

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | purine deoxyribonucleotide catabolic process (GO:0009155) | 5.14927302 |
| 2 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 5.14583716 |
| 3 | respiratory chain complex IV assembly (GO:0008535) | 5.14332498 |
| 4 | response to oxygen radical (GO:0000305) | 4.68060651 |
| 5 | nucleobase biosynthetic process (GO:0046112) | 4.56739052 |
| 6 | purine nucleobase biosynthetic process (GO:0009113) | 4.49867377 |
| 7 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.44448935 |
| 8 | GMP metabolic process (GO:0046037) | 4.36542281 |
| 9 | protein complex biogenesis (GO:0070271) | 4.31802471 |
| 10 | deoxyribonucleotide catabolic process (GO:0009264) | 4.30428449 |
| 11 | negative regulation of phosphoprotein phosphatase activity (GO:0032515) | 4.28849282 |
| 12 | cytochrome complex assembly (GO:0017004) | 4.27136075 |
| 13 | adenosine metabolic process (GO:0046085) | 4.25449694 |
| 14 | response to folic acid (GO:0051593) | 4.14358922 |
| 15 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.12148776 |
| 16 | NADH dehydrogenase complex assembly (GO:0010257) | 4.12148776 |
| 17 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.12148776 |
| 18 | DNA strand elongation (GO:0022616) | 4.05802446 |
| 19 | deoxyribose phosphate catabolic process (GO:0046386) | 4.04862053 |
| 20 | proteasome assembly (GO:0043248) | 4.00220143 |
| 21 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.97338968 |
| 22 | establishment of viral latency (GO:0019043) | 3.87787972 |
| 23 | base-excision repair, AP site formation (GO:0006285) | 3.79494907 |
| 24 | removal of superoxide radicals (GO:0019430) | 3.78936761 |
| 25 | cellular response to superoxide (GO:0071451) | 3.78936761 |
| 26 | cellular response to oxygen radical (GO:0071450) | 3.78936761 |
| 27 | response to superoxide (GO:0000303) | 3.70818910 |
| 28 | DNA integration (GO:0015074) | 3.68091226 |
| 29 | mannosylation (GO:0097502) | 3.67842428 |
| 30 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.67691812 |
| 31 | adaptation of signaling pathway (GO:0023058) | 3.64905526 |
| 32 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.64323399 |
| 33 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.60847807 |
| 34 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.60016388 |
| 35 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.45741993 |
| 36 | positive regulation of protein homooligomerization (GO:0032464) | 3.37145312 |
| 37 | purine-containing compound salvage (GO:0043101) | 3.35914225 |
| 38 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.31572263 |
| 39 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.27430052 |
| 40 | purine deoxyribonucleotide metabolic process (GO:0009151) | 3.27422228 |
| 41 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.27085363 |
| 42 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.26933118 |
| 43 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.26933118 |
| 44 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.26933118 |
| 45 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.24409856 |
| 46 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.24409856 |
| 47 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.21981626 |
| 48 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.21981626 |
| 49 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.21298250 |
| 50 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.21298250 |
| 51 | telomere maintenance via recombination (GO:0000722) | 3.18686725 |
| 52 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.18368294 |
| 53 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.18368294 |
| 54 | negative regulation of ligase activity (GO:0051352) | 3.17857376 |
| 55 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.17857376 |
| 56 | negative regulation of multicellular organism growth (GO:0040015) | 3.12679913 |
| 57 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.12008358 |
| 58 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.11981069 |
| 59 | cellular ketone body metabolic process (GO:0046950) | 3.09739412 |
| 60 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.08428807 |
| 61 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.07708107 |
| 62 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.01256093 |
| 63 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.01256093 |
| 64 | deoxyribonucleotide metabolic process (GO:0009262) | 3.01093846 |
| 65 | flavonoid metabolic process (GO:0009812) | 2.96959419 |
| 66 | regulation of female receptivity (GO:0045924) | 2.96785637 |
| 67 | GPI anchor biosynthetic process (GO:0006506) | 2.96201421 |
| 68 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.94798124 |
| 69 | translesion synthesis (GO:0019985) | 2.94446910 |
| 70 | GPI anchor metabolic process (GO:0006505) | 2.94216332 |
| 71 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.94166369 |
| 72 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.94162082 |
| 73 | oxidative demethylation (GO:0070989) | 2.92407386 |
| 74 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.90999058 |
| 75 | respiratory electron transport chain (GO:0022904) | 2.90312502 |
| 76 | deoxyribose phosphate metabolic process (GO:0019692) | 2.90288061 |
| 77 | estrogen biosynthetic process (GO:0006703) | 2.89678828 |
| 78 | meiotic chromosome segregation (GO:0045132) | 2.89548048 |
| 79 | mismatch repair (GO:0006298) | 2.88724393 |
| 80 | phosphatidylglycerol biosynthetic process (GO:0006655) | 2.87779941 |
| 81 | non-recombinational repair (GO:0000726) | 2.87040942 |
| 82 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.87040942 |
| 83 | mitotic recombination (GO:0006312) | 2.86100496 |
| 84 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.86007846 |
| 85 | DNA deamination (GO:0045006) | 2.85205811 |
| 86 | DNA replication initiation (GO:0006270) | 2.84453480 |
| 87 | protein import into peroxisome matrix (GO:0016558) | 2.81734740 |
| 88 | DNA ligation (GO:0006266) | 2.81231500 |
| 89 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 2.80987273 |
| 90 | IMP biosynthetic process (GO:0006188) | 2.80829993 |
| 91 | electron transport chain (GO:0022900) | 2.80717937 |
| 92 | postreplication repair (GO:0006301) | 2.79006346 |
| 93 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.78942073 |
| 94 | ATP synthesis coupled proton transport (GO:0015986) | 2.78942073 |
| 95 | quinone biosynthetic process (GO:1901663) | 2.78040880 |
| 96 | chaperone-mediated protein transport (GO:0072321) | 2.77781359 |
| 97 | purine nucleotide salvage (GO:0032261) | 2.76106545 |
| 98 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.75391768 |
| 99 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.71594543 |
| 100 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.70528756 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.86222120 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.75897341 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.31051769 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.19532185 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.97432533 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.79513246 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.62813372 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.60802045 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.56831884 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.55722564 |
| 11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.49367840 |
| 12 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.41471221 |
| 13 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.34773150 |
| 14 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.34537996 |
| 15 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.28254209 |
| 16 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.21008529 |
| 17 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.19943948 |
| 18 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.18646817 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.12423344 |
| 20 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.08463080 |
| 21 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.00421345 |
| 22 | GATA1_22025678_ChIP-Seq_K562_Human | 2.00128758 |
| 23 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.0853559 |
| 24 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.91677060 |
| 25 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.85254611 |
| 26 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.84706438 |
| 27 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.83011176 |
| 28 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.76659761 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.75097351 |
| 30 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.75003517 |
| 31 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.74052497 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.56063623 |
| 33 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.55907156 |
| 34 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.55812687 |
| 35 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.54208685 |
| 36 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.51739110 |
| 37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.49651345 |
| 38 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.49601973 |
| 39 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.49558502 |
| 40 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.47478901 |
| 41 | EWS_26573619_Chip-Seq_HEK293_Human | 1.47439922 |
| 42 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.46927297 |
| 43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.45936125 |
| 44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.44745264 |
| 45 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.42466005 |
| 46 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.40278769 |
| 47 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.39824159 |
| 48 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.37534738 |
| 49 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32274478 |
| 50 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.32201603 |
| 51 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.29979253 |
| 52 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.29416475 |
| 53 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.29293237 |
| 54 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.28689140 |
| 55 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.23318875 |
| 56 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.20453106 |
| 57 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.19748773 |
| 58 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.19042617 |
| 59 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.18962651 |
| 60 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.14534645 |
| 61 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.13624935 |
| 62 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.08996907 |
| 63 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.06526120 |
| 64 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.05849996 |
| 65 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.04755384 |
| 66 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.04755384 |
| 67 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.01566369 |
| 68 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.01312161 |
| 69 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.01312161 |
| 70 | NCOR_22424771_ChIP-Seq_293T_Human | 1.00288018 |
| 71 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.99567943 |
| 72 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.98756192 |
| 73 | FUS_26573619_Chip-Seq_HEK293_Human | 0.98599483 |
| 74 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.98388219 |
| 75 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97033764 |
| 76 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.96625601 |
| 77 | AR_20517297_ChIP-Seq_VCAP_Human | 0.95375284 |
| 78 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.93882304 |
| 79 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.93697712 |
| 80 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.92792047 |
| 81 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.91893592 |
| 82 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91882758 |
| 83 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91113267 |
| 84 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.90946134 |
| 85 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.90346641 |
| 86 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.89416846 |
| 87 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.89247188 |
| 88 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.88776733 |
| 89 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.88694356 |
| 90 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.88636235 |
| 91 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.85818908 |
| 92 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85424105 |
| 93 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.81127530 |
| 94 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.79894943 |
| 95 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.79817840 |
| 96 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.79135450 |
| 97 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.78187142 |
| 98 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.77334677 |
| 99 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.76450610 |
| 100 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.74896441 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002876_abnormal_thyroid_physiology | 3.94393807 |
| 2 | MP0009780_abnormal_chondrocyte_physiolo | 3.78069695 |
| 3 | MP0008058_abnormal_DNA_repair | 3.68133625 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.53531938 |
| 5 | MP0003786_premature_aging | 3.35212736 |
| 6 | MP0005646_abnormal_pituitary_gland | 3.01637133 |
| 7 | MP0002163_abnormal_gland_morphology | 2.98425064 |
| 8 | MP0009697_abnormal_copulation | 2.93072106 |
| 9 | MP0000569_abnormal_digit_pigmentation | 2.84224705 |
| 10 | MP0005377_hearing/vestibular/ear_phenot | 2.77978201 |
| 11 | MP0003878_abnormal_ear_physiology | 2.77978201 |
| 12 | MP0008995_early_reproductive_senescence | 2.69778096 |
| 13 | MP0006035_abnormal_mitochondrial_morpho | 2.43185897 |
| 14 | MP0002837_dystrophic_cardiac_calcinosis | 2.23918473 |
| 15 | MP0005379_endocrine/exocrine_gland_phen | 2.08185691 |
| 16 | MP0005551_abnormal_eye_electrophysiolog | 1.94884554 |
| 17 | MP0004957_abnormal_blastocyst_morpholog | 1.89859542 |
| 18 | MP0003111_abnormal_nucleus_morphology | 1.80586300 |
| 19 | MP0006036_abnormal_mitochondrial_physio | 1.79150935 |
| 20 | MP0001968_abnormal_touch/_nociception | 1.78239062 |
| 21 | MP0002332_abnormal_exercise_endurance | 1.77145270 |
| 22 | MP0001485_abnormal_pinna_reflex | 1.74315283 |
| 23 | MP0003195_calcinosis | 1.69578834 |
| 24 | MP0003567_abnormal_fetal_cardiomyocyte | 1.68376448 |
| 25 | MP0005266_abnormal_metabolism | 1.63601403 |
| 26 | MP0001661_extended_life_span | 1.58045026 |
| 27 | MP0006072_abnormal_retinal_apoptosis | 1.53204387 |
| 28 | MP0004043_abnormal_pH_regulation | 1.45173359 |
| 29 | MP0001346_abnormal_lacrimal_gland | 1.43754686 |
| 30 | MP0003693_abnormal_embryo_hatching | 1.43089372 |
| 31 | MP0003806_abnormal_nucleotide_metabolis | 1.42900975 |
| 32 | MP0003646_muscle_fatigue | 1.40420773 |
| 33 | MP0008875_abnormal_xenobiotic_pharmacok | 1.38078604 |
| 34 | MP0003011_delayed_dark_adaptation | 1.36755338 |
| 35 | MP0006276_abnormal_autonomic_nervous | 1.35929307 |
| 36 | MP0003077_abnormal_cell_cycle | 1.31971236 |
| 37 | MP0009278_abnormal_bone_marrow | 1.31083970 |
| 38 | MP0009046_muscle_twitch | 1.21268905 |
| 39 | MP0001905_abnormal_dopamine_level | 1.17078017 |
| 40 | MP0003763_abnormal_thymus_physiology | 1.15710060 |
| 41 | MP0005167_abnormal_blood-brain_barrier | 1.15058845 |
| 42 | MP0004142_abnormal_muscle_tone | 1.14080558 |
| 43 | MP0001929_abnormal_gametogenesis | 1.13651242 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.11202491 |
| 45 | MP0005330_cardiomyopathy | 1.11035864 |
| 46 | MP0002102_abnormal_ear_morphology | 1.10885308 |
| 47 | MP0000358_abnormal_cell_content/ | 1.10736271 |
| 48 | MP0002210_abnormal_sex_determination | 1.06441746 |
| 49 | MP0002396_abnormal_hematopoietic_system | 1.04971208 |
| 50 | MP0003191_abnormal_cellular_cholesterol | 1.03510844 |
| 51 | MP0001764_abnormal_homeostasis | 1.03506550 |
| 52 | MP0003638_abnormal_response/metabolism_ | 1.01827028 |
| 53 | MP0005671_abnormal_response_to | 1.01400803 |
| 54 | MP0001879_abnormal_lymphatic_vessel | 1.01313082 |
| 55 | MP0000372_irregular_coat_pigmentation | 1.01038255 |
| 56 | MP0002095_abnormal_skin_pigmentation | 1.00099469 |
| 57 | MP0005075_abnormal_melanosome_morpholog | 0.99651243 |
| 58 | MP0002019_abnormal_tumor_incidence | 0.96589088 |
| 59 | MP0001119_abnormal_female_reproductive | 0.95731783 |
| 60 | MP0000003_abnormal_adipose_tissue | 0.94669184 |
| 61 | MP0003252_abnormal_bile_duct | 0.92812184 |
| 62 | MP0000015_abnormal_ear_pigmentation | 0.92108061 |
| 63 | MP0008007_abnormal_cellular_replicative | 0.92103290 |
| 64 | MP0000749_muscle_degeneration | 0.91817119 |
| 65 | MP0005332_abnormal_amino_acid | 0.91621874 |
| 66 | MP0000371_diluted_coat_color | 0.87475858 |
| 67 | MP0005385_cardiovascular_system_phenoty | 0.87122611 |
| 68 | MP0001544_abnormal_cardiovascular_syste | 0.87122611 |
| 69 | MP0005319_abnormal_enzyme/_coenzyme | 0.86797284 |
| 70 | MP0004215_abnormal_myocardial_fiber | 0.86570672 |
| 71 | MP0008873_increased_physiological_sensi | 0.85363495 |
| 72 | MP0002736_abnormal_nociception_after | 0.83559223 |
| 73 | MP0008932_abnormal_embryonic_tissue | 0.83185890 |
| 74 | MP0004147_increased_porphyrin_level | 0.82987523 |
| 75 | MP0005365_abnormal_bile_salt | 0.82677501 |
| 76 | MP0008877_abnormal_DNA_methylation | 0.81958139 |
| 77 | MP0000653_abnormal_sex_gland | 0.81818282 |
| 78 | MP0005464_abnormal_platelet_physiology | 0.80976581 |
| 79 | MP0005253_abnormal_eye_physiology | 0.78696075 |
| 80 | MP0005448_abnormal_energy_balance | 0.78380488 |
| 81 | MP0004185_abnormal_adipocyte_glucose | 0.77175112 |
| 82 | MP0001145_abnormal_male_reproductive | 0.75810301 |
| 83 | MP0002090_abnormal_vision | 0.75065263 |
| 84 | MP0005647_abnormal_sex_gland | 0.75061407 |
| 85 | MP0003879_abnormal_hair_cell | 0.73564937 |
| 86 | MP0001963_abnormal_hearing_physiology | 0.73248730 |
| 87 | MP0002693_abnormal_pancreas_physiology | 0.72350615 |
| 88 | MP0010368_abnormal_lymphatic_system | 0.71358911 |
| 89 | MP0002229_neurodegeneration | 0.70011773 |
| 90 | MP0003890_abnormal_embryonic-extraembry | 0.69379154 |
| 91 | MP0005376_homeostasis/metabolism_phenot | 0.69222370 |
| 92 | MP0003698_abnormal_male_reproductive | 0.68654673 |
| 93 | MP0004145_abnormal_muscle_electrophysio | 0.66590296 |
| 94 | MP0002067_abnormal_sensory_capabilities | 0.65451170 |
| 95 | MP0000427_abnormal_hair_cycle | 0.64462900 |
| 96 | MP0002160_abnormal_reproductive_system | 0.64304544 |
| 97 | MP0005670_abnormal_white_adipose | 0.61140057 |
| 98 | MP0005535_abnormal_body_temperature | 0.59920518 |
| 99 | MP0008872_abnormal_physiological_respon | 0.59090425 |
| 100 | MP0009763_increased_sensitivity_to | 0.56866931 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mitochondrial inheritance (HP:0001427) | 4.47700020 |
| 2 | Lipid accumulation in hepatocytes (HP:0006561) | 4.45474485 |
| 3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.26873889 |
| 4 | Chromsome breakage (HP:0040012) | 3.86611198 |
| 5 | Type I transferrin isoform profile (HP:0003642) | 3.82627818 |
| 6 | Hepatocellular necrosis (HP:0001404) | 3.71361384 |
| 7 | Abnormality of the ileum (HP:0001549) | 3.62759222 |
| 8 | Duplicated collecting system (HP:0000081) | 3.50943756 |
| 9 | Acute necrotizing encephalopathy (HP:0006965) | 3.45213693 |
| 10 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.41713656 |
| 11 | Increased CSF lactate (HP:0002490) | 3.41076060 |
| 12 | Severe visual impairment (HP:0001141) | 3.39958511 |
| 13 | Renal cortical cysts (HP:0000803) | 3.36928610 |
| 14 | Hepatic necrosis (HP:0002605) | 3.33323894 |
| 15 | Abnormality of the renal collecting system (HP:0004742) | 3.32536947 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.30166234 |
| 17 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.20009724 |
| 18 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.14264057 |
| 19 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.07654826 |
| 20 | Abnormality of chromosome stability (HP:0003220) | 2.99772055 |
| 21 | 3-Methylglutaconic aciduria (HP:0003535) | 2.98794463 |
| 22 | Meckel diverticulum (HP:0002245) | 2.96982343 |
| 23 | Large for gestational age (HP:0001520) | 2.92980158 |
| 24 | Increased muscle lipid content (HP:0009058) | 2.91275405 |
| 25 | Intestinal atresia (HP:0011100) | 2.88567474 |
| 26 | Acute encephalopathy (HP:0006846) | 2.87072641 |
| 27 | Abnormality of the preputium (HP:0100587) | 2.84809807 |
| 28 | Ureteral duplication (HP:0000073) | 2.84697601 |
| 29 | Autoimmune hemolytic anemia (HP:0001890) | 2.83369231 |
| 30 | Renal Fanconi syndrome (HP:0001994) | 2.82064220 |
| 31 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.78674818 |
| 32 | Abnormality of DNA repair (HP:0003254) | 2.77137514 |
| 33 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.74448104 |
| 34 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.74448104 |
| 35 | Abnormal protein glycosylation (HP:0012346) | 2.74448104 |
| 36 | Abnormal glycosylation (HP:0012345) | 2.74448104 |
| 37 | Reticulocytopenia (HP:0001896) | 2.66076502 |
| 38 | Progressive macrocephaly (HP:0004481) | 2.61812964 |
| 39 | Reduced antithrombin III activity (HP:0001976) | 2.60855562 |
| 40 | Progressive microcephaly (HP:0000253) | 2.56914628 |
| 41 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.54835480 |
| 42 | Polydipsia (HP:0001959) | 2.46467487 |
| 43 | Abnormal drinking behavior (HP:0030082) | 2.46467487 |
| 44 | Exertional dyspnea (HP:0002875) | 2.43925129 |
| 45 | Thyroid-stimulating hormone excess (HP:0002925) | 2.43513434 |
| 46 | Increased circulating renin level (HP:0000848) | 2.42583444 |
| 47 | Clubbing of toes (HP:0100760) | 2.41471137 |
| 48 | Colon cancer (HP:0003003) | 2.34243499 |
| 49 | Attenuation of retinal blood vessels (HP:0007843) | 2.32133829 |
| 50 | Hypomagnesemia (HP:0002917) | 2.31914863 |
| 51 | Increased intramyocellular lipid droplets (HP:0012240) | 2.30669661 |
| 52 | Cerebral edema (HP:0002181) | 2.30462475 |
| 53 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.28384134 |
| 54 | Autoimmune thrombocytopenia (HP:0001973) | 2.28038741 |
| 55 | Duodenal stenosis (HP:0100867) | 2.24158975 |
| 56 | Small intestinal stenosis (HP:0012848) | 2.24158975 |
| 57 | Respiratory failure (HP:0002878) | 2.23209022 |
| 58 | Ependymoma (HP:0002888) | 2.20214871 |
| 59 | Abnormality of the renal cortex (HP:0011035) | 2.17688411 |
| 60 | Cleft eyelid (HP:0000625) | 2.15738999 |
| 61 | Abnormality of methionine metabolism (HP:0010901) | 2.13267356 |
| 62 | Lactic acidosis (HP:0003128) | 2.12679469 |
| 63 | Abnormality of cochlea (HP:0000375) | 2.12502768 |
| 64 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.11234245 |
| 65 | Abnormality of urine glucose concentration (HP:0011016) | 2.10862295 |
| 66 | Glycosuria (HP:0003076) | 2.10862295 |
| 67 | Increased serum lactate (HP:0002151) | 2.06808546 |
| 68 | Respiratory difficulties (HP:0002880) | 2.05378805 |
| 69 | Volvulus (HP:0002580) | 2.04014836 |
| 70 | Rough bone trabeculation (HP:0100670) | 2.01184814 |
| 71 | Glioma (HP:0009733) | 1.97755415 |
| 72 | Hypokalemic alkalosis (HP:0001949) | 1.97706467 |
| 73 | Pigmentary retinal degeneration (HP:0001146) | 1.97330792 |
| 74 | Nephronophthisis (HP:0000090) | 1.96583044 |
| 75 | Metabolic alkalosis (HP:0200114) | 1.94252560 |
| 76 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.94240332 |
| 77 | Dicarboxylic aciduria (HP:0003215) | 1.94240332 |
| 78 | Abnormality of magnesium homeostasis (HP:0004921) | 1.93645709 |
| 79 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.90958119 |
| 80 | Abnormality of glycolipid metabolism (HP:0010969) | 1.90196898 |
| 81 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.90196898 |
| 82 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.90196898 |
| 83 | Hyperthyroidism (HP:0000836) | 1.89893292 |
| 84 | Severe global developmental delay (HP:0011344) | 1.89275445 |
| 85 | Cerebral hemorrhage (HP:0001342) | 1.88861402 |
| 86 | Hypoalbuminemia (HP:0003073) | 1.87734518 |
| 87 | Abnormal albumin level (HP:0012116) | 1.87734518 |
| 88 | Abnormality of the duodenum (HP:0002246) | 1.85343933 |
| 89 | Horseshoe kidney (HP:0000085) | 1.85206713 |
| 90 | Polyuria (HP:0000103) | 1.84145393 |
| 91 | Tetany (HP:0001281) | 1.82127858 |
| 92 | Neutropenia (HP:0001875) | 1.82103462 |
| 93 | Optic disc pallor (HP:0000543) | 1.80209113 |
| 94 | Pancytopenia (HP:0001876) | 1.79562287 |
| 95 | Absent thumb (HP:0009777) | 1.78729891 |
| 96 | Gastrointestinal atresia (HP:0002589) | 1.76294223 |
| 97 | Bone marrow hypocellularity (HP:0005528) | 1.75702726 |
| 98 | Tinnitus (HP:0000360) | 1.75236960 |
| 99 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.74743112 |
| 100 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.73982007 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 5.40519507 |
| 2 | BCKDK | 3.77447580 |
| 3 | MAP3K12 | 3.62021659 |
| 4 | BUB1 | 3.58781105 |
| 5 | VRK2 | 3.30523730 |
| 6 | RPS6KA4 | 2.64600495 |
| 7 | BMPR1B | 2.43624723 |
| 8 | ZAK | 2.34668083 |
| 9 | BCR | 2.15770974 |
| 10 | KDR | 1.95769556 |
| 11 | MAP4K2 | 1.95622117 |
| 12 | TIE1 | 1.83575891 |
| 13 | TEC | 1.77461812 |
| 14 | TGFBR2 | 1.71050239 |
| 15 | FRK | 1.64715150 |
| 16 | NEK1 | 1.61989582 |
| 17 | GRK7 | 1.61102939 |
| 18 | CDC7 | 1.55235223 |
| 19 | TNK2 | 1.53634817 |
| 20 | WNK3 | 1.46420267 |
| 21 | PASK | 1.40385823 |
| 22 | CSNK1A1L | 1.35369474 |
| 23 | PBK | 1.33814908 |
| 24 | CSNK1G1 | 1.33046681 |
| 25 | TRIM28 | 1.29862346 |
| 26 | MYLK | 1.26143035 |
| 27 | VRK1 | 1.25306347 |
| 28 | RPS6KA5 | 1.21527094 |
| 29 | CDK19 | 1.20832528 |
| 30 | EIF2AK3 | 1.20230669 |
| 31 | ATR | 1.13034609 |
| 32 | CSNK1G3 | 1.10344629 |
| 33 | TESK2 | 1.08860747 |
| 34 | CAMKK2 | 1.08163009 |
| 35 | STK10 | 1.02825287 |
| 36 | CDK3 | 0.96998812 |
| 37 | EIF2AK1 | 0.95041035 |
| 38 | TSSK6 | 0.92644998 |
| 39 | CSNK1G2 | 0.91021097 |
| 40 | PLK4 | 0.89450979 |
| 41 | DAPK1 | 0.87630044 |
| 42 | GRK6 | 0.87243594 |
| 43 | EIF2AK2 | 0.85716189 |
| 44 | GRK5 | 0.84091151 |
| 45 | CDK8 | 0.81928920 |
| 46 | BLK | 0.80834195 |
| 47 | BTK | 0.78537115 |
| 48 | NUAK1 | 0.78498074 |
| 49 | SYK | 0.78290181 |
| 50 | WEE1 | 0.76079912 |
| 51 | SCYL2 | 0.74466226 |
| 52 | TXK | 0.74168915 |
| 53 | INSRR | 0.73178867 |
| 54 | STK38L | 0.72854845 |
| 55 | ITK | 0.71715151 |
| 56 | CAMK1D | 0.71618888 |
| 57 | CHEK2 | 0.71460809 |
| 58 | MOS | 0.69444031 |
| 59 | ERBB3 | 0.68266454 |
| 60 | NME1 | 0.66299538 |
| 61 | OBSCN | 0.66008227 |
| 62 | AURKB | 0.65642241 |
| 63 | CAMKK1 | 0.64795890 |
| 64 | STK16 | 0.63838601 |
| 65 | IKBKE | 0.63807315 |
| 66 | ZAP70 | 0.63697576 |
| 67 | CDK12 | 0.62516000 |
| 68 | TGFBR1 | 0.61439882 |
| 69 | MAP2K6 | 0.61142216 |
| 70 | CCNB1 | 0.60640778 |
| 71 | STK4 | 0.59048965 |
| 72 | CAMK1 | 0.57655516 |
| 73 | GRK1 | 0.55018051 |
| 74 | PAK3 | 0.54243404 |
| 75 | CHEK1 | 0.52977913 |
| 76 | CLK1 | 0.52011604 |
| 77 | MAPK11 | 0.50553036 |
| 78 | HCK | 0.50399318 |
| 79 | OXSR1 | 0.50273019 |
| 80 | CDK4 | 0.49275311 |
| 81 | AURKA | 0.47592877 |
| 82 | TBK1 | 0.47507513 |
| 83 | CDK7 | 0.46962520 |
| 84 | FLT3 | 0.42971549 |
| 85 | NLK | 0.41172537 |
| 86 | TESK1 | 0.40920486 |
| 87 | SGK2 | 0.40657308 |
| 88 | PRKCG | 0.40493722 |
| 89 | LYN | 0.39210963 |
| 90 | CAMK4 | 0.36357495 |
| 91 | ATM | 0.35578455 |
| 92 | CSNK2A2 | 0.35337542 |
| 93 | ADRBK1 | 0.34428206 |
| 94 | SRPK1 | 0.34079751 |
| 95 | TTK | 0.33184747 |
| 96 | MAPK13 | 0.33045883 |
| 97 | PRKCD | 0.32959355 |
| 98 | PLK1 | 0.32822210 |
| 99 | ABL2 | 0.31575654 |
| 100 | MELK | 0.31476514 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.48810174 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.43124819 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.82540006 |
| 4 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 3.49986437 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 3.39652488 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.12230898 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.02115040 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.85988052 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.72165344 |
| 10 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.25686015 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.12644017 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.06493131 |
| 13 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.00574837 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 1.92949389 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 1.86027699 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.82111409 |
| 17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.79348416 |
| 18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.60909366 |
| 19 | Peroxisome_Homo sapiens_hsa04146 | 1.59421018 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.45647322 |
| 21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.38570609 |
| 22 | Alzheimers disease_Homo sapiens_hsa05010 | 1.38179154 |
| 23 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.32932125 |
| 24 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.32711740 |
| 25 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.31967583 |
| 26 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.30995961 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.26779198 |
| 28 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.21437902 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.21405357 |
| 30 | Phototransduction_Homo sapiens_hsa04744 | 1.20787895 |
| 31 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.17670646 |
| 32 | Retinol metabolism_Homo sapiens_hsa00830 | 1.16243698 |
| 33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.12562642 |
| 34 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.11997940 |
| 35 | Protein export_Homo sapiens_hsa03060 | 1.11913419 |
| 36 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.11834797 |
| 37 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.10896109 |
| 38 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.07796334 |
| 39 | RNA transport_Homo sapiens_hsa03013 | 1.05564756 |
| 40 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.04307572 |
| 41 | Cell cycle_Homo sapiens_hsa04110 | 1.03992768 |
| 42 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.95011041 |
| 43 | RNA degradation_Homo sapiens_hsa03018 | 0.93930626 |
| 44 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.89442984 |
| 45 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.89351020 |
| 46 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.85083070 |
| 47 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.83159973 |
| 48 | Basal transcription factors_Homo sapiens_hsa03022 | 0.78277046 |
| 49 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.76655384 |
| 50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.75960139 |
| 51 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.75094503 |
| 52 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.73425769 |
| 53 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.72828975 |
| 54 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.72484986 |
| 55 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.70927153 |
| 56 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68411770 |
| 57 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.63197840 |
| 58 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.62050798 |
| 59 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62013262 |
| 60 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.60783377 |
| 61 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.59807224 |
| 62 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.56721130 |
| 63 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.56469774 |
| 64 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.55525386 |
| 65 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.54577836 |
| 66 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.53005769 |
| 67 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50225896 |
| 68 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.49686057 |
| 69 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.49079756 |
| 70 | Olfactory transduction_Homo sapiens_hsa04740 | 0.47919539 |
| 71 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.44331988 |
| 72 | Taste transduction_Homo sapiens_hsa04742 | 0.42586148 |
| 73 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.42163080 |
| 74 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.41943000 |
| 75 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.41797863 |
| 76 | Legionellosis_Homo sapiens_hsa05134 | 0.41659173 |
| 77 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41101375 |
| 78 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.40854779 |
| 79 | Lysine degradation_Homo sapiens_hsa00310 | 0.39450779 |
| 80 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.39247882 |
| 81 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.38356094 |
| 82 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.35850252 |
| 83 | ABC transporters_Homo sapiens_hsa02010 | 0.34968351 |
| 84 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.32598577 |
| 85 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.32494823 |
| 86 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.28776599 |
| 87 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.26594177 |
| 88 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.22910517 |
| 89 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.22714574 |
| 90 | Nicotine addiction_Homo sapiens_hsa05033 | 0.21345011 |
| 91 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.20781291 |
| 92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.19490525 |
| 93 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.17710763 |
| 94 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.16326783 |
| 95 | Allograft rejection_Homo sapiens_hsa05330 | 0.14957444 |
| 96 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.14738653 |
| 97 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.14571434 |
| 98 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.14230125 |
| 99 | Shigellosis_Homo sapiens_hsa05131 | 0.14065008 |
| 100 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.13857077 |

