ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	4.65744976
2	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.21761324
3	detection of light stimulus involved in visual perception (GO:0050908)	4.01123969
4	detection of light stimulus involved in sensory perception (GO:0050962)	4.01123969
5	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.94373191
6	cellular ketone body metabolic process (GO:0046950)	3.79863566
7	photoreceptor cell maintenance (GO:0045494)	3.69787378
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.68641417
9	kynurenine metabolic process (GO:0070189)	3.65461975
10	protein polyglutamylation (GO:0018095)	3.65438535
11	positive regulation of vascular permeability (GO:0043117)	3.62628318
12	neuron fate determination (GO:0048664)	3.59359989
13	nonmotile primary cilium assembly (GO:0035058)	3.58978102
14	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.54198526
15	negative regulation of appetite (GO:0032099)	3.49869966
16	negative regulation of response to food (GO:0032096)	3.49869966
17	indolalkylamine metabolic process (GO:0006586)	3.46520063
18	cilium or flagellum-dependent cell motility (GO:0001539)	3.45857579
19	indolalkylamine catabolic process (GO:0046218)	3.44497615
20	tryptophan catabolic process (GO:0006569)	3.44497615
21	indole-containing compound catabolic process (GO:0042436)	3.44497615
22	neuronal action potential (GO:0019228)	3.43083294
23	signal peptide processing (GO:0006465)	3.40579175
24	ketone body metabolic process (GO:1902224)	3.38949210
25	regulation of feeding behavior (GO:0060259)	3.34884907
26	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.29080771
27	protein localization to synapse (GO:0035418)	3.28934980
28	righting reflex (GO:0060013)	3.27947960
29	behavioral response to ethanol (GO:0048149)	3.24225959
30	neuron cell-cell adhesion (GO:0007158)	3.21140358
31	drinking behavior (GO:0042756)	3.20724085
32	negative regulation of mast cell activation (GO:0033004)	3.17808505
33	indole-containing compound metabolic process (GO:0042430)	3.15820666
34	serotonin metabolic process (GO:0042428)	3.12221952
35	behavioral response to nicotine (GO:0035095)	3.11524416
36	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.09665053
37	detection of calcium ion (GO:0005513)	3.07480772
38	synaptic transmission, glutamatergic (GO:0035249)	3.06637131
39	synaptic vesicle maturation (GO:0016188)	3.05650999
40	spermatid nucleus differentiation (GO:0007289)	3.04279081
41	dicarboxylic acid catabolic process (GO:0043649)	3.03635347
42	innervation (GO:0060384)	3.03528607
43	adaptation of signaling pathway (GO:0023058)	3.02607935
44	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.01669945
45	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.99078041
46	regulation of action potential (GO:0098900)	2.98454190
47	regulation of acrosome reaction (GO:0060046)	2.98114787
48	piRNA metabolic process (GO:0034587)	2.97337032
49	amine catabolic process (GO:0009310)	2.92749944
50	cellular biogenic amine catabolic process (GO:0042402)	2.92749944
51	snRNA transcription (GO:0009301)	2.90971743
52	negative regulation of cAMP-mediated signaling (GO:0043951)	2.89060664
53	reflex (GO:0060004)	2.88570274
54	glutamate receptor signaling pathway (GO:0007215)	2.88194955
55	primary amino compound metabolic process (GO:1901160)	2.86166393
56	membrane depolarization during action potential (GO:0086010)	2.86053033
57	axoneme assembly (GO:0035082)	2.84660268
58	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.82935891
59	startle response (GO:0001964)	2.80530953
60	glycosphingolipid biosynthetic process (GO:0006688)	2.80097191
61	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.80057117
62	proline transport (GO:0015824)	2.79163704
63	retinal cone cell development (GO:0046549)	2.77760752
64	synaptic vesicle exocytosis (GO:0016079)	2.75190894
65	glomerular basement membrane development (GO:0032836)	2.73014639
66	protein localization to cilium (GO:0061512)	2.71041328
67	tachykinin receptor signaling pathway (GO:0007217)	2.70830067
68	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.70213987
69	sulfation (GO:0051923)	2.69872859
70	transmission of nerve impulse (GO:0019226)	2.69864165
71	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.69352053
72	glutamate secretion (GO:0014047)	2.67817071
73	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.67723746
74	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.66570598
75	neuron-neuron synaptic transmission (GO:0007270)	2.66095123
76	opioid receptor signaling pathway (GO:0038003)	2.65126780
77	regulation of appetite (GO:0032098)	2.63803254
78	cochlea development (GO:0090102)	2.62255985
79	positive regulation of cAMP-mediated signaling (GO:0043950)	2.59075911
80	neuropeptide signaling pathway (GO:0007218)	2.57024589
81	benzene-containing compound metabolic process (GO:0042537)	2.56972322
82	neuronal action potential propagation (GO:0019227)	2.55450273
83	tryptophan metabolic process (GO:0006568)	2.55253630
84	auditory receptor cell stereocilium organization (GO:0060088)	2.51311537
85	central nervous system myelination (GO:0022010)	2.49813653
86	axon ensheathment in central nervous system (GO:0032291)	2.49813653
87	aromatic amino acid family catabolic process (GO:0009074)	2.49683427
88	aspartate family amino acid catabolic process (GO:0009068)	2.48121655
89	L-fucose catabolic process (GO:0042355)	2.46698008
90	fucose catabolic process (GO:0019317)	2.46698008
91	L-fucose metabolic process (GO:0042354)	2.46698008
92	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.45591726
93	neurotransmitter secretion (GO:0007269)	2.43461030
94	regulation of glucocorticoid secretion (GO:2000849)	2.41982060
95	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.40336573
96	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.39033041
97	establishment of protein localization to Golgi (GO:0072600)	2.38852946
98	regulation of timing of cell differentiation (GO:0048505)	2.38591237
99	action potential (GO:0001508)	2.37873504
100	photoreceptor cell development (GO:0042461)	2.36557841

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.66433226
2	VDR_22108803_ChIP-Seq_LS180_Human	3.36613169
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.99268876
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.85268960
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83024141
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71429779
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.70237622
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.65418113
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.59952921
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.45284056
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.40806977
12	P300_19829295_ChIP-Seq_ESCs_Human	2.10891755
13	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.10212722
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09788899
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.03160779
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02579780
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.99717387
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.95876232
19	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.89787702
20	FUS_26573619_Chip-Seq_HEK293_Human	1.85165144
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.83943968
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.83865340
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80663721
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79958461
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.73549000
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71172792
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.69491805
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64112093
29	AR_25329375_ChIP-Seq_VCAP_Human	1.63320183
30	STAT3_23295773_ChIP-Seq_U87_Human	1.63142662
31	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.60019365
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56769186
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55385484
34	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.55228693
35	EWS_26573619_Chip-Seq_HEK293_Human	1.54557688
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52407840
37	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.52226373
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51729778
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.51729778
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49857545
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48449743
42	TCF4_23295773_ChIP-Seq_U87_Human	1.47802859
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43832730
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42863527
45	AR_21572438_ChIP-Seq_LNCaP_Human	1.41924063
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40424850
47	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.39642806
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37543881
49	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.36544806
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35839384
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35839384
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34463265
53	DROSHA_22980978_ChIP-Seq_HELA_Human	1.32282735
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31741540
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27895538
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27895538
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27440683
58	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24140821
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22438583
60	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.20995511
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20729577
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19796745
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19783385
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17396658
65	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16817926
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16422735
67	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16305690
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16264371
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15371061
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.15100585
71	KDM2B_26808549_Chip-Seq_REH_Human	1.14243560
72	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.13698291
73	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13663327
74	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13642191
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.13444894
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.12614016
77	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12132042
78	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12090512
79	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.11234946
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10671669
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10643068
82	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10571831
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10327534
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09574725
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08351071
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08163617
87	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.07789326
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06851248
89	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.05668110
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05111929
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04796458
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04750583
93	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.04558588
94	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.04558588
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04367053
96	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.04360661
97	AHR_22903824_ChIP-Seq_MCF-7_Human	1.03696205
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02216838
99	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.02117344
100	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01295947

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.93186273
2	MP0002653_abnormal_ependyma_morphology	3.66656965
3	MP0001968_abnormal_touch/_nociception	3.16122162
4	MP0009046_muscle_twitch	2.79161627
5	MP0001501_abnormal_sleep_pattern	2.57919461
6	MP0009745_abnormal_behavioral_response	2.54629046
7	MP0005551_abnormal_eye_electrophysiolog	2.52281978
8	MP0002736_abnormal_nociception_after	2.43468965
9	MP0003880_abnormal_central_pattern	2.26595867
10	MP0002272_abnormal_nervous_system	2.24696361
11	MP0001984_abnormal_olfaction	2.24043541
12	MP0002064_seizures	2.21302985
13	MP0001486_abnormal_startle_reflex	2.20227043
14	MP0003635_abnormal_synaptic_transmissio	2.18591603
15	MP0002735_abnormal_chemical_nociception	2.17826361
16	MP0005645_abnormal_hypothalamus_physiol	2.11878044
17	MP0004859_abnormal_synaptic_plasticity	2.11420225
18	MP0002572_abnormal_emotion/affect_behav	2.10031563
19	MP0005646_abnormal_pituitary_gland	2.06577956
20	MP0005084_abnormal_gallbladder_morpholo	2.05397044
21	MP0004270_analgesia	2.04476743
22	MP0002733_abnormal_thermal_nociception	1.89140079
23	MP0000013_abnormal_adipose_tissue	1.87277256
24	MP0001970_abnormal_pain_threshold	1.85901232
25	MP0002063_abnormal_learning/memory/cond	1.81257758
26	MP0003136_yellow_coat_color	1.77616551
27	MP0003195_calcinosis	1.72568464
28	MP0005423_abnormal_somatic_nervous	1.69389221
29	MP0006072_abnormal_retinal_apoptosis	1.69177604
30	MP0001529_abnormal_vocalization	1.68589106
31	MP0000383_abnormal_hair_follicle	1.61821324
32	MP0002837_dystrophic_cardiac_calcinosis	1.61462682
33	MP0001986_abnormal_taste_sensitivity	1.57647382
34	MP0008877_abnormal_DNA_methylation	1.57260708
35	MP0003011_delayed_dark_adaptation	1.55536010
36	MP0002557_abnormal_social/conspecific_i	1.54264823
37	MP0002734_abnormal_mechanical_nocicepti	1.53227860
38	MP0005253_abnormal_eye_physiology	1.52585240
39	MP0002876_abnormal_thyroid_physiology	1.50642808
40	MP0001664_abnormal_digestion	1.50107305
41	MP0006276_abnormal_autonomic_nervous	1.45500433
42	MP0008872_abnormal_physiological_respon	1.43493289
43	MP0002638_abnormal_pupillary_reflex	1.41052991
44	MP0004043_abnormal_pH_regulation	1.39929015
45	MP0005670_abnormal_white_adipose	1.38326891
46	MP0002067_abnormal_sensory_capabilities	1.35572265
47	MP0001485_abnormal_pinna_reflex	1.34079343
48	MP0004142_abnormal_muscle_tone	1.33480594
49	MP0004742_abnormal_vestibular_system	1.29929863
50	MP0001905_abnormal_dopamine_level	1.29357857
51	MP0001440_abnormal_grooming_behavior	1.23842007
52	MP0003879_abnormal_hair_cell	1.22788317
53	MP0003633_abnormal_nervous_system	1.21800725
54	MP0002909_abnormal_adrenal_gland	1.21172771
55	MP0005386_behavior/neurological_phenoty	1.20160636
56	MP0004924_abnormal_behavior	1.20160636
57	MP0000569_abnormal_digit_pigmentation	1.19331978
58	MP0002928_abnormal_bile_duct	1.15770437
59	MP0002229_neurodegeneration	1.15247852
60	MP0000955_abnormal_spinal_cord	1.15141936
61	MP0000427_abnormal_hair_cycle	1.14823862
62	MP0003329_amyloid_beta_deposits	1.09927820
63	MP0008995_early_reproductive_senescence	1.07791298
64	MP0010386_abnormal_urinary_bladder	1.07696152
65	MP0004215_abnormal_myocardial_fiber	1.07009377
66	MP0005410_abnormal_fertilization	1.06373999
67	MP0002882_abnormal_neuron_morphology	1.05454194
68	MP0005310_abnormal_salivary_gland	1.03425393
69	MP0003631_nervous_system_phenotype	1.03216858
70	MP0010678_abnormal_skin_adnexa	1.00430123
71	MP0002102_abnormal_ear_morphology	0.99805264
72	MP0000778_abnormal_nervous_system	0.97123823
73	MP0009780_abnormal_chondrocyte_physiolo	0.91706551
74	MP0001963_abnormal_hearing_physiology	0.90592950
75	MP0000538_abnormal_urinary_bladder	0.90062778
76	MP0000026_abnormal_inner_ear	0.88938129
77	MP0002184_abnormal_innervation	0.88717405
78	MP0000467_abnormal_esophagus_morphology	0.86731975
79	MP0002752_abnormal_somatic_nervous	0.86668573
80	MP0002066_abnormal_motor_capabilities/c	0.84835157
81	MP0005499_abnormal_olfactory_system	0.84126397
82	MP0005394_taste/olfaction_phenotype	0.84126397
83	MP0003632_abnormal_nervous_system	0.80922766
84	MP0005085_abnormal_gallbladder_physiolo	0.80474609
85	MP0004147_increased_porphyrin_level	0.79159153
86	MP0000230_abnormal_systemic_arterial	0.77614180
87	MP0005195_abnormal_posterior_eye	0.77608012
88	MP0003698_abnormal_male_reproductive	0.77423679
89	MP0000015_abnormal_ear_pigmentation	0.77381576
90	MP0003122_maternal_imprinting	0.77071350
91	MP0008789_abnormal_olfactory_epithelium	0.76279047
92	MP0002069_abnormal_eating/drinking_beha	0.76258001
93	MP0004085_abnormal_heartbeat	0.75998090
94	MP0001756_abnormal_urination	0.75856287
95	MP0004811_abnormal_neuron_physiology	0.75794363
96	MP0003646_muscle_fatigue	0.73589753
97	MP0003718_maternal_effect	0.73260642
98	MP0000631_abnormal_neuroendocrine_gland	0.73229439
99	MP0001765_abnormal_ion_homeostasis	0.72950657
100	MP0002160_abnormal_reproductive_system	0.72936072

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	4.43742430
2	Gaze-evoked nystagmus (HP:0000640)	4.37273781
3	Gait imbalance (HP:0002141)	4.28248447
4	Congenital primary aphakia (HP:0007707)	4.06611275
5	Nephrogenic diabetes insipidus (HP:0009806)	3.90614321
6	Progressive cerebellar ataxia (HP:0002073)	3.86575639
7	Pancreatic cysts (HP:0001737)	3.71978692
8	Genetic anticipation (HP:0003743)	3.56102703
9	Abnormality of alanine metabolism (HP:0010916)	3.36770314
10	Hyperalaninemia (HP:0003348)	3.36770314
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.36770314
12	Dysmetric saccades (HP:0000641)	3.33120468
13	Attenuation of retinal blood vessels (HP:0007843)	3.24243523
14	Pancreatic fibrosis (HP:0100732)	3.21505821
15	Polydipsia (HP:0001959)	3.21257151
16	Abnormal drinking behavior (HP:0030082)	3.21257151
17	Genital tract atresia (HP:0001827)	3.18645756
18	Vaginal atresia (HP:0000148)	3.14258698
19	True hermaphroditism (HP:0010459)	3.05841006
20	Focal motor seizures (HP:0011153)	2.96291571
21	Febrile seizures (HP:0002373)	2.86074107
22	Large for gestational age (HP:0001520)	2.78537752
23	Limb dystonia (HP:0002451)	2.74543623
24	Congenital stationary night blindness (HP:0007642)	2.71296984
25	Abnormality of macular pigmentation (HP:0008002)	2.71054006
26	Generalized aminoaciduria (HP:0002909)	2.70393935
27	Hyperventilation (HP:0002883)	2.69627683
28	Bony spicule pigmentary retinopathy (HP:0007737)	2.67525186
29	Poor coordination (HP:0002370)	2.66968690
30	Progressive inability to walk (HP:0002505)	2.65380039
31	Focal seizures (HP:0007359)	2.62538349
32	Thyroid-stimulating hormone excess (HP:0002925)	2.54961722
33	Failure to thrive in infancy (HP:0001531)	2.54098312
34	Molar tooth sign on MRI (HP:0002419)	2.50915526
35	Abnormality of midbrain morphology (HP:0002418)	2.50915526
36	Pendular nystagmus (HP:0012043)	2.49630447
37	Polyuria (HP:0000103)	2.49552361
38	Intestinal atresia (HP:0011100)	2.48557454
39	Cystic liver disease (HP:0006706)	2.39394319
40	Broad foot (HP:0001769)	2.39029271
41	Central scotoma (HP:0000603)	2.38073012
42	Abolished electroretinogram (ERG) (HP:0000550)	2.38026335
43	Inability to walk (HP:0002540)	2.36920741
44	Renal Fanconi syndrome (HP:0001994)	2.36101624
45	Specific learning disability (HP:0001328)	2.32363856
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.27040577
47	Absent/shortened dynein arms (HP:0200106)	2.27040577
48	Lissencephaly (HP:0001339)	2.26527664
49	Absent speech (HP:0001344)	2.26323691
50	Short foot (HP:0001773)	2.24844250
51	Epileptic encephalopathy (HP:0200134)	2.24163612
52	Aplasia/Hypoplasia of the lens (HP:0008063)	2.24080474
53	Hypophosphatemic rickets (HP:0004912)	2.21606601
54	Increased corneal curvature (HP:0100692)	2.20988564
55	Keratoconus (HP:0000563)	2.20988564
56	Ketoacidosis (HP:0001993)	2.20950542
57	Abnormality of the renal cortex (HP:0011035)	2.17434789
58	Left ventricular hypertrophy (HP:0001712)	2.16655878
59	Decreased testicular size (HP:0008734)	2.14588954
60	Sclerocornea (HP:0000647)	2.14566738
61	Stomach cancer (HP:0012126)	2.14352314
62	Broad-based gait (HP:0002136)	2.11384777
63	Type II lissencephaly (HP:0007260)	2.10873033
64	Epileptiform EEG discharges (HP:0011182)	2.09480045
65	Retinitis pigmentosa (HP:0000510)	2.06776941
66	Dialeptic seizures (HP:0011146)	2.06200298
67	Amelogenesis imperfecta (HP:0000705)	2.06156413
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.02659518
69	Abnormal urine output (HP:0012590)	2.00268329
70	Hypothermia (HP:0002045)	1.99585429
71	Pancreatic islet-cell hyperplasia (HP:0004510)	1.98895155
72	Generalized tonic-clonic seizures (HP:0002069)	1.98091712
73	EEG with generalized epileptiform discharges (HP:0011198)	1.97690640
74	Furrowed tongue (HP:0000221)	1.95846248
75	Atonic seizures (HP:0010819)	1.95758575
76	Hypsarrhythmia (HP:0002521)	1.95202347
77	Congenital sensorineural hearing impairment (HP:0008527)	1.93451124
78	Delayed puberty (HP:0000823)	1.93078699
79	Dysdiadochokinesis (HP:0002075)	1.91748624
80	Ankle clonus (HP:0011448)	1.91431801
81	Absence seizures (HP:0002121)	1.90956778
82	Bilateral sensorineural hearing impairment (HP:0008619)	1.90561085
83	Optic nerve hypoplasia (HP:0000609)	1.87601927
84	Hemiparesis (HP:0001269)	1.86583246
85	Postaxial hand polydactyly (HP:0001162)	1.83757565
86	Chronic hepatic failure (HP:0100626)	1.81264215
87	Myokymia (HP:0002411)	1.81253535
88	Ketosis (HP:0001946)	1.81148703
89	Horizontal nystagmus (HP:0000666)	1.80135611
90	Abnormality of renal resorption (HP:0011038)	1.77472581
91	Polyphagia (HP:0002591)	1.76006222
92	Methylmalonic acidemia (HP:0002912)	1.74643345
93	Congenital hepatic fibrosis (HP:0002612)	1.74480819
94	Nephronophthisis (HP:0000090)	1.74438934
95	Abnormal ciliary motility (HP:0012262)	1.74075777
96	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73189237
97	Renal cortical cysts (HP:0000803)	1.71711594
98	Truncal ataxia (HP:0002078)	1.71151222
99	Prominent supraorbital ridges (HP:0000336)	1.70967468
100	Abnormality of renal excretion (HP:0011036)	1.70316455

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.33963448
2	INSRR	3.63292805
3	MAP4K2	3.43531937
4	ADRBK2	2.97533202
5	MAP3K4	2.50529449
6	FLT3	2.40500460
7	PDK2	2.38322103
8	PINK1	2.11242863
9	TAF1	2.07310644
10	ACVR1B	2.04528041
11	WNK3	1.99632014
12	BMPR1B	1.98941788
13	MAPK13	1.84332315
14	TAOK3	1.81375904
15	PRKD3	1.77670166
16	CASK	1.76052492
17	NTRK3	1.72802631
18	OXSR1	1.71115023
19	MARK1	1.62748562
20	DAPK2	1.61311316
21	GRK1	1.61092353
22	MAP2K7	1.59135695
23	BCKDK	1.55149020
24	EPHA4	1.50695220
25	IKBKE	1.36892880
26	TRIM28	1.24443509
27	STK39	1.19811508
28	BLK	1.19056212
29	PRKCG	1.10653242
30	CAMKK2	1.10464825
31	SGK2	1.05747660
32	CSNK1G2	1.05159449
33	NTRK2	1.03259410
34	CSNK1G3	1.01332452
35	TNK2	1.01097497
36	PRKCE	1.00654451
37	ERBB3	1.00508887
38	MUSK	1.00494632
39	SCYL2	0.99023833
40	BCR	0.98755747
41	PRKG2	0.95356054
42	MST4	0.91916515
43	CSNK1A1L	0.90610492
44	NUAK1	0.89550902
45	CSNK1G1	0.87021684
46	ADRBK1	0.86805289
47	FER	0.86334651
48	KIT	0.85826677
49	PAK3	0.85362310
50	PIK3CG	0.83268691
51	CAMK2A	0.82181691
52	SIK2	0.81779386
53	GRK5	0.81547593
54	PLK2	0.80184394
55	PKN1	0.79690491
56	SGK223	0.79220068
57	SGK494	0.79220068
58	MAPKAPK3	0.79060297
59	CSF1R	0.76800053
60	TEC	0.76002243
61	DAPK1	0.73896014
62	MAP2K4	0.72830995
63	PHKG1	0.67845947
64	PHKG2	0.67845947
65	FGFR2	0.65264011
66	PRKCH	0.61023558
67	STK38L	0.57213566
68	CAMK1	0.56040605
69	CAMK2D	0.54975841
70	PAK6	0.54655799
71	AKT3	0.53343586
72	PTK2B	0.53188236
73	PRKACA	0.52222579
74	MAPKAPK5	0.51110344
75	CAMK2B	0.49326098
76	SGK3	0.49319407
77	WNK4	0.48692029
78	BMPR2	0.47994050
79	CHUK	0.46416670
80	PRKCZ	0.44941673
81	LIMK1	0.42954656
82	ZAK	0.42660204
83	EPHA3	0.42650416
84	PRKAA2	0.41318631
85	MINK1	0.39987483
86	PDK1	0.39938975
87	CDK5	0.36582599
88	PRKCA	0.35873788
89	CSNK1A1	0.35462772
90	CSNK1D	0.34458843
91	DYRK2	0.34060411
92	DYRK1A	0.34049205
93	PRKAA1	0.33922754
94	ERBB4	0.32323457
95	IKBKB	0.30648193
96	MYLK	0.29528246
97	PRKCI	0.29175406
98	TXK	0.29012983
99	PRKACG	0.28129459
100	RPS6KA3	0.27745026

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.47250038
2	Butanoate metabolism_Homo sapiens_hsa00650	2.51406993
3	Taste transduction_Homo sapiens_hsa04742	2.46474831
4	Phototransduction_Homo sapiens_hsa04744	2.43426217
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.42771399
6	GABAergic synapse_Homo sapiens_hsa04727	2.40406512
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17986365
8	Morphine addiction_Homo sapiens_hsa05032	2.14592951
9	Circadian entrainment_Homo sapiens_hsa04713	2.10784515
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.99343141
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.99322623
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.94335368
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.93940530
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.90999639
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.90764515
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.89657327
17	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.86310003
18	Olfactory transduction_Homo sapiens_hsa04740	1.85275754
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84034105
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.83854387
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.79506338
22	Salivary secretion_Homo sapiens_hsa04970	1.77814498
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.73461488
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.64546617
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.58197432
26	ABC transporters_Homo sapiens_hsa02010	1.56060439
27	Propanoate metabolism_Homo sapiens_hsa00640	1.48062806
28	Insulin secretion_Homo sapiens_hsa04911	1.41745179
29	Renin secretion_Homo sapiens_hsa04924	1.38555125
30	Serotonergic synapse_Homo sapiens_hsa04726	1.37838684
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.29945448
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.29914297
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28854785
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.27495832
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.27092706
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26830022
37	Histidine metabolism_Homo sapiens_hsa00340	1.20896793
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.16843502
39	Cocaine addiction_Homo sapiens_hsa05030	1.13114439
40	Amphetamine addiction_Homo sapiens_hsa05031	1.07645675
41	Long-term depression_Homo sapiens_hsa04730	1.05665537
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.04130250
43	Calcium signaling pathway_Homo sapiens_hsa04020	1.02268847
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.99140621
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.98193191
46	Retinol metabolism_Homo sapiens_hsa00830	0.95033472
47	Regulation of autophagy_Homo sapiens_hsa04140	0.93169951
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93024922
49	Gastric acid secretion_Homo sapiens_hsa04971	0.90784182
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.90763735
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87855347
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83420180
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.81894440
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81575337
55	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.80274676
56	Cholinergic synapse_Homo sapiens_hsa04725	0.79700828
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76231345
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70314311
59	Peroxisome_Homo sapiens_hsa04146	0.70238867
60	Protein export_Homo sapiens_hsa03060	0.70141825
61	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.69929241
62	Basal transcription factors_Homo sapiens_hsa03022	0.68756887
63	Oxidative phosphorylation_Homo sapiens_hsa00190	0.67061508
64	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66654030
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65115171
66	Sphingolipid metabolism_Homo sapiens_hsa00600	0.63798069
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.62697143
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61673171
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.61638500
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.61320859
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.61193033
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.59001392
73	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56892637
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55537042
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55189245
76	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.54959158
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54381107
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.53737931
79	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.50310753
80	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.50002276
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.49389146
82	Fatty acid degradation_Homo sapiens_hsa00071	0.48740319
83	Metabolic pathways_Homo sapiens_hsa01100	0.48733434
84	Pancreatic secretion_Homo sapiens_hsa04972	0.48371481
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48204754
86	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47536251
87	Bile secretion_Homo sapiens_hsa04976	0.46647539
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44307851
89	Mineral absorption_Homo sapiens_hsa04978	0.43295981
90	Circadian rhythm_Homo sapiens_hsa04710	0.42193218
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42153408
92	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.40864038
93	PPAR signaling pathway_Homo sapiens_hsa03320	0.39569479
94	Asthma_Homo sapiens_hsa05310	0.39387919
95	Parkinsons disease_Homo sapiens_hsa05012	0.38226113
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.36207798
97	Caffeine metabolism_Homo sapiens_hsa00232	0.36171760
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.35237001
99	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35057302
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.34141781

RAB6C-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »