RAB5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.74237102
2barbed-end actin filament capping (GO:0051016)3.99824899
3low-density lipoprotein particle clearance (GO:0034383)3.91280233
4negative regulation of erythrocyte differentiation (GO:0045647)3.86559901
5response to peptidoglycan (GO:0032494)3.76296918
6pinocytosis (GO:0006907)3.51616849
7Golgi transport vesicle coating (GO:0048200)3.49465765
8COPI coating of Golgi vesicle (GO:0048205)3.49465765
9apoptotic cell clearance (GO:0043277)3.44488458
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38345697
11pentose-phosphate shunt (GO:0006098)3.35991929
12cortical actin cytoskeleton organization (GO:0030866)3.30938524
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28425280
14negative regulation of cell killing (GO:0031342)3.28425280
15positive regulation of histone deacetylation (GO:0031065)3.26796192
16response to laminar fluid shear stress (GO:0034616)3.25514085
17NADPH regeneration (GO:0006740)3.21784699
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.19678313
19regulation of cholesterol homeostasis (GO:2000188)3.14449318
20regulation of cholesterol storage (GO:0010885)3.14346090
21cysteine metabolic process (GO:0006534)3.13070797
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12855858
23neutrophil activation involved in immune response (GO:0002283)3.10332797
24positive regulation by symbiont of host defense response (GO:0052509)3.07827228
25modulation by symbiont of host defense response (GO:0052031)3.07827228
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07827228
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07827228
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.07827228
29modulation by symbiont of host immune response (GO:0052553)3.07827228
30regulation of leukocyte degranulation (GO:0043300)3.02658634
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01587304
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01587304
33negative regulation of interleukin-12 production (GO:0032695)3.01339347
34glycosphingolipid catabolic process (GO:0046479)3.00812643
35macrophage activation involved in immune response (GO:0002281)2.99935376
36alpha-linolenic acid metabolic process (GO:0036109)2.94300764
37lysine metabolic process (GO:0006553)2.92018621
38lysine catabolic process (GO:0006554)2.92018621
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.91591831
40regulation of mast cell degranulation (GO:0043304)2.87532743
41cell adhesion mediated by integrin (GO:0033627)2.87030744
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86761654
43cortical cytoskeleton organization (GO:0030865)2.85999307
44regulation of early endosome to late endosome transport (GO:2000641)2.83876189
45NIK/NF-kappaB signaling (GO:0038061)2.82216041
46skin morphogenesis (GO:0043589)2.81415336
47maternal placenta development (GO:0001893)2.79689107
48adhesion of symbiont to host cell (GO:0044650)2.77248208
49virion attachment to host cell (GO:0019062)2.77248208
50positive regulation of p38MAPK cascade (GO:1900745)2.75817792
51regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75535947
52positive regulation of gamma-delta T cell activation (GO:0046645)2.75329760
53detection of other organism (GO:0098543)2.74987782
54plasma lipoprotein particle clearance (GO:0034381)2.74941886
55positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73625312
56protein retention in ER lumen (GO:0006621)2.72609109
57regulation of defense response to virus by virus (GO:0050690)2.72327907
58cell-substrate junction assembly (GO:0007044)2.71774839
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.71479169
60regulation of p38MAPK cascade (GO:1900744)2.70126578
61adhesion of symbiont to host (GO:0044406)2.69929653
62regulation of T-helper 2 cell differentiation (GO:0045628)2.68260227
63modulation by symbiont of host cellular process (GO:0044068)2.68146254
64glycolipid catabolic process (GO:0019377)2.66440472
65response to muramyl dipeptide (GO:0032495)2.66213860
66immunoglobulin mediated immune response (GO:0016064)2.66132812
67detection of molecule of bacterial origin (GO:0032490)2.64725272
68positive regulation of Rho protein signal transduction (GO:0035025)2.63599032
69stress fiber assembly (GO:0043149)2.63511428
70regulation of superoxide anion generation (GO:0032928)2.63251369
71amino sugar catabolic process (GO:0046348)2.61877743
72detection of bacterium (GO:0016045)2.60699506
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60383976
74cellular response to thyroid hormone stimulus (GO:0097067)2.59033902
75antigen processing and presentation of endogenous antigen (GO:0019883)2.57166647
76regulation of fatty acid beta-oxidation (GO:0031998)2.56603596
77detection of external biotic stimulus (GO:0098581)2.54736657
78regulation of extracellular matrix disassembly (GO:0010715)2.54206579
79receptor catabolic process (GO:0032801)2.53444995
80regulation of membrane protein ectodomain proteolysis (GO:0051043)2.52220485
81semaphorin-plexin signaling pathway (GO:0071526)2.52148855
82positive regulation of leukocyte degranulation (GO:0043302)2.51820336
83basement membrane organization (GO:0071711)2.50441851
84adherens junction assembly (GO:0034333)2.50406398
85positive regulation of extracellular matrix organization (GO:1903055)2.48503199
86regulation of interferon-beta biosynthetic process (GO:0045357)2.47310227
87positive regulation of cellular amide metabolic process (GO:0034250)2.46524626
88regulation of mast cell activation involved in immune response (GO:0033006)2.46432058
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.46409600
90L-phenylalanine metabolic process (GO:0006558)2.46409600
91response to thyroid hormone (GO:0097066)2.45893607
92hyaluronan catabolic process (GO:0030214)2.45654347
93sulfur amino acid catabolic process (GO:0000098)2.45322094
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42065827
95regulation of regulated secretory pathway (GO:1903305)2.41585333
96glyoxylate metabolic process (GO:0046487)2.41065857
97focal adhesion assembly (GO:0048041)2.41045284
98cell-substrate adherens junction assembly (GO:0007045)2.41045284
99negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.41009742
100positive regulation of triglyceride metabolic process (GO:0090208)2.40980509
101NADP metabolic process (GO:0006739)2.40557096
102growth hormone receptor signaling pathway (GO:0060396)2.38965185
103negative regulation of cell size (GO:0045792)2.38772197
104myeloid dendritic cell differentiation (GO:0043011)2.37125454
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36013596
106response to host (GO:0075136)2.36013596
107response to host defenses (GO:0052200)2.36013596
108drug transmembrane transport (GO:0006855)2.35370420
109myelin maintenance (GO:0043217)2.35215261
110endocytic recycling (GO:0032456)2.35137221
111modulation by virus of host process (GO:0019054)2.33843877
112oligosaccharide catabolic process (GO:0009313)2.33207939
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.32890701
114positive regulation of receptor recycling (GO:0001921)2.32602557
115L-phenylalanine catabolic process (GO:0006559)2.32317915
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32317915
117positive regulation of triglyceride biosynthetic process (GO:0010867)2.32240055
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31167444
119response to host immune response (GO:0052572)2.30439512
120response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30439512
121regulation of clathrin-mediated endocytosis (GO:2000369)2.29947185
122urate metabolic process (GO:0046415)2.28582075
123germ cell migration (GO:0008354)2.27895696
124L-alpha-amino acid transmembrane transport (GO:1902475)2.26940249
1254-hydroxyproline metabolic process (GO:0019471)2.26689866
126detection of biotic stimulus (GO:0009595)2.26608971
127cellular modified amino acid catabolic process (GO:0042219)2.25949130
128mannose metabolic process (GO:0006013)2.25817657
129negative regulation of smooth muscle cell migration (GO:0014912)2.25225440
130germinal center formation (GO:0002467)2.25040994
131fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24972793
132hemidesmosome assembly (GO:0031581)2.24916188
133glutamate metabolic process (GO:0006536)2.24314980
134response to growth hormone (GO:0060416)2.23907140
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.23189776
136antigen processing and presentation via MHC class Ib (GO:0002475)2.22647031
137protein carboxylation (GO:0018214)2.21668613
138peptidyl-glutamic acid carboxylation (GO:0017187)2.21668613
139cellular response to type I interferon (GO:0071357)2.21037995
140type I interferon signaling pathway (GO:0060337)2.21037995
141granulocyte activation (GO:0036230)2.19721440
142apoptotic process involved in morphogenesis (GO:0060561)2.19305140
143embryonic process involved in female pregnancy (GO:0060136)2.19068725
144glucose 6-phosphate metabolic process (GO:0051156)2.18602880
145negative regulation of cholesterol transport (GO:0032375)2.18223646
146negative regulation of sterol transport (GO:0032372)2.18223646
147positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.17869647
148regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.17309290
149response to type I interferon (GO:0034340)2.17128437
150response to fluid shear stress (GO:0034405)2.17074952
151negative regulation of fibrinolysis (GO:0051918)2.16514536
152cellular response to arsenic-containing substance (GO:0071243)2.16122631
153triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.16028134
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.15957789
155regulation of macrophage cytokine production (GO:0010935)2.14541563
156regulation of ARF GTPase activity (GO:0032312)2.14082517
157sodium ion export (GO:0071436)2.13650004
158negative regulation of lipid transport (GO:0032369)2.13403084
159response to mercury ion (GO:0046689)2.13334632
160respiratory burst (GO:0045730)2.12311953
161aspartate family amino acid catabolic process (GO:0009068)2.09899035
162amyloid precursor protein catabolic process (GO:0042987)2.09829482
163glucose catabolic process (GO:0006007)2.08642360
164Arp2/3 complex-mediated actin nucleation (GO:0034314)2.08581063
165protein-lipid complex assembly (GO:0065005)2.07965975
166negative regulation of cytokine production involved in immune response (GO:0002719)2.07619408
167cellular response to growth hormone stimulus (GO:0071378)2.07368314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.02453401
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46504532
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20718895
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09291016
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.80526319
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.70596765
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.56531076
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.54686038
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51954314
10ZNF263_19887448_ChIP-Seq_K562_Human2.36884566
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.29985857
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29538572
13LXR_22292898_ChIP-Seq_THP-1_Human2.26425154
14CLOCK_20551151_ChIP-Seq_293T_Human2.25714496
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23901322
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17904814
17KDM2B_26808549_Chip-Seq_DND41_Human2.14640361
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.14634792
19VDR_21846776_ChIP-Seq_THP-1_Human2.12101010
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.11105750
21RACK7_27058665_Chip-Seq_MCF-7_Human2.07176354
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.94936851
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93255262
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93222026
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87704700
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87683649
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.85883753
28MYC_22102868_ChIP-Seq_BL_Human1.79393981
29TCF7_22412390_ChIP-Seq_EML_Mouse1.77996088
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71148186
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70935839
32* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66431621
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66032918
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.65370916
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.64840588
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62496486
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61216141
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61167145
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60919019
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60136513
41KDM2B_26808549_Chip-Seq_K562_Human1.57673316
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.54967590
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54744298
44* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54498367
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.52048970
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48532931
47MAF_26560356_Chip-Seq_TH1_Human1.48481631
48ATF3_27146783_Chip-Seq_COLON_Human1.48398956
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47927747
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45127680
51* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45064332
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44792673
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43061952
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42591418
55* IRF8_27001747_Chip-Seq_BMDM_Mouse1.42220655
56VDR_24763502_ChIP-Seq_THP-1_Human1.39773085
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36540483
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.35958069
59* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35220353
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34497004
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34218109
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33810938
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31924257
64UTX_26944678_Chip-Seq_JUKART_Human1.31709584
65GATA1_19941826_ChIP-Seq_K562_Human1.31204038
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27319960
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25584191
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24783872
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24253754
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23414172
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23133584
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22894424
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22669000
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22401194
75* GATA1_19941827_ChIP-Seq_MEL_Mouse1.21370898
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.20767821
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20740371
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20666015
79CREB1_26743006_Chip-Seq_LNCaP_Human1.20485825
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.18767200
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.18689748
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18509960
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18332099
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17667587
85* SPI1_23547873_ChIP-Seq_NB4_Human1.17290829
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16777279
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12680453
88BCOR_27268052_Chip-Seq_Bcells_Human1.12402830
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12179028
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12086920
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10439835
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10429123
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10191984
94SMC4_20622854_ChIP-Seq_HELA_Human1.09577891
95BCL6_27268052_Chip-Seq_Bcells_Human1.08990541
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08549621
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08450359
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07785908
99NCOR1_26117541_ChIP-Seq_K562_Human1.06738958
100TP53_22127205_ChIP-Seq_IMR90_Human1.06302321
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06263170
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.06156401
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06065122
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05262704
105RUNX1_27514584_Chip-Seq_MCF-7_Human1.05016201
106GATA6_25053715_ChIP-Seq_YYC3_Human1.04160349
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03767558
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03079309
109GATA2_19941826_ChIP-Seq_K562_Human1.02505829
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02387577
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02195143
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02167953
113MAF_26560356_Chip-Seq_TH2_Human1.01759905
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99258641
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98943824
116* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98589071
117SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98489777
118* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98390224
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96767318
120* SPI1_23127762_ChIP-Seq_K562_Human0.96750281
121P68_20966046_ChIP-Seq_HELA_Human0.96733747
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96088502
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.94573270
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.94433005
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.94433005
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.93547453
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.92714315
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92655028
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92481103
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91461226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.83723435
2MP0003303_peritoneal_inflammation3.47409462
3MP0003300_gastrointestinal_ulcer3.38685560
4MP0005360_urolithiasis3.32846668
5MP0009840_abnormal_foam_cell3.15634851
6MP0008438_abnormal_cutaneous_collagen2.81094052
7MP0005451_abnormal_body_composition2.74313445
8MP0005058_abnormal_lysosome_morphology2.71560034
9MP0002139_abnormal_hepatobiliary_system2.56497881
10MP0004185_abnormal_adipocyte_glucose2.49376856
11MP0003724_increased_susceptibility_to2.30444226
12MP0003191_abnormal_cellular_cholesterol2.25779469
13MP0008260_abnormal_autophagy2.23286841
14MP0003566_abnormal_cell_adhesion2.10914024
15MP0010234_abnormal_vibrissa_follicle2.08463113
16MP0003172_abnormal_lysosome_physiology2.02272043
17MP0010352_gastrointestinal_tract_polyps1.97356071
18MP0001835_abnormal_antigen_presentation1.96103508
19MP0005025_abnormal_response_to1.91322498
20MP0001958_emphysema1.80639945
21MP0002148_abnormal_hypersensitivity_rea1.80239102
22MP0000604_amyloidosis1.77626696
23MP0009785_altered_susceptibility_to1.75984600
24MP0002138_abnormal_hepatobiliary_system1.69131345
25MP0002877_abnormal_melanocyte_morpholog1.65833922
26MP0002796_impaired_skin_barrier1.64333340
27MP0003329_amyloid_beta_deposits1.62843899
28MP0003453_abnormal_keratinocyte_physiol1.62842892
29MP0006082_CNS_inflammation1.61659651
30MP0003690_abnormal_glial_cell1.61563040
31MP0003279_aneurysm1.58042104
32MP0005076_abnormal_cell_differentiation1.57303201
33MP0009333_abnormal_splenocyte_physiolog1.57137793
34MP0005083_abnormal_biliary_tract1.55955940
35MP0009278_abnormal_bone_marrow1.55694769
36MP0004947_skin_inflammation1.52485688
37MP0005023_abnormal_wound_healing1.48882733
38MP0003436_decreased_susceptibility_to1.47592875
39MP0004510_myositis1.43131593
40MP0003075_altered_response_to1.43005946
41MP0005623_abnormal_meninges_morphology1.42378289
42MP0004858_abnormal_nervous_system1.42322927
43MP0002452_abnormal_antigen_presenting1.41812706
44MP0010329_abnormal_lipoprotein_level1.40716634
45MP0002723_abnormal_immune_serum1.39860764
46MP0003252_abnormal_bile_duct1.38606675
47MP0005666_abnormal_adipose_tissue1.37849553
48MP0005332_abnormal_amino_acid1.37053826
49MP0001849_ear_inflammation1.35045786
50MP0010155_abnormal_intestine_physiology1.32854209
51MP0002420_abnormal_adaptive_immunity1.32170536
52MP0001819_abnormal_immune_cell1.32101362
53MP0005275_abnormal_skin_tensile1.31878646
54MP0009643_abnormal_urine_homeostasis1.30397207
55MP0000733_abnormal_muscle_development1.27248641
56MP0008875_abnormal_xenobiotic_pharmacok1.27121981
57MP0003091_abnormal_cell_migration1.25001157
58MP0003828_pulmonary_edema1.24836271
59MP0001853_heart_inflammation1.24389709
60MP0008961_abnormal_basal_metabolism1.24129661
61MP0002254_reproductive_system_inflammat1.24034996
62MP0001800_abnormal_humoral_immune1.23093017
63MP0003183_abnormal_peptide_metabolism1.22173107
64MP0000609_abnormal_liver_physiology1.21425446
65MP0005375_adipose_tissue_phenotype1.20078191
66MP0003656_abnormal_erythrocyte_physiolo1.19998809
67MP0005671_abnormal_response_to1.19762066
68MP0004272_abnormal_basement_membrane1.18713750
69MP0000920_abnormal_myelination1.17527009
70MP0005409_darkened_coat_color1.16955803
71MP0005085_abnormal_gallbladder_physiolo1.15747912
72MP0001851_eye_inflammation1.15487742
73MP0000678_abnormal_parathyroid_gland1.13279931
74MP0002405_respiratory_system_inflammati1.11757411
75MP0005390_skeleton_phenotype1.11690655
76MP0005464_abnormal_platelet_physiology1.11679557
77MP0000685_abnormal_immune_system1.11004934
78MP0003448_altered_tumor_morphology1.10718083
79MP0001533_abnormal_skeleton_physiology1.10334831
80MP0005501_abnormal_skin_physiology1.08388793
81MP0005167_abnormal_blood-brain_barrier1.07435813
82MP0002136_abnormal_kidney_physiology1.06006735
83MP0004019_abnormal_vitamin_homeostasis1.04069284
84MP0002060_abnormal_skin_morphology1.02756836
85MP0002118_abnormal_lipid_homeostasis1.01217966
86MP0009764_decreased_sensitivity_to0.99151179
87MP0000716_abnormal_immune_system0.95375696
88MP0001545_abnormal_hematopoietic_system0.95161632
89MP0005397_hematopoietic_system_phenotyp0.95161632
90MP0005165_increased_susceptibility_to0.93766558
91MP0001756_abnormal_urination0.93433491
92MP0000767_abnormal_smooth_muscle0.93351374
93MP0003763_abnormal_thymus_physiology0.93138730
94MP0010368_abnormal_lymphatic_system0.93041334
95MP0005365_abnormal_bile_salt0.92341658
96MP0005164_abnormal_response_to0.90977597
97MP0000465_gastrointestinal_hemorrhage0.90676505
98MP0004130_abnormal_muscle_cell0.90249624
99MP0001542_abnormal_bone_strength0.89324769
100MP0004233_abnormal_muscle_weight0.88677363
101MP0003045_fibrosis0.88510178
102MP0008004_abnormal_stomach_pH0.88040336
103MP0002398_abnormal_bone_marrow0.87246446
104MP0003795_abnormal_bone_structure0.86147876
105MP0005319_abnormal_enzyme/_coenzyme0.85058071
106MP0010678_abnormal_skin_adnexa0.84962959
107MP0000681_abnormal_thyroid_gland0.84701761
108MP0005257_abnormal_intraocular_pressure0.84542985
109MP0005584_abnormal_enzyme/coenzyme_acti0.84445306
110MP0000003_abnormal_adipose_tissue0.83707174
111MP0002429_abnormal_blood_cell0.83705660
112MP0001790_abnormal_immune_system0.83346697
113MP0005387_immune_system_phenotype0.83346697
114MP0001216_abnormal_epidermal_layer0.81276573
115MP0005166_decreased_susceptibility_to0.80573700
116MP0000343_altered_response_to0.80390843
117MP0002419_abnormal_innate_immunity0.80072511
118MP0000467_abnormal_esophagus_morphology0.79830328
119MP0000249_abnormal_blood_vessel0.79177840
120MP0001666_abnormal_nutrient_absorption0.78773912
121MP0002998_abnormal_bone_remodeling0.78440550
122MP0001915_intracranial_hemorrhage0.78407006
123MP0000490_abnormal_crypts_of0.78256412
124MP0003866_abnormal_defecation0.77877193
125MP0001348_abnormal_lacrimal_gland0.77658063
126MP0002971_abnormal_brown_adipose0.75537708
127MP0000377_abnormal_hair_follicle0.75508056
128MP0002722_abnormal_immune_system0.75062810
129MP0002933_joint_inflammation0.74830095
130MP0009384_cardiac_valve_regurgitation0.74719934
131MP0008874_decreased_physiological_sensi0.73680688
132MP0002168_other_aberrant_phenotype0.73561858
133MP0000858_altered_metastatic_potential0.73543638
134MP0009931_abnormal_skin_appearance0.73531458
135MP0003634_abnormal_glial_cell0.72297537
136MP0004883_abnormal_blood_vessel0.72185217
137MP0000598_abnormal_liver_morphology0.71796809
138MP0009053_abnormal_anal_canal0.71628704
139MP0008469_abnormal_protein_level0.71271449
140MP0002135_abnormal_kidney_morphology0.69789512
141MP0004885_abnormal_endolymph0.68738333
142MP0010771_integument_phenotype0.68525119
143MP0005000_abnormal_immune_tolerance0.68008715
144MP0010307_abnormal_tumor_latency0.66682750
145MP0002896_abnormal_bone_mineralization0.66065125
146MP0001845_abnormal_inflammatory_respons0.64825546

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)3.60317780
2Premature rupture of membranes (HP:0001788)3.39134285
3Deep venous thrombosis (HP:0002625)3.27014191
4Recurrent abscess formation (HP:0002722)3.09534661
5Increased cerebral lipofuscin (HP:0011813)3.07567113
6Dysostosis multiplex (HP:0000943)3.03925933
7Recurrent bacterial skin infections (HP:0005406)2.97465275
8Xanthomatosis (HP:0000991)2.94276844
9Cerebral aneurysm (HP:0004944)2.88456148
10Abnormality of the Achilles tendon (HP:0005109)2.85713545
11Cerebral inclusion bodies (HP:0100314)2.81328581
12Urinary glycosaminoglycan excretion (HP:0003541)2.78794005
13Mucopolysacchariduria (HP:0008155)2.78794005
14Achilles tendon contracture (HP:0001771)2.75650406
15Neurofibrillary tangles (HP:0002185)2.75520997
16Peritonitis (HP:0002586)2.70076716
17Systemic lupus erythematosus (HP:0002725)2.69209759
18Axonal loss (HP:0003447)2.68874681
19Protrusio acetabuli (HP:0003179)2.64978834
20Myocardial infarction (HP:0001658)2.59955491
21Purpura (HP:0000979)2.55041483
22Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50453445
23Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50453445
24Abnormality of polysaccharide metabolism (HP:0011012)2.50453445
25Myositis (HP:0100614)2.50124672
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46538909
27Complement deficiency (HP:0004431)2.41226655
28Interstitial pulmonary disease (HP:0006530)2.40551097
29Vacuolated lymphocytes (HP:0001922)2.38528341
30Orchitis (HP:0100796)2.37113584
31Polycythemia (HP:0001901)2.36850926
32Cellulitis (HP:0100658)2.33657139
33Mitral valve prolapse (HP:0001634)2.31557012
34Distal upper limb amyotrophy (HP:0007149)2.31282052
35Upper limb amyotrophy (HP:0009129)2.31282052
36Obstructive lung disease (HP:0006536)2.28519672
37Chronic obstructive pulmonary disease (HP:0006510)2.28519672
38Shallow orbits (HP:0000586)2.26555113
39Disproportionate tall stature (HP:0001519)2.21853619
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.20042508
41Abnormality of complement system (HP:0005339)2.14658658
42Spastic diplegia (HP:0001264)2.13244883
43Ulnar bowing (HP:0003031)2.12468104
44Genu recurvatum (HP:0002816)2.12365961
45Polygenic inheritance (HP:0010982)2.11089194
46Global brain atrophy (HP:0002283)2.09956751
47Hyperacusis (HP:0010780)2.09884667
48Loss of speech (HP:0002371)2.08040869
49Increased serum ferritin (HP:0003281)2.07233175
50Nuclear cataract (HP:0100018)2.06928495
51Segmental peripheral demyelination/remyelination (HP:0003481)2.06867500
52Spontaneous hematomas (HP:0007420)2.06834461
53Gingivitis (HP:0000230)2.06632633
54Mediastinal lymphadenopathy (HP:0100721)2.06150195
55Increased IgE level (HP:0003212)2.05206086
56Distal lower limb muscle weakness (HP:0009053)2.04829190
57Supranuclear gaze palsy (HP:0000605)2.02537160
58Hypokalemic alkalosis (HP:0001949)2.02377473
59Back pain (HP:0003418)2.02371735
60Hydroxyprolinuria (HP:0003080)2.01953280
61Abnormality of proline metabolism (HP:0010907)2.01953280
62Petechiae (HP:0000967)2.01825321
63Abnormality of the distal phalanges of the toes (HP:0010182)2.00591391
64Thin bony cortex (HP:0002753)1.99795688
65Lymphangioma (HP:0100764)1.99109129
66Osteolytic defects of the hand bones (HP:0009699)1.97322050
67Osteolytic defects of the phalanges of the hand (HP:0009771)1.97322050
68Hand muscle atrophy (HP:0009130)1.97240491
69Aortic dissection (HP:0002647)1.95987593
70Increased density of long bones (HP:0006392)1.95070325
71Distal lower limb amyotrophy (HP:0008944)1.94706286
72Gout (HP:0001997)1.93483776
73Abnormality of the nasal mucosa (HP:0000433)1.93020664
74Reticulocytosis (HP:0001923)1.91958648
75J-shaped sella turcica (HP:0002680)1.91753387
76Hyperparathyroidism (HP:0000843)1.90945267
77Bone pain (HP:0002653)1.89544413
78Progressive neurologic deterioration (HP:0002344)1.89208186
79Elevated erythrocyte sedimentation rate (HP:0003565)1.88619224
80Hepatosplenomegaly (HP:0001433)1.88476109
81Increased circulating renin level (HP:0000848)1.87527333
82Peripheral demyelination (HP:0011096)1.86270892
83Hypertensive crisis (HP:0100735)1.85555372
84Diminished motivation (HP:0000745)1.84957267
85Nephritis (HP:0000123)1.82674009
86Increased CSF protein (HP:0002922)1.82356979
87Abnormality of glycolipid metabolism (HP:0010969)1.82263291
88Abnormality of liposaccharide metabolism (HP:0010968)1.82263291
89Abnormality of glycosphingolipid metabolism (HP:0004343)1.82263291
90Abnormality of iron homeostasis (HP:0011031)1.82098846
91Apathy (HP:0000741)1.81800129
92Esophageal varix (HP:0002040)1.81483502
93Neuronal loss in central nervous system (HP:0002529)1.80879780
94Increased connective tissue (HP:0009025)1.79863452
95Broad face (HP:0000283)1.79361271
96Hemorrhage of the eye (HP:0011885)1.79002922
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78990482
98Glomerulonephritis (HP:0000099)1.78952027
99Pathologic fracture (HP:0002756)1.78797659
100Hematochezia (HP:0002573)1.77622808
101Abnormal platelet function (HP:0011869)1.77382172
102Impaired platelet aggregation (HP:0003540)1.77382172
103Eczematoid dermatitis (HP:0000976)1.77206464
104Abnormality of macrophages (HP:0004311)1.75972930
105Intrahepatic cholestasis (HP:0001406)1.75465053
106Focal segmental glomerulosclerosis (HP:0000097)1.75310898
107Spondylolisthesis (HP:0003302)1.75169555
108Recurrent skin infections (HP:0001581)1.75060174
109Mitral stenosis (HP:0001718)1.74924841
110Nasal polyposis (HP:0100582)1.74405447
111Flat acetabular roof (HP:0003180)1.74140392
112Sensorimotor neuropathy (HP:0007141)1.73898555
113Multiple lipomas (HP:0001012)1.73502181
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73272499
115Upper motor neuron abnormality (HP:0002127)1.71969851
116Joint stiffness (HP:0001387)1.71861264
117Hypertriglyceridemia (HP:0002155)1.70947544
118Abnormal hemoglobin (HP:0011902)1.70665031
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69114695
120Amyloidosis (HP:0011034)1.68525822
121Visceral angiomatosis (HP:0100761)1.68365677
122Aortic aneurysm (HP:0004942)1.68220566
123Dilatation of the ascending aorta (HP:0005111)1.68169115
124Abnormality of transition element cation homeostasis (HP:0011030)1.67876599
125Thoracic kyphosis (HP:0002942)1.67655776
126Aneurysm (HP:0002617)1.67631839
127Asymmetric septal hypertrophy (HP:0001670)1.67608798
128Prolonged neonatal jaundice (HP:0006579)1.67289603
129Centrally nucleated skeletal muscle fibers (HP:0003687)1.66786834
130Retrobulbar optic neuritis (HP:0100654)1.66748116
131Optic neuritis (HP:0100653)1.66748116
132Metabolic alkalosis (HP:0200114)1.66458849
133Cervical subluxation (HP:0003308)1.66029503
134Pseudobulbar signs (HP:0002200)1.65631007
135Blue sclerae (HP:0000592)1.65618580
136Atrophic scars (HP:0001075)1.65475391
137Epistaxis (HP:0000421)1.64778668
138Protuberant abdomen (HP:0001538)1.64663077
139Hyporeflexia of lower limbs (HP:0002600)1.64616360
140Abnormality of the thoracic spine (HP:0100711)1.63796657
141Turricephaly (HP:0000262)1.63298654
142Mesangial abnormality (HP:0001966)1.62994693
143Fragile skin (HP:0001030)1.62681276
144Glomerulosclerosis (HP:0000096)1.62146634
145Obstructive sleep apnea (HP:0002870)1.61540906
146Recurrent gram-negative bacterial infections (HP:0005420)1.59684742
147Urticaria (HP:0001025)1.58007609
148Abnormality of purine metabolism (HP:0004352)1.57142201
149Bladder diverticulum (HP:0000015)1.56605740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.04780185
2ERN13.26070524
3PKN23.25125168
4PRPF4B3.07811482
5IRAK33.05071330
6EEF2K2.97991281
7EPHB12.90064034
8SMG12.73303341
9LRRK22.31027896
10NME22.20871518
11BMX2.10155919
12ICK2.02913709
13RIPK41.93321889
14TAOK21.89203168
15PTK61.84465213
16MAP3K101.83454662
17RIPK11.60799816
18SIK11.56680121
19KSR21.55853762
20STK101.53287709
21IRAK41.51050037
22MAP4K11.45619011
23TTN1.45133361
24MST1R1.39840657
25FGFR41.38725284
26WNK41.38294885
27TESK21.37471821
28PDGFRA1.37458957
29CAMK1D1.36569466
30MAP3K141.31945845
31GRK61.31199881
32MET1.30356350
33ARAF1.28463607
34ALK1.28455986
35PAK41.25009622
36CAMK1G1.23496022
37BLK1.21216792
38TYRO31.20766393
39TBK11.20007277
40PAK21.19391995
41MAP3K91.16555997
42MAP3K131.15323553
43TGFBR21.13826331
44STK391.12019313
45PTK21.08711750
46CDC42BPA1.06693546
47RET1.06643972
48ILK1.06553924
49FGR1.05081491
50CSK1.03726713
51EPHA21.03683135
52CDK61.01839020
53DDR21.01279908
54RPS6KB21.01225974
55MAP3K20.99584554
56SCYL20.98124787
57TYK20.95679222
58FES0.94221578
59JAK30.93433905
60EPHB20.92356762
61OXSR10.88561497
62NTRK10.87978494
63SIK30.87141730
64TAOK10.84644030
65PTK2B0.84244968
66MATK0.82818584
67PAK60.82469074
68DYRK1B0.82212347
69MAP2K20.77903730
70MAP3K110.73073005
71MARK20.72335221
72RPS6KA20.72302082
73IRAK20.71567845
74PDGFRB0.71350661
75JAK20.70775155
76PRKD10.70767614
77HIPK20.70500547
78MAPK110.69851895
79GSK3A0.69003972
80ROCK20.67721018
81PDPK10.65841901
82MAP3K80.65805727
83HCK0.65109381
84MOS0.64859071
85MAP2K30.64823415
86MTOR0.64192628
87MAPKAPK30.64176064
88MAP3K60.62039211
89MAP3K30.61799960
90CAMKK10.60684518
91TESK10.60665498
92ABL20.60207557
93KIT0.58997259
94STK30.57178813
95PDK10.56758552
96JAK10.55582318
97LATS20.55493944
98MAP3K10.55065848
99PRKCH0.54407550
100DMPK0.54205174
101EGFR0.53605877
102RPS6KL10.53518619
103RPS6KC10.53518619
104CDK120.53306356
105IKBKE0.53099473
106FGFR20.52726080
107PIM20.52271931
108MAP2K10.52110679
109DAPK30.52028109
110MAPKAPK20.49283715
111PAK10.47643393
112KDR0.47010524
113ZAP700.46866401
114SIK20.46354963
115IKBKB0.45805180
116CSF1R0.45783057
117TNK20.45148417
118STK110.44985576
119PRKG20.44510074
120LIMK10.44040460
121PRKD30.42515601
122MAP3K70.42141459
123BTK0.41975429
124FYN0.41810316
125BRAF0.41546826
126FGFR30.40044179
127PRKD20.39922857
128STK380.39802990
129GRK70.39501004
130SRC0.38521432
131WNK10.37924697
132MAPK120.37815238
133LMTK20.37463337
134NEK90.36292549

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.76146141
2Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84165557
3Staphylococcus aureus infection_Homo sapiens_hsa051501.76861363
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76710380
5Arginine biosynthesis_Homo sapiens_hsa002201.74044180
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70328023
7Lysosome_Homo sapiens_hsa041421.68314706
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64030896
9PPAR signaling pathway_Homo sapiens_hsa033201.60993854
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.46374019
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.44465149
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41831012
13Chronic myeloid leukemia_Homo sapiens_hsa052201.41110645
14Bile secretion_Homo sapiens_hsa049761.39827774
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.37183790
16TNF signaling pathway_Homo sapiens_hsa046681.35294374
17Renal cell carcinoma_Homo sapiens_hsa052111.33525323
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31098418
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29883794
20Fatty acid degradation_Homo sapiens_hsa000711.28576243
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27538270
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25156147
23Galactose metabolism_Homo sapiens_hsa000521.24863389
24Complement and coagulation cascades_Homo sapiens_hsa046101.24570176
25Bladder cancer_Homo sapiens_hsa052191.24006681
26* Phagosome_Homo sapiens_hsa041451.23879159
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.23224663
28Dorso-ventral axis formation_Homo sapiens_hsa043201.19567881
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17922457
30Influenza A_Homo sapiens_hsa051641.16975788
31VEGF signaling pathway_Homo sapiens_hsa043701.16353305
32Fatty acid metabolism_Homo sapiens_hsa012121.15361680
33Glioma_Homo sapiens_hsa052141.14393940
34Proteoglycans in cancer_Homo sapiens_hsa052051.13782857
35Notch signaling pathway_Homo sapiens_hsa043301.12262025
36Vibrio cholerae infection_Homo sapiens_hsa051101.09403017
37Hepatitis B_Homo sapiens_hsa051611.09372351
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09140368
39Caffeine metabolism_Homo sapiens_hsa002321.08965646
40Butanoate metabolism_Homo sapiens_hsa006501.08260542
41B cell receptor signaling pathway_Homo sapiens_hsa046621.07124321
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07047733
43Non-small cell lung cancer_Homo sapiens_hsa052231.06061613
44Fructose and mannose metabolism_Homo sapiens_hsa000511.05743678
45Osteoclast differentiation_Homo sapiens_hsa043801.05674069
46Focal adhesion_Homo sapiens_hsa045101.04171974
47Viral myocarditis_Homo sapiens_hsa054161.02180540
48Antigen processing and presentation_Homo sapiens_hsa046121.02083231
49Pancreatic cancer_Homo sapiens_hsa052121.01801214
50Rheumatoid arthritis_Homo sapiens_hsa053231.01696119
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01089492
52Acute myeloid leukemia_Homo sapiens_hsa052211.00763442
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99703650
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.98493012
55Legionellosis_Homo sapiens_hsa051340.98211950
56Allograft rejection_Homo sapiens_hsa053300.97636179
57* Amoebiasis_Homo sapiens_hsa051460.96856157
58Measles_Homo sapiens_hsa051620.95906188
59Tryptophan metabolism_Homo sapiens_hsa003800.94050339
60mTOR signaling pathway_Homo sapiens_hsa041500.93649944
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93071536
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92689018
63Fat digestion and absorption_Homo sapiens_hsa049750.92108590
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91030365
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90959312
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89139164
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88934559
68Graft-versus-host disease_Homo sapiens_hsa053320.88177722
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.86659680
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.86642495
71Herpes simplex infection_Homo sapiens_hsa051680.86271111
72Leishmaniasis_Homo sapiens_hsa051400.84881404
73* Endocytosis_Homo sapiens_hsa041440.84796301
74T cell receptor signaling pathway_Homo sapiens_hsa046600.83830760
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83363992
76Other glycan degradation_Homo sapiens_hsa005110.82809419
77Toxoplasmosis_Homo sapiens_hsa051450.82360552
78Biosynthesis of amino acids_Homo sapiens_hsa012300.82232927
79Histidine metabolism_Homo sapiens_hsa003400.81606053
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81251336
81Small cell lung cancer_Homo sapiens_hsa052220.81214000
82ECM-receptor interaction_Homo sapiens_hsa045120.80905597
83Autoimmune thyroid disease_Homo sapiens_hsa053200.80221749
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80113969
85Hematopoietic cell lineage_Homo sapiens_hsa046400.79645079
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77026017
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76558790
88Prolactin signaling pathway_Homo sapiens_hsa049170.76009065
89Carbon metabolism_Homo sapiens_hsa012000.75483809
90Thyroid cancer_Homo sapiens_hsa052160.75446218
91Shigellosis_Homo sapiens_hsa051310.74956061
92Malaria_Homo sapiens_hsa051440.74698164
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.73589078
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71947787
95Glycerolipid metabolism_Homo sapiens_hsa005610.71491610
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71417580
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70175725
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70079586
99Insulin resistance_Homo sapiens_hsa049310.69760906
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.69651504
101Lysine degradation_Homo sapiens_hsa003100.68435546
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68247559
103Endometrial cancer_Homo sapiens_hsa052130.67627819
104Steroid biosynthesis_Homo sapiens_hsa001000.66103042
105Pertussis_Homo sapiens_hsa051330.65010985
106African trypanosomiasis_Homo sapiens_hsa051430.65003980
107GnRH signaling pathway_Homo sapiens_hsa049120.64543984
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.64326996
109Prion diseases_Homo sapiens_hsa050200.62970195
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60821729
111Salmonella infection_Homo sapiens_hsa051320.60746216
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60183315
113Platelet activation_Homo sapiens_hsa046110.59975086
114beta-Alanine metabolism_Homo sapiens_hsa004100.58381465
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58165115
116Hepatitis C_Homo sapiens_hsa051600.58151108
117HTLV-I infection_Homo sapiens_hsa051660.57994215
118ErbB signaling pathway_Homo sapiens_hsa040120.57744035
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.57398313
120* Tuberculosis_Homo sapiens_hsa051520.57063296
121Apoptosis_Homo sapiens_hsa042100.57013372
122Sulfur metabolism_Homo sapiens_hsa009200.56663118
123Fatty acid biosynthesis_Homo sapiens_hsa000610.56617517
124MicroRNAs in cancer_Homo sapiens_hsa052060.55778846
125Sulfur relay system_Homo sapiens_hsa041220.54687405
126Peroxisome_Homo sapiens_hsa041460.54396162
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54205531
128Estrogen signaling pathway_Homo sapiens_hsa049150.53307159
129Propanoate metabolism_Homo sapiens_hsa006400.53078266
130HIF-1 signaling pathway_Homo sapiens_hsa040660.52630748
131Mineral absorption_Homo sapiens_hsa049780.52404150
132Pentose phosphate pathway_Homo sapiens_hsa000300.52069908
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50840915
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50662402
135Viral carcinogenesis_Homo sapiens_hsa052030.49437657
136Chemokine signaling pathway_Homo sapiens_hsa040620.49131196
137AMPK signaling pathway_Homo sapiens_hsa041520.48639604
138Sphingolipid metabolism_Homo sapiens_hsa006000.48335857
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48162832
140Asthma_Homo sapiens_hsa053100.47977344
141Insulin signaling pathway_Homo sapiens_hsa049100.47732618
142Prostate cancer_Homo sapiens_hsa052150.46811568
143Epstein-Barr virus infection_Homo sapiens_hsa051690.44571002

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