ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	alpha-linolenic acid metabolic process (GO:0036109)	4.16365193
2	lysine catabolic process (GO:0006554)	3.64766010
3	lysine metabolic process (GO:0006553)	3.64766010
4	L-phenylalanine catabolic process (GO:0006559)	3.30101495
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.30101495
6	dicarboxylic acid biosynthetic process (GO:0043650)	3.26332596
7	regulation of fatty acid beta-oxidation (GO:0031998)	3.19989171
8	2-oxoglutarate metabolic process (GO:0006103)	3.19295104
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.19095247
10	L-phenylalanine metabolic process (GO:0006558)	3.19095247
11	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.18211850
12	regulation of cholesterol homeostasis (GO:2000188)	3.15795365
13	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.13561835
14	sulfur amino acid catabolic process (GO:0000098)	3.09784150
15	synaptic vesicle maturation (GO:0016188)	3.04939438
16	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.03464109
17	cellular potassium ion homeostasis (GO:0030007)	3.01872629
18	fatty acid transmembrane transport (GO:1902001)	2.94062669
19	cerebellar granule cell differentiation (GO:0021707)	2.91536116
20	low-density lipoprotein particle clearance (GO:0034383)	2.84223415
21	kynurenine metabolic process (GO:0070189)	2.81341887
22	tricarboxylic acid metabolic process (GO:0072350)	2.80321685
23	complement activation, alternative pathway (GO:0006957)	2.79982051
24	negative regulation of fibrinolysis (GO:0051918)	2.79158172
25	positive regulation of lipid catabolic process (GO:0050996)	2.78238500
26	carnitine shuttle (GO:0006853)	2.76524513
27	macroautophagy (GO:0016236)	2.75363221
28	cellular modified amino acid catabolic process (GO:0042219)	2.75060540
29	protein localization to endosome (GO:0036010)	2.75010798
30	positive regulation of fatty acid oxidation (GO:0046321)	2.74611918
31	cysteine metabolic process (GO:0006534)	2.73881480
32	glutamate metabolic process (GO:0006536)	2.72993992
33	sodium ion export (GO:0071436)	2.72669151
34	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.72053179
35	activation of protein kinase A activity (GO:0034199)	2.71779828
36	urea cycle (GO:0000050)	2.71757127
37	urea metabolic process (GO:0019627)	2.71757127
38	aspartate family amino acid catabolic process (GO:0009068)	2.69974681
39	aromatic amino acid family catabolic process (GO:0009074)	2.69866805
40	valine metabolic process (GO:0006573)	2.69844180
41	alanine transport (GO:0032328)	2.69652240
42	regulation of early endosome to late endosome transport (GO:2000641)	2.68972735
43	locomotory exploration behavior (GO:0035641)	2.68156309
44	regulation of fatty acid oxidation (GO:0046320)	2.67814498
45	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.66948371
46	bile acid biosynthetic process (GO:0006699)	2.65816045
47	regulation of synaptic vesicle exocytosis (GO:2000300)	2.65728949
48	glyoxylate metabolic process (GO:0046487)	2.61481860
49	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.61029188
50	peptidyl-glutamic acid carboxylation (GO:0017187)	2.60873977
51	protein carboxylation (GO:0018214)	2.60873977
52	Golgi transport vesicle coating (GO:0048200)	2.58993785
53	COPI coating of Golgi vesicle (GO:0048205)	2.58993785
54	plasma lipoprotein particle clearance (GO:0034381)	2.58841552
55	cellular ketone body metabolic process (GO:0046950)	2.58544203
56	desmosome organization (GO:0002934)	2.58490550
57	oxaloacetate metabolic process (GO:0006107)	2.57536922
58	plasma membrane repair (GO:0001778)	2.57132510
59	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.55845246
60	regulation of protein activation cascade (GO:2000257)	2.54021475
61	high-density lipoprotein particle remodeling (GO:0034375)	2.52335926
62	phospholipid homeostasis (GO:0055091)	2.52092543
63	adherens junction assembly (GO:0034333)	2.49536923
64	regulation of cholesterol storage (GO:0010885)	2.49396770
65	negative regulation of cell size (GO:0045792)	2.48729615
66	cell-substrate adherens junction assembly (GO:0007045)	2.47246131
67	focal adhesion assembly (GO:0048041)	2.47246131
68	amino-acid betaine metabolic process (GO:0006577)	2.45666189
69	regulation of complement activation (GO:0030449)	2.45236394
70	fatty acid homeostasis (GO:0055089)	2.45187830
71	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.44361151
72	protein targeting to plasma membrane (GO:0072661)	2.44133223
73	dicarboxylic acid catabolic process (GO:0043649)	2.43118177
74	positive regulation of glycogen biosynthetic process (GO:0045725)	2.42831121
75	cell communication by electrical coupling (GO:0010644)	2.41965562
76	reverse cholesterol transport (GO:0043691)	2.41475072
77	negative regulation of erythrocyte differentiation (GO:0045647)	2.41467167
78	fatty acid beta-oxidation (GO:0006635)	2.41359652
79	regulation of triglyceride catabolic process (GO:0010896)	2.41241448
80	cellular response to catecholamine stimulus (GO:0071870)	2.41142267
81	cellular response to monoamine stimulus (GO:0071868)	2.41142267
82	synaptic vesicle exocytosis (GO:0016079)	2.40412508
83	positive regulation of receptor recycling (GO:0001921)	2.39855210
84	nitrogen cycle metabolic process (GO:0071941)	2.39730684
85	negative regulation of sterol transport (GO:0032372)	2.39176408
86	negative regulation of cholesterol transport (GO:0032375)	2.39176408
87	L-amino acid import (GO:0043092)	2.36385382
88	homocysteine metabolic process (GO:0050667)	2.36180206
89	acetyl-CoA metabolic process (GO:0006084)	2.35707355
90	neutral lipid catabolic process (GO:0046461)	2.34996725
91	acylglycerol catabolic process (GO:0046464)	2.34996725
92	positive regulation of fatty acid metabolic process (GO:0045923)	2.33989918
93	barbed-end actin filament capping (GO:0051016)	2.33382676
94	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.33230464
95	regulation of lipid catabolic process (GO:0050994)	2.31961692
96	regulation of synapse structural plasticity (GO:0051823)	2.31157840
97	cell communication involved in cardiac conduction (GO:0086065)	2.31134456
98	regulation of ARF protein signal transduction (GO:0032012)	2.30628070
99	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.30335921
100	fatty acid oxidation (GO:0019395)	2.30189939
101	signal complex assembly (GO:0007172)	2.29618274
102	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.29288646
103	ketone body metabolic process (GO:1902224)	2.28994759
104	bile acid metabolic process (GO:0008206)	2.28838291
105	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.28680436
106	negative regulation of lipid transport (GO:0032369)	2.28354317
107	lipid oxidation (GO:0034440)	2.27702422
108	proline transport (GO:0015824)	2.27432766
109	stress fiber assembly (GO:0043149)	2.27283356
110	positive regulation of triglyceride metabolic process (GO:0090208)	2.27034669
111	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.26843478
112	cell-substrate junction assembly (GO:0007044)	2.26813556
113	amino acid import (GO:0043090)	2.25928065
114	glutamate secretion (GO:0014047)	2.24361784
115	ethanol oxidation (GO:0006069)	2.23425050
116	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.22839404
117	regulation of synaptic vesicle transport (GO:1902803)	2.22732503
118	regulation of fibrinolysis (GO:0051917)	2.22580742
119	growth hormone receptor signaling pathway (GO:0060396)	2.22305455
120	apoptotic cell clearance (GO:0043277)	2.21365132
121	short-chain fatty acid metabolic process (GO:0046459)	2.21220598
122	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.21202904
123	indolalkylamine catabolic process (GO:0046218)	2.21173058
124	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.16809192
125	positive regulation of Rap GTPase activity (GO:0032854)	2.13448627
126	cellular sodium ion homeostasis (GO:0006883)	2.13249652
127	surfactant homeostasis (GO:0043129)	2.11798366
128	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.08971161
129	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.07683335
130	cellular response to epinephrine stimulus (GO:0071872)	2.07593823
131	regulation of clathrin-mediated endocytosis (GO:2000369)	2.06638864
132	regulation of extracellular matrix disassembly (GO:0010715)	2.03783788
133	response to monoamine (GO:0071867)	2.03782032
134	response to catecholamine (GO:0071869)	2.03782032
135	myelin maintenance (GO:0043217)	2.03671963
136	potassium ion homeostasis (GO:0055075)	2.03204192
137	mating behavior (GO:0007617)	2.01346999
138	hypotonic response (GO:0006971)	2.00896951
139	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.00006239
140	negative regulation of fatty acid transport (GO:2000192)	1.99415705
141	positive regulation of cellular amide metabolic process (GO:0034250)	1.99252674
142	insulin-like growth factor receptor signaling pathway (GO:0048009)	1.99028050
143	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.98157859
144	neuromuscular process controlling balance (GO:0050885)	1.98029526
145	epithelial cell differentiation involved in prostate gland development (GO:0060742)	1.97836993
146	layer formation in cerebral cortex (GO:0021819)	1.97800528
147	cell-cell junction maintenance (GO:0045217)	1.97626735
148	regulation of water loss via skin (GO:0033561)	1.96864332
149	protein retention in ER lumen (GO:0006621)	1.96530808
150	semaphorin-plexin signaling pathway (GO:0071526)	1.95598634
151	actin filament depolymerization (GO:0030042)	1.93662006
152	regulation of ARF GTPase activity (GO:0032312)	1.93310288
153	regulation of amyloid precursor protein catabolic process (GO:1902991)	1.92982862
154	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.92518207
155	positive regulation of synapse maturation (GO:0090129)	1.92308287
156	establishment of protein localization to plasma membrane (GO:0090002)	1.91750169
157	skin morphogenesis (GO:0043589)	1.91574088
158	potassium ion import (GO:0010107)	1.91023569
159	negative regulation of catenin import into nucleus (GO:0035414)	1.89611186
160	regulation of glucose import in response to insulin stimulus (GO:2001273)	1.89235015
161	response to parathyroid hormone (GO:0071107)	1.88902960
162	import into cell (GO:0098657)	1.88519684
163	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	1.88402642
164	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	1.88294763
165	dopamine receptor signaling pathway (GO:0007212)	1.87354687
166	response to laminar fluid shear stress (GO:0034616)	1.86705372
167	apical protein localization (GO:0045176)	1.86163049
168	regulation of neuronal synaptic plasticity (GO:0048168)	1.85833479
169	cortical actin cytoskeleton organization (GO:0030866)	1.85035736
170	regulation of T-helper 2 cell differentiation (GO:0045628)	1.84919993
171	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	1.84845458
172	mannose metabolic process (GO:0006013)	1.84017240
173	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	1.83866223
174	basement membrane organization (GO:0071711)	1.82824521
175	maternal placenta development (GO:0001893)	1.82401090
176	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.82353090
177	epithelial cell-cell adhesion (GO:0090136)	1.82194148
178	multicellular organismal water homeostasis (GO:0050891)	1.80981680
179	regulation of Rap GTPase activity (GO:0032317)	1.80724569
180	regulation of beta-amyloid formation (GO:1902003)	1.78950294
181	antigen processing and presentation of endogenous antigen (GO:0019883)	1.78472482
182	negative regulation of cell killing (GO:0031342)	1.78302760
183	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	1.78302760

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.81125436
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.73205766
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.58102241
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.15003576
5	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.03482741
6	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.64579423
7	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.38102637
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.38006041
9	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.32542205
10	CLOCK_20551151_ChIP-Seq_293T_Human	2.05859246
11	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.05603534
12	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.89547276
13	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.84552562
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.80188837
15	LXR_22292898_ChIP-Seq_THP-1_Human	1.71744788
16	* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.68459001
17	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.67405081
18	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.63574909
19	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.62209102
20	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.57680653
21	KDM2B_26808549_Chip-Seq_K562_Human	1.55970243
22	ZNF263_19887448_ChIP-Seq_K562_Human	1.54587582
23	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.50477998
24	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.47902330
25	* ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.47511849
26	DROSHA_22980978_ChIP-Seq_HELA_Human	1.46506067
27	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.42360862
28	KDM2B_26808549_Chip-Seq_DND41_Human	1.40946206
29	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.40774936
30	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.37219167
31	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.36743053
32	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.36362959
33	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.35438415
34	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.34152919
35	EZH2_22144423_ChIP-Seq_EOC_Human	1.32057334
36	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.30873480
37	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.30583318
38	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.29125816
39	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.26623985
40	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.23770688
41	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.21272556
42	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21271425
43	* SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.20475823
44	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.19776543
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.19384516
46	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.18462191
47	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.18030376
48	GATA1_22025678_ChIP-Seq_K562_Human	1.17178848
49	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17150276
50	RACK7_27058665_Chip-Seq_MCF-7_Human	1.16807323
51	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.15179208
52	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.15179208
53	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.14787477
54	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14445325
55	GATA1_19941826_ChIP-Seq_K562_Human	1.12893819
56	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.12424163
57	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.12082839
58	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.11732521
59	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.10973533
60	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.09386250
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08389314
62	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.08304127
63	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.07534796
64	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.07222918
65	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.07205228
66	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06646549
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05561625
68	CREB1_26743006_Chip-Seq_LNCaP_Human	1.05394671
69	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	1.05299588
70	TCF7_22412390_ChIP-Seq_EML_Mouse	1.04994910
71	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.04156421
72	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.03378053
73	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.03256064
74	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02894404
75	* WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.02634206
76	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.00958347
77	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.00790419
78	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.00150772
79	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.99799016
80	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.99732560
81	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99687084
82	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99687084
83	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99060946
84	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.98820955
85	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.98619485
86	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.98460811
87	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.98204580
88	* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.97813096
89	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.97770312
90	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.96962102
91	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.96820734
92	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.96052365
93	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.95907035
94	CTCF_27219007_Chip-Seq_Bcells_Human	0.95438046
95	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.95176810
96	SMC4_20622854_ChIP-Seq_HELA_Human	0.94272976
97	VDR_21846776_ChIP-Seq_THP-1_Human	0.92931787
98	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.92863303
99	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.92252747
100	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.92238575
101	* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.91840943
102	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.91727314
103	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.91030769
104	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.90850267
105	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.90551679
106	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.90454492
107	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.89622443
108	GATA2_19941826_ChIP-Seq_K562_Human	0.89618109
109	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.89134535
110	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.89028460
111	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.87623298
112	* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.87600236
113	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.87385951
114	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.86714629
115	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.85588639
116	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.85294153
117	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.85164577
118	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.85120378
119	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.84678510
120	RXR_22108803_ChIP-Seq_LS180_Human	0.83929881
121	SPI1_23127762_ChIP-Seq_K562_Human	0.83836391
122	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.83455578
123	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.82693097
124	* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.82239854
125	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.80730048
126	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.79916019
127	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.79720122
128	* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.78812515
129	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.78063104

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.13977916
2	MP0005360_urolithiasis	3.73785128
3	MP0005365_abnormal_bile_salt	3.37151803
4	MP0005085_abnormal_gallbladder_physiolo	3.09383555
5	MP0005409_darkened_coat_color	3.06200709
6	MP0003705_abnormal_hypodermis_morpholog	2.87405236
7	MP0004130_abnormal_muscle_cell	2.76452952
8	MP0004859_abnormal_synaptic_plasticity	2.70528075
9	MP0010329_abnormal_lipoprotein_level	2.54336056
10	MP0009840_abnormal_foam_cell	2.54304952
11	MP0002837_dystrophic_cardiac_calcinosis	2.38920563
12	MP0003252_abnormal_bile_duct	2.38325529
13	MP0008875_abnormal_xenobiotic_pharmacok	2.29559268
14	MP0005083_abnormal_biliary_tract	2.24612853
15	MP0002909_abnormal_adrenal_gland	2.23239091
16	MP0009780_abnormal_chondrocyte_physiolo	2.08725241
17	MP0004858_abnormal_nervous_system	2.00852432
18	MP0002796_impaired_skin_barrier	1.97996815
19	MP0003300_gastrointestinal_ulcer	1.95433100
20	MP0003191_abnormal_cellular_cholesterol	1.85418669
21	MP0008961_abnormal_basal_metabolism	1.80354127
22	MP0003329_amyloid_beta_deposits	1.79390809
23	MP0005058_abnormal_lysosome_morphology	1.77999156
24	MP0005451_abnormal_body_composition	1.77040137
25	MP0002118_abnormal_lipid_homeostasis	1.67461975
26	MP0000604_amyloidosis	1.67431369
27	MP0005332_abnormal_amino_acid	1.61739273
28	MP0000013_abnormal_adipose_tissue	1.59875486
29	MP0000751_myopathy	1.58401503
30	MP0003172_abnormal_lysosome_physiology	1.54671123
31	MP0008569_lethality_at_weaning	1.54637072
32	MP0010234_abnormal_vibrissa_follicle	1.54581483
33	MP0003279_aneurysm	1.51067122
34	MP0003195_calcinosis	1.49538055
35	MP0004264_abnormal_extraembryonic_tissu	1.45223451
36	MP0008260_abnormal_autophagy	1.44139141
37	MP0003075_altered_response_to	1.43235029
38	MP0003303_peritoneal_inflammation	1.42285315
39	MP0000609_abnormal_liver_physiology	1.41622616
40	MP0000920_abnormal_myelination	1.39916991
41	MP0001666_abnormal_nutrient_absorption	1.38695109
42	MP0003453_abnormal_keratinocyte_physiol	1.37149643
43	MP0005423_abnormal_somatic_nervous	1.36474851
44	MP0005584_abnormal_enzyme/coenzyme_acti	1.35413603
45	MP0005167_abnormal_blood-brain_barrier	1.34827505
46	MP0005319_abnormal_enzyme/_coenzyme	1.32574516
47	MP0003690_abnormal_glial_cell	1.31738697
48	MP0004270_analgesia	1.29587291
49	MP0003183_abnormal_peptide_metabolism	1.29508404
50	MP0005666_abnormal_adipose_tissue	1.26244273
51	MP0005503_abnormal_tendon_morphology	1.24251263
52	MP0006138_congestive_heart_failure	1.23606937
53	MP0001348_abnormal_lacrimal_gland	1.23256962
54	MP0004381_abnormal_hair_follicle	1.22413568
55	MP0004084_abnormal_cardiac_muscle	1.21756852
56	MP0002877_abnormal_melanocyte_morpholog	1.18016352
57	MP0005670_abnormal_white_adipose	1.17928530
58	MP0008004_abnormal_stomach_pH	1.16511543
59	MP0002269_muscular_atrophy	1.16280527
60	MP0000747_muscle_weakness	1.15830642
61	MP0004087_abnormal_muscle_fiber	1.15521102
62	MP0004947_skin_inflammation	1.15459385
63	MP0002078_abnormal_glucose_homeostasis	1.15248225
64	MP0004185_abnormal_adipocyte_glucose	1.14277621
65	MP0003635_abnormal_synaptic_transmissio	1.13955292
66	MP0002138_abnormal_hepatobiliary_system	1.12217795
67	MP0003634_abnormal_glial_cell	1.11113177
68	MP0005375_adipose_tissue_phenotype	1.10312836
69	MP0005023_abnormal_wound_healing	1.09467310
70	MP0000569_abnormal_digit_pigmentation	1.09433657
71	MP0004036_abnormal_muscle_relaxation	1.08160231
72	MP0003656_abnormal_erythrocyte_physiolo	1.08130759
73	MP0005535_abnormal_body_temperature	1.07048975
74	MP0003828_pulmonary_edema	1.06285020
75	MP0001756_abnormal_urination	1.06209002
76	MP0000003_abnormal_adipose_tissue	1.06138027
77	MP0008438_abnormal_cutaneous_collagen	1.04652357
78	MP0000579_abnormal_nail_morphology	1.03534463
79	MP0003566_abnormal_cell_adhesion	1.02959420
80	MP0003045_fibrosis	1.02263779
81	MP0009643_abnormal_urine_homeostasis	1.01872802
82	MP0003633_abnormal_nervous_system	1.00346474
83	MP0004019_abnormal_vitamin_homeostasis	0.99796874
84	MP0005257_abnormal_intraocular_pressure	0.97362668
85	MP0003806_abnormal_nucleotide_metabolis	0.95274840
86	MP0000566_synostosis	0.94651995
87	MP0002971_abnormal_brown_adipose	0.93880040
88	MP0002998_abnormal_bone_remodeling	0.93693603
89	MP0004043_abnormal_pH_regulation	0.93209820
90	MP0001851_eye_inflammation	0.92342229
91	MP0003283_abnormal_digestive_organ	0.90525079
92	MP0004885_abnormal_endolymph	0.90213219
93	MP0001849_ear_inflammation	0.90111124
94	MP0004233_abnormal_muscle_weight	0.89268434
95	MP0000534_abnormal_ureter_morphology	0.88814307
96	MP0000759_abnormal_skeletal_muscle	0.86863611
97	MP0005334_abnormal_fat_pad	0.86750150
98	MP0002090_abnormal_vision	0.86594084
99	MP0002133_abnormal_respiratory_system	0.86338995
100	MP0005388_respiratory_system_phenotype	0.86338995
101	MP0003436_decreased_susceptibility_to	0.86151621
102	MP0004272_abnormal_basement_membrane	0.84508087
103	MP0003724_increased_susceptibility_to	0.84298314
104	MP0005166_decreased_susceptibility_to	0.84230121
105	MP0002822_catalepsy	0.83986350
106	MP0002089_abnormal_postnatal_growth/wei	0.83939774
107	MP0004510_myositis	0.83238423
108	MP0000678_abnormal_parathyroid_gland	0.83122444
109	MP0001958_emphysema	0.81239354
110	MP0002063_abnormal_learning/memory/cond	0.79887980
111	MP0000767_abnormal_smooth_muscle	0.79753136
112	MP0004484_altered_response_of	0.79401263
113	MP0005076_abnormal_cell_differentiation	0.78262155
114	MP0005464_abnormal_platelet_physiology	0.78247471
115	MP0005248_abnormal_Harderian_gland	0.78244283
116	MP0008874_decreased_physiological_sensi	0.77477224
117	MP0003646_muscle_fatigue	0.77276177
118	MP0001502_abnormal_circadian_rhythm	0.77201586
119	MP0001346_abnormal_lacrimal_gland	0.77007994
120	MP0002734_abnormal_mechanical_nocicepti	0.76697479
121	MP0005501_abnormal_skin_physiology	0.76664152
122	MP0000733_abnormal_muscle_development	0.76301963
123	MP0002972_abnormal_cardiac_muscle	0.76220907
124	MP0005620_abnormal_muscle_contractility	0.75752659
125	MP0005448_abnormal_energy_balance	0.74972183
126	MP0002249_abnormal_larynx_morphology	0.74558403
127	MP0000749_muscle_degeneration	0.74434180
128	MP0005275_abnormal_skin_tensile	0.73621028
129	MP0001533_abnormal_skeleton_physiology	0.73468129
130	MP0003868_abnormal_feces_composition	0.72457293
131	MP0005330_cardiomyopathy	0.71805219
132	MP0002896_abnormal_bone_mineralization	0.71275276
133	MP0004811_abnormal_neuron_physiology	0.70328415
134	MP0000598_abnormal_liver_morphology	0.70280632
135	MP0002168_other_aberrant_phenotype	0.70036171
136	MP0001765_abnormal_ion_homeostasis	0.70029584
137	MP0000377_abnormal_hair_follicle	0.69387406
138	MP0009384_cardiac_valve_regurgitation	0.68507006
139	MP0004782_abnormal_surfactant_physiolog	0.68057099
140	MP0002064_seizures	0.67691862
141	MP0005623_abnormal_meninges_morphology	0.67537477
142	MP0002060_abnormal_skin_morphology	0.67371182
143	MP0010630_abnormal_cardiac_muscle	0.67256824
144	MP0002108_abnormal_muscle_morphology	0.67102243
145	MP0003091_abnormal_cell_migration	0.66433316
146	MP0002098_abnormal_vibrissa_morphology	0.66395521
147	MP0001544_abnormal_cardiovascular_syste	0.66394040
148	MP0005385_cardiovascular_system_phenoty	0.66394040
149	MP0004215_abnormal_myocardial_fiber	0.66198258
150	MP0003879_abnormal_hair_cell	0.65868113

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	3.84884206
2	Obstructive sleep apnea (HP:0002870)	3.48836266
3	Xanthomatosis (HP:0000991)	3.18071138
4	Protrusio acetabuli (HP:0003179)	3.07557868
5	Neurofibrillary tangles (HP:0002185)	3.06961608
6	Complement deficiency (HP:0004431)	2.99808959
7	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.83851128
8	Ketosis (HP:0001946)	2.82599317
9	Arterial tortuosity (HP:0005116)	2.81820435
10	Ketoacidosis (HP:0001993)	2.76159071
11	Vascular tortuosity (HP:0004948)	2.73460255
12	Gout (HP:0001997)	2.65154224
13	Hypoglycemic coma (HP:0001325)	2.59968910
14	Abnormality of the lower motor neuron (HP:0002366)	2.53644161
15	Intrahepatic cholestasis (HP:0001406)	2.52024028
16	Increased variability in muscle fiber diameter (HP:0003557)	2.50669500
17	Distal lower limb muscle weakness (HP:0009053)	2.48100741
18	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.45830989
19	Hyperlipoproteinemia (HP:0010980)	2.39009358
20	Cerebral aneurysm (HP:0004944)	2.35901846
21	Hyperammonemia (HP:0001987)	2.34930860
22	Abnormality of skeletal muscle fiber size (HP:0012084)	2.31725428
23	Exercise-induced myalgia (HP:0003738)	2.31218282
24	Long toe (HP:0010511)	2.28797640
25	Type 1 muscle fiber predominance (HP:0003803)	2.28191174
26	Myoglobinuria (HP:0002913)	2.27845964
27	Hypoalphalipoproteinemia (HP:0003233)	2.25646772
28	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.24418774
29	Epidermoid cyst (HP:0200040)	2.24237100
30	Ankle clonus (HP:0011448)	2.22921707
31	Flat acetabular roof (HP:0003180)	2.22234653
32	Skin nodule (HP:0200036)	2.21624551
33	Lymphangioma (HP:0100764)	2.21349863
34	Asymmetric septal hypertrophy (HP:0001670)	2.21152378
35	Abnormality of the common coagulation pathway (HP:0010990)	2.18645581
36	Mitral stenosis (HP:0001718)	2.18570095
37	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.17023973
38	Upper limb amyotrophy (HP:0009129)	2.16543292
39	Distal upper limb amyotrophy (HP:0007149)	2.16543292
40	Eczematoid dermatitis (HP:0000976)	2.14814881
41	Aortic aneurysm (HP:0004942)	2.13761406
42	Exercise-induced muscle cramps (HP:0003710)	2.13638475
43	Hyporeflexia of lower limbs (HP:0002600)	2.13240601
44	Abnormality of complement system (HP:0005339)	2.11408549
45	Hyperglycinuria (HP:0003108)	2.11264602
46	Urinary glycosaminoglycan excretion (HP:0003541)	2.10790146
47	Mucopolysacchariduria (HP:0008155)	2.10790146
48	Increased cerebral lipofuscin (HP:0011813)	2.08786378
49	Bundle branch block (HP:0011710)	2.08173799
50	Action tremor (HP:0002345)	2.08157912
51	Systemic lupus erythematosus (HP:0002725)	2.07609977
52	Turricephaly (HP:0000262)	2.06931714
53	Abnormality of the Achilles tendon (HP:0005109)	2.06614931
54	Diplopia (HP:0000651)	2.06239757
55	Abnormality of binocular vision (HP:0011514)	2.06239757
56	Premature rupture of membranes (HP:0001788)	2.04968113
57	Hand muscle atrophy (HP:0009130)	2.04835507
58	Enlarged penis (HP:0000040)	2.04800539
59	Myokymia (HP:0002411)	2.04762107
60	Muscle fiber splitting (HP:0003555)	2.03503159
61	Striae distensae (HP:0001065)	2.03213318
62	Increased IgE level (HP:0003212)	2.02216890
63	Hyperparathyroidism (HP:0000843)	2.02094165
64	Supranuclear gaze palsy (HP:0000605)	2.02067330
65	Difficulty running (HP:0009046)	2.01725672
66	Neonatal onset (HP:0003623)	2.01165949
67	Shallow orbits (HP:0000586)	2.01002763
68	Distal lower limb amyotrophy (HP:0008944)	2.00932208
69	Broad metatarsal (HP:0001783)	2.00088972
70	Visual hallucinations (HP:0002367)	1.99684039
71	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.98376060
72	Abnormality of polysaccharide metabolism (HP:0011012)	1.98376060
73	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.98376060
74	Abnormality of purine metabolism (HP:0004352)	1.96534453
75	Mildly elevated creatine phosphokinase (HP:0008180)	1.95891185
76	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.95092000
77	Myocardial infarction (HP:0001658)	1.94820046
78	Aneurysm (HP:0002617)	1.93706934
79	Abnormality of fatty-acid metabolism (HP:0004359)	1.93489635
80	Abnormality of glycine metabolism (HP:0010895)	1.93337760
81	Abnormality of serine family amino acid metabolism (HP:0010894)	1.93337760
82	Sensorimotor neuropathy (HP:0007141)	1.92834583
83	Resting tremor (HP:0002322)	1.92560716
84	Hypolipoproteinemia (HP:0010981)	1.92465014
85	Aortic dissection (HP:0002647)	1.92257231
86	Dysostosis multiplex (HP:0000943)	1.91369237
87	Dysmetric saccades (HP:0000641)	1.89527924
88	Polycythemia (HP:0001901)	1.88876909
89	Broad face (HP:0000283)	1.88823583
90	Vertebral compression fractures (HP:0002953)	1.88116596
91	Foot dorsiflexor weakness (HP:0009027)	1.88014432
92	Back pain (HP:0003418)	1.87958955
93	Sudden death (HP:0001699)	1.87224985
94	Cholelithiasis (HP:0001081)	1.86001279
95	Torticollis (HP:0000473)	1.85913312
96	Papilledema (HP:0001085)	1.85285129
97	Global brain atrophy (HP:0002283)	1.84910569
98	Hypobetalipoproteinemia (HP:0003563)	1.84707844
99	Hyperacusis (HP:0010780)	1.84412915
100	Hypercortisolism (HP:0001578)	1.82108076
101	Hyperglycinemia (HP:0002154)	1.81519379
102	Increased CSF protein (HP:0002922)	1.81245413
103	Achilles tendon contracture (HP:0001771)	1.80776479
104	Depression (HP:0000716)	1.80768050
105	Right ventricular cardiomyopathy (HP:0011663)	1.80530189
106	Abnormal atrioventricular conduction (HP:0005150)	1.80509724
107	Macroorchidism (HP:0000053)	1.80105318
108	Oligomenorrhea (HP:0000876)	1.79799005
109	Lower limb amyotrophy (HP:0007210)	1.78878580
110	Late onset (HP:0003584)	1.78871572
111	Thin bony cortex (HP:0002753)	1.78577460
112	Ventricular tachycardia (HP:0004756)	1.77925730
113	Frequent falls (HP:0002359)	1.77131811
114	Spastic diplegia (HP:0001264)	1.76995721
115	Abnormal gallbladder morphology (HP:0012437)	1.76238594
116	Abnormality of the intrinsic pathway (HP:0010989)	1.75769486
117	Atrioventricular block (HP:0001678)	1.75593833
118	Pheochromocytoma (HP:0002666)	1.75296854
119	Dilatation of the ascending aorta (HP:0005111)	1.75089413
120	Hypercholesterolemia (HP:0003124)	1.74764045
121	Heart block (HP:0012722)	1.73670489
122	Hypoglycemic seizures (HP:0002173)	1.73460017
123	Germ cell neoplasia (HP:0100728)	1.73008042
124	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.72912542
125	Ankyloglossia (HP:0010296)	1.72396620
126	Decreased motor nerve conduction velocity (HP:0003431)	1.71952071
127	Growth hormone excess (HP:0000845)	1.71667681
128	Hydroxyprolinuria (HP:0003080)	1.71231258
129	Abnormality of proline metabolism (HP:0010907)	1.71231258
130	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.70879229
131	Hamartoma of the eye (HP:0010568)	1.69632995
132	Postural instability (HP:0002172)	1.69608095
133	Increased connective tissue (HP:0009025)	1.69058010
134	Ventricular fibrillation (HP:0001663)	1.68133372
135	Cerebral inclusion bodies (HP:0100314)	1.67368173
136	Abnormality of the foot musculature (HP:0001436)	1.67101184
137	Axonal loss (HP:0003447)	1.66629111
138	Hyperglycemia (HP:0003074)	1.66567070
139	Esophageal varix (HP:0002040)	1.66502690
140	Onion bulb formation (HP:0003383)	1.66474603
141	Status epilepticus (HP:0002133)	1.66303827
142	Wormian bones (HP:0002645)	1.65219834
143	Rapidly progressive (HP:0003678)	1.63879995
144	Interstitial pulmonary disease (HP:0006530)	1.63879417
145	Segmental peripheral demyelination/remyelination (HP:0003481)	1.63550591
146	Cervical subluxation (HP:0003308)	1.63416214
147	Neonatal short-limb short stature (HP:0008921)	1.63200213
148	Sudden cardiac death (HP:0001645)	1.62156672
149	Spinal rigidity (HP:0003306)	1.61001458
150	Abnormality of the fingertips (HP:0001211)	1.59599814
151	Mitral regurgitation (HP:0001653)	1.59518022
152	Neuronal loss in central nervous system (HP:0002529)	1.59177255
153	Fragile skin (HP:0001030)	1.58079484
154	Bronchomalacia (HP:0002780)	1.57720901
155	Hypoplasia of the iris (HP:0007676)	1.56049249
156	Hammertoe (HP:0001765)	1.55428113
157	Aplasia involving bones of the upper limbs (HP:0009823)	1.54516281
158	Aplasia of the phalanges of the hand (HP:0009802)	1.54516281
159	Aplasia involving bones of the extremities (HP:0009825)	1.54516281
160	Bladder diverticulum (HP:0000015)	1.54030632
161	Myopathic facies (HP:0002058)	1.53618693
162	Hyperextensible skin (HP:0000974)	1.52913201
163	Abnormality of the salivary glands (HP:0010286)	1.52636099
164	Osteolytic defects of the hand bones (HP:0009699)	1.52283527
165	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.52283527
166	Asymmetry of the thorax (HP:0001555)	1.51408407
167	Atrophic scars (HP:0001075)	1.51321800
168	Neoplasm of the heart (HP:0100544)	1.49229489
169	Blue sclerae (HP:0000592)	1.49034880
170	Overgrowth (HP:0001548)	1.48553559
171	Akinesia (HP:0002304)	1.48494384
172	Hemorrhage of the eye (HP:0011885)	1.47713906
173	Metaphyseal cupping (HP:0003021)	1.46967172

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.58355645
2	PKN2	3.05133820
3	PRPF4B	2.65804342
4	ERN1	2.62175535
5	MAP3K9	2.58916917
6	KSR2	2.28371115
7	RIPK1	2.12908595
8	SIK1	2.12414373
9	LMTK2	1.97144424
10	RIPK4	1.93121629
11	CAMKK1	1.89589286
12	TTN	1.86842528
13	PDGFRA	1.79207262
14	DAPK2	1.71131731
15	NTRK1	1.69250312
16	PRKD3	1.67167224
17	FGFR4	1.62115107
18	NEK1	1.61776645
19	PTK6	1.59839408
20	RET	1.55350313
21	PAK6	1.55229732
22	MAP3K2	1.54935040
23	BCKDK	1.53538738
24	MAP2K4	1.49384789
25	CAMK1D	1.45244668
26	MARK2	1.42262280
27	PHKG1	1.41408869
28	PHKG2	1.41408869
29	NTRK3	1.34818023
30	CDK12	1.29721232
31	CAMK1G	1.21795992
32	MINK1	1.21177423
33	PRKCH	1.11624566
34	SGK3	1.11556862
35	CAMKK2	1.10128957
36	TESK1	1.09462049
37	STK38	1.09005444
38	TAOK1	1.08113780
39	MAPK12	1.05730151
40	EEF2K	1.04685061
41	MAP3K7	1.04292019
42	MAP3K4	1.04132307
43	BMX	1.01604646
44	DDR2	1.01555808
45	SCYL2	1.00175796
46	PDK3	0.99893038
47	PDK4	0.99893038
48	MAP3K3	0.99683584
49	SMG1	0.99338295
50	PAK3	0.98348429
51	JAK1	0.97011647
52	FGFR2	0.94319624
53	TGFBR2	0.93387272
54	TYRO3	0.92571048
55	ARAF	0.91190415
56	PRKD2	0.89700206
57	UHMK1	0.88837728
58	ZAP70	0.88776591
59	ALK	0.88187851
60	LATS2	0.87920536
61	JAK2	0.87599495
62	PDPK1	0.86835173
63	MAP3K1	0.86014501
64	PTK2	0.85907423
65	FER	0.85854840
66	MAP2K1	0.85419982
67	FGFR3	0.84551024
68	MARK1	0.83278278
69	EPHB1	0.82526783
70	PDK1	0.78903239
71	KSR1	0.78823696
72	MAP3K10	0.78736929
73	DMPK	0.73778025
74	HIPK2	0.73631003
75	EPHA2	0.72861968
76	FLT3	0.72074358
77	PINK1	0.69602221
78	MOS	0.68921497
79	LATS1	0.68829342
80	FRK	0.68500774
81	ICK	0.67523209
82	NEK6	0.66155506
83	NTRK2	0.65275918
84	MAP3K6	0.62780028
85	PDGFRB	0.62458587
86	CDK5	0.62180271
87	PRKAA1	0.61882300
88	MYLK	0.60162469
89	SGK494	0.59666297
90	SGK223	0.59666297
91	SIK3	0.59169231
92	EPHA4	0.58823920
93	TYK2	0.58444383
94	AKT3	0.58182705
95	MAPK7	0.57415043
96	INSRR	0.57194766
97	MAP3K11	0.56588804
98	TAOK3	0.56496884
99	TNK2	0.55842221
100	ROCK2	0.55292137
101	SIK2	0.55272054
102	RPS6KA2	0.55126616
103	FGFR1	0.54192337
104	PRKD1	0.53845959
105	PIK3CA	0.52427600
106	MET	0.52234365
107	SGK2	0.52111537
108	MAPKAPK3	0.52029325
109	DAPK1	0.50615810
110	CAMK1	0.49656434
111	PRKCZ	0.49328198
112	CSK	0.48675679
113	MTOR	0.48564569
114	WNK1	0.47144441
115	NEK9	0.46972007
116	GRK5	0.46565229
117	YES1	0.46497368
118	MAP3K13	0.46421936
119	TAOK2	0.46370434
120	EPHA3	0.46282993
121	MAPK10	0.45688994
122	MST1R	0.45606898
123	CDC42BPA	0.44547536
124	PRKACG	0.42802430
125	PTK2B	0.42619136
126	MAP2K3	0.42438972
127	CAMK4	0.41706416
128	STK11	0.41530962
129	TBK1	0.41369574
130	FYN	0.39025172
131	DYRK1B	0.38729030
132	PAK4	0.37374268
133	MAPK11	0.37351334

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.91525250
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.09110024
3	Arginine biosynthesis_Homo sapiens_hsa00220	2.29202177
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.27406611
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.02420488
6	Fatty acid degradation_Homo sapiens_hsa00071	1.96638668
7	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.79154836
8	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.74936633
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.72905833
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68840783
11	Fatty acid metabolism_Homo sapiens_hsa01212	1.62660685
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.61155245
13	Butanoate metabolism_Homo sapiens_hsa00650	1.57186155
14	PPAR signaling pathway_Homo sapiens_hsa03320	1.56308689
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.56205616
16	Bile secretion_Homo sapiens_hsa04976	1.50874823
17	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.45395712
18	Propanoate metabolism_Homo sapiens_hsa00640	1.45037482
19	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.37784030
20	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.33263986
21	Complement and coagulation cascades_Homo sapiens_hsa04610	1.31229658
22	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.30580536
23	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.23476828
24	Renal cell carcinoma_Homo sapiens_hsa05211	1.22881158
25	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.15831020
26	ErbB signaling pathway_Homo sapiens_hsa04012	1.12519662
27	Acute myeloid leukemia_Homo sapiens_hsa05221	1.08913997
28	Insulin resistance_Homo sapiens_hsa04931	1.08326397
29	Carbon metabolism_Homo sapiens_hsa01200	1.06287091
30	Type II diabetes mellitus_Homo sapiens_hsa04930	1.05554264
31	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.04641215
32	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.03023445
33	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.02560256
34	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.02148488
35	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.01227808
36	Choline metabolism in cancer_Homo sapiens_hsa05231	1.00714516
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.99566527
38	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.96096501
39	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.95969639
40	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.94012672
41	Caffeine metabolism_Homo sapiens_hsa00232	0.93815298
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.92992651
43	Notch signaling pathway_Homo sapiens_hsa04330	0.92737916
44	Pancreatic cancer_Homo sapiens_hsa05212	0.92657293
45	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.92003351
46	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.91976837
47	Amphetamine addiction_Homo sapiens_hsa05031	0.91603891
48	Thyroid cancer_Homo sapiens_hsa05216	0.90987919
49	Adherens junction_Homo sapiens_hsa04520	0.90959895
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89584874
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89216313
52	Insulin signaling pathway_Homo sapiens_hsa04910	0.89131184
53	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.85655292
54	Peroxisome_Homo sapiens_hsa04146	0.85219878
55	mTOR signaling pathway_Homo sapiens_hsa04150	0.83925653
56	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.83809560
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.83808889
58	Melanogenesis_Homo sapiens_hsa04916	0.83215218
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83121710
60	Platelet activation_Homo sapiens_hsa04611	0.81603003
61	ECM-receptor interaction_Homo sapiens_hsa04512	0.81432134
62	Gap junction_Homo sapiens_hsa04540	0.81343275
63	Glucagon signaling pathway_Homo sapiens_hsa04922	0.79010675
64	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.78257119
65	Rap1 signaling pathway_Homo sapiens_hsa04015	0.77530188
66	Pancreatic secretion_Homo sapiens_hsa04972	0.76550783
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.76243896
68	Insulin secretion_Homo sapiens_hsa04911	0.75956476
69	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.75488908
70	Osteoclast differentiation_Homo sapiens_hsa04380	0.75080377
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.74499096
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.74193190
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.72654089
74	Gastric acid secretion_Homo sapiens_hsa04971	0.72344755
75	Glioma_Homo sapiens_hsa05214	0.72043437
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71916910
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.71553469
78	AMPK signaling pathway_Homo sapiens_hsa04152	0.71347761
79	* Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.71168003
80	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71138084
81	Cocaine addiction_Homo sapiens_hsa05030	0.71109033
82	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.70922492
83	Lysosome_Homo sapiens_hsa04142	0.70772956
84	Phenylalanine metabolism_Homo sapiens_hsa00360	0.70533032
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.70285697
86	Hepatitis C_Homo sapiens_hsa05160	0.69175291
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.68771099
88	Chemokine signaling pathway_Homo sapiens_hsa04062	0.68487400
89	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.68390836
90	Prion diseases_Homo sapiens_hsa05020	0.68212598
91	Olfactory transduction_Homo sapiens_hsa04740	0.67519630
92	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.66349017
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.66143983
94	Tight junction_Homo sapiens_hsa04530	0.65944125
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65801929
96	ABC transporters_Homo sapiens_hsa02010	0.65272444
97	Lysine degradation_Homo sapiens_hsa00310	0.64972247
98	Long-term depression_Homo sapiens_hsa04730	0.64233754
99	Axon guidance_Homo sapiens_hsa04360	0.64133892
100	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.63796611
101	Other glycan degradation_Homo sapiens_hsa00511	0.62268576
102	MAPK signaling pathway_Homo sapiens_hsa04010	0.61980005
103	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.60799456
104	Vibrio cholerae infection_Homo sapiens_hsa05110	0.60080673
105	GABAergic synapse_Homo sapiens_hsa04727	0.59387009
106	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.59106025
107	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.58839260
108	Protein digestion and absorption_Homo sapiens_hsa04974	0.58812420
109	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.58622303
110	FoxO signaling pathway_Homo sapiens_hsa04068	0.58598268
111	Prostate cancer_Homo sapiens_hsa05215	0.58267028
112	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56544360
113	Circadian entrainment_Homo sapiens_hsa04713	0.55239646
114	Long-term potentiation_Homo sapiens_hsa04720	0.54649433
115	Salivary secretion_Homo sapiens_hsa04970	0.51793744
116	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.51722747
117	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.51719263
118	Renin secretion_Homo sapiens_hsa04924	0.51536030
119	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.50500127
120	Selenocompound metabolism_Homo sapiens_hsa00450	0.50190162
121	Endometrial cancer_Homo sapiens_hsa05213	0.50138273
122	Cholinergic synapse_Homo sapiens_hsa04725	0.48519956
123	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.48123798
124	Non-small cell lung cancer_Homo sapiens_hsa05223	0.47396425
125	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.47303502
126	VEGF signaling pathway_Homo sapiens_hsa04370	0.47138285
127	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47105154
128	GnRH signaling pathway_Homo sapiens_hsa04912	0.44658903
129	Focal adhesion_Homo sapiens_hsa04510	0.44307176
130	Dopaminergic synapse_Homo sapiens_hsa04728	0.43263362
131	Proteoglycans in cancer_Homo sapiens_hsa05205	0.42974218
132	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.42522429
133	Tyrosine metabolism_Homo sapiens_hsa00350	0.42185112
134	Histidine metabolism_Homo sapiens_hsa00340	0.41636056
135	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.41056599
136	Prolactin signaling pathway_Homo sapiens_hsa04917	0.40942722
137	Sulfur metabolism_Homo sapiens_hsa00920	0.40825782
138	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.39820469
139	* Amoebiasis_Homo sapiens_hsa05146	0.39721999
140	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.38630172
141	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38509357
142	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38154307
143	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37744226
144	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.36813387
145	* Endocytosis_Homo sapiens_hsa04144	0.35879479

RAB5B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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