RAB8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44016064
2neutrophil activation involved in immune response (GO:0002283)4.92721973
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.91524045
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.91524045
5modulation by symbiont of host immune response (GO:0052553)4.91524045
6positive regulation by symbiont of host defense response (GO:0052509)4.91524045
7modulation by symbiont of host defense response (GO:0052031)4.91524045
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.91524045
9positive regulation of interferon-alpha production (GO:0032727)4.55437372
10negative regulation of interleukin-12 production (GO:0032695)4.45332356
11regulation of interferon-alpha production (GO:0032647)4.41458631
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.33935569
13regulation of gamma-delta T cell activation (GO:0046643)4.31137687
14response to interleukin-15 (GO:0070672)4.24163207
15cellular response to interleukin-15 (GO:0071350)4.15388637
16response to peptidoglycan (GO:0032494)4.11392815
17regulation of T-helper 1 cell differentiation (GO:0045625)4.10433089
18antigen processing and presentation of endogenous antigen (GO:0019883)4.04950663
19regulation of activation of Janus kinase activity (GO:0010533)4.03585227
20detection of molecule of bacterial origin (GO:0032490)3.95010213
21granulocyte activation (GO:0036230)3.94584631
22neutrophil activation (GO:0042119)3.93005375
23positive regulation of gamma-delta T cell activation (GO:0046645)3.92791409
24regulation of gamma-delta T cell differentiation (GO:0045586)3.88610053
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.85323213
26regulation of interferon-beta biosynthetic process (GO:0045357)3.84253377
27myeloid dendritic cell differentiation (GO:0043011)3.84135573
28regulation of regulatory T cell differentiation (GO:0045589)3.81160566
29cellular extravasation (GO:0045123)3.80757911
30positive regulation of alpha-beta T cell proliferation (GO:0046641)3.80059638
31positive regulation of interleukin-12 production (GO:0032735)3.79547242
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78851432
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78851432
34immunoglobulin mediated immune response (GO:0016064)3.74735331
35regulation of isotype switching to IgG isotypes (GO:0048302)3.73327386
36interferon-gamma production (GO:0032609)3.72947158
37regulation of alpha-beta T cell proliferation (GO:0046640)3.70858445
38myeloid dendritic cell activation (GO:0001773)3.70808468
39positive regulation of antigen processing and presentation (GO:0002579)3.66188711
40natural killer cell mediated cytotoxicity (GO:0042267)3.61968904
41natural killer cell mediated immunity (GO:0002228)3.61968904
42response to muramyl dipeptide (GO:0032495)3.61917709
43T-helper 1 type immune response (GO:0042088)3.61191919
44detection of other organism (GO:0098543)3.61177695
45positive regulation of natural killer cell differentiation (GO:0032825)3.58714535
46neutrophil mediated immunity (GO:0002446)3.55188802
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.54157222
48negative regulation of T cell mediated immunity (GO:0002710)3.53718561
49macrophage activation involved in immune response (GO:0002281)3.52934972
50NIK/NF-kappaB signaling (GO:0038061)3.51684700
51positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.50406452
52positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.48176704
53positive regulation of T-helper cell differentiation (GO:0045624)3.47511823
54cellular response to type I interferon (GO:0071357)3.47164759
55type I interferon signaling pathway (GO:0060337)3.47164759
56response to type I interferon (GO:0034340)3.45287495
57regulation of B cell receptor signaling pathway (GO:0050855)3.44620383
58leukocyte aggregation (GO:0070486)3.43365695
59negative thymic T cell selection (GO:0045060)3.43155855
60response to host immune response (GO:0052572)3.42792398
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42792398
62activated T cell proliferation (GO:0050798)3.42062715
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.39186283
64lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38235534
65positive regulation of interleukin-2 production (GO:0032743)3.34332071
66negative regulation of interleukin-17 production (GO:0032700)3.34265670
67tolerance induction (GO:0002507)3.33763986
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31720262
69detection of external biotic stimulus (GO:0098581)3.31668053
70negative T cell selection (GO:0043383)3.30145998
71regulation of tolerance induction (GO:0002643)3.30107081
72defense response to protozoan (GO:0042832)3.27033886
73respiratory burst (GO:0045730)3.27030354
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.25413443
75positive regulation of type 2 immune response (GO:0002830)3.24840616
76myeloid leukocyte mediated immunity (GO:0002444)3.24506166
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24228640
78positive T cell selection (GO:0043368)3.23299385
79interferon-gamma-mediated signaling pathway (GO:0060333)3.23245748
80positive regulation of interleukin-17 production (GO:0032740)3.22990688
81regulation of interleukin-12 production (GO:0032655)3.22729501
82positive regulation of interferon-beta production (GO:0032728)3.22172248
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.21455435
84regulation of natural killer cell mediated immunity (GO:0002715)3.21455435
85myeloid cell activation involved in immune response (GO:0002275)3.20889882
86regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.19706704
87T cell migration (GO:0072678)3.19554548
88regulation of T-helper cell differentiation (GO:0045622)3.18725221
89dendritic cell chemotaxis (GO:0002407)3.16212765
90regulation of antigen processing and presentation (GO:0002577)3.13731929
91regulation of interleukin-17 production (GO:0032660)3.13311261
92positive regulation of chemokine biosynthetic process (GO:0045080)3.12563174
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11438445
94response to host (GO:0075136)3.11438445
95response to host defenses (GO:0052200)3.11438445
96detection of bacterium (GO:0016045)3.11343998
97dendritic cell migration (GO:0036336)3.11252363
98regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.10777705
99B cell receptor signaling pathway (GO:0050853)3.08538776
100microglial cell activation (GO:0001774)3.07659499
101regulation of RIG-I signaling pathway (GO:0039535)3.07464689
102dendritic cell differentiation (GO:0097028)3.07323237
103regulation of T-helper 1 type immune response (GO:0002825)3.05935930
104regulation of interleukin-2 biosynthetic process (GO:0045076)3.05664171
105positive regulation of T-helper 1 type immune response (GO:0002827)3.05253281
106cellular response to zinc ion (GO:0071294)3.02539742
107regulation of hypersensitivity (GO:0002883)3.02215252
108monocyte chemotaxis (GO:0002548)3.02202100
109positive regulation of cytokine biosynthetic process (GO:0042108)3.00583492
110negative regulation of cell killing (GO:0031342)3.00396202
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00396202
112positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.00008790
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99966707
114positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.99687996
115regulation of T-helper 2 cell differentiation (GO:0045628)2.99564110
116regulation of T cell tolerance induction (GO:0002664)2.99192991
117regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.98992804
118B cell mediated immunity (GO:0019724)2.98341881
119detection of biotic stimulus (GO:0009595)2.97732939
120regulation of immunoglobulin secretion (GO:0051023)2.97435129
121cellular response to interferon-beta (GO:0035458)2.95822184
122regulation of B cell differentiation (GO:0045577)2.95463060
123positive regulation of isotype switching (GO:0045830)2.95370865
124positive regulation of tolerance induction (GO:0002645)2.94846858
125germinal center formation (GO:0002467)2.93829552
126positive regulation of interleukin-10 production (GO:0032733)2.93436558
127positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93171251
128regulation of chronic inflammatory response (GO:0002676)2.92891116
129response to protozoan (GO:0001562)2.92356855
130myeloid leukocyte activation (GO:0002274)2.90793735
131positive thymic T cell selection (GO:0045059)2.90387673
132T cell selection (GO:0045058)2.90099168
133leukocyte mediated cytotoxicity (GO:0001909)2.89809962
134regulation of memory T cell differentiation (GO:0043380)2.89612623
135negative regulation of leukocyte mediated immunity (GO:0002704)2.89172164
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.87749696
137positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87589012
138macrophage activation (GO:0042116)2.87159815
139positive regulation of mast cell activation (GO:0033005)2.85335595
140positive regulation of interleukin-1 beta secretion (GO:0050718)2.84395083
141negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84352165
142production of molecular mediator involved in inflammatory response (GO:0002532)2.84172956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.72389931
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.62735146
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.89337589
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.84250572
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.55271876
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28452541
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.22323783
8IRF8_27001747_Chip-Seq_BMDM_Mouse4.21948032
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.85475781
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.59443941
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.51618196
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49386539
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.06560236
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.06471904
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.03897880
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.99126723
17* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96461128
18* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.90530920
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41217311
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40892305
21RUNX_20019798_ChIP-Seq_JUKART_Human2.34741662
22* MYB_26560356_Chip-Seq_TH2_Human2.29244968
23* SPI1_23547873_ChIP-Seq_NB4_Human2.14698555
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13108965
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03788912
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.99458285
27* MAF_26560356_Chip-Seq_TH1_Human1.89274351
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88303329
29SCL_19346495_ChIP-Seq_HPC-7_Human1.85671686
30PU_27001747_Chip-Seq_BMDM_Mouse1.79373634
31* MYB_26560356_Chip-Seq_TH1_Human1.79157958
32VDR_24787735_ChIP-Seq_THP-1_Human1.78020896
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76661821
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71848786
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70010438
36VDR_24763502_ChIP-Seq_THP-1_Human1.68578610
37TAF15_26573619_Chip-Seq_HEK293_Human1.67009059
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.65341959
39SPI1_23127762_ChIP-Seq_K562_Human1.64449084
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63671527
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61442364
42* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61286371
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55760636
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55414387
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52142829
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51404466
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.48842380
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47619124
49E2F7_22180533_ChIP-Seq_HELA_Human1.47121936
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45981883
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42410751
52* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41640517
53VDR_21846776_ChIP-Seq_THP-1_Human1.34095949
54* GATA3_26560356_Chip-Seq_TH2_Human1.32299390
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31543191
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.27952399
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26843992
58IGF1R_20145208_ChIP-Seq_DFB_Human1.26568991
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21143001
60* UTX_26944678_Chip-Seq_JUKART_Human1.19154593
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18262832
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.16177271
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15729716
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14439781
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14116167
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11914992
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11088301
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.09509543
69TCF7_22412390_ChIP-Seq_EML_Mouse1.08226595
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.07688242
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06297761
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04310865
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03803724
74IRF1_19129219_ChIP-ChIP_H3396_Human1.03728576
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01640246
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00675789
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00547093
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00402132
79GATA1_22025678_ChIP-Seq_K562_Human1.00152641
80* MAF_26560356_Chip-Seq_TH2_Human0.98664580
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98662410
82VDR_23849224_ChIP-Seq_CD4+_Human0.98266866
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96906363
84MYC_22102868_ChIP-Seq_BL_Human0.95148531
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93323871
86TP63_17297297_ChIP-ChIP_HaCaT_Human0.93247331
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92527921
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91983303
89ZNF274_21170338_ChIP-Seq_K562_Hela0.91547649
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91254030
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.90897886
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89555761
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88194510
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.87474343
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87225000
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87135227
97ELK1_19687146_ChIP-ChIP_HELA_Human0.86989016
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.86367258
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.85631436
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.85359830
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85320740
102SMRT_27268052_Chip-Seq_Bcells_Human0.84968293
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84380811
104FLI1_21867929_ChIP-Seq_TH2_Mouse0.82778826
105CMYC_18555785_Chip-Seq_ESCs_Mouse0.82713666
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.80996507
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80306560
108P300_19829295_ChIP-Seq_ESCs_Human0.78410030
109GATA3_26560356_Chip-Seq_TH1_Human0.78387624
110CRX_20693478_ChIP-Seq_RETINA_Mouse0.78145615
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77629040
112* SALL4_22934838_ChIP-ChIP_CD34+_Human0.77595935
113* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77548361
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77108735
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75685177
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75685177
117EGR1_19032775_ChIP-ChIP_M12_Human0.73828288
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73643475
119HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73387180
120* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72010811
121TFEB_21752829_ChIP-Seq_HELA_Human0.71846043
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68707500
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68697698
124KDM2B_26808549_Chip-Seq_DND41_Human0.67946249
125KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.67928002
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67896683
127GATA2_19941826_ChIP-Seq_K562_Human0.67405829
128* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67304402
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.66846508
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.65519168
131JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64408127
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62009940
133GATA1_19941826_ChIP-Seq_K562_Human0.61033240
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.60844512
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59702614
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.58808621
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58239699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.16942151
2MP0009785_altered_susceptibility_to3.75806067
3MP0002148_abnormal_hypersensitivity_rea3.69391995
4MP0003436_decreased_susceptibility_to3.59569819
5MP0005671_abnormal_response_to3.53715750
6MP0005000_abnormal_immune_tolerance3.36419001
7MP0000685_abnormal_immune_system3.32585975
8MP0001790_abnormal_immune_system3.20893122
9MP0005387_immune_system_phenotype3.20893122
10MP0006082_CNS_inflammation3.11685988
11MP0003303_peritoneal_inflammation3.04684921
12MP0002419_abnormal_innate_immunity2.98465466
13MP0005025_abnormal_response_to2.95460933
14MP0002452_abnormal_antigen_presenting2.84129796
15MP0001800_abnormal_humoral_immune2.81417823
16MP0002723_abnormal_immune_serum2.73392856
17MP0004510_myositis2.68176054
18MP0003724_increased_susceptibility_to2.65994058
19MP0001819_abnormal_immune_cell2.54811147
20MP0002420_abnormal_adaptive_immunity2.50677216
21MP0002006_tumorigenesis2.26167510
22MP0002405_respiratory_system_inflammati2.12928173
23MP0002166_altered_tumor_susceptibility2.01799792
24MP0002398_abnormal_bone_marrow1.95484495
25MP0001853_heart_inflammation1.94040988
26MP0005310_abnormal_salivary_gland1.93838405
27MP0005464_abnormal_platelet_physiology1.93769403
28MP0000716_abnormal_immune_system1.92702015
29MP0004947_skin_inflammation1.86914022
30MP0003221_abnormal_cardiomyocyte_apopto1.82926540
31MP0001845_abnormal_inflammatory_respons1.81497719
32MP0005058_abnormal_lysosome_morphology1.81367101
33MP0003763_abnormal_thymus_physiology1.80929577
34MP0001533_abnormal_skeleton_physiology1.80456489
35MP0003448_altered_tumor_morphology1.79276827
36MP0009333_abnormal_splenocyte_physiolog1.73951195
37MP0010155_abnormal_intestine_physiology1.71727989
38MP0009764_decreased_sensitivity_to1.63758411
39MP0003300_gastrointestinal_ulcer1.57388176
40MP0000569_abnormal_digit_pigmentation1.55064352
41MP0008260_abnormal_autophagy1.54988510
42MP0002429_abnormal_blood_cell1.54547796
43MP0002138_abnormal_hepatobiliary_system1.51524927
44MP0000689_abnormal_spleen_morphology1.50513922
45MP0002722_abnormal_immune_system1.47853164
46MP0000858_altered_metastatic_potential1.47199357
47MP0005397_hematopoietic_system_phenotyp1.43918802
48MP0001545_abnormal_hematopoietic_system1.43918802
49MP0008469_abnormal_protein_level1.41830265
50MP0006054_spinal_hemorrhage1.41204183
51MP0001348_abnormal_lacrimal_gland1.32035937
52MP0004883_abnormal_blood_vessel1.30034973
53MP0009278_abnormal_bone_marrow1.29644150
54MP0002998_abnormal_bone_remodeling1.26372407
55MP0003075_altered_response_to1.25928572
56MP0003172_abnormal_lysosome_physiology1.25231337
57MP0000343_altered_response_to1.23473775
58MP0001873_stomach_inflammation1.22807675
59MP0002163_abnormal_gland_morphology1.20568119
60MP0005076_abnormal_cell_differentiation1.16316882
61MP0002277_abnormal_respiratory_mucosa1.14365299
62MP0004808_abnormal_hematopoietic_stem1.12489102
63MP0002933_joint_inflammation1.09468413
64MP0000703_abnormal_thymus_morphology1.08104416
65MP0003787_abnormal_imprinting1.06571305
66MP0010307_abnormal_tumor_latency1.04729032
67MP0002254_reproductive_system_inflammat1.04484689
68MP0002396_abnormal_hematopoietic_system1.01504550
69MP0005451_abnormal_body_composition1.01128608
70MP0003191_abnormal_cellular_cholesterol0.99198831
71MP0005166_decreased_susceptibility_to0.95855334
72MP0005248_abnormal_Harderian_gland0.92956313
73MP0001851_eye_inflammation0.92476128
74MP0000465_gastrointestinal_hemorrhage0.90315100
75MP0009765_abnormal_xenobiotic_induced0.88952312
76MP0000604_amyloidosis0.86990668
77MP0010352_gastrointestinal_tract_polyps0.86552390
78MP0005390_skeleton_phenotype0.86197981
79MP0000490_abnormal_crypts_of0.85631001
80MP0003866_abnormal_defecation0.84941353
81MP0005174_abnormal_tail_pigmentation0.83754360
82MP0009763_increased_sensitivity_to0.82728962
83MP0003453_abnormal_keratinocyte_physiol0.82593253
84MP0003091_abnormal_cell_migration0.82366365
85MP0005167_abnormal_blood-brain_barrier0.81318913
86MP0003183_abnormal_peptide_metabolism0.79142038
87MP0008057_abnormal_DNA_replication0.78747596
88MP0003828_pulmonary_edema0.78689453
89MP0002877_abnormal_melanocyte_morpholog0.76749132
90MP0002102_abnormal_ear_morphology0.74418032
91MP0003566_abnormal_cell_adhesion0.74178857
92MP0004782_abnormal_surfactant_physiolog0.73726115
93MP0000249_abnormal_blood_vessel0.70813105
94MP0003690_abnormal_glial_cell0.70590046
95MP0001663_abnormal_digestive_system0.69078506
96MP0002332_abnormal_exercise_endurance0.69061670
97MP0003656_abnormal_erythrocyte_physiolo0.67178247
98MP0001346_abnormal_lacrimal_gland0.65347162
99MP0008004_abnormal_stomach_pH0.63527166
100MP0000371_diluted_coat_color0.63192295
101MP0005164_abnormal_response_to0.62919976
102MP0002133_abnormal_respiratory_system0.62576751
103MP0005388_respiratory_system_phenotype0.62576751
104MP0002009_preneoplasia0.60829689
105MP0003795_abnormal_bone_structure0.58811325
106MP0002019_abnormal_tumor_incidence0.58703467
107MP0000015_abnormal_ear_pigmentation0.56895069
108MP0004381_abnormal_hair_follicle0.56179582
109MP0005075_abnormal_melanosome_morpholog0.56111860
110MP0001881_abnormal_mammary_gland0.55295708
111MP0000767_abnormal_smooth_muscle0.53162908
112MP0000920_abnormal_myelination0.53082524
113MP0001915_intracranial_hemorrhage0.52638750
114MP0005394_taste/olfaction_phenotype0.52296135
115MP0005499_abnormal_olfactory_system0.52296135
116MP0003045_fibrosis0.51744955
117MP0000627_abnormal_mammary_gland0.51467001
118MP0003186_abnormal_redox_activity0.49524774
119MP0004484_altered_response_of0.49097471
120MP0003329_amyloid_beta_deposits0.47723988

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.48665219
2Recurrent abscess formation (HP:0002722)6.29617809
3Recurrent bacterial skin infections (HP:0005406)5.76141092
4Optic neuritis (HP:0100653)5.05988040
5Retrobulbar optic neuritis (HP:0100654)5.05988040
6Myositis (HP:0100614)4.92604100
7Orchitis (HP:0100796)4.80543538
8Recurrent gram-negative bacterial infections (HP:0005420)4.62221112
9Mediastinal lymphadenopathy (HP:0100721)4.62073362
10Elevated erythrocyte sedimentation rate (HP:0003565)4.51203377
11Abnormality of macrophages (HP:0004311)4.36727825
12Autoimmune thrombocytopenia (HP:0001973)4.27203616
13Recurrent fungal infections (HP:0002841)4.24822280
14Stomatitis (HP:0010280)4.07965129
15Increased IgM level (HP:0003496)4.00307177
16Vasculitis (HP:0002633)4.00186093
17Chronic obstructive pulmonary disease (HP:0006510)3.90330354
18Obstructive lung disease (HP:0006536)3.90330354
19Recurrent skin infections (HP:0001581)3.73394103
20Recurrent viral infections (HP:0004429)3.71521681
21Gastrointestinal infarctions (HP:0005244)3.54528674
22Gingivitis (HP:0000230)3.47209368
23Chronic otitis media (HP:0000389)3.42730825
24Increased cerebral lipofuscin (HP:0011813)3.41132935
25Pulmonary infiltrates (HP:0002113)3.33132007
26Arterial thrombosis (HP:0004420)3.31661201
27Vacuolated lymphocytes (HP:0001922)3.30095309
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.28726588
29Abnormality of T cell number (HP:0011839)3.22764849
30Basal ganglia calcification (HP:0002135)3.17394680
31Keratoconjunctivitis sicca (HP:0001097)3.13466751
32Chronic mucocutaneous candidiasis (HP:0002728)3.10635832
33Recurrent cutaneous fungal infections (HP:0011370)3.10635832
34Meningitis (HP:0001287)3.03668369
35Hemoptysis (HP:0002105)3.02770615
36Periodontitis (HP:0000704)3.02708667
37Amyotrophic lateral sclerosis (HP:0007354)3.01158985
38Systemic lupus erythematosus (HP:0002725)3.00371524
39Hypergammaglobulinemia (HP:0010702)2.97656435
40Prostate neoplasm (HP:0100787)2.92676395
41Leukocytosis (HP:0001974)2.92598774
42Cellulitis (HP:0100658)2.88799749
43Pustule (HP:0200039)2.88034302
44Keratoconjunctivitis (HP:0001096)2.87937434
45T lymphocytopenia (HP:0005403)2.83236508
46Combined immunodeficiency (HP:0005387)2.81271648
47Eosinophilia (HP:0001880)2.71035987
48Interstitial pulmonary disease (HP:0006530)2.67684332
49Urticaria (HP:0001025)2.58399850
50Thick nail (HP:0001805)2.56153197
51Autoimmune hemolytic anemia (HP:0001890)2.55838584
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.54111057
53Disinhibition (HP:0000734)2.53458454
54Neoplasm of the tracheobronchial system (HP:0100552)2.53268312
55Abnormality of the prostate (HP:0008775)2.49392398
56Abnormality of glycolipid metabolism (HP:0010969)2.49181662
57Abnormality of liposaccharide metabolism (HP:0010968)2.49181662
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.49181662
59Nasal polyposis (HP:0100582)2.47178263
60Abnormality of T cells (HP:0002843)2.46770398
61Recurrent pneumonia (HP:0006532)2.45120784
62Gingival bleeding (HP:0000225)2.42720322
63Osteomyelitis (HP:0002754)2.42452890
64Recurrent bronchitis (HP:0002837)2.39471726
65Petechiae (HP:0000967)2.38308088
66Spontaneous hematomas (HP:0007420)2.37881277
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37511635
68Chest pain (HP:0100749)2.37084282
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.36922969
70Osteolytic defects of the hand bones (HP:0009699)2.36922969
71Thrombocytosis (HP:0001894)2.35427285
72Gangrene (HP:0100758)2.34006563
73Abnormality of eosinophils (HP:0001879)2.32240844
74Tetraparesis (HP:0002273)2.31508141
75Stomach cancer (HP:0012126)2.31395241
76Abnormality of the pleura (HP:0002103)2.29548793
77Myocardial infarction (HP:0001658)2.28240796
78IgA deficiency (HP:0002720)2.27805059
79Granulocytopenia (HP:0001913)2.26122192
80Alveolar cell carcinoma (HP:0006519)2.24552633
81IgG deficiency (HP:0004315)2.22967435
82Abnormality of B cell number (HP:0010975)2.22625376
83Abnormality of the pericardium (HP:0001697)2.22623286
84Axonal loss (HP:0003447)2.21674191
85Encephalitis (HP:0002383)2.21630592
86Anorexia (HP:0002039)2.20283436
87Papillary thyroid carcinoma (HP:0002895)2.17382105
88Increased IgE level (HP:0003212)2.17357666
89Porencephaly (HP:0002132)2.16973351
90Abnormality of the nasal mucosa (HP:0000433)2.16901359
91Peripheral hypomyelination (HP:0007182)2.16130431
92Joint swelling (HP:0001386)2.15418274
93Thyroiditis (HP:0100646)2.14933264
94Recurrent lower respiratory tract infections (HP:0002783)2.14258444
95Abnormality of T cell physiology (HP:0011840)2.13648830
96Subacute progressive viral hepatitis (HP:0006572)2.13474409
97IgM deficiency (HP:0002850)2.12496959
98B lymphocytopenia (HP:0010976)2.12176580
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.11197103
100Arthralgia (HP:0002829)2.09095156
101Viral hepatitis (HP:0006562)2.06024737
102Chronic diarrhea (HP:0002028)2.03787261
103Loss of speech (HP:0002371)2.03698016
104Keratitis (HP:0000491)2.03123571
105Polyneuropathy (HP:0001271)2.01944856
106Sepsis (HP:0100806)2.00575147
107Lymphopenia (HP:0001888)2.00200975
108Skin ulcer (HP:0200042)1.99941557
109Hematochezia (HP:0002573)1.99627160
110Premature loss of primary teeth (HP:0006323)1.98944779
111Pulmonary embolism (HP:0002204)1.96072520
112Severe combined immunodeficiency (HP:0004430)1.95890191
113Amaurosis fugax (HP:0100576)1.95655394
114Panhypogammaglobulinemia (HP:0003139)1.95330950
115Lymphoma (HP:0002665)1.94422088
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89801418
117Cortical dysplasia (HP:0002539)1.88781485
118Inflammation of the large intestine (HP:0002037)1.82219925
119Glomerulopathy (HP:0100820)1.79611173
120Abnormality of the endocardium (HP:0004306)1.79453166
121Epistaxis (HP:0000421)1.77261558
122Recurrent sinusitis (HP:0011108)1.74370552
123Agammaglobulinemia (HP:0004432)1.74049123
124Large earlobe (HP:0009748)1.71095985
125Episodic fever (HP:0001954)1.67654963
126Peritonitis (HP:0002586)1.66739222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.09939208
2TXK3.81240149
3MAP4K13.48985119
4TBK13.39851432
5JAK33.26084359
6BLK3.02661050
7TYK22.99343553
8RIPK42.91660520
9IRAK42.90086804
10IKBKB2.87294682
11IKBKE2.59615667
12JAK12.22937365
13PBK2.14769336
14MAP3K132.02644313
15CHUK2.02453949
16KIT1.97506942
17ZAP701.90458814
18IRAK31.85345967
19PRPF4B1.84944174
20PIM21.81314939
21CAMKK21.77091719
22SYK1.74602910
23EPHB11.62037350
24MAP3K41.54534164
25TEC1.48588830
26HCK1.47853057
27FGFR31.46999310
28BTK1.44169695
29STK101.43312137
30TRIM281.41392188
31CSK1.41216276
32BRD41.41066727
33ITK1.37044700
34CSF1R1.36721675
35PIM11.36683185
36BMPR21.35498634
37KSR11.33506380
38LCK1.32843047
39NEK91.30912793
40EPHA31.29066141
41JAK21.18768381
42MST41.17298270
43FGFR41.15419105
44TAOK11.14503755
45LYN1.14424726
46STK41.12142203
47TAOK31.11001420
48MAP2K71.10580752
49TGFBR21.10022532
50SIK31.05401877
51ACVR1B0.97659137
52MARK30.94837806
53DYRK30.94353203
54KSR20.93340800
55CLK10.91611083
56RPS6KA40.89575267
57FES0.88931039
58EIF2AK20.85215928
59TRPM70.84047088
60PRKCQ0.82852381
61BMX0.81821592
62PIK3CG0.80957894
63RIPK10.80934306
64EIF2AK30.80111112
65FGR0.79577337
66IRAK10.77882805
67NME20.75611051
68SGK20.75595792
69LRRK20.67884888
70MAP3K60.67387821
71MAP2K30.64507618
72MAP2K40.63688824
73DYRK1B0.62592946
74NUAK10.60690252
75ABL10.59892977
76MAP4K20.59097232
77CDK190.58813310
78STK30.57736163
79PRKCD0.57416878
80MAP3K50.56343205
81MAPKAPK20.56309637
82CAMKK10.55119370
83YES10.54904102
84CDK120.54820672
85SIK20.54244362
86TAOK20.54243526
87PLK20.53818274
88SRPK10.53554038
89ERBB30.53080092
90EGFR0.52332610
91MATK0.52082325
92SGK30.51218218
93MAPK130.49838714
94WNK30.49269362
95NLK0.48344396
96CDK60.47854063
97MAP3K110.47513135
98GRK70.46729411
99GRK60.46698506
100TESK10.45738923
101ABL20.45325600
102SGK4940.43626004
103SGK2230.43626004
104MAP3K120.43421318
105DYRK20.42582347
106CAMK40.41952128
107MAPK70.39917554
108STK240.39845477
109CSNK1A1L0.39764551
110MOS0.38827938
111RPS6KA50.37420247
112MAP3K100.37297986
113PTK60.37066877
114PKN10.36124805
115ERN10.34938077
116ADRBK20.34176857
117BCR0.31436066
118HIPK20.29867029
119RPS6KA60.29588474
120ARAF0.29328834
121IGF1R0.27460852
122MAP3K10.25278712
123FYN0.24775724
124SCYL20.23743326
125DMPK0.23496042
126IRAK20.23479050
127PDGFRB0.22610978
128RPS6KA10.22378623
129TTN0.20455762
130INSR0.20399394
131RAF10.20380896
132BMPR1B0.19647443
133MAP3K80.18893663

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.70742241
2Allograft rejection_Homo sapiens_hsa053303.59680058
3Leishmaniasis_Homo sapiens_hsa051403.04900920
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.64844632
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.58089561
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.56857224
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.40229913
8Measles_Homo sapiens_hsa051622.36505632
9Type I diabetes mellitus_Homo sapiens_hsa049402.35311981
10Autoimmune thyroid disease_Homo sapiens_hsa053202.25993050
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20089869
12Osteoclast differentiation_Homo sapiens_hsa043802.19436814
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16044216
14Legionellosis_Homo sapiens_hsa051342.05381119
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01419325
16Rheumatoid arthritis_Homo sapiens_hsa053231.95421608
17Malaria_Homo sapiens_hsa051441.94953552
18Pertussis_Homo sapiens_hsa051331.94097491
19Asthma_Homo sapiens_hsa053101.92587135
20Staphylococcus aureus infection_Homo sapiens_hsa051501.89818217
21Tuberculosis_Homo sapiens_hsa051521.85203534
22TNF signaling pathway_Homo sapiens_hsa046681.82439453
23Influenza A_Homo sapiens_hsa051641.74155682
24Primary immunodeficiency_Homo sapiens_hsa053401.72730112
25Toxoplasmosis_Homo sapiens_hsa051451.66326562
26Herpes simplex infection_Homo sapiens_hsa051681.64703903
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57574595
28Antigen processing and presentation_Homo sapiens_hsa046121.57556987
29Viral myocarditis_Homo sapiens_hsa054161.55057780
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.54577205
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53115858
32Hematopoietic cell lineage_Homo sapiens_hsa046401.52761990
33B cell receptor signaling pathway_Homo sapiens_hsa046621.52075334
34Chemokine signaling pathway_Homo sapiens_hsa040621.49907839
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49483910
36Salmonella infection_Homo sapiens_hsa051321.46210351
37Apoptosis_Homo sapiens_hsa042101.42376406
38African trypanosomiasis_Homo sapiens_hsa051431.41469024
39T cell receptor signaling pathway_Homo sapiens_hsa046601.39591570
40Shigellosis_Homo sapiens_hsa051311.35863778
41Phagosome_Homo sapiens_hsa041451.26365671
42Hepatitis B_Homo sapiens_hsa051611.23274067
43Lysosome_Homo sapiens_hsa041421.21671236
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20794558
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01741599
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99917166
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97216915
48Hepatitis C_Homo sapiens_hsa051600.91962229
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.89276468
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87302483
51Chronic myeloid leukemia_Homo sapiens_hsa052200.83213456
52Acute myeloid leukemia_Homo sapiens_hsa052210.82192156
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79290194
54Epstein-Barr virus infection_Homo sapiens_hsa051690.77731712
55Prolactin signaling pathway_Homo sapiens_hsa049170.77185945
56Pancreatic cancer_Homo sapiens_hsa052120.76915470
57Other glycan degradation_Homo sapiens_hsa005110.75867041
58Amoebiasis_Homo sapiens_hsa051460.73718080
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.73472163
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68666355
61Platelet activation_Homo sapiens_hsa046110.65807369
62Viral carcinogenesis_Homo sapiens_hsa052030.63696244
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.63486593
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61016435
65Small cell lung cancer_Homo sapiens_hsa052220.59660498
66Endometrial cancer_Homo sapiens_hsa052130.59187085
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56153923
68HTLV-I infection_Homo sapiens_hsa051660.55953160
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54458374
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52614336
71Regulation of autophagy_Homo sapiens_hsa041400.51140365
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48746691
73Prion diseases_Homo sapiens_hsa050200.47634405
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46950769
75p53 signaling pathway_Homo sapiens_hsa041150.45131151
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43677958
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43090344
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.41179441
79HIF-1 signaling pathway_Homo sapiens_hsa040660.39298355
80mTOR signaling pathway_Homo sapiens_hsa041500.38365510
81MicroRNAs in cancer_Homo sapiens_hsa052060.37795793
82Endocytosis_Homo sapiens_hsa041440.37441097
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.37210564
84VEGF signaling pathway_Homo sapiens_hsa043700.34562136
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34467586
86MAPK signaling pathway_Homo sapiens_hsa040100.34220539
87Choline metabolism in cancer_Homo sapiens_hsa052310.32589457
88ErbB signaling pathway_Homo sapiens_hsa040120.32347161
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.31673944
90Proteoglycans in cancer_Homo sapiens_hsa052050.31206000
91Notch signaling pathway_Homo sapiens_hsa043300.30920787
92FoxO signaling pathway_Homo sapiens_hsa040680.30548462
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29515051
94Rap1 signaling pathway_Homo sapiens_hsa040150.28068562
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26570251
96Collecting duct acid secretion_Homo sapiens_hsa049660.26225407
97Systemic lupus erythematosus_Homo sapiens_hsa053220.25492937
98Non-small cell lung cancer_Homo sapiens_hsa052230.24594422
99Glioma_Homo sapiens_hsa052140.24297314
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24073377
101Renal cell carcinoma_Homo sapiens_hsa052110.23326511
102Colorectal cancer_Homo sapiens_hsa052100.22946078
103Prostate cancer_Homo sapiens_hsa052150.22370084
104Dorso-ventral axis formation_Homo sapiens_hsa043200.21993188
105GnRH signaling pathway_Homo sapiens_hsa049120.21852672
106Adherens junction_Homo sapiens_hsa045200.18258736
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18196672
108Type II diabetes mellitus_Homo sapiens_hsa049300.16414764
109Pathways in cancer_Homo sapiens_hsa052000.15005600
110Inositol phosphate metabolism_Homo sapiens_hsa005620.10303997
111Focal adhesion_Homo sapiens_hsa045100.10055245
112Insulin resistance_Homo sapiens_hsa049310.09841131
113Ras signaling pathway_Homo sapiens_hsa040140.09577492

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