RAB5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.49098855
2central nervous system myelination (GO:0022010)4.49098855
3regulation of fever generation (GO:0031620)4.26835675
4membrane budding (GO:0006900)4.22782073
5Golgi transport vesicle coating (GO:0048200)3.91931001
6COPI coating of Golgi vesicle (GO:0048205)3.91931001
7fatty acid elongation (GO:0030497)3.89242073
8negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.74005984
9neuronal action potential propagation (GO:0019227)3.59992101
10protein localization to endosome (GO:0036010)3.59299713
11COPII vesicle coating (GO:0048208)3.50504914
12alpha-linolenic acid metabolic process (GO:0036109)3.47622318
13negative regulation of neurotransmitter secretion (GO:0046929)3.39596170
14cullin deneddylation (GO:0010388)3.38743548
15cell adhesion mediated by integrin (GO:0033627)3.36579587
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28480498
17ensheathment of neurons (GO:0007272)3.25738111
18axon ensheathment (GO:0008366)3.25738111
19proteasome assembly (GO:0043248)3.25598163
20synaptic vesicle maturation (GO:0016188)3.25099949
21myelination (GO:0042552)3.24481139
22negative regulation of neurotransmitter transport (GO:0051589)3.23577114
23protein deneddylation (GO:0000338)3.23249402
24cellular potassium ion homeostasis (GO:0030007)3.18344454
25cellular response to leptin stimulus (GO:0044320)3.16675691
26vesicle coating (GO:0006901)3.15449950
27synaptic vesicle exocytosis (GO:0016079)3.15042446
28linoleic acid metabolic process (GO:0043651)3.14911242
29skin morphogenesis (GO:0043589)3.07891023
30* regulation of synaptic vesicle exocytosis (GO:2000300)3.04220205
31negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.04032183
32long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.02035664
33positive regulation of heat generation (GO:0031652)3.01474727
34glutamate secretion (GO:0014047)3.01047754
35mating behavior (GO:0007617)2.99015081
36regulation of podosome assembly (GO:0071801)2.96446401
37clathrin coat assembly (GO:0048268)2.94884728
38Rap protein signal transduction (GO:0032486)2.93678455
39L-amino acid import (GO:0043092)2.92416967
40cellular protein complex localization (GO:0034629)2.92388360
41neuromuscular process controlling posture (GO:0050884)2.91552154
42positive regulation of protein autophosphorylation (GO:0031954)2.88757281
43myelin maintenance (GO:0043217)2.88542693
44regulation of heat generation (GO:0031650)2.87247861
45membrane invagination (GO:0010324)2.86946420
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.84134877
47positive regulation of actin filament depolymerization (GO:0030836)2.82968766
48negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.81706351
49fatty-acyl-CoA biosynthetic process (GO:0046949)2.81365702
50cerebellar granule cell differentiation (GO:0021707)2.81281078
51negative regulation of inclusion body assembly (GO:0090084)2.81075550
52nerve growth factor signaling pathway (GO:0038180)2.78980294
53positive regulation of glycoprotein metabolic process (GO:1903020)2.77077153
54regulation of cytokine secretion involved in immune response (GO:0002739)2.77006798
55sodium ion export (GO:0071436)2.76601054
56locomotory exploration behavior (GO:0035641)2.75393161
57asymmetric protein localization (GO:0008105)2.75262999
58regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.74961811
59positive regulation of macroautophagy (GO:0016239)2.73308309
60establishment of mitochondrion localization (GO:0051654)2.72456078
61ganglion development (GO:0061548)2.72337565
62regulation of cAMP-dependent protein kinase activity (GO:2000479)2.70259431
63regulation of vitamin D biosynthetic process (GO:0060556)2.70193062
64positive regulation of cellular amide metabolic process (GO:0034250)2.70098761
65response to leptin (GO:0044321)2.69669405
66vesicle transport along microtubule (GO:0047496)2.69219280
67organelle transport along microtubule (GO:0072384)2.66753542
68apical protein localization (GO:0045176)2.66742927
69thioester biosynthetic process (GO:0035384)2.66595530
70acyl-CoA biosynthetic process (GO:0071616)2.66595530
71magnesium ion transport (GO:0015693)2.65112112
72establishment of integrated proviral latency (GO:0075713)2.64877803
73long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.64770645
74Golgi to plasma membrane protein transport (GO:0043001)2.64187317
75regulation of collateral sprouting (GO:0048670)2.64127631
76long-chain fatty acid biosynthetic process (GO:0042759)2.62317199
77negative regulation of protein localization to plasma membrane (GO:1903077)2.62275972
78peptidyl-cysteine modification (GO:0018198)2.59580451
79branching involved in labyrinthine layer morphogenesis (GO:0060670)2.59136500
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.57649969
81sterol biosynthetic process (GO:0016126)2.56413863
82gamma-aminobutyric acid transport (GO:0015812)2.56357737
83transmission of nerve impulse (GO:0019226)2.55070059
84regulation of mononuclear cell migration (GO:0071675)2.54102634
85response to methylmercury (GO:0051597)2.53395367
86establishment of viral latency (GO:0019043)2.53237094
87activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.52905164
88* regulation of synaptic vesicle transport (GO:1902803)2.51810004
89layer formation in cerebral cortex (GO:0021819)2.51265493
90macroautophagy (GO:0016236)2.50965198
91creatine metabolic process (GO:0006600)2.49369295
92negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.48871134
93neuron cell-cell adhesion (GO:0007158)2.48749310
94dendritic spine morphogenesis (GO:0060997)2.48016121
95fatty-acyl-CoA metabolic process (GO:0035337)2.47847836
96establishment of melanosome localization (GO:0032401)2.47831349
97phagocytosis, engulfment (GO:0006911)2.46878048
98response to lipoprotein particle (GO:0055094)2.45715354
99acidic amino acid transport (GO:0015800)2.45411443
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43880992
101positive regulation of autophagy (GO:0010508)2.43437947
102positive regulation of toll-like receptor signaling pathway (GO:0034123)2.43311397
103neuron remodeling (GO:0016322)2.42489092
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.42352668
105L-phenylalanine catabolic process (GO:0006559)2.42352668
106regulation of clathrin-mediated endocytosis (GO:2000369)2.42248239
107negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.41375587
108cell fate commitment involved in formation of primary germ layer (GO:0060795)2.41299153
109peptidyl-threonine dephosphorylation (GO:0035970)2.41092246
110establishment of pigment granule localization (GO:0051905)2.40853226
111amino acid import (GO:0043090)2.40152521
112glucosamine-containing compound catabolic process (GO:1901072)2.38998019
113regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.38718255
114neuromuscular process controlling balance (GO:0050885)2.38054446
115nucleotide-sugar biosynthetic process (GO:0009226)2.37369679
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.37144240
117ER to Golgi vesicle-mediated transport (GO:0006888)2.36105918
118regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.35740215
119L-glutamate transport (GO:0015813)2.35307653
120sequestering of metal ion (GO:0051238)2.35149510
121melanosome transport (GO:0032402)2.34603633
122cellular copper ion homeostasis (GO:0006878)2.33118432
123retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32689545
124neurotransmitter secretion (GO:0007269)2.32544113
125potassium ion homeostasis (GO:0055075)2.32039491
126neuron recognition (GO:0008038)2.31643723
127endoplasmic reticulum organization (GO:0007029)2.31357952
128regulation of neuronal synaptic plasticity (GO:0048168)2.30987956
129regulation of integrin-mediated signaling pathway (GO:2001044)2.30704053
130positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.29993573
131regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.29222592
132neurotransmitter catabolic process (GO:0042135)2.28909773
133positive regulation of nitric oxide biosynthetic process (GO:0045429)2.28107351
134pigment granule transport (GO:0051904)2.27909582
135localization within membrane (GO:0051668)2.27584821
136potassium ion import (GO:0010107)2.27389697
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27387568
138transcytosis (GO:0045056)2.26863888
139regulation of Rac protein signal transduction (GO:0035020)2.26522352
140CDP-diacylglycerol metabolic process (GO:0046341)2.25544534
141regulation of early endosome to late endosome transport (GO:2000641)2.25499436
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25239319
143ribosome assembly (GO:0042255)2.25214359
144negative regulation of DNA recombination (GO:0045910)2.24409478
145ER overload response (GO:0006983)2.24346754
146protein maturation by protein folding (GO:0022417)2.23836532
147long term synaptic depression (GO:0060292)2.23668413
148negative regulation of NF-kappaB import into nucleus (GO:0042347)2.23492556
149labyrinthine layer development (GO:0060711)2.22982660
150cholesterol biosynthetic process (GO:0006695)2.22567564
151cysteine metabolic process (GO:0006534)2.21562361
152eosinophil chemotaxis (GO:0048245)2.21348070
153negative regulation of receptor-mediated endocytosis (GO:0048261)2.21188347
154very long-chain fatty acid metabolic process (GO:0000038)2.21001978
155protein complex localization (GO:0031503)2.20551964
156L-phenylalanine metabolic process (GO:0006558)2.19821756
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.19821756
158regulation of membrane protein ectodomain proteolysis (GO:0051043)2.19692742
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.18928787
160response to nerve growth factor (GO:1990089)2.17826213
161cellular response to nerve growth factor stimulus (GO:1990090)2.17826213
162regulation of chemokine-mediated signaling pathway (GO:0070099)2.17799106
163regulation of amyloid precursor protein catabolic process (GO:1902991)2.17757551
164glycerophospholipid catabolic process (GO:0046475)2.17272070
165mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.16981161
166regulation of transforming growth factor beta1 production (GO:0032908)2.16904497
167intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.16621498
168positive regulation of glycoprotein biosynthetic process (GO:0010560)2.16459646
169triglyceride biosynthetic process (GO:0019432)2.16431457
170negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.16339932
171presynaptic membrane assembly (GO:0097105)2.14994037
172positive regulation of interleukin-6 production (GO:0032755)2.14714517
173lung-associated mesenchyme development (GO:0060484)2.14559301
174activation of protein kinase A activity (GO:0034199)2.14500025
175positive regulation of vesicle fusion (GO:0031340)2.14457033
176regulation of vesicle fusion (GO:0031338)2.14241667
177dendrite morphogenesis (GO:0048813)2.14083724
178intestinal epithelial cell development (GO:0060576)2.13250422
179neutral lipid biosynthetic process (GO:0046460)2.13141828
180acylglycerol biosynthetic process (GO:0046463)2.13141828
181protein targeting to Golgi (GO:0000042)2.12440541
182autophagic vacuole assembly (GO:0000045)2.12145741
183positive regulation of potassium ion transport (GO:0043268)2.11971346
184regulation of long-term neuronal synaptic plasticity (GO:0048169)2.11321242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human3.03518613
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83214713
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.47171442
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.45321304
5PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.43512827
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.32167876
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25501609
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16908132
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16409454
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.13725863
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03521206
12ELK1_19687146_ChIP-ChIP_HELA_Human2.00209074
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.99912000
14CLOCK_20551151_ChIP-Seq_293T_Human1.98277951
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96913992
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.93063543
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86677027
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84394314
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82769674
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81502268
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76258356
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75452831
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75350259
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75333803
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74310531
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72064547
27AR_21572438_ChIP-Seq_LNCaP_Human1.70165636
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.67015802
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.64774693
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64101653
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64101653
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63482263
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61976606
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60912127
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60912127
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60363181
37AR_21909140_ChIP-Seq_LNCAP_Human1.60203121
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.59339005
39* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59325718
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58628420
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58437212
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.56276056
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.56167371
44TAF15_26573619_Chip-Seq_HEK293_Human1.54422833
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.53231766
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51376665
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50402516
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48590748
49P300_19829295_ChIP-Seq_ESCs_Human1.48514714
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47532632
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47480500
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46717321
53REST_21632747_ChIP-Seq_MESCs_Mouse1.45783554
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.44974027
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44880842
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44058241
57BRD4_25478319_ChIP-Seq_HGPS_Human1.43047607
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41065406
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39518292
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36465394
61CJUN_26792858_Chip-Seq_BT549_Human1.35565523
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34696713
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33597844
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.33119348
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32884891
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32707796
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32264910
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.31634147
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31092930
70* TFEB_21752829_ChIP-Seq_HELA_Human1.29103174
71* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29002781
72RXR_22108803_ChIP-Seq_LS180_Human1.27719041
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27644205
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.27442904
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27357578
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.26495872
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.25400056
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.25383006
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25236480
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25236480
81ZNF274_21170338_ChIP-Seq_K562_Hela1.25208576
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25128754
83TP53_16413492_ChIP-PET_HCT116_Human1.24189064
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.23497486
85GBX2_23144817_ChIP-Seq_PC3_Human1.22821820
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22213555
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.21954429
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21227603
89BCAT_22108803_ChIP-Seq_LS180_Human1.21047088
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20450049
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.20032239
92SOX2_20726797_ChIP-Seq_SW620_Human1.19717023
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.19705331
94EZH2_22144423_ChIP-Seq_EOC_Human1.19203308
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18842899
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17813021
97* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17462806
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17462789
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16670329
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16416091
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16406807
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14675366
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.14065385
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13509321
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.12552717
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11121575
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10901751
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10544761
109* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10514031
110VDR_22108803_ChIP-Seq_LS180_Human1.10082094
111TP53_18474530_ChIP-ChIP_U2OS_Human1.08631089
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08135493
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07991331
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07962950
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07792750
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07698625
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.07078567
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06574842
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06089603
120CDX2_22108803_ChIP-Seq_LS180_Human1.06004604
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04905414
122EOMES_21245162_ChIP-Seq_HESCs_Human1.04761410
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02736618
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.02404103
125FUS_26573619_Chip-Seq_HEK293_Human1.02148017
126IGF1R_20145208_ChIP-Seq_DFB_Human1.02126666
127* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01230878
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01092336
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00412757
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00250182
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99813419
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.99521150
133KDM2B_26808549_Chip-Seq_K562_Human0.98799452
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98547126
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98478452
136NANOG_16518401_ChIP-PET_MESCs_Mouse0.98197135
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98038629
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97761763
139P53_22387025_ChIP-Seq_ESCs_Mouse0.97474346
140IRF8_27001747_Chip-Seq_BMDM_Mouse0.97297020
141SMAD4_21799915_ChIP-Seq_A2780_Human0.96808020
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96017836
143* NANOG_16153702_ChIP-ChIP_HESCs_Human0.96014194
144HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95727084
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95686326
146AR_25329375_ChIP-Seq_VCAP_Human0.95652059
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.94774984
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94210801
149WT1_19549856_ChIP-ChIP_CCG9911_Human0.94021617
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.93763723
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93558939
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92190745
153AHR_22903824_ChIP-Seq_MCF-7_Human0.92122615
154TP63_23658742_ChIP-Seq_EP156T_Human0.91742204
155P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91587266
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89651007
157KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87074464
158KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87074464
159KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87074464
160ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86878874
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.86635089
162RING1B_27294783_Chip-Seq_NPCs_Mouse0.86390727
163PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85878932
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85824330
165ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85806567
166SMAD_19615063_ChIP-ChIP_OVARY_Human0.85039971
167FOXA1_25552417_ChIP-Seq_VCAP_Human0.84904797
168FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84884350
169TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84651486
170RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84611283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps4.40140786
2MP0006054_spinal_hemorrhage3.95594200
3MP0003329_amyloid_beta_deposits3.57663944
4MP0004270_analgesia3.36521170
5MP0004859_abnormal_synaptic_plasticity3.32770399
6MP0010234_abnormal_vibrissa_follicle3.31867389
7MP0003941_abnormal_skin_development3.27077683
8MP0003880_abnormal_central_pattern3.14172759
9MP0000920_abnormal_myelination2.59015617
10MP0003303_peritoneal_inflammation2.58440462
11MP0000013_abnormal_adipose_tissue2.48105836
12MP0003635_abnormal_synaptic_transmissio2.40473114
13MP0003690_abnormal_glial_cell2.36136661
14MP0002332_abnormal_exercise_endurance2.29649930
15MP0000604_amyloidosis2.28466108
16MP0003221_abnormal_cardiomyocyte_apopto2.26574554
17MP0002064_seizures2.15195350
18MP0004885_abnormal_endolymph2.13224462
19MP0001188_hyperpigmentation2.10540618
20MP0001440_abnormal_grooming_behavior2.03290891
21MP0002909_abnormal_adrenal_gland1.98809393
22MP0000343_altered_response_to1.93850484
23MP0003300_gastrointestinal_ulcer1.93367300
24MP0004043_abnormal_pH_regulation1.92943661
25MP0001529_abnormal_vocalization1.90526922
26MP0009046_muscle_twitch1.89794832
27MP0003566_abnormal_cell_adhesion1.89735985
28MP0001501_abnormal_sleep_pattern1.87096920
29MP0002272_abnormal_nervous_system1.85890171
30MP0002796_impaired_skin_barrier1.81417266
31MP0004858_abnormal_nervous_system1.80035396
32MP0002063_abnormal_learning/memory/cond1.79455934
33MP0009840_abnormal_foam_cell1.78265685
34MP0004185_abnormal_adipocyte_glucose1.75622645
35MP0003195_calcinosis1.75588023
36MP0004510_myositis1.75484522
37MP0002734_abnormal_mechanical_nocicepti1.74383284
38MP0003634_abnormal_glial_cell1.73553014
39MP0009745_abnormal_behavioral_response1.70143874
40MP0009780_abnormal_chondrocyte_physiolo1.69600450
41MP0005248_abnormal_Harderian_gland1.68313425
42MP0002733_abnormal_thermal_nociception1.63177801
43MP0000747_muscle_weakness1.62759046
44MP0001984_abnormal_olfaction1.61035222
45MP0010678_abnormal_skin_adnexa1.55158414
46MP0003448_altered_tumor_morphology1.54315129
47MP0005367_renal/urinary_system_phenotyp1.53124223
48MP0000516_abnormal_urinary_system1.53124223
49MP0001486_abnormal_startle_reflex1.52946726
50MP0004272_abnormal_basement_membrane1.51473400
51MP0003724_increased_susceptibility_to1.51409857
52MP0002139_abnormal_hepatobiliary_system1.51053810
53MP0005085_abnormal_gallbladder_physiolo1.49401392
54MP0001542_abnormal_bone_strength1.49226456
55MP0005451_abnormal_body_composition1.47236347
56MP0003806_abnormal_nucleotide_metabolis1.44664776
57MP0003186_abnormal_redox_activity1.44494227
58MP0003075_altered_response_to1.44378095
59MP0003633_abnormal_nervous_system1.41812805
60MP0005501_abnormal_skin_physiology1.41807158
61MP0003656_abnormal_erythrocyte_physiolo1.40880587
62MP0008004_abnormal_stomach_pH1.40052443
63MP0002572_abnormal_emotion/affect_behav1.38343179
64MP0001299_abnormal_eye_distance/1.37462939
65MP0003705_abnormal_hypodermis_morpholog1.37036486
66MP0001915_intracranial_hemorrhage1.36852940
67MP0001970_abnormal_pain_threshold1.36761535
68MP0003091_abnormal_cell_migration1.35071853
69MP0005058_abnormal_lysosome_morphology1.33547045
70MP0001853_heart_inflammation1.30792206
71MP0001727_abnormal_embryo_implantation1.28341147
72MP0005165_increased_susceptibility_to1.27207556
73MP0009384_cardiac_valve_regurgitation1.24942819
74MP0008260_abnormal_autophagy1.23266514
75MP0005623_abnormal_meninges_morphology1.23048156
76MP0004742_abnormal_vestibular_system1.22876019
77MP0005257_abnormal_intraocular_pressure1.21549766
78MP0004924_abnormal_behavior1.20692366
79MP0005386_behavior/neurological_phenoty1.20692366
80MP0000778_abnormal_nervous_system1.19384469
81MP0003631_nervous_system_phenotype1.18991590
82MP0009764_decreased_sensitivity_to1.17875175
83MP0005535_abnormal_body_temperature1.15660185
84MP0006082_CNS_inflammation1.15119822
85MP0005360_urolithiasis1.15070827
86MP0000955_abnormal_spinal_cord1.14190358
87MP0005166_decreased_susceptibility_to1.12954899
88MP0003632_abnormal_nervous_system1.10614867
89MP0002067_abnormal_sensory_capabilities1.10338954
90MP0002066_abnormal_motor_capabilities/c1.09612562
91MP0001666_abnormal_nutrient_absorption1.09237902
92MP0005332_abnormal_amino_acid1.08116451
93MP0002254_reproductive_system_inflammat1.08052861
94MP0002118_abnormal_lipid_homeostasis1.07017585
95MP0002837_dystrophic_cardiac_calcinosis1.06865108
96MP0001485_abnormal_pinna_reflex1.06505913
97MP0004130_abnormal_muscle_cell1.06477144
98MP0000358_abnormal_cell_content/1.06471380
99MP0004233_abnormal_muscle_weight1.05410536
100MP0004145_abnormal_muscle_electrophysio1.04332205
101MP0005275_abnormal_skin_tensile1.03510348
102MP0001968_abnormal_touch/_nociception1.03466681
103MP0005083_abnormal_biliary_tract1.01920018
104MP0005365_abnormal_bile_salt1.01752059
105MP0004142_abnormal_muscle_tone1.01317623
106MP0001191_abnormal_skin_condition1.00209728
107MP0008877_abnormal_DNA_methylation0.97912084
108MP0003828_pulmonary_edema0.97861601
109MP0002822_catalepsy0.97742297
110MP0000462_abnormal_digestive_system0.95781696
111MP0002060_abnormal_skin_morphology0.95442267
112MP0002090_abnormal_vision0.95315782
113MP0003453_abnormal_keratinocyte_physiol0.94842945
114MP0005167_abnormal_blood-brain_barrier0.94575850
115MP0008569_lethality_at_weaning0.94184589
116MP0003191_abnormal_cellular_cholesterol0.93463468
117MP0001661_extended_life_span0.92408490
118MP0001216_abnormal_epidermal_layer0.92002575
119MP0008932_abnormal_embryonic_tissue0.91106150
120MP0002009_preneoplasia0.90825122
121MP0002184_abnormal_innervation0.90730732
122MP0003890_abnormal_embryonic-extraembry0.90630694
123MP0006276_abnormal_autonomic_nervous0.90584584
124MP0005384_cellular_phenotype0.90399962
125MP0002229_neurodegeneration0.88733211
126MP0002877_abnormal_melanocyte_morpholog0.88500481
127MP0008007_abnormal_cellular_replicative0.88329591
128MP0005621_abnormal_cell_physiology0.87666856
129MP0005187_abnormal_penis_morphology0.86739808
130MP0002896_abnormal_bone_mineralization0.86183777
131MP0003950_abnormal_plasma_membrane0.85804369
132MP0000003_abnormal_adipose_tissue0.84322695
133MP0005379_endocrine/exocrine_gland_phen0.83535981
134MP0001177_atelectasis0.83358391
135MP0006035_abnormal_mitochondrial_morpho0.82701310
136MP0004957_abnormal_blastocyst_morpholog0.82624988
137MP0008875_abnormal_xenobiotic_pharmacok0.82547567
138MP0009703_decreased_birth_body0.82237143
139MP0002735_abnormal_chemical_nociception0.82000233
140MP0002972_abnormal_cardiac_muscle0.80689786
141MP0002882_abnormal_neuron_morphology0.80478648
142MP0004811_abnormal_neuron_physiology0.79929962
143MP0001905_abnormal_dopamine_level0.79649437
144MP0000579_abnormal_nail_morphology0.79023223
145MP0002133_abnormal_respiratory_system0.78862715
146MP0005388_respiratory_system_phenotype0.78862715
147MP0000537_abnormal_urethra_morphology0.78849014
148MP0001348_abnormal_lacrimal_gland0.77289579
149MP0004215_abnormal_myocardial_fiber0.77281720
150MP0004484_altered_response_of0.76958595
151MP0000647_abnormal_sebaceous_gland0.75676261
152MP0008438_abnormal_cutaneous_collagen0.73729562
153MP0005164_abnormal_response_to0.73619952
154MP0000465_gastrointestinal_hemorrhage0.71568394
155MP0005375_adipose_tissue_phenotype0.70449950
156MP0009672_abnormal_birth_weight0.69765783
157MP0005595_abnormal_vascular_smooth0.68999472
158MP0010368_abnormal_lymphatic_system0.68510147
159MP0008873_increased_physiological_sensi0.66498503
160MP0004036_abnormal_muscle_relaxation0.66344071
161MP0010386_abnormal_urinary_bladder0.66065008
162MP0002295_abnormal_pulmonary_circulatio0.65091156
163MP0001346_abnormal_lacrimal_gland0.64221206
164MP0001502_abnormal_circadian_rhythm0.63842736

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.01602142
2Cerebral inclusion bodies (HP:0100314)4.48480742
3Papillary thyroid carcinoma (HP:0002895)4.42237787
4Tetraparesis (HP:0002273)4.02555361
5Agnosia (HP:0010524)4.01328078
6Disinhibition (HP:0000734)3.76021155
7Cortical dysplasia (HP:0002539)3.64985996
8Insidious onset (HP:0003587)3.55932696
9Termporal pattern (HP:0011008)3.55932696
10Supranuclear gaze palsy (HP:0000605)3.38866516
11Spastic diplegia (HP:0001264)3.35813970
12Upper limb muscle weakness (HP:0003484)3.31806631
13Abnormality of the musculature of the pelvis (HP:0001469)3.26993057
14Abnormality of the hip-girdle musculature (HP:0001445)3.26993057
15Myokymia (HP:0002411)3.17194228
16Intention tremor (HP:0002080)3.06958322
17Shoulder girdle muscle weakness (HP:0003547)3.06890461
18Thyroid carcinoma (HP:0002890)3.06876606
19Action tremor (HP:0002345)3.02114833
20Ankle clonus (HP:0011448)3.00999602
21Focal motor seizures (HP:0011153)2.94823074
22Hyperglycinemia (HP:0002154)2.90733074
23Polyphagia (HP:0002591)2.77307845
24Pelvic girdle muscle weakness (HP:0003749)2.77262268
25Atrophy/Degeneration involving motor neurons (HP:0007373)2.76111982
26Peripheral hypomyelination (HP:0007182)2.72681150
27Nuclear cataract (HP:0100018)2.72343597
28Visual hallucinations (HP:0002367)2.71087194
29Gout (HP:0001997)2.70479703
30Curly hair (HP:0002212)2.68324493
31Abnormal hair whorl (HP:0010721)2.67932751
32Dysmetria (HP:0001310)2.67832542
33Apathy (HP:0000741)2.67179893
34Inappropriate behavior (HP:0000719)2.65255650
35Amyotrophic lateral sclerosis (HP:0007354)2.64157501
36Atonic seizures (HP:0010819)2.63813114
37Achilles tendon contracture (HP:0001771)2.60155121
38Autoamputation (HP:0001218)2.56920346
39Abnormality of the Achilles tendon (HP:0005109)2.56786571
40Stenosis of the external auditory canal (HP:0000402)2.52396407
41Segmental peripheral demyelination/remyelination (HP:0003481)2.51889498
42Abnormality of the anterior horn cell (HP:0006802)2.51213311
43Degeneration of anterior horn cells (HP:0002398)2.51213311
44Abnormality of the corticospinal tract (HP:0002492)2.47500569
45Muscle fiber splitting (HP:0003555)2.47317657
46Diminished motivation (HP:0000745)2.46968311
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43870999
48Global brain atrophy (HP:0002283)2.42432646
49Focal seizures (HP:0007359)2.42395666
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.42235178
51Cerebral hemorrhage (HP:0001342)2.42194702
52Megalencephaly (HP:0001355)2.41984661
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41702526
54Degeneration of the lateral corticospinal tracts (HP:0002314)2.41702526
55Xanthomatosis (HP:0000991)2.38528645
56Delusions (HP:0000746)2.35872821
57Medulloblastoma (HP:0002885)2.33071158
58Abnormal gallbladder physiology (HP:0012438)2.33020724
59Cholecystitis (HP:0001082)2.33020724
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.32174844
61Abnormality of glycolipid metabolism (HP:0010969)2.32174844
62Abnormality of liposaccharide metabolism (HP:0010968)2.32174844
63Restlessness (HP:0000711)2.30869787
64Abnormality of glycine metabolism (HP:0010895)2.30854732
65Abnormality of serine family amino acid metabolism (HP:0010894)2.30854732
66Dialeptic seizures (HP:0011146)2.30759998
67Aplasia involving bones of the upper limbs (HP:0009823)2.29907215
68Aplasia of the phalanges of the hand (HP:0009802)2.29907215
69Aplasia involving bones of the extremities (HP:0009825)2.29907215
70Tetraplegia (HP:0002445)2.29687367
71Spastic gait (HP:0002064)2.28963209
72Onion bulb formation (HP:0003383)2.28695524
73Spastic tetraparesis (HP:0001285)2.27476493
74Split foot (HP:0001839)2.26941772
75Absence seizures (HP:0002121)2.22047617
76Clonus (HP:0002169)2.20860516
77Pheochromocytoma (HP:0002666)2.20688254
78Progressive inability to walk (HP:0002505)2.17250189
79Hyperglycinuria (HP:0003108)2.12676001
80Abnormal auditory evoked potentials (HP:0006958)2.12062942
81Vacuolated lymphocytes (HP:0001922)2.10793568
82Transitional cell carcinoma of the bladder (HP:0006740)2.10677660
83Loss of speech (HP:0002371)2.10386670
84Turricephaly (HP:0000262)2.09891224
85Urinary urgency (HP:0000012)2.08653261
86Dysdiadochokinesis (HP:0002075)2.07825170
87Congenital primary aphakia (HP:0007707)2.06581034
88Gait imbalance (HP:0002141)2.06306004
89Akinesia (HP:0002304)2.04886953
90Clumsiness (HP:0002312)2.03556483
91Generalized tonic-clonic seizures (HP:0002069)2.03036005
92Neoplasm of the thyroid gland (HP:0100031)2.01989930
93Neuroendocrine neoplasm (HP:0100634)2.00684706
94Symptomatic seizures (HP:0011145)2.00281326
95Hematochezia (HP:0002573)2.00219696
96Freckling (HP:0001480)1.99998215
97Increased serum pyruvate (HP:0003542)1.99066218
98Nephrogenic diabetes insipidus (HP:0009806)1.98785061
99Axonal loss (HP:0003447)1.97947531
100Spastic paraparesis (HP:0002313)1.97487859
101Hyperlipoproteinemia (HP:0010980)1.97342819
102Thickened helices (HP:0000391)1.94214184
103CNS hypomyelination (HP:0003429)1.93282039
104Abnormality of the motor neurons (HP:0002450)1.92889281
105Abnormal neuron morphology (HP:0012757)1.92889281
106Erythroderma (HP:0001019)1.92787415
107Bladder carcinoma (HP:0002862)1.92602102
108Bladder neoplasm (HP:0009725)1.92602102
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92381515
110Delayed gross motor development (HP:0002194)1.91644255
111Intrahepatic cholestasis (HP:0001406)1.90422490
112Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.89822290
113Palpitations (HP:0001962)1.88151657
114Cerebral hypomyelination (HP:0006808)1.88099730
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85500466
116Thick nail (HP:0001805)1.85498373
117Abnormality of glycolysis (HP:0004366)1.84870506
118Distal sensory impairment (HP:0002936)1.84865886
119Ventricular fibrillation (HP:0001663)1.84554703
120Peripheral demyelination (HP:0011096)1.83532615
121Premature rupture of membranes (HP:0001788)1.82996026
122Hand muscle atrophy (HP:0009130)1.82754918
123Truncal ataxia (HP:0002078)1.82016757
124Dysostosis multiplex (HP:0000943)1.81677687
125Biliary tract neoplasm (HP:0100574)1.81434875
126Decreased motor nerve conduction velocity (HP:0003431)1.80921531
127Irritability (HP:0000737)1.80002371
128Increased cerebral lipofuscin (HP:0011813)1.79990753
129Hyporeflexia of lower limbs (HP:0002600)1.79106217
130Atrioventricular block (HP:0001678)1.79081064
131Neuronal loss in central nervous system (HP:0002529)1.78944716
132Choroideremia (HP:0001139)1.78175668
133Cutaneous melanoma (HP:0012056)1.78129323
134Patchy hypopigmentation of hair (HP:0011365)1.78074940
135Anxiety (HP:0000739)1.77652988
136Parakeratosis (HP:0001036)1.76799138
137Mutism (HP:0002300)1.76785331
138Abnormal eating behavior (HP:0100738)1.76259265
139Impaired vibration sensation in the lower limbs (HP:0002166)1.76254549
140Medial flaring of the eyebrow (HP:0010747)1.76187042
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75471445
142Progressive external ophthalmoplegia (HP:0000590)1.75353112
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75289749
144Synostosis involving the elbow (HP:0003938)1.74817945
145Humeroradial synostosis (HP:0003041)1.74817945
146Amyloidosis (HP:0011034)1.74704104
147Depression (HP:0000716)1.74666847
148Lower limb muscle weakness (HP:0007340)1.74524121
149Rapidly progressive (HP:0003678)1.74368762
150Scanning speech (HP:0002168)1.74214153
151Metaphyseal dysplasia (HP:0100255)1.74166833
152Paraparesis (HP:0002385)1.73715222
153Bronchomalacia (HP:0002780)1.73462900
154Difficulty running (HP:0009046)1.73201241
155Hip dysplasia (HP:0001385)1.72963019
156Exercise-induced muscle cramps (HP:0003710)1.72280069
157Malignant gastrointestinal tract tumors (HP:0006749)1.72029754
158Gastrointestinal carcinoma (HP:0002672)1.72029754
159Uterine neoplasm (HP:0010784)1.71720734
160Hammertoe (HP:0001765)1.70573217
161Neoplasm of the small intestine (HP:0100833)1.70551383
162Gowers sign (HP:0003391)1.70012812
163Resting tremor (HP:0002322)1.67248175
164Neoplasm of the peripheral nervous system (HP:0100007)1.66779941
165Generalized myoclonic seizures (HP:0002123)1.66073153
166Buphthalmos (HP:0000557)1.65465706
167Postural tremor (HP:0002174)1.65150990
168Rigidity (HP:0002063)1.64424900
169Anteriorly placed anus (HP:0001545)1.63911238
170Morphological abnormality of the pyramidal tract (HP:0002062)1.63022633
171Deep venous thrombosis (HP:0002625)1.62293082
172Congenital ichthyosiform erythroderma (HP:0007431)1.62139826
173Hyperglycemia (HP:0003074)1.61992273
174Postnatal microcephaly (HP:0005484)1.61432484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.64125631
2MAP3K93.40793824
3TRIM283.30916815
4NTRK13.07708441
5KSR22.86472141
6ERBB32.66381976
7OXSR12.57806691
8PLK22.31222524
9FGFR22.23226630
10EPHA42.17690117
11MAP3K22.15736175
12NTRK32.12004330
13EIF2AK32.10330524
14PAK62.04143105
15TSSK62.02058855
16RIPK42.01935909
17PNCK1.97450499
18TYRO31.94922915
19WNK41.92900361
20TNIK1.90747444
21SIK31.82620384
22SCYL21.79440156
23GRK71.78571531
24ARAF1.76989793
25BMPR21.75875097
26TESK11.75858308
27STK241.70178543
28DYRK31.65278871
29IRAK31.63362800
30SRPK11.62244006
31FRK1.59801138
32EPHB11.54188300
33MINK11.53139174
34KSR11.53013646
35PAK31.51108841
36STK38L1.49801366
37DDR21.47744630
38EIF2AK11.46707214
39BCR1.45947214
40PLK31.45881172
41MAP2K41.45402399
42STK161.41840735
43MET1.40602424
44DAPK21.39867979
45CSNK1G21.38163059
46LATS21.32811503
47PINK11.31773764
48MAPKAPK51.31457325
49TRIB31.29591877
50LMTK21.28401206
51NEK11.26909657
52LIMK11.26357299
53MARK11.25414257
54MAP2K71.22377935
55PAK41.17078428
56CDK191.16924458
57CDK51.16498628
58CAMKK21.16390733
59YES11.16386651
60STK31.16255346
61UHMK11.12829241
62MYLK1.11998806
63EPHA31.11892675
64GRK51.11610406
65PDPK11.08600808
66CSNK1G31.07851743
67DMPK1.07230714
68FGR1.06821063
69PRKD31.06819808
70PIM21.05574101
71CSNK1G11.04992935
72RET1.03946448
73FER1.02645454
74WNK11.00636505
75MAP3K140.97935175
76CLK10.96558009
77CAMK2B0.96394999
78GSK3A0.95581163
79MAP3K130.93544228
80CAMKK10.92137667
81PHKG20.91647694
82PHKG10.91647694
83MAPK150.91166929
84CSNK1A1L0.90178884
85MAP3K40.90014357
86MST40.89086010
87CAMK2G0.88692087
88STK110.87449834
89AKT30.87347113
90RAF10.85101509
91CAMK2D0.81801872
92CDK140.80594548
93PDK20.78560355
94PDK10.76786954
95MAP3K10.76598874
96PTK20.76522147
97CAMK2A0.76372846
98PDK40.76319060
99PDK30.76319060
100BMPR1B0.76262346
101ALK0.74322730
102ERBB40.73401309
103EGFR0.73233840
104TTK0.73155263
105MKNK10.72683977
106MAP2K10.72407849
107BCKDK0.72397484
108IRAK10.71478998
109ABL20.71442640
110WNK30.66229352
111PDGFRA0.65263895
112* PRKCE0.64743797
113MOS0.62576122
114PRKCG0.62470557
115ICK0.62384308
116NLK0.61690667
117TGFBR20.60304648
118PRKD10.60007817
119NEK60.59897367
120TIE10.59653954
121RPS6KA40.59240249
122MKNK20.57579119
123NTRK20.56587898
124ROCK20.55905100
125MELK0.55221145
126DAPK10.55142026
127BRAF0.54976250
128CDK150.53380664
129LATS10.51558228
130MAP3K30.51162134
131TAF10.50786223
132PIK3CA0.50264643
133PRKCH0.49580924
134EIF2AK20.48140109
135STK380.47771704
136CDK60.47651146
137MAP3K120.46255110
138MAPK100.45357386
139NEK90.45325987
140JAK10.44681513
141CDK180.44555385
142SGK2230.44257115
143SGK4940.44257115
144MAP2K20.44023410
145PBK0.43334699
146MAP3K50.43306092
147ACVR1B0.42373013
148PDGFRB0.41973218
149PKN10.41549210
150DYRK20.41487115
151CDK11A0.40080574
152HIPK20.39673208
153FGFR10.37665505
154DYRK1A0.37430529

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.79854176
2Protein export_Homo sapiens_hsa030603.45792251
3Vitamin B6 metabolism_Homo sapiens_hsa007502.80524517
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.46522544
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.38670167
6Legionellosis_Homo sapiens_hsa051342.17209726
7Salmonella infection_Homo sapiens_hsa051322.13801985
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07692069
9Shigellosis_Homo sapiens_hsa051312.06076718
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93613312
11Proteasome_Homo sapiens_hsa030501.84396866
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.81866682
13Synaptic vesicle cycle_Homo sapiens_hsa047211.78016812
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65552480
15GABAergic synapse_Homo sapiens_hsa047271.63215074
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60189453
17Steroid biosynthesis_Homo sapiens_hsa001001.57987125
18Sulfur metabolism_Homo sapiens_hsa009201.57810727
19Adherens junction_Homo sapiens_hsa045201.57779459
20Fatty acid elongation_Homo sapiens_hsa000621.52643494
21Butanoate metabolism_Homo sapiens_hsa006501.48976090
22Long-term potentiation_Homo sapiens_hsa047201.48474037
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40657237
24Collecting duct acid secretion_Homo sapiens_hsa049661.39769924
25Arginine biosynthesis_Homo sapiens_hsa002201.39684564
26Amphetamine addiction_Homo sapiens_hsa050311.37270072
27Dorso-ventral axis formation_Homo sapiens_hsa043201.32443229
28Dopaminergic synapse_Homo sapiens_hsa047281.29149439
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28119491
30Gastric acid secretion_Homo sapiens_hsa049711.27165018
31Salivary secretion_Homo sapiens_hsa049701.26224484
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.26222392
33* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25680374
34Regulation of autophagy_Homo sapiens_hsa041401.24750620
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22946702
36Fatty acid biosynthesis_Homo sapiens_hsa000611.22473654
37Glutamatergic synapse_Homo sapiens_hsa047241.21320483
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.17971891
39Long-term depression_Homo sapiens_hsa047301.17228145
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16216588
41Pertussis_Homo sapiens_hsa051331.14147858
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12235424
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11742971
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11721565
45Cocaine addiction_Homo sapiens_hsa050301.11254642
46Vibrio cholerae infection_Homo sapiens_hsa051101.11188465
47Ether lipid metabolism_Homo sapiens_hsa005651.08986669
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08903578
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07481140
50Renin secretion_Homo sapiens_hsa049241.06746528
51Olfactory transduction_Homo sapiens_hsa047401.05910112
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04654509
53Insulin secretion_Homo sapiens_hsa049111.04198774
54Nicotine addiction_Homo sapiens_hsa050331.03959548
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03952638
56Prion diseases_Homo sapiens_hsa050201.03175930
57Renal cell carcinoma_Homo sapiens_hsa052111.02401617
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.00342761
59African trypanosomiasis_Homo sapiens_hsa051430.99943952
60* Phagosome_Homo sapiens_hsa041450.99906535
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99040892
62Pancreatic secretion_Homo sapiens_hsa049720.98539600
63Circadian entrainment_Homo sapiens_hsa047130.97777042
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97677010
65Bile secretion_Homo sapiens_hsa049760.95095054
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94242540
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89763439
68Tight junction_Homo sapiens_hsa045300.88994645
69Estrogen signaling pathway_Homo sapiens_hsa049150.88978767
70Lysosome_Homo sapiens_hsa041420.88639238
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86717986
72Gap junction_Homo sapiens_hsa045400.86600716
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86553004
74Morphine addiction_Homo sapiens_hsa050320.85561396
75Folate biosynthesis_Homo sapiens_hsa007900.84851454
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84070899
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.83513707
78Serotonergic synapse_Homo sapiens_hsa047260.83065610
79GnRH signaling pathway_Homo sapiens_hsa049120.81234767
80Fatty acid metabolism_Homo sapiens_hsa012120.80051628
81Carbon metabolism_Homo sapiens_hsa012000.78720655
82Cholinergic synapse_Homo sapiens_hsa047250.78208372
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.77731948
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77607463
85Thyroid cancer_Homo sapiens_hsa052160.77510190
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77304334
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76580130
88Malaria_Homo sapiens_hsa051440.75190901
89Circadian rhythm_Homo sapiens_hsa047100.73930423
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.73553198
91TNF signaling pathway_Homo sapiens_hsa046680.72472662
92* Amoebiasis_Homo sapiens_hsa051460.72051769
93Endometrial cancer_Homo sapiens_hsa052130.71856671
94Oxytocin signaling pathway_Homo sapiens_hsa049210.71819329
95Histidine metabolism_Homo sapiens_hsa003400.71408124
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70915649
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69808624
98Sphingolipid metabolism_Homo sapiens_hsa006000.69092139
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68995716
100mTOR signaling pathway_Homo sapiens_hsa041500.67735175
101Arginine and proline metabolism_Homo sapiens_hsa003300.66730453
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66646418
103Basal transcription factors_Homo sapiens_hsa030220.66187428
104* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65586155
105Biosynthesis of amino acids_Homo sapiens_hsa012300.65046822
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64768961
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.64050611
108* Tuberculosis_Homo sapiens_hsa051520.64009683
109ErbB signaling pathway_Homo sapiens_hsa040120.63021884
110Hepatitis C_Homo sapiens_hsa051600.61710823
111Taste transduction_Homo sapiens_hsa047420.61384431
112Thyroid hormone synthesis_Homo sapiens_hsa049180.60794887
113Proteoglycans in cancer_Homo sapiens_hsa052050.60673298
114* Endocytosis_Homo sapiens_hsa041440.59704240
115Galactose metabolism_Homo sapiens_hsa000520.59113988
116Type II diabetes mellitus_Homo sapiens_hsa049300.58069676
117Mineral absorption_Homo sapiens_hsa049780.57956415
118PPAR signaling pathway_Homo sapiens_hsa033200.57932317
119Glioma_Homo sapiens_hsa052140.57727905
120Fat digestion and absorption_Homo sapiens_hsa049750.57098278
121Choline metabolism in cancer_Homo sapiens_hsa052310.56690690
122Axon guidance_Homo sapiens_hsa043600.56575687
123TGF-beta signaling pathway_Homo sapiens_hsa043500.55882055
124Melanogenesis_Homo sapiens_hsa049160.54394616
125Propanoate metabolism_Homo sapiens_hsa006400.54328850
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.54161732
127cAMP signaling pathway_Homo sapiens_hsa040240.53907284
128VEGF signaling pathway_Homo sapiens_hsa043700.53077387
129Hepatitis B_Homo sapiens_hsa051610.52856383
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52725848
131beta-Alanine metabolism_Homo sapiens_hsa004100.52583360
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51652660
133Oocyte meiosis_Homo sapiens_hsa041140.50304877
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48892751
135Glutathione metabolism_Homo sapiens_hsa004800.48025218
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46609955
137mRNA surveillance pathway_Homo sapiens_hsa030150.46513580
138AMPK signaling pathway_Homo sapiens_hsa041520.46372889
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45986414
140Chemokine signaling pathway_Homo sapiens_hsa040620.45895894
141HIF-1 signaling pathway_Homo sapiens_hsa040660.45542001
142Linoleic acid metabolism_Homo sapiens_hsa005910.45260669
143Colorectal cancer_Homo sapiens_hsa052100.45085226
144Calcium signaling pathway_Homo sapiens_hsa040200.42641563
145Osteoclast differentiation_Homo sapiens_hsa043800.42173404
146Pyruvate metabolism_Homo sapiens_hsa006200.41670291
147Rheumatoid arthritis_Homo sapiens_hsa053230.41526225
148Rap1 signaling pathway_Homo sapiens_hsa040150.41042093
149Hippo signaling pathway_Homo sapiens_hsa043900.40264673
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39792510
1512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38675497
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37507075
153p53 signaling pathway_Homo sapiens_hsa041150.36214864
154* Ras signaling pathway_Homo sapiens_hsa040140.36157804
155Pancreatic cancer_Homo sapiens_hsa052120.34943177
156Prostate cancer_Homo sapiens_hsa052150.34612000
157Influenza A_Homo sapiens_hsa051640.32656266
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.30674575

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