ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	inner ear receptor cell differentiation (GO:0060113)	6.32639981
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.23212062
3	auditory receptor cell differentiation (GO:0042491)	5.26117257
4	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	4.63983345
5	brain morphogenesis (GO:0048854)	4.59475227
6	regulation of sequestering of triglyceride (GO:0010889)	4.50814495
7	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.43038989
8	type B pancreatic cell development (GO:0003323)	4.41294513
9	negative regulation of glucose import (GO:0046325)	4.36125258
10	mechanoreceptor differentiation (GO:0042490)	4.34193064
11	glycerophospholipid catabolic process (GO:0046475)	4.20891280
12	peroxisome fission (GO:0016559)	4.13923113
13	nonmotile primary cilium assembly (GO:0035058)	4.08488733
14	response to pheromone (GO:0019236)	4.05082501
15	epithelial cilium movement (GO:0003351)	3.87525323
16	protein prenylation (GO:0018342)	3.80556637
17	prenylation (GO:0097354)	3.80556637
18	potassium ion homeostasis (GO:0055075)	3.69535069
19	negative regulation of macroautophagy (GO:0016242)	3.61667230
20	cellular potassium ion homeostasis (GO:0030007)	3.59237313
21	regulation of response to food (GO:0032095)	3.52058929
22	cellular ketone body metabolic process (GO:0046950)	3.37111426
23	glandular epithelial cell development (GO:0002068)	3.28880320
24	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.28588872
25	synaptic transmission, cholinergic (GO:0007271)	3.26614528
26	neurotransmitter uptake (GO:0001504)	3.26392722
27	RNA destabilization (GO:0050779)	3.24902920
28	regulation of cilium movement (GO:0003352)	3.22777055
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.22266294
30	epithelial cell maturation (GO:0002070)	3.20646150
31	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.19824589
32	thalamus development (GO:0021794)	3.18973264
33	inositol phosphate dephosphorylation (GO:0046855)	3.13633089
34	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.13633089
35	protein complex biogenesis (GO:0070271)	3.12111983
36	regulation of cell proliferation involved in kidney development (GO:1901722)	3.11579957
37	inositol phosphate catabolic process (GO:0071545)	3.11413330
38	negative regulation of glucose transport (GO:0010829)	3.11132806
39	L-fucose catabolic process (GO:0042355)	3.10450180
40	fucose catabolic process (GO:0019317)	3.10450180
41	L-fucose metabolic process (GO:0042354)	3.10450180
42	neuron fate specification (GO:0048665)	3.09953024
43	axoneme assembly (GO:0035082)	3.09546223
44	potassium ion import (GO:0010107)	3.07164885
45	regulation of synaptic transmission, dopaminergic (GO:0032225)	3.06759000
46	central nervous system myelination (GO:0022010)	3.04775248
47	axon ensheathment in central nervous system (GO:0032291)	3.04775248
48	dentate gyrus development (GO:0021542)	3.00763675
49	TOR signaling (GO:0031929)	2.96269145
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.95316527
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.95316527
52	NADH dehydrogenase complex assembly (GO:0010257)	2.95316527
53	nephron tubule morphogenesis (GO:0072078)	2.95118687
54	nephron epithelium morphogenesis (GO:0072088)	2.95118687
55	astrocyte differentiation (GO:0048708)	2.93498097
56	ketone body metabolic process (GO:1902224)	2.92804369
57	histone H2A monoubiquitination (GO:0035518)	2.88395182
58	behavioral response to nicotine (GO:0035095)	2.88327531
59	positive regulation of organelle assembly (GO:1902117)	2.84753799
60	negative regulation of Rho protein signal transduction (GO:0035024)	2.82319101
61	renal tubule morphogenesis (GO:0061333)	2.80673883
62	reflex (GO:0060004)	2.80493356
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76845328
64	neuron fate determination (GO:0048664)	2.74361343
65	dendritic spine morphogenesis (GO:0060997)	2.73398105
66	protein polyglutamylation (GO:0018095)	2.71450737
67	GTP biosynthetic process (GO:0006183)	2.69398022
68	startle response (GO:0001964)	2.69230658
69	atrial cardiac muscle cell action potential (GO:0086014)	2.68882071
70	polyol catabolic process (GO:0046174)	2.67375159
71	mannosylation (GO:0097502)	2.66585334
72	negative regulation of response to nutrient levels (GO:0032108)	2.65811855
73	negative regulation of response to extracellular stimulus (GO:0032105)	2.65811855
74	presynaptic membrane assembly (GO:0097105)	2.65368350
75	neuron maturation (GO:0042551)	2.64751386
76	cilium movement (GO:0003341)	2.64330293
77	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.63990344
78	regulation of microtubule-based movement (GO:0060632)	2.63227496
79	water-soluble vitamin biosynthetic process (GO:0042364)	2.62791504
80	regulation of membrane repolarization (GO:0060306)	2.62656753
81	transmission of nerve impulse (GO:0019226)	2.61252197
82	histone H2A ubiquitination (GO:0033522)	2.60671451
83	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.59346915
84	cardiac left ventricle morphogenesis (GO:0003214)	2.59337683
85	synapse assembly (GO:0007416)	2.59302788
86	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.56720993
87	cilium morphogenesis (GO:0060271)	2.55175134
88	auditory receptor cell stereocilium organization (GO:0060088)	2.54554595
89	cobalamin metabolic process (GO:0009235)	2.54080552
90	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.53339704
91	regulation of glomerulus development (GO:0090192)	2.52367142
92	limb development (GO:0060173)	2.49899433
93	appendage development (GO:0048736)	2.49899433
94	hair cell differentiation (GO:0035315)	2.47575824
95	protein localization to cilium (GO:0061512)	2.46683944
96	cilium assembly (GO:0042384)	2.45789652
97	cilium organization (GO:0044782)	2.44277748
98	serotonin metabolic process (GO:0042428)	2.43837930
99	neuron cell-cell adhesion (GO:0007158)	2.43652737
100	kynurenine metabolic process (GO:0070189)	2.41947744

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.85488168
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.76816375
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.75690779
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.73691616
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.64860158
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.62389762
7	VDR_22108803_ChIP-Seq_LS180_Human	2.59348589
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.52254766
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.38506977
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37838392
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.25438807
12	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.21507389
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.17912290
14	REST_21632747_ChIP-Seq_MESCs_Mouse	2.09837662
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.06901340
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.04833265
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.02069540
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01302459
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00700460
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.97270392
21	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.92251635
22	EWS_26573619_Chip-Seq_HEK293_Human	1.90312626
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.88087831
24	FUS_26573619_Chip-Seq_HEK293_Human	1.85750088
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.82247262
26	P300_19829295_ChIP-Seq_ESCs_Human	1.81375151
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80478452
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.77807210
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.75316604
30	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.71829814
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71386329
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66785909
33	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.65092869
34	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.63908442
35	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.61129185
36	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.58334030
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57549380
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.54198757
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53707566
40	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.53049994
41	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52820789
42	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52820789
43	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.50616227
44	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.49735390
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48638487
46	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.48519888
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47210393
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46314985
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41546819
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.40379404
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.37823574
52	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.37819134
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36188289
54	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.35288187
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31241277
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30753253
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29317997
58	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.29126630
59	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.27831449
60	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.27119975
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26499284
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26220770
63	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.26122935
64	TCF4_23295773_ChIP-Seq_U87_Human	1.25284195
65	AR_25329375_ChIP-Seq_VCAP_Human	1.24087998
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23651817
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.21615922
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19248678
69	AHR_22903824_ChIP-Seq_MCF-7_Human	1.18006999
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17163249
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15617616
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13269714
73	STAT3_23295773_ChIP-Seq_U87_Human	1.11992392
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10231356
75	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.09395079
76	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09166812
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09157528
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.08841304
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08379361
80	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.07388552
81	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.04005265
82	DROSHA_22980978_ChIP-Seq_HELA_Human	1.03711659
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03469923
84	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03107338
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03107338
86	BCAT_22108803_ChIP-Seq_LS180_Human	1.01571341
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.00699168
88	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.00528937
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00394822
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99115957
91	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98726511
92	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98712117
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98387167
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98253744
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97752598
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96874611
97	* GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96067820
98	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.95390649
99	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.95331972
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.95297137

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.38661195
2	MP0005423_abnormal_somatic_nervous	3.01690571
3	MP0003787_abnormal_imprinting	2.96597115
4	MP0003646_muscle_fatigue	2.93335484
5	MP0006072_abnormal_retinal_apoptosis	2.78091437
6	MP0009379_abnormal_foot_pigmentation	2.71989425
7	MP0003122_maternal_imprinting	2.48963566
8	MP0002909_abnormal_adrenal_gland	2.41475143
9	MP0008877_abnormal_DNA_methylation	2.37489390
10	MP0001501_abnormal_sleep_pattern	2.28817214
11	MP0002638_abnormal_pupillary_reflex	2.17400769
12	MP0002272_abnormal_nervous_system	2.13548398
13	MP0008775_abnormal_heart_ventricle	2.05795365
14	MP0009046_muscle_twitch	2.05457463
15	MP0000372_irregular_coat_pigmentation	2.03244191
16	MP0006292_abnormal_olfactory_placode	1.98392928
17	MP0004133_heterotaxia	1.97475320
18	MP0000631_abnormal_neuroendocrine_gland	1.95479106
19	MP0003123_paternal_imprinting	1.89936454
20	MP0001529_abnormal_vocalization	1.88865728
21	MP0004270_analgesia	1.86005580
22	MP0001968_abnormal_touch/_nociception	1.80846400
23	MP0005379_endocrine/exocrine_gland_phen	1.80379251
24	MP0001984_abnormal_olfaction	1.77035417
25	MP0003880_abnormal_central_pattern	1.70789360
26	MP0005551_abnormal_eye_electrophysiolog	1.68795111
27	MP0002163_abnormal_gland_morphology	1.67945474
28	MP0003635_abnormal_synaptic_transmissio	1.64706453
29	MP0002837_dystrophic_cardiac_calcinosis	1.60309551
30	MP0002736_abnormal_nociception_after	1.59572703
31	MP0002572_abnormal_emotion/affect_behav	1.55475143
32	MP0003121_genomic_imprinting	1.54776883
33	MP0010386_abnormal_urinary_bladder	1.51818272
34	MP0002064_seizures	1.48441735
35	MP0006276_abnormal_autonomic_nervous	1.47057563
36	MP0009745_abnormal_behavioral_response	1.45277491
37	MP0005253_abnormal_eye_physiology	1.44702216
38	MP0002734_abnormal_mechanical_nocicepti	1.42763349
39	MP0005174_abnormal_tail_pigmentation	1.42118577
40	MP0001986_abnormal_taste_sensitivity	1.41076571
41	MP0000383_abnormal_hair_follicle	1.40898479
42	MP0008789_abnormal_olfactory_epithelium	1.40729212
43	MP0004924_abnormal_behavior	1.38973339
44	MP0005386_behavior/neurological_phenoty	1.38973339
45	MP0001944_abnormal_pancreas_morphology	1.38447999
46	MP0004233_abnormal_muscle_weight	1.37330786
47	MP0004742_abnormal_vestibular_system	1.36664134
48	MP0009384_cardiac_valve_regurgitation	1.33621013
49	MP0001485_abnormal_pinna_reflex	1.33115686
50	MP0002557_abnormal_social/conspecific_i	1.32773519
51	MP0002063_abnormal_learning/memory/cond	1.32286680
52	MP0005645_abnormal_hypothalamus_physiol	1.31351683
53	MP0002184_abnormal_innervation	1.29759122
54	MP0009780_abnormal_chondrocyte_physiolo	1.26859421
55	MP0004885_abnormal_endolymph	1.26741498
56	MP0001661_extended_life_span	1.26046798
57	MP0004859_abnormal_synaptic_plasticity	1.25334561
58	MP0002938_white_spotting	1.24486806
59	MP0001970_abnormal_pain_threshold	1.18977931
60	MP0000427_abnormal_hair_cycle	1.17297783
61	MP0005310_abnormal_salivary_gland	1.17212655
62	MP0008875_abnormal_xenobiotic_pharmacok	1.14390550
63	MP0002733_abnormal_thermal_nociception	1.11945517
64	MP0002229_neurodegeneration	1.08960173
65	MP0002067_abnormal_sensory_capabilities	1.08542025
66	MP0001502_abnormal_circadian_rhythm	1.06572470
67	MP0004142_abnormal_muscle_tone	1.06268651
68	MP0002277_abnormal_respiratory_mucosa	1.05158852
69	MP0001905_abnormal_dopamine_level	0.99790113
70	MP0000778_abnormal_nervous_system	0.99340924
71	MP0002160_abnormal_reproductive_system	0.98735203
72	MP0002102_abnormal_ear_morphology	0.98228635
73	MP0002882_abnormal_neuron_morphology	0.97674918
74	MP0002752_abnormal_somatic_nervous	0.97418484
75	MP0000955_abnormal_spinal_cord	0.97400681
76	MP0005394_taste/olfaction_phenotype	0.96641512
77	MP0005499_abnormal_olfactory_system	0.96641512
78	MP0010678_abnormal_skin_adnexa	0.94345990
79	MP0003011_delayed_dark_adaptation	0.93370338
80	MP0000026_abnormal_inner_ear	0.92030314
81	MP0001188_hyperpigmentation	0.91837929
82	MP0003283_abnormal_digestive_organ	0.91535459
83	MP0003879_abnormal_hair_cell	0.91034049
84	MP0001963_abnormal_hearing_physiology	0.89903510
85	MP0001486_abnormal_startle_reflex	0.88909988
86	MP0000516_abnormal_urinary_system	0.88646361
87	MP0005367_renal/urinary_system_phenotyp	0.88646361
88	MP0005535_abnormal_body_temperature	0.87428686
89	MP0002653_abnormal_ependyma_morphology	0.87322881
90	MP0002095_abnormal_skin_pigmentation	0.85635539
91	MP0002735_abnormal_chemical_nociception	0.85627254
92	MP0005195_abnormal_posterior_eye	0.83186005
93	MP0002822_catalepsy	0.79401931
94	MP0002254_reproductive_system_inflammat	0.78742911
95	MP0003959_abnormal_lean_body	0.78251784
96	MP0005389_reproductive_system_phenotype	0.76326928
97	MP0005620_abnormal_muscle_contractility	0.75345736
98	MP0008872_abnormal_physiological_respon	0.75318113
99	MP0003119_abnormal_digestive_system	0.74732625
100	MP0004147_increased_porphyrin_level	0.72718874

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Homocystinuria (HP:0002156)	5.47437579
2	Abnormality of homocysteine metabolism (HP:0010919)	5.47437579
3	Facial shape deformation (HP:0011334)	4.98689866
4	Potter facies (HP:0002009)	4.98689866
5	Methylmalonic acidemia (HP:0002912)	4.75739884
6	Septate vagina (HP:0001153)	4.16184027
7	Methylmalonic aciduria (HP:0012120)	3.69324921
8	Stomatitis (HP:0010280)	3.63124413
9	Duplicated collecting system (HP:0000081)	3.56265469
10	Large for gestational age (HP:0001520)	3.52566586
11	Pancreatic fibrosis (HP:0100732)	3.37562851
12	Submucous cleft hard palate (HP:0000176)	3.25983265
13	Abnormality of the renal collecting system (HP:0004742)	3.16507608
14	Pancreatic cysts (HP:0001737)	3.10355248
15	Medial flaring of the eyebrow (HP:0010747)	3.08128004
16	Molar tooth sign on MRI (HP:0002419)	3.07358548
17	Abnormality of midbrain morphology (HP:0002418)	3.07358548
18	Abnormality of vitamin B metabolism (HP:0004340)	3.06061712
19	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.95639055
20	Gait imbalance (HP:0002141)	2.87360428
21	Type II lissencephaly (HP:0007260)	2.85592740
22	Abnormality of methionine metabolism (HP:0010901)	2.82103386
23	Congenital primary aphakia (HP:0007707)	2.78580072
24	Abnormal biliary tract physiology (HP:0012439)	2.77723319
25	Bile duct proliferation (HP:0001408)	2.77723319
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.67306495
27	Redundant skin (HP:0001582)	2.63322843
28	Long foot (HP:0001833)	2.61822469
29	Nephrogenic diabetes insipidus (HP:0009806)	2.58050286
30	Status epilepticus (HP:0002133)	2.49305904
31	Optic nerve coloboma (HP:0000588)	2.47660322
32	Megaloblastic anemia (HP:0001889)	2.47214260
33	True hermaphroditism (HP:0010459)	2.44382921
34	Cerebellar dysplasia (HP:0007033)	2.44201015
35	Epileptic encephalopathy (HP:0200134)	2.43099032
36	Broad-based gait (HP:0002136)	2.39572565
37	Bony spicule pigmentary retinopathy (HP:0007737)	2.35581577
38	Poor coordination (HP:0002370)	2.31149531
39	Abnormality of vitamin metabolism (HP:0100508)	2.24844314
40	Nephronophthisis (HP:0000090)	2.22810220
41	Febrile seizures (HP:0002373)	2.21932892
42	Acute necrotizing encephalopathy (HP:0006965)	2.21876810
43	Hepatic necrosis (HP:0002605)	2.21000641
44	Pendular nystagmus (HP:0012043)	2.19961195
45	Attenuation of retinal blood vessels (HP:0007843)	2.15878538
46	Vaginal atresia (HP:0000148)	2.13018702
47	Agitation (HP:0000713)	2.11785903
48	Cystic liver disease (HP:0006706)	2.10008220
49	Colon cancer (HP:0003003)	2.09228270
50	Ketosis (HP:0001946)	2.08846309
51	Progressive macrocephaly (HP:0004481)	2.07506053
52	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.07202180
53	Chorioretinal coloboma (HP:0000567)	2.06767944
54	Hyperventilation (HP:0002883)	2.06731917
55	Abolished electroretinogram (ERG) (HP:0000550)	2.06499370
56	Mitochondrial inheritance (HP:0001427)	2.05824311
57	Reticulocytopenia (HP:0001896)	2.04278874
58	Dicarboxylic aciduria (HP:0003215)	2.03718985
59	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.03718985
60	Genital tract atresia (HP:0001827)	2.00419966
61	Persistence of primary teeth (HP:0006335)	1.97825267
62	Neoplasm of the adrenal cortex (HP:0100641)	1.97438536
63	Hemiparesis (HP:0001269)	1.94301736
64	Hyperglycinuria (HP:0003108)	1.93551260
65	Increased number of teeth (HP:0011069)	1.93143132
66	Abnormal mitochondria in muscle tissue (HP:0008316)	1.89387307
67	Congenital stationary night blindness (HP:0007642)	1.88697174
68	Absent thumb (HP:0009777)	1.88420225
69	Adactyly (HP:0009776)	1.83067768
70	Furrowed tongue (HP:0000221)	1.83057332
71	Epileptiform EEG discharges (HP:0011182)	1.80249246
72	Acute encephalopathy (HP:0006846)	1.79695353
73	Severe muscular hypotonia (HP:0006829)	1.79012638
74	Abnormality of the renal medulla (HP:0100957)	1.78796416
75	EEG with generalized epileptiform discharges (HP:0011198)	1.78779265
76	Pancytopenia (HP:0001876)	1.78761441
77	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.77982841
78	Oligodontia (HP:0000677)	1.77183136
79	Non-midline cleft lip (HP:0100335)	1.77006010
80	Exotropia (HP:0000577)	1.76893008
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.76878616
82	Progressive cerebellar ataxia (HP:0002073)	1.74638962
83	Enlarged penis (HP:0000040)	1.73512117
84	Abnormality of renal resorption (HP:0011038)	1.72710477
85	Ketoacidosis (HP:0001993)	1.72396608
86	Abnormal EKG (HP:0003115)	1.71963677
87	Prolonged QT interval (HP:0001657)	1.71219957
88	Hypothermia (HP:0002045)	1.70925092
89	Left ventricular hypertrophy (HP:0001712)	1.70500211
90	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.70366526
91	Preaxial hand polydactyly (HP:0001177)	1.69630226
92	Anencephaly (HP:0002323)	1.67835996
93	Vascular calcification (HP:0004934)	1.67562294
94	Decreased central vision (HP:0007663)	1.67307758
95	Severe visual impairment (HP:0001141)	1.67038005
96	Abnormality of macular pigmentation (HP:0008002)	1.66445267
97	Hepatocellular necrosis (HP:0001404)	1.64674348
98	Abnormality of the vitreous humor (HP:0004327)	1.64402724
99	Increased CSF lactate (HP:0002490)	1.64168692
100	Leukodystrophy (HP:0002415)	1.64164345

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.48385319
2	FRK	4.91718819
3	STK16	3.55889209
4	IRAK2	3.04732244
5	AKT3	2.79704816
6	PINK1	2.57047136
7	CAMKK2	2.31091616
8	WNK4	2.24511425
9	MAP3K4	2.21755596
10	FGFR2	2.20938064
11	STK39	2.08495376
12	INSRR	1.91598292
13	MAP2K7	1.84303754
14	DAPK2	1.79960051
15	NUAK1	1.74095365
16	PAK3	1.72452232
17	VRK1	1.67515053
18	TAF1	1.54706981
19	GRK1	1.53914038
20	PIK3CA	1.51441213
21	BMPR1B	1.49778177
22	ADRBK2	1.48662744
23	RET	1.39366184
24	PRKD3	1.37376478
25	BRSK2	1.28386310
26	CAMK1D	1.22938358
27	MELK	1.21490211
28	RPS6KB1	1.18599567
29	CAMK1G	1.17843683
30	TAOK3	1.17600355
31	CAMKK1	1.13381086
32	STK11	1.11733398
33	MAP3K5	1.11621212
34	PRKD2	1.07023583
35	PRKAA1	1.05064324
36	MAP2K4	1.04402266
37	OXSR1	1.04173676
38	PNCK	1.03907774
39	PHKG2	1.02504157
40	PHKG1	1.02504157
41	NTRK3	1.01050167
42	TAOK1	1.00524766
43	PRKCE	0.98538456
44	NTRK2	0.98251957
45	DYRK1B	0.95277268
46	MAPK13	0.93472345
47	PRKG1	0.89624833
48	CAMK2A	0.84257554
49	PRKCG	0.80548456
50	PASK	0.79512050
51	ERBB2	0.76543025
52	PRKCH	0.75716243
53	VRK2	0.74060944
54	PTK2B	0.73476253
55	MAPK11	0.71235115
56	BMX	0.70338230
57	CASK	0.70122931
58	BRAF	0.69658311
59	LIMK1	0.67753699
60	MAP3K9	0.65976831
61	DYRK2	0.65333356
62	DAPK3	0.64209687
63	PRKCQ	0.62051472
64	GRK5	0.61104947
65	MET	0.57800107
66	WNK3	0.56983342
67	CSNK1A1L	0.54162152
68	MAP2K2	0.52621472
69	SGK223	0.52283409
70	SGK494	0.52283409
71	CSNK1G3	0.51732643
72	PRKACA	0.51507068
73	CAMK1	0.51281583
74	CAMK2D	0.50432774
75	MST4	0.49963739
76	CSNK1G2	0.49560147
77	PRKAA2	0.48477009
78	PDK1	0.48472888
79	HIPK2	0.47160287
80	UHMK1	0.45357797
81	SGK2	0.44915371
82	CHUK	0.43450623
83	MUSK	0.42984618
84	MAPK15	0.41958580
85	ERBB4	0.41663286
86	MAP3K12	0.38171768
87	PDPK1	0.38158519
88	MAP2K6	0.38032553
89	PRKCA	0.37330277
90	BCKDK	0.36735455
91	ACVR1B	0.35706706
92	CSNK1A1	0.35126660
93	TYRO3	0.34812549
94	STK4	0.34159113
95	STK38L	0.33589914
96	MARK1	0.32285626
97	PLK3	0.31701275
98	BRSK1	0.31587229
99	DAPK1	0.31120172
100	RPS6KA3	0.30337556

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.89207566
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.13920392
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64834947
4	Nicotine addiction_Homo sapiens_hsa05033	2.40650210
5	Basal transcription factors_Homo sapiens_hsa03022	2.30131641
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.22514739
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.06104016
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.05130155
9	Butanoate metabolism_Homo sapiens_hsa00650	2.02197005
10	Parkinsons disease_Homo sapiens_hsa05012	1.92482623
11	GABAergic synapse_Homo sapiens_hsa04727	1.90850295
12	Insulin secretion_Homo sapiens_hsa04911	1.87039921
13	Taste transduction_Homo sapiens_hsa04742	1.80020233
14	Morphine addiction_Homo sapiens_hsa05032	1.76099195
15	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.70500153
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.61359276
17	Serotonergic synapse_Homo sapiens_hsa04726	1.59014522
18	Circadian entrainment_Homo sapiens_hsa04713	1.55991245
19	RNA polymerase_Homo sapiens_hsa03020	1.55160875
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.47525051
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.45966075
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.44964728
23	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.43380262
24	Sulfur relay system_Homo sapiens_hsa04122	1.40732731
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39127809
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37530694
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.35995268
28	Regulation of autophagy_Homo sapiens_hsa04140	1.35594743
29	Alzheimers disease_Homo sapiens_hsa05010	1.34823898
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.33991504
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.32296923
32	Huntingtons disease_Homo sapiens_hsa05016	1.30920285
33	Peroxisome_Homo sapiens_hsa04146	1.30686050
34	Salivary secretion_Homo sapiens_hsa04970	1.30352145
35	Melanoma_Homo sapiens_hsa05218	1.29059393
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.27616019
37	Folate biosynthesis_Homo sapiens_hsa00790	1.23784993
38	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.22401802
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.18317802
40	Ribosome_Homo sapiens_hsa03010	1.17255211
41	Dopaminergic synapse_Homo sapiens_hsa04728	1.17014613
42	Protein export_Homo sapiens_hsa03060	1.15429168
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07679879
44	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.07142265
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.06998365
46	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05889321
47	RNA degradation_Homo sapiens_hsa03018	1.04277611
48	Long-term depression_Homo sapiens_hsa04730	1.03042075
49	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.02510919
50	Circadian rhythm_Homo sapiens_hsa04710	0.98214321
51	Phototransduction_Homo sapiens_hsa04744	0.96664298
52	Amphetamine addiction_Homo sapiens_hsa05031	0.91901052
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.91861661
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.91432668
55	Gastric acid secretion_Homo sapiens_hsa04971	0.84837850
56	Cocaine addiction_Homo sapiens_hsa05030	0.84396459
57	mTOR signaling pathway_Homo sapiens_hsa04150	0.80657798
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80236371
59	Renin secretion_Homo sapiens_hsa04924	0.79080844
60	Cholinergic synapse_Homo sapiens_hsa04725	0.78443195
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76602364
62	Olfactory transduction_Homo sapiens_hsa04740	0.74705962
63	ABC transporters_Homo sapiens_hsa02010	0.73115021
64	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72696140
65	Mineral absorption_Homo sapiens_hsa04978	0.72674806
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.72549398
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69368332
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.66890310
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66500568
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.63852277
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.63834633
72	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.63288494
73	Choline metabolism in cancer_Homo sapiens_hsa05231	0.62614025
74	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.58998022
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55716527
76	Type II diabetes mellitus_Homo sapiens_hsa04930	0.55211907
77	Pancreatic secretion_Homo sapiens_hsa04972	0.54249884
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.50784854
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48894047
80	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47980198
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45395399
82	Metabolic pathways_Homo sapiens_hsa01100	0.44345018
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.43388243
84	Bile secretion_Homo sapiens_hsa04976	0.42688683
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42548500
86	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.41792849
87	Histidine metabolism_Homo sapiens_hsa00340	0.41409695
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41321411
89	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40934677
90	Ras signaling pathway_Homo sapiens_hsa04014	0.40623046
91	Purine metabolism_Homo sapiens_hsa00230	0.40606605
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39409528
93	Renin-angiotensin system_Homo sapiens_hsa04614	0.38730725
94	Propanoate metabolism_Homo sapiens_hsa00640	0.38594638
95	Sulfur metabolism_Homo sapiens_hsa00920	0.38158140
96	One carbon pool by folate_Homo sapiens_hsa00670	0.36783538
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34265251
98	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.34197041
99	Glioma_Homo sapiens_hsa05214	0.33057733
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32964144

RAB6C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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