ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.94532702
2	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.45048426
3	respiratory electron transport chain (GO:0022904)	3.95384291
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.91756039
5	ATP synthesis coupled proton transport (GO:0015986)	3.91741371
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.91741371
7	electron transport chain (GO:0022900)	3.91736161
8	protein neddylation (GO:0045116)	3.88544641
9	signal peptide processing (GO:0006465)	3.51959031
10	extracellular fibril organization (GO:0043206)	3.40483690
11	type B pancreatic cell proliferation (GO:0044342)	3.36779816
12	protein maturation by protein folding (GO:0022417)	3.30038402
13	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.25778175
14	protein retention in ER lumen (GO:0006621)	3.20953993
15	deoxyribonucleotide catabolic process (GO:0009264)	3.13277774
16	positive regulation of TOR signaling (GO:0032008)	3.11209903
17	purine deoxyribonucleotide catabolic process (GO:0009155)	3.09970509
18	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.04062861
19	proteasome assembly (GO:0043248)	3.00833762
20	base-excision repair, AP site formation (GO:0006285)	3.00017006
21	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.99425821
22	ATP hydrolysis coupled proton transport (GO:0015991)	2.99425821
23	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.99305279
24	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.98234363
25	GTP biosynthetic process (GO:0006183)	2.92982423
26	GDP-mannose metabolic process (GO:0019673)	2.92480332
27	hydrogen ion transmembrane transport (GO:1902600)	2.91077066
28	protein targeting to mitochondrion (GO:0006626)	2.90442561
29	protein complex biogenesis (GO:0070271)	2.89376670
30	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.86584382
31	deoxyribose phosphate biosynthetic process (GO:0046385)	2.86584382
32	guanosine-containing compound biosynthetic process (GO:1901070)	2.85217169
33	regulation of mitochondrial translation (GO:0070129)	2.83790721
34	fibril organization (GO:0097435)	2.82821349
35	lipopolysaccharide biosynthetic process (GO:0009103)	2.81090688
36	pyrimidine nucleotide catabolic process (GO:0006244)	2.80815240
37	regulation of cellular amino acid metabolic process (GO:0006521)	2.79853372
38	deoxyribose phosphate catabolic process (GO:0046386)	2.79759371
39	hydrogen peroxide catabolic process (GO:0042744)	2.78471971
40	adhesion of symbiont to host cell (GO:0044650)	2.77667627
41	virion attachment to host cell (GO:0019062)	2.77667627
42	establishment of protein localization to mitochondrion (GO:0072655)	2.77146968
43	nucleoside diphosphate catabolic process (GO:0009134)	2.76097135
44	Golgi transport vesicle coating (GO:0048200)	2.74534709
45	COPI coating of Golgi vesicle (GO:0048205)	2.74534709
46	response to interferon-beta (GO:0035456)	2.69972560
47	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.69821830
48	regulation of oxidative phosphorylation (GO:0002082)	2.66392111
49	NADH metabolic process (GO:0006734)	2.65267165
50	inner mitochondrial membrane organization (GO:0007007)	2.64156910
51	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.63739555
52	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.63189607
53	viral protein processing (GO:0019082)	2.63115043
54	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.62754668
55	mannosylation (GO:0097502)	2.62683291
56	2-deoxyribonucleotide metabolic process (GO:0009394)	2.61737355
57	neurofilament cytoskeleton organization (GO:0060052)	2.61412374
58	protein heterotrimerization (GO:0070208)	2.61143689
59	purine deoxyribonucleotide metabolic process (GO:0009151)	2.60910788
60	nucleotide salvage (GO:0043173)	2.60227354
61	cotranslational protein targeting to membrane (GO:0006613)	2.59426470
62	negative regulation of JAK-STAT cascade (GO:0046426)	2.59106402
63	mitotic nuclear envelope reassembly (GO:0007084)	2.58458591
64	nuclear envelope reassembly (GO:0031468)	2.58458591
65	proton transport (GO:0015992)	2.58338798
66	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.58139309
67	protein targeting to ER (GO:0045047)	2.57256595
68	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.56539452
69	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.55062939
70	protein localization to endoplasmic reticulum (GO:0070972)	2.54879964
71	hydrogen transport (GO:0006818)	2.54812466
72	protein deneddylation (GO:0000338)	2.54623539
73	positive regulation of actin filament depolymerization (GO:0030836)	2.53825043
74	regulation of metalloenzyme activity (GO:0048552)	2.53273751
75	galactose catabolic process (GO:0019388)	2.53175655
76	ATP biosynthetic process (GO:0006754)	2.52418857
77	neuromuscular process controlling posture (GO:0050884)	2.51971226
78	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50320160
79	transferrin transport (GO:0033572)	2.49581447
80	creatine metabolic process (GO:0006600)	2.49185604
81	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.47241107
82	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.47241107
83	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.46292164
84	cullin deneddylation (GO:0010388)	2.45864280
85	chaperone-mediated protein transport (GO:0072321)	2.45004381
86	lipopolysaccharide metabolic process (GO:0008653)	2.43840215
87	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.42428502
88	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.42428502
89	NADH dehydrogenase complex assembly (GO:0010257)	2.42428502
90	deoxyribose phosphate metabolic process (GO:0019692)	2.42253269
91	protein localization to mitochondrion (GO:0070585)	2.41531895
92	oxidative phosphorylation (GO:0006119)	2.41450475
93	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.40045612
94	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.40045612
95	regulation of integrin-mediated signaling pathway (GO:2001044)	2.39852384
96	virion assembly (GO:0019068)	2.39833160
97	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.38852286
98	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.38816622
99	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.37098896
100	sequestering of actin monomers (GO:0042989)	2.36792482
101	protein insertion into membrane (GO:0051205)	2.36338441
102	oxaloacetate metabolic process (GO:0006107)	2.35875590
103	cellular response to zinc ion (GO:0071294)	2.35507287
104	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.35322173
105	neuronal action potential propagation (GO:0019227)	2.35196805
106	UTP biosynthetic process (GO:0006228)	2.34779975
107	lipoxygenase pathway (GO:0019372)	2.33867466
108	purine nucleotide salvage (GO:0032261)	2.32522111
109	hydrogen peroxide metabolic process (GO:0042743)	2.32415785
110	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.32175686
111	pyrimidine nucleoside salvage (GO:0043097)	2.32165641
112	pyrimidine-containing compound salvage (GO:0008655)	2.32165641
113	trivalent inorganic cation transport (GO:0072512)	2.29374381
114	ferric iron transport (GO:0015682)	2.29374381
115	detection of temperature stimulus (GO:0016048)	2.28480371
116	ribosomal small subunit assembly (GO:0000028)	2.27761043
117	mitochondrion degradation (GO:0000422)	2.27290517
118	respiratory chain complex IV assembly (GO:0008535)	2.26929525
119	negative regulation of cation channel activity (GO:2001258)	2.26808422
120	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.26381625
121	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.26081838
122	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.26081838
123	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.26071717
124	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.25906172
125	regulation of autophagic vacuole assembly (GO:2000785)	2.25470464
126	negative regulation of erythrocyte differentiation (GO:0045647)	2.24758755
127	viral transcription (GO:0019083)	2.23573685
128	cellular response to nicotine (GO:0071316)	2.23312337
129	positive regulation of mitochondrial fission (GO:0090141)	2.23078092
130	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.22906993
131	cytochrome complex assembly (GO:0017004)	2.22763115
132	succinate metabolic process (GO:0006105)	2.19840471
133	detection of calcium ion (GO:0005513)	2.18847835
134	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.18654648
135	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.18174382
136	metallo-sulfur cluster assembly (GO:0031163)	2.17843321
137	iron-sulfur cluster assembly (GO:0016226)	2.17843321
138	synaptic vesicle exocytosis (GO:0016079)	2.16728153
139	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.11669265
140	autophagic vacuole fusion (GO:0000046)	2.10587815
141	glutathione biosynthetic process (GO:0006750)	2.09189297
142	platelet dense granule organization (GO:0060155)	2.09171550
143	antigen processing and presentation via MHC class Ib (GO:0002475)	2.07481819
144	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.07096417
145	translational termination (GO:0006415)	2.06883838
146	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.06745054
147	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.06155558
148	neuronal action potential (GO:0019228)	2.06129509
149	protein targeting to membrane (GO:0006612)	2.05856015
150	ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)	2.04312840
151	cellular response to glucagon stimulus (GO:0071377)	2.03510871
152	phagosome maturation (GO:0090382)	2.02487762
153	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.01294495
154	glycoside metabolic process (GO:0016137)	1.99231309
155	ribonucleoside diphosphate metabolic process (GO:0009185)	1.99033089
156	cellular copper ion homeostasis (GO:0006878)	1.98646563
157	nonribosomal peptide biosynthetic process (GO:0019184)	1.97714021
158	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	1.97036399
159	activation of protein kinase A activity (GO:0034199)	1.96530703
160	amyloid precursor protein catabolic process (GO:0042987)	1.95796154
161	purine nucleoside diphosphate metabolic process (GO:0009135)	1.95574125
162	purine ribonucleoside diphosphate metabolic process (GO:0009179)	1.95574125

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.78323818
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.42759959
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.37087418
4	* ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.35441734
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.33674954
6	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.26214794
7	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.14622048
8	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.97304237
9	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.92652466
10	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.90270019
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.86161966
12	* LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.84262791
13	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.84156872
14	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.81763188
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.80445727
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.80136597
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.69199849
18	ZNF263_19887448_ChIP-Seq_K562_Human	1.64511292
19	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.64254396
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63144021
21	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.61530728
22	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.60291303
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59656918
24	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.56990651
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52438030
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.51521357
27	LXR_22292898_ChIP-Seq_THP-1_Human	1.51488814
28	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.50669476
29	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50439249
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42729985
31	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.42418619
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.41647113
33	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.41533249
34	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.38855762
35	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.36358358
36	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.34422035
37	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34383591
38	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.34284756
39	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.33335255
40	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.31711089
41	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.30541989
42	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29561481
43	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.29159070
44	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.29148380
45	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.28190001
46	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.26846095
47	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.25240964
48	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.23179148
49	GATA1_22025678_ChIP-Seq_K562_Human	1.20705290
50	CTCF_20526341_ChIP-Seq_ESCs_Human	1.20277820
51	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.20033849
52	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.17733828
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.17717979
54	* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.17178270
55	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.16482627
56	* GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.16403236
57	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.15516473
58	CTCF_27219007_Chip-Seq_Bcells_Human	1.14921645
59	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.14791427
60	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14704225
61	BCL6_27268052_Chip-Seq_Bcells_Human	1.14520637
62	BCOR_27268052_Chip-Seq_Bcells_Human	1.14472178
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14418792
64	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.13991229
65	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13497740
66	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.13103405
67	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12817000
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.12746551
69	VDR_21846776_ChIP-Seq_THP-1_Human	1.12561137
70	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.11486216
71	EZH2_22144423_ChIP-Seq_EOC_Human	1.11478042
72	* SA1_27219007_Chip-Seq_Bcells_Human	1.11167145
73	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.11115550
74	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.10957897
75	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.10683469
76	* EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10163928
77	E2F1_20622854_ChIP-Seq_HELA_Human	1.10147091
78	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10095324
79	* RARB_24833708_ChIP-Seq_LIVER_Mouse	1.07639581
80	* REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07339747
81	PHF8_20622854_ChIP-Seq_HELA_Human	1.06416887
82	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.05771480
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.05702943
84	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05247426
85	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.05207595
86	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.04196210
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.04044623
88	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.03472374
89	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.03472374
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03400355
91	P68_20966046_ChIP-Seq_HELA_Human	1.03308582
92	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03193045
93	* SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.02882723
94	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.02624409
95	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01812312
96	XRN2_22483619_ChIP-Seq_HELA_Human	1.01034487
97	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.00694456
98	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.00362024
99	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00016139
100	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.99436081
101	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.98679274
102	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.98472812
103	DCP1A_22483619_ChIP-Seq_HELA_Human	0.98026375
104	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.96791594
105	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96760029
106	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.96673730
107	RACK7_27058665_Chip-Seq_MCF-7_Human	0.96295925
108	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95956332
109	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.95751772
110	* CTCF_21964334_Chip-Seq_Bcells_Human	0.95470502
111	* CTCF_26484167_Chip-Seq_Bcells_Mouse	0.95021012
112	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.94389541
113	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.92911587
114	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.92722970
115	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.92084686
116	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.91291098
117	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90840886
118	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.89099265
119	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.89094661
120	STAT1_20625510_ChIP-Seq_HELA_Human	0.88954035
121	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.88265491
122	TP63_22573176_ChIP-Seq_HFKS_Human	0.87643326
123	* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.87117002
124	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.86281661
125	* SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.85211868
126	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.84351957
127	* SOX2_20726797_ChIP-Seq_SW620_Human	0.83849047
128	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.83126395
129	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.82436142
130	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.82331419
131	* OCT4_20526341_ChIP-Seq_ESCs_Human	0.82120043
132	NANOG_20526341_ChIP-Seq_ESCs_Human	0.81304959
133	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.80822906
134	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.80657523
135	* REST_21632747_ChIP-Seq_MESCs_Mouse	0.80479184
136	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.79972673
137	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.79716469
138	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.79439166
139	* SMC4_20622854_ChIP-Seq_HELA_Human	0.78712572
140	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.78492948
141	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.78448517
142	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.78324141

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	4.61490969
2	MP0006054_spinal_hemorrhage	2.87335574
3	MP0002837_dystrophic_cardiac_calcinosis	2.83900798
4	MP0005503_abnormal_tendon_morphology	2.47631193
5	MP0005058_abnormal_lysosome_morphology	2.42796307
6	MP0002735_abnormal_chemical_nociception	2.28459803
7	MP0001968_abnormal_touch/_nociception	2.27699877
8	MP0003191_abnormal_cellular_cholesterol	2.22039167
9	MP0002909_abnormal_adrenal_gland	2.20185704
10	MP0010030_abnormal_orbit_morphology	2.19739709
11	MP0000013_abnormal_adipose_tissue	2.18794116
12	MP0002736_abnormal_nociception_after	2.14124584
13	MP0010386_abnormal_urinary_bladder	2.13264388
14	MP0001986_abnormal_taste_sensitivity	2.09403158
15	MP0003806_abnormal_nucleotide_metabolis	2.09154463
16	MP0003011_delayed_dark_adaptation	1.96737536
17	MP0004858_abnormal_nervous_system	1.94923514
18	MP0002653_abnormal_ependyma_morphology	1.94809081
19	MP0005464_abnormal_platelet_physiology	1.93072406
20	MP0002733_abnormal_thermal_nociception	1.92070674
21	MP0001970_abnormal_pain_threshold	1.91523235
22	MP0005083_abnormal_biliary_tract	1.89945300
23	MP0000751_myopathy	1.89022135
24	MP0000749_muscle_degeneration	1.83529866
25	MP0004270_analgesia	1.81814287
26	MP0005257_abnormal_intraocular_pressure	1.76470288
27	MP0006036_abnormal_mitochondrial_physio	1.75792417
28	MP0004272_abnormal_basement_membrane	1.75779699
29	MP0006276_abnormal_autonomic_nervous	1.73314373
30	MP0004036_abnormal_muscle_relaxation	1.70761494
31	MP0003329_amyloid_beta_deposits	1.70694036
32	MP0001905_abnormal_dopamine_level	1.67100146
33	MP0002734_abnormal_mechanical_nocicepti	1.66863297
34	MP0004043_abnormal_pH_regulation	1.62059121
35	MP0002272_abnormal_nervous_system	1.55905563
36	MP0005275_abnormal_skin_tensile	1.54686225
37	MP0001984_abnormal_olfaction	1.53655642
38	MP0009379_abnormal_foot_pigmentation	1.50922479
39	MP0004859_abnormal_synaptic_plasticity	1.50674066
40	MP0005084_abnormal_gallbladder_morpholo	1.45020601
41	MP0002254_reproductive_system_inflammat	1.43575790
42	MP0002822_catalepsy	1.41662565
43	MP0003635_abnormal_synaptic_transmissio	1.38410088
44	MP0005508_abnormal_skeleton_morphology	1.36767127
45	MP0002064_seizures	1.34724668
46	MP0003646_muscle_fatigue	1.33092473
47	MP0003724_increased_susceptibility_to	1.31718616
48	MP0001765_abnormal_ion_homeostasis	1.30555103
49	MP0009840_abnormal_foam_cell	1.29861882
50	MP0005535_abnormal_body_temperature	1.29172790
51	MP0001664_abnormal_digestion	1.27954044
52	MP0005390_skeleton_phenotype	1.26095484
53	MP0002693_abnormal_pancreas_physiology	1.25951164
54	MP0009745_abnormal_behavioral_response	1.25313706
55	MP0003880_abnormal_central_pattern	1.23490352
56	MP0004145_abnormal_muscle_electrophysio	1.22922631
57	MP0003195_calcinosis	1.21889817
58	MP0006082_CNS_inflammation	1.20760706
59	MP0001501_abnormal_sleep_pattern	1.20439090
60	MP0000747_muscle_weakness	1.20369135
61	MP0004142_abnormal_muscle_tone	1.19514285
62	MP0005165_increased_susceptibility_to	1.18877820
63	MP0001756_abnormal_urination	1.18734624
64	MP0001533_abnormal_skeleton_physiology	1.17558725
65	MP0001348_abnormal_lacrimal_gland	1.16329784
66	MP0004147_increased_porphyrin_level	1.16282541
67	MP0003656_abnormal_erythrocyte_physiolo	1.14022409
68	MP0000230_abnormal_systemic_arterial	1.13190989
69	MP0004510_myositis	1.11851835
70	MP0005636_abnormal_mineral_homeostasis	1.11587617
71	MP0001243_abnormal_dermal_layer	1.10588250
72	MP0000920_abnormal_myelination	1.10148616
73	MP0005623_abnormal_meninges_morphology	1.08859026
74	MP0003186_abnormal_redox_activity	1.08676632
75	MP0003866_abnormal_defecation	1.07784481
76	MP0000343_altered_response_to	1.07043211
77	MP0009643_abnormal_urine_homeostasis	1.05996813
78	MP0009384_cardiac_valve_regurgitation	1.04965274
79	MP0002638_abnormal_pupillary_reflex	1.04565819
80	MP0004084_abnormal_cardiac_muscle	1.03133089
81	MP0009764_decreased_sensitivity_to	1.02569058
82	MP0001542_abnormal_bone_strength	1.01838329
83	MP0003279_aneurysm	1.01704513
84	MP0009046_muscle_twitch	1.01431173
85	MP0000015_abnormal_ear_pigmentation	1.00391645
86	MP0002295_abnormal_pulmonary_circulatio	0.99989035
87	MP0000604_amyloidosis	0.99408107
88	MP0005166_decreased_susceptibility_to	0.98631201
89	MP0003436_decreased_susceptibility_to	0.96938193
90	MP0001958_emphysema	0.96604353
91	MP0000681_abnormal_thyroid_gland	0.96494890
92	MP0003075_altered_response_to	0.96402305
93	MP0005167_abnormal_blood-brain_barrier	0.96312552
94	MP0006035_abnormal_mitochondrial_morpho	0.94908462
95	MP0002067_abnormal_sensory_capabilities	0.94572027
96	MP0003879_abnormal_hair_cell	0.94564803
97	MP0005646_abnormal_pituitary_gland	0.94496227
98	MP0000372_irregular_coat_pigmentation	0.94031467
99	MP0005310_abnormal_salivary_gland	0.93903296
100	MP0003633_abnormal_nervous_system	0.93665772
101	MP0003183_abnormal_peptide_metabolism	0.93543897
102	MP0001529_abnormal_vocalization	0.92617363
103	MP0005330_cardiomyopathy	0.92194547
104	MP0009333_abnormal_splenocyte_physiolog	0.91358373
105	MP0003638_abnormal_response/metabolism_	0.90101426
106	MP0003172_abnormal_lysosome_physiology	0.89854234
107	MP0001502_abnormal_circadian_rhythm	0.89552780
108	MP0009785_altered_susceptibility_to	0.88848693
109	MP0004130_abnormal_muscle_cell	0.88314735
110	MP0005670_abnormal_white_adipose	0.88078396
111	MP0005584_abnormal_enzyme/coenzyme_acti	0.87768772
112	MP0000358_abnormal_cell_content/	0.87510319
113	MP0005645_abnormal_hypothalamus_physiol	0.87329250
114	MP0005595_abnormal_vascular_smooth	0.87272524
115	MP0008569_lethality_at_weaning	0.86795609
116	MP0005220_abnormal_exocrine_pancreas	0.85889106
117	MP0001944_abnormal_pancreas_morphology	0.85156627
118	MP0009278_abnormal_bone_marrow	0.84661388
119	MP0002572_abnormal_emotion/affect_behav	0.84462430
120	MP0005379_endocrine/exocrine_gland_phen	0.83461328
121	MP0004215_abnormal_myocardial_fiber	0.83202363
122	MP0002876_abnormal_thyroid_physiology	0.82482148
123	MP0002148_abnormal_hypersensitivity_rea	0.82108635
124	MP0008875_abnormal_xenobiotic_pharmacok	0.80875812
125	MP0005023_abnormal_wound_healing	0.80617889
126	MP0002184_abnormal_innervation	0.80523162
127	MP0008874_decreased_physiological_sensi	0.79658397
128	MP0000003_abnormal_adipose_tissue	0.79570636
129	MP0000538_abnormal_urinary_bladder	0.79456568
130	MP0000750_abnormal_muscle_regeneration	0.79435597
131	MP0001270_distended_abdomen	0.79057038
132	MP0002078_abnormal_glucose_homeostasis	0.78973674
133	MP0001666_abnormal_nutrient_absorption	0.78762604
134	MP0003303_peritoneal_inflammation	0.78194768
135	MP0008260_abnormal_autophagy	0.77908202
136	MP0002163_abnormal_gland_morphology	0.77547522
137	MP0002229_neurodegeneration	0.77453605
138	MP0000858_altered_metastatic_potential	0.73977596
139	MP0005075_abnormal_melanosome_morpholog	0.72951982
140	MP0003786_premature_aging	0.72822127
141	MP0005025_abnormal_response_to	0.72622419
142	MP0002060_abnormal_skin_morphology	0.69693866
143	MP0001764_abnormal_homeostasis	0.69140903
144	MP0009780_abnormal_chondrocyte_physiolo	0.68412377
145	MP0002933_joint_inflammation	0.66468246
146	MP0000639_abnormal_adrenal_gland	0.66257549
147	MP0003795_abnormal_bone_structure	0.65881395
148	MP0008469_abnormal_protein_level	0.64694985
149	MP0008004_abnormal_stomach_pH	0.64435841
150	MP0003283_abnormal_digestive_organ	0.63983711
151	MP0001663_abnormal_digestive_system	0.63607058
152	MP0000767_abnormal_smooth_muscle	0.61439436
153	MP0001845_abnormal_inflammatory_respons	0.60065278
154	MP0000678_abnormal_parathyroid_gland	0.59710991

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature rupture of membranes (HP:0001788)	4.22686273
2	Hepatocellular necrosis (HP:0001404)	4.03656687
3	Acute necrotizing encephalopathy (HP:0006965)	3.97817432
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.91506453
5	Mitochondrial inheritance (HP:0001427)	3.79701764
6	Hepatic necrosis (HP:0002605)	3.76796975
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.62208654
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.62208654
9	Acute encephalopathy (HP:0006846)	3.37009175
10	Myokymia (HP:0002411)	3.36153284
11	Hypothermia (HP:0002045)	3.34438194
12	Prolonged neonatal jaundice (HP:0006579)	3.23059377
13	Progressive macrocephaly (HP:0004481)	3.17341199
14	Neuroendocrine neoplasm (HP:0100634)	3.10701306
15	Petechiae (HP:0000967)	3.07272189
16	Increased CSF lactate (HP:0002490)	3.05547058
17	Pheochromocytoma (HP:0002666)	3.03155032
18	Vacuolated lymphocytes (HP:0001922)	2.93567805
19	Increased muscle lipid content (HP:0009058)	2.91350226
20	Increased intramyocellular lipid droplets (HP:0012240)	2.90054755
21	Vertebral compression fractures (HP:0002953)	2.86791700
22	Retinal dysplasia (HP:0007973)	2.76515842
23	Dysostosis multiplex (HP:0000943)	2.74861385
24	Protrusio acetabuli (HP:0003179)	2.69548008
25	Lactic acidosis (HP:0003128)	2.68632813
26	Respiratory failure (HP:0002878)	2.56433818
27	Myotonia (HP:0002486)	2.49797140
28	Type I transferrin isoform profile (HP:0003642)	2.45699510
29	Palpitations (HP:0001962)	2.44318674
30	Supranuclear gaze palsy (HP:0000605)	2.39496677
31	Microretrognathia (HP:0000308)	2.39438363
32	Progressive neurologic deterioration (HP:0002344)	2.35623248
33	Follicular hyperkeratosis (HP:0007502)	2.34278948
34	Focal dystonia (HP:0004373)	2.34226056
35	Exercise intolerance (HP:0003546)	2.33391809
36	Exertional dyspnea (HP:0002875)	2.28477571
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.28395891
38	Type II lissencephaly (HP:0007260)	2.26352385
39	Craniofacial dystonia (HP:0012179)	2.26279452
40	Hypokinesia (HP:0002375)	2.26153227
41	Abnormality of magnesium homeostasis (HP:0004921)	2.24892920
42	Cerebral edema (HP:0002181)	2.22364426
43	Cerebral hemorrhage (HP:0001342)	2.22241264
44	Renal Fanconi syndrome (HP:0001994)	2.21273607
45	Hand muscle atrophy (HP:0009130)	2.21160713
46	Joint stiffness (HP:0001387)	2.20625575
47	Purpura (HP:0000979)	2.20593983
48	Interstitial pulmonary disease (HP:0006530)	2.18129142
49	Opisthotonus (HP:0002179)	2.17869713
50	Redundant skin (HP:0001582)	2.17788841
51	Asymmetric septal hypertrophy (HP:0001670)	2.17776120
52	Atrophic scars (HP:0001075)	2.17707014
53	Rough bone trabeculation (HP:0100670)	2.15986763
54	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.15766803
55	Increased cerebral lipofuscin (HP:0011813)	2.14710711
56	Dicarboxylic aciduria (HP:0003215)	2.14447169
57	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.14447169
58	Abnormality of dentin (HP:0010299)	2.14324915
59	Upper limb amyotrophy (HP:0009129)	2.13884013
60	Distal upper limb amyotrophy (HP:0007149)	2.13884013
61	Generalized aminoaciduria (HP:0002909)	2.13512394
62	Oligomenorrhea (HP:0000876)	2.11062474
63	Polyphagia (HP:0002591)	2.10498153
64	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.10188374
65	Hypercortisolism (HP:0001578)	2.09233810
66	Visual hallucinations (HP:0002367)	2.08332205
67	Anxiety (HP:0000739)	2.07676837
68	Delayed gross motor development (HP:0002194)	2.07262041
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.04986808
70	Abnormality of glycolipid metabolism (HP:0010969)	2.02838593
71	Abnormality of liposaccharide metabolism (HP:0010968)	2.02838593
72	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.02838593
73	Growth hormone excess (HP:0000845)	2.02667203
74	Testicular atrophy (HP:0000029)	2.02656922
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.01234463
76	Beaking of vertebral bodies (HP:0004568)	2.00716740
77	Limb dystonia (HP:0002451)	1.98731935
78	Emotional lability (HP:0000712)	1.98496683
79	Methylmalonic aciduria (HP:0012120)	1.98071020
80	Progressive muscle weakness (HP:0003323)	1.97296344
81	Increased hepatocellular lipid droplets (HP:0006565)	1.96518909
82	Lipid accumulation in hepatocytes (HP:0006561)	1.96371541
83	Neurofibrillary tangles (HP:0002185)	1.94967617
84	Ankle contracture (HP:0006466)	1.94355410
85	Hyperparathyroidism (HP:0000843)	1.93090216
86	Progressive inability to walk (HP:0002505)	1.92428325
87	Torticollis (HP:0000473)	1.91574560
88	Cervical subluxation (HP:0003308)	1.91376224
89	Systemic lupus erythematosus (HP:0002725)	1.90463203
90	3-Methylglutaconic aciduria (HP:0003535)	1.90295351
91	Stridor (HP:0010307)	1.89495306
92	Poor suck (HP:0002033)	1.88373448
93	Gout (HP:0001997)	1.86390833
94	Abnormal number of erythroid precursors (HP:0012131)	1.85933075
95	Cholecystitis (HP:0001082)	1.83477392
96	Abnormal gallbladder physiology (HP:0012438)	1.83477392
97	Abnormality of fatty-acid metabolism (HP:0004359)	1.83247125
98	Urinary glycosaminoglycan excretion (HP:0003541)	1.83224675
99	Mucopolysacchariduria (HP:0008155)	1.83224675
100	Increased serum lactate (HP:0002151)	1.82906248
101	Abnormality of the vocal cords (HP:0008777)	1.82662036
102	J-shaped sella turcica (HP:0002680)	1.82381315
103	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.81682025
104	Ketoacidosis (HP:0001993)	1.80169058
105	Hepatosplenomegaly (HP:0001433)	1.80132967
106	Muscle stiffness (HP:0003552)	1.80057380
107	Genu recurvatum (HP:0002816)	1.79756616
108	Axonal loss (HP:0003447)	1.79726838
109	Abnormality of the nasal mucosa (HP:0000433)	1.79107772
110	Nuclear cataract (HP:0100018)	1.78583805
111	Optic disc pallor (HP:0000543)	1.78464805
112	Hyperthyroidism (HP:0000836)	1.78008951
113	Myoglobinuria (HP:0002913)	1.77336129
114	Hypomagnesemia (HP:0002917)	1.77079214
115	Fragile skin (HP:0001030)	1.76684245
116	Failure to thrive in infancy (HP:0001531)	1.76283777
117	Neoplasm of the peripheral nervous system (HP:0100007)	1.75518153
118	Slender build (HP:0001533)	1.75435296
119	Nonprogressive disorder (HP:0003680)	1.75387496
120	Spinal rigidity (HP:0003306)	1.73711844
121	Generalized amyotrophy (HP:0003700)	1.73320386
122	Leukodystrophy (HP:0002415)	1.73311850
123	Sudden death (HP:0001699)	1.73154848
124	Adrenal overactivity (HP:0002717)	1.72810151
125	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.72370815
126	Ragged-red muscle fibers (HP:0003200)	1.71929553
127	Calf muscle hypertrophy (HP:0008981)	1.69638531
128	Abnormal pupillary function (HP:0007686)	1.69189971
129	Delusions (HP:0000746)	1.68671570
130	CNS demyelination (HP:0007305)	1.68377441
131	Abnormality of polysaccharide metabolism (HP:0011012)	1.68338494
132	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.68338494
133	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.68338494
134	Loss of speech (HP:0002371)	1.67423127
135	Soft skin (HP:0000977)	1.67025027
136	Nonimmune hydrops fetalis (HP:0001790)	1.66490768
137	Atonic seizures (HP:0010819)	1.65832657
138	Hypokalemic alkalosis (HP:0001949)	1.65418220
139	Abnormality of renal resorption (HP:0011038)	1.64880866
140	Hyperactive renin-angiotensin system (HP:0000841)	1.64851223
141	Exercise-induced myalgia (HP:0003738)	1.64413238
142	Ulnar claw (HP:0001178)	1.64286722
143	Muscle hypertrophy of the lower extremities (HP:0008968)	1.64243734
144	Abnormal protein glycosylation (HP:0012346)	1.63670497
145	Abnormal glycosylation (HP:0012345)	1.63670497
146	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.63670497
147	Abnormal protein N-linked glycosylation (HP:0012347)	1.63670497
148	Elevated erythrocyte sedimentation rate (HP:0003565)	1.63272399
149	Rapidly progressive (HP:0003678)	1.62971066
150	Patent foramen ovale (HP:0001655)	1.62341158
151	Amyloidosis (HP:0011034)	1.61243483
152	Flat capital femoral epiphysis (HP:0003370)	1.61234544
153	Dysautonomia (HP:0002459)	1.59004969
154	Reduced subcutaneous adipose tissue (HP:0003758)	1.58936004

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	3.37684397
2	TESK2	2.91803629
3	VRK2	2.91789344
4	BCKDK	2.83068515
5	MAP3K12	2.78064597
6	NME2	2.74228071
7	ERN1	2.68392335
8	MYLK	2.41538929
9	CAMKK2	2.17706305
10	CDK19	2.07711775
11	MAPKAPK3	2.05590098
12	MUSK	2.04887542
13	NTRK1	1.87462352
14	GRK5	1.85889800
15	PIM2	1.79142377
16	EPHB2	1.68286692
17	PHKG1	1.63180945
18	PHKG2	1.63180945
19	MAPK15	1.58803998
20	PINK1	1.57521640
21	NME1	1.53362960
22	MAPKAPK5	1.52211737
23	KSR2	1.51063709
24	TIE1	1.50753037
25	MAP3K9	1.48041315
26	WNK4	1.40274836
27	MAP3K2	1.37804475
28	MAP3K11	1.36336183
29	STK39	1.34415154
30	LMTK2	1.34387376
31	TAOK2	1.31379306
32	GRK7	1.26690937
33	CSNK1G2	1.25557981
34	MAP2K2	1.24604799
35	MAP3K1	1.24453099
36	CSNK1G1	1.20314284
37	MAP2K3	1.19896490
38	PAK4	1.18789584
39	BRAF	1.14175999
40	OXSR1	1.12622501
41	STK16	1.12017660
42	CSNK1A1L	1.10724867
43	ZAP70	1.10503971
44	LIMK1	1.09192823
45	EPHB1	1.07937726
46	PRKD2	1.07004838
47	PRKD3	1.04163395
48	TRIB3	1.03659437
49	TBK1	1.02369117
50	TNK2	0.95481855
51	DAPK3	0.95300772
52	CAMK2G	0.94414383
53	PAK1	0.93627904
54	MAP3K3	0.93247982
55	DYRK2	0.91792649
56	LRRK2	0.91775099
57	NTRK3	0.89617244
58	MAP2K7	0.85958991
59	ILK	0.85685918
60	DAPK2	0.85115509
61	HIPK2	0.85045212
62	GRK1	0.84632459
63	PTK2	0.83388557
64	PRKCI	0.83016136
65	TGFBR2	0.82921918
66	GRK6	0.82638367
67	MINK1	0.82212575
68	MAP2K1	0.80397437
69	CAMK2D	0.79870709
70	KDR	0.78508807
71	MATK	0.78358905
72	MAP3K13	0.78201591
73	MAP4K2	0.76665279
74	MST4	0.76641424
75	CAMK1	0.75937569
76	BMX	0.75379949
77	TLK1	0.73434717
78	RET	0.72638176
79	ADRBK2	0.71994167
80	PRKG2	0.71443341
81	MAP2K6	0.71278961
82	FER	0.71220659
83	EPHA3	0.70813325
84	MAP2K4	0.70657557
85	PAK6	0.70381723
86	TAOK1	0.70049705
87	SCYL2	0.70015939
88	DDR2	0.69106854
89	CAMKK1	0.67317671
90	IRAK3	0.66432798
91	CAMK2B	0.66020099
92	INSRR	0.65785597
93	AURKA	0.65713621
94	IRAK1	0.65630267
95	TESK1	0.65469338
96	TYK2	0.64880609
97	MAPK12	0.62007280
98	PDPK1	0.60293892
99	RPS6KA5	0.59683616
100	PIK3CG	0.59150754
101	PRKCE	0.58302661
102	ADRBK1	0.58142769
103	EPHA2	0.55359101
104	IKBKB	0.55179858
105	PRKCH	0.54470161
106	FES	0.54365317
107	MAP4K1	0.54054294
108	BMPR1B	0.53324742
109	FLT3	0.52830349
110	RAF1	0.51452067
111	SYK	0.50598492
112	CDK5	0.49496604
113	UHMK1	0.49379043
114	PDK2	0.48824915
115	CSNK1G3	0.48275079
116	CAMK2A	0.47823104
117	SIK3	0.46435747
118	MOS	0.45874410
119	DAPK1	0.45519731
120	RPS6KA2	0.45481610
121	CDK14	0.45180733
122	IRAK2	0.43889382
123	VRK1	0.43841919
124	PRKCG	0.43448502
125	PTK2B	0.42696443
126	SGK494	0.41721875
127	SGK223	0.41721875
128	TTN	0.41310388
129	PRKD1	0.41307651
130	TEC	0.40259854
131	ABL2	0.40051931
132	PDK1	0.39853750
133	PRKCD	0.39503167
134	MAP3K4	0.39485289
135	ROCK1	0.39291253
136	ROCK2	0.38925634
137	BUB1	0.36995004
138	CDK11A	0.34892701
139	DYRK1B	0.34664977
140	PAK3	0.34426681
141	PLK2	0.34114214
142	ZAK	0.33016275
143	KIT	0.32725820
144	PRKCA	0.31624300
145	GSK3A	0.30866551

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.47805314
2	Parkinsons disease_Homo sapiens_hsa05012	3.85788900
3	Protein export_Homo sapiens_hsa03060	3.28279502
4	Alzheimers disease_Homo sapiens_hsa05010	2.94419736
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.58922056
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.47547239
7	Vibrio cholerae infection_Homo sapiens_hsa05110	2.34951045
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.28904830
9	Huntingtons disease_Homo sapiens_hsa05016	2.25541688
10	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.21012705
11	Ribosome_Homo sapiens_hsa03010	2.10164085
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.08584385
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96369217
14	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.69812865
15	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.68580453
16	Lysosome_Homo sapiens_hsa04142	1.57596607
17	Pancreatic secretion_Homo sapiens_hsa04972	1.51452537
18	Other glycan degradation_Homo sapiens_hsa00511	1.50282371
19	Sulfur metabolism_Homo sapiens_hsa00920	1.45528247
20	RNA polymerase_Homo sapiens_hsa03020	1.41357162
21	Fatty acid elongation_Homo sapiens_hsa00062	1.32711569
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32333565
23	Insulin secretion_Homo sapiens_hsa04911	1.28572978
24	Olfactory transduction_Homo sapiens_hsa04740	1.23702243
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.21937497
26	Regulation of autophagy_Homo sapiens_hsa04140	1.20307236
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16535738
28	Proteasome_Homo sapiens_hsa03050	1.13300663
29	Pentose phosphate pathway_Homo sapiens_hsa00030	1.12361343
30	Sulfur relay system_Homo sapiens_hsa04122	1.11756119
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.08659724
32	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.06926640
33	Folate biosynthesis_Homo sapiens_hsa00790	1.05855014
34	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.02449409
35	Taste transduction_Homo sapiens_hsa04742	1.01286894
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00305389
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99328539
38	Base excision repair_Homo sapiens_hsa03410	0.97910783
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.97437994
40	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.96689340
41	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.95961042
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.94966397
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.94527830
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92013350
45	GABAergic synapse_Homo sapiens_hsa04727	0.90917873
46	Circadian entrainment_Homo sapiens_hsa04713	0.90231412
47	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.85256299
48	Gastric acid secretion_Homo sapiens_hsa04971	0.81674397
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81456284
50	Propanoate metabolism_Homo sapiens_hsa00640	0.81224999
51	Serotonergic synapse_Homo sapiens_hsa04726	0.80585151
52	Salivary secretion_Homo sapiens_hsa04970	0.80451813
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.79688576
54	Phagosome_Homo sapiens_hsa04145	0.79567515
55	Cholinergic synapse_Homo sapiens_hsa04725	0.77914377
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.77831142
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.77587888
58	Shigellosis_Homo sapiens_hsa05131	0.76787260
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74669960
60	Cocaine addiction_Homo sapiens_hsa05030	0.74667498
61	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.74592082
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74572373
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.73074092
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69424778
65	Morphine addiction_Homo sapiens_hsa05032	0.68849621
66	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.67858331
67	Purine metabolism_Homo sapiens_hsa00230	0.67481310
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66407470
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64179727
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.61562648
71	Protein digestion and absorption_Homo sapiens_hsa04974	0.60555131
72	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.60464857
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59596502
74	Amphetamine addiction_Homo sapiens_hsa05031	0.59003863
75	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58819426
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57549728
77	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.56712889
78	Renin secretion_Homo sapiens_hsa04924	0.56594054
79	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.54218442
80	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.54072426
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53045105
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.52892726
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52142450
84	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.51690698
85	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.51541194
86	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.51453903
87	Galactose metabolism_Homo sapiens_hsa00052	0.51053647
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51002850
89	Metabolic pathways_Homo sapiens_hsa01100	0.49992788
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.49867294
91	Prion diseases_Homo sapiens_hsa05020	0.49644653
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49638311
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.48195737
94	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.48002569
95	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47678462
96	Mineral absorption_Homo sapiens_hsa04978	0.45892387
97	Long-term potentiation_Homo sapiens_hsa04720	0.45223828
98	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.44892747
99	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44501481
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43748124
101	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43624411
102	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42604342
103	Glutamatergic synapse_Homo sapiens_hsa04724	0.41876062
104	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40720050
105	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40031177
106	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.39056460
107	Malaria_Homo sapiens_hsa05144	0.38043715
108	Endocytosis_Homo sapiens_hsa04144	0.36757580
109	Peroxisome_Homo sapiens_hsa04146	0.34321192
110	GnRH signaling pathway_Homo sapiens_hsa04912	0.34318633
111	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34273698
112	Gap junction_Homo sapiens_hsa04540	0.33878506
113	Allograft rejection_Homo sapiens_hsa05330	0.32424231
114	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32251086
115	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31718550
116	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31406129
117	Phenylalanine metabolism_Homo sapiens_hsa00360	0.31190072
118	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.31038485
119	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.30797526
120	Glutathione metabolism_Homo sapiens_hsa00480	0.30728765
121	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.30377284
122	Histidine metabolism_Homo sapiens_hsa00340	0.29282009
123	VEGF signaling pathway_Homo sapiens_hsa04370	0.29084648
124	Pertussis_Homo sapiens_hsa05133	0.28106228
125	Carbon metabolism_Homo sapiens_hsa01200	0.28086817
126	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26431508
127	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26397811
128	Insulin signaling pathway_Homo sapiens_hsa04910	0.26341358
129	cAMP signaling pathway_Homo sapiens_hsa04024	0.25734495
130	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.25609552
131	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.25601423
132	Salmonella infection_Homo sapiens_hsa05132	0.25593577
133	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.20959491
134	Graft-versus-host disease_Homo sapiens_hsa05332	0.20599699
135	Asthma_Homo sapiens_hsa05310	0.18783483
136	ECM-receptor interaction_Homo sapiens_hsa04512	0.18225886
137	Fat digestion and absorption_Homo sapiens_hsa04975	0.18082232
138	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.16644470
139	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.16514689
140	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.14453674

RABAC1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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