RAB4B-EGLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)4.89177660
2Arp2/3 complex-mediated actin nucleation (GO:0034314)4.86209128
3response to peptidoglycan (GO:0032494)4.51712952
4antigen processing and presentation of endogenous antigen (GO:0019883)4.35462333
5B cell mediated immunity (GO:0019724)3.96515558
6NIK/NF-kappaB signaling (GO:0038061)3.86761357
7actin nucleation (GO:0045010)3.84507972
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.83891110
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83036597
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.80735726
11positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.79446136
12negative regulation of phagocytosis (GO:0050765)3.68340292
13GDP-mannose metabolic process (GO:0019673)3.59382222
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59339173
15regulation of interferon-beta biosynthetic process (GO:0045357)3.56060565
16regulation of B cell receptor signaling pathway (GO:0050855)3.47966388
17interferon-gamma-mediated signaling pathway (GO:0060333)3.45748170
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43544723
19chaperone mediated protein folding requiring cofactor (GO:0051085)3.43399051
20negative regulation of cell killing (GO:0031342)3.40137796
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40137796
22neutrophil activation involved in immune response (GO:0002283)3.39921451
23positive regulation by symbiont of host defense response (GO:0052509)3.35677501
24modulation by symbiont of host defense response (GO:0052031)3.35677501
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35677501
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35677501
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.35677501
28modulation by symbiont of host immune response (GO:0052553)3.35677501
29respiratory burst (GO:0045730)3.35533871
30sequestering of actin monomers (GO:0042989)3.35144802
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32799547
32detection of bacterium (GO:0016045)3.32369129
33T-helper 1 type immune response (GO:0042088)3.31335053
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.30163606
35type I interferon signaling pathway (GO:0060337)3.29462882
36cellular response to type I interferon (GO:0071357)3.29462882
37positive regulation of macrophage cytokine production (GO:0060907)3.28810268
38protein maturation by protein folding (GO:0022417)3.26327373
39regulation of B cell apoptotic process (GO:0002902)3.21496102
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21419985
41response to type I interferon (GO:0034340)3.18681627
42negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.12379475
43detection of other organism (GO:0098543)3.11943051
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11159891
45negative regulation of interleukin-12 production (GO:0032695)3.11137135
46negative regulation of B cell apoptotic process (GO:0002903)3.11005855
47regulation of antigen processing and presentation (GO:0002577)3.07844158
48regulation of hexokinase activity (GO:1903299)3.03457382
49regulation of glucokinase activity (GO:0033131)3.03457382
50base-excision repair, AP site formation (GO:0006285)3.00526081
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98963762
52negative regulation of type 2 immune response (GO:0002829)2.94696739
53response to interferon-beta (GO:0035456)2.91977424
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91900487
55positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.90208182
56detection of external biotic stimulus (GO:0098581)2.89441625
57deoxyribose phosphate catabolic process (GO:0046386)2.89356844
58positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88661418
59regulation of macrophage cytokine production (GO:0010935)2.87007733
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85328958
61neutrophil activation (GO:0042119)2.82130470
62regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81515444
63regulation of T-helper 1 cell differentiation (GO:0045625)2.80069584
64galactose catabolic process (GO:0019388)2.79158584
65negative thymic T cell selection (GO:0045060)2.78744941
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77002506
67B cell receptor signaling pathway (GO:0050853)2.74911993
68positive regulation of interferon-alpha production (GO:0032727)2.74729794
69positive regulation of protein homooligomerization (GO:0032464)2.74643834
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.73499219
71positive regulation of gamma-delta T cell activation (GO:0046645)2.72408877
72regulation of memory T cell differentiation (GO:0043380)2.70412803
73detection of molecule of bacterial origin (GO:0032490)2.70237335
74deoxyribonucleotide catabolic process (GO:0009264)2.66999116
75cellular response to interferon-beta (GO:0035458)2.66731458
76regulation of T cell mediated cytotoxicity (GO:0001914)2.65531277
77pyrimidine nucleotide catabolic process (GO:0006244)2.65306444
78positive thymic T cell selection (GO:0045059)2.65025015
79regulation of interferon-alpha production (GO:0032647)2.60013785
80granulocyte activation (GO:0036230)2.58930236
81positive regulation of cytokine production involved in immune response (GO:0002720)2.58476584
82cellular response to interferon-gamma (GO:0071346)2.57599867
83response to muramyl dipeptide (GO:0032495)2.57546733
84positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54565502
85negative T cell selection (GO:0043383)2.54175199
86positive regulation of actin cytoskeleton reorganization (GO:2000251)2.53448552
87positive regulation of interferon-gamma production (GO:0032729)2.52818602
88regulation of mast cell degranulation (GO:0043304)2.51124070
89negative regulation of bone resorption (GO:0045779)2.49121290
90detection of biotic stimulus (GO:0009595)2.48837964
91regulation of interferon-gamma biosynthetic process (GO:0045072)2.48393624
92negative regulation of chemokine production (GO:0032682)2.47260064
93cobalamin metabolic process (GO:0009235)2.47169693
94leukocyte aggregation (GO:0070486)2.45241465
95regulation of interleukin-12 production (GO:0032655)2.41343140
96positive regulation of interleukin-17 production (GO:0032740)2.41302244
97positive regulation of tumor necrosis factor production (GO:0032760)2.39960854
98purine deoxyribonucleotide catabolic process (GO:0009155)2.39893337
99regulation of mitochondrial translation (GO:0070129)2.39796358
100negative regulation of innate immune response (GO:0045824)2.38645440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.67723920
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.42467875
3IRF8_21731497_ChIP-ChIP_J774_Mouse2.67903148
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63681387
5VDR_21846776_ChIP-Seq_THP-1_Human2.60335443
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59171076
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57913901
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55625951
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49645823
10MYC_22102868_ChIP-Seq_BL_Human2.44792768
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21406087
12CIITA_25753668_ChIP-Seq_RAJI_Human2.19583890
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.19379596
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17152396
15FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09903072
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09596443
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06158349
18MAF_26560356_Chip-Seq_TH1_Human2.02789337
19UTX_26944678_Chip-Seq_JUKART_Human2.01640651
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98914973
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93673511
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91459173
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84170724
24SPI1_23547873_ChIP-Seq_NB4_Human1.79776541
25MAF_26560356_Chip-Seq_TH2_Human1.79125461
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.77791510
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77531648
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76876529
29VDR_24763502_ChIP-Seq_THP-1_Human1.76230314
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74996304
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74375536
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.73299172
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.70989141
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.70225238
35LXR_22292898_ChIP-Seq_THP-1_Human1.68126838
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64499891
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62092002
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61995575
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61783728
40BCL6_27268052_Chip-Seq_Bcells_Human1.60426470
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.57312926
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54392680
43TFEB_21752829_ChIP-Seq_HELA_Human1.52567207
44BCOR_27268052_Chip-Seq_Bcells_Human1.51239036
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49323234
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46762011
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46393985
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44616433
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39519257
50XRN2_22483619_ChIP-Seq_HELA_Human1.37600484
51PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36365390
52VDR_23849224_ChIP-Seq_CD4+_Human1.35909959
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.34481526
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34441918
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34230202
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32257158
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31656835
58P68_20966046_ChIP-Seq_HELA_Human1.30947132
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30152371
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29987150
61CTCF_26484167_Chip-Seq_Bcells_Mouse1.28099777
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27866166
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27724272
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27403440
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26050237
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25840170
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.25536333
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24884606
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.22688177
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22132104
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21879895
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21741027
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.21502842
74DCP1A_22483619_ChIP-Seq_HELA_Human1.20945871
75MYB_26560356_Chip-Seq_TH2_Human1.20872718
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20401475
77MYB_26560356_Chip-Seq_TH1_Human1.19740667
78PHF8_20622854_ChIP-Seq_HELA_Human1.19281985
79TCF7_22412390_ChIP-Seq_EML_Mouse1.18436020
80GABP_19822575_ChIP-Seq_HepG2_Human1.18201497
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17768528
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17109142
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16655273
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15320853
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15281084
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15059318
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13604348
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12841612
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.12761747
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12668371
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12204697
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10548397
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10534511
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09649851
95E2F1_20622854_ChIP-Seq_HELA_Human1.09402954
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07940131
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07669767
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.07586185
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07513998
100P300_27268052_Chip-Seq_Bcells_Human1.06315665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.70295882
2MP0001835_abnormal_antigen_presentation3.31425990
3MP0003436_decreased_susceptibility_to3.12939210
4MP0005451_abnormal_body_composition2.85880665
5MP0000685_abnormal_immune_system2.81207252
6MP0001790_abnormal_immune_system2.77986041
7MP0005387_immune_system_phenotype2.77986041
8MP0005671_abnormal_response_to2.66210321
9MP0008260_abnormal_autophagy2.57242058
10MP0001800_abnormal_humoral_immune2.52576118
11MP0005000_abnormal_immune_tolerance2.47476581
12MP0002148_abnormal_hypersensitivity_rea2.47173236
13MP0005464_abnormal_platelet_physiology2.46266915
14MP0002452_abnormal_antigen_presenting2.28498094
15MP0009785_altered_susceptibility_to2.24149904
16MP0005025_abnormal_response_to2.22806073
17MP0001905_abnormal_dopamine_level2.21529730
18MP0003172_abnormal_lysosome_physiology2.20428127
19MP0002723_abnormal_immune_serum2.19020115
20MP0000465_gastrointestinal_hemorrhage2.17789423
21MP0003183_abnormal_peptide_metabolism2.14278107
22MP0005645_abnormal_hypothalamus_physiol2.12355133
23MP0002420_abnormal_adaptive_immunity2.06685585
24MP0003724_increased_susceptibility_to2.05232345
25MP0001819_abnormal_immune_cell2.05063478
26MP0002822_catalepsy1.97812485
27MP0002419_abnormal_innate_immunity1.94767072
28MP0009278_abnormal_bone_marrow1.86221958
29MP0002398_abnormal_bone_marrow1.81872324
30MP0005083_abnormal_biliary_tract1.80749499
31MP0002277_abnormal_respiratory_mucosa1.80058772
32MP0005084_abnormal_gallbladder_morpholo1.73541048
33MP0006054_spinal_hemorrhage1.67381501
34MP0000716_abnormal_immune_system1.63101614
35MP0003011_delayed_dark_adaptation1.61210324
36MP0005058_abnormal_lysosome_morphology1.60458488
37MP0010155_abnormal_intestine_physiology1.60436178
38MP0001845_abnormal_inflammatory_respons1.53432559
39MP0000689_abnormal_spleen_morphology1.52320962
40MP0009764_decreased_sensitivity_to1.47553687
41MP0002722_abnormal_immune_system1.46255224
42MP0003763_abnormal_thymus_physiology1.44383827
43MP0003866_abnormal_defecation1.44058093
44MP0002429_abnormal_blood_cell1.40549331
45MP0000015_abnormal_ear_pigmentation1.39801221
46MP0005397_hematopoietic_system_phenotyp1.37427901
47MP0001545_abnormal_hematopoietic_system1.37427901
48MP0008469_abnormal_protein_level1.32287430
49MP0002138_abnormal_hepatobiliary_system1.32047761
50MP0006035_abnormal_mitochondrial_morpho1.31987376
51MP0002102_abnormal_ear_morphology1.28317367
52MP0003300_gastrointestinal_ulcer1.24526869
53MP0001542_abnormal_bone_strength1.24103553
54MP0000490_abnormal_crypts_of1.22646223
55MP0004510_myositis1.22421674
56MP0001533_abnormal_skeleton_physiology1.20845786
57MP0006082_CNS_inflammation1.19985406
58MP0000858_altered_metastatic_potential1.17641959
59MP0004947_skin_inflammation1.17342413
60MP0001529_abnormal_vocalization1.16202201
61MP0000569_abnormal_digit_pigmentation1.15411873
62MP0003806_abnormal_nucleotide_metabolis1.14104116
63MP0002132_abnormal_respiratory_system1.13381375
64MP0005310_abnormal_salivary_gland1.13338438
65MP0003191_abnormal_cellular_cholesterol1.12613082
66MP0009840_abnormal_foam_cell1.12080179
67MP0000343_altered_response_to1.11923263
68MP0002405_respiratory_system_inflammati1.07690258
69MP0003075_altered_response_to1.05557250
70MP0005167_abnormal_blood-brain_barrier1.00332017
71MP0000703_abnormal_thymus_morphology0.98178414
72MP0001727_abnormal_embryo_implantation0.95681883
73MP0009333_abnormal_splenocyte_physiolog0.93926332
74MP0003091_abnormal_cell_migration0.93718146
75MP0001756_abnormal_urination0.93431984
76MP0005220_abnormal_exocrine_pancreas0.91297992
77MP0004883_abnormal_blood_vessel0.90820664
78MP0002693_abnormal_pancreas_physiology0.87928838
79MP0000358_abnormal_cell_content/0.87417667
80MP0005166_decreased_susceptibility_to0.86835342
81MP0001348_abnormal_lacrimal_gland0.83555636
82MP0001663_abnormal_digestive_system0.82584884
83MP0005085_abnormal_gallbladder_physiolo0.78989752
84MP0002163_abnormal_gland_morphology0.76619438
85MP0003279_aneurysm0.75449238
86MP0009763_increased_sensitivity_to0.73836646
87MP0005390_skeleton_phenotype0.73193666
88MP0002735_abnormal_chemical_nociception0.72514498
89MP0000538_abnormal_urinary_bladder0.71773215
90MP0000371_diluted_coat_color0.70519077
91MP0002019_abnormal_tumor_incidence0.69784239
92MP0006036_abnormal_mitochondrial_physio0.69399968
93MP0003656_abnormal_erythrocyte_physiolo0.67905109
94MP0008874_decreased_physiological_sensi0.67227926
95MP0003453_abnormal_keratinocyte_physiol0.66057927
96MP0001986_abnormal_taste_sensitivity0.65983038
97MP0005501_abnormal_skin_physiology0.65753900
98MP0005584_abnormal_enzyme/coenzyme_acti0.65618823
99MP0003221_abnormal_cardiomyocyte_apopto0.65358251
100MP0002089_abnormal_postnatal_growth/wei0.63421333

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)3.93091927
2Petechiae (HP:0000967)3.85746252
3Recurrent bacterial skin infections (HP:0005406)3.79044679
4Abnormality of macrophages (HP:0004311)3.73497428
5Recurrent abscess formation (HP:0002722)3.66727270
6Elevated erythrocyte sedimentation rate (HP:0003565)3.55332354
7Generalized aminoaciduria (HP:0002909)3.24862657
8Hemorrhage of the eye (HP:0011885)3.19801980
9Agammaglobulinemia (HP:0004432)3.19762859
10Increased IgM level (HP:0003496)3.19496680
11Meningitis (HP:0001287)3.09714861
12Testicular atrophy (HP:0000029)3.09152030
13Vasculitis (HP:0002633)3.06492399
14Exertional dyspnea (HP:0002875)3.04829160
15Obstructive lung disease (HP:0006536)3.02220620
16Chronic obstructive pulmonary disease (HP:0006510)3.02220620
17Abnormal gallbladder physiology (HP:0012438)2.95844826
18Cholecystitis (HP:0001082)2.95844826
19Hepatic necrosis (HP:0002605)2.89743663
20Chest pain (HP:0100749)2.82865179
21Eczematoid dermatitis (HP:0000976)2.81911445
22Cellulitis (HP:0100658)2.80093001
23Mediastinal lymphadenopathy (HP:0100721)2.79770366
24Renal Fanconi syndrome (HP:0001994)2.78232968
25Increased hepatocellular lipid droplets (HP:0006565)2.77435209
26Epistaxis (HP:0000421)2.77175694
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76969463
28Prolonged neonatal jaundice (HP:0006579)2.73280588
29Dry hair (HP:0011359)2.68659276
30Increased intramyocellular lipid droplets (HP:0012240)2.68411161
31Gastrointestinal inflammation (HP:0004386)2.64002649
32Inflammation of the large intestine (HP:0002037)2.63951258
33Lipid accumulation in hepatocytes (HP:0006561)2.61260603
34Gingival bleeding (HP:0000225)2.58379061
35Rough bone trabeculation (HP:0100670)2.57103223
36Recurrent skin infections (HP:0001581)2.56523173
37Recurrent bronchitis (HP:0002837)2.54871074
38Myositis (HP:0100614)2.54578961
39Hypertensive crisis (HP:0100735)2.54209597
40Increased muscle lipid content (HP:0009058)2.52594964
41Urticaria (HP:0001025)2.51944165
42Papilloma (HP:0012740)2.51669149
43Verrucae (HP:0200043)2.51669149
44Abnormality of glycolipid metabolism (HP:0010969)2.41839842
45Abnormality of liposaccharide metabolism (HP:0010968)2.41839842
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.41839842
47Abnormal pupillary function (HP:0007686)2.41718931
48Acute hepatic failure (HP:0006554)2.41596605
49Prolonged bleeding time (HP:0003010)2.41087334
50Hepatocellular necrosis (HP:0001404)2.36125143
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35164707
52Abnormal trabecular bone morphology (HP:0100671)2.30950521
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.29782558
54Gastrointestinal stroma tumor (HP:0100723)2.22101248
55Purpura (HP:0000979)2.20008875
56Amaurosis fugax (HP:0100576)2.18567493
57Stomatitis (HP:0010280)2.16681129
58IgG deficiency (HP:0004315)2.16510216
59Hypergammaglobulinemia (HP:0010702)2.14413883
60Chronic sinusitis (HP:0011109)2.14074345
61Chronic mucocutaneous candidiasis (HP:0002728)2.12261577
62Recurrent cutaneous fungal infections (HP:0011370)2.12261577
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11520459
64Abnormality of polysaccharide metabolism (HP:0011012)2.11520459
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11520459
66Lymphopenia (HP:0001888)2.10986906
67Hypothermia (HP:0002045)2.09644438
68Peritonitis (HP:0002586)2.09488772
69Recurrent sinusitis (HP:0011108)2.06233533
70Poikiloderma (HP:0001029)2.05530524
71Recurrent fungal infections (HP:0002841)2.05283173
72Spontaneous hematomas (HP:0007420)2.04987501
73Glycosuria (HP:0003076)2.04664917
74Abnormality of urine glucose concentration (HP:0011016)2.04664917
75Squamous cell carcinoma (HP:0002860)2.03055553
76Mitochondrial inheritance (HP:0001427)2.02233214
77Encephalitis (HP:0002383)2.00412036
78Increased serum ferritin (HP:0003281)1.99205552
79Nausea (HP:0002018)1.96699629
80Abnormality of fatty-acid metabolism (HP:0004359)1.96373478
81Zonular cataract (HP:0010920)1.96371303
82Polyphagia (HP:0002591)1.96306921
83Mucopolysacchariduria (HP:0008155)1.95830409
84Urinary glycosaminoglycan excretion (HP:0003541)1.95830409
85Recurrent pneumonia (HP:0006532)1.94990959
86Dicarboxylic aciduria (HP:0003215)1.94267401
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94267401
88Recurrent lower respiratory tract infections (HP:0002783)1.91299910
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.90919359
90Recurrent gram-negative bacterial infections (HP:0005420)1.90479019
91Renal cortical cysts (HP:0000803)1.89652035
92Facial diplegia (HP:0001349)1.87657340
93Sepsis (HP:0100806)1.87004762
94Restrictive lung disease (HP:0002091)1.86052991
95Basal cell carcinoma (HP:0002671)1.85810003
96Skin rash (HP:0000988)1.85524037
97Colitis (HP:0002583)1.85437393
98Orchitis (HP:0100796)1.84806629
99Pulmonary fibrosis (HP:0002206)1.84307689
100Cerebral ischemia (HP:0002637)1.83611193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.24323701
2BLK2.99048229
3BCKDK2.91958483
4TLK12.89378371
5RIPK42.87113717
6VRK22.84435856
7ZAK2.56524752
8TESK12.51727648
9MAP4K12.39634433
10TBK12.37320234
11GRK62.34041138
12VRK12.25600045
13ERN12.15909231
14IRAK42.09318972
15MAP2K72.07638285
16KDR1.91376201
17ARAF1.85842056
18PRPF4B1.77131056
19TAOK11.74810667
20TAOK21.72722287
21TYK21.68862227
22MAP2K31.66022773
23SIK31.61757883
24JAK31.57878966
25IKBKB1.56646983
26CSK1.49151884
27DYRK31.44740205
28IKBKE1.42447646
29MAPK151.42050791
30ZAP701.38511907
31DAPK31.27892828
32MAP3K51.26507506
33RPS6KA51.24988874
34FES1.23137714
35PIM21.21061076
36MAP3K31.19100693
37LYN1.18712051
38DYRK1B1.17873628
39MAP4K21.17460466
40SYK1.14926870
41MAP3K41.13676542
42MAP3K141.13529990
43BMPR21.13199291
44PTK2B1.12624137
45CHUK1.09863521
46CSF1R1.04947530
47DAPK11.02648734
48MOS1.02111306
49MAP3K111.01628820
50TNK20.95679242
51IRAK30.95221942
52LIMK10.93907329
53SIK10.91470782
54MAP3K130.90812679
55MAP3K100.90269619
56MAPKAPK30.87917801
57TAOK30.85416319
58ADRBK20.85066037
59CSNK1G30.82449928
60BTK0.80696548
61RPS6KA40.79949609
62KIT0.78640197
63LMTK20.75672910
64PIM10.75307198
65PAK10.71642696
66RAF10.71355662
67MAP2K40.68781214
68SIK20.63483582
69CSNK1G20.63448556
70HCK0.62480001
71LCK0.60786688
72AURKA0.60378336
73TRIM280.58362846
74EPHB10.55621368
75CSNK1A1L0.54423812
76PIK3CG0.53197978
77GRK70.52173120
78TAF10.51920245
79ILK0.51289581
80DYRK20.50760643
81FYN0.50157198
82JAK10.46869607
83MST40.44216730
84MUSK0.44137827
85MAP3K60.43308931
86PAK40.41978701
87FGR0.41723208
88PRKCD0.39852079
89CDK140.39341688
90STK40.38699246
91HIPK20.34698293
92CDK150.33717478
93CDK180.33231572
94TXK0.32047367
95MAPK70.31802208
96CSNK1G10.30678646
97ITK0.30549050
98CDK11A0.29493959
99IRAK20.27871738
100JAK20.27840279

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.43952312
2Systemic lupus erythematosus_Homo sapiens_hsa053223.37494111
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.23324045
4Autoimmune thyroid disease_Homo sapiens_hsa053203.12166805
5Asthma_Homo sapiens_hsa053103.06687465
6Primary immunodeficiency_Homo sapiens_hsa053402.96199985
7Graft-versus-host disease_Homo sapiens_hsa053322.96160997
8Type I diabetes mellitus_Homo sapiens_hsa049402.82502126
9Leishmaniasis_Homo sapiens_hsa051402.64499038
10Proteasome_Homo sapiens_hsa030502.51972319
11Viral myocarditis_Homo sapiens_hsa054162.40919516
12Shigellosis_Homo sapiens_hsa051312.12778010
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.12021130
14Phagosome_Homo sapiens_hsa041452.10114211
15Antigen processing and presentation_Homo sapiens_hsa046122.08071418
16Alcoholism_Homo sapiens_hsa050342.01384967
17Rheumatoid arthritis_Homo sapiens_hsa053231.95280020
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74297964
19Staphylococcus aureus infection_Homo sapiens_hsa051501.73933607
20Tuberculosis_Homo sapiens_hsa051521.73352646
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72693289
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.68871235
23Herpes simplex infection_Homo sapiens_hsa051681.66939245
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55561899
25Hematopoietic cell lineage_Homo sapiens_hsa046401.54838015
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50328569
27Influenza A_Homo sapiens_hsa051641.47883010
28B cell receptor signaling pathway_Homo sapiens_hsa046621.45199713
29Toxoplasmosis_Homo sapiens_hsa051451.38045698
30Salmonella infection_Homo sapiens_hsa051321.35448792
31Osteoclast differentiation_Homo sapiens_hsa043801.30374550
32Epstein-Barr virus infection_Homo sapiens_hsa051691.28884984
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24475394
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24360070
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23861873
36Base excision repair_Homo sapiens_hsa034101.22512553
37Sulfur metabolism_Homo sapiens_hsa009201.20799593
38Other glycan degradation_Homo sapiens_hsa005111.16895417
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.14696171
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14477688
41Vibrio cholerae infection_Homo sapiens_hsa051101.14155305
42Fructose and mannose metabolism_Homo sapiens_hsa000511.09218170
43Collecting duct acid secretion_Homo sapiens_hsa049661.08046221
44Regulation of autophagy_Homo sapiens_hsa041401.07800129
45Oxidative phosphorylation_Homo sapiens_hsa001901.06682644
46Viral carcinogenesis_Homo sapiens_hsa052031.06552248
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.03082910
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01799577
49Apoptosis_Homo sapiens_hsa042100.99042619
50Lysosome_Homo sapiens_hsa041420.98959260
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93998135
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90421372
53Galactose metabolism_Homo sapiens_hsa000520.89982418
54Measles_Homo sapiens_hsa051620.89895802
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84719566
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84538648
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79493763
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79100248
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78008402
60Legionellosis_Homo sapiens_hsa051340.76927447
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76793574
62Endocytosis_Homo sapiens_hsa041440.69118289
63Hepatitis C_Homo sapiens_hsa051600.66099374
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63980408
65Pertussis_Homo sapiens_hsa051330.62524468
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62459724
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61563659
68Malaria_Homo sapiens_hsa051440.60533121
69Hepatitis B_Homo sapiens_hsa051610.58917944
70Parkinsons disease_Homo sapiens_hsa050120.56503203
71Pentose phosphate pathway_Homo sapiens_hsa000300.56220113
72Synaptic vesicle cycle_Homo sapiens_hsa047210.55966241
73Chemokine signaling pathway_Homo sapiens_hsa040620.54825569
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53911530
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52923357
76Phenylalanine metabolism_Homo sapiens_hsa003600.51375067
77Sulfur relay system_Homo sapiens_hsa041220.46064605
78TNF signaling pathway_Homo sapiens_hsa046680.45505041
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43146492
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42498784
81HTLV-I infection_Homo sapiens_hsa051660.40428315
82T cell receptor signaling pathway_Homo sapiens_hsa046600.40123615
83Platelet activation_Homo sapiens_hsa046110.38421419
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.36629736
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.36403551
86N-Glycan biosynthesis_Homo sapiens_hsa005100.32951987
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32675510
88Alzheimers disease_Homo sapiens_hsa050100.32671647
89African trypanosomiasis_Homo sapiens_hsa051430.29697264
90Huntingtons disease_Homo sapiens_hsa050160.29449116
91Biosynthesis of amino acids_Homo sapiens_hsa012300.29262852
92Acute myeloid leukemia_Homo sapiens_hsa052210.26511147
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.25237566
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.20641597
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.20470619
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19028934
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18445624
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17937918
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17009386
100Spliceosome_Homo sapiens_hsa030400.15133883

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