RAB6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.56700267
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.37068861
3locomotory exploration behavior (GO:0035641)5.89503621
4synaptic vesicle exocytosis (GO:0016079)5.84036122
5glutamate secretion (GO:0014047)5.78717967
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75580456
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.64713182
8vocalization behavior (GO:0071625)5.49361848
9regulation of synaptic vesicle exocytosis (GO:2000300)5.31003849
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23229081
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.20230264
12regulation of glutamate receptor signaling pathway (GO:1900449)4.89338368
13protein localization to synapse (GO:0035418)4.86583560
14regulation of synaptic vesicle transport (GO:1902803)4.70192255
15exploration behavior (GO:0035640)4.67653187
16neurotransmitter secretion (GO:0007269)4.63986591
17layer formation in cerebral cortex (GO:0021819)4.63726146
18neuron cell-cell adhesion (GO:0007158)4.62291149
19cerebellar granule cell differentiation (GO:0021707)4.54866300
20neuronal action potential propagation (GO:0019227)4.49785440
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49207417
22regulation of neuronal synaptic plasticity (GO:0048168)4.48797716
23regulation of synapse structural plasticity (GO:0051823)4.43305815
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.42932938
25L-amino acid import (GO:0043092)4.34924992
26proline transport (GO:0015824)4.24121108
27dendritic spine morphogenesis (GO:0060997)4.11928241
28gamma-aminobutyric acid transport (GO:0015812)4.07279709
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05944849
30synaptic transmission, glutamatergic (GO:0035249)4.05232215
31neurotransmitter-gated ion channel clustering (GO:0072578)3.97270435
32potassium ion homeostasis (GO:0055075)3.94015406
33central nervous system myelination (GO:0022010)3.92887135
34axon ensheathment in central nervous system (GO:0032291)3.92887135
35glutamate receptor signaling pathway (GO:0007215)3.89718892
36neuron-neuron synaptic transmission (GO:0007270)3.88223302
37amino acid import (GO:0043090)3.87846403
38cellular potassium ion homeostasis (GO:0030007)3.85929074
39positive regulation of membrane potential (GO:0045838)3.79063039
40long-term memory (GO:0007616)3.77493282
41regulation of voltage-gated calcium channel activity (GO:1901385)3.75411341
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.74741889
43neurotransmitter transport (GO:0006836)3.74363648
44regulation of synapse maturation (GO:0090128)3.71812222
45activation of protein kinase A activity (GO:0034199)3.71783425
46potassium ion import (GO:0010107)3.71580880
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66681684
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.60496856
49regulation of synaptic plasticity (GO:0048167)3.60063430
50sodium ion export (GO:0071436)3.59905631
51negative regulation of dendrite morphogenesis (GO:0050774)3.57471485
52regulation of postsynaptic membrane potential (GO:0060078)3.57361156
53regulation of neurotransmitter secretion (GO:0046928)3.54630068
54neuron recognition (GO:0008038)3.53315806
55neuromuscular process controlling balance (GO:0050885)3.53083679
56regulation of dendritic spine morphogenesis (GO:0061001)3.49857665
57positive regulation of synapse maturation (GO:0090129)3.48642982
58regulation of neurotransmitter levels (GO:0001505)3.47421262
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46804543
60synaptic vesicle endocytosis (GO:0048488)3.44517918
61presynaptic membrane organization (GO:0097090)3.42763593
62establishment of mitochondrion localization (GO:0051654)3.42115747
63cellular sodium ion homeostasis (GO:0006883)3.38793430
64cerebellar Purkinje cell differentiation (GO:0021702)3.38775915
65dendrite morphogenesis (GO:0048813)3.37336657
66transmission of nerve impulse (GO:0019226)3.35289490
67neuromuscular synaptic transmission (GO:0007274)3.34693982
68long-term synaptic potentiation (GO:0060291)3.34034946
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33891740
70regulation of vesicle fusion (GO:0031338)3.33677460
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33185714
72auditory behavior (GO:0031223)3.30783510
73postsynaptic membrane organization (GO:0001941)3.29070857
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28043911
75regulation of neurotransmitter transport (GO:0051588)3.27606720
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27018911
77glycine transport (GO:0015816)3.26497284
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.25607568
79axonal fasciculation (GO:0007413)3.24597456
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22792765
81cell migration in hindbrain (GO:0021535)3.22531776
82prepulse inhibition (GO:0060134)3.22213830
83response to auditory stimulus (GO:0010996)3.22116170
84positive regulation of neurotransmitter secretion (GO:0001956)3.21820767
85neurotransmitter uptake (GO:0001504)3.21624398
86positive regulation of neurotransmitter transport (GO:0051590)3.21429719
87vesicle transport along microtubule (GO:0047496)3.21280510
88neuromuscular process controlling posture (GO:0050884)3.21047883
89gamma-aminobutyric acid signaling pathway (GO:0007214)3.14567761
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14252940
91membrane depolarization during action potential (GO:0086010)3.13921661
92membrane depolarization (GO:0051899)3.12874807
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12099772
94cell communication by electrical coupling (GO:0010644)3.08732552
95membrane hyperpolarization (GO:0060081)3.07084610
96innervation (GO:0060384)3.06884998
97synapse assembly (GO:0007416)3.05022057
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04718023
99organelle transport along microtubule (GO:0072384)3.02040035
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01812115
101learning (GO:0007612)3.01714808
102regulation of dendritic spine development (GO:0060998)3.01420962
103neuromuscular process (GO:0050905)3.01118586
104intraspecies interaction between organisms (GO:0051703)3.00733246
105social behavior (GO:0035176)3.00733246
106mitochondrion transport along microtubule (GO:0047497)2.99800611
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.99800611
108regulation of synaptic transmission (GO:0050804)2.99384464
109regulation of ARF protein signal transduction (GO:0032012)2.98786983
110positive regulation of synaptic transmission (GO:0050806)2.98330698
111acidic amino acid transport (GO:0015800)2.97485696
112synaptic transmission (GO:0007268)2.97189317
113neuronal ion channel clustering (GO:0045161)2.95597442
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94954114
115establishment of synaptic vesicle localization (GO:0097480)2.94790444
116negative regulation of microtubule polymerization (GO:0031115)2.92745984
117positive regulation of dendritic spine development (GO:0060999)2.92209462
118response to histamine (GO:0034776)2.92022839
119dendritic spine organization (GO:0097061)2.91381725
120presynaptic membrane assembly (GO:0097105)2.90627249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13678581
2GBX2_23144817_ChIP-Seq_PC3_Human3.34873928
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15575484
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09292470
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05506431
6REST_21632747_ChIP-Seq_MESCs_Mouse2.83475928
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74627293
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74627293
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.71236282
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67485754
11DROSHA_22980978_ChIP-Seq_HELA_Human2.60861961
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57589554
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56864098
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56159561
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.47795370
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46645115
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45996568
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.33630988
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30053978
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26429965
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.19577041
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.17874559
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09581720
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09475742
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04995122
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03357588
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99880441
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97973502
29AR_21572438_ChIP-Seq_LNCaP_Human1.97542411
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96292869
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83289423
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68258907
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.65092560
34TAF15_26573619_Chip-Seq_HEK293_Human1.62320548
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59424189
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56126787
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53244287
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37093001
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36758021
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34826219
41SOX2_21211035_ChIP-Seq_LN229_Gbm1.33383728
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.33123143
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31460319
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31189137
45ZNF274_21170338_ChIP-Seq_K562_Hela1.28596442
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.26193216
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24435822
48P300_19829295_ChIP-Seq_ESCs_Human1.24189726
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23845570
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21390795
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.21191055
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21071732
53KDM2B_26808549_Chip-Seq_K562_Human1.19735322
54* AR_19668381_ChIP-Seq_PC3_Human1.19601050
55AR_25329375_ChIP-Seq_VCAP_Human1.19149833
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18827030
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.17937843
58* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17668953
59* STAT3_23295773_ChIP-Seq_U87_Human1.16351913
60* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15311972
61* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13455078
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13300990
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.13277920
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12933926
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12389255
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11518894
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11124238
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10821569
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10351889
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09097266
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07043847
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06451293
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06163790
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.05918711
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.03528543
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03124491
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03052445
78AHR_22903824_ChIP-Seq_MCF-7_Human1.02655446
79TCF4_23295773_ChIP-Seq_U87_Human1.01692807
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01655582
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.00953355
82RNF2_27304074_Chip-Seq_NSC_Mouse0.99182247
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98060130
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97134089
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.96701913
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96682975
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95845300
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.95719354
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.94914987
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.94723984
91IGF1R_20145208_ChIP-Seq_DFB_Human0.94664390
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93740204
93* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92738409
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92493609
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92233914
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91683660
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.90201184
98RUNX2_22187159_ChIP-Seq_PCA_Human0.89412154
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88836546
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.88260503
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87640257
102DPY_21335234_ChIP-Seq_ESCs_Mouse0.87251931
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86890573
104RXR_22108803_ChIP-Seq_LS180_Human0.86346638
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86326441
106TP53_16413492_ChIP-PET_HCT116_Human0.86116819
107CTCF_27219007_Chip-Seq_Bcells_Human0.85500056
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84703088
109JUN_21703547_ChIP-Seq_K562_Human0.83612082
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83173357
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83094791
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82805075
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82805075
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81727029
115OCT4_19829295_ChIP-Seq_ESCs_Human0.80989695
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80381007
117RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77885298
118KLF4_19829295_ChIP-Seq_ESCs_Human0.76571563
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76297182
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75900975
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75555614
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74910902
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74059298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.80760119
2MP0003880_abnormal_central_pattern4.68198331
3MP0003635_abnormal_synaptic_transmissio4.25441974
4MP0004270_analgesia4.15894215
5MP0009745_abnormal_behavioral_response3.39109200
6MP0002063_abnormal_learning/memory/cond3.37383720
7MP0001968_abnormal_touch/_nociception3.30752119
8MP0002064_seizures3.18342540
9MP0009046_muscle_twitch3.12089390
10MP0005423_abnormal_somatic_nervous2.98206315
11MP0002734_abnormal_mechanical_nocicepti2.92644460
12MP0002822_catalepsy2.82608078
13MP0002572_abnormal_emotion/affect_behav2.79696223
14MP0002272_abnormal_nervous_system2.60626841
15MP0001486_abnormal_startle_reflex2.55198620
16MP0002735_abnormal_chemical_nociception2.55000182
17MP0002736_abnormal_nociception_after2.49239362
18MP0002733_abnormal_thermal_nociception2.32416290
19MP0001501_abnormal_sleep_pattern2.19941154
20MP0001970_abnormal_pain_threshold2.17366279
21MP0001440_abnormal_grooming_behavior2.08569146
22MP0004858_abnormal_nervous_system2.05651534
23MP0003329_amyloid_beta_deposits1.98668193
24MP0002067_abnormal_sensory_capabilities1.98133417
25MP0009780_abnormal_chondrocyte_physiolo1.95925256
26MP0004811_abnormal_neuron_physiology1.94216382
27MP0008569_lethality_at_weaning1.90366921
28MP0002184_abnormal_innervation1.89204866
29MP0000778_abnormal_nervous_system1.86438950
30MP0006276_abnormal_autonomic_nervous1.82870898
31MP0002909_abnormal_adrenal_gland1.78493654
32MP0002557_abnormal_social/conspecific_i1.76573197
33* MP0004924_abnormal_behavior1.66511897
34* MP0005386_behavior/neurological_phenoty1.66511897
35MP0001984_abnormal_olfaction1.65153353
36MP0000955_abnormal_spinal_cord1.63868190
37MP0003879_abnormal_hair_cell1.56423756
38MP0005646_abnormal_pituitary_gland1.50487275
39MP0002882_abnormal_neuron_morphology1.47461052
40MP0002066_abnormal_motor_capabilities/c1.45132431
41MP0003123_paternal_imprinting1.43443700
42MP0004885_abnormal_endolymph1.42853536
43MP0003633_abnormal_nervous_system1.41361211
44MP0001905_abnormal_dopamine_level1.30260953
45MP0000569_abnormal_digit_pigmentation1.23920494
46MP0003787_abnormal_imprinting1.22506096
47MP0001529_abnormal_vocalization1.21177892
48MP0005645_abnormal_hypothalamus_physiol1.19460644
49MP0003631_nervous_system_phenotype1.18894048
50MP0004142_abnormal_muscle_tone1.16555099
51MP0001502_abnormal_circadian_rhythm1.15480184
52MP0002152_abnormal_brain_morphology1.11666948
53MP0008872_abnormal_physiological_respon1.06851823
54MP0003122_maternal_imprinting1.01560090
55MP0002229_neurodegeneration1.01379745
56MP0004147_increased_porphyrin_level1.00771694
57MP0003121_genomic_imprinting0.98529175
58MP0008874_decreased_physiological_sensi0.97920944
59MP0001188_hyperpigmentation0.95516756
60MP0000751_myopathy0.95259284
61MP0002069_abnormal_eating/drinking_beha0.91897372
62MP0000604_amyloidosis0.90238053
63MP0003634_abnormal_glial_cell0.89612180
64MP0008961_abnormal_basal_metabolism0.87782562
65MP0001177_atelectasis0.86732598
66MP0000920_abnormal_myelination0.85900421
67MP0003075_altered_response_to0.85153343
68MP0005535_abnormal_body_temperature0.83454673
69MP0004742_abnormal_vestibular_system0.83436981
70MP0004145_abnormal_muscle_electrophysio0.82482327
71MP0005551_abnormal_eye_electrophysiolog0.81851011
72MP0003632_abnormal_nervous_system0.81649575
73MP0005499_abnormal_olfactory_system0.80989532
74MP0005394_taste/olfaction_phenotype0.80989532
75MP0003690_abnormal_glial_cell0.80851728
76MP0008877_abnormal_DNA_methylation0.80746186
77MP0004085_abnormal_heartbeat0.80293611
78MP0001963_abnormal_hearing_physiology0.76922282
79MP0002752_abnormal_somatic_nervous0.76280814
80MP0010386_abnormal_urinary_bladder0.75572037
81MP0000013_abnormal_adipose_tissue0.74956121
82MP0002090_abnormal_vision0.72620864
83MP0004130_abnormal_muscle_cell0.70884791
84MP0003283_abnormal_digestive_organ0.68620412
85MP0001986_abnormal_taste_sensitivity0.67252123
86MP0000631_abnormal_neuroendocrine_gland0.65645541
87MP0005409_darkened_coat_color0.64984886
88MP0003172_abnormal_lysosome_physiology0.63556443
89MP0001348_abnormal_lacrimal_gland0.63319039
90MP0001346_abnormal_lacrimal_gland0.63164270
91MP0000026_abnormal_inner_ear0.62890846
92MP0004484_altered_response_of0.62760037
93MP0001664_abnormal_digestion0.61333222
94MP0005623_abnormal_meninges_morphology0.61228550
95MP0010234_abnormal_vibrissa_follicle0.60132804
96MP0004215_abnormal_myocardial_fiber0.60126540
97MP0001299_abnormal_eye_distance/0.59535733
98MP0004233_abnormal_muscle_weight0.59465790
99MP0004510_myositis0.59455485
100MP0000579_abnormal_nail_morphology0.59078821
101MP0010770_preweaning_lethality0.57659668
102MP0002082_postnatal_lethality0.57659668
103MP0002837_dystrophic_cardiac_calcinosis0.57364902
104MP0010768_mortality/aging0.57131734
105MP0003137_abnormal_impulse_conducting0.57117272
106MP0003861_abnormal_nervous_system0.56849299
107MP0001485_abnormal_pinna_reflex0.56225158
108MP0002638_abnormal_pupillary_reflex0.55710868
109MP0001943_abnormal_respiration0.54717463
110MP0010769_abnormal_survival0.54516348
111MP0005187_abnormal_penis_morphology0.54447247
112MP0005167_abnormal_blood-brain_barrier0.53768504
113MP0000566_synostosis0.53168258
114MP0003938_abnormal_ear_development0.50974495
115MP0002653_abnormal_ependyma_morphology0.49694235

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.41104766
2Focal motor seizures (HP:0011153)7.26338564
3Focal seizures (HP:0007359)5.77757382
4Visual hallucinations (HP:0002367)5.34948141
5Epileptic encephalopathy (HP:0200134)4.77520674
6Progressive cerebellar ataxia (HP:0002073)4.42806555
7Atonic seizures (HP:0010819)4.37038333
8Febrile seizures (HP:0002373)4.22290687
9Action tremor (HP:0002345)4.16508853
10Absence seizures (HP:0002121)4.02379606
11Supranuclear gaze palsy (HP:0000605)3.98301470
12Ankle clonus (HP:0011448)3.86181006
13Generalized tonic-clonic seizures (HP:0002069)3.81529854
14Dialeptic seizures (HP:0011146)3.66996803
15Mutism (HP:0002300)3.56150366
16Papilledema (HP:0001085)3.55223692
17Poor eye contact (HP:0000817)3.53484907
18Broad-based gait (HP:0002136)3.51960051
19Urinary bladder sphincter dysfunction (HP:0002839)3.36471884
20Impaired vibration sensation in the lower limbs (HP:0002166)3.34467358
21Depression (HP:0000716)3.31700575
22Gaze-evoked nystagmus (HP:0000640)3.21735004
23Abnormal social behavior (HP:0012433)3.18809508
24Impaired social interactions (HP:0000735)3.18809508
25Postural instability (HP:0002172)3.04883554
26Hyperventilation (HP:0002883)3.03030317
27Truncal ataxia (HP:0002078)3.02380747
28Dysdiadochokinesis (HP:0002075)3.01997990
29Dysmetria (HP:0001310)3.01329749
30Anxiety (HP:0000739)3.01205597
31Urinary urgency (HP:0000012)2.98179357
32Abnormal eating behavior (HP:0100738)2.96747120
33Limb dystonia (HP:0002451)2.94496868
34Torticollis (HP:0000473)2.93879738
35Termporal pattern (HP:0011008)2.90549588
36Insidious onset (HP:0003587)2.90549588
37Genetic anticipation (HP:0003743)2.89680579
38Amblyopia (HP:0000646)2.87172959
39Cerebral hypomyelination (HP:0006808)2.82886219
40Spastic gait (HP:0002064)2.79991663
41Tetraplegia (HP:0002445)2.78915186
42Progressive inability to walk (HP:0002505)2.73189008
43Focal dystonia (HP:0004373)2.70928085
44Abnormality of the lower motor neuron (HP:0002366)2.69298318
45Sleep apnea (HP:0010535)2.68337100
46Abnormality of the corticospinal tract (HP:0002492)2.67722361
47Drooling (HP:0002307)2.66432497
48Excessive salivation (HP:0003781)2.66432497
49Pheochromocytoma (HP:0002666)2.65569368
50Neurofibrillary tangles (HP:0002185)2.64063733
51Cerebral inclusion bodies (HP:0100314)2.62511126
52Impaired smooth pursuit (HP:0007772)2.60163062
53Peripheral hypomyelination (HP:0007182)2.54511195
54Scanning speech (HP:0002168)2.53622590
55Bradykinesia (HP:0002067)2.53600195
56Stereotypic behavior (HP:0000733)2.51603476
57Megalencephaly (HP:0001355)2.46990161
58Intention tremor (HP:0002080)2.46753806
59Diplopia (HP:0000651)2.46616025
60Abnormality of binocular vision (HP:0011514)2.46616025
61Craniofacial dystonia (HP:0012179)2.46216174
62Epileptiform EEG discharges (HP:0011182)2.43479456
63Hemiparesis (HP:0001269)2.38157544
64EEG with generalized epileptiform discharges (HP:0011198)2.37317701
65Fetal akinesia sequence (HP:0001989)2.34542117
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.34178293
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34178293
68Ventricular fibrillation (HP:0001663)2.32666469
69Lower limb muscle weakness (HP:0007340)2.31915410
70Hemiplegia (HP:0002301)2.31349990
71Hypsarrhythmia (HP:0002521)2.28782222
72Abnormality of ocular smooth pursuit (HP:0000617)2.28296671
73Inability to walk (HP:0002540)2.27723172
74Neuroendocrine neoplasm (HP:0100634)2.27393532
75Absent speech (HP:0001344)2.25407137
76Amyotrophic lateral sclerosis (HP:0007354)2.25044944
77Impaired vibratory sensation (HP:0002495)2.24331467
78Agitation (HP:0000713)2.20242748
79Dysmetric saccades (HP:0000641)2.20158350
80Status epilepticus (HP:0002133)2.17906095
81Annular pancreas (HP:0001734)2.17847553
82Polyphagia (HP:0002591)2.17124845
83Diminished motivation (HP:0000745)2.14884812
84Generalized myoclonic seizures (HP:0002123)2.14763826
85Spastic tetraparesis (HP:0001285)2.12827996
86Obstructive sleep apnea (HP:0002870)2.09437310
87Inappropriate behavior (HP:0000719)2.07330925
88Clonus (HP:0002169)2.04715754
89Akinesia (HP:0002304)2.03164556
90Pointed chin (HP:0000307)2.02029029
91Insomnia (HP:0100785)2.01260687
92Split foot (HP:0001839)1.95239649
93Neuronal loss in central nervous system (HP:0002529)1.93409112
94Incomplete penetrance (HP:0003829)1.93002325
95Gait ataxia (HP:0002066)1.91487546
96Rigidity (HP:0002063)1.90608159
97Lower limb amyotrophy (HP:0007210)1.90027313
98Choreoathetosis (HP:0001266)1.89932704
99Rapidly progressive (HP:0003678)1.89851178
100Neoplasm of the peripheral nervous system (HP:0100007)1.89440351
101Aplasia involving bones of the extremities (HP:0009825)1.88347512
102Aplasia involving bones of the upper limbs (HP:0009823)1.88347512
103Aplasia of the phalanges of the hand (HP:0009802)1.88347512
104Apathy (HP:0000741)1.87774152
105CNS hypomyelination (HP:0003429)1.87672484
106Spastic tetraplegia (HP:0002510)1.85650684
107Blue irides (HP:0000635)1.83388393
108Delusions (HP:0000746)1.81044040
109Lower limb asymmetry (HP:0100559)1.80525905
110Abnormality of salivation (HP:0100755)1.79610029
111Bundle branch block (HP:0011710)1.79087687
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78750391
113Morphological abnormality of the pyramidal tract (HP:0002062)1.78198117
114Abnormality of saccadic eye movements (HP:0000570)1.78020848
115Hypoventilation (HP:0002791)1.77497204
116Increased circulating renin level (HP:0000848)1.71756565
117Hypoplasia of the corpus callosum (HP:0002079)1.68494648
118Bronchomalacia (HP:0002780)1.67969125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.25860397
2NTRK34.22185286
3EPHA43.76877952
4MARK13.68337621
5MAP3K43.06976905
6MINK12.90319521
7DAPK22.63408476
8MAP2K72.54995158
9PAK62.39166268
10KSR22.31901676
11NTRK12.10537033
12NTRK22.04900411
13MAP3K122.04439966
14MAP2K41.97226878
15PRKD31.93885379
16CAMKK11.93314930
17RIPK41.63301853
18CDK51.58622691
19KSR11.58251085
20DAPK11.57894630
21GRK51.54653209
22CDK191.51432676
23CASK1.48939552
24LATS21.41977324
25PLK21.41454336
26MAP3K21.40639670
27MAPK131.35362363
28PHKG21.31666547
29PHKG11.31666547
30PNCK1.29890441
31ARAF1.29541427
32STK381.28299360
33SIK21.23686535
34TNIK1.20282297
35PRKCG1.17144934
36TAOK11.15817419
37UHMK11.15429649
38CAMKK21.11915780
39PRPF4B1.09511535
40TYRO31.07400837
41FES1.06218993
42RET1.04234976
43CDK180.97995308
44CDK140.97219968
45CDK150.96522731
46LMTK20.94661441
47STK110.93234839
48CAMK2A0.91787506
49CAMK10.90223469
50MAP3K130.90206243
51CSNK1G20.87514133
52CDK11A0.84778142
53SGK2230.84532103
54SGK4940.84532103
55PAK30.83048400
56PRKCH0.82017456
57PKN10.81886531
58ALK0.79971071
59OXSR10.78042294
60RAF10.76450210
61MARK20.72769157
62NEK60.72746055
63PDK10.68343743
64MAP3K110.67384882
65CAMK2B0.67376388
66DYRK20.66989141
67PINK10.65160388
68PTK2B0.64674425
69SGK20.63705071
70DYRK1A0.63538090
71SCYL20.62482168
72PDPK10.61405050
73SGK30.61170729
74MAP3K10.60373753
75SGK10.59652064
76NEK10.58251769
77PRKCZ0.54608658
78BRAF0.54306573
79CCNB10.53662186
80FYN0.45787126
81RPS6KA30.45379315
82RIPK10.45149970
83CAMK1G0.44422269
84BMPR20.44159291
85ROCK20.44014709
86MAP2K10.43401920
87FGFR20.42731659
88WNK10.42652720
89PRKCE0.42423595
90RPS6KA20.41571461
91DAPK30.41387163
92MAPK100.40212958
93CAMK2G0.39906958
94TNK20.38674027
95MAP3K60.38173642
96CAMK40.37923311
97MAP3K70.37826535
98BRSK10.37646167
99CDC42BPA0.37476694
100CAMK2D0.36818874
101MAPK120.36480739
102FER0.34132721
103CAMK1D0.33912674
104ERBB20.33603314
105LIMK10.33178934
106PRKG10.30835370
107MAPKAPK50.30384500
108PRKCA0.30075759
109CSNK1E0.29633527
110WNK30.28956709
111CSNK1G30.28927009
112PRKCB0.28406474
113ROCK10.27244999
114PRKACA0.26230666
115MAPK80.25881023
116CSNK1D0.25294086

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.49592802
2Nicotine addiction_Homo sapiens_hsa050333.37387665
3Olfactory transduction_Homo sapiens_hsa047402.89710667
4Circadian entrainment_Homo sapiens_hsa047132.62866814
5Long-term potentiation_Homo sapiens_hsa047202.61412328
6GABAergic synapse_Homo sapiens_hsa047272.60678458
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52682882
8Glutamatergic synapse_Homo sapiens_hsa047242.49363035
9Morphine addiction_Homo sapiens_hsa050322.39968204
10Amphetamine addiction_Homo sapiens_hsa050312.39104030
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36884011
12Dopaminergic synapse_Homo sapiens_hsa047282.21442073
13Salivary secretion_Homo sapiens_hsa049702.15168101
14Insulin secretion_Homo sapiens_hsa049111.99062142
15Cholinergic synapse_Homo sapiens_hsa047251.96635635
16Gastric acid secretion_Homo sapiens_hsa049711.90653526
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81731437
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70412368
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67643874
20Cocaine addiction_Homo sapiens_hsa050301.65386282
21Renin secretion_Homo sapiens_hsa049241.64723366
22Long-term depression_Homo sapiens_hsa047301.64052330
23Taste transduction_Homo sapiens_hsa047421.63609691
24Oxytocin signaling pathway_Homo sapiens_hsa049211.62947957
25Serotonergic synapse_Homo sapiens_hsa047261.61308370
26GnRH signaling pathway_Homo sapiens_hsa049121.47689005
27Calcium signaling pathway_Homo sapiens_hsa040201.46824776
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43797203
29Gap junction_Homo sapiens_hsa045401.40049306
30Collecting duct acid secretion_Homo sapiens_hsa049661.38652369
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36860503
32Glioma_Homo sapiens_hsa052141.22977941
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22614016
34Vitamin B6 metabolism_Homo sapiens_hsa007501.22540492
35cAMP signaling pathway_Homo sapiens_hsa040241.22412069
36Estrogen signaling pathway_Homo sapiens_hsa049151.21158676
37Type II diabetes mellitus_Homo sapiens_hsa049301.19828835
38Axon guidance_Homo sapiens_hsa043601.15803781
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11765251
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11561736
41ErbB signaling pathway_Homo sapiens_hsa040121.10768842
42Nitrogen metabolism_Homo sapiens_hsa009101.08432859
43Melanogenesis_Homo sapiens_hsa049161.04768264
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99682849
45Dorso-ventral axis formation_Homo sapiens_hsa043200.95350635
46Oocyte meiosis_Homo sapiens_hsa041140.94300213
47Cardiac muscle contraction_Homo sapiens_hsa042600.89808495
48Vibrio cholerae infection_Homo sapiens_hsa051100.89153914
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.88125199
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.85686530
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85160427
52Phototransduction_Homo sapiens_hsa047440.84729831
53Pancreatic secretion_Homo sapiens_hsa049720.79297679
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.77578900
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76705803
56Thyroid hormone synthesis_Homo sapiens_hsa049180.75916007
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75175986
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73037705
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72537595
60Choline metabolism in cancer_Homo sapiens_hsa052310.71886937
61MAPK signaling pathway_Homo sapiens_hsa040100.71173729
62VEGF signaling pathway_Homo sapiens_hsa043700.70678353
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65126242
64Dilated cardiomyopathy_Homo sapiens_hsa054140.63727874
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.62596556
66Ras signaling pathway_Homo sapiens_hsa040140.61199328
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60602276
68mTOR signaling pathway_Homo sapiens_hsa041500.59582477
69Endocytosis_Homo sapiens_hsa041440.58315992
70Rap1 signaling pathway_Homo sapiens_hsa040150.57234876
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56288505
72Endometrial cancer_Homo sapiens_hsa052130.56184922
73Glucagon signaling pathway_Homo sapiens_hsa049220.56106952
74Alcoholism_Homo sapiens_hsa050340.53661346
75Bile secretion_Homo sapiens_hsa049760.50464532
76Renal cell carcinoma_Homo sapiens_hsa052110.49194702
77Insulin signaling pathway_Homo sapiens_hsa049100.49093865
78Non-small cell lung cancer_Homo sapiens_hsa052230.48553879
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48421916
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46177802
81Prion diseases_Homo sapiens_hsa050200.45869497
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45835045
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45586552
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45257920
85Inositol phosphate metabolism_Homo sapiens_hsa005620.44588603
86Type I diabetes mellitus_Homo sapiens_hsa049400.43368544
87Alzheimers disease_Homo sapiens_hsa050100.42233629
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41273233
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41032231
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40604573
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39216317
92Wnt signaling pathway_Homo sapiens_hsa043100.39118251
93Chemokine signaling pathway_Homo sapiens_hsa040620.36701547
94Circadian rhythm_Homo sapiens_hsa047100.35307937
95Colorectal cancer_Homo sapiens_hsa052100.34081895
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34055422
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33091539
98African trypanosomiasis_Homo sapiens_hsa051430.32035661
99AMPK signaling pathway_Homo sapiens_hsa041520.30871700
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30246291
101Hippo signaling pathway_Homo sapiens_hsa043900.30123489
102Ovarian steroidogenesis_Homo sapiens_hsa049130.29914580
103Fatty acid biosynthesis_Homo sapiens_hsa000610.29201796
104Prolactin signaling pathway_Homo sapiens_hsa049170.27612971
105Tight junction_Homo sapiens_hsa045300.27421764
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27327301
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24721751
108Arginine and proline metabolism_Homo sapiens_hsa003300.24390446
109Arginine biosynthesis_Homo sapiens_hsa002200.20326133
110Mineral absorption_Homo sapiens_hsa049780.18749985
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18735398

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