2.40779451
60Leukocytosis (HP:0001974)2.37890565
61Systemic lupus erythematosus (HP:0002725)2.36762733
62Diplopia (HP:0000651)2.35516544
63Abnormality of binocular vision (HP:0011514)2.35516544
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33845987
65Abnormality of polysaccharide metabolism (HP:0011012)2.33845987
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33845987
67Leukodystrophy (HP:0002415)2.33422957
68Supranuclear gaze palsy (HP:0000605)2.33217842
69Increased serum ferritin (HP:0003281)2.33195964
70Spontaneous hematomas (HP:0007420)2.31752975
71Ankle clonus (HP:0011448)2.29634297
72Atonic seizures (HP:0010819)2.28930222
73Recurrent viral infections (HP:0004429)2.28050505
74Autoimmune thrombocytopenia (HP:0001973)2.25185114
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23783276
76Panhypogammaglobulinemia (HP:0003139)2.21261735
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.21156531
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20545121
79Abnormality of magnesium homeostasis (HP:0004921)2.20389904
80Acute encephalopathy (HP:0006846)2.19912817
81Granulocytopenia (HP:0001913)2.19854234
82Inflammation of the large intestine (HP:0002037)2.19669703
83Recurrent bacterial skin infections (HP:0005406)2.18919399
84Sensory axonal neuropathy (HP:0003390)2.17916092
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15575341
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.15575341
87Epistaxis (HP:0000421)2.15314073
88Patchy hypopigmentation of hair (HP:0011365)2.15222899
89Increased CSF lactate (HP:0002490)2.14611134
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13558566
91Optic disc pallor (HP:0000543)2.13364194
92Hypochromic anemia (HP:0001931)2.13284346
93Poor suck (HP:0002033)2.12620575
94Chest pain (HP:0100749)2.10848824
95Parakeratosis (HP:0001036)2.10251059
96Nasal polyposis (HP:0100582)2.08371663
97Anorexia (HP:0002039)2.08048439
98Polyphagia (HP:0002591)2.08007571
99Gastrointestinal inflammation (HP:0004386)2.07489330
100Abnormality of iron homeostasis (HP:0011031)2.07065772
101Dysphonia (HP:0001618)2.06847746
102Pallor (HP:0000980)2.06678498
103Eosinophilia (HP:0001880)2.06564250
104Mucopolysacchariduria (HP:0008155)2.05518061
105Urinary glycosaminoglycan excretion (HP:0003541)2.05518061
106Pulmonary embolism (HP:0002204)2.05062174
107Abnormality of the nasal mucosa (HP:0000433)2.04666959
108Vasculitis (HP:0002633)2.04491141
109Abnormality of the pleura (HP:0002103)2.04405050
110Chronic mucocutaneous candidiasis (HP:0002728)2.04196207
111Recurrent cutaneous fungal infections (HP:0011370)2.04196207
112Focal motor seizures (HP:0011153)2.04093968
113Neuroendocrine neoplasm (HP:0100634)2.03703316
114Congenital ichthyosiform erythroderma (HP:0007431)2.03548496
115Vertigo (HP:0002321)1.99898023
116Amyloidosis (HP:0011034)1.99039115
117Papilledema (HP:0001085)1.97788866
118Split foot (HP:0001839)1.97404837
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96952111
120Acne (HP:0001061)1.96332792
121Pheochromocytoma (HP:0002666)1.96104137
122Lymphopenia (HP:0001888)1.96086076
123Papilloma (HP:0012740)1.94999955
124Verrucae (HP:0200043)1.94999955
125Gingivitis (HP:0000230)1.94854400
126Abnormality of T cell number (HP:0011839)1.94832200
127Memory impairment (HP:0002354)1.94764654
128Recurrent skin infections (HP:0001581)1.94477307
129Joint swelling (HP:0001386)1.93583545
130Microvesicular hepatic steatosis (HP:0001414)1.93536993
131Abnormality of T cells (HP:0002843)1.93392721
132Abnormality of macrophages (HP:0004311)1.93133353
133Hypergammaglobulinemia (HP:0010702)1.93030510
134Febrile seizures (HP:0002373)1.93019283
135Segmental peripheral demyelination/remyelination (HP:0003481)1.92107790
136Sepsis (HP:0100806)1.90684653
137T lymphocytopenia (HP:0005403)1.90666640
138Myositis (HP:0100614)1.89897625
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89391988
140Cerebral hypomyelination (HP:0006808)1.87898419
141Focal seizures (HP:0007359)1.87508541
142Anxiety (HP:0000739)1.84868964
143Progressive neurologic deterioration (HP:0002344)1.83652250
144Recurrent sinusitis (HP:0011108)1.81772494
145IgG deficiency (HP:0004315)1.81360763
146Recurrent fungal infections (HP:0002841)1.81254165
147Hypomagnesemia (HP:0002917)1.78764059
148Mediastinal lymphadenopathy (HP:0100721)1.78706577
149Increased hepatocellular lipid droplets (HP:0006565)1.76749787
150Upper limb muscle weakness (HP:0003484)1.75372204
151Recurrent pneumonia (HP:0006532)1.74005552
152Redundant skin (HP:0001582)1.73668047
153Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.73538547
154Hyperparathyroidism (HP:0000843)1.73411616
155Sex reversal (HP:0012245)1.73303910
156Abnormal sex determination (HP:0012244)1.73303910
157Exertional dyspnea (HP:0002875)1.73028580
158Increased serum lactate (HP:0002151)1.70936596
159Increased intramyocellular lipid droplets (HP:0012240)1.70270382
160Cellulitis (HP:0100658)1.70177725
161Esotropia (HP:0000565)1.69785668
162Respiratory failure (HP:0002878)1.69016174
163Loss of speech (HP:0002371)1.68656385
164Chronic sinusitis (HP:0011109)1.68331053
165Visual hallucinations (HP:0002367)1.66639389
166Vacuolated lymphocytes (HP:0001922)1.66492460
167Severe combined immunodeficiency (HP:0004430)1.66218713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.73188625
2TLK13.71262644
3TESK23.04452337
4MAP3K122.74027905
5CASK2.59602856
6ERN12.57227090
7NME22.39243938
8RIPK42.39195165
9PRPF4B2.25657574
10MAP4K12.25560297
11BLK2.10318103
12CDK192.10164903
13MAPKAPK32.04998611
14TAOK31.97242814
15SIK21.95810288
16MAP3K141.75084616
17VRK11.74854927
18IRAK41.67945109
19TXK1.56806460
20TAOK11.52392628
21LIMK11.50478228
22JAK31.45116512
23FES1.44882084
24MAPKAPK51.43652004
25NME11.41874659
26TNIK1.36290055
27TESK11.35763274
28UHMK11.33664175
29TNK21.29184348
30MST41.26893465
31MAP2K31.25808295
32TEC1.25365144
33SYK1.22231971
34DAPK31.17924248
35DYRK21.14605343
36CSNK1G31.14143910
37NTRK31.13941396
38MARK31.11775008
39PIM21.10015683
40ADRBK21.09797617
41TAOK21.04755740
42STK391.04218192
43GRK71.01931821
44CSF1R1.01715811
45MAPK131.01682686
46MINK11.00176085
47GRK50.99963403
48MARK20.99645746
49MAP3K30.97479354
50BTK0.97066160
51ZAP700.95363831
52MAPK150.94827550
53YES10.93485596
54KIT0.93148690
55MAP2K70.92093916
56BCKDK0.91899758
57JAK10.91008830
58RPS6KB20.89803568
59MAP3K10.89648984
60PKN10.89130724
61CLK10.89121871
62OXSR10.88511470
63MAP3K110.87881355
64JAK20.86812079
65CAMKK10.85048684
66ZAK0.84735006
67MAPK120.84087046
68CSNK1A1L0.83051295
69SIK30.82570547
70LCK0.82521877
71CAMKK20.81938755
72PDK10.81932777
73LYN0.80997648
74PTK2B0.80315395
75MAP2K60.80203144
76EIF2AK30.78054413
77ACVR1B0.76822962
78ARAF0.74310969
79IKBKB0.71811998
80DAPK20.68150336
81ROCK20.66452718
82KDR0.66265972
83NTRK20.65959284
84PRKCQ0.65421759
85TBK10.65396162
86GRK60.65326926
87DAPK10.64050282
88IKBKE0.63937150
89CSNK1G20.62953897
90HCK0.62924184
91PINK10.62653442
92CDC42BPA0.61748298
93FYN0.60641390
94ITK0.60616995
95PRKD20.60588655
96MYLK0.60073055
97PDPK10.59631806
98MAP3K130.59607588
99EPHB10.59575867
100MATK0.58685442
101CSNK1G10.58275869
102MARK10.58233156
103CAMK2B0.58038806
104MAP3K90.57793436
105NTRK10.57362904
106PRKCH0.56218268
107GRK10.56169141
108STK110.54964602
109CAMK2D0.53393214
110FGR0.53260595
111ADRBK10.52572977
112MAP2K20.52556987
113HIPK20.51548412
114MAP3K50.49919345
115MAP2K40.48813648
116CDK50.48523080
117RPS6KA50.48253227
118PRKCZ0.47965242
119PRKCE0.47666348
120CSK0.47440592
121PAK60.47347249
122CDK140.47136332
123PIM10.46610637
124TYK20.45757138
125PRKCD0.45609763
126AURKA0.45573933
127BMPR20.44542808
128EIF2AK10.43608063
129NEK60.43442385
130CAMK10.43161695
131MAP4K20.43009693
132DYRK1B0.42376936
133IRAK30.42037436
134CHUK0.37076791
135MAPK40.36934699
136KSR20.35832633
137TGFBR20.35671407
138MAPK70.35667910
139STK100.35039776
140PRKD10.34866159
141RPS6KA60.34592840

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.45977645
2Oxidative phosphorylation_Homo sapiens_hsa001903.42361982
3Parkinsons disease_Homo sapiens_hsa050122.84834188
4Staphylococcus aureus infection_Homo sapiens_hsa051502.58991825
5Primary immunodeficiency_Homo sapiens_hsa053402.38390253
6Alzheimers disease_Homo sapiens_hsa050102.32312394
7Synaptic vesicle cycle_Homo sapiens_hsa047212.19630146
8Collecting duct acid secretion_Homo sapiens_hsa049661.95888577
9Antigen processing and presentation_Homo sapiens_hsa046121.89703276
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84430067
11Huntingtons disease_Homo sapiens_hsa050161.84301762
12Taste transduction_Homo sapiens_hsa047421.82634734
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75741591
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69938273
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65496375
16Nicotine addiction_Homo sapiens_hsa050331.57123729
17Protein export_Homo sapiens_hsa030601.54140136
18Vibrio cholerae infection_Homo sapiens_hsa051101.50682230
19Proteasome_Homo sapiens_hsa030501.44468242
20B cell receptor signaling pathway_Homo sapiens_hsa046621.44344140
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43198258
22Serotonergic synapse_Homo sapiens_hsa047261.40116694
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34671204
24Rheumatoid arthritis_Homo sapiens_hsa053231.33139905
25Viral myocarditis_Homo sapiens_hsa054161.32127994
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31573856
27Toxoplasmosis_Homo sapiens_hsa051451.30731983
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.30490751
29Other glycan degradation_Homo sapiens_hsa005111.25096895
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24531146
31Morphine addiction_Homo sapiens_hsa050321.21633169
32Olfactory transduction_Homo sapiens_hsa047401.19108105
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17888709
34TNF signaling pathway_Homo sapiens_hsa046681.17687272
35RNA polymerase_Homo sapiens_hsa030201.15968052
36Allograft rejection_Homo sapiens_hsa053301.12262148
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10541959
38Influenza A_Homo sapiens_hsa051641.10173922
39Fatty acid elongation_Homo sapiens_hsa000621.09969448
40Shigellosis_Homo sapiens_hsa051311.09678424
41Hematopoietic cell lineage_Homo sapiens_hsa046401.09636086
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07597850
43Glutamatergic synapse_Homo sapiens_hsa047241.07452141
44T cell receptor signaling pathway_Homo sapiens_hsa046601.07166029
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07149774
46Leishmaniasis_Homo sapiens_hsa051401.06615866
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06432489
48GABAergic synapse_Homo sapiens_hsa047271.02845660
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01043012
50Asthma_Homo sapiens_hsa053101.00600474
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99741701
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.97249604
53Herpes simplex infection_Homo sapiens_hsa051680.97015688
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96973330
55Cardiac muscle contraction_Homo sapiens_hsa042600.95304063
56Cholinergic synapse_Homo sapiens_hsa047250.95099260
57Circadian entrainment_Homo sapiens_hsa047130.90808555
58Chemokine signaling pathway_Homo sapiens_hsa040620.89998024
59Salmonella infection_Homo sapiens_hsa051320.89320439
60Phagosome_Homo sapiens_hsa041450.89020755
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85549726
62Graft-versus-host disease_Homo sapiens_hsa053320.85245366
63Dopaminergic synapse_Homo sapiens_hsa047280.83920428
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83500691
65Phototransduction_Homo sapiens_hsa047440.83480581
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.82039759
67Acute myeloid leukemia_Homo sapiens_hsa052210.81960808
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80608933
69Alcoholism_Homo sapiens_hsa050340.79810180
70Legionellosis_Homo sapiens_hsa051340.79608581
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79006439
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74786870
73Regulation of autophagy_Homo sapiens_hsa041400.74179611
74Ether lipid metabolism_Homo sapiens_hsa005650.71876815
75Autoimmune thyroid disease_Homo sapiens_hsa053200.71619000
76Sphingolipid metabolism_Homo sapiens_hsa006000.70610468
77Long-term potentiation_Homo sapiens_hsa047200.70262092
78Hepatitis C_Homo sapiens_hsa051600.69585685
79Salivary secretion_Homo sapiens_hsa049700.68988795
80Platelet activation_Homo sapiens_hsa046110.68963113
81Sulfur relay system_Homo sapiens_hsa041220.68857816
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68553043
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.68505515
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68293112
85Lysosome_Homo sapiens_hsa041420.67887245
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66850901
87Pertussis_Homo sapiens_hsa051330.66689327
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62578914
89Ras signaling pathway_Homo sapiens_hsa040140.62541743
90Cocaine addiction_Homo sapiens_hsa050300.62173317
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61592264
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59379255
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57999355
94Amphetamine addiction_Homo sapiens_hsa050310.57847539
95Long-term depression_Homo sapiens_hsa047300.57479854
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.57301718
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57298618
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56950661
99Osteoclast differentiation_Homo sapiens_hsa043800.55676493
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54833193
101Pyrimidine metabolism_Homo sapiens_hsa002400.54303352
102Type I diabetes mellitus_Homo sapiens_hsa049400.53818986
103Measles_Homo sapiens_hsa051620.53630935
104Tuberculosis_Homo sapiens_hsa051520.53615251
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.53498604
106Insulin secretion_Homo sapiens_hsa049110.52851438
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.51968957
108Malaria_Homo sapiens_hsa051440.49374182
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49334862
110Spliceosome_Homo sapiens_hsa030400.46803367
111African trypanosomiasis_Homo sapiens_hsa051430.46436369
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.45467614
113Epstein-Barr virus infection_Homo sapiens_hsa051690.45355138
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.45234987
115VEGF signaling pathway_Homo sapiens_hsa043700.44906297
116Hepatitis B_Homo sapiens_hsa051610.44242118
117Endocytosis_Homo sapiens_hsa041440.44114459
118Gastric acid secretion_Homo sapiens_hsa049710.43610444
119Apoptosis_Homo sapiens_hsa042100.42766618
120Arachidonic acid metabolism_Homo sapiens_hsa005900.42389660
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.42383113
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.42084026
123Steroid biosynthesis_Homo sapiens_hsa001000.41703738
124N-Glycan biosynthesis_Homo sapiens_hsa005100.41443639
125Mismatch repair_Homo sapiens_hsa034300.41420884
126Linoleic acid metabolism_Homo sapiens_hsa005910.40976020
127MAPK signaling pathway_Homo sapiens_hsa040100.37783969
128Type II diabetes mellitus_Homo sapiens_hsa049300.33399489
129GnRH signaling pathway_Homo sapiens_hsa049120.32504728
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32305054
131Oxytocin signaling pathway_Homo sapiens_hsa049210.32069434
132Prolactin signaling pathway_Homo sapiens_hsa049170.31968556
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31594849
134Calcium signaling pathway_Homo sapiens_hsa040200.30791663

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