ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.23202233
2	proteasome assembly (GO:0043248)	5.12192760
3	chaperone-mediated protein transport (GO:0072321)	4.99367370
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.43637815
5	protein deneddylation (GO:0000338)	4.03333991
6	ATP synthesis coupled proton transport (GO:0015986)	3.96383712
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.96383712
8	cullin deneddylation (GO:0010388)	3.76144795
9	ribosomal large subunit biogenesis (GO:0042273)	3.62700483
10	DNA deamination (GO:0045006)	3.54300396
11	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.52391305
12	regulation of mitochondrial translation (GO:0070129)	3.37626041
13	protein targeting to mitochondrion (GO:0006626)	3.37570366
14	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.35388662
15	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.29796991
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.28307682
17	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.28060193
18	negative regulation of ligase activity (GO:0051352)	3.28060193
19	respiratory electron transport chain (GO:0022904)	3.23706768
20	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.17203552
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.17172962
22	ribosome assembly (GO:0042255)	3.16315287
23	DNA replication checkpoint (GO:0000076)	3.16075164
24	protein localization to mitochondrion (GO:0070585)	3.15329390
25	ribosomal small subunit biogenesis (GO:0042274)	3.14138381
26	electron transport chain (GO:0022900)	3.11654287
27	establishment of protein localization to mitochondrion (GO:0072655)	3.10822696
28	DNA catabolic process, exonucleolytic (GO:0000738)	3.09760080
29	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.09506264
30	T-helper 1 type immune response (GO:0042088)	3.05913633
31	folic acid transport (GO:0015884)	3.05697941
32	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.02832397
33	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.01862696
34	cotranslational protein targeting to membrane (GO:0006613)	2.99116129
35	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.99115325
36	termination of RNA polymerase III transcription (GO:0006386)	2.99115325
37	protein targeting to ER (GO:0045047)	2.98499571
38	negative regulation of telomerase activity (GO:0051974)	2.97958235
39	platelet dense granule organization (GO:0060155)	2.97358034
40	CENP-A containing nucleosome assembly (GO:0034080)	2.94914261
41	positive regulation of endothelial cell apoptotic process (GO:2000353)	2.93306637
42	regulation of cellular amino acid metabolic process (GO:0006521)	2.93295570
43	translation (GO:0006412)	2.91758123
44	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.90309993
45	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.89647153
46	viral transcription (GO:0019083)	2.87371726
47	purine nucleobase biosynthetic process (GO:0009113)	2.85384040
48	translational termination (GO:0006415)	2.84047350
49	mitotic metaphase plate congression (GO:0007080)	2.83507258
50	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.82354909
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.82354909
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.82354909
53	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.81700537
54	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.81700537
55	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.81542052
56	necroptotic process (GO:0070266)	2.80767805
57	protein localization to endoplasmic reticulum (GO:0070972)	2.80688480
58	folic acid-containing compound biosynthetic process (GO:0009396)	2.79227748
59	regulation of interferon-alpha production (GO:0032647)	2.78397326
60	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.75520888
61	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.74795994
62	positive regulation of ligase activity (GO:0051351)	2.74510009
63	chromatin remodeling at centromere (GO:0031055)	2.73222391
64	pseudouridine synthesis (GO:0001522)	2.71822049
65	pteridine-containing compound biosynthetic process (GO:0042559)	2.71404084
66	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.69882259
67	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.69882259
68	maturation of SSU-rRNA (GO:0030490)	2.68409459
69	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.67023565
70	positive regulation of interferon-alpha production (GO:0032727)	2.65989457
71	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.64188370
72	establishment of viral latency (GO:0019043)	2.62881247
73	T cell apoptotic process (GO:0070231)	2.62665747
74	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.62191329
75	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.61544615
76	rRNA modification (GO:0000154)	2.61513093
77	regulation of ligase activity (GO:0051340)	2.59018767
78	serine family amino acid biosynthetic process (GO:0009070)	2.58976402
79	ribosomal small subunit assembly (GO:0000028)	2.57729670
80	intracellular pH reduction (GO:0051452)	2.57691577
81	intracellular protein transmembrane import (GO:0044743)	2.54730237
82	protein neddylation (GO:0045116)	2.54592369
83	spliceosomal snRNP assembly (GO:0000387)	2.53288514
84	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53006767
85	ribonucleoprotein complex biogenesis (GO:0022613)	2.51330910
86	mitochondrial transport (GO:0006839)	2.50685476
87	establishment of integrated proviral latency (GO:0075713)	2.49990050
88	regulation of mononuclear cell migration (GO:0071675)	2.49898382
89	protein complex biogenesis (GO:0070271)	2.47225930
90	translational initiation (GO:0006413)	2.46622995
91	rRNA processing (GO:0006364)	2.45878926
92	cellular response to arsenic-containing substance (GO:0071243)	2.43318852
93	viral life cycle (GO:0019058)	2.43267659
94	cofactor transport (GO:0051181)	2.43206291
95	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.42165341
96	lymphocyte apoptotic process (GO:0070227)	2.41715197
97	formation of translation preinitiation complex (GO:0001731)	2.41439813
98	negative regulation of protein ubiquitination (GO:0031397)	2.41111066
99	translational elongation (GO:0006414)	2.40393740
100	regulation of interferon-beta biosynthetic process (GO:0045357)	2.39885961

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.47978782
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.14274364
3	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.96061651
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.47255160
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.36760631
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.27236259
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.25037693
8	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.93850593
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.91030441
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.82323802
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.77159776
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.59918614
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.58158923
14	DCP1A_22483619_ChIP-Seq_HELA_Human	2.53679680
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.51139927
16	E2F7_22180533_ChIP-Seq_HELA_Human	2.46527279
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46519189
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.40439363
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.35095948
20	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.34827354
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.32883106
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.31908249
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.30488313
24	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.30324228
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.25744121
26	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.15240978
27	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.14707828
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.09636136
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.02698357
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.02493292
31	ZNF263_19887448_ChIP-Seq_K562_Human	1.99188683
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.95851434
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.88610864
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.86489698
35	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.81269401
36	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.80498158
37	TFEB_21752829_ChIP-Seq_HELA_Human	1.77734822
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.70413639
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69557775
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.66727546
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.63812438
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.61907013
43	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.59567043
44	AR_21909140_ChIP-Seq_LNCAP_Human	1.59214758
45	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.56453858
46	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.52251023
47	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.47904957
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.47516559
49	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.46051131
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.44957815
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43044756
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.39501580
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38403166
54	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.32126848
55	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.31127830
56	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.29119708
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27160016
58	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.26624398
59	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.26184763
60	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.24506605
61	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.23766584
62	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.23182612
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19905126
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19663734
65	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15501510
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.14542227
67	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.13622746
68	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.13577690
69	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.13384245
70	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12667825
71	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.07483896
72	EWS_26573619_Chip-Seq_HEK293_Human	1.06562449
73	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.05859742
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.04571276
75	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.03878410
76	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00934711
77	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.99448390
78	KDM5A_27292631_Chip-Seq_BREAST_Human	0.94591012
79	* PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.93027650
80	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92876615
81	ELF5_23300383_ChIP-Seq_T47D_Human	0.92302423
82	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.91050636
83	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.90405018
84	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.90052597
85	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89634063
86	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.87708114
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.86208524
88	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.84033309
89	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.82576755
90	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.81837098
91	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.80430964
92	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.80190108
93	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.79404888
94	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.79192551
95	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.79084162
96	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.78068864
97	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.77927213
98	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.77927213
99	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.77927213
100	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.76872256

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.37483628
2	MP0003806_abnormal_nucleotide_metabolis	3.21822889
3	MP0003186_abnormal_redox_activity	3.20058370
4	MP0008058_abnormal_DNA_repair	2.77748788
5	MP0003693_abnormal_embryo_hatching	2.71191897
6	MP0002277_abnormal_respiratory_mucosa	2.66726952
7	MP0003941_abnormal_skin_development	2.65657604
8	MP0004957_abnormal_blastocyst_morpholog	2.59156250
9	MP0006082_CNS_inflammation	2.45101439
10	MP0002653_abnormal_ependyma_morphology	2.38955082
11	MP0002148_abnormal_hypersensitivity_rea	2.30176485
12	MP0005171_absent_coat_pigmentation	2.27263833
13	MP0000372_irregular_coat_pigmentation	2.23541549
14	MP0002837_dystrophic_cardiac_calcinosis	2.11303062
15	MP0000343_altered_response_to	2.07376564
16	MP0008932_abnormal_embryonic_tissue	2.07046289
17	MP0003011_delayed_dark_adaptation	1.92106902
18	MP0010094_abnormal_chromosome_stability	1.89730993
19	MP0005058_abnormal_lysosome_morphology	1.88508058
20	MP0002254_reproductive_system_inflammat	1.87057085
21	MP0003111_abnormal_nucleus_morphology	1.85754422
22	MP0002139_abnormal_hepatobiliary_system	1.74567719
23	MP0009785_altered_susceptibility_to	1.74244969
24	MP0003077_abnormal_cell_cycle	1.68498456
25	MP0006036_abnormal_mitochondrial_physio	1.62485372
26	MP0005084_abnormal_gallbladder_morpholo	1.61371454
27	MP0002877_abnormal_melanocyte_morpholog	1.61007713
28	MP0009764_decreased_sensitivity_to	1.60883929
29	MP0002234_abnormal_pharynx_morphology	1.51246175
30	MP0010234_abnormal_vibrissa_follicle	1.50018898
31	MP0008007_abnormal_cellular_replicative	1.49206611
32	MP0002095_abnormal_skin_pigmentation	1.48223126
33	MP0002163_abnormal_gland_morphology	1.44612292
34	MP0003453_abnormal_keratinocyte_physiol	1.43728199
35	MP0001853_heart_inflammation	1.39182698
36	MP0008004_abnormal_stomach_pH	1.38315642
37	MP0002938_white_spotting	1.35321554
38	MP0009840_abnormal_foam_cell	1.34576379
39	MP0001485_abnormal_pinna_reflex	1.32293985
40	MP0005408_hypopigmentation	1.27911468
41	MP0003195_calcinosis	1.27763761
42	MP0003303_peritoneal_inflammation	1.25098528
43	MP0002090_abnormal_vision	1.25042165
44	MP0001873_stomach_inflammation	1.23819009
45	MP0001764_abnormal_homeostasis	1.23769638
46	MP0001835_abnormal_antigen_presentation	1.22118924
47	MP0005379_endocrine/exocrine_gland_phen	1.19280605
48	MP0000685_abnormal_immune_system	1.18849317
49	MP0001529_abnormal_vocalization	1.16953817
50	MP0000490_abnormal_crypts_of	1.15134346
51	MP0010307_abnormal_tumor_latency	1.14661873
52	MP0006054_spinal_hemorrhage	1.14294066
53	MP0008260_abnormal_autophagy	1.13505578
54	MP0002796_impaired_skin_barrier	1.13063662
55	MP0005501_abnormal_skin_physiology	1.12340640
56	MP0004782_abnormal_surfactant_physiolog	1.11076907
57	MP0005671_abnormal_response_to	1.10638276
58	MP0010030_abnormal_orbit_morphology	1.09209499
59	MP0000350_abnormal_cell_proliferation	1.08420613
60	MP0002452_abnormal_antigen_presenting	1.07616030
61	MP0008873_increased_physiological_sensi	1.06046059
62	MP0008469_abnormal_protein_level	1.05775244
63	MP0000358_abnormal_cell_content/	1.05182657
64	MP0003950_abnormal_plasma_membrane	1.02471268
65	MP0001881_abnormal_mammary_gland	0.98996322
66	MP0009333_abnormal_splenocyte_physiolog	0.98293879
67	MP0002138_abnormal_hepatobiliary_system	0.97967673
68	MP0008875_abnormal_xenobiotic_pharmacok	0.97844791
69	MP0003221_abnormal_cardiomyocyte_apopto	0.95908133
70	MP0001845_abnormal_inflammatory_respons	0.95364331
71	MP0002332_abnormal_exercise_endurance	0.92960467
72	MP0002295_abnormal_pulmonary_circulatio	0.90912763
73	MP0001790_abnormal_immune_system	0.90224536
74	MP0005387_immune_system_phenotype	0.90224536
75	MP0005000_abnormal_immune_tolerance	0.89201831
76	MP0002419_abnormal_innate_immunity	0.89148580
77	MP0001727_abnormal_embryo_implantation	0.89040556
78	MP0001800_abnormal_humoral_immune	0.88959777
79	MP0005174_abnormal_tail_pigmentation	0.88626947
80	MP0005025_abnormal_response_to	0.88310295
81	MP0009763_increased_sensitivity_to	0.87489862
82	MP0008057_abnormal_DNA_replication	0.85540136
83	MP0010352_gastrointestinal_tract_polyps	0.85443542
84	MP0003786_premature_aging	0.84772525
85	MP0000627_abnormal_mammary_gland	0.83900946
86	MP0005319_abnormal_enzyme/_coenzyme	0.83128723
87	MP0005310_abnormal_salivary_gland	0.82693872
88	MP0003448_altered_tumor_morphology	0.81590846
89	MP0002723_abnormal_immune_serum	0.81170284
90	MP0000313_abnormal_cell_death	0.79215275
91	MP0004510_myositis	0.79187716
92	MP0002177_abnormal_outer_ear	0.77135672
93	MP0005332_abnormal_amino_acid	0.77048954
94	MP0003300_gastrointestinal_ulcer	0.76843724
95	MP0005166_decreased_susceptibility_to	0.76148608
96	MP0003075_altered_response_to	0.76115197
97	MP0001177_atelectasis	0.74848089
98	MP0010386_abnormal_urinary_bladder	0.72251739
99	MP0005623_abnormal_meninges_morphology	0.71966938
100	MP0001851_eye_inflammation	0.71429283

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgM level (HP:0003496)	5.07891179
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	5.01594133
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	5.01594133
4	Autoimmune thrombocytopenia (HP:0001973)	4.62086175
5	Increased hepatocellular lipid droplets (HP:0006565)	4.48045410
6	Renal Fanconi syndrome (HP:0001994)	4.13675710
7	Lipid accumulation in hepatocytes (HP:0006561)	4.09633133
8	Autoimmune hemolytic anemia (HP:0001890)	4.02549098
9	Birth length less than 3rd percentile (HP:0003561)	3.88598390
10	Acute necrotizing encephalopathy (HP:0006965)	3.80722870
11	Mitochondrial inheritance (HP:0001427)	3.61923242
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.51960224
13	Increased CSF lactate (HP:0002490)	3.51160750
14	Increased intramyocellular lipid droplets (HP:0012240)	3.49653116
15	Acute encephalopathy (HP:0006846)	3.30285123
16	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.26275079
17	Abnormality of liposaccharide metabolism (HP:0010968)	3.22303035
18	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.22303035
19	Abnormality of glycolipid metabolism (HP:0010969)	3.22303035
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.21996419
21	Progressive macrocephaly (HP:0004481)	3.19950142
22	Respiratory difficulties (HP:0002880)	3.16084429
23	Vacuolated lymphocytes (HP:0001922)	3.15194517
24	Exertional dyspnea (HP:0002875)	3.14246448
25	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.94093026
26	Increased muscle lipid content (HP:0009058)	2.89273085
27	Abnormality of renal resorption (HP:0011038)	2.84005326
28	Cerebral edema (HP:0002181)	2.82469647
29	3-Methylglutaconic aciduria (HP:0003535)	2.75091590
30	Respiratory failure (HP:0002878)	2.71969696
31	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.67496435
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.64305394
33	Abnormality of T cell physiology (HP:0011840)	2.62813741
34	Multiple enchondromatosis (HP:0005701)	2.61347271
35	Nausea (HP:0002018)	2.60789663
36	Lactic acidosis (HP:0003128)	2.57643848
37	Lip pit (HP:0100267)	2.57080377
38	Hepatocellular necrosis (HP:0001404)	2.56133960
39	Congenital ichthyosiform erythroderma (HP:0007431)	2.54025825
40	Patchy hypopigmentation of hair (HP:0011365)	2.50257949
41	Increased serum lactate (HP:0002151)	2.49732134
42	Hepatic necrosis (HP:0002605)	2.48838864
43	Oral leukoplakia (HP:0002745)	2.43444360
44	Macrocytic anemia (HP:0001972)	2.42577408
45	Type I transferrin isoform profile (HP:0003642)	2.41316236
46	Parakeratosis (HP:0001036)	2.30482096
47	Increased serum pyruvate (HP:0003542)	2.28601747
48	Cutaneous melanoma (HP:0012056)	2.26960066
49	Abnormality of the anterior horn cell (HP:0006802)	2.24766611
50	Degeneration of anterior horn cells (HP:0002398)	2.24766611
51	Exercise intolerance (HP:0003546)	2.21526044
52	Reduced antithrombin III activity (HP:0001976)	2.20744087
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.19014782
54	Abnormality of alanine metabolism (HP:0010916)	2.19014782
55	Hyperalaninemia (HP:0003348)	2.19014782
56	Neutropenia (HP:0001875)	2.15824185
57	Poor head control (HP:0002421)	2.15476464
58	Abnormality of serum amino acid levels (HP:0003112)	2.09230390
59	Lethargy (HP:0001254)	2.08416483
60	Sparse eyelashes (HP:0000653)	2.08263798
61	Eosinophilia (HP:0001880)	2.08103766
62	Symptomatic seizures (HP:0011145)	2.04412229
63	Steatorrhea (HP:0002570)	2.03821570
64	Posterior subcapsular cataract (HP:0007787)	2.02808451
65	Abnormality of urine glucose concentration (HP:0011016)	2.01995794
66	Glycosuria (HP:0003076)	2.01995794
67	Abnormality of methionine metabolism (HP:0010901)	2.00645312
68	Abnormal glycosylation (HP:0012345)	2.00555901
69	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00555901
70	Abnormal protein N-linked glycosylation (HP:0012347)	2.00555901
71	Abnormal protein glycosylation (HP:0012346)	2.00555901
72	Methylmalonic acidemia (HP:0002912)	1.99122247
73	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98970902
74	Abnormality of glycolysis (HP:0004366)	1.98020646
75	Reticulocytopenia (HP:0001896)	1.94785380
76	X-linked dominant inheritance (HP:0001423)	1.94664018
77	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94336395
78	Hypergammaglobulinemia (HP:0010702)	1.91896765
79	Megaloblastic anemia (HP:0001889)	1.91223144
80	Hyperglycinemia (HP:0002154)	1.91001868
81	Basal ganglia calcification (HP:0002135)	1.90719266
82	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.90598072
83	Leukodystrophy (HP:0002415)	1.90156258
84	Methylmalonic aciduria (HP:0012120)	1.88144965
85	Axonal loss (HP:0003447)	1.87261856
86	Aplastic anemia (HP:0001915)	1.85688749
87	Albinism (HP:0001022)	1.84297877
88	Abnormal number of erythroid precursors (HP:0012131)	1.82633834
89	Abnormality of macrophages (HP:0004311)	1.81770649
90	Abnormality of T cell number (HP:0011839)	1.80632341
91	CNS demyelination (HP:0007305)	1.80000414
92	Hyperphosphaturia (HP:0003109)	1.79558761
93	Ectropion (HP:0000656)	1.78967643
94	Stenosis of the external auditory canal (HP:0000402)	1.78266969
95	Abnormality of the basal ganglia (HP:0002134)	1.77938647
96	Nuclear cataract (HP:0100018)	1.73820566
97	Hypoplasia of the uterus (HP:0000013)	1.73780747
98	Neoplasm of head and neck (HP:0012288)	1.72772161
99	Esophageal neoplasm (HP:0100751)	1.72772161
100	Microvesicular hepatic steatosis (HP:0001414)	1.72756002

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.67016204
2	BUB1	3.45563786
3	PDK2	3.44077037
4	PBK	3.40432150
5	MST4	3.17169875
6	NME2	2.96939054
7	STK16	2.56269825
8	EIF2AK3	2.46378033
9	NEK1	2.31123313
10	PIK3CA	2.27807640
11	WEE1	2.11066455
12	VRK1	1.95587317
13	STK24	1.94453288
14	VRK2	1.93611118
15	MOS	1.93518368
16	PIM2	1.88849036
17	ARAF	1.83313731
18	STK38L	1.69197030
19	TRIM28	1.66372898
20	BMPR2	1.63211778
21	ZAK	1.60208253
22	MAP3K12	1.59585322
23	GRK7	1.57856805
24	PNCK	1.52642258
25	WNK3	1.51860166
26	TAF1	1.46474929
27	EIF2AK1	1.42111211
28	TSSK6	1.40210047
29	ACVR1B	1.39637737
30	SRPK1	1.37942660
31	TTK	1.31938057
32	PLK3	1.29424138
33	STK10	1.23839822
34	TNIK	1.23579167
35	IRAK3	1.22715184
36	BCKDK	1.12707680
37	TESK1	1.10793252
38	BCR	1.10542661
39	MAPK15	1.04067524
40	TGFBR2	1.03685577
41	STK3	1.03093074
42	BRSK2	0.95270621
43	LIMK1	0.89793889
44	IKBKB	0.89399024
45	PLK1	0.87814211
46	CSNK1G3	0.85933535
47	ABL2	0.85455112
48	NEK9	0.82652795
49	OXSR1	0.82401836
50	BMPR1B	0.79396617
51	MKNK1	0.77954502
52	CSNK1G1	0.77746572
53	MAP3K9	0.76952432
54	EIF2AK2	0.76580207
55	CDC7	0.75762493
56	CSNK1G2	0.75352650
57	TAOK2	0.75014188
58	CDK19	0.74860159
59	STK4	0.74254848
60	LATS2	0.70079307
61	PLK4	0.68167383
62	NEK2	0.66048869
63	NUAK1	0.65721078
64	GRK5	0.64407052
65	TBK1	0.64383929
66	TYK2	0.62304915
67	IKBKE	0.60477061
68	RPS6KA5	0.60127807
69	PAK4	0.59946520
70	PIM1	0.59089415
71	CSNK1A1L	0.57950554
72	BRAF	0.55755873
73	ADRBK2	0.54266350
74	DDR2	0.53750467
75	MAPKAPK5	0.52259276
76	MAP4K2	0.52046473
77	CSNK2A1	0.51223723
78	DAPK3	0.47809500
79	CSNK2A2	0.47062200
80	ERBB4	0.45600983
81	AURKA	0.43878119
82	ERBB3	0.42451188
83	AURKB	0.42202722
84	FGR	0.41892486
85	KIT	0.41732183
86	DYRK3	0.41730205
87	MAP3K5	0.38500802
88	MARK3	0.37248767
89	CCNB1	0.37240690
90	IRAK4	0.36222890
91	SIK3	0.34180091
92	PAK1	0.33866978
93	TESK2	0.33279399
94	CDK3	0.33054042
95	LRRK2	0.32695172
96	CHEK2	0.30381474
97	BRSK1	0.28116965
98	FRK	0.26881597
99	ILK	0.24393048
100	MAP3K14	0.23877756

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.80290031
2	Ribosome_Homo sapiens_hsa03010	3.45278765
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.22834286
4	Protein export_Homo sapiens_hsa03060	2.88701151
5	Parkinsons disease_Homo sapiens_hsa05012	2.62776475
6	Folate biosynthesis_Homo sapiens_hsa00790	2.46125392
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.27069085
8	Mismatch repair_Homo sapiens_hsa03430	2.14920472
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.97724412
10	Caffeine metabolism_Homo sapiens_hsa00232	1.93369165
11	DNA replication_Homo sapiens_hsa03030	1.87239001
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.84607682
13	Homologous recombination_Homo sapiens_hsa03440	1.84169887
14	RNA polymerase_Homo sapiens_hsa03020	1.78831381
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74481787
16	Huntingtons disease_Homo sapiens_hsa05016	1.70186522
17	Allograft rejection_Homo sapiens_hsa05330	1.60764188
18	Sulfur relay system_Homo sapiens_hsa04122	1.55842641
19	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.55366232
20	Alzheimers disease_Homo sapiens_hsa05010	1.52246057
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.50030334
22	Fatty acid elongation_Homo sapiens_hsa00062	1.42904029
23	African trypanosomiasis_Homo sapiens_hsa05143	1.38036681
24	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.36909939
25	Legionellosis_Homo sapiens_hsa05134	1.36746715
26	Sulfur metabolism_Homo sapiens_hsa00920	1.35429194
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.34124611
28	Glutathione metabolism_Homo sapiens_hsa00480	1.29277786
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.27949215
30	Spliceosome_Homo sapiens_hsa03040	1.24309282
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24297850
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.23756818
33	Base excision repair_Homo sapiens_hsa03410	1.22397784
34	Basal transcription factors_Homo sapiens_hsa03022	1.20950811
35	RNA transport_Homo sapiens_hsa03013	1.20704964
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.19792937
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.19067676
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.18178674
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.17542525
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16392527
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12907125
42	One carbon pool by folate_Homo sapiens_hsa00670	1.11881601
43	Pentose phosphate pathway_Homo sapiens_hsa00030	1.10054026
44	Propanoate metabolism_Homo sapiens_hsa00640	1.06067696
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04203538
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03376533
47	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.03083029
48	p53 signaling pathway_Homo sapiens_hsa04115	0.99874366
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.96874148
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96418766
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93174577
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.90753586
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.89755650
54	RNA degradation_Homo sapiens_hsa03018	0.89376143
55	Carbon metabolism_Homo sapiens_hsa01200	0.88929661
56	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.81609774
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.81320949
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81267095
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.80341205
60	Influenza A_Homo sapiens_hsa05164	0.78446455
61	Herpes simplex infection_Homo sapiens_hsa05168	0.76156778
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75033312
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74694554
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.74388323
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.72744382
66	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72545051
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70981713
68	Peroxisome_Homo sapiens_hsa04146	0.70517630
69	Lysosome_Homo sapiens_hsa04142	0.69312950
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68514040
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67334487
72	Cell cycle_Homo sapiens_hsa04110	0.66084258
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64992737
74	* Measles_Homo sapiens_hsa05162	0.63682692
75	Asthma_Homo sapiens_hsa05310	0.61576180
76	Purine metabolism_Homo sapiens_hsa00230	0.59994800
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.58672640
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.57851370
79	Metabolic pathways_Homo sapiens_hsa01100	0.56722616
80	Malaria_Homo sapiens_hsa05144	0.54770314
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53040621
82	Apoptosis_Homo sapiens_hsa04210	0.51306065
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51276673
84	Galactose metabolism_Homo sapiens_hsa00052	0.50439243
85	Sphingolipid metabolism_Homo sapiens_hsa00600	0.49006657
86	Regulation of autophagy_Homo sapiens_hsa04140	0.48506324
87	Antigen processing and presentation_Homo sapiens_hsa04612	0.47073777
88	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.46894766
89	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.46103158
90	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45458802
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43858375
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42722405
93	Nitrogen metabolism_Homo sapiens_hsa00910	0.41935138
94	Mineral absorption_Homo sapiens_hsa04978	0.41275202
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39931674
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.39774624
97	Hepatitis B_Homo sapiens_hsa05161	0.39565824
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.38793037
99	Fatty acid degradation_Homo sapiens_hsa00071	0.38092278
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37701560

RAB9A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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